Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	P-type divalent copper transporter activity	ATP7A ATP7B	3.16e-06	2	36	2	GO:0043682
GeneOntologyMolecularFunction	P-type monovalent copper transporter activity	ATP7A ATP7B	3.16e-06	2	36	2	GO:0140581
GeneOntologyMolecularFunction	copper ion transmembrane transporter activity	ATP7A ATP7B	8.79e-05	8	36	2	GO:0005375
GeneOntologyMolecularFunction	copper ion binding	ATP7A ATP7B F5	3.73e-04	78	36	3	GO:0005507
GeneOntologyMolecularFunction	P-type transmembrane transporter activity	ATP7A ATP7B	1.92e-03	36	36	2	GO:0140358
GeneOntologyMolecularFunction	P-type ion transporter activity	ATP7A ATP7B	1.92e-03	36	36	2	GO:0015662
GeneOntologyMolecularFunction	transition metal ion transmembrane transporter activity	ATP7A ATP7B	2.85e-03	44	36	2	GO:0046915
GeneOntologyBiologicalProcess	positive regulation of mRNA splicing, via spliceosome	RBMY1D RBMY1B RBMY1E RBMY1A1 RBMY1C RBMY1F	1.46e-10	44	37	6	GO:0048026
GeneOntologyBiologicalProcess	positive regulation of mRNA processing	RBMY1D RBMY1B RBMY1E RBMY1A1 RBMY1C RBMY1F	2.88e-10	49	37	6	GO:0050685
GeneOntologyBiologicalProcess	positive regulation of RNA splicing	RBMY1D RBMY1B RBMY1E RBMY1A1 RBMY1C RBMY1F	1.37e-09	63	37	6	GO:0033120
GeneOntologyBiologicalProcess	regulation of mRNA splicing, via spliceosome	RBMY1D RBMY1B RBMY1E RBMY1A1 RBMY1C RBMY1F	1.06e-07	129	37	6	GO:0048024
GeneOntologyBiologicalProcess	positive regulation of mRNA metabolic process	RBMY1D RBMY1B RBMY1E TARDBP RBMY1A1 RBMY1C RBMY1F	3.39e-07	259	37	7	GO:1903313
GeneOntologyBiologicalProcess	regulation of mRNA processing	RBMY1D RBMY1B RBMY1E RBMY1A1 RBMY1C RBMY1F	3.51e-07	158	37	6	GO:0050684
GeneOntologyBiologicalProcess	regulation of RNA splicing	RBMY1D RBMY1B RBMY1E RBMY1A1 RBMY1C RBMY1F	1.70e-06	207	37	6	GO:0043484
GeneOntologyBiologicalProcess	copper ion export	ATP7A ATP7B	9.38e-06	3	37	2	GO:0060003
GeneOntologyBiologicalProcess	regulation of mRNA metabolic process	RBMY1D RBMY1B RBMY1E TARDBP RBMY1A1 RBMY1C RBMY1F	1.19e-05	443	37	7	GO:1903311
GeneOntologyBiologicalProcess	RNA splicing	RBMY1D RBMY1B RBMY1E TARDBP RBMY1A1 RBMY1C RBMY1F	2.65e-05	502	37	7	GO:0008380
GeneOntologyBiologicalProcess	mRNA splicing, via spliceosome	RBMY1D RBMY1B RBMY1E RBMY1A1 RBMY1C RBMY1F	3.87e-05	358	37	6	GO:0000398
GeneOntologyBiologicalProcess	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	RBMY1D RBMY1B RBMY1E RBMY1A1 RBMY1C RBMY1F	3.87e-05	358	37	6	GO:0000377
GeneOntologyBiologicalProcess	RNA splicing, via transesterification reactions	RBMY1D RBMY1B RBMY1E RBMY1A1 RBMY1C RBMY1F	4.12e-05	362	37	6	GO:0000375
GeneOntologyBiologicalProcess	mRNA processing	RBMY1D RBMY1B RBMY1E TARDBP RBMY1A1 RBMY1C RBMY1F	4.80e-05	551	37	7	GO:0006397
GeneOntologyBiologicalProcess	copper ion import	ATP7A ATP7B	1.12e-04	9	37	2	GO:0015677
GeneOntologyBiologicalProcess	copper ion transmembrane transport	ATP7A ATP7B	1.12e-04	9	37	2	GO:0035434
GeneOntologyBiologicalProcess	positive regulation of gene expression	RBMY1D RBMY1B RBMY1E FADD TARDBP C5 NFAT5 RBMY1A1 RBMY1C RBMY1F	1.68e-04	1446	37	10	GO:0010628
GeneOntologyBiologicalProcess	male gonad development	RBMY1D RBMY1B RBMY1E RBMY1A1	2.43e-04	171	37	4	GO:0008584
GeneOntologyBiologicalProcess	development of primary male sexual characteristics	RBMY1D RBMY1B RBMY1E RBMY1A1	2.49e-04	172	37	4	GO:0046546
GeneOntologyBiologicalProcess	response to water	PLEC NFAT5	2.81e-04	14	37	2	GO:0009415
