Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	N-acetylglucosamine-6-sulfatase activity	SULF2 SULF1	1.49e-05	3	45	2	GO:0008449
GeneOntologyMolecularFunction	arylsulfatase activity	SULF2 SULF1	4.44e-04	14	45	2	GO:0004065
GeneOntologyMolecularFunction	sulfuric ester hydrolase activity	SULF2 SULF1	6.61e-04	17	45	2	GO:0008484
GeneOntologyBiologicalProcess	esophagus smooth muscle contraction	SULF2 SULF1	4.65e-06	2	45	2	GO:0014846
GeneOntologyCellularComponent	presynaptic active zone	DGKI GRIN2B SHANK2 PCLO	2.38e-04	141	45	4	GO:0048786
GeneOntologyCellularComponent	post-mRNA release spliceosomal complex	CRNKL1 XAB2	2.95e-04	12	45	2	GO:0071014
GeneOntologyCellularComponent	Prp19 complex	CRNKL1 XAB2	5.33e-04	16	45	2	GO:0000974
Domain	Extracellular_sulfatase	SULF2 SULF1	5.93e-06	2	46	2	IPR014615
Domain	Extracellular_sulfatase_C	SULF2 SULF1	5.93e-06	2	46	2	IPR024609
Domain	DUF3740	SULF2 SULF1	5.93e-06	2	46	2	PF12548
Domain	SAA	SAA1 SAA2	3.55e-05	4	46	2	PF00277
Domain	SAA	SAA1 SAA2	3.55e-05	4	46	2	SM00197
Domain	SAA	SAA1 SAA2	3.55e-05	4	46	2	PS00992
Domain	Serum_amyloid_A	SAA1 SAA2	5.91e-05	5	46	2	IPR000096
Domain	HAT	CRNKL1 XAB2	2.64e-04	10	46	2	IPR003107
Domain	HAT	CRNKL1 XAB2	2.64e-04	10	46	2	SM00386
Domain	FKBP_C	FKBP10 AIP	6.97e-04	16	46	2	PF00254
Domain	Sulfatase_CS	SULF2 SULF1	6.97e-04	16	46	2	IPR024607
Domain	FKBP_PPIASE	FKBP10 AIP	6.97e-04	16	46	2	PS50059
Domain	SULFATASE_1	SULF2 SULF1	7.88e-04	17	46	2	PS00523
Domain	SULFATASE_2	SULF2 SULF1	7.88e-04	17	46	2	PS00149
Domain	Sulfatase	SULF2 SULF1	8.85e-04	18	46	2	PF00884
Domain	Sulfatase_N	SULF2 SULF1	8.85e-04	18	46	2	IPR000917
Domain	PPIase_FKBP_dom	FKBP10 AIP	1.10e-03	20	46	2	IPR001179
Domain	zf-C2H2	MECOM ZNF112 ZNF473 ZNF658 ZNF268 CASZ1 ZNF829	1.43e-03	693	46	7	PF00096
Domain	KRAB	ZNF112 ZNF473 ZNF658 ZNF268 ZNF829	1.81e-03	358	46	5	PS50805
Domain	KRAB	ZNF112 ZNF473 ZNF658 ZNF268 ZNF829	1.81e-03	358	46	5	PF01352
Domain	KRAB	ZNF112 ZNF473 ZNF658 ZNF268 ZNF829	2.07e-03	369	46	5	SM00349
Domain	KRAB	ZNF112 ZNF473 ZNF658 ZNF268 ZNF829	2.09e-03	370	46	5	IPR001909
Domain	Alkaline_phosphatase_core	SULF2 SULF1	2.64e-03	31	46	2	IPR017850
Domain	Alkaline_Pase-like_a/b/a	SULF2 SULF1	2.64e-03	31	46	2	IPR017849
Domain	-	SULF2 SULF1	2.64e-03	31	46	2	3.40.720.10
Domain	ZINC_FINGER_C2H2_2	MECOM ZNF112 ZNF473 ZNF658 ZNF268 CASZ1 ZNF829	2.69e-03	775	46	7	PS50157
Domain	ZINC_FINGER_C2H2_1	MECOM ZNF112 ZNF473 ZNF658 ZNF268 CASZ1 ZNF829	2.73e-03	777	46	7	PS00028
Domain	Znf_C2H2-like	MECOM ZNF112 ZNF473 ZNF658 ZNF268 CASZ1 ZNF829	3.12e-03	796	46	7	IPR015880
Domain	Znf_C2H2	MECOM ZNF112 ZNF473 ZNF658 ZNF268 CASZ1 ZNF829	3.32e-03	805	46	7	IPR007087
Domain	ZnF_C2H2	MECOM ZNF112 ZNF473 ZNF658 ZNF268 CASZ1 ZNF829	3.39e-03	808	46	7	SM00355
Domain	ER_TARGET	FKBP10 UGGT2	5.98e-03	47	46	2	PS00014
Domain	TPR-contain_dom	CRNKL1 AIP XAB2	5.99e-03	150	46	3	IPR013026
Domain	-	MECOM ZNF112 ZNF473 ZNF658 ZNF268 ZNF829	6.13e-03	679	46	6	3.30.160.60
Domain	TPR_2	AIP XAB2	6.74e-03	50	46	2	PF07719
Domain	TPR_2	AIP XAB2	6.74e-03	50	46	2	IPR013105
Domain	Znf_C2H2/integrase_DNA-bd	MECOM ZNF112 ZNF473 ZNF658 ZNF268 ZNF829	6.81e-03	694	46	6	IPR013087
Domain	EF_Hand_1_Ca_BS	FLG FKBP10 DNAH7	9.14e-03	175	46	3	IPR018247
Pubmed	Polymorphisms in the SAA1/2 gene are associated with carotid intima media thickness in healthy Han Chinese subjects: the Cardiovascular Risk Survey.	SAA1 SAA2	1.71e-06	2	46	2	21103356
Pubmed	The rate and significance of type 1/type 2 serum amyloid A protein gene polymorphisms in patients with ankylosing spondylitis and amyloidosis.	SAA1 SAA2	1.71e-06	2	46	2	26300108
Pubmed	DNA sequence evidence for polymorphic forms of human serum amyloid A (SAA).	SAA1 SAA2	1.71e-06	2	46	2	3800865
Pubmed	Cloning and characterization of two extracellular heparin-degrading endosulfatases in mice and humans.	SULF2 SULF1	1.71e-06	2	46	2	12368295
Pubmed	Heparan sulfate 6-O-endosulfatases: discrete in vivo activities and functional co-operativity.	SULF2 SULF1	1.71e-06	2	46	2	16901266
Pubmed	Short SULF1/SULF2 splice variants predominate in mammary tumours with a potential to facilitate receptor tyrosine kinase-mediated cell signalling.	SULF2 SULF1	1.71e-06	2	46	2	27294358
Pubmed	Serum Amyloid A Promotes Inflammation-Associated Damage and Tumorigenesis in a Mouse Model of Colitis-Associated Cancer.	SAA1 SAA2	1.71e-06	2	46	2	34217896
Pubmed	Serum amyloid A, an acute phase protein, inhibits platelet activation.	SAA1 SAA2	1.71e-06	2	46	2	1697614
Pubmed	Heparan Sulfate-Editing Extracellular Sulfatases Enhance VEGF Bioavailability for Ischemic Heart Repair.	SULF2 SULF1	1.71e-06	2	46	2	31434553
Pubmed	Overexpression of Sulf2 in idiopathic pulmonary fibrosis.	SULF2 SULF1	1.71e-06	2	46	2	23418199
Pubmed	Impact of serum amyloid A on high density lipoprotein composition and levels.	SAA1 SAA2	1.71e-06	2	46	2	20667817
Pubmed	Serum Amyloid A Induces Inflammation, Proliferation and Cell Death in Activated Hepatic Stellate Cells.	SAA1 SAA2	1.71e-06	2	46	2	26937641
Pubmed	Extracellular sulfatases support cartilage homeostasis by regulating BMP and FGF signaling pathways.	SULF2 SULF1	1.71e-06	2	46	2	20479257
