Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	kainate selective glutamate receptor complex	GRIA4 GRIK3	1.25e-04	6	61	2	GO:0032983
Domain	YTH_domain	YTHDF1 YTHDF3	1.04e-04	5	61	2	IPR007275
Domain	YTH	YTHDF1 YTHDF3	1.04e-04	5	61	2	PS50882
Domain	YTH	YTHDF1 YTHDF3	1.04e-04	5	61	2	PF04146
Domain	ANF_lig-bd_rcpt	GRIA4 GPRC6A GRIK3	2.38e-04	37	61	3	IPR001828
Domain	ANF_receptor	GRIA4 GPRC6A GRIK3	2.38e-04	37	61	3	PF01094
Domain	Peripla_BP_I	GRIA4 GPRC6A GRIK3	2.79e-04	39	61	3	IPR028082
Domain	-	ABR PIK3CG SYT14 DYSF	1.39e-03	148	61	4	2.60.40.150
Domain	Iontro_rcpt	GRIA4 GRIK3	1.55e-03	18	61	2	IPR001320
Domain	Lig_chan-Glu_bd	GRIA4 GRIK3	1.55e-03	18	61	2	PF10613
Domain	Iono_rcpt_met	GRIA4 GRIK3	1.55e-03	18	61	2	IPR001508
Domain	Glu/Gly-bd	GRIA4 GRIK3	1.55e-03	18	61	2	IPR019594
Domain	Lig_chan-Glu_bd	GRIA4 GRIK3	1.55e-03	18	61	2	SM00918
Domain	Lig_chan	GRIA4 GRIK3	1.55e-03	18	61	2	PF00060
Domain	PBPe	GRIA4 GRIK3	1.55e-03	18	61	2	SM00079
Domain	C2_dom	ABR PIK3CG SYT14 DYSF	2.03e-03	164	61	4	IPR000008
Domain	G_patch	CHERP GPATCH4	2.54e-03	23	61	2	SM00443
Domain	G_patch_dom	CHERP GPATCH4	2.54e-03	23	61	2	IPR000467
Domain	G_PATCH	CHERP GPATCH4	2.54e-03	23	61	2	PS50174
Domain	G-patch	CHERP GPATCH4	2.54e-03	23	61	2	PF01585
Pubmed	Identification of a KRAB-zinc finger protein binding to the Rpe65 gene promoter.	ZNF492 RPE65	3.33e-06	2	64	2	16714237
Pubmed	Cytoplasmic m6A reader YTHDF3 promotes mRNA translation.	YTHDF1 YTHDF3	3.33e-06	2	64	2	28106076
Pubmed	Deletion of YTHDF1 (not YTHDF3) reduced brain and gut damage after traumatic brain injury.	YTHDF1 YTHDF3	3.33e-06	2	64	2	39081030
Pubmed	YTHDF3 facilitates translation and decay of N6-methyladenosine-modified RNA.	YTHDF1 YTHDF3	9.99e-06	3	64	2	28106072
Pubmed	YTHDF2 suppresses the plasmablast genetic program and promotes germinal center formation.	YTHDF1 YTHDF3	9.99e-06	3	64	2	35508130
Pubmed	Comprehensive Analysis of YTH Domain Family in Lung Adenocarcinoma: Expression Profile, Association with Prognostic Value, and Immune Infiltration.	YTHDF1 YTHDF3	9.99e-06	3	64	2	34497675
Pubmed	A Unified Model for the Function of YTHDF Proteins in Regulating m6A-Modified mRNA.	YTHDF1 YTHDF3	9.99e-06	3	64	2	32492408
Pubmed	Evaluation of the role of the retinal G protein-coupled receptor (RGR) in the vertebrate retina in vivo.	RDH5 RPE65	9.99e-06	3	64	2	12716426
Pubmed	m6A-binding YTHDF proteins promote stress granule formation.	YTHDF1 YTHDF3	9.99e-06	3	64	2	32451507
Pubmed	m6A enhances the phase separation potential of mRNA.	YTHDF1 YTHDF3	9.99e-06	3	64	2	31292544
Pubmed	N(6)-methyladenosine of HIV-1 RNA regulates viral infection and HIV-1 Gag protein expression.	YTHDF1 YTHDF3	9.99e-06	3	64	2	27371828
Pubmed	Synaptotagmin gene content of the sequenced genomes.	SYT14 SYT14P1	2.00e-05	4	64	2	15238157
Pubmed	N6-methyladenosine-dependent regulation of messenger RNA stability.	YTHDF1 YTHDF3	2.00e-05	4	64	2	24284625
