Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	FZD1 OR6F1 XCR1 FZD5 GPR42 FFAR2 OR6Q1 GPR182 PKD1 GRID1 CCR4 TAS2R60 GABBR2 GPR176 LEPR OR6X1 OR2AG1	9.42e-08	1353	56	17	GO:0004888
GeneOntologyMolecularFunction	G protein-coupled receptor activity	FZD1 OR6F1 XCR1 FZD5 GPR42 FFAR2 OR6Q1 GPR182 CCR4 TAS2R60 GABBR2 GPR176 OR6X1 OR2AG1	1.03e-07	884	56	14	GO:0004930
GeneOntologyMolecularFunction	Wnt receptor activity	FZD1 FZD5 PKD1	1.38e-05	17	56	3	GO:0042813
GeneOntologyBiologicalProcess	G protein-coupled receptor signaling pathway	FZD1 OR6F1 XCR1 FZD5 GPR42 FFAR2 OR6Q1 GPR182 CCR4 TAS2R60 GABBR2 GPR176 OR6X1 OR2AG1	1.54e-05	1395	56	14	GO:0007186
GeneOntologyBiologicalProcess	positive regulation of acute inflammatory response to non-antigenic stimulus	GPR42 FFAR2	2.17e-05	3	56	2	GO:0002879
GeneOntologyBiologicalProcess	regulation of acute inflammatory response to non-antigenic stimulus	GPR42 FFAR2	4.33e-05	4	56	2	GO:0002877
GeneOntologyBiologicalProcess	detection of mechanical stimulus	PKD1 STRC PKDREJ STRCP1	5.13e-05	75	56	4	GO:0050982
GeneOntologyBiologicalProcess	acute inflammatory response to non-antigenic stimulus	GPR42 FFAR2	7.20e-05	5	56	2	GO:0002525
GeneOntologyBiologicalProcess	detection of stimulus	OR6F1 OR6Q1 PKD1 STRC TAS2R60 PKDREJ OR6X1 STRCP1 OR2AG1	1.30e-04	722	56	9	GO:0051606
Domain	7tm_1	OR6F1 XCR1 GPR42 FFAR2 OR6Q1 GPR182 CCR4 GPR176 OR6X1 OR2AG1	2.07e-05	677	54	10	PF00001
Domain	G_PROTEIN_RECEP_F1_1	OR6F1 XCR1 GPR42 FFAR2 OR6Q1 GPR182 CCR4 GPR176 OR6X1 OR2AG1	2.29e-05	685	54	10	PS00237
Domain	G_PROTEIN_RECEP_F1_2	OR6F1 XCR1 GPR42 FFAR2 OR6Q1 GPR182 CCR4 GPR176 OR6X1 OR2AG1	2.47e-05	691	54	10	PS50262
Domain	GPCR_Rhodpsn	OR6F1 XCR1 GPR42 FFAR2 OR6Q1 GPR182 CCR4 GPR176 OR6X1 OR2AG1	2.50e-05	692	54	10	IPR000276
Domain	GPR40-rel_orph	GPR42 FFAR2	4.90e-05	4	54	2	IPR013312
Domain	REJ	PKD1 PKDREJ	4.90e-05	4	54	2	PS51111
Domain	REJ_dom	PKD1 PKDREJ	4.90e-05	4	54	2	IPR014010
Domain	GPCR_Rhodpsn_7TM	OR6F1 XCR1 FFAR2 OR6Q1 GPR182 CCR4 GPR176 OR6X1 OR2AG1	1.17e-04	670	54	9	IPR017452
Domain	PKD/REJ-like	PKD1 PKDREJ	1.22e-04	6	54	2	IPR002859
Domain	REJ	PKD1 PKDREJ	1.22e-04	6	54	2	PF02010
Domain	Frizzled	FZD1 FZD5	4.44e-04	11	54	2	IPR000539
Domain	Frizzled	FZD1 FZD5	4.44e-04	11	54	2	PF01534
Domain	PKD_channel	PKD1 PKDREJ	4.44e-04	11	54	2	PF08016
Domain	PKD1_2_channel	PKD1 PKDREJ	4.44e-04	11	54	2	IPR013122
Domain	Frizzled	FZD1 FZD5	4.44e-04	11	54	2	SM01330
Domain	Frizzled/SFRP	FZD1 FZD5	9.59e-04	16	54	2	IPR015526
Domain	LH2	PKD1 PKDREJ	1.22e-03	18	54	2	SM00308
Domain	FRI	FZD1 FZD5	1.51e-03	20	54	2	SM00063
Domain	PLAT	PKD1 PKDREJ	1.66e-03	21	54	2	PS50095
Domain	-	PKD1 PKDREJ	1.66e-03	21	54	2	2.60.60.20
Domain	-	FZD1 FZD5	1.66e-03	21	54	2	1.10.2000.10
Domain	PLAT	PKD1 PKDREJ	1.66e-03	21	54	2	PF01477
Domain	PLAT/LH2_dom	PKD1 PKDREJ	1.66e-03	21	54	2	IPR001024
Domain	Claudin_CS	CLDN20 CLDN19	1.83e-03	22	54	2	IPR017974
Domain	CLAUDIN	CLDN20 CLDN19	1.83e-03	22	54	2	PS01346
Domain	Frizzled_dom	FZD1 FZD5	2.17e-03	24	54	2	IPR020067
Domain	FZ	FZD1 FZD5	2.17e-03	24	54	2	PS50038
Domain	Fz	FZD1 FZD5	2.17e-03	24	54	2	PF01392
Domain	Claudin	CLDN20 CLDN19	2.96e-03	28	54	2	IPR006187
Domain	GPS	PKD1 PKDREJ	4.34e-03	34	54	2	SM00303
Domain	GPS	PKD1 PKDREJ	5.12e-03	37	54	2	IPR000203
Domain	ANF_lig-bd_rcpt	GRID1 GABBR2	5.12e-03	37	54	2	IPR001828
Domain	ANF_receptor	GRID1 GABBR2	5.12e-03	37	54	2	PF01094
Domain	cNMP-bd-like	POPDC2 CNGA2	5.40e-03	38	54	2	IPR018490
Domain	Peripla_BP_I	GRID1 GABBR2	5.68e-03	39	54	2	IPR028082
Domain	PMP22_Claudin	CLDN20 CLDN19	5.97e-03	40	54	2	PF00822