Pubmed	Serum amyloid A facilitates the binding of high-density lipoprotein from mice injected with lipopolysaccharide to vascular proteoglycans.	SAA1 SAA2	1.71e-06	2	46	2	21474830
Pubmed	Multi-tasking Sulf1/Sulf2 enzymes do not only facilitate extracellular cell signalling but also participate in cell cycle related nuclear events.	SULF2 SULF1	1.71e-06	2	46	2	29360432
Pubmed	Regulation of fractone heparan sulfate composition in young and aged subventricular zone neurogenic niches.	SULF2 SULF1	1.71e-06	2	46	2	34324645
Pubmed	Serum amyloid A protein induces production of matrix metalloproteinases by human synovial fibroblasts.	SAA1 SAA2	1.71e-06	2	46	2	9605178
Pubmed	Sulf loss influences N-, 2-O-, and 6-O-sulfation of multiple heparan sulfate proteoglycans and modulates fibroblast growth factor signaling.	SULF2 SULF1	1.71e-06	2	46	2	18687675
Pubmed	Loss of endothelial sulfatase-1 after experimental sepsis attenuates subsequent pulmonary inflammatory responses.	SULF2 SULF1	1.71e-06	2	46	2	31461325
Pubmed	Pathogenic serum amyloid A 1.1 shows a long oligomer-rich fibrillation lag phase contrary to the highly amyloidogenic non-pathogenic SAA2.2.	SAA1 SAA2	1.71e-06	2	46	2	23223242
Pubmed	HSulf-1 and HSulf-2 are potent inhibitors of myeloma tumor growth in vivo.	SULF2 SULF1	1.71e-06	2	46	2	16192265
Pubmed	Functional consequences of the subdomain organization of the sulfs.	SULF2 SULF1	1.71e-06	2	46	2	19520866
Pubmed	Epithelial Deletion of Sulf2 Exacerbates Bleomycin-Induced Lung Injury, Inflammation, and Mortality.	SULF2 SULF1	1.71e-06	2	46	2	28657777
Pubmed	Structure of a human serum amyloid A gene and modulation of its expression in transfected L cells.	SAA1 SAA2	1.71e-06	2	46	2	2890635
Pubmed	Intestinal epithelial serum amyloid A modulates bacterial growth in vitro and pro-inflammatory responses in mouse experimental colitis.	SAA1 SAA2	1.71e-06	2	46	2	21067563
Pubmed	The human acute-phase serum amyloid A gene family: structure, evolution and expression in hepatoma cells.	SAA1 SAA2	1.71e-06	2	46	2	1656519
Pubmed	The SULFs, extracellular sulfatases for heparan sulfate, promote the migration of corneal epithelial cells during wound repair.	SULF2 SULF1	1.71e-06	2	46	2	23950901
Pubmed	Influence of Serum Amyloid A (SAA1) and SAA2 gene polymorphisms on renal amyloidosis, and on SAA/C-reactive protein values in patients with familial mediterranean fever in the Turkish population.	SAA1 SAA2	1.71e-06	2	46	2	15170927
Pubmed	Sulf1 and Sulf2 Differentially Modulate Heparan Sulfate Proteoglycan Sulfation during Postnatal Cerebellum Development: Evidence for Neuroprotective and Neurite Outgrowth Promoting Functions.	SULF2 SULF1	1.71e-06	2	46	2	26448642
Pubmed	Acute-phase, but not constitutive serum amyloid A (SAA) is chemotactic for cultured human aortic smooth muscle cells.	SAA1 SAA2	1.71e-06	2	46	2	12557751
Pubmed	Serum amyloid alpha 1-2 are not required for liver inflammation in the 4T1 murine breast cancer model.	SAA1 SAA2	1.71e-06	2	46	2	36817472
Pubmed	Enhanced tumorigenic potential of colorectal cancer cells by extracellular sulfatases.	SULF2 SULF1	1.71e-06	2	46	2	25477293
Pubmed	Association of genetic variation in serum amyloid-A with cardiovascular disease and interactions with IL6, IL1RN, IL1beta and TNF genes in the Cardiovascular Health Study.	SAA1 SAA2	1.71e-06	2	46	2	19729864
Pubmed	Serum amyloid A is a soluble pattern recognition receptor that drives type 2 immunity.	SAA1 SAA2	1.71e-06	2	46	2	32572240
Pubmed	Acute-phase serum amyloid A: an inflammatory adipokine and potential link between obesity and its metabolic complications.	SAA1 SAA2	1.71e-06	2	46	2	16737350
Pubmed	Diffusion magnetic resonance tractography-based evaluation of commissural fiber abnormalities in a heparan sulfate endosulfatase-deficient mouse brain.	SULF2 SULF1	1.71e-06	2	46	2	35131262
Pubmed	Murine apolipoprotein serum amyloid A in solution forms a hexamer containing a central channel.	SAA1 SAA2	1.71e-06	2	46	2	12456883
Pubmed	The Impairment of Macrophage-to-Feces Reverse Cholesterol Transport during Inflammation Does Not Depend on Serum Amyloid A.	SAA1 SAA2	1.71e-06	2	46	2	23431457
Pubmed	SULF1/SULF2 splice variants differentially regulate pancreatic tumour growth progression.	SULF2 SULF1	1.71e-06	2	46	2	24726914
Pubmed	Effect of serum amyloid A on selected in vitro functions of isolated human neutrophils.	SAA1 SAA2	1.71e-06	2	46	2	9823935
Pubmed	Organ-specific sulfation patterns of heparan sulfate generated by extracellular sulfatases Sulf1 and Sulf2 in mice.	SULF2 SULF1	1.71e-06	2	46	2	22298771
Pubmed	AA amyloidosis-resistant CE/J mice have Saa1 and Saa2 genes that encode an identical SAA isoform.	SAA1 SAA2	1.71e-06	2	46	2	24228751
Pubmed	The frequencies of the serum amyloid A2 alleles in healthy (Turkish, Azerbaijan and Kazakh) populations.	SAA1 SAA2	1.71e-06	2	46	2	16152805
Pubmed	Large-scale isotype-specific quantification of Serum amyloid A 1/2 by multiple reaction monitoring in crude sera.	SAA1 SAA2	1.71e-06	2	46	2	22300576
Pubmed	Extracellular matrix-anchored serum amyloid A preferentially induces mast cell adhesion.	SAA1 SAA2	1.71e-06	2	46	2	9252455
