Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity	MTMR7 MTMR8	7.56e-05	11	24	2	GO:0052629
GeneOntologyMolecularFunction	phosphatidylinositol-3-phosphate phosphatase activity	MTMR7 MTMR8	1.25e-04	14	24	2	GO:0004438
GeneOntologyMolecularFunction	phosphatidylinositol monophosphate phosphatase activity	MTMR7 MTMR8	1.44e-04	15	24	2	GO:0052744
GeneOntologyMolecularFunction	phosphatidylinositol-3,5-bisphosphate phosphatase activity	MTMR7 MTMR8	1.64e-04	16	24	2	GO:0106018
GeneOntologyMolecularFunction	phosphatidylinositol bisphosphate phosphatase activity	MTMR7 MTMR8	4.77e-04	27	24	2	GO:0034593
GeneOntologyMolecularFunction	phosphatidylinositol phosphate phosphatase activity	MTMR7 MTMR8	5.90e-04	30	24	2	GO:0052866
Domain	PPASE_MYOTUBULARIN	MTMR7 MTMR8	1.43e-04	14	24	2	PS51339
Domain	Myotubularin-like_Pase_dom	MTMR7 MTMR8	1.43e-04	14	24	2	IPR010569
Domain	Myotubularin_fam	MTMR7 MTMR8	1.43e-04	14	24	2	IPR030564
Domain	Myotub-related	MTMR7 MTMR8	1.43e-04	14	24	2	PF06602
Domain	-	MTMR7 NECAP2 MYO7B MTMR8	1.44e-03	391	24	4	2.30.29.30
Domain	PH_dom-like	MTMR7 NECAP2 MYO7B MTMR8	1.97e-03	426	24	4	IPR011993
Domain	Tyr_Pase_cat	MTMR7 MTMR8	2.59e-03	59	24	2	IPR003595
Domain	PTPc_motif	MTMR7 MTMR8	2.59e-03	59	24	2	SM00404
Domain	Tyr_Pase_AS	MTMR7 MTMR8	3.93e-03	73	24	2	IPR016130
Domain	TYR_PHOSPHATASE_1	MTMR7 MTMR8	5.42e-03	86	24	2	PS00383
Domain	Cys-rich_flank_reg_C	LINGO3 SLITRK1	5.92e-03	90	24	2	IPR000483
Domain	LRRCT	LINGO3 SLITRK1	5.92e-03	90	24	2	SM00082
Domain	LRRNT	LINGO3 SLITRK1	6.98e-03	98	24	2	IPR000372
Domain	LRRNT	LINGO3 SLITRK1	6.98e-03	98	24	2	SM00013
Domain	Prot-tyrosine_phosphatase-like	MTMR7 MTMR8	7.12e-03	99	24	2	IPR029021
Pathway	WP_8P231_COPY_NUMBER_VARIATION_SYNDROME	MTMR7 MEPE MTMR8	3.48e-05	54	17	3	M48073
Pubmed	Activating killer immunoglobulin-like receptor incompatibilities enhance graft-versus-host disease and affect survival after allogeneic hematopoietic stem cell transplantation.	KIR2DS3 KIR2DS5	1.61e-06	3	26	2	19500138
Pubmed	A novel surface molecule homologous to the p58/p50 family of receptors is selectively expressed on a subset of human natural killer cells and induces both triggering of cell functions and proliferation.	KIR2DS3 KIR2DS5	1.61e-06	3	26	2	8765026
Pubmed	The myotubularin family: from genetic disease to phosphoinositide metabolism.	MTMR7 MTMR8	1.61e-06	3	26	2	11275328
Pubmed	Killer-cell immunoglobulin-like receptors and falciparum malaria in southwest Nigeria.	KIR2DS3 KIR2DS5	1.61e-06	3	26	2	24929143
Pubmed	A role for KIR gene variants other than KIR2DS1 in conferring susceptibility to psoriasis.	KIR2DS3 KIR2DS5	3.22e-06	4	26	2	16829306
Pubmed	In contrast to other stimulatory natural killer cell immunoglobulin-like receptor loci, several KIR2DS5 alleles predominate in African Americans.	KIR2DS3 KIR2DS5	5.37e-06	5	26	2	19410616