Domain	PMP22/EMP/MP20/Claudin	CLDN20 CLDN19	7.50e-03	45	54	2	IPR004031
Domain	RmlC-like_jellyroll	POPDC2 CNGA2	9.56e-03	51	54	2	IPR014710
Pathway	WP_GPCRS_NONODORANT	FZD1 XCR1 FZD5 GPR42 FFAR2 CCR4 GABBR2	1.93e-05	266	45	7	MM15843
Pathway	KEGG_CELL_ADHESION_MOLECULES_CAMS	NEGR1 CLDN20 SIGLEC1 CLDN19 CNTN1	6.26e-05	133	45	5	M16476
Pathway	WP_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_IN_COLORECTAL_CANCER	FZD1 FZD5 PKD1 CLDN20 CLDN19	1.54e-04	161	45	5	M39770
Pubmed	Destabilization of β Cell FIT2 by saturated fatty acids alter lipid droplet numbers and contribute to ER stress and diabetes.	FITM2 LEPR	2.64e-06	2	57	2	35254894
Pubmed	Mutations in a new gene encoding a protein of the hair bundle cause non-syndromic deafness at the DFNB16 locus.	STRC STRCP1	2.64e-06	2	57	2	11687802
Pubmed	Dual-vector gene therapy restores cochlear amplification and auditory sensitivity in a mouse model of DFNB16 hearing loss.	STRC STRCP1	2.64e-06	2	57	2	34910522
Pubmed	Cochlear outer hair cell horizontal top connectors mediate mature stereocilia bundle mechanics.	STRC STRCP1	7.91e-06	3	57	2	30801007
Pubmed	The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids.	GPR42 FFAR2	7.91e-06	3	57	2	12496283
Pubmed	Short-chain fatty acids activate GPR41 and GPR43 on intestinal epithelial cells to promote inflammatory responses in mice.	GPR42 FFAR2	7.91e-06	3	57	2	23665276
Pubmed	Microbial short-chain fatty acids modulate CD8+ T cell responses and improve adoptive immunotherapy for cancer.	GPR42 FFAR2	7.91e-06	3	57	2	34210970
Pubmed	Dietary short-chain fatty acid intake improves the hepatic metabolic condition via FFAR3.	GPR42 FFAR2	7.91e-06	3	57	2	31719611
Pubmed	Acetate and propionate short chain fatty acids stimulate adipogenesis via GPCR43.	GPR42 FFAR2	7.91e-06	3	57	2	16123168
Pubmed	Wingless-type MMTV integration site family member 5a is a key inhibitor of islet stellate cells activation.	FZD5 LEPR	7.91e-06	3	57	2	31368666
Pubmed	Extracellular ionic locks determine variation in constitutive activity and ligand potency between species orthologs of the free fatty acid receptors FFA2 and FFA3.	GPR42 FFAR2	7.91e-06	3	57	2	23066016
Pubmed	Loss of FFA2 and FFA3 increases insulin secretion and improves glucose tolerance in type 2 diabetes.	GPR42 FFAR2	7.91e-06	3	57	2	25581519
Pubmed	Short-chain fatty acids stimulate glucagon-like peptide-1 secretion via the G-protein-coupled receptor FFAR2.	GPR42 FFAR2	7.91e-06	3	57	2	22190648
Pubmed	Microbiota-Derived Short-Chain Fatty Acids Promote the Memory Potential of Antigen-Activated CD8+ T Cells.	GPR42 FFAR2	7.91e-06	3	57	2	31272808
Pubmed	GPR41/FFAR3 and GPR43/FFAR2 as cosensors for short-chain fatty acids in enteroendocrine cells vs FFAR3 in enteric neurons and FFAR2 in enteric leukocytes.	GPR42 FFAR2	7.91e-06	3	57	2	23885020
Pubmed	Dietary Fiber Confers Protection against Flu by Shaping Ly6c- Patrolling Monocyte Hematopoiesis and CD8+ T Cell Metabolism.	GPR42 FFAR2	7.91e-06	3	57	2	29768180
Pubmed	GPR41 and GPR43 regulate CD8+ T cell priming during herpes simplex virus type 1 infection.	GPR42 FFAR2	7.91e-06	3	57	2	38524121
Pubmed	Abnormalities in microbiota/butyrate/FFAR3 signaling in aging gut impair brain function.	GPR42 FFAR2	7.91e-06	3	57	2	38329121
Pubmed	Stereocilin-deficient mice reveal the origin of cochlear waveform distortions.	STRC STRCP1	1.58e-05	4	57	2	18849963
Pubmed	A cluster of four novel human G protein-coupled receptor genes occurring in close proximity to CD22 gene on chromosome 19q13.1.	GPR42 FFAR2	1.58e-05	4	57	2	9344866