Pubmed	No evidence for a role of adipose tissue-derived serum amyloid a in the development of insulin resistance or obesity-related inflammation in hSAA1(+/-) transgenic mice.	SAA1 SAA2	1.71e-06	2	46	2	23967285
Pubmed	Differential glucocorticoid enhancement of the cytokine-driven transcriptional activation of the human acute phase serum amyloid A genes, SAA1 and SAA2.	SAA1 SAA2	1.71e-06	2	46	2	12077270
Pubmed	A novel biologic function of serum amyloid A. Induction of T lymphocyte migration and adhesion.	SAA1 SAA2	1.71e-06	2	46	2	7636186
Pubmed	Inflammatory remodeling of the HDL proteome impairs cholesterol efflux capacity.	SAA1 SAA2	1.71e-06	2	46	2	25995210
Pubmed	Diversity and complexity of the mouse Saa1 and Saa2 genes.	SAA1 SAA2	1.71e-06	2	46	2	24521869
Pubmed	Regulation of the human acute phase serum amyloid A genes by tumour necrosis factor-alpha, interleukin-6 and glucocorticoids in hepatic and epithelial cell lines.	SAA1 SAA2	1.71e-06	2	46	2	14871291
Pubmed	Endosulfatases SULF1 and SULF2 limit Chlamydia muridarum infection.	SULF2 SULF1	1.71e-06	2	46	2	23480519
Pubmed	Defining lipid-binding regions of human serum amyloid A using its fragment peptides.	SAA1 SAA2	1.71e-06	2	46	2	19665458
Pubmed	Abnormal Pyramidal Decussation and Bilateral Projection of the Corticospinal Tract Axons in Mice Lacking the Heparan Sulfate Endosulfatases, Sulf1 and Sulf2.	SULF2 SULF1	1.71e-06	2	46	2	32038163
Pubmed	Linkage of protection against amyloid fibril formation in the mouse to a single, autosomal dominant gene.	SAA1 SAA2	1.71e-06	2	46	2	7760010
Pubmed	Serum amyloid A exhibits pH dependent antibacterial action and contributes to host defense against Staphylococcus aureus cutaneous infection.	SAA1 SAA2	1.71e-06	2	46	2	31819008
Pubmed	SAA does not induce cytokine production in physiological conditions.	SAA1 SAA2	1.71e-06	2	46	2	23165195
Pubmed	Isolation and purification of two major serum amyloid A isotypes SAA1 and SAA2 from the acute phase plasma of mice.	SAA1 SAA2	1.71e-06	2	46	2	9518179
Pubmed	Expression of novel extracellular sulfatases Sulf-1 and Sulf-2 in normal and osteoarthritic articular cartilage.	SULF2 SULF1	1.71e-06	2	46	2	18507859
Pubmed	Heterogeneity of human serum amyloid A protein. Five different variants from one individual demonstrated by cDNA sequence analysis.	SAA1 SAA2	1.71e-06	2	46	2	1971508
Pubmed	Serum amyloid A induces calcium mobilization and chemotaxis of human monocytes by activating a pertussis toxin-sensitive signaling pathway.	SAA1 SAA2	1.71e-06	2	46	2	7561109
Pubmed	Differential involvement of the extracellular 6-O-endosulfatases Sulf1 and Sulf2 in brain development and neuronal and behavioural plasticity.	SULF2 SULF1	1.71e-06	2	46	2	20394677
Pubmed	Heparan sulfate 6-O-endosulfatases, Sulf1 and Sulf2, regulate glomerular integrity by modulating growth factor signaling.	SULF2 SULF1	1.71e-06	2	46	2	26764203
Pubmed	Expression of Heparan Sulfate Endosulfatases in the Adult Mouse Brain: Co-expression of Sulf1 and Dopamine D1/D2 Receptors.	SULF2 SULF1	1.71e-06	2	46	2	34489650
Pubmed	Human serum amyloid A. Three hepatic mRNAs and the corresponding proteins in one person.	SAA1 SAA2	1.71e-06	2	46	2	3183061
Pubmed	Serum amyloid A is a chemoattractant: induction of migration, adhesion, and tissue infiltration of monocytes and polymorphonuclear leukocytes.	SAA1 SAA2	1.71e-06	2	46	2	7516407
Pubmed	SULFs in human neoplasia: implication as progression and prognosis factors.	SULF2 SULF1	1.71e-06	2	46	2	21599997
Pubmed	Complete primary structures of two major murine serum amyloid A proteins deduced from cDNA sequences.	SAA1 SAA2	1.71e-06	2	46	2	3857624
Pubmed	Structural prerequisites for serum amyloid A fibril formation.	SAA1 SAA2	1.71e-06	2	46	2	8376413
Pubmed	Sulfs are regulators of growth factor signaling for satellite cell differentiation and muscle regeneration.	SULF2 SULF1	1.71e-06	2	46	2	17920055
Pubmed	SULF1/SULF2 reactivation during liver damage and tumour growth.	SULF2 SULF1	1.71e-06	2	46	2	27013228
Pubmed	A seven-transmembrane, G protein-coupled receptor, FPRL1, mediates the chemotactic activity of serum amyloid A for human phagocytic cells.	SAA1 SAA2	1.71e-06	2	46	2	9892621
Pubmed	The human serum amyloid A protein (SAA) superfamily gene cluster: mapping to chromosome 11p15.1 by physical and genetic linkage analysis.	SAA1 SAA2	5.13e-06	3	46	2	8188252
Pubmed	Serum amyloid A regulates monopoiesis in hyperlipidemic Ldlr(-/-) mice.	SAA1 SAA2	5.13e-06	3	46	2	27339627
Pubmed	SAA1 is transcriptionally activated by STAT3 and accelerates renal interstitial fibrosis by inducing endoplasmic reticulum stress.	SAA1 SAA2	5.13e-06	3	46	2	34597680
Pubmed	Expression of the heparan sulfate 6-O-endosulfatases, Sulf1 and Sulf2, in the avian and mammalian inner ear suggests a role for sulfation during inner ear development.	SULF2 SULF1	5.13e-06	3	46	2	25370455
Pubmed	Serum amyloid A3 is a high density lipoprotein-associated acute-phase protein.	SAA1 SAA2	5.13e-06	3	46	2	29247043
Pubmed	Diverse gene expression for isotypes of murine serum amyloid A protein during acute phase reaction.	SAA1 SAA2	5.13e-06	3	46	2	3456645
Pubmed	Structure of the murine serum amyloid A gene family. Gene conversion.	SAA1 SAA2	5.13e-06	3	46	2	3013853
