Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionguanyl-nucleotide exchange factor activity

TRIO MYCBP2 ARHGEF11 ECT2 DIS3 PREX2 DENND3 PREX1

3.02e-052311058GO:0005085
GeneOntologyMolecularFunctionnucleoside-triphosphatase regulator activity

RGPD8 TRIO MYCBP2 RGPD1 ARHGEF11 ECT2 DIS3 PREX2 DENND3 PREX1 RGPD5

7.36e-0550710511GO:0060589
GeneOntologyMolecularFunctionGTPase regulator activity

RGPD8 TRIO MYCBP2 RGPD1 ARHGEF11 ECT2 DIS3 PREX2 DENND3 PREX1 RGPD5

7.36e-0550710511GO:0030695
GeneOntologyMolecularFunctionglutamate receptor activity

GRID1 GRID2 GRIN2B

3.77e-04271053GO:0008066
GeneOntologyCellularComponentpostsynaptic membrane

SEMA4F ERBB3 NAPEPLD SYNE1 GRID1 GRID2 GRIN2B SLC6A6 STRN UTRN

4.06e-0540510610GO:0045211
GeneOntologyCellularComponentcis-Golgi network

HLA-A GOLGA8R GOLGA8N ATP2C1 GOLGA8O

7.25e-05851065GO:0005801
GeneOntologyCellularComponentsynaptic membrane

SEMA4F ERBB3 NAPEPLD SYNE1 GRID1 GRID2 GRIN2B CNTN6 SLC6A6 STRN UTRN

1.83e-0458310611GO:0097060
GeneOntologyCellularComponentGolgi cis cisterna

GOLGA8R GOLGA8N GOLGA8O

6.19e-04331063GO:0000137
GeneOntologyCellularComponentGolgi cisterna

HLA-A GOLGA8R GOLGA8N ATP2C1 GOLGA8O

6.27e-041351065GO:0031985
GeneOntologyCellularComponentcytoplasmic periphery of the nuclear pore complex

RGPD8 RGPD1

6.99e-0481062GO:1990723
GeneOntologyCellularComponentnuclear pore cytoplasmic filaments

RGPD8 RGPD1

1.12e-03101062GO:0044614
GeneOntologyCellularComponentGolgi cisterna membrane

GOLGA8R GOLGA8N ATP2C1 GOLGA8O

1.34e-03941064GO:0032580
GeneOntologyCellularComponentparallel fiber to Purkinje cell synapse

