Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	voltage-gated chloride channel activity	CLCN3 CLCN5 CLCN7	6.67e-06	11	70	3	GO:0005247
GeneOntologyMolecularFunction	snRNP binding	LEMD3 RBM23 SNRPN	2.24e-05	16	70	3	GO:0070990
GeneOntologyMolecularFunction	voltage-gated monoatomic anion channel activity	CLCN3 CLCN5 CLCN7	2.71e-05	17	70	3	GO:0008308
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	FOXE1 SOX3 FOXO1 KAT2B OTX1 FOXQ1 NACC2 MTF1 HMX3 ARX DMRTA2 E4F1 ZNF865 FOXK1 KDM1A	1.32e-04	1459	70	15	GO:0000977
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	FOXE1 SOX3 FOXO1 OTX1 FOXQ1 NACC2 MTF1 ARX DMRTA2 E4F1 ZNF865 FOXK1 KDM1A	3.40e-04	1244	70	13	GO:0000978
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	FOXE1 SOX3 FOXO1 OTX1 FOXQ1 NACC2 MTF1 ARX DMRTA2 E4F1 ZNF865 FOXK1 KDM1A	4.18e-04	1271	70	13	GO:0000987
GeneOntologyMolecularFunction	phosphatidylinositol 3-kinase activator activity	PRKD1 IRS2	4.29e-04	9	70	2	GO:0141038
GeneOntologyMolecularFunction	secondary active transmembrane transporter activity	SLC25A22 CLCN3 SLC12A2 CLCN5 CLCN7 SLC25A31	5.97e-04	296	70	6	GO:0015291
GeneOntologyMolecularFunction	U1 snRNP binding	LEMD3 RBM23	7.82e-04	12	70	2	GO:1990446
GeneOntologyMolecularFunction	DNA-binding transcription repressor activity, RNA polymerase II-specific	FOXO1 FOXQ1 NACC2 ARX E4F1 FOXK1	8.96e-04	320	70	6	GO:0001227
GeneOntologyMolecularFunction	chloride transmembrane transporter activity	CLCN3 SLC12A2 CLCN5 CLCN7	9.75e-04	125	70	4	GO:0015108
GeneOntologyMolecularFunction	DNA-binding transcription repressor activity	FOXO1 FOXQ1 NACC2 ARX E4F1 FOXK1	9.86e-04	326	70	6	GO:0001217
GeneOntologyMolecularFunction	histone H3K9 demethylase activity	KDM7A KDM1A	1.07e-03	14	70	2	GO:0032454
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	FOXE1 SOX3 FOXO1 ATMIN OTX1 FOXQ1 NACC2 MTF1 HMX3 ARX DMRTA2 E4F1 FOXK1	1.12e-03	1412	70	13	GO:0000981
GeneOntologyMolecularFunction	antiporter activity	CLCN3 CLCN5 CLCN7 SLC25A31	1.41e-03	138	70	4	GO:0015297
GeneOntologyMolecularFunction	phosphatidylinositol 3-kinase regulator activity	PRKD1 IRS2	1.79e-03	18	70	2	GO:0035014
GeneOntologyMolecularFunction	monoatomic anion transmembrane transporter activity	CLCN3 SLC12A2 CLCN5 CLCN7	1.96e-03	151	70	4	GO:0008509
GeneOntologyMolecularFunction	sequence-specific mRNA binding	RBM24 NOVA2	1.99e-03	19	70	2	GO:1990825
GeneOntologyMolecularFunction	inorganic anion transmembrane transporter activity	CLCN3 SLC12A2 CLCN5 CLCN7	3.07e-03	171	70	4	GO:0015103
GeneOntologyMolecularFunction	DNA-binding transcription activator activity, RNA polymerase II-specific	SOX3 FOXO1 ATMIN OTX1 MTF1 ARX E4F1	3.42e-03	560	70	7	GO:0001228
GeneOntologyMolecularFunction	chloride channel activity	CLCN3 CLCN5 CLCN7	3.43e-03	86	70	3	GO:0005254
GeneOntologyMolecularFunction	DNA-binding transcription activator activity	SOX3 FOXO1 ATMIN OTX1 MTF1 ARX E4F1	3.63e-03	566	70	7	GO:0001216
GeneOntologyMolecularFunction	voltage-gated monoatomic ion channel activity	CLCN3 CLCN5 CLCN7 KCNS1	3.83e-03	182	70	4	GO:0005244
GeneOntologyMolecularFunction	voltage-gated channel activity	CLCN3 CLCN5 CLCN7 KCNS1	3.99e-03	184	70	4	GO:0022832
GeneOntologyBiologicalProcess	regulation of mRNA splicing, via spliceosome	PUF60 RBM42 RBM24 PTBP1 RBM23 NOVA2	5.47e-06	129	71	6	GO:0048024
GeneOntologyBiologicalProcess	regulation of RNA splicing	KAT2B PUF60 RBM42 RBM24 PTBP1 RBM23 NOVA2	7.15e-06	207	71	7	GO:0043484
GeneOntologyBiologicalProcess	regulation of mRNA processing	PUF60 RBM42 RBM24 PTBP1 RBM23 NOVA2	1.74e-05	158	71	6	GO:0050684
GeneOntologyBiologicalProcess	regulation of secretory granule organization	OSBP PTBP1	3.50e-05	3	71	2	GO:1904409
GeneOntologyBiologicalProcess	positive regulation of secretory granule organization	OSBP PTBP1	3.50e-05	3	71	2	GO:1904411
GeneOntologyBiologicalProcess	regulation of alternative mRNA splicing, via spliceosome	PUF60 RBM24 PTBP1 NOVA2	5.08e-05	59	71	4	GO:0000381
GeneOntologyBiologicalProcess	regulation of cellular component size	CLCN3 SLC12A2 PUM2 ESAM CDHR5 PRKD1 ELN KDM1A	1.06e-04	426	71	8	GO:0032535
GeneOntologyBiologicalProcess	synaptic vesicle coating	AP3S1 AP3S2	1.16e-04	5	71	2	GO:0016183
GeneOntologyBiologicalProcess	regulation of mRNA metabolic process	PUF60 RBM42 PUM2 RBM24 PTBP1 RBM23 TENT5B NOVA2	1.38e-04	443	71	8	GO:1903311
GeneOntologyBiologicalProcess	secretory granule organization	OSBP AP3S1 PTBP1 AP3S2	1.52e-04	78	71	4	GO:0033363
GeneOntologyBiologicalProcess	alternative mRNA splicing, via spliceosome	PUF60 RBM24 PTBP1 NOVA2	1.59e-04	79	71	4	GO:0000380
GeneOntologyBiologicalProcess	central nervous system development	SOX3 OTX1 NUMBL MTF1 HMX3 ARX DMRTA2 CRTAC1 IRS2 KDM7A KDM1A NOVA2 MSI2	1.98e-04	1197	71	13	GO:0007417
GeneOntologyBiologicalProcess	mRNA splicing, via spliceosome	PUF60 RBM42 RBM24 PTBP1 RBM23 SNRPN NOVA2	2.29e-04	358	71	7	GO:0000398
GeneOntologyBiologicalProcess	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	PUF60 RBM42 RBM24 PTBP1 RBM23 SNRPN NOVA2	2.29e-04	358	71	7	GO:0000377
GeneOntologyBiologicalProcess	clathrin-coated vesicle cargo loading	AP3S1 AP3S2	2.43e-04	7	71	2	GO:0035652
GeneOntologyBiologicalProcess	clathrin-coated vesicle cargo loading, AP-3-mediated	AP3S1 AP3S2	2.43e-04	7	71	2	GO:0035654
GeneOntologyBiologicalProcess	RNA splicing, via transesterification reactions	PUF60 RBM42 RBM24 PTBP1 RBM23 SNRPN NOVA2	2.45e-04	362	71	7	GO:0000375
GeneOntologyBiologicalProcess	regulation of anatomical structure size	KAT2B CLCN3 SLC12A2 PUM2 ESAM CDHR5 PRKD1 ELN KDM1A	2.61e-04	618	71	9	GO:0090066
GeneOntologyBiologicalProcess	diencephalon development	SOX3 OTX1 ARX KDM1A	2.63e-04	90	71	4	GO:0021536
GeneOntologyBiologicalProcess	RNA splicing	KAT2B PUF60 RBM42 RBM24 PTBP1 RBM23 SNRPN NOVA2	3.23e-04	502	71	8	GO:0008380
GeneOntologyBiologicalProcess	axon development	PLEKHG4B HMCN2 NUMBL CSPG5 ARX PUM2 CRTAC1 PIP5K1C NOVA2	3.45e-04	642	71	9	GO:0061564
GeneOntologyBiologicalProcess	regulation of peptide hormone secretion	FOXO1 SLC25A22 OSBP PRKD1 IRS2 PTBP1	3.83e-04	277	71	6	GO:0090276