Pubmed	NullHap--a versatile application to estimate haplotype frequencies from unphased genotypes in the presence of null alleles.	KIR2DS3 KIR2DS5	1.50e-05	8	26	2	18681957
Pubmed	Molecular clones of the p58 NK cell receptor reveal immunoglobulin-related molecules with diversity in both the extra- and intracellular domains.	KIR2DS3 KIR2DS5	1.93e-05	9	26	2	7749980
Pubmed	Alternatively spliced forms of human killer inhibitory receptors.	KIR2DS3 KIR2DS5	1.93e-05	9	26	2	8662091
Pubmed	Assessment of killer cell immunoglobulinlike receptor expression and corresponding HLA class I phenotypes demonstrates heterogenous KIR expression independent of anticipated HLA class I ligands.	KIR2DS3 KIR2DS5	2.41e-05	10	26	2	12559621
Pubmed	Different patterns of evolution in the centromeric and telomeric regions of group A and B haplotypes of the human killer cell Ig-like receptor locus.	KIR2DS3 KIR2DS5	2.41e-05	10	26	2	21206914
Pubmed	Natural killer cells and immune surveillance.	KIR2DS3 KIR2DS5	2.94e-05	11	26	2	18830515
Pubmed	[Genotype analysis of killer cell immunoglobulin-like receptors in Graves' disease patients].	KIR2DS3 KIR2DS5	2.94e-05	11	26	2	19664392
Pubmed	Distribution of killer cell immunoglobulin-like receptors (KIR) and their HLA-C ligands in two Iranian populations.	KIR2DS3 KIR2DS5	3.53e-05	12	26	2	19936734
Pubmed	Association of killer cell immunoglobulin-like receptors with primary Sjogren's syndrome.	KIR2DS3 KIR2DS5	3.53e-05	12	26	2	19181658
Pubmed	Systematic analysis of myotubularins: heteromeric interactions, subcellular localisation and endosome related functions.	MTMR7 MTMR8	3.53e-05	12	26	2	16787938
Pubmed	Association of killer cell immunoglobulin-like receptor 2DL5 with systemic lupus erythematosus and accompanying infections.	KIR2DS3 KIR2DS5	3.53e-05	12	26	2	20371502
Pubmed	[Relationship between CMV reactivation and KIR haplotype/HLA-Cw genotype in patients after unrelated-donor hematopoietic stem cell transplantation.].	KIR2DS3 KIR2DS5	3.53e-05	12	26	2	20137308
Pubmed	[Study on the polymorphism of killer cell immunoglobulin like receptor (KIR) gene with systemic lupus erythematosus of North population in China].	KIR2DS3 KIR2DS5	4.17e-05	13	26	2	18687225
Pubmed	KIR and HLA genotypes are associated with disease progression and survival following autologous hematopoietic stem cell transplantation for high-risk neuroblastoma.	KIR2DS3 KIR2DS5	4.17e-05	13	26	2	19934297
Pubmed	Different KIRs confer susceptibility and protection to adults with latent autoimmune diabetes in Latvian and Asian Indian populations.	KIR2DS3 KIR2DS5	4.17e-05	13	26	2	19120281
Pubmed	Distribution of killer cell immunoglobulin-like receptor genes in the Chinese Han population.	KIR2DS3 KIR2DS5	4.86e-05	14	26	2	15896204
Pubmed	Frequencies of killer immunoglobulin-like receptor genotypes influence susceptibility to spontaneous abortion.	KIR2DS3 KIR2DS5	4.86e-05	14	26	2	19875891