Pubmed	High-density lipoprotein inhibits serum amyloid A-mediated reactive oxygen species generation and NLRP3 inflammasome activation.	SAA1 SAA2	5.13e-06	3	46	2	29976759
Pubmed	Serum Amyloid A Is an Exchangeable Apolipoprotein.	SAA1 SAA2	5.13e-06	3	46	2	29976766
Pubmed	Serum amyloid A stimulates lipoprotein-associated phospholipase A2 expression in vitro and in vivo.	SAA1 SAA2	5.13e-06	3	46	2	23623642
Pubmed	WT1-dependent sulfatase expression maintains the normal glomerular filtration barrier.	SULF2 SULF1	5.13e-06	3	46	2	21719793
Pubmed	Impact of individual acute phase serum amyloid A isoforms on HDL metabolism in mice.	SAA1 SAA2	5.13e-06	3	46	2	27018443
Pubmed	Comparison of C-reactive protein and serum amyloid a protein in septic shock patients.	SAA1 SAA2	5.13e-06	3	46	2	18385816
Pubmed	Widespread expression of serum amyloid A in histologically normal human tissues. Predominant localization to the epithelium.	SAA1 SAA2	5.13e-06	3	46	2	9815279
Pubmed	Serum amyloid A promotes cholesterol efflux mediated by scavenger receptor B-I.	SAA1 SAA2	5.13e-06	3	46	2	16120612
Pubmed	Serum amyloid A is a retinol binding protein that transports retinol during bacterial infection.	SAA1 SAA2	5.13e-06	3	46	2	25073702
Pubmed	mRNA expression and release of interleukin-8 induced by serum amyloid A in neutrophils and monocytes.	SAA1 SAA2	5.13e-06	3	46	2	12857601
Pubmed	Characterization of human serum amyloid A protein isoforms separated by two-dimensional electrophoresis by liquid chromatography/electrospray ionization tandem mass spectrometry.	SAA1 SAA2	5.13e-06	3	46	2	8783012
Pubmed	Heparan sulfate 6-O-endosulfatases (Sulfs) coordinate the Wnt signaling pathways to regulate myoblast fusion during skeletal muscle regeneration.	SULF2 SULF1	5.13e-06	3	46	2	22865881
Pubmed	Structural diversity of murine serum amyloid A genes. Evolutionary implications.	SAA1 SAA2	5.13e-06	3	46	2	3624868
Pubmed	Desulfation of Heparan Sulfate by Sulf1 and Sulf2 Is Required for Corticospinal Tract Formation.	SULF2 SULF1	5.13e-06	3	46	2	29062064
Pubmed	Expression of SAA1, SAA2 and SAA4 genes in human primary monocytes and monocyte-derived macrophages.	SAA1 SAA2	5.13e-06	3	46	2	31100086
Pubmed	The differential induction of alpha 1-acid glycoprotein and serum amyloid A genes by heavy metals.	SAA1 SAA2	5.13e-06	3	46	2	8357829
Pubmed	Sulf1 and Sulf2 expression in the nervous system and its role in limiting neurite outgrowth in vitro.	SULF2 SULF1	5.13e-06	3	46	2	25448158
Pubmed	Synergy between serum amyloid A and secretory phospholipase A2.	SAA1 SAA2	5.13e-06	3	46	2	31111824
Pubmed	Deficiency of Endogenous Acute-Phase Serum Amyloid A Protects apoE-/- Mice From Angiotensin II-Induced Abdominal Aortic Aneurysm Formation.	SAA1 SAA2	5.13e-06	3	46	2	25745063
Pubmed	Serum Amyloid A Facilitates Early Lesion Development in Ldlr-/- Mice.	SAA1 SAA2	5.13e-06	3	46	2	26187995
Pubmed	Serum Amyloid A is not obligatory for high-fat, high-sucrose, cholesterol-fed diet-induced obesity and its metabolic and inflammatory complications.	SAA1 SAA2	5.13e-06	3	46	2	35436297
Cytoband	Ensembl 112 genes in cytogenetic band chr8q13	XKR9 SULF1	2.67e-03	76	46	2	chr8q13
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	MECOM ZNF112 ZNF473 ZNF658 ZNF268 CASZ1 ZNF829	2.62e-04	718	33	7	28
GeneFamily	FKBP prolyl isomerases	FKBP10 AIP	4.85e-04	18	33	2	910
GeneFamily	Sulfatases	SULF2 SULF1	4.85e-04	18	33	2	410
GeneFamily	EF-hand domain containing	FLG FKBP10 DNAH7	7.32e-03	219	33	3	863
GeneFamily	Ankyrin repeat domain containing	DGKI SHANK2 GABPB2	9.61e-03	242	33	3	403
GeneFamily	PDZ domain containing	SHANK2 PCLO	3.13e-02	152	33	2	1220
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ATP8B3 SAA1 SAA2 NUF2 NNMT	1.33e-06	185	46	5	4d0f3d86fab02c80093e62cb0c79c586c13c5412
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DGKI SULF2 SHANK2 NNMT DNAH7	1.44e-06	188	46	5	af740fa78542438fdff627ea1f74f4eee43316be
ToppCell	COVID-19-Epithelial_cells-Airway_goblet\|COVID-19 / group, cell type (main and fine annotations)	MECOM PLEKHS1 SAA1 SAA2 SHANK2	1.52e-06	190	46	5	51ca9ef4df3220487152fcf684147730637c7cc1
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MECOM SHANK2 DNAH7 CASZ1 PCLO	1.68e-06	194	46	5	93c68c31e39fa44c1d05d7d4997f4f086da4e738
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	MECOM SHANK2 DNAH7 CASZ1 PCLO	1.68e-06	194	46	5	5eaaa81f4b2535f983c424aaef00077089526a5c
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	MECOM SHANK2 DNAH7 CASZ1 PCLO	1.72e-06	195	46	5	6477e6e7be5bd8eb99119a12ae16334ccddecd43
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MECOM SHANK2 DNAH7 CASZ1 PCLO	1.77e-06	196	46	5	eea66711a16134f86e6c533a5a837ff2e0d7ca7f
ToppCell	Lung_Parenchyma-Severe\|Lung_Parenchyma / Location, Disease Group, Cell group, Cell class (2021.03.09)	FKBP10 SAA1 SAA2 SULF2 NNMT	1.95e-06	200	46	5	62502bb23ca732daed32c838ce9719093f3aaeb0
ToppCell	Posterior_cortex-Endothelial-MURAL-M1(Rgs5Acta2)-M1_2-Kcnj8\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	SAA1 SAA2 HMCN2 IQUB	5.67e-06	113	46	4	0651fb7a7e1ea84b8365059e5ed85bf6c082da1a