GeneOntologyBiologicalProcess	neuron projection development	PLEKHG4B KAT2B HMCN2 NUMBL CSPG5 ARX PUM2 CRTAC1 PRKD1 PTBP1 PIP5K1C KDM1A NOVA2	3.94e-04	1285	71	13	GO:0031175
GeneOntologyBiologicalProcess	maintenance of blood-brain barrier	SLC12A2 ESAM CDH5	4.08e-04	42	71	3	GO:0035633
GeneOntologyBiologicalProcess	regulation of peptide transport	FOXO1 SLC25A22 OSBP PRKD1 IRS2 PTBP1	4.21e-04	282	71	6	GO:0090087
GeneOntologyBiologicalProcess	regulation of peptide secretion	FOXO1 SLC25A22 OSBP PRKD1 IRS2 PTBP1	4.21e-04	282	71	6	GO:0002791
GeneOntologyBiologicalProcess	transepithelial chloride transport	SLC12A2 CLCN7	5.16e-04	10	71	2	GO:0030321
GeneOntologyBiologicalProcess	protein demethylation	KDM7A KDM1A	5.16e-04	10	71	2	GO:0006482
GeneOntologyBiologicalProcess	protein dealkylation	KDM7A KDM1A	5.16e-04	10	71	2	GO:0008214
GeneOntologyBiologicalProcess	chloride transmembrane transport	CLCN3 SLC12A2 CLCN5 CLCN7	6.05e-04	112	71	4	GO:1902476
GeneOntologyBiologicalProcess	synaptic vesicle budding from presynaptic endocytic zone membrane	AP3S1 AP3S2	6.30e-04	11	71	2	GO:0016185
GeneOntologyBiologicalProcess	negative regulation of mRNA metabolic process	RBM42 RBM24 PTBP1 TENT5B	6.68e-04	115	71	4	GO:1903312
GeneOntologyBiologicalProcess	brain development	SOX3 OTX1 NUMBL HMX3 ARX DMRTA2 CRTAC1 IRS2 KDM7A KDM1A	6.88e-04	859	71	10	GO:0007420
GeneOntologyBiologicalProcess	negative regulation of transcription by RNA polymerase II	RTF1 FOXE1 SOX3 FOXO1 KAT2B FOXQ1 NACC2 ARX E4F1 FOXK1 KDM1A	8.94e-04	1053	71	11	GO:0000122
Domain	Cl-channel_core	CLCN3 CLCN5 CLCN7	4.17e-06	9	70	3	IPR014743
Domain	-	CLCN3 CLCN5 CLCN7	4.17e-06	9	70	3	1.10.3080.10
Domain	Voltage_CLC	CLCN3 CLCN5 CLCN7	4.17e-06	9	70	3	PF00654
Domain	Cl-channel_volt-gated	CLCN3 CLCN5 CLCN7	4.17e-06	9	70	3	IPR001807
Domain	TF_fork_head_CS_2	FOXE1 FOXO1 FOXQ1 FOXK1	2.62e-05	46	70	4	IPR030456
Domain	CBS	CLCN3 CLCN5 CLCN7	2.73e-05	16	70	3	SM00116
Domain	TF_fork_head_CS_1	FOXE1 FOXO1 FOXQ1 FOXK1	2.86e-05	47	70	4	IPR018122
Domain	FH	FOXE1 FOXO1 FOXQ1 FOXK1	3.38e-05	49	70	4	SM00339
Domain	FORK_HEAD_1	FOXE1 FOXO1 FOXQ1 FOXK1	3.38e-05	49	70	4	PS00657
Domain	FORK_HEAD_2	FOXE1 FOXO1 FOXQ1 FOXK1	3.38e-05	49	70	4	PS00658
Domain	Fork_head_dom	FOXE1 FOXO1 FOXQ1 FOXK1	3.38e-05	49	70	4	IPR001766
Domain	FORK_HEAD_3	FOXE1 FOXO1 FOXQ1 FOXK1	3.38e-05	49	70	4	PS50039
Domain	Forkhead	FOXE1 FOXO1 FOXQ1 FOXK1	3.38e-05	49	70	4	PF00250
Domain	-	LEMD3 PUF60 RBM42 RBM24 PTBP1 RBM23 MSI2	3.55e-05	244	70	7	3.30.70.330
Domain	Nucleotide-bd_a/b_plait	LEMD3 PUF60 RBM42 RBM24 PTBP1 RBM23 MSI2	5.05e-05	258	70	7	IPR012677
Domain	CBS_dom	CLCN3 CLCN5 CLCN7	5.49e-05	20	70	3	IPR000644
Domain	CBS	CLCN3 CLCN5 CLCN7	5.49e-05	20	70	3	PF00571
Domain	CBS	CLCN3 CLCN5 CLCN7	5.49e-05	20	70	3	PS51371
Domain	RRM_1	PUF60 RBM42 RBM24 PTBP1 RBM23 MSI2	1.29e-04	208	70	6	PF00076
Domain	RRM	PUF60 RBM42 RBM24 PTBP1 RBM23 MSI2	1.62e-04	217	70	6	SM00360
Domain	RRM_dom	PUF60 RBM42 RBM24 PTBP1 RBM23 MSI2	2.07e-04	227	70	6	IPR000504
Domain	RRM	PUF60 RBM42 RBM24 PTBP1 RBM23 MSI2	2.22e-04	230	70	6	PS50102
Domain	AP_complex_ssu	AP3S1 AP3S2	2.87e-04	7	70	2	IPR016635
Domain	BEN	NACC2 BANP	4.90e-04	9	70	2	PF10523
Domain	CLAT_ADAPTOR_S	AP3S1 AP3S2	4.90e-04	9	70	2	PS00989
Domain	BEN_domain	NACC2 BANP	4.90e-04	9	70	2	IPR018379
Domain	BEN	NACC2 BANP	4.90e-04	9	70	2	PS51457
Domain	BEN	NACC2 BANP	4.90e-04	9	70	2	SM01025
Domain	Clathrin_sm-chain_CS	AP3S1 AP3S2	8.92e-04	12	70	2	IPR000804
Domain	-	FOXE1 FOXO1 FOXQ1 FOXK1 KDM1A	1.35e-03	218	70	5	1.10.10.10
Domain	AP_mu_sigma_su	AP3S1 AP3S2	1.61e-03	16	70	2	IPR022775
Domain	Clat_adaptor_s	AP3S1 AP3S2	1.61e-03	16	70	2	PF01217
Domain	WHTH_DNA-bd_dom	FOXE1 FOXO1 FOXQ1 FOXK1 KDM1A	2.14e-03	242	70	5	IPR011991
Domain	-	PLEKHG4B IQSEC3 OSBP NUMBL PRKD1 IRS2	3.44e-03	391	70	6	2.30.29.30
Domain	PH	PLEKHG4B IQSEC3 OSBP PRKD1 IRS2	3.88e-03	278	70	5	SM00233
Domain	PH_DOMAIN	PLEKHG4B IQSEC3 OSBP PRKD1 IRS2	3.94e-03	279	70	5	PS50003
Domain	PH_domain	PLEKHG4B IQSEC3 OSBP PRKD1 IRS2	4.00e-03	280	70	5	IPR001849
Domain	Longin-like_dom	AP3S1 AP3S2	4.91e-03	28	70	2	IPR011012
Domain	Aden_trnslctor	SLC25A22 SLC25A31	4.91e-03	28	70	2	IPR002113
Domain	PH_dom-like	PLEKHG4B IQSEC3 OSBP NUMBL PRKD1 IRS2	5.21e-03	426	70	6	IPR011993
Domain	Mit_carrier	SLC25A22 SLC25A31	6.39e-03	32	70	2	IPR002067
Pubmed	Chloride and the endosomal-lysosomal pathway: emerging roles of CLC chloride transporters.	CLCN3 CLCN5 CLCN7	3.26e-08	4	71	3	17110406
Pubmed	A census of human transcription factors: function, expression and evolution.	FOXE1 SOX3 FOXO1 OTX1 FOXQ1 MTF1 HMX3 ARX DMRTA2 E4F1 TSC22D2 FOXK1	2.90e-07	908	71	12	19274049
Pubmed	New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules.	LEMD3 HMX3 PUM2 TMEM131 PRKD1 KDM1A SLC25A31 PARP12 MSI2	4.28e-07	462	71	9	31138677
Pubmed	Changing expression of chloride channels during preimplantation mouse development.	CLCN3 CLCN5 CLCN7	6.79e-07	9	71	3	23115349
Pubmed	Ion channel expression in the developing enteric nervous system.	CLCN3 CLCN5 CLCN7 KCNS1	1.00e-06	37	71	4	25798587
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	FOXE1 FOXO1 SMARCA5 FOXQ1 NACC2 PUF60 BANP E4F1 FOXK1 KDM1A NOVA2	1.27e-06	857	71	11	25609649
Pubmed	The Tumor Suppressor CIC Directly Regulates MAPK Pathway Genes via Histone Deacetylation.	CCDC88C SMARCA5 OTX1 DYNC2I2 BANP PTBP1 ZNF865 FOXK1 KDM1A	2.91e-06	583	71	9	29844126
Pubmed	Regulation of oxysterol-binding protein Golgi localization through protein kinase D-mediated phosphorylation.	OSBP PRKD1	4.11e-06	2	71	2	20444975
Pubmed	Chloride/proton antiporters ClC3 and ClC5 support bone formation in mice.	CLCN3 CLCN5	4.11e-06	2	71	2	38666049
Pubmed	The reciprocal stability of FOXO1 and IRS2 creates a regulatory circuit that controls insulin signaling.	FOXO1 IRS2	4.11e-06	2	71	2	16916938
Pubmed	An alternative mechanism of clathrin-coated pit closure revealed by ion conductance microscopy.	CLCN5 CLCN7	1.23e-05	3	71	2	22564416
