Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	trace-amine receptor activity	TAAR3P TAAR9 TAAR8	4.40e-06	8	87	3	GO:0001594
GeneOntologyMolecularFunction	steroid 11-beta-monooxygenase activity	CYP11B1 CYP11B2	1.88e-05	2	87	2	GO:0004507
GeneOntologyMolecularFunction	corticosterone 18-monooxygenase activity	CYP11B1 CYP11B2	1.88e-05	2	87	2	GO:0047783
GeneOntologyMolecularFunction	G protein-coupled receptor activity	OR6B1 GPR3 OXTR SLC39A9 OR6C75 MRGPRF FPR3 RXFP2 TAAR3P TAAR9 ADGRF4 OR4X2 TAAR8	1.13e-04	884	87	13	GO:0004930
GeneOntologyMolecularFunction	steroid hydroxylase activity	CYP1B1 CYP11B1 CYP11B2	4.34e-04	34	87	3	GO:0008395
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	OR6B1 GPR3 TRPV1 OXTR SLC39A9 ABCC8 OR6C75 MRGPRF FPR3 RXFP2 TAAR3P TAAR9 ADGRF4 OR4X2 TAAR8	6.96e-04	1353	87	15	GO:0004888
GeneOntologyMolecularFunction	G protein-coupled amine receptor activity	TAAR3P TAAR9 TAAR8	7.56e-04	41	87	3	GO:0008227
GeneOntologyMolecularFunction	transition metal ion transmembrane transporter activity	SLC39A9 ATP13A1 SLC39A6	9.30e-04	44	87	3	GO:0046915
GeneOntologyMolecularFunction	nuclear export signal receptor activity	RANBP17 XPO4	1.20e-03	12	87	2	GO:0005049
GeneOntologyMolecularFunction	ABC-type transporter activity	ABCA13 ATP13A1 ABCC8	1.27e-03	49	87	3	GO:0140359
GeneOntologyMolecularFunction	ATPase-coupled transmembrane transporter activity	ATP6V1H ABCA13 ATP13A1 ABCC8	1.32e-03	109	87	4	GO:0042626
GeneOntologyMolecularFunction	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen	CYP11B1 CYP11B2	1.42e-03	13	87	2	GO:0016713
MousePheno	abnormal urine progesterone level	CYP11B1 CYP11B2	2.26e-05	2	67	2	MP:0011545
MousePheno	abnormal urine deoxycorticosterone level	CYP11B1 CYP11B2	2.26e-05	2	67	2	MP:0011552
MousePheno	decreased urine corticosterone level	CYP11B1 CYP11B2	2.26e-05	2	67	2	MP:0011550
MousePheno	increased urine deoxycorticosterone level	CYP11B1 CYP11B2	2.26e-05	2	67	2	MP:0011553
MousePheno	increased urine progesterone level	CYP11B1 CYP11B2	2.26e-05	2	67	2	MP:0011546
MousePheno	abnormal adrenal gland zona glomerulosa morphology	CYP11B1 CYP11B2	1.35e-04	4	67	2	MP:0008293
MousePheno	decreased urine aldosterone level	CYP11B1 CYP11B2	1.35e-04	4	67	2	MP:0011541
MousePheno	abnormal urine aldosterone level	CYP11B1 CYP11B2	1.35e-04	4	67	2	MP:0011539
MousePheno	abnormal urine corticosterone level	CYP11B1 CYP11B2	1.35e-04	4	67	2	MP:0011548
MousePheno	decreased urine hormone level	CYP11B1 CYP11B2	1.35e-04	4	67	2	MP:0014459
MousePheno	increased adrenal gland zona fasciculata size	CYP11B1 CYP11B2	2.24e-04	5	67	2	MP:0014286
MousePheno	short outer hair cell stereocilia	WHRN MYO15A	2.24e-04	5	67	2	MP:0004531
MousePheno	abnormal outer hair cell stereocilia length	WHRN MYO15A	2.24e-04	5	67	2	MP:0014411
MousePheno	uterus adenomyosis	CYP11B1 CYP11B2	3.35e-04	6	67	2	MP:0009221
MousePheno	increased urine hormone level	CYP11B1 CYP11B2	3.35e-04	6	67	2	MP:0014458
MousePheno	adrenal gland hyperplasia	CYP11B1 CYP11B2	3.35e-04	6	67	2	MP:0009078
MousePheno	abnormal sensory neuron physiology	WHRN TRPV1 FPR3 MYO15A	3.88e-04	72	67	4	MP:0010055
MousePheno	short photoreceptor outer segment	WHRN RP1L1 AGPAT3 OAT	4.54e-04	75	67	4	MP:0008587
MousePheno	abnormal urine hormone level	CYP11B1 CYP11B2	4.68e-04	7	67	2	MP:0011538
MousePheno	pituitary gland hyperplasia	CYP11B1 CYP11B2	4.68e-04	7	67	2	MP:0000635
MousePheno	abnormal photoreceptor outer segment size	WHRN RP1L1 AGPAT3 OAT	5.27e-04	78	67	4	MP:0020811
MousePheno	enlarged adrenal glands	WHRN CYP11B1 CYP11B2	5.66e-04	34	67	3	MP:0000642
MousePheno	increased circulating angiotensin II level	CYP11B1 CYP11B2	6.22e-04	8	67	2	MP:0031232
MousePheno	increased angiotensin II level	CYP11B1 CYP11B2	6.22e-04	8	67	2	MP:0031229
MousePheno	short inner hair cell stereocilia	WHRN MYO15A	6.22e-04	8	67	2	MP:0004536
MousePheno	abnormal somatic nervous system physiology	WHRN TRPV1 FPR3 MYO15A	6.66e-04	83	67	4	MP:0005423