ToppCell	Posterior_cortex-Endothelial-MURAL-M1(Rgs5Acta2)-M1_2-Kcnj8-MURAL_Mural.Acta2Rgs5.Kcnj8-Abcc9_(Mural.Acta2Rgs5.Kcnj8-Abcc9)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	SAA1 SAA2 HMCN2 IQUB	5.67e-06	113	46	4	0e153efddd061d7510dfc3859cc8b1a7984fa70e
ToppCell	Posterior_cortex-Endothelial-MURAL-M1(Rgs5Acta2)-M1_2\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	SAA1 SAA2 HMCN2 NNMT	1.15e-05	135	46	4	e908aacb72a8c340f06cf5b4a6b70c2faac4d027
ToppCell	COVID-19-Epithelial_cells-Airway_mucous\|COVID-19 / group, cell type (main and fine annotations)	MECOM PLEKHS1 SHANK2 DNAH7	1.78e-05	151	46	4	8216462e723fec2797387929dde095370947e10a
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SAA1 NNMT DNAH7 DAPP1	1.88e-05	153	46	4	499670e716fc85ce76630fc813cec86f8419f2a1
ToppCell	cellseq2-Epithelial-Epithelial_Airway-Secretory/RAS\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SAA1 SAA2 XKR9 ZNF658	2.84e-05	170	46	4	b62f7184e78e9672ea88e361654f604f9df2dc5f
ToppCell	cellseq2-Epithelial-Epithelial_Airway-Secretory/RAS-Secretory\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SAA1 SAA2 XKR9 ZNF658	2.84e-05	170	46	4	00fe77bca9c28762212c498f9c49e14cb1492cca
ToppCell	11.5-Distal-Mesenchymal-Mesenchyme_SERPINF1-high\|Distal / Age, Tissue, Lineage and Cell class	DGKI GRIN2B SULF1 IQUB	3.04e-05	173	46	4	6989c9cebcd81eccceac7e5a86152676ee959386
ToppCell	wk_20-22-Endothelial-Blood_vessel_endothelial-OMD+_endo\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	MECOM HMCN2 NNMT SULF1	3.25e-05	176	46	4	52af8f717dbd3b59eeb868b8b7b256a8f3e57d7a
ToppCell	facs-Trachea-24m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l6-17\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ZDBF2 ZNF112 SHANK2 LCORL	3.32e-05	177	46	4	8abdf1d970b2f15e17e185f3e612dd5065c88757
ToppCell	wk_15-18-Endothelial-Blood_vessel_endothelial-OMD+_endo\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	MECOM HMCN2 NNMT SULF1	3.47e-05	179	46	4	8c9ed247e1c4d655b81ce2f24a9936a7cade718a
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MECOM GRIN2B SHANK2 IQUB	3.55e-05	180	46	4	023ec0b080c8a5cd0f36e83c6b17d4be3c01edb5
ToppCell	3'-Pediatric_IBD-SmallIntestine-Mesenchymal-fibroblastic-mLTo\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SAA1 SAA2 NNMT SULF1	3.55e-05	180	46	4	d1c52aeceb3627e3c5fb6cc3af77e0400f9380ab
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_low-phase\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SAA1 SAA2 NNMT DAPP1	3.62e-05	181	46	4	e0c46e2d52c97893e5894a51d2699e8a8a11eefc
ToppCell	3'-Child04-06-SmallIntestine-Mesenchymal-fibroblastic-Stromal_4_(MMP1+)\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SAA1 SAA2 NNMT SULF1	3.78e-05	183	46	4	269afec240a756eec3bbae5f30ec784281af3433
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_G2M\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ATP8B3 SAA2 NUF2 NNMT	3.86e-05	184	46	4	4b864c74e2cf7e58d6bd151f955c43d72f035d52
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	DGKI MECOM CASZ1 IQUB	3.95e-05	185	46	4	3d73b3e0bceb192257e5cfbe64b7ccb379b6e22d
ToppCell	LA-01._Fibroblast_I\|World / Chamber and Cluster_Paper	UGGT2 HMCN2 NNMT SULF1	4.11e-05	187	46	4	4ea486991f66c29728d127171a07b81404ec0b78
ToppCell	moderate-Lymphoid-NK\|Lymphoid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	FKBP10 HSPA12A NNMT SULF1	4.29e-05	189	46	4	22a19365782003c18ec8dddcdbfdaa82c4e330f6
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MECOM GRIN2B CASZ1 IQUB	4.38e-05	190	46	4	11d3c31167ea71809b4cc3757a0c6ea54a448602
ToppCell	356C-Epithelial_cells-Epithelial-F_(Ciliated)-\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	PLEKHS1 SAA1 SAA2 DNAH7	4.47e-05	191	46	4	dad675251e129254955eac179c84a641a4864586
ToppCell	LV-02._Fibroblast_II\|World / Chamber and Cluster_Paper	MECOM UGGT2 NNMT SULF1	4.47e-05	191	46	4	d36565257ccba8c1bbed2c1c01be66a9cbb5f834
ToppCell	5'-Parenchyma_lung-Mesenchymal-Fibro-meso-mesothelial_cell-Mesothelium-Mesothelium_L.2.6.1.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FKBP10 ETNPPL NNMT SULF1	4.47e-05	191	46	4	b7713aba839e7a1f548b7b9d8893067bcc6d7ee7
ToppCell	Control-Epithelial-Ciliated_cells\|Control / Condition, Lineage and Cell class	MECOM PLEKHS1 SAA2 DNAH7	4.47e-05	191	46	4	ea1d2c6838119b7019e9a2ff71d6212262b51b57
ToppCell	356C-Epithelial_cells-Epithelial-F_(Ciliated)\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	PLEKHS1 SAA1 SAA2 DNAH7	4.47e-05	191	46	4	6d2cf41ee946137c039ddcc13593fc3f670afbba
ToppCell	Control-Epithelial\|Control / Condition, Lineage and Cell class	MECOM PLEKHS1 SAA2 DNAH7	4.47e-05	191	46	4	6228302febdb3dffe37dece7062d27ac9ccc6d4b
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SAA1 SAA2 DNAH7 IQUB	4.56e-05	192	46	4	1b6cac8156e608061e1405e36e18d185b6fa8f6f
ToppCell	LA\|World / Chamber and Cluster_Paper	SAA1 HMCN2 NNMT SULF1	4.65e-05	193	46	4	d4bf89437216baf489ea0239136dcedf3b6714af
ToppCell	LV-01._Fibroblast_I\|LV / Chamber and Cluster_Paper	MECOM UGGT2 NNMT SULF1	4.65e-05	193	46	4	dc17f3b9758936d428cf17f77a1ce6d4c479b165
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Degenerative_Fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FKBP10 HMCN2 NNMT SULF1	4.65e-05	193	46	4	dc8e62df6121ee99b156aca6b1b3ae555739b6f2
