Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	aminoacyltransferase activity	RNF123 HUWE1 HECTD3 KLHL20 EPB42 FBXW11	1.17e-03	532	45	6	GO:0016755
GeneOntologyMolecularFunction	acyltransferase activity	RNF123 KAT2A HUWE1 HECTD3 KLHL20 EPB42 FBXW11	1.62e-03	775	45	7	GO:0016746
GeneOntologyBiologicalProcess	ubiquitin-dependent protein catabolic process	RNF123 HSPBP1 FBXL16 HUWE1 HECTD3 PTK2 KLHL20 FBXW11	6.43e-05	640	45	8	GO:0006511
GeneOntologyBiologicalProcess	modification-dependent protein catabolic process	RNF123 HSPBP1 FBXL16 HUWE1 HECTD3 PTK2 KLHL20 FBXW11	7.24e-05	651	45	8	GO:0019941
GeneOntologyBiologicalProcess	modification-dependent macromolecule catabolic process	RNF123 HSPBP1 FBXL16 HUWE1 HECTD3 PTK2 KLHL20 FBXW11	7.64e-05	656	45	8	GO:0043632
GeneOntologyBiologicalProcess	negative regulation of cellular component organization	RHPN1 FHOD3 ADAM17 PRKCZ KAT2A HUWE1 TNR CEP97 PTK2	8.68e-05	864	45	9	GO:0051129
GeneOntologyCellularComponent	microtubule organizing center	RABEP2 FAM184A HAUS4 PRKCZ KAT2A DYNLT4 CEP97 PTK2 HAUS5 FBXW11	2.02e-05	919	45	10	GO:0005815
GeneOntologyCellularComponent	HAUS complex	HAUS4 HAUS5	1.26e-04	8	45	2	GO:0070652
GeneOntologyCellularComponent	centrosome	RABEP2 FAM184A HAUS4 KAT2A CEP97 PTK2 HAUS5 FBXW11	2.10e-04	770	45	8	GO:0005813
GeneOntologyCellularComponent	microtubule associated complex	HAUS4 DYNLT4 HAUS5 FBXW11	3.95e-04	161	45	4	GO:0005875
GeneOntologyCellularComponent	mitotic spindle microtubule	HAUS4 HAUS5	4.06e-04	14	45	2	GO:1990498
GeneOntologyCellularComponent	actin cytoskeleton	FHOD3 ADAM17 PRKCZ MYO1H PTK2 KLHL20	1.39e-03	576	45	6	GO:0015629
Domain	HECT	HUWE1 HECTD3	1.83e-03	27	44	2	PF00632
Domain	HECTc	HUWE1 HECTD3	1.83e-03	27	44	2	SM00119
Domain	HECT_dom	HUWE1 HECTD3	1.83e-03	27	44	2	IPR000569
Domain	HECT	HUWE1 HECTD3	1.83e-03	27	44	2	PS50237
Domain	ARM-like	FHOD3 HSPBP1 HUWE1 ARMC12	3.68e-03	270	44	4	IPR011989
Domain	Leu-rich_rpt	FBXL16 LRRC28 CEP97 TONSL	3.73e-03	271	44	4	IPR001611
Domain	ARM_REPEAT	HSPBP1 ARMC12	4.00e-03	40	44	2	PS50176
Domain	-	FBXL16 LRRC28 CEP97 TONSL	6.77e-03	321	44	4	3.80.10.10
Domain	L_dom-like	FBXL16 LRRC28 CEP97 TONSL	7.30e-03	328	44	4	IPR032675
Domain	LRR_6	FBXL16 TONSL	7.44e-03	55	44	2	PF13516
Domain	ARM-type_fold	FHOD3 HSPBP1 HUWE1 ARMC12	8.18e-03	339	44	4	IPR016024
Domain	EGF_extracell	TNR STAB1	8.80e-03	60	44	2	IPR013111
Domain	EGF_2	TNR STAB1	8.80e-03	60	44	2	PF07974
Pathway	REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION	RNF123 FBXL16 HUWE1 HECTD3 KLHL20 FBXW11	4.08e-05	299	31	6	MM15711
Pathway	REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION	RNF123 FBXL16 HUWE1 HECTD3 KLHL20 FBXW11	4.81e-05	308	31	6	M1070