GeneOntologyBiologicalProcess	hematopoietic progenitor cell differentiation	RBMY1D RBMY1B RBMY1E RBMY1A1	4.17e-04	197	37	4	GO:0002244
GeneOntologyBiologicalProcess	male sex differentiation	RBMY1D RBMY1B RBMY1E RBMY1A1	4.33e-04	199	37	4	GO:0046661
GeneOntologyBiologicalProcess	copper ion transport	ATP7A ATP7B	5.83e-04	20	37	2	GO:0006825
GeneOntologyBiologicalProcess	intracellular copper ion homeostasis	ATP7A ATP7B	5.83e-04	20	37	2	GO:0006878
GeneOntologyBiologicalProcess	cellular response to fluid shear stress	PLEC MTSS1	7.74e-04	23	37	2	GO:0071498
GeneOntologyBiologicalProcess	copper ion homeostasis	ATP7A ATP7B	7.74e-04	23	37	2	GO:0055070
GeneOntologyBiologicalProcess	cellular response to copper ion	ATP7A ATP7B	1.07e-03	27	37	2	GO:0071280
GeneOntologyBiologicalProcess	mRNA metabolic process	RBMY1D RBMY1B RBMY1E TARDBP RBMY1A1 RBMY1C RBMY1F	1.07e-03	917	37	7	GO:0016071
GeneOntologyBiologicalProcess	regulation of body fluid levels	ATP7A ATP7B NFAT5 F5 SERPINB2	1.09e-03	442	37	5	GO:0050878
GeneOntologyCellularComponent	spliceosomal complex	RBMY1D RBMY1B RBMY1E RBMY1A1 RBMY1C RBMY1F	1.66e-06	215	36	6	GO:0005681
GeneOntologyCellularComponent	male germ cell nucleus	RBMY1D RBMY1B RBMY1E RBMY1A1	1.42e-05	86	36	4	GO:0001673
GeneOntologyCellularComponent	germ cell nucleus	RBMY1D RBMY1B RBMY1E RBMY1A1	4.17e-05	113	36	4	GO:0043073
MousePheno	increased brain copper level	ATP7A ATP7B	3.07e-06	2	25	2	MP:0011214
MousePheno	abnormal kidney copper level	ATP7A ATP7B	3.07e-06	2	25	2	MP:0010242
MousePheno	increased kidney copper level	ATP7A ATP7B	3.07e-06	2	25	2	MP:0010243
MousePheno	decreased circulating copper level	ATP7A ATP7B	9.20e-06	3	25	2	MP:0006349
MousePheno	decreased liver copper level	ATP7A ATP7B	9.20e-06	3	25	2	MP:0003067
MousePheno	increased copper level	ATP7A ATP7B	1.84e-05	4	25	2	MP:0014539
MousePheno	abnormal circulating copper level	ATP7A ATP7B	1.84e-05	4	25	2	MP:0006348
MousePheno	abnormal brain copper level	ATP7A ATP7B	3.06e-05	5	25	2	MP:0011213
MousePheno	decreased copper level	ATP7A ATP7B	3.06e-05	5	25	2	MP:0014540
MousePheno	abnormal liver copper level	ATP7A ATP7B	4.59e-05	6	25	2	MP:0003065
MousePheno	hemothorax	CARM1 ATP7A	1.37e-04	10	25	2	MP:0005243
MousePheno	abnormal copper level	ATP7A ATP7B	1.37e-04	10	25	2	MP:0003952
MousePheno	abnormal copper homeostasis	ATP7A ATP7B	1.67e-04	11	25	2	MP:0003951
MousePheno	lethality during fetal growth through weaning, complete penetrance	CARM1 MAST1 TARDBP ATP7A PLEC ATP7B ATE1 NFAT5 F5	2.17e-04	1269	25	9	MP:0011111
MousePheno	ventricle myocardium hypoplasia	FADD TEAD1 ATE1	2.67e-04	71	25	3	MP:0010502
MousePheno	abnormal intercalated disk morphology	PLEC ATE1	4.62e-04	18	25	2	MP:0006267
MousePheno	myocardium hypoplasia	FADD TEAD1 ATE1	4.69e-04	86	25	3	MP:0010500
MousePheno	lethality throughout fetal growth and development, incomplete penetrance	CARM1 ATP7A ATE1 NFAT5	4.71e-04	208	25	4	MP:0011109
MousePheno	abnormal frontal lobe morphology	TARDBP ATP7B	5.72e-04	20	25	2	MP:0000798
MousePheno	ventricular hypoplasia	FADD TEAD1 ATE1	7.08e-04	99	25	3	MP:0000279
MousePheno	abnormal myocardium layer morphology	FADD TEAD1 PLEC ATE1 NFAT5	7.24e-04	414	25	5	MP:0005329
MousePheno	abnormal heart layer morphology	FADD TEAD1 PLEC ATE1 NFAT5	7.89e-04	422	25	5	MP:0010545
MousePheno	heart hypoplasia	FADD TEAD1 ATE1	7.94e-04	103	25	3	MP:0002740
MousePheno	hemorrhage	CARM1 FADD ATP7A PLEC ATE1 F5	9.16e-04	664	25	6	MP:0001914
MousePheno	curly vibrissae	ATP7A ATP7B	9.72e-04	26	25	2	MP:0001274
