Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	cytoplasmic vesicle membrane	MON2 PIKFYVE GAD2 MFGE8 MALRD1 AP2A1 AP2A2 UBR4 SPIRE1 ASPSCR1 PCSK4 DOP1B EHD4 EPHB1	7.85e-05	1307	69	14	GO:0030659
GeneOntologyCellularComponent	vesicle membrane	MON2 PIKFYVE GAD2 MFGE8 MALRD1 AP2A1 AP2A2 UBR4 SPIRE1 ASPSCR1 PCSK4 DOP1B EHD4 EPHB1	9.08e-05	1325	69	14	GO:0012506
GeneOntologyCellularComponent	endosome	MON2 PIKFYVE JAK2 AP2A1 AP2A2 UBR4 VPS8 TNF SIGLEC1 DOP1B EHD4 EPHB1	3.98e-04	1167	69	12	GO:0005768
GeneOntologyCellularComponent	early endosome membrane	MON2 PIKFYVE DOP1B EHD4 EPHB1	6.79e-04	212	69	5	GO:0031901
GeneOntologyCellularComponent	AP-2 adaptor complex	AP2A1 AP2A2	9.52e-04	14	69	2	GO:0030122
GeneOntologyCellularComponent	early endosome	MON2 PIKFYVE VPS8 SIGLEC1 DOP1B EHD4 EPHB1	1.03e-03	481	69	7	GO:0005769
GeneOntologyCellularComponent	clathrin coat of endocytic vesicle	AP2A1 AP2A2	1.10e-03	15	69	2	GO:0030128
GeneOntologyCellularComponent	secretory granule	PIKFYVE QSOX1 MFGE8 AP2A1 AP2A2 GHDC UBR4 TNF PCSK4 MYO5C	1.74e-03	1014	69	10	GO:0030141
GeneOntologyCellularComponent	filopodium tip	AP2A1 EPHB1	1.96e-03	20	69	2	GO:0032433
GeneOntologyCellularComponent	endolysosome membrane	AP2A1 AP2A2	1.96e-03	20	69	2	GO:0036020
GeneOntologyCellularComponent	clathrin coat of coated pit	AP2A1 AP2A2	2.17e-03	21	69	2	GO:0030132
Domain	-	AP2A1 AP2A2	1.27e-05	2	67	2	2.60.40.1030
Domain	AP2_complex_asu	AP2A1 AP2A2	1.27e-05	2	67	2	IPR017104
Domain	Clathrin_a-adaptin_app_sub_C	AP2A1 AP2A2	1.27e-05	2	67	2	IPR003164
Domain	Clathrin_a-adaptin_app_Ig-like	AP2A1 AP2A2	1.27e-05	2	67	2	IPR013038
Domain	Alpha_adaptin_C	AP2A1 AP2A2	1.27e-05	2	67	2	PF02296
Domain	-	AP2A1 AP2A2	7.57e-05	4	67	2	3.30.310.30
Domain	Clathrin_a/coatomer_app_sub_C	AP2A1 AP2A2	7.57e-05	4	67	2	IPR015873
Domain	Coatomer/calthrin_app_sub_C	AP2A1 AP2A2	3.50e-04	8	67	2	IPR009028
Domain	Clathrin_a/b/g-adaptin_app_Ig	AP2A1 AP2A2	4.49e-04	9	67	2	IPR008152
Domain	Alpha_adaptinC2	AP2A1 AP2A2	4.49e-04	9	67	2	PF02883
Domain	Alpha_adaptinC2	AP2A1 AP2A2	4.49e-04	9	67	2	SM00809
Domain	Coatomer/clathrin_app_Ig-like	AP2A1 AP2A2	8.18e-04	12	67	2	IPR013041
Domain	Clathrin/coatomer_adapt-like_N	AP2A1 AP2A2	1.29e-03	15	67	2	IPR002553
Domain	Adaptin_N	AP2A1 AP2A2	1.29e-03	15	67	2	PF01602
Domain	-	MFGE8 PCSK4 EPHB1	2.29e-03	73	67	3	2.60.120.260
Domain	ARM-like	MON2 SETX PSME4 AP2A1 AP2A2	2.83e-03	270	67	5	IPR011989
Domain	Galactose-bd-like	MFGE8 PCSK4 EPHB1	4.69e-03	94	67	3	IPR008979
Pubmed	Cytoplasmic Metadherin (MTDH) provides survival advantage under conditions of stress by acting as RNA-binding protein.	MFGE8 NEO1 AP2A1 GHDC MNT DOP1B EPHB1	2.61e-07	214	70	7	22199357
Pubmed	Essential roles for the splicing regulator nSR100/SRRM4 during nervous system development.	MON2 NEO1 AP2A1 DYNC2H1	4.54e-07	31	70	4	25838543
Pubmed	TNFα facilitates clonal expansion of JAK2V617F positive cells in myeloproliferative neoplasms.	JAK2 TNF	3.99e-06	2	70	2	21860020
Pubmed	Cloning of cDNAs encoding two related 100-kD coated vesicle proteins (alpha-adaptins).	AP2A1 AP2A2	3.99e-06	2	70	2	2564002
Pubmed	Autocrine Tnf signaling favors malignant cells in myelofibrosis in a Tnfr2-dependent fashion.	JAK2 TNF	3.99e-06	2	70	2	29749399
Pubmed	Dengue virus co-opts UBR4 to degrade STAT2 and antagonize type I interferon signaling.	UBR4 STAT2	3.99e-06	2	70	2	23555265
Pubmed	Expression of pigment epithelium-derived factor and tumor necrosis factor-α is correlated in bladder tumor and is related to tumor angiogenesis.	SERPINF1 TNF	3.99e-06	2	70	2	21292512
Pubmed	The UGT2A1/UGT2A2 locus is associated with COVID-19-related loss of smell or taste.	UGT2A1 UGT2A2	3.99e-06	2	70	2	35039640
Pubmed	Association of TNF polymorphisms with JAK2 (V617F) myeloproliferative neoplasms in Brazilian patients.	JAK2 TNF	3.99e-06	2	70	2	26852656