Pathway	REACTOME_CLASS_I_MHC_MEDIATED_ANTIGEN_PROCESSING_PRESENTATION	RNF123 FBXL16 HUWE1 HECTD3 KLHL20 FBXW11	8.74e-05	343	31	6	MM15712
Pathway	REACTOME_CLASS_I_MHC_MEDIATED_ANTIGEN_PROCESSING_PRESENTATION	RNF123 FBXL16 HUWE1 HECTD3 KLHL20 FBXW11	1.56e-04	381	31	6	M1066
Pubmed	Regulation of profibrotic responses by ADAM17 activation in high glucose requires its C-terminus and FAK.	ADAM17 PTK2	1.64e-06	2	45	2	29361535
Pubmed	Cytosolic quality control of mislocalized proteins requires RNF126 recruitment to Bag6.	RNF123 HUWE1 HECTD3	3.06e-06	22	45	3	24981174
Pubmed	A directed protein interaction network for investigating intracellular signal transduction.	PLEKHJ1 CPNE6 PRKCZ FBXL16 KMT2B PTK2 HAUS5 FBXW11 TONSL	1.16e-05	1124	45	9	21900206
Pubmed	Isoform-specific contribution of protein kinase C to prion processing.	ADAM17 PRKCZ	2.45e-05	6	45	2	18722532
Pubmed	Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.	NUP98 SMC4 HAUS4 HUWE1 CEP97 CHAF1A	3.04e-05	469	45	6	27634302
Pubmed	Large-scale mapping of human protein-protein interactions by mass spectrometry.	NUP98 SMC4 PLEKHJ1 RNF123 KRT82 PTK2 CHAF1A FBXW11 TONSL	3.31e-05	1284	45	9	17353931
Pubmed	Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods.	HAUS4 CEP97 HAUS5 FBXW11	3.88e-05	146	45	4	21399614
Pubmed	HAUS, the 8-subunit human Augmin complex, regulates centrosome and spindle integrity.	HAUS4 HAUS5	4.56e-05	8	45	2	19427217
Pubmed	The HAUS Complex Is a Key Regulator of Non-centrosomal Microtubule Organization during Neuronal Development.	HAUS4 HAUS5	4.56e-05	8	45	2	30044976
Pubmed	The augmin complex plays a critical role in spindle microtubule generation for mitotic progression and cytokinesis in human cells.	HAUS4 HAUS5	8.94e-05	11	45	2	19369198
Pubmed	The microtubule-associated protein EML3 regulates mitotic spindle assembly by recruiting the Augmin complex to spindle microtubules.	HAUS4 HAUS5	8.94e-05	11	45	2	30723163
Pubmed	Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells.	NUP98 SMC4 CHPF2 ADAM17 HUWE1 ABCF3	1.33e-04	613	45	6	22268729
Pubmed	The deubiquitinase TRABID stabilizes the K29/K48-specific E3 ubiquitin ligase HECTD1.	RABEP2 HECTD3 HAUS5 FBXW11	1.64e-04	212	45	4	33853758
Pubmed	Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes.	HAUS4 HSPBP1 HUWE1 CHAF1A HAUS5 TONSL	1.75e-04	645	45	6	25281560
Pubmed	PTENα and PTENβ promote carcinogenesis through WDR5 and H3K4 trimethylation.	SMC4 HSPBP1 CEP97 FBXW11	1.80e-04	217	45	4	31685992
Pubmed	Maturation of human dendritic cells is accompanied by functional remodelling of the ubiquitin-proteasome system.	FBXL16 HUWE1 FBXW11	1.86e-04	85	45	3	19028597