GRID2 GRIN2B CNTN6

1.35e-03431063GO:0098688
DomainGDS_CDC24_CS

TRIO ARHGEF11 ECT2 PREX2 PREX1

2.64e-06391065IPR001331
DomainGrip

RGPD8 RGPD1 RGPD5

2.84e-05111063SM00755
DomainGRIP

RGPD8 RGPD1 RGPD5

2.84e-05111063PF01465
DomainDH_1

TRIO ARHGEF11 ECT2 PREX2 PREX1

2.90e-05631065PS00741
DomainPH_dom-like

RGPD8 TRIO PLEKHF2 RGPD1 ARHGEF11 ECT2 CERT1 PREX2 OSBP PREX1 RGPD5

3.04e-0542610611IPR011993
DomainRRP44_S1

DIS3L DIS3

3.19e-0521062IPR033770
DomainRrp44_S1

DIS3L DIS3

3.19e-0521062PF17215
DomainRan_BP1

RGPD8 RGPD1 RGPD5

3.77e-05121063PF00638
DomainGRIP_dom

RGPD8 RGPD1 RGPD5

3.77e-05121063IPR000237
DomainGRIP

RGPD8 RGPD1 RGPD5

3.77e-05121063PS50913
DomainRANBD1

RGPD8 RGPD1 RGPD5

3.77e-05121063PS50196
Domain-

ZYG11A ARMC3 TOGARAM2 CKAP5 CHIC1 TRRAP XPO5 PDS5A

3.90e-0522210681.25.10.10
DomainRhoGEF

TRIO ARHGEF11 ECT2 PREX2 PREX1

4.20e-05681065SM00325
DomainRhoGEF

TRIO ARHGEF11 ECT2 PREX2 PREX1

4.83e-05701065PF00621
DomainDH_2

TRIO ARHGEF11 ECT2 PREX2 PREX1

4.83e-05701065PS50010
DomainRanBD

RGPD8 RGPD1 RGPD5

4.88e-05131063SM00160
DomainRan_bind_dom

RGPD8 RGPD1 RGPD5

4.88e-05131063IPR000156
DomainDH-domain

TRIO ARHGEF11 ECT2 PREX2 PREX1

5.18e-05711065IPR000219
Domain-

TRIO ARHGEF11 ECT2 PREX2 PREX1

5.18e-057110651.20.900.10
Domain-

RGPD8 TRIO PLEKHF2 RGPD1 ARHGEF11 ECT2 CERT1 PREX2 OSBP PREX1

7.70e-05391106102.30.29.30
DomainZF_BBOX

TRIM49 MYCBP2 TRIM49C TRIM67 TRIM49B

9.18e-05801065PS50119
DomainRrp44_CSD1

DIS3L DIS3

9.54e-0531062IPR033771
DomainRIBONUCLEASE_II

DIS3L DIS3

9.54e-0531062PS01175
DomainRrp44_CSD1

DIS3L DIS3

9.54e-0531062PF17216
DomainZnf_B-box

TRIM49 MYCBP2 TRIM49C TRIM67 TRIM49B

9.74e-05811065IPR000315
DomainIontro_rcpt

GRID1 GRID2 GRIN2B

1.36e-04181063IPR001320
DomainLig_chan-Glu_bd

GRID1 GRID2 GRIN2B

1.36e-04181063PF10613
DomainGOLGA2L5

GOLGA8R GOLGA8N GOLGA8O

1.36e-04181063PF15070
DomainGolgin_A

GOLGA8R GOLGA8N GOLGA8O

1.36e-04181063IPR024858
DomainIono_rcpt_met

GRID1 GRID2 GRIN2B

1.36e-04181063IPR001508
DomainGlu/Gly-bd

GRID1 GRID2 GRIN2B

1.36e-04181063IPR019594
DomainLig_chan-Glu_bd

GRID1 GRID2 GRIN2B

1.36e-04181063SM00918
DomainLig_chan

GRID1 GRID2 GRIN2B

1.36e-04181063PF00060
DomainPBPe

GRID1 GRID2 GRIN2B

1.36e-04181063SM00079
DomainARM-like

ZYG11A ARMC3 TOGARAM2 CKAP5 CHIC1 TRRAP XPO5 PDS5A

1.53e-042701068IPR011989
DomainPH

TRIO PLEKHF2 ARHGEF11 ECT2 CERT1 PREX2 OSBP PREX1

1.86e-042781068SM00233
DomainRNase_II/R_CS

DIS3L DIS3

1.90e-0441062IPR022966
DomainCLASP_N

TOGARAM2 CKAP5

1.90e-0441062PF12348
DomainCLASP_N_dom

TOGARAM2 CKAP5

1.90e-0441062IPR024395
DomainPH_DOMAIN

TRIO PLEKHF2 ARHGEF11 ECT2 CERT1 PREX2 OSBP PREX1

1.91e-042791068PS50003
DomainPH_domain

TRIO PLEKHF2 ARHGEF11 ECT2 CERT1 PREX2 OSBP PREX1

1.96e-042801068IPR001849
DomainSpectrin

TRIO SYNE1 UTRN

2.90e-04231063PF00435
Domain-

TDRD15 RNF17

4.72e-04610622.40.50.90
DomainStaphylococal_nuclease_OB-fold

TDRD15 RNF17

4.72e-0461062IPR016071
DomainIG_LIKE

HLA-A TRIO KIR2DS2 CNTN6 IGSF10 KIR2DS1 KIR2DS3 KIR2DS4 KIR2DS5 KIR3DL1

4.81e-0449110610PS50835
DomainIg-like_dom

HLA-A TRIO KIR2DS2 CNTN6 IGSF10 KIR2DS1 KIR2DS3 KIR2DS4 KIR2DS5 KIR3DL1

5.80e-0450310610IPR007110
DomainSpectrin_repeat

TRIO SYNE1 UTRN

5.83e-04291063IPR002017
DomainBBOX

TRIM49 TRIM49C TRIM67 TRIM49B

6.38e-04691064SM00336
DomainGCC2_Rab_bind

RGPD8 RGPD1

6.58e-0471062IPR032023
DomainAPC_su10/DOC_dom

MYCBP2 HECTD3

6.58e-0471062IPR004939
DomainDOC

MYCBP2 HECTD3

6.58e-0471062PS51284
DomainRab_bind

RGPD8 RGPD1

6.58e-0471062PF16704
DomainAPC10

MYCBP2 HECTD3

6.58e-0471062SM01337
DomainANAPC10

MYCBP2 HECTD3

6.58e-0471062PF03256
DomainIG

TRIO KIR2DS2 CNTN6 IGSF10 KIR2DS1 KIR2DS3 KIR2DS4 KIR2DS5 KIR3DL1

6.59e-044211069SM00409
DomainIg_sub

TRIO KIR2DS2 CNTN6 IGSF10 KIR2DS1 KIR2DS3 KIR2DS4 KIR2DS5 KIR3DL1

6.59e-044211069IPR003599
DomainIg-like_fold

HLA-A TRIO MYCBP2 KIR2DS2 CNTN6 IGSF10 TRIM67 KIR2DS1 KIR2DS3 KIR2DS4 KIR2DS5 KIR3DL1

6.62e-0470610612IPR013783
Domain-

TRIM49 TRIM49C TRIM67 TRIM49B

7.11e-047110644.10.45.10
Domainzf-B_box

TRIM49 TRIM49C TRIM67 TRIM49B

7.50e-04721064PF00643
Domainig

KIR2DS2 KIR2DS1 KIR2DS3 KIR2DS4 KIR2DS5 KIR3DL1

7.53e-041901066PF00047
DomainImmunoglobulin

KIR2DS2 KIR2DS1 KIR2DS3 KIR2DS4 KIR2DS5 KIR3DL1

7.53e-041901066IPR013151
DomainSpectrin/alpha-actinin

TRIO SYNE1 UTRN

7.82e-04321063IPR018159
DomainSPEC

TRIO SYNE1 UTRN

7.82e-04321063SM00150
DomainANF_lig-bd_rcpt

GRID1 GRID2 GRIN2B

1.20e-03371063IPR001828
DomainANF_receptor

GRID1 GRID2 GRIN2B

1.20e-03371063PF01094
Domain-

HLA-A TRIO MYCBP2 KIR2DS2 CNTN6 IGSF10 TRIM67 KIR2DS1 KIR2DS3 KIR2DS4 KIR3DL1

1.36e-03663106112.60.40.10
Domain-

RGPD8 RGPD1

1.39e-031010621.10.220.60
DomainPeripla_BP_I

GRID1 GRID2 GRIN2B

1.40e-03391063IPR028082
DomainSPRY

TRIM49 TRIM49C TRIM67 TRIM49B

1.52e-03871064SM00449
DomainPH

TRIO PLEKHF2 CERT1 PREX2 OSBP PREX1

1.96e-032291066PF00169
DomainSPRY

TRIM49 TRIM49C TRIM67 TRIM49B

2.02e-03941064PF00622
DomainSPRY_dom

TRIM49 TRIM49C TRIM67 TRIM49B

2.02e-03941064IPR003877
DomainB30.2/SPRY

TRIM49 TRIM49C TRIM67 TRIM49B

2.10e-03951064IPR001870
DomainB302_SPRY

TRIM49 TRIM49C TRIM67 TRIM49B

2.10e-03951064PS50188
DomainTUDOR

TDRD15 RNF17

2.78e-03141062PF00567
DomainARM-type_fold

ZYG11A ARMC3 TOGARAM2 CKAP5 TRRAP XPO5 PDS5A

3.21e-033391067IPR016024
DomainBRCT

ECT2 PARP4

5.12e-03191062PF00533
PathwayKEGG_ANTIGEN_PROCESSING_AND_PRESENTATION

HLA-A KIR2DS1 KIR2DS3 KIR2DS4 KIR2DS5 KIR3DL1 HSPA6

3.72e-0788747M16004
PathwayKEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY

HLA-A KIR2DS1 KIR2DS3 KIR2DS4 KIR2DS5 KIR3DL1

8.13e-05137746M5669
PathwayREACTOME_DAP12_INTERACTIONS

KIR2DS2 KIR2DS1 KIR2DS4 KIR2DS5

9.66e-0546744M27151
PathwayPID_RHOA_REG_PATHWAY

CDKN1B TRIO ARHGEF11 ECT2

9.66e-0546744M68
PathwayREACTOME_SIGNALING_BY_RHO_GTPASES_MIRO_GTPASES_AND_RHOBTB3

SEMA4F RGPD8 TRIO RGPD1 CKAP5 ARHGEF11 ECT2 PREX2 GOLGA8N ZNF512B GOLGA8O PREX1

1.31e-046497412MM15690
PathwayREACTOME_CDC42_GTPASE_CYCLE

TRIO ARHGEF11 ECT2 PREX2 PREX1

1.33e-0494745MM15598
PathwayREACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK

TRIO ARHGEF11 ECT2 PREX1

1.57e-0452744MM14743
PathwayREACTOME_CDC42_GTPASE_CYCLE

TRIO GOLGA8R ARHGEF11 ECT2 PREX2 PREX1

1.60e-04155746M41808
PathwayREACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK

TRIO ARHGEF11 ECT2 PREX1

2.56e-0459744M11215
PathwayREACTOME_RHO_GTPASE_CYCLE

SEMA4F TRIO ARHGEF11 ECT2 PREX2 GOLGA8N ZNF512B GOLGA8O PREX1

4.66e-04439749MM15595
PathwayREACTOME_CELL_DEATH_SIGNALLING_VIA_NRAGE_NRIF_AND_NADE

TRIO ARHGEF11 ECT2 PREX1

4.94e-0470744MM14824
PathwayREACTOME_CELL_DEATH_SIGNALLING_VIA_NRAGE_NRIF_AND_NADE

TRIO ARHGEF11 ECT2 PREX1

6.75e-0476744M19832
PathwayREACTOME_G_ALPHA_12_13_SIGNALLING_EVENTS

TRIO ARHGEF11 ECT2 PREX1

7.09e-0477744MM15044
Pubmed

KIR and HLA genotypes are associated with disease progression and survival following autologous hematopoietic stem cell transplantation for high-risk neuroblastoma.

HLA-A KIR2DS2 KIR2DS1 KIR2DS3 KIR2DS4 KIR2DS5 KIR3DL1

4.70e-1513111719934297
Pubmed

Killer cell immunoglobulin-like receptors in HLA-B27-associated acute anterior uveitis, with and without axial spondyloarthropathy.

HLA-A KIR2DS2 KIR2DS1 KIR2DS3 KIR2DS4 KIR2DS5 KIR3DL1

1.75e-1415111719850842
Pubmed

Killer immunoglobulin-like receptors (KIR2DL2 and/or KIR2DS2) in presence of their ligand (HLA-C1 group) protect against chronic myeloid leukaemia.

HLA-A KIR2DS2 KIR2DS1 KIR2DS3 KIR2DS4 KIR2DS5 KIR3DL1

1.75e-1415111719493232
Pubmed

Report from the killer immunoglobulin-like receptor (KIR) anthropology component of the 15th International Histocompatibility Workshop: worldwide variation in the KIR loci and further evidence for the co-evolution of KIR and HLA.

HLA-A KIR2DS2 KIR2DS1 KIR2DS3 KIR2DS4 KIR2DS5 KIR3DL1

3.11e-1416111720331834
Pubmed

The role of killer immunoglobulin-like receptor haplotypes on the outcome of unrelated donor haematopoietic SCT for thalassaemia.

HLA-A KIR2DS2 KIR2DS1 KIR2DS3 KIR2DS4 KIR2DS5 KIR3DL1

5.27e-1417111720173792
Pubmed

Role of killer cell immunoglobulin-like receptor gene content and human leukocyte antigen-C group in susceptibility to human T-lymphotropic virus 1-associated myelopathy/tropical spastic paraparesis in Peru.

HLA-A KIR2DS2 KIR2DS1 KIR2DS3 KIR2DS4 KIR2DS5 KIR3DL1

5.27e-1417111720483367
Pubmed

[Effects of killer immunoglobulin-like receptor and human leukocyte antigen class I ligand on the prognosis of related donor hematopoietic stem cell transplantation].

HLA-A KIR2DS2 KIR2DS1 KIR2DS3 KIR2DS4 KIR2DS5 KIR3DL1

5.27e-1417111719968064
Pubmed

Combination of KIR and HLA gene variants augments the risk of developing birdshot chorioretinopathy in HLA-A*29-positive individuals.