Pubmed	Cloning, physical mapping and structural characterization of the human alpha(A)-adaptin gene.	AP2A1 AP2A2	3.99e-06	2	70	2	12036598
Pubmed	Rat olfactory bulb and epithelium UDP-glucuronosyltransferase 2A1 (UGT2A1) expression: in situ mRNA localization and quantitative analysis.	UGT2A1 UGT2A2	3.99e-06	2	70	2	11376859
Pubmed	CD169⁺ macrophages provide a niche promoting erythropoiesis under homeostasis and stress.	JAK2 SIGLEC1	3.99e-06	2	70	2	23502962
Pubmed	Cloning and characterization of a novel human olfactory UDP-glucuronosyltransferase.	UGT2A1 UGT2A2	3.99e-06	2	70	2	10359671
Pubmed	Antagonistic functions of Dishevelleds regulate Frizzled3 endocytosis via filopodia tips in Wnt-mediated growth cone guidance.	AP2A1 AP2A2 EPHB1	4.29e-06	16	70	3	24305805
Pubmed	Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.	UBE4B UBR4 NOL6 TFIP11 STAT2 DARS2 EHD4	5.78e-06	341	70	7	32971831
Pubmed	KAP1 facilitates reinstatement of heterochromatin after DNA replication.	U2AF1 AP2A1 UBE4B POLE UBR4 NOL6 DARS2 DPH6 EHD4	1.17e-05	704	70	9	29955894
Pubmed	FABP4 activates the JAK2/STAT2 pathway via Rap1a in the homocysteine-induced macrophage inflammatory response in ApoE-/- mice atherosclerosis.	JAK2 STAT2	1.20e-05	3	70	2	34725437
Pubmed	Clathrin-independent endocytic retrieval of SV proteins mediated by the clathrin adaptor AP-2 at mammalian central synapses.	AP2A1 AP2A2	1.20e-05	3	70	2	35014951
Pubmed	A diacidic motif in human immunodeficiency virus type 1 Nef is a novel determinant of binding to AP-2.	AP2A1 AP2A2	1.20e-05	3	70	2	18032517
Pubmed	Roquin-2 shares functions with its paralog Roquin-1 in the repression of mRNAs controlling T follicular helper cells and systemic inflammation.	RC3H2 TNF	1.20e-05	3	70	2	23583642
Pubmed	Tumour necrosis factor-alpha attenuates insulin action on phosphoenolpyruvate carboxykinase gene expression and gluconeogenesis by altering the cellular localization of Foxa2 in HepG2 cells.	TNF FOXA2	1.20e-05	3	70	2	19769745
Pubmed	Spire1 and Myosin Vc promote Ca2+-evoked externalization of von Willebrand factor in endothelial cells.	SPIRE1 MYO5C	1.20e-05	3	70	2	35084586
Pubmed	CYP2C8-derived epoxyeicosatrienoic acids decrease oxidative stress-induced endothelial apoptosis in development of atherosclerosis: Role of Nrf2 activation.	CYP2C8 TNF	1.20e-05	3	70	2	26489615
Pubmed	AP2 adaptor complex mediates bile salt export pump internalization and modulates its hepatocanalicular expression and transport function.	AP2A1 AP2A2	1.20e-05	3	70	2	22262466
Pubmed	Envelope Glycoprotein Internalization Protects Human and Simian Immunodeficiency Virus-Infected Cells from Antibody-Dependent Cell-Mediated Cytotoxicity.	AP2A1 AP2A2	1.20e-05	3	70	2	26269175
Pubmed	Direct stimulation of Jak/STAT pathway by the angiotensin II AT1 receptor.	JAK2 STAT2	1.20e-05	3	70	2	7746328
Pubmed	A basic patch on alpha-adaptin is required for binding of human immunodeficiency virus type 1 Nef and cooperative assembly of a CD4-Nef-AP-2 complex.	AP2A1 AP2A2	1.20e-05	3	70	2	19129443
Pubmed	The Human UDP-glucuronosyltransferase UGT2A1 and UGT2A2 enzymes are highly active in bile acid glucuronidation.	UGT2A1 UGT2A2	1.20e-05	3	70	2	23756265
Pubmed	Interaction of Shc with adaptor protein adaptins.	AP2A1 AP2A2	1.20e-05	3	70	2	8617812
Pubmed	Breast cancer cells promote CD169+ macrophage-associated immunosuppression through JAK2-mediated PD-L1 upregulation on macrophages.	JAK2 SIGLEC1	1.20e-05	3	70	2	31865052
Pubmed	TNF-alpha acts via p38 MAPK to stimulate expression of the ubiquitin ligase atrogin1/MAFbx in skeletal muscle.	TNF FBXO32	1.20e-05	3	70	2	15746179
Pubmed	JAK2/STAT2/STAT3 are required for myogenic differentiation.	JAK2 STAT2	1.20e-05	3	70	2	18835816