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	NUP98 SMC4 CHPF2 HSPBP1 HUWE1 HECTD3 CEP97	1.93e-04	942	45	7	31073040
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	HUWE1 KMT2B FBXW11	1.99e-04	87	45	3	12465718
Pubmed	Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity.	RNF123 HUWE1 HECTD3	2.58e-04	95	45	3	29643511
Pubmed	Genomic analysis of mouse retinal development.	NUP98 RHPN1 KMT2B MYO1H PTK2 TONSL STAB1	2.88e-04	1006	45	7	15226823
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	SMC4 PCDHA5 RNF123 HUWE1 KMT2B TNR	3.55e-04	736	45	6	29676528
Pubmed	A high-throughput approach for measuring temporal changes in the interactome.	NUP98 SMC4 RABEP2 RNF123 HSPBP1 HUWE1 ABCF3 HECTD3	4.99e-04	1455	45	8	22863883
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	TXNRD3 RHPN1 HAUS4 KAT2A HUWE1 KMT2B CEP170B	5.07e-04	1105	45	7	35748872
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	CHPF2 ADAM17 KAT2A HECTD3 CEP170B CHAF1A HAUS5	5.37e-04	1116	45	7	31753913
Pubmed	Cullin-3-KCTD10-mediated CEP97 degradation promotes primary cilium formation.	CEP97 KLHL20	5.63e-04	27	45	2	30404837
Pubmed	Cul3-KLHL20 E3 ubiquitin ligase plays a key role in the arms race between HIV-1 Nef and host SERINC5 restriction.	HUWE1 KLHL20	6.06e-04	28	45	2	35474067
Pubmed	Rebalancing gene haploinsufficiency in vivo by targeting chromatin.	PRKCZ KMT2B	6.06e-04	28	45	2	27256596
Pubmed	Rho signalling restriction by the RhoGAP Stard13 integrates growth and morphogenesis in the pancreas.	PRKCZ PTK2	6.96e-04	30	45	2	23175628
Pubmed	The human cytoplasmic dynein interactome reveals novel activators of motility.	PIK3AP1 FAM184A HAUS4 CEP97 CEP170B HAUS5	7.71e-04	853	45	6	28718761
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	NUP98 SMC4 HUWE1 ABCF3 CHAF1A FBXW11	7.90e-04	857	45	6	25609649
Pubmed	The AAA-ATPase ATAD1 and its partners promote degradation of desmin intermediate filaments in muscle.	RNF123 HUWE1	7.92e-04	32	45	2	36278411
Pubmed	TRIP12 promotes small-molecule-induced degradation through K29/K48-branched ubiquitin chains.	HUWE1 CHAF1A	8.43e-04	33	45	2	33567268
Pubmed	Disease-associated KBTBD4 mutations in medulloblastoma elicit neomorphic ubiquitylation activity to promote CoREST degradation.	HSPBP1 HUWE1	1.00e-03	36	45	2	35379950
Pubmed	Cdc42 controls progenitor cell differentiation and beta-catenin turnover in skin.	PRKCZ KRT82	1.18e-03	39	45	2	16510873
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	RNF123 FBXL16 HUWE1 CCDC24 PTK2 FBXW11 STAB1	1.23e-03	1285	45	7	35914814