Pubmed	Loss of the chloride channel ClC-7 leads to lysosomal storage disease and neurodegeneration.	CLCN3 CLCN7	1.23e-05	3	71	2	15706348
Pubmed	Tamoxifen reduces fat mass by boosting reactive oxygen species.	FOXO1 IRS2	1.23e-05	3	71	2	25569103
Pubmed	LPA/PKD-1-FoxO1 Signaling Axis Mediates Endothelial Cell CD36 Transcriptional Repression and Proangiogenic and Proarteriogenic Reprogramming.	FOXO1 PRKD1	1.23e-05	3	71	2	27013613
Pubmed	AP-3: an adaptor-like protein complex with ubiquitous expression.	AP3S1 AP3S2	1.23e-05	3	71	2	9118953
Pubmed	Lysosomal degradation of endocytosed proteins depends on the chloride transport protein ClC-7.	CLCN5 CLCN7	1.23e-05	3	71	2	19661288
Pubmed	Circular RNA SMARCA5 suppressed non-small cell lung cancer progression by regulating miR-670-5p/RBM24 axis.	SMARCA5 RBM24	1.23e-05	3	71	2	33085761
Pubmed	Inactivation of hepatic Foxo1 by insulin signaling is required for adaptive nutrient homeostasis and endocrine growth regulation.	FOXO1 IRS2	1.23e-05	3	71	2	18590693
Pubmed	Support of bone mineral deposition by regulation of pH.	CLCN3 CLCN5	1.23e-05	3	71	2	30044661
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	ATMIN SLC25A22 CCDC88C CLCN7 PUF60 TMEM158 BANP IRS2 PIP5K1C ZNF865 FOXK1	1.42e-05	1105	71	11	35748872
Pubmed	Impact of cytosine methylation on DNA binding specificities of human transcription factors.	FOXE1 SOX3 OTX1 FOXQ1 MTF1 ARX DMRTA2 FOXK1	1.53e-05	544	71	8	28473536
Pubmed	Sox17-mediated expression of adherent molecules is required for the maintenance of undifferentiated hematopoietic cluster formation in midgestation mouse embryos.	ESAM CDH5	2.46e-05	4	71	2	32891959
Pubmed	Interference With ESAM (Endothelial Cell-Selective Adhesion Molecule) Plus Vascular Endothelial-Cadherin Causes Immediate Lethality and Lung-Specific Blood Coagulation.	ESAM CDH5	2.46e-05	4	71	2	31826650
Pubmed	Role of ClC-5 in renal endocytosis is unique among ClC exchangers and does not require PY-motif-dependent ubiquitylation.	CLCN3 CLCN5	2.46e-05	4	71	2	20351103
Pubmed	Alternative Splicing of Cdh23 Exon 68 Is Regulated by RBM24, RBM38, and PTBP1.	RBM24 PTBP1	2.46e-05	4	71	2	32774357
Pubmed	IRS2 signaling in LepR-b neurons suppresses FoxO1 to control energy balance independently of leptin action.	FOXO1 IRS2	2.46e-05	4	71	2	22560222
Pubmed	Foxo1 integrates insulin signaling with mitochondrial function in the liver.	FOXO1 IRS2	2.46e-05	4	71	2	19838201
Pubmed	FoxO1 suppresses Fgf21 during hepatic insulin resistance to impair peripheral glucose utilization and acute cold tolerance.	FOXO1 IRS2	2.46e-05	4	71	2	33761350
Pubmed	P/CAF mediates PAX3-FOXO1-dependent oncogenesis in alveolar rhabdomyosarcoma.	FOXO1 KAT2B	2.46e-05	4	71	2	27453350
Pubmed	Double-negative feedback loop between microRNA-422a and forkhead box (FOX)G1/Q1/E1 regulates hepatocellular carcinoma tumor growth and metastasis.	FOXE1 FOXQ1	2.46e-05	4	71	2	25251503
Pubmed	Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1.	FOXO1 IRS2	2.46e-05	4	71	2	12219087
Pubmed	Specific regulation of the adaptor protein complex AP-3 by the Arf GAP AGAP1.	AP3S1 AP3S2	4.09e-05	5	71	2	12967569
Pubmed	Hepatic p38α MAPK controls gluconeogenesis via FOXO1 phosphorylation at S273 during glucagon signalling in mice.	FOXO1 IRS2	4.09e-05	5	71	2	37202506
Pubmed	Feedback regulation of hepatic gluconeogenesis through modulation of SHP/Nr0b2 gene expression by Sirt1 and FoxO1.	FOXO1 IRS2	4.09e-05	5	71	2	21081708
Pubmed	An essential role for ClC-4 in transferrin receptor function revealed in studies of fibroblasts derived from Clcn4-null mice.	CLCN3 CLCN5	4.09e-05	5	71	2	19339555
Pubmed	The RNA-binding protein Musashi-1 is produced in the developing and adult mouse eye.	PUM2 MSI2	6.13e-05	6	71	2	17768378
Pubmed	New loci associated with central cornea thickness include COL5A1, AKAP13 and AVGR8.	FOXO1 BANP	6.13e-05	6	71	2	20719862
Pubmed	A brain-enriched polypyrimidine tract-binding protein antagonizes the ability of Nova to regulate neuron-specific alternative splicing.	PTBP1 NOVA2	6.13e-05	6	71	2	10829067
Pubmed	Expression of CLCN voltage-gated chloride channel genes in human blood vessels.	CLCN3 CLCN5	6.13e-05	6	71	2	10198195
Pubmed	Inactivating hepatic follistatin alleviates hyperglycemia.	FOXO1 IRS2	6.13e-05	6	71	2	29867232
Pubmed	Genetic analysis of the neuronal and ubiquitous AP-3 adaptor complexes reveals divergent functions in brain.	AP3S1 AP3S2	6.13e-05	6	71	2	15537701
Pubmed	Endothelial adherens junctions control tight junctions by VE-cadherin-mediated upregulation of claudin-5.	FOXO1 CDH5	6.13e-05	6	71	2	18604199
Pubmed	Tagging genes with cassette-exchange sites.	LEMD3 PUM2 TMEM131 KDM7A KDM1A MSI2	6.46e-05	335	71	6	15741177
Pubmed	FoxO1 protects against pancreatic beta cell failure through NeuroD and MafA induction.	FOXO1 IRS2	8.57e-05	7	71	2	16154098
Pubmed	Deletion of ultraconserved elements yields viable mice.	SOX3 ARX	8.57e-05	7	71	2	17803355
Pubmed	Endothelial deletion of PTBP1 disrupts ventricular chamber development.	PTBP1 CDH5	8.57e-05	7	71	2	37002228
Pubmed	RNA Binding Protein Ptbp2 Is Essential for Male Germ Cell Development.	PUM2 PTBP1	8.57e-05	7	71	2	26391954
Pubmed	Characterization of the adaptor-related protein complex, AP-3.	AP3S1 AP3S2	8.57e-05	7	71	2	9151686
Pubmed	The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth.	FOXO1 IRS2	8.57e-05	7	71	2	12488434
Pubmed	OTX2 Transcription Factor Controls Regional Patterning within the Medial Ganglionic Eminence and Regional Identity of the Septum.	OTX1 HMX3 ARX	8.84e-05	42	71	3	26166575
Pubmed	Mechanistic insights into COVID-19 by global analysis of the SARS-CoV-2 3CLpro substrate degradome.	IRS2 TSC22D2 PTBP1	9.49e-05	43	71	3	34672947
Pubmed	An ear-core interaction regulates the recruitment of the AP-3 complex to membranes.	AP3S1 AP3S2	1.14e-04	8	71	2	15469849
Pubmed	Association of the AP-3 adaptor complex with clathrin.	AP3S1 AP3S2	1.14e-04	8	71	2	9545220
Pubmed	The Dlx5 homeobox gene is essential for vestibular morphogenesis in the mouse embryo through a BMP4-mediated pathway.	OTX1 HMX3	1.14e-04	8	71	2	12142028