HLA-A KIR2DS2 KIR2DS1 KIR2DS3 KIR2DS4 KIR3DL1

7.68e-149111618340360
Pubmed

Killer immunoglobulin-like receptor ligand HLA-Bw4 protects against multiple sclerosis.

HLA-A KIR2DS2 KIR2DS1 KIR2DS3 KIR2DS4 KIR2DS5 KIR3DL1

8.60e-1418111719630074
Pubmed

Influence of HLA class I and HLA-KIR compound genotypes on HIV-2 infection and markers of disease progression in a Manjako community in West Africa.

HLA-A KIR2DS2 KIR2DS1 KIR2DS3 KIR2DS4 KIR2DS5 KIR3DL1

8.60e-1418111720519398
Pubmed

KIR and HLA gene combinations in Vogt-Koyanagi-Harada disease.

HLA-A KIR2DS2 KIR2DS1 KIR2DS3 KIR2DS4 KIR2DS5 KIR3DL1

1.36e-1319111718571006
Pubmed

Association between killer-cell immunoglobulin-like receptor genotypes and leprosy in Brazil.

HLA-A KIR2DS2 KIR2DS1 KIR2DS3 KIR2DS4 KIR2DS5 KIR3DL1

1.36e-1319111718778326
Pubmed

Associations between genes for killer immunoglobulin-like receptors and their ligands in patients with solid tumors.

HLA-A KIR2DS2 KIR2DS1 KIR2DS3 KIR2DS4 KIR2DS5 KIR3DL1

1.36e-1319111720600442
Pubmed

Killer cell immunoglobulin-like receptor gene diversity in a Southern Brazilian population from the state of ParanĂ¡.

HLA-A KIR2DS2 KIR2DS1 KIR2DS3 KIR2DS4 KIR2DS5 KIR3DL1

1.36e-1319111718848853
Pubmed

Compound KIR-HLA genotype analyses in the Iranian population by a novel PCR-SSP assay.

HLA-A KIR2DS2 KIR2DS1 KIR2DS3 KIR2DS4 KIR2DS5 KIR3DL1

2.09e-1320111720193031
Pubmed

HLA and KIR frequencies in Sicilian Centenarians.

HLA-A KIR2DS2 KIR2DS1 KIR2DS3 KIR2DS4 KIR2DS5 KIR3DL1

2.09e-1320111720426625
Pubmed

In contrast to other stimulatory natural killer cell immunoglobulin-like receptor loci, several KIR2DS5 alleles predominate in African Americans.

KIR2DS2 KIR2DS1 KIR2DS3 KIR2DS4 KIR2DS5

3.02e-135111519410616
Pubmed

Activating killer cell immunoglobulin-like receptors 3DS1 and 2DS1 protect against developing the severe form of recurrent respiratory papillomatosis.

HLA-A KIR2DS2 KIR2DS1 KIR2DS3 KIR2DS4 KIR2DS5 KIR3DL1

3.12e-1321111719861144
Pubmed

[Genotype analysis of killer cell immunoglobulin-like receptors in Graves' disease patients].

KIR2DS2 KIR2DS1 KIR2DS3 KIR2DS4 KIR2DS5 KIR3DL1

4.20e-1311111619664392
Pubmed

Distribution of KIR genes in the population of unrelated individuals homozygous for ancestral haplotype AH8.1 (HLA-A1B8DR3).

HLA-A KIR2DS2 KIR2DS1 KIR2DS3 KIR2DS4 KIR2DS5 KIR3DL1

4.56e-1322111720492596
Pubmed

Association of killer cell immunoglobulin-like receptor 2DL5 with systemic lupus erythematosus and accompanying infections.

KIR2DS2 KIR2DS1 KIR2DS3 KIR2DS4 KIR2DS5 KIR3DL1

8.38e-1312111620371502
Pubmed

Association of killer cell immunoglobulin-like receptors with primary Sjogren's syndrome.

KIR2DS2 KIR2DS1 KIR2DS3 KIR2DS4 KIR2DS5 KIR3DL1

8.38e-1312111619181658
Pubmed

[Relationship between CMV reactivation and KIR haplotype/HLA-Cw genotype in patients after unrelated-donor hematopoietic stem cell transplantation.].

KIR2DS2 KIR2DS1 KIR2DS3 KIR2DS4 KIR2DS5 KIR3DL1

8.38e-1312111620137308
Pubmed

Distribution of killer cell immunoglobulin-like receptors (KIR) and their HLA-C ligands in two Iranian populations.

KIR2DS2 KIR2DS1 KIR2DS3 KIR2DS4 KIR2DS5 KIR3DL1

8.38e-1312111619936734
Pubmed

[Study on the polymorphism of killer cell immunoglobulin like receptor (KIR) gene with systemic lupus erythematosus of North population in China].

KIR2DS2 KIR2DS1 KIR2DS3 KIR2DS4 KIR2DS5 KIR3DL1

1.55e-1213111618687225
Pubmed

Different KIRs confer susceptibility and protection to adults with latent autoimmune diabetes in Latvian and Asian Indian populations.

KIR2DS2 KIR2DS1 KIR2DS3 KIR2DS4 KIR2DS5 KIR3DL1

1.55e-1213111619120281
Pubmed

Frequencies of killer immunoglobulin-like receptor genotypes influence susceptibility to spontaneous abortion.

KIR2DS2 KIR2DS1 KIR2DS3 KIR2DS4 KIR2DS5 KIR3DL1

2.71e-1214111619875891
Pubmed

Multiple sclerosis associates with LILRA3 deletion in Spanish patients.

KIR2DS2 KIR2DS1 KIR2DS3 KIR2DS4 KIR2DS5 KIR3DL1

2.71e-1214111619421224
Pubmed

Distribution of killer cell immunoglobulin-like receptor genes in the Chinese Han population.

KIR2DS2 KIR2DS1 KIR2DS3 KIR2DS4 KIR2DS5 KIR3DL1

2.71e-1214111615896204
Pubmed

Immunogenetic characteristics of patients with autoimmune gastritis.

HLA-A KIR2DS2 KIR2DS1 KIR2DS3 KIR2DS4 KIR2DS5 KIR3DL1

4.10e-1229111720082482
Pubmed

Killer cell immunoglobulin-like receptor gene diversity in a Caucasian population of southern Brazil.

KIR2DS2 KIR2DS1 KIR2DS3 KIR2DS4 KIR2DS5 KIR3DL1

4.51e-1215111620082646
Pubmed

Disparate distribution of activating and inhibitory killer cell immunoglobulin-like receptor genes in patients with systemic lupus erythematosus.

KIR2DS2 KIR2DS1 KIR2DS3 KIR2DS4 KIR2DS5 KIR3DL1

4.51e-1215111619926642
Pubmed

Natural killer-cell receptor polymorphisms and posttransplantation non-Hodgkin lymphoma.

KIR2DS2 KIR2DS1 KIR2DS3 KIR2DS4 KIR2DS5 KIR3DL1

4.51e-1215111620207982
Pubmed

[Killer cell immunoglobin-like receptor and its ligand gene polymorphisms in Hunan Han patients with type 1 diabetes].

KIR2DS2 KIR2DS1 KIR2DS3 KIR2DS4 KIR2DS5 KIR3DL1

4.51e-1215111620356536
Pubmed

Inhibitory KIR and specific HLA-C gene combinations confer susceptibility to or protection against chronic hepatitis B.

KIR2DS2 KIR2DS1 KIR2DS3 KIR2DS4 KIR2DS5 KIR3DL1

4.51e-1215111620643584
Pubmed

KIR genes polymorphism in Argentinean Caucasoid and Amerindian populations.

KIR2DS2 KIR2DS1 KIR2DS3 KIR2DS4 KIR2DS5 KIR3DL1

4.51e-1215111617498266
Pubmed

Killer cell immunoglobulin-like receptor genotype and killer cell immunoglobulin-like receptor-human leukocyte antigen C ligand compatibility affect the severity of hepatitis C virus recurrence after liver transplantation.

KIR2DS2 KIR2DS1 KIR2DS3 KIR2DS4 KIR2DS5 KIR3DL1

4.51e-1215111619326408
Pubmed

Killer cell immunoglobulin-like receptor gene-cluster 3DS1-2DL5-2DS1-2DS5 predisposes susceptibility to Vogt-Koyanagi-Harada syndrome in Japanese individuals.