Pubmed	ALS/FTD-causing mutation in cyclin F causes the dysregulation of SFPQ.	SMC4 RABEP2 HUWE1 FBXW11 TONSL	1.24e-03	624	45	5	33729478
Pubmed	DCAF8, a novel MuRF1 interaction partner, promotes muscle atrophy.	TXNRD3 RHPN1 KMT2B TNR	1.25e-03	364	45	4	31391242
Interaction	UBXN6 interactions	TXNRD3 SMC4 ABCF3 PTER HECTD3 CEP97 HAUS5 TONSL	5.38e-07	325	45	8	int:UBXN6
Interaction	RFXANK interactions	SMC4 HUWE1 ABCF3 CEP97 HAUS5 TONSL	8.42e-07	146	45	6	int:RFXANK
Interaction	DHFR interactions	HAUS4 RNF123 HUWE1 ABCF3 HAUS5	2.19e-05	152	45	5	int:DHFR
Interaction	PCDHA5 interactions	PCDHA5 RNF123	2.92e-05	4	45	2	int:PCDHA5
Cytoband	1p34.1	CCDC24 DYNLT4 HECTD3	2.48e-05	57	45	3	1p34.1
Cytoband	8q24.3	RHPN1 PTK2 TONSL	1.91e-04	113	45	3	8q24.3
Cytoband	Ensembl 112 genes in cytogenetic band chr1p34	CCDC24 DYNLT4 HECTD3	3.02e-03	294	45	3	chr1p34
GeneFamily	HAUS augmin like complex	HAUS4 HAUS5	6.91e-05	8	29	2	581
ToppCell	PND14-Immune-Immune_Myeloid-Monocytic-Macrophage-IM-IM_prolif\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	HAUS4 CHAF1A HAUS5 TONSL STAB1	8.08e-07	171	45	5	bf475a69db04d4a886e442704955c6a96ff0de46
ToppCell	MS-CD8-antiviral_CD4\|MS / Condition, Cell_class and T cell subcluster	RABEP2 CHPF2 HAUS4 PTER HECTD3	1.36e-06	190	45	5	8c831c4560b8e70f92b4c15644fea39f7f7afcf2
ToppCell	Bronchial-NucSeq-Epithelial-Epi_airway_secretory-Secretory_Club\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	RHPN1 FBXL16 HAL PTK2 EPB42	1.58e-06	196	45	5	ed76eeb37400ca154feae9b7ebaddb6c434f8b81
ToppCell	droplet-Lung-immune-endo-depleted-3m-Lymphocytic-Proliferating_NK\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RHPN1 FHOD3 CHAF1A TONSL	2.66e-05	171	45	4	1eebd7138c3b20ddc1104f21615f9df0e776bbe6
ToppCell	CV-Severe-7\|CV / Virus stimulation, Condition and Cluster	NUP98 ADAM17 HUWE1 CEP170B	2.97e-05	176	45	4	3de0c7d77210049e5616db21eed1490a17a5ec2d
ToppCell	cellseq2-Epithelial-Epithelial_Alveolar-AT2-AT2\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	NUP98 SMC4 RNF123 CEP97	4.35e-05	194	45	4	df835578d86a49ae5af5632152fbab9548c0a448
ToppCell	cellseq2-Epithelial-Epithelial_Alveolar\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	NUP98 SMC4 RNF123 CEP97	4.35e-05	194	45	4	0715f2d55f4a6d2edda1b3dc52f12d25ce59eb10
ToppCell	cellseq2-Epithelial-Epithelial_Alveolar-AT2\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	NUP98 SMC4 RNF123 CEP97	4.35e-05	194	45	4	a4f7cd507eba40985d82635bbae28c7f5703f883
ToppCell	Parenchymal-10x3prime_v2-Epithelial-Epi_alveolar-Dividing_AT2\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	TRPV3 FAM184A CEP170B CHAF1A	4.89e-05	200	45	4	befc25cbcbac2c02e5fd33d6e78e59979050090c