Pubmed	Short-chain fatty acids and ketones directly regulate sympathetic nervous system via G protein-coupled receptor 41 (GPR41).	GPR42 FFAR2	1.58e-05	4	57	2	21518883
Pubmed	A family of fatty acid binding receptors.	GPR42 FFAR2	1.58e-05	4	57	2	15684720
Pubmed	Copy Number Variations in Candidate Genes and Intergenic Regions Affect Body Mass Index and Abdominal Obesity in Mexican Children.	NEGR1 LEPR	1.58e-05	4	57	2	28428959
Pubmed	XCR1+ type 1 conventional dendritic cells drive liver pathology in non-alcoholic steatohepatitis.	XCR1 LEPR	1.58e-05	4	57	2	34017133
Pubmed	Microbial metabolites, short-chain fatty acids, restrain tissue bacterial load, chronic inflammation, and associated cancer in the colon of mice.	GPR42 FFAR2	1.58e-05	4	57	2	29644622
Pubmed	Polycystin channels and kidney disease.	PKD1 PKDREJ	2.63e-05	5	57	2	11698076
Pubmed	Non-association between polymorphisms of the frizzled receptor genes and bone mineral density in postmenopausal Korean women.	FZD1 FZD5	2.63e-05	5	57	2	19543507
Pubmed	Fatty acid binding receptors and their physiological role in type 2 diabetes.	GPR42 FFAR2	2.63e-05	5	57	2	19009545
Pubmed	Seven transmembrane G protein-coupled receptor repertoire of gastric ghrelin cells.	GPR42 FFAR2	2.63e-05	5	57	2	24327954
Pubmed	An unusually powerful mode of low-frequency sound interference due to defective hair bundles of the auditory outer hair cells.	STRC STRCP1	2.63e-05	5	57	2	24920589
Pubmed	Free fatty acid receptors act as nutrient sensors to regulate energy homeostasis.	GPR42 FFAR2	3.94e-05	6	57	2	19460454
Pubmed	Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R).	FZD1 FZD5	5.51e-05	7	57	2	15370539
Pubmed	Vagal neuron expression of the microbiota-derived metabolite receptor, free fatty acid receptor (FFAR3), is necessary for normal feeding behavior.	GPR42 FFAR2	7.34e-05	8	57	2	34626852
Pubmed	Dysfunction of Wnt signaling and synaptic disassembly in neurodegenerative diseases.	FZD1 FZD5	7.34e-05	8	57	2	24449494
Pubmed	ATG101 Degradation by HUWE1-Mediated Ubiquitination Impairs Autophagy and Reduces Survival in Cancer Cells.	MID1 HUWE1	7.34e-05	8	57	2	34502089
Pubmed	Stereocilin connects outer hair cell stereocilia to one another and to the tectorial membrane.	STRC STRCP1	7.34e-05	8	57	2	21165971
Pubmed	Differential expression of the Wnt putative receptors Frizzled during mouse somitogenesis.	FZD1 FZD5	7.34e-05	8	57	2	10559494
Pubmed	A coated vesicle-associated kinase of 104 kDa (CVAK104) induces lysosomal degradation of frizzled 5 (Fzd5).	FZD1 FZD5	7.34e-05	8	57	2	19643732
Pubmed	Genetic predictors of glucocorticoid-induced hypertension in children with acute lymphoblastic leukemia.	SLC12A3 LEPR	7.34e-05	8	57	2	18496130
Pubmed	A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals.	FZD1 FZD5	9.43e-05	9	57	2	9707618
Pubmed	Two members of the TRPP family of ion channels, Pkd1l3 and Pkd2l1, are co-expressed in a subset of taste receptor cells.	PKD1 PKDREJ	1.18e-04	10	57	2	16805797
Pubmed	Expression of Frizzled genes in developing and postnatal hair follicles.	FZD1 FZD5	1.18e-04	10	57	2	15245425
Pubmed	Essential roles of mesenchyme-derived beta-catenin in mouse Müllerian duct morphogenesis.	FZD1 FZD5	1.18e-04	10	57	2	17532316
Pubmed	Frizzled-9 impairs acetylcholine receptor clustering in skeletal muscle cells.	FZD1 FZD5	1.44e-04	11	57	2	24860427
Pubmed	Clarin-2 is essential for hearing by maintaining stereocilia integrity and function.	STRC STRCP1	1.44e-04	11	57	2	31448880
Pubmed	Molecular determinants of WNT9b responsiveness in nephron progenitor cells.	FZD1 FZD5	1.44e-04	11	57	2	30978219