KIR2DS2 KIR2DS1 KIR2DS3 KIR2DS4 KIR2DS5 KIR3DL1

7.19e-1216111619897003
Pubmed

Diversity of killer cell immunoglobulin-like receptor genes in Indonesian populations of Java, Kalimantan, Timor and Irian Jaya.

KIR2DS2 KIR2DS1 KIR2DS3 KIR2DS4 KIR2DS5 KIR3DL1

7.19e-1216111619000141
Pubmed

Diversity of killer cell immunoglobulin-like receptor genes in Indonesian populations of Sumatra, Sulawesi and Moluccas Islands.

KIR2DS2 KIR2DS1 KIR2DS3 KIR2DS4 KIR2DS5 KIR3DL1

7.19e-1216111620670355
Pubmed

Activating killer cell immunoglobulin-like receptor genes' association with recurrent miscarriage.

KIR2DS2 KIR2DS1 KIR2DS3 KIR2DS4 KIR2DS5 KIR3DL1

7.19e-1216111619527230
Pubmed

Polymorphisms of KIR gene and HLA-C alleles: possible association with susceptibility to HLA-B27-positive patients with ankylosing spondylitis.

KIR2DS2 KIR2DS1 KIR2DS3 KIR2DS4 KIR2DS5 KIR3DL1

7.19e-1216111620652381
Pubmed

Asian population frequencies and haplotype distribution of killer cell immunoglobulin-like receptor (KIR) genes among Chinese, Malay, and Indian in Singapore.

KIR2DS2 KIR2DS1 KIR2DS3 KIR2DS4 KIR2DS5 KIR3DL1

7.19e-1216111618668235
Pubmed

Influence of activating and inhibitory killer immunoglobulin-like receptors on predisposition to recurrent miscarriages.

KIR2DS2 KIR2DS1 KIR2DS3 KIR2DS4 KIR2DS5 KIR3DL1

7.19e-1216111619279038
Pubmed

No association of KIR genes with Behcet's disease.

KIR2DS2 KIR2DS1 KIR2DS3 KIR2DS4 KIR2DS5 KIR3DL1

7.19e-1216111617868255
Pubmed

A study of the killer cell immunoglobulin-like receptor gene KIR2DS1 in a Caucasoid Brazilian population with psoriasis vulgaris.

KIR2DS2 KIR2DS1 KIR2DS3 KIR2DS4 KIR2DS5 KIR3DL1

7.19e-1216111618643961
Pubmed

Distribution of killer cell immunoglobulin-like receptor (KIR) genotypes in patients with familial Mediterranean fever.

KIR2DS2 KIR2DS1 KIR2DS3 KIR2DS4 KIR2DS5 KIR3DL1

7.19e-1216111619309280
Pubmed

[Polymorphism of killer cell immunoglobulin-like receptors gene family in Zhejiang Han population].

KIR2DS2 KIR2DS1 KIR2DS3 KIR2DS4 KIR2DS5 KIR3DL1

7.19e-1216111616403292
Pubmed

HLA-DQA1*0505 sharing and killer immunoglobulin-like receptors in sub fertile couples: report from the 15th International Histocompatibility Workshop.

KIR2DS2 KIR2DS1 KIR2DS3 KIR2DS4 KIR2DS5 KIR3DL1

7.19e-1216111620210919
Pubmed

The beneficial impact of missing KIR ligands and absence of donor KIR2DS3 gene on outcome following unrelated hematopoietic SCT for myeloid leukemia in the Chinese population.

HLA-A KIR2DS2 KIR2DS1 KIR2DS3 KIR2DS4 KIR2DS5

1.11e-1117111620173784
Pubmed

[Analysis of natural killer cell immunoglobulin-like receptor genes in Chinese].

KIR2DS2 KIR2DS1 KIR2DS3 KIR2DS4 KIR2DS5 KIR3DL1

1.11e-1117111619218127
Pubmed

KIR genes and KIR ligands affect occurrence of acute GVHD after unrelated, 12/12 HLA matched, hematopoietic stem cell transplantation.

KIR2DS2 KIR2DS1 KIR2DS3 KIR2DS4 KIR2DS5 KIR3DL1

1.11e-1117111619169284
Pubmed

Association of KIR2DS1 and KIR2DS3 with fatal outcome in Ebola virus infection.

KIR2DS2 KIR2DS1 KIR2DS3 KIR2DS4 KIR2DS5 KIR3DL1

1.11e-1117111620878400
Pubmed

Killer cell immunoglobulin-like receptor gene diversity in the Tibetan ethnic minority group of China.

KIR2DS2 KIR2DS1 KIR2DS3 KIR2DS4 KIR2DS5 KIR3DL1

1.11e-1117111620650299
Pubmed

Killer cell immunoglobulin-like receptor gene polymorphisms in patients with leukemia: possible association with susceptibility to the disease.

KIR2DS2 KIR2DS1 KIR2DS3 KIR2DS4 KIR2DS5 KIR3DL1

1.11e-1117111619450876
Pubmed

Distribution of killer-cell immunoglobulin-like receptor genes in Eastern mainland Chinese Han and Taiwanese Han populations.

KIR2DS2 KIR2DS1 KIR2DS3 KIR2DS4 KIR2DS5 KIR3DL1

1.11e-1117111619761533
Pubmed

Signatures of natural selection and coevolution between killer cell immunoglobulin-like receptors (KIR) and HLA class I genes.

KIR2DS2 KIR2DS1 KIR2DS3 KIR2DS4 KIR2DS5 KIR3DL1

1.66e-1118111620200544
Pubmed

Combination of KIR 2DL2 and HLA-C1 (Asn 80) confers susceptibility to type 1 diabetes in Latvians.

KIR2DS2 KIR2DS1 KIR2DS3 KIR2DS4 KIR2DS5 KIR3DL1

1.66e-1118111619046302
Pubmed

Effect of killer immunoglobulin-like receptors in the response to combined treatment in patients with chronic hepatitis C virus infection.

KIR2DS2 KIR2DS1 KIR2DS3 KIR2DS4 KIR2DS5 KIR3DL1

1.66e-1118111619846535
Pubmed

Association of killer cell immunoglobulin-like receptors and human leukocyte antigen-C genotypes in South Brazilian with type 1 diabetes.

KIR2DS2 KIR2DS1 KIR2DS3 KIR2DS4 KIR2DS5 KIR3DL1

1.66e-1118111620580654
Pubmed

Distribution of killer cell immunoglobulin-like receptor genes in the mestizo population from Venezuela.

HLA-A KIR2DS2 KIR2DS3 KIR2DS4 KIR2DS5 KIR3DL1

1.66e-1118111620210918
Pubmed

NullHap--a versatile application to estimate haplotype frequencies from unphased genotypes in the presence of null alleles.

KIR2DS2 KIR2DS1 KIR2DS3 KIR2DS4 KIR2DS5

1.68e-118111518681957
Pubmed

Role of human leukocyte antigen, killer-cell immunoglobulin-like receptors, and cytokine gene polymorphisms in leptospirosis.

HLA-A KIR2DS2 KIR2DS1 KIR2DS3 KIR2DS4 KIR2DS5 KIR3DL1

1.74e-1135111719683555
Pubmed

Molecular clones of the p58 NK cell receptor reveal immunoglobulin-related molecules with diversity in both the extra- and intracellular domains.

KIR2DS2 KIR2DS3 KIR2DS4 KIR2DS5 KIR3DL1

3.77e-11911157749980
Pubmed

Alternatively spliced forms of human killer inhibitory receptors.

KIR2DS2 KIR2DS3 KIR2DS4 KIR2DS5 KIR3DL1

3.77e-11911158662091
Pubmed

Different patterns of evolution in the centromeric and telomeric regions of group A and B haplotypes of the human killer cell Ig-like receptor locus.

KIR2DS1 KIR2DS3 KIR2DS4 KIR2DS5 KIR3DL1

7.52e-1110111521206914
Pubmed

Assessment of killer cell immunoglobulinlike receptor expression and corresponding HLA class I phenotypes demonstrates heterogenous KIR expression independent of anticipated HLA class I ligands.

KIR2DS2 KIR2DS1 KIR2DS3 KIR2DS5 KIR3DL1

7.52e-1110111512559621
Pubmed

Natural killer cells and immune surveillance.

KIR2DS2 KIR2DS3 KIR2DS4 KIR2DS5 KIR3DL1

1.38e-1011111518830515
Pubmed

[Genotype and haplotype analysis of killer cell immunoglobulin-like receptors in ankylosing spondylitis].