MousePheno	decreased thymus weight	WHRN CYP11B1 CYP11B2	6.71e-04	36	67	3	MP:0004956
MousePheno	abnormal cochlear hair cell inter-stereocilial links morphology	WHRN MYO15A	7.97e-04	9	67	2	MP:0004577
MousePheno	decreased fluid intake	TRPV1 CYP11B1 CYP11B2	9.85e-04	41	67	3	MP:0011942
MousePheno	decreased circulating renin level	CYP11B1 CYP11B2	9.93e-04	10	67	2	MP:0003353
MousePheno	abnormal adrenocortical cell morphology	CYP11B1 CYP11B2	9.93e-04	10	67	2	MP:0008291
MousePheno	disorganized photoreceptor inner segment	AGPAT3 OAT	9.93e-04	10	67	2	MP:0008581
Domain	TAAR_fam	TAAR3P TAAR9 TAAR8	3.14e-06	7	85	3	IPR009132
Domain	-	RANBP17 ATP6V1H NF1 IPO7 INTS4 XPO4 TTI1 ARMCX1	7.70e-06	222	85	8	1.25.10.10
Domain	Cyt_P450_mitochondrial	CYP11B1 CYP11B2	2.05e-05	2	85	2	IPR002399
Domain	ARM-type_fold	RANBP17 ATP6V1H NF1 IPO7 INTS4 XPO4 TTI1 ARMH3 ARMCX1	2.36e-05	339	85	9	IPR016024
Domain	ARM-like	RANBP17 ATP6V1H NF1 IPO7 INTS4 XPO4 TTI1 ARMCX1	3.16e-05	270	85	8	IPR011989
Domain	7tm_1	OR6B1 GPR3 OXTR OR6C75 MRGPRF FPR3 RXFP2 TAAR3P TAAR9 OR4X2 TAAR8	2.44e-04	677	85	11	PF00001
Domain	G_PROTEIN_RECEP_F1_1	OR6B1 GPR3 OXTR OR6C75 MRGPRF FPR3 RXFP2 TAAR3P TAAR9 OR4X2 TAAR8	2.70e-04	685	85	11	PS00237
Domain	G_PROTEIN_RECEP_F1_2	OR6B1 GPR3 OXTR OR6C75 MRGPRF FPR3 RXFP2 TAAR3P TAAR9 OR4X2 TAAR8	2.90e-04	691	85	11	PS50262
Domain	GPCR_Rhodpsn	OR6B1 GPR3 OXTR OR6C75 MRGPRF FPR3 RXFP2 TAAR3P TAAR9 OR4X2 TAAR8	2.94e-04	692	85	11	IPR000276
Domain	DC	DCDC1 RP1L1	5.63e-04	8	85	2	PS50309
Domain	Doublecortin_dom	DCDC1 RP1L1	5.63e-04	8	85	2	IPR003533
Domain	BPI1	BPIFB1 BPIFB6	7.22e-04	9	85	2	SM00328
Domain	LBP_BPI_CETP_C	BPIFB1 BPIFB6	9.00e-04	10	85	2	PF02886
Domain	GPCR_Rhodpsn_7TM	OR6B1 GPR3 OXTR OR6C75 MRGPRF FPR3 RXFP2 TAAR9 OR4X2 TAAR8	9.15e-04	670	85	10	IPR017452
Domain	Lipid-bd_serum_glycop_C	BPIFB1 BPIFB6	1.31e-03	12	85	2	IPR001124
Domain	LBP_BPI_CETP	BPIFB1 BPIFB6	1.55e-03	13	85	2	PF01273
Domain	BPI/LBP/Plunc	BPIFB1 BPIFB6	1.55e-03	13	85	2	IPR032942
Domain	Bactericidal_perm-incr_a/b_dom	BPIFB1 BPIFB6	1.55e-03	13	85	2	IPR017943
Domain	Lipid-bd_serum_glycop_N	BPIFB1 BPIFB6	1.55e-03	13	85	2	IPR017942
Domain	Zip	SLC39A9 SLC39A6	1.80e-03	14	85	2	PF02535
Domain	ZIP	SLC39A9 SLC39A6	1.80e-03	14	85	2	IPR003689
Domain	Cyt_P450_CS	CYP1B1 CYP11B1 CYP11B2	1.81e-03	53	85	3	IPR017972
Domain	IBN_N	RANBP17 IPO7	2.07e-03	15	85	2	PF03810
Domain	CYTOCHROME_P450	CYP1B1 CYP11B1 CYP11B2	2.23e-03	57	85	3	PS00086
Domain	-	CYP1B1 CYP11B1 CYP11B2	2.34e-03	58	85	3	1.10.630.10
Domain	p450	CYP1B1 CYP11B1 CYP11B2	2.34e-03	58	85	3	PF00067
Domain	IBN_N	RANBP17 IPO7	2.36e-03	16	85	2	SM00913
Domain	Cyt_P450	CYP1B1 CYP11B1 CYP11B2	2.58e-03	60	85	3	IPR001128
Domain	Importin-beta_N	RANBP17 IPO7	2.66e-03	17	85	2	IPR001494
Pathway	KEGG_STEROID_HORMONE_BIOSYNTHESIS	CYP1B1 CYP11B1 CYP11B2 UGT2A3	1.04e-04	55	63	4	M14933
Pathway	REACTOME_ENDOGENOUS_STEROLS	CYP1B1 CYP11B1 CYP11B2	1.82e-04	25	63	3	M11184
Pathway	KEGG_MEDICUS_REFERENCE_STEROID_HORMONE_BIOSYNTHESIS_PROGESTERONE_TO_CORTISOL_CORTISONE	CYP11B1 CYP11B2	1.95e-04	5	63	2	M47522
Pathway	REACTOME_ENDOGENOUS_STEROLS	CYP1B1 CYP11B1 CYP11B2	2.30e-04	27	63	3	MM14844
Pathway	REACTOME_METABOLIC_DISORDERS_OF_BIOLOGICAL_OXIDATION_ENZYMES	CYP1B1 CYP11B1 CYP11B2	4.61e-04	34	63	3	M27461
Pathway	WP_METAPATHWAY_BIOTRANSFORMATION	CYP1B1 CYP11B1 CYP11B2 CHST4 UGT2A3	5.97e-04	153	63	5	MM15844
Pathway	WP_GPCRS_ODORANT	GPR3 MRGPRF TAAR3P TAAR9 ADGRF4	6.72e-04	157	63	5	MM15872
Pathway	REACTOME_CLASS_A_1_RHODOPSIN_LIKE_RECEPTORS	OXTR FPR3 RXFP2 TAAR3P TAAR9 TAC1 TAAR8	6.85e-04	333	63	7	MM14963
Pathway	REACTOME_AMINE_LIGAND_BINDING_RECEPTORS	TAAR3P TAAR9 TAAR8	8.62e-04	42	63	3	MM14971
Pathway	REACTOME_GLUCOCORTICOID_BIOSYNTHESIS	CYP11B1 CYP11B2	8.64e-04	10	63	2	M27076
Pathway	WP_OXIDATION_BY_CYTOCHROME_P450	CYP1B1 CYP11B1 CYP11B2	9.24e-04	43	63	3	MM15873
Pathway	REACTOME_GLUCOCORTICOID_BIOSYNTHESIS	CYP11B1 CYP11B2	1.05e-03	11	63	2	MM14750
Pathway	REACTOME_MINERALOCORTICOID_BIOSYNTHESIS	CYP11B1 CYP11B2	1.26e-03	12	63	2	MM14749