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SHANK2 DNAH7 CASZ1 PCLO	4.65e-05	193	46	4	82e8a4c40299ffcdfd5a0da711bb9de6fb8a2eaa
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Degenerative_Fibroblast-Degenerative_Fibroblast_119\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FKBP10 HMCN2 NNMT SULF1	4.65e-05	193	46	4	e2ee077fd381bd906e6b4329f22e7d106e422a7f
ToppCell	(5)_Epithelial_cells-(5)_Epi_basal\|(5)_Epithelial_cells / Oesophagus cell shreds on cell class (v1) and cell subclass (v1)	FKBP10 PLEKHS1 SAA1 NNMT	4.75e-05	194	46	4	b887b2ff19b76bd93c67f9a24762efae816efd45
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	NPC1 MECOM SHANK2 CASZ1	4.75e-05	194	46	4	97534c8bba895a7913665e03ae4e5c4a6ad71daf
ToppCell	5'-Parenchyma_lung-Mesenchymal-Fibro-meso-mesothelial_cell-Mesothelium-Mesothelium_L.2.6.0.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FKBP10 HSPA12A NNMT SULF1	4.75e-05	194	46	4	421344cc4b601d9745fa72d0af3124dab11d1d27
ToppCell	LV-02._Fibroblast_II\|LV / Chamber and Cluster_Paper	MECOM UGGT2 NNMT SULF1	4.75e-05	194	46	4	014d2feb5db2a6a35ef759761a41e466e108c3c1
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SAA1 SAA2 DNAH7 IQUB	4.75e-05	194	46	4	4a2c127c90d1fefe604fcb9e796577d21b489dd6
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_2_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	FKBP10 HMCN2 NNMT SULF1	4.84e-05	195	46	4	ff0aa455e9844a6d7ae57ff59fb6cea825cf1fc2
ToppCell	Mesenchymal_cells-Stromal_fibro.\|World / Lineage and Cell class	SAA1 SAA2 GRIN2B SULF1	4.84e-05	195	46	4	69723b06c2a5c2aaf4d10874b11bca7f06822bdc
ToppCell	normal_Lung-Epithelial_cells-Club\|normal_Lung / Location, Cell class and cell subclass	MECOM PLEKHS1 SAA1 SAA2	4.84e-05	195	46	4	b46544ad5af04f4dbc2643637caa3d2d50d922ae
ToppCell	Bronchial-NucSeq-Epithelial-Epi_airway_secretory\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	MECOM PLEKHS1 SHANK2 CASZ1	4.84e-05	195	46	4	e7230a849ea31e6eef9bc6f5468938499450582d
ToppCell	LA-02._Fibroblast_II\|World / Chamber and Cluster_Paper	UGGT2 HMCN2 NNMT SULF1	4.84e-05	195	46	4	a78b605b49acd8c9d68716266ca269dafcd910b9
ToppCell	E12.5-Mesenchymal-mesenchymal_fibroblast-mesenchymal_alveolar_niche_cell\|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	FKBP10 MECOM SULF2 SULF1	4.84e-05	195	46	4	febe746099964b9ea9e75f2efc72c962c01f0421
ToppCell	NS-moderate-d_07-13-Epithelial-Ciliated-diff\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	SAA1 SAA2 DNAH7 IQUB	4.94e-05	196	46	4	9a91a6e5f93ce3bb5a0fc63677553f4c2df95c43
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SHANK2 DNAH7 CASZ1 PCLO	4.94e-05	196	46	4	6ce74aa3f0ce3ca284b67e5a4660ffd2cc9611e0
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DGKI GRIN2B SHANK2 PCLO	4.94e-05	196	46	4	676c56b44ac29f7baecb62f49bb8597cc74c0a88
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-Layer_VI_Pan-area\|World / Primary Cells by Cluster	HSPA12A GRIN2B LCORL PCLO	5.04e-05	197	46	4	79b9e7f2e8e33b3c547f716be5667156c48b0dfc
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MECOM SHANK2 NNMT DNAH7	5.04e-05	197	46	4	7e93a97b5ac5ae2f77a4b3141082a1463fed00dd
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	HSPA12A SHANK2 DNAH7 IQUB	5.04e-05	197	46	4	74a2c6cb8fcfe53dd9a2b36492a16c58f38e51c9
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-Layer_VI_Pan-area-33\|World / Primary Cells by Cluster	HSPA12A GRIN2B LCORL PCLO	5.04e-05	197	46	4	d20f29088e9afd8a960d6f680075c380e550f8a7
ToppCell	Fibroblasts-DKK3+_Fibroblasts\|World / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues	FKBP10 HMCN2 NNMT SULF1	5.14e-05	198	46	4	4f4632f26a2043c5e4ab89031b4229b5dca1bd48
ToppCell	Somatosensory_Cortex_(S1)-Neuronal\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DGKI GRIN2B SHANK2 PCLO	5.14e-05	198	46	4	c01091ef18e096d792ea2a7a715764a5b215355f
ToppCell	primary_auditory_cortex_(A1C)-Neuronal\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DGKI GRIN2B SHANK2 PCLO	5.14e-05	198	46	4	6d18b45eda4014759e6dd282d78ffd28df8a6044
ToppCell	3'-Pediatric_IBD-SmallIntestine-Mesenchymal-fibroblastic-Stromal_4_(MMP1+)\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FKBP10 SAA1 SAA2 NNMT	5.14e-05	198	46	4	229588189825b1080181db9515185677b742c668
ToppCell	Fetal_29-31_weeks-Epithelial-club_cell-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	MECOM PLEKHS1 SHANK2 PCLO	5.14e-05	198	46	4	6ba5e5970109a04ed968bac7ff099ae250c579dc
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DGKI GRIN2B SHANK2 PCLO	5.14e-05	198	46	4	0ff30edfd3c133a42e8cb96e1631a1143215f808
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DGKI GRIN2B SHANK2 PCLO	5.14e-05	198	46	4	4ca5ff320905ab4ff60ed90a5522227c782142a6
ToppCell	medial-2-Endothelial-Artery\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	MECOM SULF2 NNMT SULF1	5.24e-05	199	46	4	53c17c0493f82351a039bc64def191311e0f4951
ToppCell	medial-Endothelial-Artery-2\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	MECOM SULF2 NNMT SULF1	5.24e-05	199	46	4	c455f5a2802f2ec6f0e24266de1aaf3203ca8c78