Pubmed	Distinct but redundant expression of the Frizzled Wnt receptor genes at signaling centers of the developing mouse brain.	FZD1 FZD5	1.44e-04	11	57	2	17582687
Pubmed	Otogelin, otogelin-like, and stereocilin form links connecting outer hair cell stereocilia to each other and the tectorial membrane.	STRC STRCP1	1.44e-04	11	57	2	31776257
Pubmed	Expression of Frizzled5, Frizzled7, and Frizzled10 during early mouse development and interactions with canonical Wnt signaling.	FZD1 FZD5	1.44e-04	11	57	2	17576136
Pubmed	Microbiota modulate sympathetic neurons via a gut-brain circuit.	GPR42 FFAR2	2.73e-04	15	57	2	32641826
Pubmed	Genome-wide association study identifies new susceptibility loci for posttraumatic stress disorder.	GRID1 GABBR2	3.12e-04	16	57	2	23726511
Pubmed	Mapping of Wnt-Frizzled interactions by multiplex CRISPR targeting of receptor gene families.	FZD1 FZD5	3.53e-04	17	57	2	28733458
Pubmed	Mammalian Otolin: a multimeric glycoprotein specific to the inner ear that interacts with otoconial matrix protein Otoconin-90 and Cerebellin-1.	STRC STRCP1	3.53e-04	17	57	2	20856818
Pubmed	Genome-wide SNP and CNV analysis identifies common and low-frequency variants associated with severe early-onset obesity.	NEGR1 LEPR	4.43e-04	19	57	2	23563609
Pubmed	The FERM protein Epb4.1l5 is required for organization of the neural plate and for the epithelial-mesenchymal transition at the primitive streak of the mouse embryo.	MYO10 CRB2	4.43e-04	19	57	2	17507402
Pubmed	Biology of claudins.	CLDN20 CLDN19	4.43e-04	19	57	2	18480174
Pubmed	Regulation of angiogenesis by a non-canonical Wnt-Flt1 pathway in myeloid cells.	FZD1 FZD5	4.43e-04	19	57	2	21623369
Pubmed	Multifunctional strands in tight junctions.	CLDN20 CLDN19	5.43e-04	21	57	2	11283726
Pubmed	Claudin-based barrier in simple and stratified cellular sheets.	CLDN20 CLDN19	5.43e-04	21	57	2	12231346
Pubmed	Tight junction proteins.	CLDN20 CLDN19	5.43e-04	21	57	2	12475568
Pubmed	Tight junctions of the blood-brain barrier.	CLDN20 CLDN19	5.43e-04	21	57	2	10690502
Pubmed	The roles of claudin superfamily proteins in paracellular transport.	CLDN20 CLDN19	5.43e-04	21	57	2	11247307
Pubmed	Expression of the Wnt inhibitor Dickkopf-1 is required for the induction of neural markers in mouse embryonic stem cells differentiating in response to retinoic acid.	FZD1 FZD5	5.97e-04	22	57	2	17064353
Pubmed	Structure and function of claudins.	CLDN20 CLDN19	6.53e-04	23	57	2	18036336
Pubmed	The claudins.	CLDN20 CLDN19	6.53e-04	23	57	2	19706201
Pubmed	A role for Wnt/beta-catenin signaling in lens epithelial differentiation.	FZD1 FZD5	7.73e-04	25	57	2	12812787
Pubmed	Dynamic distribution of claudin proteins in pancreatic epithelia undergoing morphogenesis or neoplastic transformation.	CLDN20 CLDN19	8.36e-04	26	57	2	22275141
Pubmed	Systematic protein-protein interaction mapping for clinically relevant human GPCRs.	TRAM1L1 GPR182 PKD1 CCR4 GABBR2 CNTN1	9.66e-04	697	57	6	28298427
Pubmed	3D representation of Wnt and Frizzled gene expression patterns in the mouse embryo at embryonic day 11.5 (Ts19).	FZD1 FZD5	1.04e-03	29	57	2	18364260
Pubmed	Follow-up association studies of chromosome region 9q and nonsyndromic cleft lip/palate.	GABBR2 CRB2	1.11e-03	30	57	2	20583170
Pubmed	Differential impact of Lhx2 deficiency on expression of class I and class II odorant receptor genes in mouse.	CNGA2 OR2AG1	1.35e-03	33	57	2	17350283
Pubmed	A quantitative analysis of the spatiotemporal pattern of transient receptor potential gene expression in the developing mouse cochlea.	PKD1 PKDREJ	1.35e-03	33	57	2	19834762