MousePheno	abnormal ventricle myocardium morphology	FADD TEAD1 ATE1	1.12e-03	116	25	3	MP:0010499
MousePheno	abnormal cardiac muscle tissue morphology	FADD TEAD1 PLEC ATE1 NFAT5	1.53e-03	489	25	5	MP:0010630
MousePheno	increased skeletal muscle fiber size	ATP7A PLEC	1.86e-03	36	25	2	MP:0009399
MousePheno	abnormal myocardial trabeculae morphology	FADD TEAD1 NFAT5	2.09e-03	144	25	3	MP:0002189
MousePheno	decreased fibroblast cell migration	PLEC MTSS1	2.18e-03	39	25	2	MP:0011708
Domain	RBM1CTR	RBMY1D RBMY1B RBMY1E RBMY1A1 RBMY1F	1.11e-12	8	36	5	PF08081
Domain	RBM1CTR	RBMY1D RBMY1B RBMY1E RBMY1A1 RBMY1F	1.11e-12	8	36	5	IPR012604
Domain	RRM_1	RBMY1D RBMY1B RBMY1E TARDBP RBMY1A1 RBMY1F ENOX2	1.22e-07	208	36	7	PF00076
Domain	RRM	RBMY1D RBMY1B RBMY1E TARDBP RBMY1A1 RBMY1F ENOX2	1.63e-07	217	36	7	SM00360
Domain	RRM_dom	RBMY1D RBMY1B RBMY1E TARDBP RBMY1A1 RBMY1F ENOX2	2.21e-07	227	36	7	IPR000504
Domain	RRM	RBMY1D RBMY1B RBMY1E TARDBP RBMY1A1 RBMY1F ENOX2	2.41e-07	230	36	7	PS50102
Domain	Nucleotide-bd_a/b_plait	RBMY1D RBMY1B RBMY1E TARDBP RBMY1A1 RBMY1F ENOX2	5.25e-07	258	36	7	IPR012677
Domain	P-typ_ATPase_IB	ATP7A ATP7B	3.61e-06	2	36	2	IPR027256
Domain	HMA_Cu_ion-bd	ATP7A ATP7B	3.61e-06	2	36	2	IPR006122
Domain	-	RBMY1D RBMY1B RBMY1E TARDBP RBMY1F ENOX2	6.56e-06	244	36	6	3.30.70.330
Domain	Heavy-metal-associated_CS	ATP7A ATP7B	1.08e-05	3	36	2	IPR017969
Domain	HMA_2	ATP7A ATP7B	2.16e-05	4	36	2	PS50846
Domain	HMA_1	ATP7A ATP7B	2.16e-05	4	36	2	PS01047
Domain	HMA	ATP7A ATP7B	2.16e-05	4	36	2	PF00403
Domain	HMA_dom	ATP7A ATP7B	7.54e-05	7	36	2	IPR006121
Domain	-	ATP7A ATP7B	1.73e-03	32	36	2	2.70.150.10
Domain	-	ATP7A ATP7B	1.73e-03	32	36	2	3.40.1110.10
Domain	ATPase_P-typ_cyto_domN	ATP7A ATP7B	2.07e-03	35	36	2	IPR023299
Domain	ATPase_P-typ_P_site	ATP7A ATP7B	2.18e-03	36	36	2	IPR018303
Domain	P_typ_ATPase	ATP7A ATP7B	2.18e-03	36	36	2	IPR001757
Domain	ATPASE_E1_E2	ATP7A ATP7B	2.18e-03	36	36	2	PS00154
Domain	ATPase_P-typ_transduc_dom_A	ATP7A ATP7B	2.31e-03	37	36	2	IPR008250
Domain	E1-E2_ATPase	ATP7A ATP7B	2.31e-03	37	36	2	PF00122
Domain	-	ATP7A ATP7B	6.76e-03	64	36	2	3.40.50.1000
Domain	HAD-like_dom	ATP7A ATP7B	1.01e-02	79	36	2	IPR023214
Pubmed	A Y chromosome gene family with RNA-binding protein homology: candidates for the azoospermia factor AZF controlling human spermatogenesis.	RBMY1D RBMY1B RBMY1E RBMY1A1 RBMY1C RBMY1F	6.62e-18	7	37	6	8269511
Pubmed	Structure and organization of the RBMY genes on the human Y chromosome: transposition and amplification of an ancestral autosomal hnRNPG gene.	RBMY1D RBMY1B RBMY1E RBMY1A1 RBMY1C RBMY1F	8.70e-16	12	37	6	9598316
Pubmed	RBMY, a male germ cell-specific RNA-binding protein, activated in human liver cancers and transforms rodent fibroblasts.	RBMY1D RBMY1B RBMY1E RBMY1A1 RBMY1F	6.16e-15	6	37	5	15184870
Pubmed	Degeneracy in human multicopy RBM (YRRM), a candidate spermatogenesis gene.	RBMY1D RBMY1B RBMY1E RBMY1A1 RBMY1F	2.16e-14	7	37	5	8875892
Pubmed	An RBM homologue maps to the mouse Y chromosome and is expressed in germ cells.	RBMY1D RBMY1B RBMY1E RBMY1A1	5.41e-12	5	37	4	8817321
Pubmed	Human RBMY regulates germline-specific splicing events by modulating the function of the serine/arginine-rich proteins 9G8 and Tra2-{beta}.	RBMY1D RBMY1B RBMY1E RBMY1A1	5.41e-12	5	37	4	20016065
Pubmed	The role of human and mouse Y chromosome genes in male infertility.	RBMY1D RBMY1B RBMY1E RBMY1A1	5.41e-12	5	37	4	11097427