KIR2DS2 KIR2DS1 KIR2DS3 KIR2DS4 KIR3DL1

5.92e-1014111519489269
Pubmed

Donors with group B KIR haplotypes improve relapse-free survival after unrelated hematopoietic cell transplantation for acute myelogenous leukemia.

KIR2DS2 KIR2DS1 KIR2DS4 KIR2DS5 KIR3DL1

5.92e-1014111518945962
Pubmed

Killer cell immunoglobulin-like receptor gene polymorphism in lymphoproliferative diseases of granular lymphocytes in a Japanese population.

KIR2DS2 KIR2DS1 KIR2DS3 KIR3DL1

1.47e-096111420528243
Pubmed

Natural killer cell receptor repertoire and their ligands, and the risk of CMV infection after kidney transplantation.

KIR2DS1 KIR2DS3 KIR2DS4 KIR2DS5 KIR3DL1

1.81e-0917111519032228
Pubmed

Activation of a subset of human NK cells upon contact with Plasmodium falciparum-infected erythrocytes.

KIR2DS2 KIR2DS4 KIR2DS5 KIR3DL1

3.41e-097111414607943
Pubmed

A novel surface molecule homologous to the p58/p50 family of receptors is selectively expressed on a subset of human natural killer cells and induces both triggering of cell functions and proliferation.

KIR2DS3 KIR2DS4 KIR2DS5

3.16e-08311138765026
Pubmed

Activating killer immunoglobulin-like receptor incompatibilities enhance graft-versus-host disease and affect survival after allogeneic hematopoietic stem cell transplantation.

KIR2DS1 KIR2DS3 KIR2DS5

3.16e-083111319500138
Pubmed

[Polymorphism of killer cell immunoglobulin-like receptor gene and its correlation with leukemia].

KIR2DS2 KIR2DS4 KIR2DS5 KIR3DL1

4.77e-0812111417490516
Pubmed

E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.

SEMA4F TOPAZ1 CKAP5 ECT2 IGSF10 SLC6A6 PARP4 SAMD9L MDN1 SLC22A16 AGL PDS5A UTRN BANK1

1.01e-077361111429676528
Pubmed

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.

NR2C2 TSHZ3 RGPD8 MYCBP2 RGPD1 CKAP5 IKBKG POGZ UTRN HSPA6 KNL1

1.07e-074181111134709266
Pubmed

A role for KIR gene variants other than KIR2DS1 in conferring susceptibility to psoriasis.

KIR2DS1 KIR2DS3 KIR2DS5

1.26e-074111316829306
Pubmed

Diversity of the repertoire of p58 killer cell inhibitory receptors in a single individual.

KIR2DS2 KIR2DS1 KIR2DS4

3.15e-075111310424431
Pubmed

Identification of a genomic reservoir for new TRIM genes in primate genomes.

TRIM49 TRIM49C TRIM49B TRIM51G

3.67e-0719111422144910
Pubmed

Associations of killer cell immunoglobulin-like receptor genes with complications of rheumatoid arthritis.

KIR2DS2 KIR2DS1 KIR2DS3

6.28e-076111317882223
Pubmed

Complex genomic rearrangements lead to novel primate gene function.

RGPD8 RGPD1 RGPD5

1.10e-067111315710750
Pubmed

Identification of seventeen novel KIR variants: fourteen of them from two non-Caucasian donors.

KIR2DS2 KIR2DS1 KIR2DS4

1.10e-067111311169255
Pubmed

Functionally and structurally distinct NK cell receptor repertoires in the peripheral blood of two human donors.

KIR2DS1 KIR2DS3 KIR3DL1

1.10e-06711139430220
Pubmed

KIR haplotype content at the allele level in 77 Northern Irish families.

KIR2DS2 KIR2DS4 KIR3DL1

1.75e-068111317200871
Pubmed

Human diversity in killer cell inhibitory receptor genes.

KIR2DS1 KIR2DS3 KIR3DL1

1.75e-06811139430221
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

KIF21B RGPD8 TRIO MYCBP2 SYNE1 RGPD1 CKAP5 GRIN2B ARHGEF11 GOLGA8N STRN MDN1 TRIM67 GOLGA8O

2.47e-069631111428671696
Pubmed

Polymorphisms of killer cell immunoglobulin-like receptor gene: possible association with susceptibility to or clearance of hepatitis B virus infection in Chinese Han population.

KIR2DS2 KIR2DS1 KIR2DS3

2.62e-069111318074414
Pubmed

The deubiquitinase TRABID stabilizes the K29/K48-specific E3 ubiquitin ligase HECTD1.

TRIO MYCBP2 HECTD3 IKBKG TRRAP STRN PDS5A

5.62e-06212111733853758
Pubmed

Proximity labeling of endogenous RICTOR identifies mTOR complex 2 regulation by ADP ribosylation factor ARF1.

RGPD8 RGPD1 CKAP5 DIS3 STRN UTRN RGPD5

6.17e-06215111735973513
Pubmed

Protein kinase D negatively regulates hepatitis C virus secretion through phosphorylation of oxysterol-binding protein and ceramide transfer protein.

CERT1 OSBP

1.01e-052111221285358
Pubmed

Extracellular domain alterations impact surface expression of stimulatory natural killer cell receptor KIR2DS5.

KIR2DS1 KIR2DS5

1.01e-052111218682925
Pubmed

Association of KIR gene polymorphisms with COVID-19 disease.

KIR2DS4 KIR3DL1

1.01e-052111234929414
Pubmed

Impact of activating killer immunoglobulin-like receptor genotype on outcome of unrelated donor-hematopoietic cell transplantation.

KIR2DS2 KIR2DS1

1.01e-052111216504727
Pubmed

Dimorphic motifs in D0 and D1+D2 domains of killer cell Ig-like receptor 3DL1 combine to form receptors with high, moderate, and no avidity for the complex of a peptide derived from HIV and HLA-A*2402.

HLA-A KIR3DL1

1.01e-052111219752231
Pubmed

Novel insights in the genomic organization and hotspots of recombination in the human KIR locus through analysis of intergenic regions.

KIR2DS4 KIR3DL1

1.01e-052111225503311
Pubmed

The presence of KIR2DS5 confers protection against adult immune thrombocytopenia.

KIR2DS2 KIR2DS5

1.01e-052111224571473
Pubmed

P-Rex1 and P-Rex2 RacGEFs and cancer.

PREX2 PREX1

1.01e-052111228710285
Pubmed

Cutting Edge: Allele-specific and peptide-dependent interactions between KIR3DL1 and HLA-A and HLA-B.

HLA-A KIR3DL1

1.01e-052111217182537
InteractionKIR2DS2 interactions

KIR2DS2 KIR2DS1 KIR2DS3 KIR2DS5 KIR3DL1

1.40e-06371065int:KIR2DS2
InteractionRAN interactions

NR2C2 RGPD8 MYCBP2 RGPD1 IKBKG DIS3 IGSF10 TRIM67 XPO5 AGL HSPA6 RGPD5

7.58e-0647510612int:RAN
Cytoband19q13.4

KIR2DS2 KIR2DS1 KIR2DS3 KIR2DS4 KIR2DS5 KIR3DL1

4.20e-0879111619q13.4
GeneFamilyCD molecules|Killer cell immunoglobulin like receptors

KIR2DS2 KIR2DS1 KIR2DS3 KIR2DS4 KIR2DS5 KIR3DL1

8.72e-1118776620
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

TRIO ARHGEF11 ECT2 PREX2 PREX1

8.96e-0666775722
GeneFamilyGlutamate ionotropic receptor delta type subunits

GRID1 GRID2

1.79e-0527721202
GeneFamilyRing finger proteins|Tripartite motif containing|ARF GTPase family

TRIM49 TRIM49C TRIM67 TRIM49B TRIM51G

5.28e-059577559
GeneFamilyExosome complex

DIS3L DIS3

1.15e-0312772817
GeneFamilyWD repeat domain containing|Protein phosphatase 2 regulatory subunits

PPP2R3B STRN

1.81e-0315772696
GeneFamilySynaptotagmins

SYT16 SYT14

2.34e-0317772765
GeneFamilyWD repeat domain containing

KIF21B DCAF4L2 DENND3 STRN WDHD1

5.20e-03262775362
GeneFamilyRing finger proteins

TRIM49 TRIM49C RNF17 TRIM67 TRIM49B

6.36e-0327577558
GeneFamilyADAM metallopeptidase domain containing|CD molecules

KIR2DS2 CDCP1 KIR2DS1 KIR2DS4 KIR2DS5 KIR3DL1

6.66e-03394776471
CoexpressionKAZMIN_PBMC_P_FALCIPARUM_RTSS_AS01_AGE_UNKNOWN_CORRELATED_WITH_PROTECTION_56DY_NEGATIVE

KIR2DS2 KIR2DS1 KIR2DS3 KIR2DS5 KIR3DL1

1.79e-06491085M40909
ToppCellCOVID-19-COVID-19_Mild-Lymphocyte-T/NK-NK_activated|COVID-19_Mild / Disease, condition lineage and cell class