Pubmed	The core SWI/SNF catalytic subunit Brg1 regulates nephron progenitor cell proliferation and differentiation.	SLC12A3 COX7B	1.52e-03	35	57	2	32504627
Pubmed	A probabilistic classifier for olfactory receptor pseudogenes.	OR6Q1 OR2AG1	1.52e-03	35	57	2	16939646
Pubmed	Hnf1b haploinsufficiency differentially affects developmental target genes in a new renal cysts and diabetes mouse model.	SLC12A3 PKD1	1.60e-03	36	57	2	33737325
Pubmed	Wnt/Rspondin/β-catenin signals control axonal sorting and lineage progression in Schwann cell development.	FZD1 FZD5	1.60e-03	36	57	2	24151333
Cytoband	19q13.1	GPR42 FFAR2 CATSPERG	4.55e-05	55	57	3	19q13.1
Cytoband	15q15.3	STRC STRCP1	4.46e-04	25	57	2	15q15.3
Cytoband	Ensembl 112 genes in cytogenetic band chr15q15	STRC GPR176 STRCP1	8.29e-04	147	57	3	chr15q15
Cytoband	Ensembl 112 genes in cytogenetic band chr1p31	NEGR1 EFCAB7 LEPR	2.76e-03	224	57	3	chr1p31
GeneFamily	Olfactory receptors, family 6	OR6F1 OR6Q1 OR6X1	2.95e-04	51	46	3	153
GeneFamily	G protein-coupled receptors, Class F frizzled	FZD1 FZD5	3.43e-04	11	46	2	286
GeneFamily	G protein-coupled receptors, Class A orphans	GPR42 GPR182 GPR176	1.03e-03	78	46	3	262
GeneFamily	Claudins	CLDN20 CLDN19	1.55e-03	23	46	2	488
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	NEGR1 SIGLEC1 CNTN1	7.95e-03	161	46	3	593
CoexpressionAtlas	DevelopingKidney_e15.5_Ureteral Smooth Musc_emap-28812_k-means-cluster#3_top-relative-expression-ranked_500	FZD1 B3GALT1 NEGR1 LEPR CNTN1	3.37e-07	63	49	5	gudmap_developingKidney_e15.5_Ureteral Smooth Musc_500_k3
CoexpressionAtlas	DevelopingKidney_e15.5_Podocyte cells_emap-27915_k-means-cluster#2_top-relative-expression-ranked_200	B3GALT1 NEGR1 LEPR CNTN1	1.24e-06	35	49	4	gudmap_developingKidney_e15.5_Podocyte cells_200_k2
CoexpressionAtlas	DevelopingKidney_e15.5_Podocyte cells_emap-27915_k-means-cluster#3_top-relative-expression-ranked_100	NEGR1 LEPR CNTN1	9.20e-06	18	49	3	gudmap_developingKidney_e15.5_Podocyte cells_100_k3
CoexpressionAtlas	DevelopingKidney_e15.5_Ureteral Smooth Musc_emap-28812_k-means-cluster#1_top-relative-expression-ranked_200	NEGR1 LEPR CNTN1	2.26e-05	24	49	3	gudmap_developingKidney_e15.5_Ureteral Smooth Musc_200_k1
CoexpressionAtlas	DevelopingKidney_e15.5_Podocyte cells_emap-27915_k-means-cluster#3_top-relative-expression-ranked_1000	FZD1 B3GALT1 NEGR1 LEPR CNTN1	3.33e-05	160	49	5	gudmap_developingKidney_e15.5_Podocyte cells_1000_k3
CoexpressionAtlas	DevelopingKidney_e15.5_Pelvic Mesenchyme_emap-8241_k-means-cluster#1_top-relative-expression-ranked_200	B3GALT1 NEGR1 LEPR CNTN1	4.62e-05	86	49	4	gudmap_developingKidney_e15.5_Pelvic Mesenchyme_200_k1
CoexpressionAtlas	DevelopingKidney_e15.5_Podocyte cells_emap-27915_k-means-cluster#5_top-relative-expression-ranked_500	B3GALT1 NEGR1 LEPR CNTN1	4.62e-05	86	49	4	gudmap_developingKidney_e15.5_Podocyte cells_500_k5
CoexpressionAtlas	DevelopingKidney_e15.5_Pelvic Mesenchyme_emap-8241_k-means-cluster#4_top-relative-expression-ranked_500	FZD1 B3GALT1 NEGR1 LEPR CNTN1	8.52e-05	195	49	5	gudmap_developingKidney_e15.5_Pelvic Mesenchyme_500_k4
CoexpressionAtlas	DevelopingKidney_e15.5_Ureteral Smooth Musc_emap-28812_k-means-cluster#4_top-relative-expression-ranked_1000	FZD1 B3GALT1 NEGR1 LEPR CNTN1	8.52e-05	195	49	5	gudmap_developingKidney_e15.5_Ureteral Smooth Musc_1000_k4
CoexpressionAtlas	DevelopingKidney_e15.5_Pelvic Mesenchyme_emap-8241_k-means-cluster#5_top-relative-expression-ranked_100	NEGR1 LEPR CNTN1	1.63e-04	46	49	3	gudmap_developingKidney_e15.5_Pelvic Mesenchyme_100_k5