Pubmed	Rapid evolution of mouse Y centromere repeat DNA belies recent sequence stability.	RBMY1D RBMY1B RBMY1E RBMY1A1	5.41e-12	5	37	4	19737860
Pubmed	The behavior of the X- and Y-chromosomes in the oocyte during meiotic prophase in the B6.Y(TIR)sex-reversed mouse ovary.	RBMY1D RBMY1B RBMY1E RBMY1A1	1.62e-11	6	37	4	18239052
Pubmed	Identification of target messenger RNA substrates for mouse RBMY.	RBMY1D RBMY1B RBMY1E RBMY1A1	1.62e-11	6	37	4	18492746
Pubmed	Meiotic sex chromosome inactivation in male mice with targeted disruptions of Xist.	RBMY1D RBMY1B RBMY1E RBMY1A1	1.62e-11	6	37	4	12356914
Pubmed	Mouse homologues of the human AZF candidate gene RBM are expressed in spermatogonia and spermatids, and map to a Y chromosome deletion interval associated with a high incidence of sperm abnormalities.	RBMY1D RBMY1B RBMY1E RBMY1A1	1.62e-11	6	37	4	9499427
Pubmed	Does Rbmy have a role in sperm development in mice?	RBMY1D RBMY1B RBMY1E RBMY1A1	1.62e-11	6	37	4	15051956
Pubmed	RNA-binding motif protein 15 binds to the RNA transport element RTE and provides a direct link to the NXF1 export pathway.	RBMY1D RBMY1B RBMY1E RBMY1A1	3.78e-11	7	37	4	17001072
Pubmed	The roles of RNA-binding proteins in spermatogenesis and male infertility.	RBMY1D RBMY1B RBMY1E RBMY1A1	3.78e-11	7	37	4	10377282
Pubmed	Y chromosome short arm-Sxr recombination in XSxr/Y males causes deletion of Rbm and XY female sex reversal.	RBMY1D RBMY1B RBMY1E RBMY1A1	7.56e-11	8	37	4	7479793
Pubmed	Mice with Y chromosome deletion and reduced Rbm genes on a heterozygous Dazl1 null background mimic a human azoospermic factor phenotype.	RBMY1D RBMY1B RBMY1E RBMY1A1	2.27e-10	10	37	4	10601091
Pubmed	Characterisation of the coding sequence and fine mapping of the human DFFRY gene and comparative expression analysis and mapping to the Sxrb interval of the mouse Y chromosome of the Dffry gene.	RBMY1D RBMY1B RBMY1E RBMY1A1	2.27e-10	10	37	4	9384609
Pubmed	The role of Dby mRNA in early development of male mouse zygotes.	RBMY1D RBMY1B RBMY1E RBMY1A1	5.33e-10	12	37	4	20543856
Pubmed	GASZ promotes germ cell derivation from embryonic stem cells.	RBMY1D RBMY1B RBMY1E RBMY1A1	7.69e-10	13	37	4	23816659
Pubmed	RBMY, a probable human spermatogenesis factor, and other hnRNP G proteins interact with Tra2beta and affect splicing.	RBMY1B RBMY1A1 RBMY1C RBMY1F	7.69e-10	13	37	4	10749975
Pubmed	Absence of mDazl produces a final block on germ cell development at meiosis.	RBMY1D RBMY1B RBMY1E RBMY1A1	1.08e-09	14	37	4	14611631
Pubmed	Evolutionary strata on the mouse X chromosome correspond to strata on the human X chromosome.	RBMY1D RBMY1B RBMY1E RBMY1A1	1.47e-09	15	37	4	14762062
Pubmed	Loss of maternal Trim28 causes male-predominant early embryonic lethality.	RBMY1D RBMY1B RBMY1E RBMY1A1	2.55e-09	17	37	4	28115466
Pubmed	A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain.	RBMY1D RBMY1B CARM1 RBMY1E DUS2 TARDBP RBMY1A1 ENOX2	2.72e-09	347	37	8	16033648
Pubmed	Sex differences in sex chromosome gene expression in mouse brain.	RBMY1D RBMY1B RBMY1E RBMY1A1	3.28e-09	18	37	4	12023983
Pubmed	MRNIP interacts with sex body chromatin to support meiotic progression, spermatogenesis, and male fertility in mice.	RBMY1D RBMY1B RBMY1E RBMY1A1	1.59e-08	26	37	4	35920200
Pubmed	Lineage-specific biology revealed by a finished genome assembly of the mouse.	RBMY1D RBMY1B RBMY1E RBMY1A1	3.56e-07	55	37	4	19468303
Pubmed	An abundance of X-linked genes expressed in spermatogonia.	RBMY1D RBMY1B RBMY1E RBMY1A1	4.73e-07	59	37	4	11279525