Pubmed	Multiple sclerosis associates with LILRA3 deletion in Spanish patients.	KIR2DS3 KIR2DS5	4.86e-05	14	26	2	19421224
Pubmed	Killer cell immunoglobulin-like receptor gene diversity in a Caucasian population of southern Brazil.	KIR2DS3 KIR2DS5	5.61e-05	15	26	2	20082646
Pubmed	KIR genes polymorphism in Argentinean Caucasoid and Amerindian populations.	KIR2DS3 KIR2DS5	5.61e-05	15	26	2	17498266
Pubmed	Killer cell immunoglobulin-like receptor genotype and killer cell immunoglobulin-like receptor-human leukocyte antigen C ligand compatibility affect the severity of hepatitis C virus recurrence after liver transplantation.	KIR2DS3 KIR2DS5	5.61e-05	15	26	2	19326408
Pubmed	Disparate distribution of activating and inhibitory killer cell immunoglobulin-like receptor genes in patients with systemic lupus erythematosus.	KIR2DS3 KIR2DS5	5.61e-05	15	26	2	19926642
Pubmed	Killer cell immunoglobulin-like receptors in HLA-B27-associated acute anterior uveitis, with and without axial spondyloarthropathy.	KIR2DS3 KIR2DS5	5.61e-05	15	26	2	19850842
Pubmed	Killer immunoglobulin-like receptors (KIR2DL2 and/or KIR2DS2) in presence of their ligand (HLA-C1 group) protect against chronic myeloid leukaemia.	KIR2DS3 KIR2DS5	5.61e-05	15	26	2	19493232
Pubmed	Inhibitory KIR and specific HLA-C gene combinations confer susceptibility to or protection against chronic hepatitis B.	KIR2DS3 KIR2DS5	5.61e-05	15	26	2	20643584
Pubmed	[Killer cell immunoglobin-like receptor and its ligand gene polymorphisms in Hunan Han patients with type 1 diabetes].	KIR2DS3 KIR2DS5	5.61e-05	15	26	2	20356536
Pubmed	Natural killer-cell receptor polymorphisms and posttransplantation non-Hodgkin lymphoma.	KIR2DS3 KIR2DS5	5.61e-05	15	26	2	20207982
Pubmed	[Polymorphism of killer cell immunoglobulin-like receptors gene family in Zhejiang Han population].	KIR2DS3 KIR2DS5	6.41e-05	16	26	2	16403292
Pubmed	Influence of activating and inhibitory killer immunoglobulin-like receptors on predisposition to recurrent miscarriages.	KIR2DS3 KIR2DS5	6.41e-05	16	26	2	19279038
Pubmed	Activating killer cell immunoglobulin-like receptor genes' association with recurrent miscarriage.	KIR2DS3 KIR2DS5	6.41e-05	16	26	2	19527230
Pubmed	Killer cell immunoglobulin-like receptor gene-cluster 3DS1-2DL5-2DS1-2DS5 predisposes susceptibility to Vogt-Koyanagi-Harada syndrome in Japanese individuals.	KIR2DS3 KIR2DS5	6.41e-05	16	26	2	19897003
Pubmed	No association of KIR genes with Behcet's disease.	KIR2DS3 KIR2DS5	6.41e-05	16	26	2	17868255
Pubmed	Report from the killer immunoglobulin-like receptor (KIR) anthropology component of the 15th International Histocompatibility Workshop: worldwide variation in the KIR loci and further evidence for the co-evolution of KIR and HLA.	KIR2DS3 KIR2DS5	6.41e-05	16	26	2	20331834
Pubmed	A study of the killer cell immunoglobulin-like receptor gene KIR2DS1 in a Caucasoid Brazilian population with psoriasis vulgaris.	KIR2DS3 KIR2DS5	6.41e-05	16	26	2	18643961