Pubmed	Human UDP-glucuronosyltransferase UGT2A2: cDNA construction, expression, and functional characterization in comparison with UGT2A1 and UGT2A3.	UGT2A1 UGT2A2	1.20e-05	3	70	2	19858781
Pubmed	The ear of alpha-adaptin interacts with the COOH-terminal domain of the Eps 15 protein.	AP2A1 AP2A2	1.20e-05	3	70	2	8662627
Pubmed	A Jak2 inhibitor, AG490, reverses lipin-1 suppression by TNF-alpha in 3T3-L1 adipocytes.	JAK2 TNF	1.20e-05	3	70	2	19281795
Pubmed	Mon2, a relative of large Arf exchange factors, recruits Dop1 to the Golgi apparatus.	MON2 DOP1B	1.20e-05	3	70	2	16301316
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	MON2 PIKFYVE JAK2 CCDC88C PSME4 AP2A1 UBE4B POLE UBR4 SPIRE1 KIFC2	1.23e-05	1105	70	11	35748872
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	ABCC1 AP2A1 GHDC UBE4B DYNC2H1 POLE UBR4 TNF ADGRL2 DARS2	1.85e-05	942	70	10	31073040
Pubmed	TRIM10 binds to IFN-α/β receptor 1 to negatively regulate type I IFN signal transduction.	STAT2 TRIM10	2.39e-05	4	70	2	33811647
Pubmed	Zika virus spreads through infection of lymph node-resident macrophages.	SIGLEC1 STAT2	2.39e-05	4	70	2	36795561
Pubmed	Disruption of the murine Ap2β1 gene causes nonsyndromic cleft palate.	AP2A1 AP2A2	2.39e-05	4	70	2	20500056
Pubmed	miR-135b-5p promotes gastric carcinogenesis by targeting CLIP4-mediated JAK2/STAT3 signal pathway.	CLIP4 JAK2	2.39e-05	4	70	2	39121973
Pubmed	Leptin induces the expression of functional tissue factor in human neutrophils and peripheral blood mononuclear cells through JAK2-dependent mechanisms and TNFalpha involvement.	JAK2 TNF	2.39e-05	4	70	2	18308368
Pubmed	The B cell coreceptor CD22 associates with AP50, a clathrin-coated pit adapter protein, via tyrosine-dependent interaction.	AP2A1 AP2A2	2.39e-05	4	70	2	12646615
Pubmed	Association and colocalization of Eps15 with adaptor protein-2 and clathrin.	AP2A1 AP2A2	2.39e-05	4	70	2	9049247
Pubmed	The transcription factor gene Nfib is essential for both lung maturation and brain development.	NEO1 NFIX ROBO2	3.05e-05	30	70	3	15632069
Pubmed	A protein-protein interaction map of the TNF-induced NF-κB signal transduction pathway.	AP2A1 AP2A2 DYNC2H1 NOL6 ROBO2 TNF	3.35e-05	302	70	6	30561431
Pubmed	SRSF2 and U2AF1 mutations in primary myelofibrosis are associated with JAK2 and MPL but not calreticulin mutation and may independently reoccur after allogeneic stem cell transplantation.	JAK2 U2AF1	3.98e-05	5	70	2	25231745
Pubmed	Nomenclature update for the mammalian UDP glycosyltransferase (UGT) gene superfamily.	UGT2A1 UGT2A2	3.98e-05	5	70	2	16141793
Pubmed	Interaction of HIV-1 Gag with the clathrin-associated adaptor AP-2.	AP2A1 AP2A2	3.98e-05	5	70	2	16139856
Pubmed	Endocytic Adaptor Proteins in Health and Disease: Lessons from Model Organisms and Human Mutations.	AP2A1 AP2A2	3.98e-05	5	70	2	31671891
Pubmed	SNX3-retromer requires an evolutionary conserved MON2:DOPEY2:ATP9A complex to mediate Wntless sorting and Wnt secretion.	MON2 DOP1B	3.98e-05	5	70	2	30213940
Pubmed	Weak Molecular Interactions in Clathrin-Mediated Endocytosis.	AP2A1 AP2A2	3.98e-05	5	70	2	29184887
Pubmed	A conserved dileucine motif mediates clathrin and AP-2-dependent endocytosis of the HIV-1 envelope protein.	AP2A1 AP2A2	3.98e-05	5	70	2	17108326
Pubmed	Epsin is an EH-domain-binding protein implicated in clathrin-mediated endocytosis.	AP2A1 AP2A2	3.98e-05	5	70	2	9723620
Pubmed	Analysis of the AP-2 adaptor complex and cargo during clathrin-mediated endocytosis.	AP2A1 AP2A2	3.98e-05	5	70	2	15941406
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	SETX NFIX POLE UBR4 TSHZ1 FOXA2 ADGRL2 MNT DARS2	5.45e-05	857	70	9	25609649
Pubmed	Numb expression and asymmetric versus symmetric cell division in distal embryonic lung epithelium.	AP2A1 AP2A2	5.96e-05	6	70	2	22713487