Pubmed	[From gene to disease: copper-transporting P ATPases alteration].	ATP7A ATP7B	1.10e-06	2	37	2	19046832
Pubmed	Copper efflux transporters ATP7A and ATP7B: Novel biomarkers for platinum drug resistance and targets for therapy.	ATP7A ATP7B	1.10e-06	2	37	2	29394468
Pubmed	Expression of the Menkes gene homologue in mouse tissues lack of effect of copper on the mRNA levels.	ATP7A ATP7B	1.10e-06	2	37	2	8082762
Pubmed	Potential dual functional roles of the Y-linked RBMY in hepatocarcinogenesis.	RBMY1B RBMY1A1	1.10e-06	2	37	2	32473614
Pubmed	Solution structures of the actuator domain of ATP7A and ATP7B, the Menkes and Wilson disease proteins.	ATP7A ATP7B	1.10e-06	2	37	2	19645496
Pubmed	Differential intracellular localisation of the Menkes and Wilson copper transporting ATPases in the third trimester human placenta.	ATP7A ATP7B	1.10e-06	2	37	2	21115196
Pubmed	Expression in mouse kidney of membrane copper transporters Atp7a and Atp7b.	ATP7A ATP7B	1.10e-06	2	37	2	12372948
Pubmed	Altered localisation of the copper efflux transporters ATP7A and ATP7B associated with cisplatin resistance in human ovarian carcinoma cells.	ATP7A ATP7B	1.10e-06	2	37	2	18565219
Pubmed	Copper transporting P-type ATPases and human disease.	ATP7A ATP7B	1.10e-06	2	37	2	12539960
Pubmed	Mechanisms of charge transfer in human copper ATPases ATP7A and ATP7B.	ATP7A ATP7B	1.10e-06	2	37	2	28164426
Pubmed	Hormonal regulation of the Menkes and Wilson copper-transporting ATPases in human placental Jeg-3 cells.	ATP7A ATP7B	1.10e-06	2	37	2	17109627
Pubmed	Quantitative relationship between mutated amino-acid sequence of human copper-transporting ATPases and their related diseases.	ATP7A ATP7B	1.10e-06	2	37	2	18688737
Pubmed	Biochemical basis of regulation of human copper-transporting ATPases.	ATP7A ATP7B	1.10e-06	2	37	2	17562324
Pubmed	Genes regulating copper metabolism.	ATP7A ATP7B	1.10e-06	2	37	2	9823011
Pubmed	Expression and localization of menkes and Wilson copper transporting ATPases in human placenta.	ATP7A ATP7B	1.10e-06	2	37	2	15135234
Pubmed	Molecular pathogenesis of Wilson and Menkes disease: correlation of mutations with molecular defects and disease phenotypes.	ATP7A ATP7B	1.10e-06	2	37	2	17717039
Pubmed	Developmental expression of the mouse mottled and toxic milk genes suggests distinct functions for the Menkes and Wilson disease copper transporters.	ATP7A ATP7B	1.10e-06	2	37	2	9215673
Pubmed	Genetic polymorphisms of copper- and platinum drug-efflux transporters ATP7A and ATP7B in Japanese cancer patients.	ATP7A ATP7B	1.10e-06	2	37	2	20045993
Pubmed	Copper-transporting ATPases ATP7A and ATP7B: cousins, not twins.	ATP7A ATP7B	1.10e-06	2	37	2	18000748
Pubmed	Regulation of the apico-basolateral trafficking polarity of the homologous copper-ATPases ATP7A and ATP7B.	ATP7A ATP7B	1.10e-06	2	37	2	38032054
Pubmed	Molecular features of copper binding proteins involved in copper homeostasis.	ATP7A ATP7B	1.10e-06	2	37	2	27896900
Pubmed	Menkes disease: recent advances and new insights into copper metabolism.	ATP7A ATP7B	1.10e-06	2	37	2	8732640
Pubmed	Trafficking of the copper-ATPases, ATP7A and ATP7B: role in copper homeostasis.	ATP7A ATP7B	1.10e-06	2	37	2	17531189
Pubmed	Intracellular targeting of copper-transporting ATPase ATP7A in a normal and Atp7b-/- kidney.	ATP7A ATP7B	1.10e-06	2	37	2	17928409
Pubmed	Dynamics of the metal binding domains and regulation of the human copper transporters ATP7B and ATP7A.	ATP7A ATP7B	1.10e-06	2	37	2	28271598