CoexpressionAtlas	DevelopingKidney_e15.5_Ureteral Smooth Musc_emap-28812_top-relative-expression-ranked_500	FZD1 SFMBT1 B3GALT1 NEGR1 LEPR CNTN1	2.76e-04	393	49	6	gudmap_developingKidney_e15.5_Ureteral Smooth Musc_500
CoexpressionAtlas	DevelopingKidney_e13.5_podocyte cells_emap-27773_k-means-cluster#1_top-relative-expression-ranked_500	B3GALT1 NEGR1 LEPR CNTN1	3.22e-04	142	49	4	gudmap_developingKidney_e13.5_podocyte cells_500_k1
CoexpressionAtlas	DevelopingKidney_e15.5_Pelvic Mesenchyme_emap-8241_top-relative-expression-ranked_500	FZD1 B3GALT1 NEGR1 FHOD1 LEPR CNTN1	3.55e-04	412	49	6	gudmap_developingKidney_e15.5_Pelvic Mesenchyme_500
CoexpressionAtlas	DevelopingKidney_e15.5_Peripheral blastema_emap-27731_k-means-cluster#4_top-relative-expression-ranked_200	NEGR1 LEPR	4.66e-04	14	49	2	gudmap_developingKidney_e15.5_Peripheral blastema_200_k4
CoexpressionAtlas	DevelopingKidney_e15.5_Podocyte cells_emap-27915_top-relative-expression-ranked_200	B3GALT1 NEGR1 LEPR CNTN1	5.05e-04	160	49	4	gudmap_developingKidney_e15.5_Podocyte cells_200
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-5517_top-relative-expression-ranked_1000	TANC2 SFMBT1 CASD1 NEGR1 MYO10 HUWE1 VPS13B CNTN1	5.21e-04	818	49	8	gudmap_developingLowerUrinaryTract_e14.5_ urogenital sinus_1000
CoexpressionAtlas	DevelopingKidney_e15.5_Ureteral Smooth Musc_emap-28812_k-means-cluster#5_top-relative-expression-ranked_100	LEPR CNTN1	5.37e-04	15	49	2	gudmap_developingKidney_e15.5_Ureteral Smooth Musc_100_k5
CoexpressionAtlas	FacebaseRNAseq_e10.5_Lateral Nasal Eminence_top-relative-expression-ranked_500_k-means-cluster#2	CASD1 MID1 STRC	5.44e-04	69	49	3	Facebase_RNAseq_e10.5_Lateral Nasal Eminence_500_K2
CoexpressionAtlas	DevelopingKidney_e15.5_Pelvic Mesenchyme_emap-8241_top-relative-expression-ranked_200	B3GALT1 NEGR1 LEPR CNTN1	5.54e-04	164	49	4	gudmap_developingKidney_e15.5_Pelvic Mesenchyme_200
CoexpressionAtlas	DevelopingKidney_e15.5_Pelvic Mesenchyme_emap-8241_k-means-cluster#2_top-relative-expression-ranked_1000	FZD1 B3GALT1 NEGR1 LEPR CNTN1	6.73e-04	305	49	5	gudmap_developingKidney_e15.5_Pelvic Mesenchyme_1000_k2
CoexpressionAtlas	DevelopingKidney_e13.5_podocyte cells_emap-27773_top-relative-expression-ranked_1000	SFMBT1 B3GALT1 NEGR1 FHOD1 GPR182 HUWE1 LEPR CNTN1	6.96e-04	855	49	8	gudmap_developingKidney_e13.5_podocyte cells_1000
ToppCell	Globus_pallidus-Endothelial-ENDOTHELIAL_STALK-Flt1_1-Endothelial_Stalk.Flt1.Angpt2_(Angpt2)--\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	SERPINB10 SLC12A3 SLC19A3 CLDN19	1.88e-06	69	57	4	73b7accba3060705dcd6240e0ff47d68f2014ddd
ToppCell	Globus_pallidus-Endothelial-ENDOTHELIAL_STALK-Flt1_1-Endothelial_Stalk.Flt1.Angpt2_(Angpt2)\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	SERPINB10 SLC12A3 SLC19A3 CLDN19	1.88e-06	69	57	4	4e2e86e1da2ded562252774dc49e1b0b4274259f
ToppCell	Globus_pallidus-Endothelial-ENDOTHELIAL_STALK-Flt1_1-Endothelial_Stalk.Flt1.Angpt2_(Angpt2)-\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	SERPINB10 SLC12A3 SLC19A3 CLDN19	1.88e-06	69	57	4	3b1b8b8f85440a7a88d52969bdff384a0c1a5470
ToppCell	droplet-Fat-SCAT-30m-Mesenchymal-nan\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC13A4 KIAA1755 CLDN19 PKDREJ LEPR	3.25e-06	178	57	5	5cf12927f0756c4d8a289fe4308d736382e6212e
ToppCell	Somatosensory_Cortex_(S1)-Neuronal\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HIVEP2 NEGR1 PKD1 GABBR2 CNTN1	5.46e-06	198	57	5	c01091ef18e096d792ea2a7a715764a5b215355f
ToppCell	Frontal_cortex-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	SLC13A4 GPR182 KIAA1755 LEPR	2.26e-05	129	57	4	856255fbfc7f95642000cfd7704141b2388f7c5c