Pubmed	Clathrin.	AP2A1 AP2A2	5.96e-05	6	70	2	10966473
Pubmed	The JAK/STAT pathway is not sufficient to sustain the antiproliferative response in an interferon-resistant human melanoma cell line.	JAK2 STAT2	5.96e-05	6	70	2	12777975
Pubmed	HIV-1 Tat enters T cells using coated pits before translocating from acidified endosomes and eliciting biological responses.	AP2A1 AP2A2	5.96e-05	6	70	2	15020715
Pubmed	Calcyon, a mammalian specific NEEP21 family member, interacts with adaptor protein complex 3 (AP-3) and regulates targeting of AP-3 cargoes.	AP2A1 AP2A2	5.96e-05	6	70	2	22650988
Pubmed	LECT2 drives haematopoietic stem cell expansion and mobilization via regulating the macrophages and osteolineage cells.	TNF SIGLEC1	5.96e-05	6	70	2	27596364
Pubmed	The mu2 subunit of the clathrin adaptor AP-2 binds to FDNPVY and YppØ sorting signals at distinct sites.	AP2A1 AP2A2	5.96e-05	6	70	2	12121421
Pubmed	Molecular architecture and functional model of the endocytic AP2 complex.	AP2A1 AP2A2	5.96e-05	6	70	2	12086608
Pubmed	Cytokine-stimulated GTP cyclohydrolase I expression in endothelial cells requires coordinated activation of nuclear factor-kappaB and Stat1/Stat3.	JAK2 TNF	5.96e-05	6	70	2	15604419
Pubmed	Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins.	QSOX1 ABCC1 MFGE8 AP2A1 AP2A2 UBR4 SLC22A17	6.60e-05	499	70	7	22810586
Pubmed	C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.	MON2 PIKFYVE NEO1 VPS8 ADGRL2 FAM83B DOP1B	7.02e-05	504	70	7	34432599
Pubmed	Clathrin interacts specifically with amphiphysin and is displaced by dynamin.	AP2A1 AP2A2	8.33e-05	7	70	2	9280305
Pubmed	The structure, regulation and function of the Janus kinases (JAKs) and the signal transducers and activators of transcription (STATs).	JAK2 STAT2	8.33e-05	7	70	2	9342212
Pubmed	Beta-NAP, a cerebellar degeneration antigen, is a neuron-specific vesicle coat protein.	AP2A1 AP2A2	8.33e-05	7	70	2	7671305
Pubmed	Human immunodeficiency virus Nef induces rapid internalization of the T-cell coreceptor CD8alphabeta.	AP2A1 AP2A2	8.33e-05	7	70	2	16103193
Pubmed	Endocytosis of synaptic ADAM10 in neuronal plasticity and Alzheimer's disease.	AP2A1 AP2A2	8.33e-05	7	70	2	23676497
Pubmed	JAK/STAT signaling by cytokine receptors.	JAK2 STAT2	8.33e-05	7	70	2	9638363
Pubmed	Alpha-AP-2 directs myosin VI-dependent endocytosis of cystic fibrosis transmembrane conductance regulator chloride channels in the intestine.	AP2A1 AP2A2	8.33e-05	7	70	2	20351096
Pubmed	STAP-2/BKS, an adaptor/docking protein, modulates STAT3 activation in acute-phase response through its YXXQ motif.	JAK2 STAT2	8.33e-05	7	70	2	12540842
Pubmed	Bone marrow CD169+ macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche.	TNF SIGLEC1	8.33e-05	7	70	2	21282381
Pubmed	A non-proteolytic role for ubiquitin in deadenylation of MHC-I mRNA by the RNA-binding E3-ligase MEX-3C.	AP2A1 AP2A2 NOL6	9.75e-05	44	70	3	26471122
Pubmed	Gene essentiality and synthetic lethality in haploid human cells.	SECISBP2L PIKFYVE AP2A1 AP2A2 UBE4B	1.01e-04	229	70	5	26472760
Pubmed	Serine phosphorylation-independent downregulation of cell-surface CD4 by nef.	AP2A1 AP2A2	1.11e-04	8	70	2	2014052
Pubmed	Neutrophil ageing is regulated by the microbiome.	TNF SIGLEC1	1.11e-04	8	70	2	26374999
Pubmed	Mis-expression of L1 on pre-crossing spinal commissural axons disrupts pathfinding at the ventral midline.	GAD2 EPHB1	1.11e-04	8	70	2	17884558
Pubmed	Floor plate-derived neuropilin-2 functions as a secreted semaphorin sink to facilitate commissural axon midline crossing.	GAD2 FOXA2	1.11e-04	8	70	2	26680304
Pubmed	Decreased synaptic vesicle recycling efficiency and cognitive deficits in amphiphysin 1 knockout mice.	AP2A1 AP2A2	1.11e-04	8	70	2	11879655