Pubmed	Cooperative polarization of MCAM/CD146 and ERM family proteins in melanoma.	SLC12A2 CLCN7 NUMBL LEMD3 RELL1 PIP5K1C	1.23e-04	377	71	6	38117590
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	AP3S1 SLC12A2 LEMD3 CLPTM1 BANP PUM2 TMEM131 POC5	1.24e-04	733	71	8	34672954
Pubmed	Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.	RTF1 SLC25A22 SMARCA5 AP3S1 PUF60 YRDC IRS2 PTBP1 SNRPN FOXK1 MSI2	1.32e-04	1415	71	11	28515276
Pubmed	Cross-repressive interactions between Lrig3 and netrin 1 shape the architecture of the inner ear.	OTX1 HMX3	1.47e-04	9	71	2	19004851
Pubmed	Nuclear myosin 1c facilitates the chromatin modifications required to activate rRNA gene transcription and cell cycle progression.	KAT2B SMARCA5	1.47e-04	9	71	2	23555303
Pubmed	Hmx2 homeobox gene control of murine vestibular morphogenesis.	OTX1 HMX3	1.47e-04	9	71	2	11748138
Pubmed	Dlx1&2 and Mash1 transcription factors control striatal patterning and differentiation through parallel and overlapping pathways.	FOXO1 OTX1 HMX3 ARX	1.68e-04	134	71	4	19030180
Pubmed	HIV-1 Vpu inhibits accumulation of the envelope glycoprotein within clathrin-coated, Gag-containing endosomes.	AP3S1 AP3S2	1.83e-04	10	71	2	18076669
Pubmed	Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development.	CLCN3 CLCN5 CLCN7 KCNS1	1.93e-04	139	71	4	16985003
Pubmed	Lack of pendrin expression leads to deafness and expansion of the endolymphatic compartment in inner ears of Foxi1 null mutant mice.	OTX1 HMX3	2.23e-04	11	71	2	12642503
Pubmed	Unbiased Identification of trans Regulators of ADAR and A-to-I RNA Editing.	SMARCA5 PUF60 PTBP1 KDM1A SLC25A31	2.37e-04	271	71	5	32433965
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	SOX3 FOXO1 KAT2B SMARCA5 OTX1 MTF1 FOXK1 PARP12	2.40e-04	808	71	8	20412781
Pubmed	A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.	FOXO1 AP3S1 DYNC2I2 NUMBL IRS2 POC5 FOXK1 PARP12 AP3S2	2.57e-04	1038	71	9	26673895
Pubmed	Functional kinomics establishes a critical node of volume-sensitive cation-Cl- cotransporter regulation in the mammalian brain.	SLC12A2 PRKD1	2.68e-04	12	71	2	27782176
Pubmed	RBM24 is a major regulator of muscle-specific alternative splicing.	NUMBL RBM24	2.68e-04	12	71	2	25313962
Pubmed	A Prox1 enhancer represses haematopoiesis in the lymphatic vasculature.	ESAM CDH5	2.68e-04	12	71	2	36697821
Pubmed	TTF-1/NKX2-1 binds to DDB1 and confers replication stress resistance to lung adenocarcinomas.	SMARCA5 PUF60 PTBP1 KDM1A	2.71e-04	152	71	4	28192407
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	SMARCA5 OTX1 LEMD3 BANP RBM42 E4F1 PTBP1 SNRPN FOXK1 KDM1A	2.88e-04	1294	71	10	30804502
Pubmed	CHD5 is required for neurogenesis and has a dual role in facilitating gene expression and polycomb gene repression.	SOX3 CDH5	3.16e-04	13	71	2	23948251
Pubmed	Loss of the tumor suppressor BAP1 causes myeloid transformation.	PIP5K1C FOXK1	3.16e-04	13	71	2	22878500
Pubmed	Regulation of otocyst patterning by Tbx2 and Tbx3 is required for inner ear morphogenesis in the mouse.	SOX3 OTX1 HMX3	3.25e-04	65	71	3	33795231
Pubmed	Ubiquitin-assisted phase separation of dishevelled-2 promotes Wnt signalling.	NUMBL LEMD3 IRS2 FOXK1	3.38e-04	161	71	4	36398662
Pubmed	FOXO1-mediated activation of Akt plays a critical role in vascular homeostasis.	FOXO1 IRS2	3.68e-04	14	71	2	24874427
Pubmed	Inactivation of Numb and Numblike in embryonic dorsal forebrain impairs neurogenesis and disrupts cortical morphogenesis.	OTX1 NUMBL	3.68e-04	14	71	2	14687546
Pubmed	Continuing role for mouse Numb and Numbl in maintaining progenitor cells during cortical neurogenesis.	NUMBL MSI2	3.68e-04	14	71	2	15273690
Pubmed	Histone modifications defining active genes persist after transcriptional and mitotic inactivation.	KAT2B SMARCA5	3.68e-04	14	71	2	15616580
Pubmed	CHIP as a membrane-shuttling proteostasis sensor.	OTX1 DYNC2I2 MSI2	3.71e-04	68	71	3	29091030
Pubmed	Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1.	RTF1 OSBP PUF60 IDH3G PTBP1 RBM23 FOXK1	3.74e-04	653	71	7	33742100
Pubmed	SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation-Phosphorylation Cross-talk.	SLC25A22 PUF60 PUM2 PTBP1 SNRPN KDM1A MSI2	3.81e-04	655	71	7	35819319
Pubmed	FAM105A/OTULINL Is a Pseudodeubiquitinase of the OTU-Class that Localizes to the ER Membrane.	OSBP SLC12A2 CLCN7 LEMD3 CLPTM1 TMEM131	3.93e-04	468	71	6	31056421
Pubmed	A Notch-dependent transcriptional hierarchy promotes mesenchymal transdifferentiation in the cardiac cushion.	MTF1 CDH5	4.24e-04	15	71	2	24633789
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	SLC25A22 KAT2B SMARCA5 AP3S1 HMCN2 IRS2 FOXK1 KDM1A NOVA2	4.37e-04	1116	71	9	31753913
Pubmed	FCoR-Foxo1 Axis Regulates α-Cell Mass through Repression of Arx Expression.	FOXO1 ARX	4.84e-04	16	71	2	31923647
Pubmed	A hypomorphic lsd1 allele results in heart development defects in mice.	CDH5 KDM1A	4.84e-04	16	71	2	23637775
Pubmed	Identification of forkhead transcription factors in cortical and dopaminergic areas of the adult murine brain.	FOXO1 FOXK1	4.84e-04	16	71	2	16376864
Pubmed	Delayed fusion and altered gene expression contribute to semicircular canal defects in Chd7 deficient mice.	OTX1 HMX3	4.84e-04	16	71	2	22705977
Pubmed	Cell type-specific Rab32 and Rab38 cooperate with the ubiquitous lysosome biogenesis machinery to synthesize specialized lysosome-related organelles.	AP3S1 AP3S2	4.84e-04	16	71	2	23247405
Pubmed	High-throughput analysis of promoter occupancy reveals new targets for Arx, a gene mutated in mental retardation and interneuronopathies.	ARX SNRPN	5.48e-04	17	71	2	21966449
Pubmed	Six1 controls patterning of the mouse otic vesicle.	OTX1 HMX3	5.48e-04	17	71	2	14695375
Pubmed	Dlx5 and Dlx6 homeobox genes are required for specification of the mammalian vestibular apparatus.	OTX1 HMX3	5.48e-04	17	71	2	16900517
Pubmed	Elucidation of the BMI1 interactome identifies novel regulatory roles in glioblastoma.	OSBP AP3S1 IRS2 FOXK1 PARP12	5.74e-04	329	71	5	34316702