ToppCell	E18.5-samps-Mesenchymal-Myofibroblast-myofibroblast_-_immature\|E18.5-samps / Age Group, Lineage, Cell class and subclass	B3GALT1 SERPINB10 CLDN20 KIAA1755	2.63e-05	134	57	4	a4b9163af68e92d047b0005fd2f98aa63846b65b
ToppCell	facs-Marrow-KLS-18m-Myeloid-CD4+_macrophage\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FZD1 XCR1 PKD1 LEPR	4.88e-05	157	57	4	5d08ff0ba9d3df9cc30f13cab2d2b395ea6f3446
ToppCell	facs-Marrow-KLS-18m-Myeloid-macrophage\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FZD1 XCR1 PKD1 LEPR	4.88e-05	157	57	4	ad9c9b7dfeee3ae46e7e593c51a0407df12195b4
ToppCell	facs-Marrow-T-cells-24m-Lymphocytic-pre_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIAA1755 STRC PKDREJ CNGA2	5.00e-05	158	57	4	f296ca24fdedc33f1d24b79e7660763114ce7fa3
ToppCell	facs-Marrow-T-cells-24m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIAA1755 STRC PKDREJ CNGA2	5.00e-05	158	57	4	8c7108f2c40d97a317762ba0b8eca76542b2ebaf
ToppCell	droplet-Kidney-KIDNEY-1m-Lymphocytic-CD45\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	XCR1 SERPINB10 NEGR1 CMTM7	5.25e-05	160	57	4	5bec867def73fa8531f8dad611679f4b44f573bd
ToppCell	TCGA-Kidney-Solid_Tissue_Normal\|TCGA-Kidney / Sample_Type by Project: Shred V9	SLC12A3 GPR182 CLDN19 CNTN1	5.51e-05	162	57	4	65549ffdbfe8619693345db78e6ddbdde7b742c9
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-proliferative_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	NEGR1 FHOD1 KIAA1755 CNTN1	5.51e-05	162	57	4	bfaeff19bb56598fdc8c82be71d51787cf13928f
ToppCell	TCGA-Kidney-Solid_Tissue_Normal-Kidney-Kidney_normal_tissue\|TCGA-Kidney / Sample_Type by Project: Shred V9	SLC12A3 GPR182 CLDN19 CNTN1	5.51e-05	162	57	4	a0367e9af78e4699b9d89d3e0597589e644f844c
ToppCell	TCGA-Kidney-Solid_Tissue_Normal-Kidney\|TCGA-Kidney / Sample_Type by Project: Shred V9	SLC12A3 GPR182 CLDN19 CNTN1	5.51e-05	162	57	4	d007ec42d6458431f6c490df61de7a9caef857f0
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Myeloid-Macrophage-macrophage,_alveolar-Macro_c3-EREG\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	FFAR2 FHOD1 CCR4 SIGLEC1	6.65e-05	170	57	4	9ac1ef57f14418a5dd2aa16861c3df698c28f5ed
ToppCell	droplet-Lung-LUNG-1m-Epithelial-Club_Cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLDN19 EFCAB7 PKDREJ FITM2	9.41e-05	186	57	4	e52cf44989c57c433bf82e9fa13b4643e88f3577
ToppCell	droplet-Limb_Muscle-nan-24m-Macroglial-unknown\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FZD1 SLC13A4 NEGR1 CLDN19	9.41e-05	186	57	4	ea936e66ae4b7b40564711fad60ac0137327995f
ToppCell	droplet-Lung-LUNG-1m-Epithelial-club_cell_of_bronchiole\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLDN19 EFCAB7 PKDREJ FITM2	9.41e-05	186	57	4	4c0b59d845b79323e7a3287e7c4d249f5f322556
ToppCell	droplet-Limb_Muscle-nan-24m-Macroglial\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FZD1 SLC13A4 NEGR1 CLDN19	9.61e-05	187	57	4	a0bd2b0ec9e73521c245037b1dd51ff8cf24cbf5
ToppCell	droplet-Limb_Muscle-nan-24m-Macroglial-Schwann_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FZD1 SLC13A4 NEGR1 CLDN19	9.61e-05	187	57	4	f2af79a20438108c814a73f9e24cd986d537237f
ToppCell	droplet-Kidney-nan-3m-Epithelial-nan\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC12A3 COX7B CLDN19 PKDREJ	9.81e-05	188	57	4	6b185d0aaeea64f9ae584a9bcb9741658bb1c7bd
ToppCell	droplet-Lung-21m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l49\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	B3GALT1 KIAA1755 PKDREJ GPR176	1.11e-04	194	57	4	7826fe5eb254ac032de0d978f39585a40e0b3ee4