Pubmed	Accessory protein recruitment motifs in clathrin-mediated endocytosis.	AP2A1 AP2A2	1.42e-04	9	70	2	12057195
Pubmed	The chemokine SDF-1alpha triggers CXCR4 receptor dimerization and activates the JAK/STAT pathway.	JAK2 STAT2	1.42e-04	9	70	2	10506573
Pubmed	Pioneer midbrain longitudinal axons navigate using a balance of Netrin attraction and Slit repulsion.	ROBO2 FOXA2	1.42e-04	9	70	2	25056828
Pubmed	BAL1/ARTD9 represses the anti-proliferative and pro-apoptotic IFNγ-STAT1-IRF1-p53 axis in diffuse large B-cell lymphoma.	JAK2 STAT2	1.42e-04	9	70	2	23487038
Pubmed	Doublecortin interacts with mu subunits of clathrin adaptor complexes in the developing nervous system.	AP2A1 AP2A2	1.42e-04	9	70	2	11591131
Pubmed	Tlx3 Exerts Direct Control in Specifying Excitatory Over Inhibitory Neurons in the Dorsal Spinal Cord.	ROBO2 ADGRL2	1.78e-04	10	70	2	33996801
Pubmed	Cytokines, Jaks, Stats, health and disease.	JAK2 STAT2	1.78e-04	10	70	2	10200816
Pubmed	Interferon-dependent IL-10 production by Tregs limits tumor Th17 inflammation.	TNF STAT2	1.78e-04	10	70	2	24216477
Pubmed	CALM regulates clathrin-coated vesicle size and maturation by directly sensing and driving membrane curvature.	AP2A1 AP2A2	1.78e-04	10	70	2	25898166
Pubmed	HIV-1 Nef-induced down-regulation of MHC class I requires AP-1 and clathrin but not PACS-1 and is impeded by AP-2.	AP2A1 AP2A2	1.78e-04	10	70	2	17581864
Pubmed	JAK-STAT and bone metabolism.	JAK2 STAT2	1.78e-04	10	70	2	24069548
Pubmed	A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.	ABCC1 AP2A1 LRRC49 ROBO2 ADGRL2 FAM83B	2.07e-04	421	70	6	36976175
Pubmed	Genetic susceptibility to carbamazepine-induced cutaneous adverse drug reactions.	CYP2C8 TNF	2.17e-04	11	70	2	16538176
Pubmed	Nef, the shuttling molecular adaptor of HIV, influences the cytokine network.	TNF STAT2	2.17e-04	11	70	2	25529283
Pubmed	HIV-1 Assembly at the Plasma Membrane: Gag Trafficking and Localization.	AP2A1 AP2A2	2.17e-04	11	70	2	19802344
Pubmed	Haploinsufficiency in the ANKS1B gene encoding AIDA-1 leads to a neurodevelopmental syndrome.	AP2A1 AP2A2	2.17e-04	11	70	2	31388001
Coexpression	GSE29615_CTRL_VS_LAIV_FLU_VACCINE_PBMC_DN	CLIP4 MON2 UBQLNL TSHZ1 TNF DARS2	1.04e-05	191	68	6	M4924
ToppCell	tumor_Lymph_Node_/_Brain-Myeloid_cells-pDCs\|Myeloid_cells / Location, Cell class and cell subclass	ADGRG5 POLE SERPINF1 OVOS2 EPHB1	4.74e-06	156	70	5	19472ef1642c2ad333aa3ce3675a25c6ab1d4556
ToppCell	368C-Myeloid-Dendritic-pDC\|Dendritic / Donor, Lineage, Cell class and subclass (all cells)	MYO15B POLE NOL6 DOP1B EPHB1	7.41e-06	171	70	5	f3bf5805823d5733b58742172e7668725ce82931
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	CAPN14 DYNC2H1 ADGRL2 MYO5C FAM83B	1.14e-05	187	70	5	f124d2c699b717b7c02a1a70493f515b83dc2f4c
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	CAPN14 DYNC2H1 ADGRL2 MYO5C FAM83B	1.20e-05	189	70	5	e32172ad09e93f6ac6ea2b92145b2b73003f7970
ToppCell	COVID-19_Severe-Non-classical_Monocyte-\|COVID-19_Severe / Disease condition and Cell class	CLIP4 CCDC88C CYRIA AP2A1 TNF	1.36e-05	194	70	5	d70b9039fd2fef3e4be086513b94fb7e9bc1f670
ToppCell	COVID-19_Severe-Non-classical_Monocyte\|COVID-19_Severe / Disease condition and Cell class	CLIP4 CCDC88C CYRIA AP2A1 TNF	1.36e-05	194	70	5	5151546812678ae85cb22224084d27b29e3c4724
ToppCell	5'-Adult-LargeIntestine-Epithelial-goblet\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	QSOX1 ANO7 FOXA2 MYO5C DOP1B	1.43e-05	196	70	5	847b3377f463bfded046eec63cc1b547f3dc33c1
ToppCell	5'-Adult-LargeIntestine-Epithelial-goblet-BEST2+_Goblet_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	QSOX1 ANO7 FOXA2 MYO5C DOP1B	1.47e-05	197	70	5	d624f3a105b19f19a0dd253ce8de3ed13adc1f01