KIF21B SYNE1 GOLGA8R SAMD9L KIR3DL1 GOLGA8O UTRN

5.53e-0720010772281debd86e5d92e8fe0397aec9ef670800f7471
ToppCellFetal_29-31_weeks-Epithelial-ciliated_cell-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

IQANK1 ARMC3 TOGARAM2 CCDC81 LGSN LRRIQ1

5.03e-061811076dfce05bd472f67e6e2bb60ebd6fd34f0a9aeeca6
ToppCellPND10|World / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MYCBP2 PREX2 SLC6A6 KLHL5 UTRN BANK1

6.65e-061901076d67e2814047c8df2ae4b7bc8be9539f5df6ecef2
ToppCell5'-GW_trimst-1.5-SmallIntestine-Neuronal-Glial_immature-Glia_1_(DHH+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ERBB3 GRIN2B CERT1 CNTN6 ADGRG6 PREX1

7.27e-0619310763ea6b103e35bbb276e95301999618558fa3e38b1
ToppCellCOVID_non-vent-Lymphocytic-ILC|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

SYNE1 GOLGA8R GOLGA8N KIR3DL1 GOLGA8O UTRN

8.66e-061991076df4f7d5be099e3e6054f3b812ccf70251664e4c0
ToppCellCOVID_vent-Lymphocytic-ILC|COVID_vent / Disease condition, Lineage, Cell class and subclass

SYNE1 GOLGA8R GOLGA8N KIR3DL1 GOLGA8O UTRN

8.66e-061991076e3ff7fa1b1de1aaf6b46cdf49afa95bad457728a
ToppCellCOVID_non-vent-Lymphocytic-ILC-NK_cell|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

SYNE1 GOLGA8R GOLGA8N KIR3DL1 GOLGA8O UTRN

8.66e-061991076ed35d747f11f6ea6a5cb7061057f0a98d9e0db99
ToppCellCOVID_vent-Lymphocytic-ILC-NK_cell|COVID_vent / Disease condition, Lineage, Cell class and subclass

SYNE1 GOLGA8R GOLGA8N KIR3DL1 GOLGA8O UTRN

8.66e-0619910765f914962e2572b0c6372465b81b7496fa663d93c
ToppCellTCGA-Peripheral_Nervous_System-Primary_Tumor-Paraganglioma-Paraganglioma-3|TCGA-Peripheral_Nervous_System / Sample_Type by Project: Shred V9

ARMT1 TRIO SYNE1 CERT1 PPIP5K2

1.88e-051351075ac20133d4a36f48338b45bffb13e842cb66f83ad
ToppCellControl-Epithelial_airway-Ciliated_cells-Ciliated|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ARMC3 TOGARAM2 CCDC81 LRRIQ1 SLC22A16

3.53e-0515410754e3bc24043144143842627cacf6f90dda2228910
ToppCellControl-Epithelial_airway-Ciliated_cells|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ARMC3 TOGARAM2 CCDC81 LRRIQ1 SLC22A16

3.53e-0515410757556a4b2b062da5ae7ec2bbb66e745e7662db628
ToppCellsaliva-Severe-critical_progression_d12-22_with-steroid-Myeloid-Macrophage-macrophage,_alveolar-Macro_c2-CCL3L1|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

CCDC81 ZNF512B PARP4 SAMD9L MDN1

4.63e-051631075130c84bca3f72ab7d1a4fee2990c3d01600318ed
ToppCellControl-T/NK_proliferative|World / Disease group and Cell class

ZNF268 PPP2R3B CDCP1 XPO5 KNL1

5.50e-051691075fca735cbb55fce4d32dc6632a39acea1d16b87ab
ToppCelldroplet-Limb_Muscle-MUSCLE-30m|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SYNE1 PREX2 SAMD9L ELK4 UTRN

7.03e-05178107501dafd19de04eff459253eaa9a35debf8f3deedf
ToppCellFetal_29-31_weeks-Epithelial-ciliated_cell-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ARMC3 TOGARAM2 CCDC81 LGSN LRRIQ1

7.03e-051781075de5d50d7ca9ee9eb62f50c88a0c6d47f0694b2e6
ToppCelldroplet-Liver-LIVER_HEP-30m|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYCBP2 PREX2 DENND3 IGSF10 ABCC8

7.41e-051801075dd1b10c7f5a0fbc63163844ca1882884a24a84d3
ToppCelldroplet-Liver-LIVER_HEP|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYCBP2 PREX2 DENND3 IGSF10 ABCC8

7.41e-051801075423454e3390080ae03bb3cbb267255ebfe4df080
ToppCellPND10-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PREX2 DENND3 ADGRG6 SLC6A6 UTRN

7.61e-0518110754d7793026373cbcf04b15c77f95f1025d07d4c00
ToppCelldroplet-Spleen-nan-18m|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CDKN1B MYCBP2 SAMD9L ELK4 BANK1

7.81e-051821075eeb5dfa4539e9ca5220f26bc2b65717ddcf13b6c
ToppCellPND10-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PREX2 DENND3 ADGRG6 SLC6A6 UTRN

8.01e-0518310753427f3cbe6ea81709750e7dd3ff378f03ae65eab
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L5-6_SST_ISOC1|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TSHZ3 GRID2 KLHL5 TRIM49B UTRN

8.43e-051851075ae53aa2ecfe418a5dbd7d963a995bc06dab94f56
ToppCell3'-GW_trimst-1-SmallIntestine-Neuronal-Glial_immature-Glia_1_(DHH+)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ERBB3 GRID2 CERT1 CNTN6 ADGRG6

8.43e-051851075dd17025d8c423aa0a451ac7f1f301c93528e0229
ToppCell5'-GW_trimst-1.5-LargeIntestine-Hematopoietic-B_cells-Pro-B|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PPP2R3B CCDC81 DENND3 SLC22A16 BANK1

8.65e-0518610754a5264e32ba004ed58dc4102d84e4bc4dbbe1440
ToppCelldroplet-Heart-nan-3m-Endothelial|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CERT1 PREX2 SAMD9L ELK4 UTRN

8.65e-0518610750ae5fbe9f210cb25092394267e1d3d6ed05627b8
ToppCell5'-GW_trimst-1.5-LargeIntestine-Hematopoietic-B_cells|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PPP2R3B CCDC81 DENND3 SLC22A16 BANK1

8.65e-051861075528ee88f6e27863c7bcdffd4416cbbd83fc65e9d
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TRIO SYNE1 PARP4 STRN UTRN

9.09e-05188107563a4b25a0a6e05f80f1a6dd91b817f3cf49e6b68
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Deuterosomal|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ARMC3 ECT2 LRRIQ1 IQCC KNL1

9.56e-051901075da60bcc4b59d8e3719d8201387d567594059b1a4
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Deuterosomal-Deuterosomal_L.0.3.4.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ARMC3 ECT2 LRRIQ1 IQCC KNL1

9.56e-051901075827a1f4e4ac4beada262f4fb965dd74a447a8f4f
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TSHZ3 ADGRG6 KLHL5 TRIM67 UTRN

1.00e-041921075dc40ef2341e5d6a6d479f140e023fe1bf687928d
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TSHZ3 GRID2 ADGRG6 KLHL5 TRIM67

1.03e-041931075d1445b8bf2bab36e1a326ddb2a528151db016c7d
ToppCellTCGA-Endometrium-Primary_Tumor-Endometrial_Adenocarcinoma-Endometrioid-1|TCGA-Endometrium / Sample_Type by Project: Shred V9

CKAP5 SLC6A6 WDHD1 PDS5A KNL1

1.03e-041931075c2673d86f7d7b849788036032a93a6d136a70040
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L4-6_SST_MTHFD2P6|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TSHZ3 GRID2 PREX2 KLHL5 TRIM67

1.03e-0419310758b77625bf3c87d39767fb391d1beaca4ab02342b
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TSHZ3 GRID2 ADGRG6 KLHL5 TRIM67