Pubmed	Polymorphisms of KIR gene and HLA-C alleles: possible association with susceptibility to HLA-B27-positive patients with ankylosing spondylitis.	KIR2DS3 KIR2DS5	6.41e-05	16	26	2	20652381
Pubmed	Distribution of killer cell immunoglobulin-like receptor (KIR) genotypes in patients with familial Mediterranean fever.	KIR2DS3 KIR2DS5	6.41e-05	16	26	2	19309280
Pubmed	Diversity of killer cell immunoglobulin-like receptor genes in Indonesian populations of Java, Kalimantan, Timor and Irian Jaya.	KIR2DS3 KIR2DS5	6.41e-05	16	26	2	19000141
Pubmed	Diversity of killer cell immunoglobulin-like receptor genes in Indonesian populations of Sumatra, Sulawesi and Moluccas Islands.	KIR2DS3 KIR2DS5	6.41e-05	16	26	2	20670355
Pubmed	Asian population frequencies and haplotype distribution of killer cell immunoglobulin-like receptor (KIR) genes among Chinese, Malay, and Indian in Singapore.	KIR2DS3 KIR2DS5	6.41e-05	16	26	2	18668235
Pubmed	HLA-DQA1*0505 sharing and killer immunoglobulin-like receptors in sub fertile couples: report from the 15th International Histocompatibility Workshop.	KIR2DS3 KIR2DS5	6.41e-05	16	26	2	20210919
Pubmed	Killer cell immunoglobulin-like receptor gene diversity in the Tibetan ethnic minority group of China.	KIR2DS3 KIR2DS5	7.26e-05	17	26	2	20650299
Pubmed	KIR genes and KIR ligands affect occurrence of acute GVHD after unrelated, 12/12 HLA matched, hematopoietic stem cell transplantation.	KIR2DS3 KIR2DS5	7.26e-05	17	26	2	19169284
Pubmed	Natural killer cell receptor repertoire and their ligands, and the risk of CMV infection after kidney transplantation.	KIR2DS3 KIR2DS5	7.26e-05	17	26	2	19032228
Pubmed	The beneficial impact of missing KIR ligands and absence of donor KIR2DS3 gene on outcome following unrelated hematopoietic SCT for myeloid leukemia in the Chinese population.	KIR2DS3 KIR2DS5	7.26e-05	17	26	2	20173784
Pubmed	The role of killer immunoglobulin-like receptor haplotypes on the outcome of unrelated donor haematopoietic SCT for thalassaemia.	KIR2DS3 KIR2DS5	7.26e-05	17	26	2	20173792
Pubmed	Killer cell immunoglobulin-like receptor gene polymorphisms in patients with leukemia: possible association with susceptibility to the disease.	KIR2DS3 KIR2DS5	7.26e-05	17	26	2	19450876
Pubmed	[Effects of killer immunoglobulin-like receptor and human leukocyte antigen class I ligand on the prognosis of related donor hematopoietic stem cell transplantation].	KIR2DS3 KIR2DS5	7.26e-05	17	26	2	19968064
Pubmed	Association of KIR2DS1 and KIR2DS3 with fatal outcome in Ebola virus infection.	KIR2DS3 KIR2DS5	7.26e-05	17	26	2	20878400
Pubmed	[Analysis of natural killer cell immunoglobulin-like receptor genes in Chinese].	KIR2DS3 KIR2DS5	7.26e-05	17	26	2	19218127
Pubmed	Role of killer cell immunoglobulin-like receptor gene content and human leukocyte antigen-C group in susceptibility to human T-lymphotropic virus 1-associated myelopathy/tropical spastic paraparesis in Peru.	KIR2DS3 KIR2DS5	7.26e-05	17	26	2	20483367