Pubmed	Fatal haemorrhage and incomplete block to embryogenesis in mice lacking coagulation factor V.	C5 F5	1.10e-06	2	37	2	8900278
Pubmed	[Structure and function of ATP7A and ATP7B proteins--Cu-transporting ATPases].	ATP7A ATP7B	1.10e-06	2	37	2	21117320
Pubmed	Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7.	RBMY1D RBMY1B RBMY1E RBMY1A1	3.22e-06	95	37	4	24029230
Pubmed	Copper-dependent interaction of glutaredoxin with the N termini of the copper-ATPases (ATP7A and ATP7B) defective in Menkes and Wilson diseases.	ATP7A ATP7B	3.30e-06	3	37	2	16884690
Pubmed	Intestinal expression of metal transporters in Wilson's disease.	ATP7A ATP7B	3.30e-06	3	37	2	23963605
Pubmed	Clusterin (apolipoprotein J), a molecular chaperone that facilitates degradation of the copper-ATPases ATP7A and ATP7B.	ATP7A ATP7B	3.30e-06	3	37	2	21242307
Pubmed	Association between polymorphisms in CTR1, CTR2, ATP7A, and ATP7B and platinum resistance in epithelial ovarian cancer.	ATP7A ATP7B	3.30e-06	3	37	2	28737129
Pubmed	ATP7A and ATP7B copper transporters have distinct functions in the regulation of neuronal dopamine-β-hydroxylase.	ATP7A ATP7B	3.30e-06	3	37	2	30341172
Pubmed	Copper chaperone Atox1 interacts with the metal-binding domain of Wilson's disease protein in cisplatin detoxification.	ATP7A ATP7B	3.30e-06	3	37	2	23751120
Pubmed	The copper-transporting ATPases, menkes and wilson disease proteins, have distinct roles in adult and developing cerebellum.	ATP7A ATP7B	3.30e-06	3	37	2	15634671
Pubmed	Interaction of the copper chaperone HAH1 with the Wilson disease protein is essential for copper homeostasis.	ATP7A ATP7B	3.30e-06	3	37	2	10557326
Pubmed	Role of glutaredoxin1 and glutathione in regulating the activity of the copper-transporting P-type ATPases, ATP7A and ATP7B.	ATP7A ATP7B	3.30e-06	3	37	2	20566629
Pubmed	Characterization of the interaction between the Wilson and Menkes disease proteins and the cytoplasmic copper chaperone, HAH1p.	ATP7A ATP7B	3.30e-06	3	37	2	10497213
Pubmed	The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes.	RBMY1D RBMY1B RBMY1E RBMY1A1 RBMY1F	5.57e-06	241	37	5	12815422
Pubmed	Clusterin and COMMD1 independently regulate degradation of the mammalian copper ATPases ATP7A and ATP7B.	ATP7A ATP7B	6.60e-06	4	37	2	22130675
Pubmed	Genomic organization of the mottled gene, the mouse homologue of the human Menkes disease gene.	ATP7A ATP7B	6.60e-06	4	37	2	8921375
Pubmed	Dual role of LRRC8A-containing transporters on cisplatin resistance in human ovarian cancer cells.	ATP7A ATP7B	6.60e-06	4	37	2	27112899
Pubmed	C5a induces caspase-dependent apoptosis in brain vascular endothelial cells in experimental lupus.	FADD C5	6.60e-06	4	37	2	27213693
Pubmed	Atp7a and Atp7b regulate copper homeostasis in developing male germ cells in mice.	ATP7A ATP7B	1.10e-05	5	37	2	28820536
Pubmed	T-STAR/ETOILE: a novel relative of SAM68 that interacts with an RNA-binding protein implicated in spermatogenesis.	RBMY1A1 RBMY1C	4.93e-05	10	37	2	10332027
Pubmed	Regional brain distribution of metallothionein, zinc and copper in toxic milk mutant and transgenic mice.	ATP7A ATP7B	6.02e-05	11	37	2	9392450
Pubmed	Card9 protects fungal peritonitis through regulating Malt1-mediated activation of autophagy in macrophage.	TARDBP PLEC	7.22e-05	12	37	2	35850054
Pubmed	Candidate genes and cerebral palsy: a population-based study.	F5 SERPINB2	2.28e-04	21	37	2	18977990