Drug	SB-3CT	ADAM17 KRT82 PTK2	2.04e-06	13	45	3	CID009883002
Drug	Pantothenic acid calcium salt monohydrate [63409-48-3]; Down 200; 8uM; HL60; HT_HG-U133A	ADAM17 KAT2A PTK2 KLHL20 HAUS5 FBXW11	2.39e-06	197	45	6	1311_DN
Drug	helium;dihydroiodide	SMC4 PTK2 TONSL	1.24e-05	23	45	3	CID000437954
Disease	atopic dermatitis (implicated_via_orthology)	TRPV3 ADAM17	1.19e-04	11	44	2	DOID:3310 (implicated_via_orthology)
Disease	vitamin D measurement, COVID-19	HAL CEP97	2.44e-03	49	44	2	EFO_0004631, MONDO_0100096
Disease	left ventricular diastolic function measurement	FHOD3 PTK2	2.96e-03	54	44	2	EFO_0008204
Disease	feeling miserable measurement	MYO1H KLHL20	6.23e-03	79	44	2	EFO_0009598
Disease	multisite chronic pain	RNF123 PTK2	8.89e-03	95	44	2	EFO_0010100
Disease	Tinnitus, wellbeing measurement	FHOD3 PTK2	9.07e-03	96	44	2	EFO_0007869, HP_0000360
Disease	neuroticism measurement, cognitive function measurement	PCDHA5 TNR MYO1H STAB1	9.92e-03	566	44	4	EFO_0007660, EFO_0008354

Protein segments in the cluster

Peptide	Gene	Start	Entry
CVISILGRGLIHRER	EPB42	621	P16452
RSCIGRRIAELEIHL	CYP27C1	486	Q4G0S4
ILVSHDERFIRLVCR	ABCF3	661	Q9NUQ8
HRLPRELIFVGREEC	CEP170B	16	Q9Y4F5
KVIIREFQEHCRRGL	CHAF1A	751	Q13111
HRVVRLLCGVRDSEE	PIK3AP1	96	Q6ZUJ8
ICRITDLQEELRHRE	FAM184A	866	Q8NB25
ICIARLAVERERHGR	ARMC12	51	Q5T9G4
LLEHGVCEEVERVRR	POLM	216	Q9NP87
RVELRVSCHGLLDRD	CPNE6	21	O95741
EHGAERLRIEIVTLR	RABEP2	436	Q9H5N1
RLEERRGIIEFHVIG	KAT2A	491	Q92830
GIREKAVRELLTRHC	NUP98	1576	P52948
ARLVRELCEQVHVRL	DYNLT4	146	Q5JR98
LRVLEGHEELVRCIR	FBXW11	436	Q9UKB1
HIVIFALRRILRGEE	KMT2B	2671	Q9UMN6
RRLLEGEEHRLCEGI	KRT82	421	Q9NSB4
RELLRCLEEEVRHLP	HAUS5	441	O94927
RRRAECSIHLEVIVD	PCDHA5	96	Q9Y5H7
ILCHILRGEPVIRER	HUWE1	1276	Q7Z6Z7
KRIRRVRLLVEEGCE	PTER	276	Q96BW5
VRLLVEEGCEDRILV	PTER	281	Q96BW5
HELAAISERRIERLC	HAL	461	P42357
LRKHRELCDVVLVVG	KLHL20	61	Q9Y2M5
HIVCLTDEIRRLRKE	CEP97	596	Q8IW35
DCAERIIILKIVHRR	FHOD3	1201	Q2V2M9
VEVHRLIRDRLEGAI	HAUS4	296	Q9H6D7
RGLLEEECHTLEREI	CCDC24	166	Q8N4L8
LHRLEELVLDRCVRI	FBXL16	371	Q8N461
REPELGLEELLRHRC	HSPBP1	311	Q9NZL4
EIVCPEIGRLRALRH	LRRC28	101	Q86X40
EIQRERIELGRCIGE	PTK2	416	Q05397
VGALLLERCRVVREE	PLEKHJ1	56	Q9NW61
LRLHALCRVLREVDL	RHPN1	421	Q8TCX5
RVLAHIRDDDVIIRI	ADAM17	126	P78536
LDLLLECVTQRGHRR	CHPF2	446	Q9P2E5
LLRVCLRTIEHGDRT	RNF123	841	Q5XPI4
TLLHRACIEGQLRRV	TONSL	531	Q96HA7
VRGREESERICTLVH	TNR	936	Q92752
CRRVEILNEHRGEKL	SMC4	271	Q9NTJ3
HVVGCRRLRSEDLLE	STAB1	1646	Q9NY15
AREELRRHLVGLIER	TXNRD3	51	Q86VQ6
VELLVELQELCRRRH	TRPV3	136	Q8NET8
IRIVECRDDGIDVRL	HECTD3	351	Q5T447
RLARQCRDEGLIIHV	PRKCZ	81	Q05513
RHKGIISILDEECIR	MYO1H	456	Q8N1T3