1.03e-0419310753ed46f5a7419ec4eddbd0df0d9b5f53aa486198b
ToppCellIPF-Endothelial-VE_Capillary_A|Endothelial / Disease state, Lineage and Cell class

HLA-A SYNE1 KLHL5 SAMD9L PREX1

1.05e-041941075777ce41c3f22c591e2d81120f189b834e53ffb4b
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L3-5_SST_MAFB|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TSHZ3 GRID2 ADGRG6 KLHL5 TRIM67

1.05e-0419410751bcb3fafd498614f7bac2b1c9b7de56e39110f65
ToppCellSmart-seq2-tissue-resident_(Smart-seq2)-lymphocytic-innate_lymphocytic-mature_NK_T_cell|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

HLA-A SYNE1 KIR2DS4 KIR3DL1 UTRN

1.05e-041941075ae5357e2a276473cde1fc8c43acaf9f69da35fd7
ToppCellSmart-seq2-tissue-resident_(Smart-seq2)-lymphocytic-innate_lymphocytic|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

HLA-A SYNE1 KIR2DS4 KIR3DL1 UTRN

1.05e-0419410753a0b8b5d0354c43da57bb951cd8ba878363c3de5
ToppCellmild-B_cell|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

ZYG11A POGZ DIS3 IQCC BANK1

1.08e-0419510751e5f1967bcc898318f4e970b844b4a944eb168e5
ToppCellCOVID-19-T_cells-Cycling_NK/T_cells|COVID-19 / group, cell type (main and fine annotations)

CKAP5 ECT2 WDHD1 SLC22A16 KNL1

1.08e-041951075764ed100c28d9bc93ee5ecabc5291c8f184d78da
ToppCellCOVID-19-Heart-EC_1|Heart / Disease (COVID-19 only), tissue and cell type

HLA-A SYNE1 PREX2 KLHL5 UTRN

1.08e-04195107550a193475db1bb1e05b8590225a553688c372c14
ToppCellNS-control-d_0-4-Epithelial-Ciliated|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

ARMC3 SYNE1 TOGARAM2 CCDC81 LRRIQ1

1.11e-041961075d46ab80554dd3c1cc81e1938ea2acfd5e85c6d2a
ToppCell(05)_Ciliated|World / shred by cell type and Timepoint

ARMC3 SYNE1 TOGARAM2 FBXO36 CCDC81

1.13e-041971075fee3cd16af8eea697cd64e8f64af505aaa2ac4b0
ToppCell3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SYNE1 TOGARAM2 CCDC81 LGSN LRRIQ1

1.13e-04197107574a2c6cb8fcfe53dd9a2b36492a16c58f38e51c9
ToppCellCOVID-19_Severe-NK_activated|World / disease group, cell group and cell class

HLA-A SYNE1 SAMD9L KIR3DL1 UTRN

1.13e-041971075a60db36d1a192998e3ded63e0c7c08d41689f95f
ToppCellLV-09._Endothelium_I|LV / Chamber and Cluster_Paper

HLA-A SYNE1 PREX2 KLHL5 UTRN

1.13e-041971075f9731d4d636e51b94a96805eee6afe9aedc175e3
ToppCellhealthy_donor-Lymphocytic-ILC-NK_cell|healthy_donor / Disease condition, Lineage, Cell class and subclass

HLA-A SYNE1 GOLGA8R GOLGA8N UTRN

1.16e-041981075d7053a898e04478c577381085f615edaad3cdc5b
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SYNE1 PREX2 KLHL5 UTRN PREX1

1.16e-041981075451003a21162eeae90739fdb502bb50b362d80c8
ToppCellhealthy_donor-Lymphocytic-ILC|healthy_donor / Disease condition, Lineage, Cell class and subclass

HLA-A SYNE1 GOLGA8R GOLGA8N UTRN

1.16e-041981075aa33be29e26f1b8facfc894413099083ae3bbb1b
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Endothelial|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SYNE1 PREX2 KLHL5 UTRN PREX1

1.16e-041981075440af8f90c7afa1c07000806bcf9110b70f489fb
ToppCellCOVID-19_Moderate-NK|World / disease group, cell group and cell class

HLA-A SYNE1 TOGARAM2 KIR3DL1 UTRN

1.19e-041991075c41b67b760831c7d5e19fabcc932a056dc560f93
DrugD-Au

HLA-A KIR2DS1 KIR2DS3 KIR2DS4 KIR2DS5 KIR3DL1

1.60e-06771066CID000277822
DrugAa1

SYNE1 KIR2DS1 KIR2DS3 KIR2DS4 KIR2DS5 KIR3DL1

2.49e-06831066CID009549188
Drugp-terphenyl

CDKN1B TRIO SYNE1 SLC22A16 AGL KIR3DL1

8.76e-061031066CID000007115
Diseaseblood pressure

SYNE1 PREX1 BANK1

5.72e-05221013EFO_0004325
DiseaseInsulinogenic index measurement

MYCBP2 PPIP5K2

1.15e-0451012EFO_0009961
DiseaseNeurodevelopmental Disorders

TRIO POGZ GRIN2B CERT1

2.99e-04931014C1535926
Diseaseribose-5-phosphate measurement, ribulose-5-phosphate measurement

ACOT9 GRID2

3.20e-0481012EFO_0010529, EFO_0010530
Diseasecholesterol:total lipids ratio, intermediate density lipoprotein measurement

TDRD15 HLA-A CERT1 BANK1

8.08e-041211014EFO_0008595, EFO_0020943
DiseaseIntellectual Disability

TRIO ACOT9 SYNE1 POGZ GRIN2B CERT1 TRRAP

8.84e-044471017C3714756
Diseasetransitional cell carcinoma (is_marker_for)

CDKN1B ERBB3 XPO5

1.33e-03631013DOID:2671 (is_marker_for)
Diseaseidiopathic scoliosis (implicated_via_orthology)

PPP2R3B ADGRG6

1.35e-03161012DOID:0060250 (implicated_via_orthology)
Diseasecognitive function measurement, self reported educational attainment

MYCBP2 PEF1 PPA2 PREX1 BANK1 KNL1

1.41e-033551016EFO_0004784, EFO_0008354
Diseaselymphocyte count

CDKN1B ERBB3 HLA-A ARHGEF11 PREX2 DENND3 PPA2 ELK4 PPIP5K2 KIR2DS4 PREX1 HSPA6 KNL1

1.47e-03146410113EFO_0004587
Diseaseselenium measurement, response to dietary selenium supplementation

TRIO CNTN6

2.12e-03201012EFO_0006331, EFO_0600021
Diseaseattention deficit hyperactivity disorder, autism spectrum disorder, intelligence

TSHZ3 GRID2 PEF1 PPA2 PREX1 BANK1

2.51e-033981016EFO_0003756, EFO_0003888, EFO_0004337
Diseasetriglyceride measurement, high density lipoprotein cholesterol measurement

TDRD15 HLA-A ECT2 SYT14 ANXA10

2.55e-032741015EFO_0004530, EFO_0004612
Diseasecholangiocarcinoma (is_implicated_in)

PREX2 WDHD1

2.56e-03221012DOID:4947 (is_implicated_in)
DiseaseNasopharyngeal carcinoma

ERBB3 SYNE1

2.56e-03221012C2931822
Diseasehip bone mineral density, fat body mass

DCAF4L2 GRID1

2.56e-03221012EFO_0005409, EFO_0007702
Diseaseresponse to selective serotonin reuptake inhibitor