Pubmed	Cytokinesis involves a nontranscriptional function of the Hippo pathway effector YAP.	TEAD1 PLEC	2.75e-04	23	37	2	26933062
Pubmed	Biology, structure and mechanism of P-type ATPases.	ATP7A ATP7B	4.39e-04	29	37	2	15071553
Pubmed	Early embryonic expression of murine coagulation system components.	F5 SERPINB2	6.05e-04	34	37	2	11154109
Pubmed	The genomic basis of cerebral palsy: a HuGE systematic literature review.	F5 SERPINB2	6.05e-04	34	37	2	19238444
Interaction	MALT1 interactions	PLEKHA4 CARM1 TARDBP PLEC	1.12e-05	76	37	4	int:MALT1
Interaction	RBMY1E interactions	RBMY1E RBMY1F	1.96e-05	4	37	2	int:RBMY1E
Interaction	RBMY1J interactions	RBMY1E RBMY1A1 RBMY1F	2.01e-05	29	37	3	int:RBMY1J
Interaction	RBMY1F interactions	RBMY1E RBMY1A1 RBMY1F	3.90e-05	36	37	3	int:RBMY1F
Interaction	NOA1 interactions	PLEKHA4 MAST1 ATE1 ZNF460	5.00e-05	111	37	4	int:NOA1
Cytoband	Yq11.223	RBMY1D RBMY1B RBMY1E RBMY1A1 RBMY1F	1.27e-08	93	37	5	Yq11.223
Cytoband	Ensembl 112 genes in cytogenetic band chrYq11	RBMY1D RBMY1B RBMY1E RBMY1A1 RBMY1F	5.04e-06	311	37	5	chrYq11
Cytoband	19p13.2	CARM1 MAST1 OLFM2	8.40e-04	229	37	3	19p13.2
Cytoband	16q22.1	DUS2 NFAT5	3.59e-03	110	37	2	16q22.1
GeneFamily	RNA binding motif containing	RBMY1D RBMY1B RBMY1E TARDBP RBMY1A1 RBMY1C RBMY1F ENOX2	1.52e-09	213	30	8	725
GeneFamily	ATPase copper transporting	ATP7A ATP7B	2.66e-06	2	30	2	1212
Coexpression	CHEN_ETV5_TARGETS_TESTIS	RBMY1D RBMY1B RBMY1E RBMY1A1	1.19e-07	33	36	4	MM701
Coexpression	ZHENG_IL22_SIGNALING_DN	RBMY1D RBMY1B RBMY1E RBMY1A1	4.29e-07	45	36	4	MM763
Coexpression	XIE_TRASTUZUMAB_CARDIOTOXICITY_MMU_MIR_345_5P_GENES	FBXL17 TEAD1 ATE1 VSIG10	4.40e-06	80	36	4	MM17502
Coexpression	GSE360_CTRL_VS_B_MALAYI_HIGH_DOSE_DC_UP	ZNF75D TARDBP CBFA2T3 ZNF460	1.51e-04	197	36	4	M5150
Coexpression	IVANOVA_HEMATOPOIESIS_STEM_CELL_AND_PROGENITOR	RBMY1D RBMY1B RBMY1E MFNG CBFA2T3 RBMY1A1	1.52e-04	600	36	6	MM1025
Coexpression	GSE24574_BCL6_HIGH_TFH_VS_TCONV_CD4_TCELL_UP	ATP7A ATP7B F5 ZNF460	1.54e-04	198	36	4	M8335
Coexpression	GSE41176_WT_VS_TAK1_KO_UNSTIM_BCELL_DN	DUS2 ATP7B SYT12 SVOP	1.57e-04	199	36	4	M9941
Coexpression	GSE2770_UNTREATED_VS_TGFB_AND_IL4_TREATED_ACT_CD4_TCELL_2H_DN	DUS2 NFAT5 DCXR MTSS1	1.57e-04	199	36	4	M6015
Coexpression	GSE18203_CTRL_VS_INTRATUMORAL_CPG_INJ_MC38_TUMOR_UP	MFNG PLEC SYT12 MTSS1	1.60e-04	200	36	4	M7207
Coexpression	GSE5589_LPS_VS_LPS_AND_IL6_STIM_IL6_KO_MACROPHAGE_45MIN_UP	TARDBP LMAN2L DCXR MTSS1	1.60e-04	200	36	4	M6620
Coexpression	GSE42021_TCONV_PLN_VS_CD24LO_TCONV_THYMUS_DN	TARDBP TEAD1 F5 SERPINB2	1.60e-04	200	36	4	M9606
ToppCell	tumor_Lymph_Node_/_Brain-Fibroblasts-Undetermined\|Fibroblasts / Location, Cell class and cell subclass	DUS2 LMAN2L DCXR ENOX2	1.19e-05	186	34	4	403ac98f72a42721f84fbd7826f251a88ae534a2
ToppCell	356C-Myeloid-Monocyte-CD14+_Monocyte\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	NFAT5 F5 MTSS1 SERPINB2	1.40e-05	194	34	4	3f9ac1de8605a7930f49a7ce0e32aea9997d7791
ToppCell	356C-Myeloid-Monocyte\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	NFAT5 F5 MTSS1 SERPINB2	1.40e-05	194	34	4	a41cde3088b43670210daab4f43a24aa83dbd45b
Drug	hydantoin-5-propionic acid	RBMY1D RBMY1B RBMY1E RBMY1A1	3.09e-08	21	36	4	CID000000782
Drug	AZFd	RBMY1D RBMY1B RBMY1E RBMY1A1	4.56e-08	23	36	4	CID000196489
Drug	Vistar	RBMY1D RBMY1B RBMY1E RBMY1A1	2.99e-07	36	36	4	CID000040896
Drug	2-chlorodideoxyadenosine	RBMY1D RBMY1B RBMY1E RBMY1A1	6.22e-07	43	36	4	CID000072194
Drug	PKI166	RBMY1D RBMY1B RBMY1E RBMY1A1	9.74e-07	48	36	4	CID006918403