ToppCell	Tracheal-10x5prime-Epithelial-Epi_submucosal-gland-SMG_Duct\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	PLEKHS1 SAA1 SAA2 SHANK2	5.24e-05	199	46	4	ef1a0c278c23614fd6a3218a9733abe6ecd6f686
ToppCell	Bronchial-10x5prime-Endothelial-Endothelia_vascular-VE_systemic_arterial\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	MECOM SULF2 NNMT SULF1	5.24e-05	199	46	4	6a2943a23fdd2ec814662db7c21a0d6804a6cbbc
ToppCell	distal-2-Endothelial-Artery\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	MECOM SULF2 NNMT SULF1	5.24e-05	199	46	4	fa8aaf7a90699e41a7a4cee5614f8c9248110327
ToppCell	medial-Endothelial-Artery\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	MECOM SULF2 NNMT SULF1	5.24e-05	199	46	4	341c0be18bec66f4cc8bda232dce54edb34b9cda
ToppCell	distal-Endothelial-Artery-2\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	MECOM SULF2 NNMT SULF1	5.24e-05	199	46	4	3788f3218356aaaa10684e48d63757037f8a3a3c
ToppCell	Parenchymal-10x3prime_v2-Epithelial-Epi_airway_basal-Dividing_Basal\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	PLEKHS1 SAA1 SAA2 NUF2	5.24e-05	199	46	4	f0c289523957258d16135c04679db379d43d28d9
ToppCell	Lung_Parenchyma-Severe-Mesenchymal-Mesenchymal-Fibroblasts-4\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	FKBP10 SULF2 NNMT SULF1	5.34e-05	200	46	4	8256511b099c3eab8e33194f90c9ff354e7cfe8e
ToppCell	metastatic_Brain-Fibroblasts-FB-like_cells\|Fibroblasts / Location, Cell class and cell subclass	FKBP10 SULF2 NNMT SULF1	5.34e-05	200	46	4	f62833c63f9c6a94b6cc2ba8e2f960e67f093f48
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW08-Neuronal-Intermediate\|GW08 / Sample Type, Dataset, Time_group, and Cell type.	MECOM HSPA12A YPEL2 ZNF829	5.34e-05	200	46	4	401d50fa394fa863fa7836344110ae5c7af3250a
ToppCell	Parenchymal-10x5prime-Endothelial-Endothelia_vascular-VE_pulmonary_arterial\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	MECOM SULF2 NNMT SULF1	5.34e-05	200	46	4	ac6b8bc9998d303f788511b8f111e682ea9f3df8
ToppCell	Lung_Parenchyma-Severe-Mesenchymal-Mesenchymal-Fibroblasts-4-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FKBP10 SULF2 NNMT SULF1	5.34e-05	200	46	4	4dbe21cb63569f28c7017cda065ea5ee00d7254e
ToppCell	Neuronal\|World / cells hierarchy compared to all cells using T-Statistic	DGKI GRIN2B SHANK2 PCLO	5.34e-05	200	46	4	48d801219bc771d6c7e151dc88ca4c179988de85
ToppCell	Parenchyma_COVID-19-Stromal-TX-Fibroblasts-4\|Parenchyma_COVID-19 / Sample group, Lineage and Cell type	FKBP10 SULF2 NNMT SULF1	5.34e-05	200	46	4	bde938e5a18844fb8cc1d1be5a086809f7e2b97d
ToppCell	Bronchus_Control_(B.)-Epithelial-TX\|Bronchus_Control_(B.) / Sample group, Lineage and Cell type	PLEKHS1 SAA1 SAA2 DNAH7	5.34e-05	200	46	4	f5bc7d30aa03dd0f95eb64255bd1a2543be8d327
ToppCell	Hippocampus-Endothelial-MURAL-M1(Rgs5Acta2)-M1_2-MURAL_Mural.Rgs5Acta2.Kcnj8_(Mural.Rgs5Acta2.Kcnj8)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	SAA1 SAA2 HMCN2	1.14e-04	91	46	3	78e2e65beb15bf1e251974c72fbcfab817492772
ToppCell	Hippocampus-Endothelial-MURAL-M1(Rgs5Acta2)-M1_2-MURAL_Mural.Rgs5Acta2.Kcnj8_(Mural.Rgs5Acta2.Kcnj8)-\|Hippocampus / BrainAtlas - Mouse McCarroll V32	SAA1 SAA2 HMCN2	1.14e-04	91	46	3	f59908093416ca7b3ca27019d71c79acbdea18cb
ToppCell	Hippocampus-Endothelial-MURAL-M1(Rgs5Acta2)-M1_2\|Hippocampus / BrainAtlas - Mouse McCarroll V32	SAA1 SAA2 HMCN2	1.14e-04	91	46	3	104d2ab9fe5cc404388c32fafb34e421c2e138be
ToppCell	Frontal_cortex-Endothelial-MURAL-M1(Rgs5Acta2)-M1_2-MURAL_Mural.Rgs5Acta2.Abcc9_(Mural.Rgs5Acta2.Abcc9)\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	SAA1 SAA2 HMCN2	1.60e-04	102	46	3	72ce247dad7404e6b9c971b5c29d3c6846da5efc
ToppCell	Frontal_cortex-Endothelial-MURAL-M1(Rgs5Acta2)-M1_2-MURAL_Mural.Rgs5Acta2.Abcc9_(Mural.Rgs5Acta2.Abcc9)-\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	SAA1 SAA2 HMCN2	1.60e-04	102	46	3	8c4d9483ff983538593f4e17f4a74a93cdda59c4
ToppCell	Frontal_cortex-Endothelial-MURAL-M1(Rgs5Acta2)-M1_2\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	SAA1 SAA2 HMCN2	1.60e-04	102	46	3	5feedce6d26a578c4aaba4e4824b3d0c3f3806bc
ToppCell	Striatum-Endothelial-MURAL-M1(Rgs5Acta2)-M1_2\|Striatum / BrainAtlas - Mouse McCarroll V32	SAA1 SAA2 HMCN2	2.11e-04	112	46	3	88fcd0dc12b5c00804381fb7dd59a6a2a9f37419
ToppCell	Striatum-Endothelial-MURAL-M1(Rgs5Acta2)-M1_2-MURAL_Mural.Rgs5Acta2.Kcnj8_(Mural.Rgs5Acta2.Kcnj8)-\|Striatum / BrainAtlas - Mouse McCarroll V32	SAA1 SAA2 HMCN2	2.11e-04	112	46	3	fd4cc5190626cb262aae0a7f04559b0e9757270e
ToppCell	Striatum-Endothelial-MURAL-M1(Rgs5Acta2)-M1_2-MURAL_Mural.Rgs5Acta2.Kcnj8_(Mural.Rgs5Acta2.Kcnj8)\|Striatum / BrainAtlas - Mouse McCarroll V32	SAA1 SAA2 HMCN2	2.11e-04	112	46	3	d652e6fae433a6b56bf2a448fba2cf6c5e558905
ToppCell	Entopeduncular-Endothelial-MURAL-M1(Rgs5Acta2)-M1_2-MURAL_Mural.Rgs5Acta2.Kcnj8_(Mural.Rgs5Acta2.Kcnj8)-\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	SAA1 SAA2 NNMT	2.46e-04	118	46	3	3cebd17f4688cd43fe1283dc60957e87d5536810
ToppCell	Entopeduncular-Endothelial-MURAL-M1(Rgs5Acta2)-M1_2-MURAL_Mural.Rgs5Acta2.Kcnj8_(Mural.Rgs5Acta2.Kcnj8)\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	SAA1 SAA2 NNMT	2.46e-04	118	46	3	71f63efc641cd07c870f7695118fb244929c1536