Pubmed	Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia.	TJP2 RDH5 GRIA4	2.10e-05	29	64	3	23396134
Pubmed	Context-dependent functional compensation between Ythdf m6A reader proteins.	YTHDF1 YTHDF3	3.32e-05	5	64	2	32943573
Pubmed	Expression and heteromeric interactions of non-N-methyl-D-aspartate glutamate receptor subunits in the developing and adult cerebellum.	GRIA4 GRIK3	3.32e-05	5	64	2	9466455
Pubmed	Vulnerability of white matter towards antenatal hypoxia is linked to a species-dependent regulation of glutamate receptor subunits.	GRIA4 GRIK3	4.98e-05	6	64	2	18922769
Pubmed	Glutamate receptors in cortical plasticity: molecular and cellular biology.	GRIA4 GRIK3	6.96e-05	7	64	2	9016303
Pubmed	Glutamate receptors: brain function and signal transduction.	GRIA4 GRIK3	6.96e-05	7	64	2	9651535
Pubmed	Primary structure and expression of the gamma 2 subunit of the glutamate receptor channel selective for kainate.	GRIA4 GRIK3	6.96e-05	7	64	2	1310861
Pubmed	Association analysis of the glutamic acid decarboxylase 2 and the glutamine synthetase genes (GAD2, GLUL) with schizophrenia.	GRIA4 GRIK3	9.27e-05	8	64	2	19125103
Pubmed	Transmembrane topology of the glutamate receptor subunit GluR6.	GRIA4 GRIK3	9.27e-05	8	64	2	8163463
Pubmed	Expression of glutamate receptor subunit genes during development of the mouse retina.	GRIA4 GRIK3	1.19e-04	9	64	2	9051806
Pubmed	Glutamatergic gene variants impact the clinical profile of efficacy and side effects of haloperidol.	GRIA4 GRIK3	2.57e-04	13	64	2	20859245
Pubmed	Comparative interactome analysis of α-arrestin families in human and Drosophila.	CHERP ABR KCTD20 LAMB2 CPSF2	2.82e-04	313	64	5	38270169
Pubmed	Convergent animal and human evidence suggests a role of PPM1A gene in response to antidepressants.	NUP214 ALK	3.45e-04	15	64	2	20970119
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	YTHDF1 ABR AGO3 TJP2 GPATCH4 DYSF YTHDF3	3.65e-04	724	64	7	36232890
Pubmed	m6A regulation of cortical and retinal neurogenesis is mediated by the redundant m6A readers YTHDFs.	YTHDF1 YTHDF3	5.59e-04	19	64	2	36039295
Pubmed	A ubiquitin-based effector-to-inhibitor switch coordinates early brain, craniofacial, and skin development.	VPS13D KLHL21 KCTD20	5.64e-04	87	64	3	37495603
Pubmed	Microphthalmia-associated transcription factor regulates the visual cycle genes Rlbp1 and Rdh5 in the retinal pigment epithelium.	RDH5 RPE65	6.84e-04	21	64	2	26876013
Pubmed	Chromosomal localization of glutamate receptor genes: relationship to familial amyotrophic lateral sclerosis and other neurological disorders of mice and humans.	GRIA4 GRIK3	8.23e-04	23	64	2	8464923
Pubmed	The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells.	PIK3CG RTKN RNF128 SPSB3	8.26e-04	227	64	4	26410627
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	YTHDF1 AGO3 TJP2 GPATCH4 CPSF2 ALK YTHDF3 ADD3 CIDEA	8.75e-04	1371	64	9	36244648