Pathway	KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	TRPV1 OXTR FPR3 RXFP2 TAAR9 TAAR8	1.32e-03	272	63	6	M13380
Pathway	WP_METAPATHWAY_BIOTRANSFORMATION_PHASE_I_AND_II	CYP1B1 CYP11B1 CYP11B2 CHST4 UGT2A3	1.33e-03	183	63	5	M39588
Pathway	WP_GLUCOCORTICOID_BIOSYNTHESIS	CYP11B1 CYP11B2	1.73e-03	14	63	2	M46449
Pathway	WP_MINERALOCORTICOID_BIOSYNTHESIS	CYP11B1 CYP11B2	1.73e-03	14	63	2	M46453
Pubmed	Genes related to sex steroids, neural growth, and social-emotional behavior are associated with autistic traits, empathy, and Asperger syndrome.	CYP1B1 TRPV1 OXTR CYP11B1 TAC1	6.77e-07	65	88	5	19598235
Pubmed	Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors.	TAAR3P TAAR9 TAAR8	1.30e-06	9	88	3	15718104
Pubmed	A second class of chemosensory receptors in the olfactory epithelium.	TAAR3P TAAR9 TAAR8	1.30e-06	9	88	3	16878137
Pubmed	Expression of trace amine-associated receptors in the Grueneberg ganglion.	TAAR3P TAAR9 TAAR8	1.85e-06	10	88	3	17556730
Pubmed	Phenotypic consequences of variation across the aldosterone synthase and 11-beta hydroxylase locus in a hypertensive cohort: data from the MRC BRIGHT Study.	CYP11B1 CYP11B2	6.33e-06	2	88	2	17651452
Pubmed	Common polymorphisms in the CYP11B1 and CYP11B2 genes: evidence for a digenic influence on hypertension.	CYP11B1 CYP11B2	6.33e-06	2	88	2	23150505
Pubmed	Expression of CYP11B1 and CYP11B2 in adrenal adenoma correlates with clinical characteristics of primary aldosteronism.	CYP11B1 CYP11B2	6.33e-06	2	88	2	34743356
Pubmed	GRAde: a long-read sequencing approach to efficiently identifying the CYP11B1/CYP11B2 chimeric form in patients with glucocorticoid-remediable aldosteronism.	CYP11B1 CYP11B2	6.33e-06	2	88	2	35012455
Pubmed	Role of genetic variation in regulation of aldosterone biosynthesis.	CYP11B1 CYP11B2	6.33e-06	2	88	2	21164264
Pubmed	Whirlin increases TRPV1 channel expression and cellular stability.	WHRN TRPV1	6.33e-06	2	88	2	26516054
Pubmed	Expression of substance P and vanilloid receptor (VR1) in trigeminal sensory neurons projecting to the mouse nasal mucosa.	TRPV1 TAC1	6.33e-06	2	88	2	12906843
Pubmed	Polymorphisms in CYP11B2 and CYP11B1 genes associated with primary hyperaldosteronism.	CYP11B1 CYP11B2	6.33e-06	2	88	2	20339375
Pubmed	Predictive models for breast cancer susceptibility from multiple single nucleotide polymorphisms.	CYP1B1 CYP11B2	6.33e-06	2	88	2	15102677
Pubmed	Genetic analyses of the chimeric CYP11B1/CYP11B2 gene in a Korean family with glucocorticoid-remediable aldosteronism.	CYP11B1 CYP11B2	6.33e-06	2	88	2	20808686
Pubmed	The hamster adrenal cytochrome P450C11 has equipotent 11beta-hydroxylase and 19-hydroxylase activities, but no aldosterone synthase activity.	CYP11B1 CYP11B2	6.33e-06	2	88	2	8645611
Pubmed	Effect of genetic deletion of the vanilloid receptor TRPV1 on the expression of Substance P in sensory neurons of mice with adjuvant-induced arthritis.	TRPV1 TAC1	6.33e-06	2	88	2	20303589
Pubmed	Expression and localization of cytochrome P450(11beta,aldo) mRNA in the frog brain.	CYP11B1 CYP11B2	6.33e-06	2	88	2	12231255
Pubmed	A de novo unequal cross-over mutation between CYP11B1 and CYP11B2 genes causes familial hyperaldosteronism type I.	CYP11B1 CYP11B2	6.33e-06	2	88	2	20634641
Pubmed	Mutant analysis reveals whirlin as a dynamic organizer in the growing hair cell stereocilium.	WHRN MYO15A	6.33e-06	2	88	2	15590699
Pubmed	Hereditary hypertension caused by chimaeric gene duplications and ectopic expression of aldosterone synthase.	CYP11B1 CYP11B2	6.33e-06	2	88	2	1303253
Pubmed	Aldosterone decreases glucose-stimulated insulin secretion in vivo in mice and in murine islets.	CYP11B1 CYP11B2	6.33e-06	2	88	2	21519965
Pubmed	Diagnosis of glucocorticoid-remediable aldosteronism in hypertensive children.	CYP11B1 CYP11B2	6.33e-06	2	88	2	21625068
Pubmed	Discovery of a null mutation in a human trace amine receptor gene.	TAAR3P TAAR9	6.33e-06	2	88	2	14559210