ToppCell	BAL-Mild-cDC_1\|Mild / Compartment, Disease Groups and Clusters	JAK2 QSOX1 SETX SIGLEC1 STAT2	1.54e-05	199	70	5	c55181bdec8952b54198f0d4c9c5c84265b16572
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW16\|fetalBrain_Zhong_nature / Sample Type, Dataset, Time_group, and Cell type.	NFIX SPIRE1 ROBO2 ADGRL2 DOP1B	1.58e-05	200	70	5	fd6b4ff4330db11c03f1eb4e06b43a162326f744
ToppCell	LPS_IL1RA-Mesenchymal_myocytic-Myofibroblastic\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	NFIX SERPINF1 ROBO2 TSHZ1 FBXO32	1.58e-05	200	70	5	87827041663013f5e7273168dc8709d69840e7ce
ToppCell	LPS-IL1RA-Hematopoietic_Mast-Mast_cells-Mast-cells\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	LRRC63 ADGRG5 ABCC1 PCSK4	6.83e-05	139	70	4	f1d1a51a79afdddc82e73cd29b3240e3e973db28
ToppCell	facs-Large_Intestine-Distal-3m-Epithelial-Goblet_cell,_top_of_crypt_(Distal)\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	QSOX1 DPY19L2 MYO5C DOP1B	8.71e-05	148	70	4	f58804d24fe524b42b5090c8658050ea4b14793e
ToppCell	LPS-IL1RA+antiTNF-Myeloid-Dendritic_cells\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ADGRG5 TNF SIGLEC1 EPHB1	9.90e-05	153	70	4	c81a88d3f707487c511020d3960a1c41e706c6a0
ToppCell	IIH-CD8-memory_CD4\|IIH / Condition, Cell_class and T cell subcluster	ABCC1 UBQLNL NEO1 NOL6	1.07e-04	156	70	4	e312fc4317d966fb2b570d1a4a3aa865f781ea93
ToppCell	tumor_Lymph_Node_/_Brain-Myeloid_cells-pDCs\|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass	ADGRG5 SERPINF1 OVOS2 EPHB1	1.12e-04	158	70	4	2af7beb48272e5368d9ba6b80f08d47ab8556c08
ToppCell	5'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SERPINF1 UGT2A2 OVOS2 ROBO2	1.21e-04	161	70	4	7c9d4410d7142a5f3a05418c994f69978c9ffa17
ToppCell	droplet-Marrow-BM-30m-Myeloid-basophil\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CYRIA UBR4 SIGLEC1 KIFC2	1.23e-04	162	70	4	75df7ff779a3b9159ba97d852da1f8df650b9ce5
ToppCell	PND07-28-samps-Epithelial-Epithelial-non_alveolar-Club_cell\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	UGT2A1 UGT2A2 FOXA2 MYO5C	1.23e-04	162	70	4	aed15eef32419b8a4e2afdb9776c2bf2802e96f1
ToppCell	facs-Brain_Non-Myeloid-Cerebellum_-18m-Neuronal-SPN_Neuron_STR\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLIP4 CCDC88C GAD2 ZIM3	1.32e-04	165	70	4	1b7dfa173e83aa8c46a3153a3261866c065c3b73
ToppCell	droplet-Liver-HEPATOCYTES-1m-Epithelial-Hepatocyte_(Pericentral_and_Periportal)\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	QSOX1 SERPINF1 CPN2 FOXA2	1.32e-04	165	70	4	d449a568664a81d9b5538e8f409301448a32ac37
ToppCell	facs-Brain_Non-Myeloid-Cerebellum_-18m-Neuronal-medium_spiny_neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLIP4 CCDC88C GAD2 ZIM3	1.32e-04	165	70	4	b4f7d33af7d053ec07b01bd67d861600a9c4822e
ToppCell	PND28-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	QSOX1 SERPINF1 TRIM10 EPHB1	1.39e-04	167	70	4	f01b96173deda0239fa482989873cf308e49d48c
ToppCell	368C-Myeloid-Dendritic-pDC\|368C / Donor, Lineage, Cell class and subclass (all cells)	MYO15B POLE DOP1B EPHB1	1.39e-04	167	70	4	1e2fc1637769405a61f4c7e44945712a1888a299
ToppCell	PND28-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	QSOX1 SERPINF1 TRIM10 EPHB1	1.39e-04	167	70	4	5fc85a05124cd2324e1b8ff940193880f83cd8af
ToppCell	(3)_MNP-(3)_DC_plasmacytoid\|(3)_MNP / Lung cell shreds - cell class (v4) and cell subclass (v4)	ADGRG5 UBQLNL SERPINF1 EPHB1	1.42e-04	168	70	4	13c160ea1a19b47d2e7e2dae818c8dcde4e3e377
ToppCell	10x5'v1-week_17-19-Myeloid_neutrophil-granulo-neutrophil-promyelocyte\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	NEO1 UBR4 ANO7 KIFC2	1.45e-04	169	70	4	f33f4a0baad1b3cb5be61dfc7b00c7a3845f7120
ToppCell	Basal_cells-SSc-ILD_02\|World / lung cells shred on cell class, cell subclass, sample id	MALRD1 POLE SERPINF1 FBXO32	1.49e-04	170	70	4	776d4224a682b6c648041827efd69794f88906f0