Pubmed	Distribution of killer-cell immunoglobulin-like receptor genes in Eastern mainland Chinese Han and Taiwanese Han populations.	KIR2DS3 KIR2DS5	7.26e-05	17	26	2	19761533
Pubmed	Killer immunoglobulin-like receptor ligand HLA-Bw4 protects against multiple sclerosis.	KIR2DS3 KIR2DS5	8.16e-05	18	26	2	19630074
Pubmed	Association of killer cell immunoglobulin-like receptors and human leukocyte antigen-C genotypes in South Brazilian with type 1 diabetes.	KIR2DS3 KIR2DS5	8.16e-05	18	26	2	20580654
Pubmed	Influence of HLA class I and HLA-KIR compound genotypes on HIV-2 infection and markers of disease progression in a Manjako community in West Africa.	KIR2DS3 KIR2DS5	8.16e-05	18	26	2	20519398
Pubmed	Combination of KIR 2DL2 and HLA-C1 (Asn 80) confers susceptibility to type 1 diabetes in Latvians.	KIR2DS3 KIR2DS5	8.16e-05	18	26	2	19046302
Pubmed	Signatures of natural selection and coevolution between killer cell immunoglobulin-like receptors (KIR) and HLA class I genes.	KIR2DS3 KIR2DS5	8.16e-05	18	26	2	20200544
Pubmed	Effect of killer immunoglobulin-like receptors in the response to combined treatment in patients with chronic hepatitis C virus infection.	KIR2DS3 KIR2DS5	8.16e-05	18	26	2	19846535
Pubmed	Distribution of killer cell immunoglobulin-like receptor genes in the mestizo population from Venezuela.	KIR2DS3 KIR2DS5	8.16e-05	18	26	2	20210918
Pubmed	Killer cell immunoglobulin-like receptor gene diversity in a Southern Brazilian population from the state of Paraná.	KIR2DS3 KIR2DS5	9.12e-05	19	26	2	18848853
Pubmed	Association between killer-cell immunoglobulin-like receptor genotypes and leprosy in Brazil.	KIR2DS3 KIR2DS5	9.12e-05	19	26	2	18778326
Pubmed	KIR and HLA gene combinations in Vogt-Koyanagi-Harada disease.	KIR2DS3 KIR2DS5	9.12e-05	19	26	2	18571006
Pubmed	Associations between genes for killer immunoglobulin-like receptors and their ligands in patients with solid tumors.	KIR2DS3 KIR2DS5	9.12e-05	19	26	2	20600442
Pubmed	HLA and KIR frequencies in Sicilian Centenarians.	KIR2DS3 KIR2DS5	1.01e-04	20	26	2	20426625
Pubmed	Compound KIR-HLA genotype analyses in the Iranian population by a novel PCR-SSP assay.	KIR2DS3 KIR2DS5	1.01e-04	20	26	2	20193031
Pubmed	Activating killer cell immunoglobulin-like receptors 3DS1 and 2DS1 protect against developing the severe form of recurrent respiratory papillomatosis.	KIR2DS3 KIR2DS5	1.12e-04	21	26	2	19861144
Pubmed	Distribution of KIR genes in the population of unrelated individuals homozygous for ancestral haplotype AH8.1 (HLA-A1B8DR3).	KIR2DS3 KIR2DS5	1.23e-04	22	26	2	20492596
Pubmed	Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.	UNC79 JMJD1C LRP2BP	2.01e-04	153	26	3	10718198
Pubmed	Immunogenetic characteristics of patients with autoimmune gastritis.	KIR2DS3 KIR2DS5	2.15e-04	29	26	2	20082482