ToppCell	Entopeduncular-Endothelial-MURAL-M1(Rgs5Acta2)-M1_2\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	SAA1 SAA2 NNMT	2.46e-04	118	46	3	61b00b001edb1954a5fffaf4dfe71708124a45e5
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	MECOM GRIN2B IQUB	2.52e-04	119	46	3	0cebbd44378c212aa0e18e4303f09eb315d02e11
ToppCell	Bronchial_Biopsy-Epithelial-Ciliated_2\|Bronchial_Biopsy / Tissue, Lineage and Cell class of Lung Cells from 10X	SAA2 WDR64 DAPP1	3.05e-04	127	46	3	508b188ccbe5aa6ec0128c443aedb5a8ea35a6d0
ToppCell	Bronchial_Biopsy-Epithelial-Ciliated_2\|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X	SAA2 WDR64 DAPP1	3.27e-04	130	46	3	04ad0542210e7a8c8d4d9d0bfd83de2629bc3176
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Transitional_Principal-Intercalated_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DGKI PLEKHS1 CASZ1	3.34e-04	131	46	3	d706405453408fbcfcabb1c7702b80f9e649ffca
ToppCell	Cerebellum-Endothelial-MURAL-M1(Rgs5Acta2)-M1_2\|Cerebellum / BrainAtlas - Mouse McCarroll V32	SAA1 SAA2 HMCN2	3.81e-04	137	46	3	9324b55eac55e0cc1e8e450a4b5374d12e9587a3
ToppCell	PND01-03-samps-Mesenchymal-Myofibroblast-myofibroblast_-_mature_-_DCN\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	HMCN2 NNMT SULF1	3.81e-04	137	46	3	a69976938d4e89315ec0be3a332b91ddf3799d65
ToppCell	Cerebellum-Endothelial-MURAL-M1(Rgs5Acta2)-M1_2-MURAL_Mural.Acta2Rgs5.Kcnj8_(Mural.Acta2Rgs5.Kcnj8)\|Cerebellum / BrainAtlas - Mouse McCarroll V32	SAA1 SAA2 HMCN2	3.81e-04	137	46	3	032f8409d0d179e254c8ff632afbda78852a9889
Disease	serum amyloid A protein measurement	SAA1 SAA2	3.40e-05	6	45	2	EFO_0004728
Disease	NRF2 measurement	NUF2 GRIN2B	6.33e-05	8	45	2	EFO_0009794
Disease	illegal drug consumption	WDR64 LCORL	1.76e-04	13	45	2	EFO_0005431
Disease	nicotine dependence symptom count, depressive symptom measurement	SULF2 GRIN2B PCLO	2.07e-04	75	45	3	EFO_0007006, EFO_0009262
Disease	serum amyloid A-1 protein measurement	SAA1 SAA2	3.43e-04	18	45	2	EFO_0008282
Disease	citrulline measurement	MECOM HMCN2	4.25e-04	20	45	2	EFO_0009777
Disease	cardiovascular disease	NPC1 MECOM LCORL ZNF268 CASZ1	6.40e-04	457	45	5	EFO_0000319
Disease	Lewy body dementia, Lewy body dementia measurement	SAA1 SAA2	7.22e-04	26	45	2	EFO_0006792, EFO_0006799
Disease	Barrett's esophagus	GRIN2B HMCN2	8.38e-04	28	45	2	EFO_0000280
Disease	mean arterial pressure, unipolar depression	MECOM CASZ1	1.10e-03	32	45	2	EFO_0003761, EFO_0006340
Disease	unipolar depression, systolic blood pressure	MECOM CASZ1	1.24e-03	34	45	2	EFO_0003761, EFO_0006335
Disease	rosacea severity measurement	SAA1 SAA2 PCLO	1.47e-03	147	45	3	EFO_0009180
Disease	urate measurement	ATP8B3 MECOM UGGT2 DNAJC13 AIP SHANK2	2.27e-03	895	45	6	EFO_0004531
Disease	systolic blood pressure, alcohol consumption measurement	MECOM CASZ1	2.35e-03	47	45	2	EFO_0006335, EFO_0007878
Disease	waist-hip ratio	NPC1 MECOM GRIN2B XKR9 LCORL ZNF268 IQUB	2.39e-03	1226	45	7	EFO_0004343
Disease	urate measurement, bone density	UGGT2 WDR64 UBE4B SULF1 CASZ1	2.44e-03	619	45	5	EFO_0003923, EFO_0004531
Disease	vital capacity	MECOM XKR9 GABPB2 LCORL SULF1 CASZ1 PCLO	2.50e-03	1236	45	7	EFO_0004312
Disease	mean arterial pressure, alcohol consumption measurement	MECOM CASZ1	2.87e-03	52	45	2	EFO_0006340, EFO_0007878
Disease	diastolic blood pressure, alcohol consumption measurement	MECOM CASZ1	3.09e-03	54	45	2	EFO_0006336, EFO_0007878
Disease	body composition measurement	HMCN2 XKR9 LCORL	3.19e-03	193	45	3	EFO_0005106
Disease	cortical surface area measurement	DGKI MECOM DNAJC13 SULF2 XKR9 LCORL DNAH7	4.00e-03	1345	45	7	EFO_0010736

Protein segments in the cluster

Peptide	Gene	Start	Entry
KSYHIKDDAYAKDGF	CASZ1	631	Q86V15
GFSVKEFKDHHYYLS	ATP8B3	401	O60423
KASAFGKDHPRYYAT	FLG	4016	P20930
GKYREDHADSASAYA	ETNPPL	176	Q8TBG4
REGHVKEAAAKYYDA	AIP	191	O00170
YKEEEYKSGLSALDH	MECOM	1126	Q03112
HVRDYRKYSEDGSFK	LNP1	81	A1A4G5
YVFSDARAKDYHKKE	HMCN2	136	Q8NDA2
KTRDFHDSYSYKDSK	LCORL	326	Q8N3X6
ADTSYRHFPKSEKYS	PCLO	4151	Q9Y6V0
EKYHDGIEKAAEDSY	NUF2	431	Q9BZD4
LEKYYKFGSRHSAES	NNMT	21	P40261
DYYKKFRGHSVEHAL	HSPA12A	411	O43301
AKLAGDHIEYYKASS	OXA1L	186	Q15070
DHKKGDDFFVYADYH	NPC1	496	O15118
EKHADYIASYGSKKD	RABGGTB	21	P53611
EEKHAYFAHARKVYE	CRNKL1	386	Q9BZJ0
RYHYNGTFEDGKKFD	FKBP10	66	Q96AY3
YEGFHYDKEKLREAS	DGKI	736	O75912
AKDSVKHFHVEYTGY	DAPP1	76	Q9UN19
HKVTGDATFAYTKYE	DNAH7	1156	Q8WXX0
KTYGSEFVYSDHAKE	DNAJC13	1671	O75165
GKYFSAAEYHAQRLK	IQUB	326	Q8NA54
YGADVHAFSKFDKSA	GABPB2	126	Q8TAK5
KGHDKAVLDSYEYFA	MRPS10	81	P82664
HKYFEESFKAYERGI	XAB2	531	Q9HCS7
DKYFHARGNYDAAKR	SAA2	51	P0DJI9
DKYFHARGNYDAAKR	SAA1	51	P0DJI8
KLFRHYTVGSYDSFD	SHANK2	601	Q9UPX8
TKNGHVYKYDGFRES	SSRP1	66	Q08945
AGEKSFSLSYYKDHH	PLEKHS1	46	Q5SXH7
SEFGTYYVDHTNKKA	SAV1	246	Q9H4B6
HGKSLKYIDFTSDYA	ZNF268	206	Q14587
GATSEFYDKFTIRYH	UBE4B	981	O95155
KSYKLGDFDVSYASH	ZDBF2	1401	Q9HCK1
RIHFGEKHYESKEYG	ZNF829	176	Q3KNS6
EKHYESKEYGKSFSR	ZNF829	181	Q3KNS6
EKSYEHGENAKAFSY	ZNF658	186	Q5TYW1
EHAFESSQKYKEGKY	YPEL2	91	Q96QA6
RVHSSDKFYKSEDYG	ZNF112	881	Q9UJU3
HSKYDEERKAGASFY	UGGT2	596	Q9NYU1
KHGFDYAKDYFTDLI	SULF1	181	Q8IWU6
EKHGSDYSKDYLTDL	SULF2	181	Q8IWU5
HKEDAIGYDKFYASV	WDR64	46	B1ANS9
LKRGYHAAFKYDSNT	XKR9	96	Q5GH70
AKSKEYRGEFFSYSD	ZNF473	181	Q8WTR7
KFSFKSDRYSGHDDL	GRIN2B	1041	Q13224