TSHZ3 GRIN2B PREX1

2.83e-03821013EFO_0005658
Diseasebrain measurement, neuroimaging measurement

KIF21B ERBB3 RGPD1 DENND3 STRN LRRIQ1 MAEL

2.87e-035501017EFO_0004346, EFO_0004464
Diseaseresponse to anticonvulsant

TDRD15 HLA-A PREX2

3.14e-03851013GO_0036277

Protein segments in the cluster

PeptideGeneStartEntry
HLLQCSGATWASKMK

BANK1

361

Q8NDB2
MEHLWSLLSNCKKTR

ARMT1

226

Q9H993
IEQVKHSNHKWMSKC

ARMT1

301

Q9H993
KNDKLCHMDTIDWRD

ERBB3

151

P21860
WEACQQKTGEHKTML

ANXA10

181

Q9UJ72
RLWMNVEKTISCTDH

CDCP1

406

Q9H5V8
AMKENVQKQWRQHLC

ADGRG6

1116

Q86SQ4
SKEMQASRQWIHVAC

GPR33

191

Q49SQ1
IEIHNSWCEAMKKLR

ARHGEF11

786

O15085
DQPCVKRWSAMHEAA

ASB15

171

Q8WXK1
VWMENSKLKSLEICH

ACOT9

286

Q9Y305
QGTMNRLLTSWHKCK

CALHM1

296

Q8IU99
SKNDEVRKHASWAVM

ARMC3

491

Q5W041
QMSEWALLKRHQCED

DUS3L

346

Q96G46
EKHCRDMEEASQRKW

CDKN1B

46

P46527
NLKTECDLWHLMVKE

DENND3

796

A2RUS2
EDKHSQCKWVMGSIL

TMEM37

116

Q8WXS4
SEQKWMAVKCVHRTQ

ATP2C1

456

P98194
KQVMEHIWKLQEFCN

NR2C2

466

P49116
HIWKLQEFCNSMAKL

NR2C2

471

P49116
AMWRKILQNCHDDAA

PPP2R3B

201

Q9Y5P8
ALNEMWKCQNMLRSH

PDS5A

501

Q29RF7
KVCANHWITTTMNLK

RGPD5

1106

Q99666
KVCANHWITTTMNLK

RGPD8

1106

O14715
ENWLKMLCRHVANTI

ECT2

781

Q9H8V3
LCRDHSSWLQMKQNR

IQCC

116

Q4KMZ1
HRWCSNKKNAAVMDQ

KIR2DS2

266

P43631
KREKWCHMTQEERDD

KIAA0513

336

O60268
HCIELMVKREDSWQK

CERT1

261

Q9Y5P4
HRWCSDKKNAAVMDQ

KIR2DS4

266

P43632
LNCWSMSLDNTMKRH

MDN1

3816

Q9NU22
KSDDRTRVNWCLKHM

MAEL

216

Q96JY0
TRVNWCLKHMAKASE

MAEL

221

Q96JY0
VSCMQRKKVQIHSWD

DCAF4L2

51

Q8NA75
HLWCSNKKNAAVMDQ

KIR3DL1

361

P43629
KLEDRKWHSMASLSC

GRID2

341

O43424
KWHSMASLSCIRKNS

GRID2

346

O43424
DMLQLWCHASEREKK

PNMA6E

346

A0A0J9YXQ4
KDRSCKMWNLVTGQE

KIF21B

1326

O75037
SHRFAKLCMSDKLWE

FBXO36

121

Q8NEA4
NERWVLTAAHCKMNE

KLK7

61

P49862
MNRHLWKSQLCEMVQ

IKBKG

1

Q9Y6K9
LVDINKNLWEKMRHC

KNL1

1971

Q8NG31
HRWCSDKKNASVMDQ

KIR2DS3

266

Q14952
SKHSWRKQIEDQMTR

PARP4

1031

Q9UKK3
HTNKWTLCAQMSKRR

KLHL5

631

Q96PQ7
CRDFLMLAQTHSKKW

OSBP

276

P22059
MKELKQALVNCNWSS

PEF1

136

Q9UBV8
QEEEEKRHCWMKQFK

LRRIQ1

201

Q96JM4
HRWCSNKKNASVMDQ

KIR2DS5

266

Q14953
SNWKERLACMEEFQK

CKAP5

611

Q14008
KWTMISRDNNTKLEH

IGSF10

471

Q6WRI0
KHMICWTSNDGQFKL

ELK4

21

P28324
QCLQEDWERSAAMKK

CCDC81

581

Q6ZN84
HLKFRTTRKWNGCMQ

GPR32P1

176

Q8NGA4
VAECMILANHWVAKK

DIS3L

681

Q8TF46
MGFSCRQKTWHKITD

ADGRF2

131

Q8IZF7
NSKLCLNWEHVKTME

CNTN6

916

Q9UQ52
DMAAQITKRKWEAAH

HLA-A

161

P04439
TKWNKHMMDTRDCQV

KCTD6

161

Q8NC69
RKWHSMASLNCIRKS

GRID1

341

Q9ULK0
KMQDKCREVLAWLEH

HSPA6

571

P17066
RWHQRMSKMSQEICT

GOLGA8R

251

I6L899
RWHQRMSKMSQEICT

GOLGA8O

251

A6NCC3
LHWKLTKRKCETSNM

CHIC1

191

Q5VXU3
HNMWLKCVSLKRNDF

KBTBD6

501

Q86V97
HSLWDVDRKKNMFCS

LGSN

316

Q5TDP6
ATEKSEWMNHINKCV

PLEKHF2

116

Q9H8W4
EWMNHINKCVTDLLS

PLEKHF2

121

Q9H8W4
KVCANHWITTTMNLK

RGPD1

1091

P0DJD0
HRWCSDKKNAAVMDQ

KIR2DS1

266

Q14954
IICWLTKAEHAMQKR

UTRN

2096

P46939
ASEDHTLKMWNLQKT

STRN

481

O43815
LQKMQSLWEKACENH

TRIM49

141

P0CI25
TEMKESKGQQVCRWH

SYT14

536

Q8NB59
WNTPHCMEDTMRKNK

SLC6A6

166

P31641
DWMVPEAHRQNCRKK

SEMA4F

101

O95754
RHCNMVLENVKEMWT

SNRPD2

61

P62316
EEMKETKGQQICRWH

SYT16

626

Q17RD7
RMKWESLHQEFSTKQ

SYNE1

6296

Q8NF91
CSLKQMVHEGNQRWD

SYNE1

8076

Q8NF91
VAMKNLADNHWAKTC

BMT2

76

Q1RMZ1
CEFLKKHDQKWEVNM

TDRD15

1441

B5MCY1
KHDQKWEVNMICDEK

TDRD15

1446

B5MCY1
ISWQYLHCNDEKMQK

TOGARAM2

216

Q6ZUX3
KASDHGWVCDQRVMK

MRM3

301

Q9HC36
FHQLCVDQWLAMSKK

RNF165

316

Q6ZSG1
AMHVLWDLKKNFRCA

SAMD9L

751

Q8IVG5
KIVDIMAKWNRASSC

SLC22A16

306

Q86VW1
RVWQKHTACQRSKGM

POGZ

1211

Q7Z3K3
IHNTAKNKWFVCMAK

PREX1

361

Q8TCU6
MALRCWSLKFKQSDH

MYCBP2

3676

O75592
EVIKSTHQCWKALLM

PPA2

266

Q9H2U2
HDQCEWRCMDKTKLT

IQANK1

346

A8MXQ7
SCIWEMNHNAEILKT

DIS3

561

Q9Y2L1
CQLFEHWKTLMNRQD

ABCC8

921

Q09428
VKWENDMHCAVKIQD

RNF17

961

Q9BXT8
DMHCAVKIQDKNQWR

RNF17

966

Q9BXT8
KMVWDQINHCTLKLR

TRIM67

421

Q6ZTA4
CLEQGKDPWNMKRHS

ZNF738

86

Q8NE65
GKAFCWKSQLIMHQR

ZNF268

926

Q14587
VWNVETKDCMERVKH

WDHD1

256

O75717
LQKMQSLWEKACENH

TRIM49C

141

P0CI26
VTWDCMKTQLSEAVH

TMEM214

651

Q6NUQ4
DWVSMSHITAENCKL

XPO5

236

Q9HAV4
HNTAKNKWFVCMAKT

PREX2

331

Q70Z35
WHFEARKSQILKCME

TSHZ3

376

Q63HK5
ERHMISSWEQKNNCV

TPGS2

46

Q68CL5
SLEHCSALKWLKENM

TOPAZ1

1666

Q8N9V7
SKTQLEKHRIWNHMD

ZNF512B

151

Q96KM6
SLWRKMCENHRNLNM

TRIM51G

146

A0A3B3IT33
WKCKDHTEMLQENQG

ZNF140

121

P52738
LQKMQSLWEKACENH

TRIM49B

141

A6NDI0
LCNESKDEQWKRAMD

PPIP5K2

841

O43314
DAAKFVMRWLCKHEN

ZYG11A

466

Q6WRX3
NNSLHDMKTVVKTWR

TRRAP

2961

Q9Y4A5
RDCAEKVASHWQQLM

TRIO

986

O75962
CNWFHKRMEELNSEK

AGL

371

P35573
RWHQRMSKMSQEICT

GOLGA8N

251

F8WBI6
QCQHWVRLTMKKGTI

HECTD3

276

Q5T447
SQHWCKRTLMDDNKV

NAPEPLD

251

Q6IQ20
WLTGICHNEKNEVMS

GRIN2B

796

Q13224