Pubmed	Genetic screening for glucocorticoid-remediable aldosteronism (GRA): experience of three clinical centres in Poland.	CYP11B1 CYP11B2	6.33e-06	2	88	2	16110193
Pubmed	Chimeric CYP11B2/CYP11B1 causing 11β-hydroxylase deficiency in Chinese patients with congenital adrenal hyperplasia.	CYP11B1 CYP11B2	6.33e-06	2	88	2	26066897
Pubmed	Role of steroid 11 beta-hydroxylase and steroid 18-hydroxylase in the biosynthesis of glucocorticoids and mineralocorticoids in humans.	CYP11B1 CYP11B2	6.33e-06	2	88	2	1741400
Pubmed	Whirler mutant hair cells have less severe pathology than shaker 2 or double mutants.	WHRN MYO15A	6.33e-06	2	88	2	17619105
Pubmed	Effects of intron conversion in the human CYP11B2 gene on its transcription and blood pressure regulation in transgenic mice.	CYP11B1 CYP11B2	6.33e-06	2	88	2	32540969
Pubmed	Inhibition of aldosterone synthase (CYP11B2) by torasemide prevents atrial fibrosis and atrial fibrillation in mice.	CYP11B1 CYP11B2	6.33e-06	2	88	2	26047574
Pubmed	The proximodistal aggravation of colitis depends on substance P released from TRPV1-expressing sensory neurons.	TRPV1 TAC1	6.33e-06	2	88	2	22080974
Pubmed	Aldosterone synthase knockout mouse as a model for sodium-induced endothelial sodium channel up-regulation in vascular endothelium.	CYP11B1 CYP11B2	6.33e-06	2	88	2	26324851
Pubmed	Cytotoxicity and decreased corticosterone production in adrenocortical Y-1 cells by 3-methylsulfonyl-DDE and structurally related molecules.	CYP11B1 CYP11B2	6.33e-06	2	88	2	18651133
Pubmed	Microsatellite polymorphism analysis allows the individual assignment of the rat 11 beta-hydroxylase gene (Cyp11b1) and the rat aldosterone synthase gene (Cyp11b2) to chromosome 7 using rat x mouse somatic cell hybrids and identifies differences between and within various rat strains.	CYP11B1 CYP11B2	6.33e-06	2	88	2	7669222
Pubmed	A new presentation of the chimeric CYP11B1/CYP11B2 gene with low prevalence of primary aldosteronism and atypical gene segregation pattern.	CYP11B1 CYP11B2	6.33e-06	2	88	2	22083159
Pubmed	Aldosterone-dependent and -independent regulation of the epithelial sodium channel (ENaC) in mouse distal nephron.	CYP11B1 CYP11B2	6.33e-06	2	88	2	22933298
Pubmed	Structural and functional analysis of the promoter region of the gene encoding mouse steroid 11 beta-hydroxylase.	CYP11B1 CYP11B2	6.33e-06	2	88	2	2783417
Pubmed	Cloning and expression of a cDNA for human cytochrome P-450aldo as related to primary aldosteronism.	CYP11B1 CYP11B2	6.33e-06	2	88	2	2256920
Pubmed	Editorial: polymorphisms in CYP11B genes and 11-hydroxylase activity.	CYP11B1 CYP11B2	6.33e-06	2	88	2	15699546
Pubmed	Cyp11b1 is induced in the murine gonad by luteinizing hormone/human chorionic gonadotropin and involved in the production of 11-ketotestosterone, a major fish androgen: conservation and evolution of the androgen metabolic pathway.	CYP11B1 CYP11B2	6.33e-06	2	88	2	18162527
Pubmed	Chronic activation of adrenal Gq signaling induces Cyp11b2 expression in the zona fasciculata and hyperaldosteronism.	CYP11B1 CYP11B2	6.33e-06	2	88	2	38341019
Pubmed	Association of DNA polymorphisms within the CYP11B2/CYP11B1 locus and postoperative hypertension risk in the patients with aldosterone-producing adenomas.	CYP11B1 CYP11B2	6.33e-06	2	88	2	20708777
Pubmed	Molecular genetic studies on the biosynthesis of aldosterone in humans.	CYP11B1 CYP11B2	6.33e-06	2	88	2	22217843
Pubmed	Mechanistic study of polychlorinated biphenyl 126-induced CYP11B1 and CYP11B2 up-regulation.	CYP11B1 CYP11B2	6.33e-06	2	88	2	16396990
Pubmed	Adrenal CYP11B1/2 expression in primary aldosteronism: immunohistochemical analysis using novel monoclonal antibodies.	CYP11B1 CYP11B2	6.33e-06	2	88	2	24837548
Pubmed	Aldosterone deficiency in mice burdens respiration and accentuates diet-induced hyperinsulinemia and obesity.	CYP11B1 CYP11B2	6.33e-06	2	88	2	30046010
Pubmed	Familial and phenotypic associations of the aldosterone Renin ratio.	CYP11B1 CYP11B2	6.33e-06	2	88	2	19820005