ToppCell	368C-Myeloid-Dendritic-pDC\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	MYO15B POLE DOP1B EPHB1	1.52e-04	171	70	4	714a0b0d0c9886fef64170cf53eb64f0d8a47280
ToppCell	390C-Myeloid-Dendritic-pDC\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	ADGRG5 SERPINF1 PCSK4 EPHB1	1.55e-04	172	70	4	3f894c74916d49a995b2d4651ca1c6733c14ce9c
ToppCell	Club-club-3\|World / Class top	QSOX1 SERPINF1 FOXA2 MYO5C	1.55e-04	172	70	4	34fbb82a2ec77dd183cf26b38edeb7e936b707bc
ToppCell	pdx-Tumor_cells-T2\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	ADGRG5 ROBO2 STAT2 DPH6	1.70e-04	176	70	4	1e21f80cf0e695ffdd63e4a72cf1e3fa41b60341
ToppCell	390C-Myeloid-Dendritic-pDC\|Dendritic / Donor, Lineage, Cell class and subclass (all cells)	ADGRG5 FBXO32 PCSK4 EPHB1	1.70e-04	176	70	4	aab9603b7943b7f7243eb6190ebba998566196f3
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_epithelium-respiratory_basal_cell-Basal_resting-Basal_resting_L.0.0.0.3\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SERPINF1 FBXO32 FOXA2 SLC22A17	1.73e-04	177	70	4	8c6d8a1c469346e66f9095d86b4615f8fc611362
ToppCell	nucseq-Epithelial-Epithelial_Airway-Basal/Suprabasal\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SERPINF1 UGT2A1 FBXO32 FAM83B	1.73e-04	177	70	4	cbad1a23851151dbef01ea2af960e6f0944f838b
ToppCell	nucseq-Epithelial-Epithelial_Airway-Basal/Suprabasal-Basal\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SERPINF1 UGT2A1 FBXO32 FAM83B	1.73e-04	177	70	4	ce86dfaeb74d995a19aea62f0fb15c4c0bb854b0
ToppCell	LV\|World / Chamber and Cluster_Paper	DPY19L2 VPS8 FBXO32 ADGRL2	1.85e-04	180	70	4	5ac6f485a58bb29462fec02dfbe8eb70864eafe3
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CCDC88C DPY19L2 SPIRE1 ADGRL2	1.93e-04	182	70	4	f96095b81188b52db8fcfca4837129cfcd9bd7b7
ToppCell	E18.5-samps-Mesenchymal-Myofibroblast\|E18.5-samps / Age Group, Lineage, Cell class and subclass	SPIRE1 ROBO2 TSHZ1 FBXO32	1.97e-04	183	70	4	de08f9ea02b7244d5a8788064631d10f06565337
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CCDC88C DPY19L2 SPIRE1 ROBO2	1.97e-04	183	70	4	b5ede5a0048c585b73c00e88aeddbcaf669347b1
ToppCell	LPS_only-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SERPINF1 ROBO2 TSHZ1 FBXO32	1.97e-04	183	70	4	12daaea821e49bc94a01e2496331e92a80d27339
ToppCell	facs-Large_Intestine-Distal-3m-Epithelial\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	QSOX1 FBXO32 FOXA2 MYO5C	2.05e-04	185	70	4	fd1911b57927c03470f9387962ca9581e5643fb3
ToppCell	facs-Large_Intestine-Distal-3m\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	QSOX1 FBXO32 FOXA2 MYO5C	2.05e-04	185	70	4	7a18d525de6f874924bfc61b9666b307da86421a
ToppCell	Control-Epithelial-Basal\|Epithelial / Disease state, Lineage and Cell class	ABCC1 SERPINF1 UGT2A1 FAM83B	2.05e-04	185	70	4	d5d6d13e2f20b54ca55645b9a757b8599f4fd897
ToppCell	tumor_Lung-Myeloid_cells-pDCs\|Myeloid_cells / Location, Cell class and cell subclass	ADGRG5 U2AF1 SERPINF1 EPHB1	2.10e-04	186	70	4	3d7c1a281fb82db4471283f39937007d889a5f38
ToppCell	10x_3'_v3-tissue-resident_(10x_3'_v3)-hematologic\|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	CYP2C8 NFIX CPN2 TRIM10	2.14e-04	187	70	4	edb0ab0154542b1c0b3a2c216c4a60f0f06290b3
ToppCell	facs-Large_Intestine-Distal-18m-Epithelial\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	QSOX1 FBXO32 MYO5C EHD4	2.14e-04	187	70	4	ab109aa51beae3df474c15002e70361f328cadad
ToppCell	normal_Lung-Myeloid_cells-pDCs\|Myeloid_cells / Location, Cell class and cell subclass	ADGRG5 UBQLNL MYO15B TSHZ1	2.14e-04	187	70	4	a3592f056e1c2f82ba325fea2ecc4dd6c6347c81
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SPIRE1 ADGRL2 MYO5C FAM83B	2.14e-04	187	70	4	77886f99c229610abd28c4c370d2c7d1536c9782