Pubmed	Glutamate can act as a signaling molecule in mouse preimplantation embryos†.	GRIA4 GRIK3	8.96e-04	24	64	2	35746896
Pubmed	The m6A reader YTHDF2 is a negative regulator for dendrite development and maintenance of retinal ganglion cells.	YTHDF1 YTHDF3	8.96e-04	24	64	2	35179492
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	ABCA2 ABR KLHL21 SNX8 LAMB2 NUP214 DYSF NBPF1	9.27e-04	1105	64	8	35748872
Pubmed	The Maternal Microbiome Programs the m6A Epitranscriptome of the Mouse Fetal Brain and Intestine.	YTHDF1 YTHDF3	9.73e-04	25	64	2	35874829
Pubmed	Defining the membrane proteome of NK cells.	ABCA2 MGAT2 CHERP ABR AGO3 PIK3CG APLP2 CPSF2	1.32e-03	1168	64	8	19946888
Pubmed	High-throughput mapping of a dynamic signaling network in mammalian cells.	LIMS1 ARL5B TSSK3 RTKN	1.36e-03	260	64	4	15761153
Pubmed	mTORC1 activity regulates post-translational modifications of glycine decarboxylase to modulate glycine metabolism and tumorigenesis.	CHERP AGO3 TJP2 CPSF2	1.65e-03	274	64	4	34244482
Pubmed	Protein microarrays for the identification of praja1 e3 ubiquitin ligase substrates.	ABR TSSK3	1.80e-03	34	64	2	21461837
Pubmed	The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition.	CPSF2 HSD17B4 DYSF YTHDF3	1.81e-03	281	64	4	24163370
Cytoband	1p36.31	KLHL21 GPR153	1.72e-04	14	64	2	1p36.31
GeneFamily	Aminopeptidases\|CD molecules	XPNPEP2 LAP3	8.41e-04	17	46	2	104
GeneFamily	G-patch domain containing\|Minor histocompatibility antigens	CHERP GPATCH4	1.42e-03	22	46	2	579
Coexpression	BCAT_GDS748_DN	SLC27A6 RDH5 SLC35E3 LAP3	4.19e-06	45	63	4	M2677
ToppCell	TCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Oligoastrocytoma-9\|TCGA-Brain / Sample_Type by Project: Shred V9	VPS13D AGO3 TJP2 RPE65 ADD3	1.44e-06	134	64	5	2647453f44b0e0a8f27ef9bba750e99eb40efc8b
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_D_(IT_RORB_THEMIS_LINC00507)_6\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PIK3CG TRPC5 SNTG2 GRIK3 CCDC144A	5.94e-06	179	64	5	1ac79c82c52fa95bb4e170ab20fec0f648db2134
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_D_(IT_RORB_THEMIS_LINC00507)_6-Exc_L6_THEMIS_LINC00343\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PIK3CG TRPC5 SNTG2 GRIK3 CCDC144A	6.27e-06	181	64	5	9de2f2cc5f02e0ca599c9e0d2cb1e1e4b5aac112
ToppCell	COVID-19_Severe-Classical_Monocyte-cMono_2\|COVID-19_Severe / Disease condition and Cell class	LIMS1 ARL5B FAXDC2 APLP2 NUP214	8.78e-06	194	64	5	9a9dd34c2e1da1c67c3d9ba99b329966cb9f41d1
Drug	Nifenazone [2139-47-1]; Up 200; 13uM; HL60; HG-U133A	VPS13D CHERP PIK3CG KLHL21 KCTD20 APLP2 NUP214	1.43e-06	199	64	7	1439_UP
Disease	Abnormality of refraction	MAP4K5 SYT14 TJP2 RDH5 GRIA4 CPSF2 ADD3 PDE11A	6.32e-05	673	60	8	HP_0000539
Disease	Myopia	TJP2 RDH5 GRIA4 CPSF2 DYSF PDE11A	1.31e-04	385	60	6	HP_0000545