Pubmed	A novel DFNB31 mutation associated with Usher type 2 syndrome showing variable degrees of auditory loss in a consanguineous Portuguese family.	WHRN EYS	6.33e-06	2	88	2	21738389
Pubmed	[123 I]Iodometomidate for molecular imaging of adrenocortical cytochrome P450 family 11B enzymes.	CYP11B1 CYP11B2	6.33e-06	2	88	2	18397978
Pubmed	Glucocorticoid-suppressible hyperaldosteronism results from hybrid genes created by unequal crossovers between CYP11B1 and CYP11B2.	CYP11B1 CYP11B2	6.33e-06	2	88	2	1518866
Pubmed	Aldosterone deficiency and mineralocorticoid receptor antagonism prevent angiotensin II-induced cardiac, renal, and vascular injury.	CYP11B1 CYP11B2	6.33e-06	2	88	2	22622494
Pubmed	Mutation analysis of CYP11B1 and CYP11B2 in patients with increased 18-hydroxycortisol production.	CYP11B1 CYP11B2	6.33e-06	2	88	2	15062555
Pubmed	Procollagen I-expressing renin cell precursors.	CYP11B1 CYP11B2	6.33e-06	2	88	2	23761669
Pubmed	Disturbed homeostasis in sodium-restricted mice heterozygous and homozygous for aldosterone synthase gene disruption.	CYP11B1 CYP11B2	6.33e-06	2	88	2	17075030
Pubmed	Polymorphic variation in the 11beta-hydroxylase gene associates with reduced 11-hydroxylase efficiency.	CYP11B1 CYP11B2	6.33e-06	2	88	2	17075029
Pubmed	Characterization of two genes encoding human steroid 11 beta-hydroxylase (P-450(11) beta).	CYP11B1 CYP11B2	6.33e-06	2	88	2	2592361
Pubmed	CYP11B2-CYP11B1 haplotypes associated with decreased 11 beta-hydroxylase activity.	CYP11B1 CYP11B2	6.33e-06	2	88	2	15507509
Pubmed	Polymorphism of CYP11B2 determines salt sensitivity in Japanese.	CYP11B1 CYP11B2	6.33e-06	2	88	2	17296872
Pubmed	Aldosterone deficiency prevents high-fat-feeding-induced hyperglycaemia and adipocyte dysfunction in mice.	CYP11B1 CYP11B2	6.33e-06	2	88	2	23314847
Pubmed	Effect of variation in CYP11B1 and CYP11B2 on corticosteroid phenotype and hypothalamic-pituitary-adrenal axis activity in hypertensive and normotensive subjects.	CYP11B1 CYP11B2	6.33e-06	2	88	2	17980006
Pubmed	Association between aldosterone production and variation in the 11beta-hydroxylase (CYP11B1) gene.	CYP11B1 CYP11B2	6.33e-06	2	88	2	16984984
Pubmed	Evidence for local aldosterone synthesis in the large intestine of the mouse.	CYP11B1 CYP11B2	6.33e-06	2	88	2	35288482
Pubmed	Homeostatic responses in the adrenal cortex to the absence of aldosterone in mice.	CYP11B1 CYP11B2	6.33e-06	2	88	2	15731365
Pubmed	Salt-sensitive blood pressure in mice with increased expression of aldosterone synthase.	CYP11B1 CYP11B2	6.33e-06	2	88	2	18039983
Pubmed	Immunoreactivity of oxytocin receptor and transient receptor potential vanilloid type 1 and its correlation with dysmenorrhea in adenomyosis.	TRPV1 OXTR	6.33e-06	2	88	2	20096818
Pubmed	Cyp11b1 null mouse, a model of congenital adrenal hyperplasia.	CYP11B1 CYP11B2	6.33e-06	2	88	2	19029289
Pubmed	Genetic variation at the locus encompassing 11-beta hydroxylase and aldosterone synthase accounts for heritability in cortisol precursor (11-deoxycortisol) urinary metabolite excretion.	CYP11B1 CYP11B2	6.33e-06	2	88	2	15522937
Pubmed	[Genetic variants of CYP1B1 and WDR36 in the patients with primary congenital glaucoma and primary open angle glaucoma from Saint-Petersburg].	CYP1B1 WDR36	1.90e-05	3	88	2	20198978
Pubmed	Immune escape of colorectal tumours via local LRH-1/Cyp11b1-mediated synthesis of immunosuppressive glucocorticoids.	CYP11B1 CYP11B2	1.90e-05	3	88	2	36861295
Pubmed	Adrenal-Specific KO of the Circadian Clock Protein BMAL1 Alters Blood Pressure Rhythm and Timing of Eating Behavior.	CYP11B1 CYP11B2	1.90e-05	3	88	2	36778748
Pubmed	Neurosteroid biosynthesis: genes for adrenal steroidogenic enzymes are expressed in the brain.	CYP11B1 CYP11B2	1.90e-05	3	88	2	8111631
Pubmed	The roles of cAMP and cAMP-dependent protein kinase in the expression of cholesterol side chain cleavage and steroid 11 beta-hydroxylase genes in mouse adrenocortical tumor cells.	CYP11B1 CYP11B2	1.90e-05	3	88	2	2546938