Pubmed	Role of human leukocyte antigen, killer-cell immunoglobulin-like receptors, and cytokine gene polymorphisms in leptospirosis.	KIR2DS3 KIR2DS5	3.15e-04	35	26	2	19683555
Cytoband	19q13.4	KIR2DS3 KIR2DS5	9.25e-04	79	26	2	19q13.4
GeneFamily	Myotubularins\|Phosphoinositide phosphatases	MTMR7 MTMR8	6.70e-05	15	15	2	903
GeneFamily	CD molecules\|Killer cell immunoglobulin like receptors	KIR2DS3 KIR2DS5	9.75e-05	18	15	2	620
GeneFamily	Phosphoinositide phosphatases	MTMR7 MTMR8	3.14e-04	32	15	2	1079
Disease	centronuclear myopathy (implicated_via_orthology)	MTMR7 MTMR8	1.01e-05	7	21	2	DOID:14717 (implicated_via_orthology)
Disease	centronuclear myopathy X-linked (implicated_via_orthology)	MTMR7 MTMR8	1.73e-05	9	21	2	DOID:0111225 (implicated_via_orthology)
Disease	Down syndrome (implicated_via_orthology)	DOP1B DYRK2	5.04e-05	15	21	2	DOID:14250 (implicated_via_orthology)
Disease	Charcot-Marie-Tooth disease (implicated_via_orthology)	MTMR7 MTMR8	1.32e-04	24	21	2	DOID:10595 (implicated_via_orthology)
Disease	tyrosine measurement	SHISA9 JMJD1C	2.47e-03	104	21	2	EFO_0005058
Disease	attention deficit hyperactivity disorder, autism spectrum disorder, intelligence	SHISA9 MED27 JMJD1C	2.70e-03	398	21	3	EFO_0003756, EFO_0003888, EFO_0004337
Disease	intelligence, self reported educational attainment	MED27 JMJD1C	3.12e-03	117	21	2	EFO_0004337, EFO_0004784
Disease	puberty onset measurement	UNC79 JMJD1C	3.55e-03	125	21	2	EFO_0005677
Disease	attempted suicide	MYO7B OTUD7A	7.05e-03	178	21	2	EFO_0004321
Disease	neuroticism measurement, cognitive function measurement	ZNF385B MED27 JMJD1C	7.22e-03	566	21	3	EFO_0007660, EFO_0008354
Disease	alcohol use disorder (implicated_via_orthology)	UNC79 JMJD1C	8.40e-03	195	21	2	DOID:1574 (implicated_via_orthology)
Disease	gout	MED27 MEPE	8.48e-03	196	21	2	EFO_0004274

Protein segments in the cluster

Peptide	Gene	Start	Entry
FNEAASKNKQMLPGG	C4orf47	36	A7E2U8
KKLPSAGQGANDMAL	SPECC1L	136	Q69YQ0
EKATEPANGKRQNGM	ANKRD26P1	291	Q6NSI1
EAMSDAKVKNRGNPN	ARMCX4	411	Q5H9R4
AKVKNRGNPNAMTKA	ARMCX4	416	Q5H9R4
RGNPNAMTKAGAKAN	ARMCX4	421	Q5H9R4
QNNSTRNKGMPQGKG	MEPE	476	Q9NQ76
TRPKLNAMANRAAGK	MTMR7	241	Q9Y216
TRPKLNAMANRAAGK	MTMR8	241	Q96EF0
NKKTMAAGDPANLRN	DOP1B	1601	Q9Y3R5
SRGENPKGKNKHLMN	JMJD1C	336	Q15652
AAAAGQGGARKFNMK	LINGO3	576	P0C6S8
NGNPKASVKAQSMLG	LRP2BP	166	Q9P2M1
DKKNASVMDQGPAGN	KIR2DS3	271	Q14952
GKMGRANSANGKNGD	OTUD7A	541	Q8TE49
SANQMGVSAKRRPKA	MED27	136	Q6P2C8
NKKNASVMDQGPAGN	KIR2DS5	271	Q14953
PQARGQGVAAAKQMG	CC2D1B	11	Q5T0F9
EGAGSANENQPKKMF	KIAA1210	1616	Q9ULL0
LNAKKRQGMTGGPNN	DYRK2	186	Q92630
GPAKQNGQKSRTNKM	SHISA9	341	B4DS77
ENGCGNASPQMKARN	RAPGEF3	521	O95398
PGSGLKMNCNNRNVS	SLITRK1	351	Q96PX8
RLKMQNGSKGSGLQN	ZNF385B	331	Q569K4
NGKLKNGNMNEPAEN	USP46	146	P62068
ASQSQAMDKKAQGPG	TMC2	841	Q8TDI7
NNKKNLPAGGAMIRC	UNC79	2136	Q9P2D8
AMNKQRGSKAPALAS	MYO7B	2101	Q6PIF6
NIANMKKKEGAAGNP	NECAP2	161	Q9NVZ3