Pubmed	MTHFR and MSX1 contribute to the risk of nonsyndromic cleft lip/palate.	FOXE1 CLPTM1	6.16e-04	18	71	2	20572854
Pubmed	The schizophrenia susceptibility factor dysbindin and its associated complex sort cargoes from cell bodies to the synapse.	AP3S1 AP3S2	6.16e-04	18	71	2	21998198
Pubmed	Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15.	SMARCA5 PUF60 PUM2 PTBP1 RBM23 KDM1A MSI2	6.36e-04	714	71	7	28302793
Pubmed	PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry.	SMARCA5 PTBP1 KDM1A PARP12 MSI2	6.66e-04	340	71	5	24332808
Pubmed	Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain.	RTF1 PUM2 TMEM131	6.66e-04	83	71	3	9039502
Interaction	SATB1 interactions	FOXE1 FOXO1 KAT2B SMARCA5 FOXQ1 KDM1A	2.85e-06	116	69	6	int:SATB1
Interaction	VARS1 interactions	FOXE1 CCDC88C SMARCA5 FOXQ1 LEMD3 PRKD1 POC5 KDM1A	2.92e-06	260	69	8	int:VARS1
Interaction	LGALS9B interactions	CLCN3 SLC12A2 CLCN5 CLCN7	1.69e-05	45	69	4	int:LGALS9B
GeneFamily	Chloride voltage-gated channels	CLCN3 CLCN5 CLCN7	1.83e-06	10	46	3	302
GeneFamily	Forkhead boxes	FOXE1 FOXO1 FOXQ1 FOXK1	4.21e-06	43	46	4	508
GeneFamily	RNA binding motif containing	PUF60 RBM42 RBM24 PTBP1 RBM23 MSI2	1.58e-05	213	46	6	725
GeneFamily	BEN domain containing	NACC2 BANP	2.25e-04	9	46	2	422
GeneFamily	PHD finger proteins\|Lysine demethylases	KDM7A KDM1A	1.69e-03	24	46	2	485
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	PLEKHG4B OSBP PRKD1 IRS2	1.84e-03	206	46	4	682
Coexpression	HOUNKPE_HOUSEKEEPING_GENES	RTF1 OSBP SMARCA5 PUF60 CLPTM1 RBM42 PUM2 E4F1 PIP5K1C ZNF865 ATPAF1 KDM1A AP3S2	9.32e-06	1129	71	13	M42508
Coexpression	HOUNKPE_HOUSEKEEPING_GENES	RTF1 OSBP SMARCA5 PUF60 CLPTM1 RBM42 PUM2 E4F1 PIP5K1C ZNF865 ATPAF1 KDM1A AP3S2	1.22e-05	1158	71	13	MM1338
Coexpression	GSE9006_TYPE_1_VS_TYPE_2_DIABETES_PBMC_AT_DX_UP	SLC25A22 PUF60 CLPTM1 RBM42 E4F1 PTBP1	1.74e-05	200	71	6	M5797
Coexpression	BENPORATH_EED_TARGETS	FOXE1 SOX3 OTX1 FOXQ1 CLCN5 HMX3 ESAM YRDC CRTAC1 RBM24 GPR88 PARP12	2.52e-05	1059	71	12	M7617
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SLC12A2 ARX ELN CDH5 NOVA2	6.88e-06	166	71	5	8e5f2afbeffae5e77fcb29e8fe9f5aa49779b619
ToppCell	Endothelial-E\|World / shred on cell class and cell subclass (v4)	FOXO1 TMEM158 ESAM ELN CDH5	1.13e-05	184	71	5	b4c561924c508536fd2112e91e32176b95fdf63a
ToppCell	facs-Trachea-18m-Mesenchymal-fibroblast-fibroblast_of_trachea-\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	IQSEC3 NACC2 HMX3 ARX CRTAC1	1.19e-05	186	71	5	bdc87e4631a8ea73e262e541aa84a28f24c94b00
ToppCell	droplet-Lung-18m-Endothelial-arterial_endothelial\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TMEM158 ESAM PRKD1 ELN CDH5	1.23e-05	187	71	5	12129e02638c20d9b7c1c6e512d48bfd966e1029
ToppCell	droplet-Lung-18m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TMEM158 ESAM PRKD1 ELN CDH5	1.23e-05	187	71	5	83930ef55191eff9006113feaeabb3c2fa21fd05
ToppCell	PND03-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FOXO1 TMEM158 ESAM ELN CDH5	1.32e-05	190	71	5	d87b9e9ca863270a9c7f61674271a6440c97d1f4
ToppCell	PND07-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FOXO1 TMEM158 ESAM ELN CDH5	1.36e-05	191	71	5	3307dbccadb09c62b0e1c0235ec89bb294d748c3
ToppCell	PND07-Endothelial-Endothelial_blood-vessel-Macrovascular_EC\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FOXO1 TMEM158 ESAM ELN CDH5	1.36e-05	191	71	5	27f23c2254b610abac1a88d0fecff305addde9da
ToppCell	PND03-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FOXO1 TMEM158 ESAM ELN CDH5	1.39e-05	192	71	5	285a9d332a1e07b94f222d4b518dd56928b9e075
ToppCell	Smart-start-Cell-Wel_seq-Neoplastic-Differentiated-like-AC-like-AC-like-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CLCN3 CSPG5 IRS2 ELN MSI2	1.54e-05	196	71	5	45d1c0a962c4221c17393ee5566961d1deebf442
ToppCell	Brain_organoid-organoid_Paulsen_bioRxiv-1_mon-Proliferating-Cycling_Progenitors\|1_mon / Sample Type, Dataset, Time_group, and Cell type.	OTX1 ARX PUM2 TMEM131 IRS2	1.65e-05	199	71	5	358c4b3037f59378db8916a2fbe9ed4830cf1449
ToppCell	PBMC-Control-Hematopoietic-Platelet-Platelet-plt_5\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	IQSEC3 GPR137C DMRTA2 PRKD1	6.63e-05	136	71	4	27a41463e6f16deb5b1d4f17fefded9959038c07
ToppCell	PBMC-Control-Hematopoietic-Platelet-Platelet-plt_5\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	IQSEC3 GPR137C DMRTA2 PRKD1	6.63e-05	136	71	4	88b5c839d0446c6d6b7e81fc4d48f5e7e96eea11
ToppCell	Ciliated_cells-A-IPF_02\|World / lung cells shred on cell class, cell subclass, sample id	PLEKHG4B OTX1 HMX3 SLC25A31	9.95e-05	151	71	4	9d03ce73af15ef40c592d19b36aff46bebc14c40
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell_prolif\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	GPR137C ESAM CDH5 NOVA2	1.34e-04	163	71	4	1feb4ef7b8abcfca9a72c8d13c40548de79e7db2
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell__prolif\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	GPR137C ESAM CDH5 NOVA2	1.50e-04	168	71	4	37249f38f8f04ec5743097259de67b106ca2b02f
ToppCell	Adult-Endothelial-endothelial_cell_of_vein-D175\|Adult / Lineage, Cell type, age group and donor	ESAM CDH5 SNRPN SLC25A31	1.53e-04	169	71	4	e1f0298236e4a1c59077c14f0dd29a78fac12648
ToppCell	Control-T_cells-Tregs\|Control / group, cell type (main and fine annotations)	FOXO1 CCDC88C KAT2B MSI2	1.53e-04	169	71	4	e1e0983f31ec81b3fad5f9c6140d17f03f81a5dc
ToppCell	E15.5-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_artery\|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	FOXO1 ESAM ELN CDH5	1.68e-04	173	71	4	b0ff9808e38cb64a734ced498cd0546728746cd5
ToppCell	droplet-Mammary_Gland-nan-3m-Endothelial-nan\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ESAM PRKD1 CDH5 NOVA2	1.68e-04	173	71	4	fbc8ed566ea36c39c258dd6b3823c82f5d6eb17f
ToppCell	droplet-Marrow-nan-24m-Lymphocytic-late_pro-B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC12A2 NACC2 CSPG5 MSI2	1.72e-04	174	71	4	cdfc50e5383c8670ce5109736aff36406f46c03d