Pubmed	Kidney function in mice lacking aldosterone.	CYP11B1 CYP11B2	1.90e-05	3	88	2	16118390
Pubmed	Myosin-XVa is required for tip localization of whirlin and differential elongation of hair-cell stereocilia.	WHRN MYO15A	1.90e-05	3	88	2	15654330
Pubmed	Interaction of CYP11B1 (cytochrome P-45011 beta) with CYP11A1 (cytochrome P-450scc) in COS-1 cells.	CYP11B1 CYP11B2	1.90e-05	3	88	2	10411633
Pubmed	Differential effects of high and low steroidogenic factor-1 expression on CYP11B2 expression and aldosterone production in adrenocortical cells.	CYP11B1 CYP11B2	1.90e-05	3	88	2	18974272
Pubmed	SUR1-TRPM4 and AQP4 form a heteromultimeric complex that amplifies ion/water osmotic coupling and drives astrocyte swelling.	ABCC8 AQP4	1.90e-05	3	88	2	28906027
Pubmed	Aldosterone-induced coronary dysfunction in transgenic mice involves the calcium-activated potassium (BKCa) channels of vascular smooth muscle cells.	CYP11B1 CYP11B2	1.90e-05	3	88	2	17984374
Pubmed	Time-Resolved Fast Mammalian Behavior Reveals the Complexity of Protective Pain Responses.	TRPV1 TAC1	1.90e-05	3	88	2	28683326
Pubmed	Different isozymes of mouse 11 beta-hydroxylase produce mineralocorticoids and glucocorticoids.	CYP11B1 CYP11B2	1.90e-05	3	88	2	1686470
Pubmed	Identification and characterization of two upstream elements that regulate adrenocortical expression of steroid 11 beta-hydroxylase.	CYP11B1 CYP11B2	1.90e-05	3	88	2	2233742
Pubmed	Substrate-induced modulation of protein-protein interactions within human mitochondrial cytochrome P450-dependent system.	CYP11B1 CYP11B2	1.90e-05	3	88	2	33271253
Pubmed	Mislocalization of protein kinase A drives pathology in Cushing's syndrome.	CYP11B1 CYP11B2	1.90e-05	3	88	2	35830806
Pubmed	The prolactin regulatory element-binding regulates of the 11beta-hydroxylase gene.	CYP11B1 CYP11B2	1.90e-05	3	88	2	18801336
Pubmed	Differential regulation of aldosterone synthase and 11beta-hydroxylase transcription by steroidogenic factor-1.	CYP11B1 CYP11B2	1.90e-05	3	88	2	11932209
Pubmed	Aldosterone postnatally, but not at birth, is required for optimal induction of renal mineralocorticoid receptor expression and sodium reabsorption.	CYP11B1 CYP11B2	1.90e-05	3	88	2	21467193
Pubmed	αCGRP is essential for algesic exocytotic mobilization of TRPV1 channels in peptidergic nociceptors.	TRPV1 TAC1	1.90e-05	3	88	2	25489075
Pubmed	Phase separation-mediated condensation of Whirlin-Myo15-Eps8 stereocilia tip complex.	WHRN MYO15A	1.90e-05	3	88	2	33626355
Pubmed	Control of renin secretion from kidneys with renin cell hyperplasia.	CYP11B1 CYP11B2	1.90e-05	3	88	2	24285498
Pubmed	Expression of the steroidogenic enzyme P450scc in the central and peripheral nervous systems during rodent embryogenesis.	CYP11B1 CYP11B2	1.90e-05	3	88	2	7750493
Pubmed	Gut-innervating nociceptors regulate the intestinal microbiota to promote tissue protection.	TRPV1 TAC1	1.90e-05	3	88	2	36240781
Pubmed	Antiaging Gene Klotho Regulates Adrenal CYP11B2 Expression and Aldosterone Synthesis.	CYP11B1 CYP11B2	1.90e-05	3	88	2	26471128
Pubmed	Molecular Recognition in Mitochondrial Cytochromes P450 That Catalyze the Terminal Steps of Corticosteroid Biosynthesis.	CYP11B1 CYP11B2	1.90e-05	3	88	2	28355486
Pubmed	Oxtr/TRPV1 expression and acclimation of skeletal muscle to cold-stress in male mice.	TRPV1 OXTR	1.90e-05	3	88	2	33705350
Pubmed	Angiotensin II induces coordinated calcium bursts in aldosterone-producing adrenal rosettes.	CYP11B1 CYP11B2	1.90e-05	3	88	2	32245948
Pubmed	Hydrogen sulfide and neurogenic inflammation in polymicrobial sepsis: involvement of substance P and ERK-NF-κB signaling.	TRPV1 TAC1	3.79e-05	4	88	2	21931742
Pubmed	Whirlin complexes with p55 at the stereocilia tip during hair cell development.	WHRN MYO15A	3.79e-05	4	88	2	16829577
Pubmed	Zona Glomerulosa-Derived Klotho Modulates Aldosterone Synthase Expression in Young Female Mice.	CYP11B1 CYP11B2	3.79e-05	4	88	2	38573585