Disease	Myopia	RDH5 GRIA4	4.20e-04	15	60	2	C0027092
Disease	pro-hydroxy-pro measurement	XPNPEP2 ALK	4.79e-04	16	60	2	EFO_0021132
Disease	IGF-1 measurement, IGFBP-3 measurement	MAP4K5 SPSB3	5.42e-04	17	60	2	EFO_0004626, EFO_0004627
Disease	refractive error, age at onset, Myopia	TJP2 RDH5 GRIA4 PDE11A	6.50e-04	193	60	4	EFO_0004847, HP_0000545, MONDO_0004892
Disease	disease of metabolism (implicated_via_orthology)	YTHDF1 YTHDF3	8.33e-04	21	60	2	DOID:0014667 (implicated_via_orthology)
Disease	proteinuria (implicated_via_orthology)	LAMB2 ADD3	1.71e-03	30	60	2	DOID:576 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
SQGMVKKESIKDGHW	ZNF354C	106	Q86Y25
KNWHTDVIEMNGIKV	ABR	606	Q12979
VVKNTHFLMWDIGGQ	ARL5B	56	Q96KC2
AGHMIGGTIWKIVKD	CPSF2	151	Q9P2I0
VNMGSHQKWKVGEIE	ADD3	356	Q9UEY8
HQKWKVGEIEFEGLM	ADD3	361	Q9UEY8
WDMRGKQFHTGVEIK	AGO3	436	Q9H9G7
WIEGVQDNMKLHKVD	NOX5	621	Q96PH1
CGKLNMHVNIQTGKW	APLP2	56	Q06481
KWAHLDIAGVMTNKD	LAP3	476	P28838
KVDVKTWKSTEHNMG	MGAT2	306	Q10469
IQMSWEKEEGKSRHV	KCTD20	351	Q7Z5Y7
GMKFAEEQLLKHGWT	GPATCH4	11	Q5T3I0
ILQAIMEKAGQNGWH	GRIA4	166	P48058
KQEMVEKWLQRHSQG	PDE11A	31	Q9HCR9
SNAKKQAVHTVMGIW	GPR153	121	Q6NV75
KAGAWTHVKGNMPNQ	MDM1	321	Q8TC05
KQGHQWKDSDPVMAG	NUP214	691	P35658
FWHMQEKLGIVQGIV	LAMB2	1231	P55268
MAVDIGGHRWDQVKK	NBPF1	866	Q3BBV0
VVLWKEINGHMTVTK	GPRC6A	476	Q5T6X5
EHAAWLLVKQEMGKQ	PUS10	156	Q3MIT2
NEKSKQEGHIWGSMR	FAXDC2	11	Q96IV6
QHLMKVQGTIKWRED	IL1RL1	501	Q01638
EWDKIPSMNQVHVGG	KLHL21	491	Q9UJP4
EENKGHQMLVKMGWS	CHERP	841	Q8IWX8
GMKDRHWQQISEIVG	DNAH3	951	Q8TD57
QIDIMVAHKKSEWEG	CEP63	31	Q96MT8
EMWKEGNRIHFQTKV	HSD17B4	576	P51659
VVEGSKQWHMIGHLQ	CDON	881	Q4KMG0
HVQKSEEMWIEQGKL	CCDC144B	271	Q3MJ40
EVMKTMGLNNAVHWV	ABCA2	736	Q9BZC7
HMTTKKIPGWQAEVG	KLF11	476	O14901
EEMHVKNGWAMCGKQ	DEFB126	41	Q9BYW3
HVQKSEEMWIEQGKL	CCDC144A	271	A2RUR9
DKGQWNGMVKELIDH	GRIK3	496	Q13003
KGWMIGFEEHKQKTD	DYSF	1841	O75923
TLENGSMIHVQKWLG	FABP9	86	Q0Z7S8
TGRQGEKEEHKWGME	CCDC159	81	P0C7I6
EKEEHKWGMEQGRQE	CCDC159	86	P0C7I6
WKHGMQGKSFKSDEV	MAP4K5	786	Q9Y4K4
AGEMQNWAQVHGVLK	RTKN	321	Q9BST9
SNETMGVWLHIADKK	RPE65	281	Q16518
ELNHWTEMKESKGQQ	SYT14	531	Q8NB59
SQIQGHKEMSKVWND	SNX8	421	Q9Y5X2
MVIEVGKKHGPWVNH	RNF128	191	Q8TEB7
QVVHMGWVNEKLQGA	SNTG2	296	Q9NY99
TKELGEGQHFWEIKM	SPSB3	141	Q6PJ21
EGRVVNAMGKQWHVE	LIMS1	201	P48059
QAAKWVEMHVKEAGL	RDH5	91	Q92781
GEELNHWTEMKESKG	SYT14P1	161	Q58G82
NKTGKEQGRMVWHVA	ALK	571	Q9UM73
ILEKGQKWMPGSQHV	CIDEA	101	O60543
VAGHGNVEQMKAQVW	PIK3CG	61	P48736
VLHMWQISGKGEDQG	PIK3CG	481	P48736
KHNMNIGTWDEKGSV	YTHDF3	271	Q7Z739
QHQQGEAVWVSEGKM	TJP2	876	Q9UDY2
HDSKKGDVWSMGVVL	TSSK3	186	Q96PN8
GITTQHEIWRGQMSK	TMEM44	211	Q2T9K0
VNGNPVVMKDGKWVV	TTLL3	306	Q9Y4R7
QGKEPWNVKRHEMVA	ZNF492	26	Q9P255
EQGKEPWNVKRHEMV	ZNF98	66	A6NK75
LLMHKWGDGQEEQVT	TRPC5	956	Q9UL62
WQEKVSGVRSQMQKH	XPNPEP2	216	O43895
MRNEQGWCIHVKKGE	SLC27A6	406	Q9Y2P4
VWVGAKQHELQVNSM	SLC35E3	171	Q7Z769
KHNMDIGTWDNKGPV	YTHDF1	266	Q9BYJ9
IMVGRVKDNWKHVQD	VPS13D	826	Q5THJ4