Drug	HgCl	RBMY1D RBMY1B RBMY1E RBMY1A1	1.06e-06	49	36	4	CID000024182
Drug	azafagomine	RBMY1D RBMY1B RBMY1E RBMY1A1	1.96e-06	57	36	4	CID011957435
Drug	thioglycolate	RBMY1D RBMY1B RBMY1E RBMY1A1	3.76e-06	67	36	4	CID000001133
Drug	SU6668	RBMY1D RBMY1B RBMY1E RBMY1A1	4.48e-06	70	36	4	CID000206042
Drug	p11-13	RBMY1D RBMY1B RBMY1E RBMY1A1	5.91e-06	75	36	4	CID000015759
Drug	glutamin	RBMY1D RBMY1B RBMY1E FADD TARDBP NFAT5 RBMY1A1	6.70e-06	461	36	7	CID000000738
Drug	bipy	RBMY1D RBMY1B RBMY1E RBMY1A1	1.64e-05	97	36	4	CID000001474
Drug	2-oyl	RBMY1D RBMY1B RBMY1E RBMY1A1	2.25e-05	105	36	4	CID000657137
Drug	satraplatin	ATP7A ATP7B	2.42e-05	5	36	2	ctd:C081294
Drug	h CBDCA	FADD ATP7A ATP7B	2.72e-05	37	36	3	CID000002568
Drug	satraplatin	C5 ATP7A ATP7B	2.72e-05	37	36	3	CID006918220
Drug	carbonyl sulfide	RBMY1D RBMY1B RBMY1E RBMY1A1	3.32e-05	116	36	4	CID000010039
Drug	7a-8	FADD PLEC	5.08e-05	7	36	2	CID000447259
Drug	oligoadenylate	RBMY1D RBMY1B RBMY1E RBMY1A1	1.08e-04	157	36	4	CID000107918
Disease	occipital horn syndrome (implicated_via_orthology)	ATP7A ATP7B	1.07e-06	2	31	2	DOID:0111272 (implicated_via_orthology)
Disease	metal metabolism disorder (implicated_via_orthology)	ATP7A ATP7B	6.40e-06	4	31	2	DOID:896 (implicated_via_orthology)
Disease	Wilson disease (implicated_via_orthology)	ATP7A ATP7B	1.07e-05	5	31	2	DOID:893 (implicated_via_orthology)
Disease	Menkes disease (implicated_via_orthology)	ATP7A ATP7B	1.07e-05	5	31	2	DOID:1838 (implicated_via_orthology)
Disease	spinal muscular atrophy (implicated_via_orthology)	ATP7A ATP7B	3.83e-05	9	31	2	DOID:12377 (implicated_via_orthology)
Disease	diastolic blood pressure, systolic blood pressure	FADD FBXL17 OLFM2 CBFA2T3 NFAT5	6.19e-04	670	31	5	EFO_0006335, EFO_0006336
Disease	liver cirrhosis (is_implicated_in)	C5 F5	9.39e-04	43	31	2	DOID:5082 (is_implicated_in)
Disease	blood osmolality measurement	TEAD1 NFAT5	1.70e-03	58	31	2	EFO_0007967
Disease	rheumatoid arthritis, ACPA-positive rheumatoid arthritis, rheumatoid factor seropositivity measurement	C5 CBFA2T3	2.00e-03	63	31	2	EFO_0000685, EFO_0007791, EFO_0009459

Protein segments in the cluster

Peptide	Gene	Start	Entry
QPWMGSAAMAASSVS	ATP7B	1351	P35670
PWMGSAAMAASSVSV	ATP7A	1386	Q04656
VARSNSWMGSQGPMS	RBMY1A1	171	P0DJD3
VARSNSWMGSQGPMS	RBMY1B	171	A6NDE4
VARSNSWMGSQGPMS	RBMY1C	171	P0DJD4
VARSNSWMGSQGPMS	RBMY1D	171	P0C7P1
VARSNSWMGSQGPMS	RBMY1E	171	A6NEQ0
VARSNSWMGSQGPMS	RBMY1F	171	Q15415
SWMTDTMAPSADSRV	OLFM2	216	O95897
DPTAWATAMNNLGMA	ENOX2	36	Q16206
MWNTGSTYNLSSGMA	CARM1	496	Q86X55
GVTSMPSSMWSGQAS	MTSS1	656	O43312
VVMTSMGQATWSDPH	DCXR	181	Q7Z4W1
TGSSSLWNLMGNAMV	LMAN2L	66	Q9H0V9
WSMVCLLMNGSSHSP	CBFA2T3	121	O75081
SCSMWMEDSPSNFSN	NFAT5	171	O94916
MSDSLWTALSNFSMP	MAST1	1	Q9Y2H9
RAYQMGWTPNMSAAS	FBXL17	686	Q9UF56
NMATGMDSWVALAAV	C5	591	P01031
LQNRSGAMSPMSWNS	FADD	186	Q13158
GAMSPMSWNSDASTS	FADD	191	Q13158
GSRSNGMWAHSMTVQ	ATE1	31	O95260
ASSVMVARAAMWNPS	DUS2	236	Q9NX74
MAPWASGSRFMDTSA	MFNG	211	O00587
SPWSISSTMAMVYMG	SERPINB2	31	P05120
PSASGMGTTHWNQML	SYT12	391	Q8IV01
VGMMSSSTLWGNISD	SVOP	131	Q8N4V2
AMMAAAQAALQSSWG	TARDBP	321	Q13148
DNVGTWMLTSMNSSP	F5	656	P12259
ATEASQWHRMMTGGN	PLEKHA4	681	Q9H4M7
QWSSIMAGSLAGMVS	SLC25A43	106	Q8WUT9
MAAAWMAPAQESVTF	ZNF460	1	Q14592
LGSTSSVSVGPAWMM	SGSM1	436	Q2NKQ1
SHGGSTMSLWEVMQS	PLEC	3716	Q15149
LNADSCSSPQMGAMW	ZNF75D	6	P51815
CSSPQMGAMWETSGS	ZNF75D	11	P51815
SAPQCWAQMASGSFM	VSIG10	226	Q8N0Z9
WSGSESPAENMERMS	TEAD1	6	P28347
SWLLATPQASATSMM	GARIN5B	721	Q8N5Q1