ToppCell	E18.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_mature\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FOXO1 TMEM158 ESAM CDH5	1.75e-04	175	71	4	2e54961846c65b185d9bd6e305dd81205579d890
ToppCell	E18.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FOXO1 TMEM158 ESAM CDH5	1.75e-04	175	71	4	efa6a05f7417d46141b6e635f258c126b7a03aa1
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	HMCN2 ESAM YRDC NOVA2	1.79e-04	176	71	4	64e426f5e84884ce2c29acf6f4b958962a63927f
ToppCell	droplet-Limb_Muscle-MUSCLE-30m\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCDC88C SMARCA5 ESAM CDH5	1.87e-04	178	71	4	01dafd19de04eff459253eaa9a35debf8f3deedf
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Endothelial-blood_vessel_EC-Mature_venous_EC\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CCDC88C ESAM CDH5 NOVA2	1.87e-04	178	71	4	60263c0bb9de3a57ba2ba543262a2ace0066fd85
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ESAM ELN CDH5 NOVA2	1.87e-04	178	71	4	5f779a66aa42d1d8e8af17b4a08d5dcc733efd4c
ToppCell	PCW_13-14-Endothelial-Endothelial_mature-endo_arterial_(9)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	CCDC88C ESAM CDH5 NOVA2	1.87e-04	178	71	4	c227da59dc7beb73f84405bf13356bdeb59d9338
ToppCell	droplet-Lung-LUNG-30m-Endothelial-Artery_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPR137C TMEM158 ESAM CDH5	1.91e-04	179	71	4	a09647750eba9d93c5efc1db3b555fefb5eec7b5
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-4M-Neuronal-ventral_progenitors_and_neurons_2\|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.	SMARCA5 ARX KDM7A MSI2	1.91e-04	179	71	4	d95367d689732ab2653e8d70d8d8e5eb15ae6eef
ToppCell	Endothelial\|World / shred by cell class for turbinate	ESAM CRTAC1 CDH5 NOVA2	1.91e-04	179	71	4	052b2681974be00efb8503fa4e2c85d91d5ebd06
ToppCell	COPD-Lymphoid-T_Regulatory\|World / Disease state, Lineage and Cell class	FOXO1 CCDC88C KAT2B MSI2	1.95e-04	180	71	4	51a12fbad5fa7bb12e6d616a02ff9b5141e2b063
ToppCell	3'-Broncho-tracheal-Endothelial-Blood_vessel_EC-capillary_endothelial_cell-EC_general_capillary-EC_general_capillary_L.2.0.2.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	GPR137C ESAM CDH5 NOVA2	1.95e-04	180	71	4	be9d99a2e22e63824fb2a91974379da45160ae43
ToppCell	RA-01._Fibroblast_I\|World / Chamber and Cluster_Paper	FOXO1 PRKD1 ELN MSI2	1.99e-04	181	71	4	2b6ddeb53a79a658e2ba78527ff48c155b20daa6
ToppCell	COVID-19-T_cells-Tregs\|COVID-19 / group, cell type (main and fine annotations)	FOXO1 CCDC88C KAT2B MSI2	1.99e-04	181	71	4	534659cf754326c6a73c0daa30e9d610612a0292
ToppCell	COVID-19-Endothelial_cells-Capillary_endothelial_cells\|COVID-19 / group, cell type (main and fine annotations)	SLC12A2 ESAM CDH5 NOVA2	1.99e-04	181	71	4	c5f9c92af1384d9089c65afdf41c6feb8345a3ae
ToppCell	3'-GW_trimst-2-SmallIntestine-Endothelial-blood_vessel_EC-Fetal_arterial_EC\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CCDC88C ESAM CDH5 NOVA2	2.04e-04	182	71	4	0346f81bbb1f309f3e9d063b20547d548d09472c
ToppCell	E15.5-Endothelial-large_vessel_endothelial_cell\|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	FOXO1 ESAM ELN CDH5	2.04e-04	182	71	4	345d0f9d5ee30434bc2aac17608ccdc9e61c8fa3
ToppCell	droplet-Lung-21m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TMEM158 ESAM ELN CDH5	2.04e-04	182	71	4	c7f2d24697affa530b748ab32b1d40bdc1bdc20a
ToppCell	droplet-Lung-21m-Endothelial-arterial_endothelial\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TMEM158 ESAM ELN CDH5	2.04e-04	182	71	4	d95635b74e8cd8bc00bfe40340806b59fb9bee43
ToppCell	droplet-Marrow-BM-30m-Lymphocytic-late_pro-B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC12A2 NACC2 CSPG5 MSI2	2.12e-04	184	71	4	1e54fd372c6e6a298f427b807c14cc49aaaffe80
ToppCell	(4)_Endothelial_cells-(40)_EC-arterial\|World / Cell class and subclass of bone marrow stroma cells in homeostatis	IFI27L2 ESAM ELN CDH5	2.12e-04	184	71	4	7e1a2971321ddcfa00d78d3e3ba7960e532f9392
ToppCell	PCW_10-12-Endothelial-Endothelial_mature-endo_arterial_(9)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	CCDC88C ESAM CDH5 NOVA2	2.12e-04	184	71	4	a809b0fa52df8a159f60f87eefcef61220af5e34
ToppCell	IPF-Lymphoid-T_Regulatory\|IPF / Disease state, Lineage and Cell class	FOXO1 CCDC88C KAT2B MSI2	2.17e-04	185	71	4	221cbd09d94cc0947d0e3c1aa14716d17cb2068d
ToppCell	IPF-Lymphoid-T_Regulatory\|World / Disease state, Lineage and Cell class	FOXO1 CCDC88C KAT2B MSI2	2.17e-04	185	71	4	77fbecdab10bacc005b1c7e22ca414cfecef13c1
ToppCell	COPD-Lymphoid-T_Regulatory\|COPD / Disease state, Lineage and Cell class	FOXO1 CCDC88C KAT2B MSI2	2.17e-04	185	71	4	846403edd4c8f646201d519055198fc38b7ffff9
ToppCell	wk_15-18-Endothelial-Blood_vessel_endothelial-Aerocyte\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	SLC12A2 ESAM CDH5 NOVA2	2.17e-04	185	71	4	7b3d30a54bec66ca6b0209c86448f4fff97ed75c
ToppCell	metastatic_Lymph_Node-Endothelial_cells-Tumor_ECs\|metastatic_Lymph_Node / Location, Cell class and cell subclass	ESAM ELN CDH5 NOVA2	2.26e-04	187	71	4	2713f526f86911fbbf6c7a3e69230f2e6bde31c3
ToppCell	Fetal_29-31_weeks-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	SLC12A2 ESAM CDH5 NOVA2	2.26e-04	187	71	4	97b2463fb37e7196dd2f92553acf8e7bc3ec40dd
ToppCell	Endothelial-A-Donor_03\|World / lung cells shred on cell class, cell subclass, sample id	ELN GPR88 CDH5 NOVA2	2.26e-04	187	71	4	fd93f3f4b82dae3bf4eef245bfedc2a9e3251b61
ToppCell	-Unknown-Endothelial-Myofibroblast\| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FOXO1 KDM7A ELN KDM1A	2.31e-04	188	71	4	6468fa95ad0395395301115286f2d8c0df5d3882
ToppCell	-Unknown-Endothelial\| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FOXO1 KDM7A ELN KDM1A	2.31e-04	188	71	4	7a81ac5c79c3eb26639b52d2b9fd5e7ef9798fd6
ToppCell	-Unknown\| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FOXO1 KDM7A ELN KDM1A	2.31e-04	188	71	4	9cb718bfe1358c6fd842f096e228eb0abb9aefc6
ToppCell	PCW_13-14-Endothelial-Endothelial_immature-endo_immature_arterial2_(6)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	CCDC88C ESAM CDH5 NOVA2	2.31e-04	188	71	4	b66f1f08827dd6c48583d871f9f33ea41e48bfb2