Pubmed	Adrenal Abcg1 Controls Cholesterol Flux and Steroidogenesis.	CYP11B1 CYP11B2	3.79e-05	4	88	2	38301271
Pubmed	Crosstalk between androgen receptor and WNT/β-catenin signaling causes sex-specific adrenocortical hyperplasia in mice.	CYP11B1 CYP11B2	3.79e-05	4	88	2	37102205
Pubmed	Familial varieties of primary aldosteronism.	CYP11B1 CYP11B2	3.79e-05	4	88	2	11903322
Interaction	OPALIN interactions	PIGN ATP6V1H NF1 ATP13A1 RHOBTB3 VPS50 AGPAT3 CLN6 XPO4	2.19e-07	209	84	9	int:OPALIN
Interaction	C3orf18 interactions	NF1 ATP13A1 INTS4 XPO4 TTI1 ARMH3	8.57e-06	115	84	6	int:C3orf18
Interaction	LRRC25 interactions	ATP6V1H NF1 ATP13A1 RHOBTB3 VPS50 CLN6 INTS4	1.22e-05	185	84	7	int:LRRC25
Interaction	TPST2 interactions	NF1 IPO7 SLC39A9 ATP13A1 XPO4 TMCO3	1.32e-05	124	84	6	int:TPST2
Interaction	FPR2 interactions	PIGN VPS50 TTI1 TMCO3 RFT1 ATP9A	2.42e-05	138	84	6	int:FPR2
Interaction	KIR2DL4 interactions	IPO7 ATP13A1 RHOBTB3 INTS4 XPO4	4.58e-05	94	84	5	int:KIR2DL4
Interaction	P2RY2 interactions	XPO4 SLC39A6 RFT1 ATP9A FAM8A1	1.05e-04	112	84	5	int:P2RY2
Interaction	SIGLECL1 interactions	NF1 IPO7 INTS4 XPO4 TTI1	1.10e-04	113	84	5	int:SIGLECL1
Interaction	NIPAL1 interactions	ATP13A1 AGPAT3 TMCO3 RFT1 ATP9A	1.15e-04	114	84	5	int:NIPAL1
GeneFamily	Trace amine receptors	TAAR3P TAAR9 TAAR8	3.50e-06	9	64	3	188
GeneFamily	Cytochrome P450 family 11	CYP11B1 CYP11B2	3.69e-05	3	64	2	1007
GeneFamily	Doublecortin superfamily	DCDC1 RP1L1	5.45e-04	10	64	2	1369
GeneFamily	BPI fold containing	BPIFB1 BPIFB6	1.43e-03	16	64	2	456
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Crispld2_Htr2c\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	CYP1B1 OXTR KCNF1 TAC1 PCDH18 TNS3	9.39e-07	165	88	6	c6b23013d77fa9aa967b76e451c8e42b0a657c30
Drug	Tetrahydronaphthalenes	TRPV1 CYP11B1 CYP11B2	1.07e-06	6	87	3	ctd:D013764
Drug	Indans	TRPV1 CYP11B1 CYP11B2	6.34e-06	10	87	3	ctd:D007189
Drug	2,3,3',4,4',5-hexachlorobiphenyl	CYP1B1 CYP11B1 CYP11B2	8.70e-06	11	87	3	ctd:C087667
Drug	cyadox	CYP11B1 CYP11B2	1.44e-05	2	87	2	ctd:C020728
Drug	olvanil	TRPV1 TAC1	1.44e-05	2	87	2	ctd:C054256
Drug	18-hydroxydeoxycorticosterone	CYP11B1 CYP11B2	1.44e-05	2	87	2	ctd:C042509
Drug	3,4,5,3',4',5'-hexachlorobiphenyl	CYP1B1 CYP11B1 CYP11B2	1.50e-05	13	87	3	ctd:C027309
Drug	3',4'-dimethoxyflavone	CYP1B1 CYP11B1 CYP11B2	2.91e-05	16	87	3	ctd:C509288
Drug	tetrahydrocortisol	CYP1B1 WDR36 CYP11B1 CYP11B2	3.40e-05	48	87	4	CID000005864
Drug	GR 73632	TRPV1 TAC1	4.32e-05	3	87	2	ctd:C068032
Drug	18-hydroxycortisol	CYP11B1 CYP11B2	4.32e-05	3	87	2	ctd:C033689
Disease	adrenal cortical adenoma (is_marker_for)	CYP11B1 CYP11B2	8.40e-06	2	86	2	DOID:0050891 (is_marker_for)
Disease	Glucocorticoid-remediable aldosteronism	CYP11B1 CYP11B2	8.40e-06	2	86	2	C1260386
Disease	congenital adrenal hyperplasia (implicated_via_orthology)	CYP11B1 CYP11B2	2.51e-05	3	86	2	DOID:0050811 (implicated_via_orthology)
Disease	Disorder of eye	WHRN CYP1B1 EYS CLN6 OAT WDPCP	3.73e-05	212	86	6	C0015397
Disease	carbohydrate sulfotransferase 15 measurement	FPR3 OAT	8.35e-05	5	86	2	EFO_0008066
Disease	primary hyperaldosteronism (is_implicated_in)	CYP11B1 CYP11B2	8.35e-05	5	86	2	DOID:446 (is_implicated_in)
Disease	Conn Syndrome	CYP11B1 CYP11B2	1.25e-04	6	86	2	C1384514
Disease	Hyperaldosteronism	CYP11B1 CYP11B2	1.25e-04	6	86	2	C0020428
Disease	protocadherin alpha-7 measurement	CYP11B1 CYP11B2	1.75e-04	7	86	2	EFO_0801973
Disease	protein FAM163B measurement	CYP11B1 CYP11B2	2.98e-04	9	86	2	EFO_0802936
Disease	androstenedione measurement	CYP11B1 CYP11B2	3.72e-04	10	86	2	EFO_0007972
Disease	3-hydroxyanthranilate 3,4-dioxygenase measurement	CYP11B1 CYP11B2	4.54e-04	11	86	2	EFO_0021862
Disease	coagulation factor XA measurement	WHRN PCID2	4.54e-04	11	86	2	EFO_0020266
Disease	cell growth regulator with EF hand domain protein 1 measurement	CYP11B1 CYP11B2	4.54e-04	11	86	2	EFO_0801461