ToppCell	Parenchymal-NucSeq-Immune_Lymphocytic-B-B_plasma-B_plasma_IgG\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	XCR1 GPR176 CRB2 OR2AG1	1.13e-04	195	57	4	bb30ac112f8c42d113fa83a9b662e40c0685bb1e
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NEGR1 PKD1 GABBR2 CNTN1	1.15e-04	196	57	4	676c56b44ac29f7baecb62f49bb8597cc74c0a88
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HIVEP2 NEGR1 GABBR2 CNTN1	1.20e-04	198	57	4	8ab40fae14fe02e39bc8c8da187a5cd60c787643
ToppCell	Neuronal\|World / cells hierarchy compared to all cells using T-Statistic	NEGR1 PKD1 GABBR2 CNTN1	1.24e-04	200	57	4	48d801219bc771d6c7e151dc88ca4c179988de85
ToppCell	Sepsis-ICU-SEP-Myeloid-cDC2\|ICU-SEP / Disease, condition lineage and cell class	FZD1 XCR1 NEGR1 CATSPERG	1.24e-04	200	57	4	09d5c3a3d2b42b15c769dc2bc14b6c0d5cc38f91
Disease	autosomal recessive nonsyndromic deafness 16 (implicated_via_orthology)	STRC STRCP1	3.17e-06	2	53	2	DOID:0110471 (implicated_via_orthology)
Disease	immunoglobulin M measurement	SIGLEC1 CMTM7	1.13e-04	9	53	2	EFO_0020466
Disease	quinate measurement	GRID1 LEPR	3.27e-04	15	53	2	EFO_0021167
Disease	longitudinal BMI measurement	MYO10 HHAT LEPR	4.38e-04	82	53	3	EFO_0005937
Disease	serum IgM measurement	SIGLEC1 CMTM7	7.15e-04	22	53	2	EFO_0004993
Disease	Renal glomerular disease	SLC12A3 CRB2	7.82e-04	23	53	2	C0268731
Disease	Glomerulopathy Assessment	SLC12A3 CRB2	7.82e-04	23	53	2	C4521256
Disease	D dimer measurement	CATSPERG CNTN1	1.33e-03	30	53	2	EFO_0004507
Disease	endometriosis, unipolar depression	HIVEP2 NEGR1	2.73e-03	43	53	2	EFO_0001065, EFO_0003761

Protein segments in the cluster

Peptide	Gene	Start	Entry
QIGVTTCSIIWSEYI	CATSPERG	396	Q6ZRH7
SCLYVLTVVCWASAL	B3GALT1	6	Q9Y5Z6
LCTLTAVSWYATLVT	CLDN19	131	Q8N6F1
LTYGVITSLATWSVA	CCR4	151	P51679
ATFCIVTWTYVATQV	COX7B	46	P24311
SSLISTVWYTKEIIA	CLDN20	131	P56880
TWSCKRISTYSTIAI	NT5DC1	396	Q5TFE4
SSIYCSTWLLAGISI	FFAR2	91	O15552
SCWYLVLTLSSFTSI	NEGR1	331	Q7Z3B1
IYATSTCTEVWSNSL	GPR176	186	Q14439
ATLQATLWSYSTTVL	CRB2	491	Q5IJ48
WCTVSEVTKLLSYLC	KIAA1755	606	Q5JYT7
VTITCWASQGISSYL	IGKV1D-43	41	A0A0B4J1Z2
TFLWKVSAITVVSCL	ATP9B	1111	O43861
LYSWQILTCLSCTFL	MYO10	1626	Q9HD67
SSCVIVSWILSPSDY	LEPR	751	P48357
THLSCLEIWYTSVTV	OR6Q1	66	Q8NGQ2
ATSWILASLSALIYT	OR2AG1	146	Q9H205
LCNLSFLEIWYTTTV	OR6X1	61	Q8NH79
VWRIYVTLLSTLNSC	GPR42	256	O15529
YCSLVWESTVLLSLC	HUWE1	941	Q7Z6Z7
YSSIPLLETVSCWTL	HHAT	271	Q5VTY9
WSVLCCASTLFTVLT	FZD1	326	Q9UP38
LWSVLCFISTSTTVA	FZD5	241	Q13467
ISVVSFLTYSIWASS	CASD1	646	Q96PB1
IIVHTYSCDTWITSV	EFCAB7	551	A8K855
TLLVGTAIWYICTSI	FITM2	96	Q8N6M3
VIISITTCLAEFTWY	CNTN1	11	Q12860
TLCTVRTWILTVGYT	GABBR2	551	O75899
SWWLFTLIVCSSYTA	GRID1	636	Q9ULK0
SDTIQWLYTLCASLS	FHOD1	201	Q9Y613
SCAYVLIVTAVYWVS	SLC13A4	36	Q9UKG4
TSLSSSWIYPTVILC	SLC19A3	6	Q9BZV2
WSALQVSVGLYTSLC	PKD1	3001	P98161
CSSHLTVVLIWYGST	OR6F1	241	Q8NGZ6
ATLWSSTWLSVFYCV	TAS2R60	106	P59551
SISLYLACWSGVTSV	PKDREJ	536	Q9NTG1
YSTWALAVALSTTIL	GPR182	211	O15218
VSSSILQGLWISYST	TANC2	831	Q9HCD6
STTAICQTAVWYAVS	STRC	386	Q7RTU9
ASIWLSYKISCVTQS	CMTM7	156	Q96FZ5
YCLYWSTLTLTTIGE	CNGA2	326	Q16280
AYLITWTTCLASHLL	TMEM270	201	Q6UE05
AWVFATLATTVLYCL	XCR1	26	P46094
LSSSCTIQAYVTWNL	TRAM1L1	301	Q8N609
LCTASYDTITVHWTS	MID1	391	O15344
WTTISYLAISATIGS	SLC12A3	381	P55017
VTLTAETSCSYISWP	POPDC2	201	Q9HBU9
TCLVWTTHPAQLTYT	SIGLEC1	1106	Q9BZZ2
SNSSIIYVWCTVLTL	VPS13B	2816	Q7Z7G8
TYWVATVITTCEQLL	SFMBT1	66	Q9UHJ3
STTAICQTAVWYAVS	STRCP1	386	A6NGW2
IDCPWSIYSTVIALT	TRAPPC10	926	P48553
LRTTTTVSWCFLNYT	HIVEP2	1641	P31629
SSWSISTSLTIVYLG	SERPINB10	31	P48595
WLKCVLTVHASYLST	WDR43	526	Q15061
ETISVILWVSSYCES	NAA25	846	Q14CX7