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CLCN5 PRKD1 TSC22D2 MSI2	2.31e-04	188	71	4	2ee64bc73a2251fd9f374be759b442cf4ed0d19e
ToppCell	Fetal_29-31_weeks-Mesenchymal-airway_smooth_muscle_cell-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	HMCN2 CSPG5 ELN SNRPN	2.31e-04	188	71	4	c29aaae3c5bb7cd6b9b3defd4d27afde3af19ba0
ToppCell	facs-Lung-EPCAM-18m-Epithelial-Basal\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FOXE1 OTX1 DMRTA2 TENT5B	2.35e-04	189	71	4	783c1db856f2defe6f3b8748dd0bc29a8102f6d1
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CLCN5 PRKD1 TSC22D2 MSI2	2.35e-04	189	71	4	f51cdc9a47371cab8ed9ae63a6f14da07ede446c
ToppCell	droplet-Kidney-nan-21m-Endothelial-kidney_cortex_artery_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ESAM ELN CDH5 NOVA2	2.35e-04	189	71	4	2ce330d8078833c05775c481e73770f9ee4a5c88
ToppCell	nucseq-Endothelial-Endothelial_Vascular-Endothelial_capillary-CAP2\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SLC12A2 ESAM CDH5 NOVA2	2.35e-04	189	71	4	b6b4da51bc7f2c13a2f940540fdc61027d084835
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Endothelial-blood_vessel_EC\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CCDC88C ESAM CDH5 NOVA2	2.35e-04	189	71	4	9e58411e51019ca59e78d3e737d65d2bcbbea2be
ToppCell	E18.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FOXO1 TMEM158 ESAM CDH5	2.35e-04	189	71	4	d17e8467699c7ca7694a313c26111f085df5204e
ToppCell	E16.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FOXO1 TMEM158 ESAM CDH5	2.35e-04	189	71	4	feedac2751ed770f80bc56fec31662b5b3826f58
ToppCell	PND07-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FOXO1 TMEM158 ESAM CDH5	2.35e-04	189	71	4	9da012fdfa9a8d488cab710a463a1d70e89f990c
ToppCell	IPF-Endothelial-VE_Capillary_A\|World / Disease state, Lineage and Cell class	SLC12A2 ESAM CDH5 NOVA2	2.35e-04	189	71	4	ea3aa3ef38f1d405bb527ae383cd12c551a3dd6f
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	HMCN2 ELN CDH5 NOVA2	2.35e-04	189	71	4	6463890d8dbee4bc198f91628a5f784970de786a
ToppCell	facs-Lung-EPCAM-18m-Epithelial-respiratory_basal_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FOXE1 OTX1 DMRTA2 TENT5B	2.35e-04	189	71	4	88b72fafbe58463543e0818f27f3dd9e5b4d34d2
ToppCell	droplet-Kidney-nan-21m-Endothelial-Pecam____Kidney_cortex_artery_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ESAM ELN CDH5 NOVA2	2.35e-04	189	71	4	473c87036e04a058b4a5138438b7ba7e1e766799
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Endothelial\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CCDC88C ESAM CDH5 NOVA2	2.35e-04	189	71	4	a34f008dfcee4012977bbc5b60de6f0329ca2f65
ToppCell	facs-MAT-Fat-18m-Endothelial\|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ESAM CDHR5 CDH5 NOVA2	2.40e-04	190	71	4	34e56c5e7ea6a8f227dbaefe73cbb8818d18b523
ToppCell	droplet-Kidney-KIDNEY-30m-Endothelial-Pecam____Kidney_cortex_artery_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ESAM ELN CDH5 NOVA2	2.40e-04	190	71	4	cb8798839c27f307955fcc94a1ee40bca95b8e99
ToppCell	facs-MAT-Fat-18m-Endothelial-nan\|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ESAM CDHR5 CDH5 NOVA2	2.40e-04	190	71	4	14cdb660ad3aabcf49572173e7628d8b99dcbe6f
ToppCell	COVID-19-kidney-AQP1+SLC14A1+EC\|kidney / Disease (COVID-19 only), tissue and cell type	ESAM ELN CDH5 NOVA2	2.40e-04	190	71	4	1519f34d31fe0817184c5865a0bc9f0cb479b1a4
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CLCN5 PRKD1 TSC22D2 MSI2	2.40e-04	190	71	4	b94df372bc08de11585b2467dba8c8fffff5cd92
ToppCell	IPF-Endothelial-VE_Capillary_A\|IPF / Disease state, Lineage and Cell class	SLC12A2 ESAM CDH5 NOVA2	2.40e-04	190	71	4	b4e35cbfe4d43d2cd51f29c3085e4d9b1012e6f0
ToppCell	Children_(3_yrs)-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	SLC12A2 ESAM CDH5 NOVA2	2.40e-04	190	71	4	0e9847d7f49b2236b8a191e1a7df37556351ba9e
ToppCell	Children_(3_yrs)-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	SLC12A2 ESAM CDH5 NOVA2	2.40e-04	190	71	4	0a351609a72fd638c84b2435782e312ee6a33aac
ToppCell	droplet-Kidney-KIDNEY-30m-Endothelial-kidney_cortex_artery_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ESAM ELN CDH5 NOVA2	2.40e-04	190	71	4	5bf3d0beee69879c95265d07fba023626a7cc808
ToppCell	wk_08-11-Epithelial-Airway_epithelial_progenitor-epi-stalk_early\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	PLEKHG4B SMARCA5 SLC12A2 TENT5B	2.40e-04	190	71	4	9f5f65869dad9a43ac94f81f9a19c72ffe5adc3c
ToppCell	facs-MAT-Fat-18m-Endothelial-endothelial_cell\|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ESAM CDHR5 CDH5 NOVA2	2.40e-04	190	71	4	9aaa48f3aad813c87a45efdbb67d255c94f6e6a4
ToppCell	PND10-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FOXO1 ESAM ELN CDH5	2.40e-04	190	71	4	9b0ad888eb20acc011904d8593bc32bdef18d050
ToppCell	PCW_10-12-Endothelial-Endothelial_immature-endo_immature_arterial2_(6)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	CCDC88C ESAM CDH5 NOVA2	2.40e-04	190	71	4	7ba2be2630183df86de21689289a8620a4cd507e
ToppCell	PND07-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FOXO1 ESAM ELN CDH5	2.45e-04	191	71	4	0e8a73f01e3ec95d242c09231bcf3790324d0a67
ToppCell	COPD-Lymphoid-T_Regulatory\|Lymphoid / Disease state, Lineage and Cell class	FOXO1 KAT2B BANP MSI2	2.45e-04	191	71	4	3ae18bc4e3dff49b5d5958da8ebc3f747274b69c
ToppCell	Fetal_29-31_weeks-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	SLC12A2 ESAM CDH5 NOVA2	2.45e-04	191	71	4	1de0bdfd13bd930691564c2673f2e66393bc0255
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CLCN5 PRKD1 TSC22D2 MSI2	2.45e-04	191	71	4	963f4f2e852bbb4faf070aafb0d368297abacd3b
ToppCell	PND07-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_mature\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FOXO1 ESAM ELN CDH5	2.45e-04	191	71	4	54bbccc554f43ba2ebdf9ea191b94c8f16081b53
ToppCell	droplet-Lung-LUNG-1m-Endothelial-Vein_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FOXO1 ESAM ELN CDH5	2.45e-04	191	71	4	9fc674a58f20b47255e4457d5195c8cff17b0414