Disease	Inflammation	TRPV1 CLN6 TAC1 KYNU	5.29e-04	127	86	4	C0021368
Disease	myocardial infarction (implicated_via_orthology)	CYP1B1 TRPV1 CYP11B1	9.58e-04	66	86	3	DOID:5844 (implicated_via_orthology)
Disease	neutrophil collagenase measurement	ABCA13 CYP11B1	9.81e-04	16	86	2	EFO_0008248
Disease	protein Z-dependent protease inhibitor measurement	SERPINA9 PCID2	1.25e-03	18	86	2	EFO_0021849
Disease	Pheochromocytoma	NF1 SDHC	1.39e-03	19	86	2	C0031511
Disease	Hereditary Paraganglioma-Pheochromocytoma Syndrome	NF1 SDHC	2.04e-03	23	86	2	C1708353
Disease	primary open angle glaucoma (is_implicated_in)	CYP1B1 WDR36	2.04e-03	23	86	2	DOID:1070 (is_implicated_in)
Disease	neutrophil count	IPO7 SLC39A9 ATP13A1 TMEM87B RP1L1 TBC1D12 NLRC5 TMCO3 PREX2 SDHC TNS3	2.23e-03	1382	86	11	EFO_0004833
Disease	apolipoprotein L1 measurement	CYP11B1 CYP11B2	2.41e-03	25	86	2	EFO_0021854

Protein segments in the cluster

Peptide	Gene	Start	Entry
LLQMDFIHIAQFLTK	TBC1D12	711	O60347
KAVTAEFLAMLIFVL	AQP4	36	P55087
HKLSFLVNALAKQVM	BPIFB1	171	Q8TDL5
HMFIKNSLISILGLA	ADAM21	296	Q9UKJ8
LTVMLQFFVHFLSLV	ATP13A1	1056	Q9HD20
FFILLFGTIMDHKIR	ADGRF4	646	Q8IZF3
SMALQKITLQFAHFL	ABCA13	2091	Q86UQ4
AKHNIFTLALMIVNL	ARMH3	516	Q5T2E6
IKISHFLKMESLNFI	MS4A1	141	P11836
HFTLSMEVFLQQLRK	DMXL1	401	Q9Y485
MKHLVASSILGVFVL	GKN3P	1	P0CG01
VHMYLLIFLKFVQAV	ATG3	286	Q9NT62
NVLQAFVKMLLSVSH	RANBP17	861	Q9H2T7
VLAQAHMFVKLKVIA	RFT1	141	Q96AA3
VKILQTMLRQSAFLH	INTS4	796	Q96HW7
AKMHFRFVFALLIVS	PCDH18	6	Q9HCL0
MKNIKALVAFHSTAL	DCDC1	1266	M0R2J8
QVALSRKMAELVHFL	MAGEA12	106	P43365
IVILSLMVFHSSFIN	EYS	6	Q5T1H1
LVLQVFKTFDHMARQ	NUDCD3	61	Q8IVD9
AFIHKQAVLLAREMT	MYO15A	2456	Q9UKN7
LLNHLVFVQKVFMKE	KIAA1109	3106	Q2LD37
LNVFITMAKVFLILH	FPR3	191	P25089
TMAKVFLILHFIIGF	FPR3	196	P25089
HFKLVVLFSQMRLAN	CCDC178	811	Q5BJE1
LMTLVSFKQNEFLHL	FSIP2	831	Q5CZC0
VAAMQHFLPVLKDRF	IPO7	171	O95373
MHSFAQILLIFHLLF	OR4X2	146	Q8NGF9
FSITQFKHLGRLLMV	ATP9A	816	O75110
FFMKHLSIADLVVAV	OXTR	76	P30559
MQHSLVFFFAVILHL	PRNT	1	Q86SH4
SKNHLVVLAIAFFMV	GPR3	191	P46089
LHISLQHKTVIFMFA	NLRC5	931	Q86WI3
HQLSLDAFLVALKFM	PCID2	336	Q5JVF3
FISMSAIVNHLLRQK	WDPCP	521	O95876
TIHKELAMFVQLLRA	GCNT7	116	Q6ZNI0
SVLLLKVHGALMFVA	FRRS1	366	Q6ZNA5
ALIHTAKFALVFPLM	SDHC	111	Q99643
FLPAFVRMKQLISEH	GFOD2	126	Q3B7J2
LNFLHALEVMFKSTV	CYP11B1	221	P15538
MSLFLLEVHFNLKVQ	BPIFB6	351	Q8NFQ5
VFIFHMLKLAVNVPL	CAPRIN2	1046	Q6IMN6
LKLRMAQHLQAAVAF	IMP3	116	Q9NV31
SKMQLFLFISILAHQ	CYP1B1	476	Q16678
LNFLHALEVMFKSTV	CYP11B2	221	P19099
LIVFVAIMLHKAPAA	SLC39A9	176	Q9NUM3
FFIKATIVLSIMHLS	FAM8A1	261	Q9UBU6
MIIKHFFGTVLVLLA	IFNE	1	Q86WN2
HFLELMAFFLAVVTL	OR6C75	191	A6NL08
KIVLCAVSHVFMLLF	RHOBTB3	271	O94955
FLIMHKITNCILFFG	SERPINB2	396	P05120
LFGNLVIMVSISHFK	TAAR3P	46	Q9P1P4
MVTFLQGELHVSKLF	STRADA	111	Q7RTN6
FTVHMAARIIAKLAA	ATP6V1H	136	Q9UI12
FLTLSVVVMKFLLAA	TMCO3	581	Q6UWJ1
VFGNLLVMTSVLHFK	TAAR8	46	Q969N4
LLVMIAILHFKQLHT	TAAR9	51	Q96RI9
VAAQKFSLAHSMLAI	TSC22D4	286	Q9Y3Q8
KLNHVILAMVSVFLV	MRGPRF	236	Q96AM1
ITMFFLLHFIVLINV	RXFP2	16	Q8WXD0
VEALVMALFKLLNTH	WHRN	456	Q9P202
VKMNASPLFLHFVIL	TNS3	171	Q68CZ2
RVIHAFNMNKIISIF	OR6B1	261	O95007
MFSKLAHLQRFAVLS	OAT	1	P04181
LLTAMVLVNHIFFKA	SERPINA9	196	Q86WD7
FGIMLLISIFEHKIV	SLC39A6	736	Q13433
VFSQLLKHMVLVAID	ABCC8	1016	Q09428
HFTKIQIMKLIINFT	ARMCX1	341	Q9P291
FTFFAMLALVLHQKR	CLN6	236	Q9NWW5
LFLVSQMAILALFFH	CHST4	11	Q8NCG5
NILKPIAFDVIHFMS	VPS50	626	Q96JG6
LFLATRHFLKLVFDM	XPO4	1046	Q9C0E2
MGLLAFLKTQFVLHL	AGPAT3	1	Q9NRZ7
LAVHQRAFKTFSALM	RP1L1	51	Q8IWN7
LFMLATVVLYFSHLK	TRPV1	521	Q8NER1
ARKILHELIFSSFFM	UBR1	366	Q8IWV7
LMSKILQSIANHVLF	NF1	1441	P21359
FKIHPVLFAQALESM	PREX2	1401	Q70Z35
VISDIMALHFFFLVK	PIGN	866	O95427
KNTLIFAVLASIVFM	TMEM87B	396	Q96K49
KAFSQFSMLIIHVRI	ZNF569	361	Q5MCW4
LERVKNSMLSVLFHF	UGT2A3	206	Q6UWM9
NMIFHAVVSVIFLKV	TMTC3	96	Q6ZXV5
MKILVALAVFFLVST	TAC1	1	P20366
TLKIHLFSMAFRELQ	UNC13D	516	Q70J99
VKLQEAARSVFLHLM	TTI1	1021	O43156
RAAMVSKFFLSHLVL	PLPP7	196	Q8NBV4
VIIHNIKFNETLMKF	WDR36	271	Q8NI36
LFKLFHVCLFTINNM	PP6455	101	Q8WZ26
NKLHFALSFMNIVDV	KCNF1	246	Q9H3M0
ALTVNLHLLMLSFFK	KYNU	136	Q16719