ToppCell	LPS_only-Endothelial-Endothelial-Activated_Alv_Cap\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SLC12A2 ESAM RELL1 CDH5	2.45e-04	191	71	4	a7b18bcf27c38ad2353c239ecb309c80f3ef3359
ToppCell	Children_(3_yrs)-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)\|Children_(3_yrs) / Lineage, Cell type, age group and donor	SLC12A2 ESAM CDH5 NOVA2	2.45e-04	191	71	4	f229abf69a1217194f74b0502486907e07dba989
ToppCell	wk_20-22-Endothelial-Blood_vessel_endothelial-arterial_endo\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	SLC12A2 ESAM ELN CDH5	2.45e-04	191	71	4	0b022d8b39eac36115b269aac11a5eaa492754cc
ToppCell	P07-Endothelial-large_vessel_endothelial_cell\|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	FOXO1 TMEM158 ELN CDH5	2.45e-04	191	71	4	d162917816dd2e4767c97447c1cddae9397713ab
ToppCell	droplet-Lung-LUNG-1m-Endothelial-vein_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FOXO1 ESAM ELN CDH5	2.45e-04	191	71	4	c379a499dabf3c9ed80f47adbb2d949821c5b053
ToppCell	droplet-Kidney-KIDNEY-1m-Endothelial-kidney_cortex_artery_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ESAM ELN CDH5 NOVA2	2.50e-04	192	71	4	c0498baa2556e1597c00df2e75efadeb14bd34ef
ToppCell	droplet-Lung-1m-Endothelial-venous_endothelial\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FOXO1 ESAM ELN CDH5	2.50e-04	192	71	4	1990dc8a81594018a5bf596be99d0b5f0af0f58f
ToppCell	Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)\|World / Lineage, Cell type, age group and donor	SLC12A2 ESAM CDH5 NOVA2	2.50e-04	192	71	4	1e156bab5ecf64627890d2de9b27603d9a01f28d
ToppCell	droplet-Kidney-KIDNEY-1m-Endothelial-Pecam____Kidney_cortex_artery_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ESAM ELN CDH5 NOVA2	2.50e-04	192	71	4	cb906b10cad76e978c5c0b966215368ebef30e51
ToppCell	Fetal_29-31_weeks-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	SLC12A2 ESAM CDH5 NOVA2	2.50e-04	192	71	4	7197e401e563441ab94815f7619e032ebef9e586
ToppCell	droplet-Kidney-nan-18m-Endothelial-kidney_cortex_artery_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ESAM ELN CDH5 NOVA2	2.50e-04	192	71	4	144503af50274eaed5cf6effa892c640eab28663
ToppCell	droplet-Lung-1m-Endothelial-venous_endothelial-vein_endothelial_cell-vein_endothelial_cell\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FOXO1 ESAM ELN CDH5	2.50e-04	192	71	4	845cc9c18b4436b07dd3ce7980052683937546d2
Disease	osteopetrosis (implicated_via_orthology)	CLCN3 CLCN5 CLCN7	4.44e-07	7	70	3	DOID:13533 (implicated_via_orthology)
Disease	Dent disease (implicated_via_orthology)	CLCN3 CLCN5	1.66e-05	3	70	2	DOID:0050699 (implicated_via_orthology)
Disease	syndromic X-linked intellectual disability (implicated_via_orthology)	ARX KDM7A	1.54e-04	8	70	2	DOID:0060309 (implicated_via_orthology)
Disease	early infantile epileptic encephalopathy (implicated_via_orthology)	ARX IDH3G	3.01e-04	11	70	2	DOID:0050709 (implicated_via_orthology)
Disease	Early infantile epileptic encephalopathy with suppression bursts	SLC25A22 ARX	6.52e-04	16	70	2	C0393706
Disease	low density lipoprotein cholesterol measurement, free cholesterol:total lipids ratio	DMRTA2 CRTAC1 POC5 TSC22D2	1.32e-03	200	70	4	EFO_0004611, EFO_0020945

Protein segments in the cluster

Peptide	Gene	Start	Entry
LAPASEIAGAGAASV	PLAAT2	36	Q9NWW9
IAVASSDPAAAGVDG	BANP	456	Q8N9N5
LASGAVPAREAGSAV	CSPG5	26	O95196
EGGLSAAPARAVSAV	AP3S2	151	P59780
EAGLAGAPARAVSAV	AP3S1	151	Q92572
GAGAGVVVKDAAAPS	CDHR5	366	Q9HBB8
GLLAVAAVAAAGANP	CDH5	16	P33151
AAAAASLPVSVAGGL	DMRTA2	36	Q96SC8
RVDAAAAAAAAAGGP	DMRTA2	386	Q96SC8
EAGTPVAAGTTAAAI	NUMBL	276	Q9Y6R0
GAGIQLPSTAAAAAA	RBM23	376	Q86U06
ITAAAPGTAAAAAAA	RBM24	201	Q9BX46
EASAAVAVGAGGAPA	RBM42	261	Q9BTD8
AAAYGPVAAAAVAAA	MSI2	246	Q96DH6
PVAAAAVAAARGSGS	MSI2	251	Q96DH6
AAGLAAAATLAGPAV	PUM2	326	Q8TB72
TAAATVAAAGPAAAA	LEMD3	71	Q9Y2U8
VPVSALGAGSAATAA	POC5	451	Q8NA72
AAAAAVSVAAPGRAS	KDM7A	16	Q6ZMT4
VAAAAAAAAAALVPG	PRKD1	16	Q15139
LPGVGDAAAAAVAAT	GPR88	351	Q9GZN0
AAAAVGGALAVGAVP	IFI27L2	6	Q9H2X8
ACGPATAVAAAGTAE	KAT2B	51	Q92831
AAPGAAGASVGAAAA	HMX3	191	A6NHT5
TAVSAAVAVAVAGAP	HMCN2	11	Q8NDA2
GAVAAASGAAVPGSV	GPR137C	31	Q8N3F9
AGVAALATVGVASGP	DYNC2I2	16	Q96EX3
QSATAPAIATAGAGA	CCDC88C	1901	Q9P219
AGAAAGVSAAFGAPV	CLCN7	291	P51798
AGCVAGSAAAVAVNP	SLC25A22	231	Q9H936
AAAVAAVAAGRSPEG	KCNS1	251	Q96KK3
SGVLAAVAAGANPAA	NOVA2	306	Q9UNW9
DSVVAAAAVAAGRPS	IQSEC3	221	Q9UPP2
PGSGAASGTVVAAAA	OSBP	41	P22059
AAAAAGLGGNPVAAA	OTX1	151	P32242
GGAAAAPERVVLAAS	PARP12	56	Q9H0J9
AAAGAAAAGARPVSV	IRS2	371	Q9Y4H2
AGGVAAAVSKTAVAP	SLC25A31	26	Q9H0C2
GSAALAAGARAVPAA	ATMIN	11	O43313
AAGARAVPAATTGAA	ATMIN	16	O43313
AVPAATTGAAAAASG	ATMIN	21	O43313
APGSVAAAVAAAAAA	FOXO1	86	Q12778
ATVAGSAAKAVLGPA	IDH3G	6	P51553
AAAAAAAATGTEAGP	KDM1A	11	O60341
VAAAGGAGPAVLQVA	ATPAF1	6	Q5TC12
AAAAGVSVAFGAPIG	CLCN5	316	P51795
SAVAGAAPALVAAAA	FOXK1	81	P85037
VSTGPGAAVVAGAVV	ESAM	241	Q96AP7
AAAAATATAGPRGEA	ARX	111	Q96QS3
CPVAATGAVAAAAAA	ARX	266	Q96QS3
AAAGAATAAPVLVDG	CRTAC1	631	Q9NQ79
GEGAVAAVAAALAPS	E4F1	26	Q66K89
TGTGVGPQAAAAAAA	ELN	246	P15502
AGVGTPAAAAAAAAA	ELN	296	P15502
VGAGPAAAAAAAKAA	ELN	681	P15502
EAIPAAAAAAVVAEG	FOXQ1	76	Q9C009
CVGRAAAAAAAVAVP	RTF1	6	Q92541
AAAAAAVAVPLAGGQ	RTF1	11	Q92541
AAAAAAAASSPVGVG	SOX3	241	P41225
GGSEPAAAAAVVAAG	PUF60	16	Q9UHX1
AAAAVAATASIAGAP	SNRPN	151	P63162
VTGGLAAPLVAAGAA	TMCO4	206	Q5TGY1
AAPLVAAGAATIIGS	TMCO4	211	Q5TGY1
AAAAAPANGGGVVSA	TSC22D2	96	O75157
AAAAAAAAAIFPGAV	FOXE1	171	O00358
VPGLSVVAGASASAA	MTF1	496	Q14872
GVEASPAGASAAVEV	PIP5K1C	596	O60331
AAATAVATAAPAGGG	TENT5B	21	Q96A09
TAAAPVAEVPTAAGA	CLPTM1	606	O96005
AASAAGVSVAFGAPI	CLCN3	316	P51790
AAAAAAAVVYGAVPV	ZNF865	506	P0CJ78
AAVPAGTTAAAAAAA	TMEM158	271	Q8WZ71
ATSVAAEAFPGAGVA	PLEKHG4B	556	Q96PX9
VLAAAVFVGGAVSSP	RELL1	11	Q8IUW5
AGVGETPSAAALAAA	SLC12A2	16	P55011
AVSTSAGAGLEPAAA	TMEM131	16	Q92545
GPEGVAAQAVASAAS	SMARCA5	36	O60264
AAAAAAAAGRIAIPG	PTBP1	316	P26599
RAAVAASVGLSEGPA	YRDC	11	Q86U90
GPRDGVAVAAGAAVA	NACC2	196	Q96BF6
VAVAAGAAVAAGTAP	NACC2	201	Q96BF6