ToppCell	normal_Lung-Myeloid_cells-pDCs\|normal_Lung / Location, Cell class and cell subclass	ADGRG5 UBQLNL MYO15B TSHZ1	2.14e-04	187	70	4	d36751372fd40a46441f07735c9c3c5dcb503f24
ToppCell	facs-Large_Intestine-Distal-18m\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	QSOX1 FBXO32 MYO5C EHD4	2.14e-04	187	70	4	a4c408fc941d2e8a811a26aa916c0b3e3341163a
ToppCell	(0)_Myeloid-(011)_pDC\|(0)_Myeloid / immune cells in Peripheral Blood (logTPM normalization)	ADGRG5 SERPINF1 PCSK4 EPHB1	2.18e-04	188	70	4	a81b5d840490d6a636fe168f8cff2c4984369f09
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	JAK2 MFGE8 NFIX ROBO2	2.23e-04	189	70	4	127ad2ba3e794df8cce2eee3e4171bccb5aad51b
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	JAK2 MFGE8 NFIX ROBO2	2.23e-04	189	70	4	2cfb4d12f75678d1619f4743838a0e954bd57761
ToppCell	10x_3'_v3-tissue-resident_(10x_3'_v3)-hematologic-erythrocytic\|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	CYP2C8 NFIX CPN2 TRIM10	2.23e-04	189	70	4	7899af78b273d9c7f029d52f7e0cf6df4da41f5e
ToppCell	facs-Large_Intestine-Distal\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	QSOX1 FBXO32 FOXA2 MYO5C	2.27e-04	190	70	4	3964a8390522b61b73235151bb0a2ff36b856867
ToppCell	10x_3'_v3-tissue-resident_(10x_3'_v3)-hematologic-erythrocytic-erythrocyte\|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	CYP2C8 NFIX CPN2 TRIM10	2.27e-04	190	70	4	a34293601aefe5fb5c400c14091294b9ddaa195b
ToppCell	5'-GW_trimst-2-SmallIntestine-Epithelial-goblet\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ANO7 FOXA2 MYO5C DOP1B	2.41e-04	193	70	4	402aad2f9e789ad1f2e1536cdc9ce61de7625427
ToppCell	5'-GW_trimst-2-SmallIntestine-Epithelial-goblet-Goblet_cell\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ANO7 FOXA2 MYO5C DOP1B	2.41e-04	193	70	4	7ee3b1ef5c455f321b4e154ae62c69543fe9b30e
ToppCell	3'-Child04-06-SmallIntestine-Epithelial-goblet-Goblet_cell\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	QSOX1 ANO7 FOXA2 MYO5C	2.46e-04	194	70	4	49cc5f5de4380302100e8cd937f08abe317ac75e
ToppCell	3'-Adult-LargeIntestine-Epithelial-goblet\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	QSOX1 MYO15B ANO7 FBXO32	2.46e-04	194	70	4	1a188e52f2f0b6eca3e8d4a4671d9beab0fbbb88
ToppCell	facs-Brain_Non-Myeloid-Striatum-3m\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLIP4 SECISBP2L GAD2 SLC22A17	2.46e-04	194	70	4	ba529c051f248d29f4222f4bc9801ba233859093
ToppCell	3'-Child04-06-SmallIntestine-Epithelial-goblet\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	QSOX1 ANO7 FOXA2 MYO5C	2.46e-04	194	70	4	fb935df966c451e659b8bde281f8aebcb632f6cf
ToppCell	BL-critical-LOC-Epithelial-Basal\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	NFIX SERPINF1 UGT2A1 FAM83B	2.46e-04	194	70	4	2932f704656ca368565ec12f3452af3b18e8df12
ToppCell	5'-GW_trimst-2-LargeIntestine-Epithelial-goblet-Goblet_cell\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ANO7 FOXA2 MYO5C DOP1B	2.51e-04	195	70	4	7ff04c45a02df01e3816f3c1d43585a93182a730
ToppCell	5'-Adult-SmallIntestine-Epithelial-Tuft-related-BEST4+_epithelial\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	JAK2 QSOX1 MYO15B MALRD1	2.51e-04	195	70	4	e87b11e3242fdbed2e7f383e6876ec375af32bd4
ToppCell	human_hepatoblastoma-Inflammatory_Monocytes\|human_hepatoblastoma / Sample and Cell Type and Tumor Cluster (all cells)	CLIP4 CYRIA SPIRE1 SIGLEC1	2.51e-04	195	70	4	ba7f85e5307d96ac5ad7c952f8d094db9ca1790c
ToppCell	3'-Adult-LargeIntestine-Epithelial-goblet-BEST2+_Goblet_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	QSOX1 MYO15B ANO7 FBXO32	2.51e-04	195	70	4	3365768101454060b9ea96ef6b426c76c150bc8f
ToppCell	5'-GW_trimst-2-LargeIntestine-Epithelial-goblet\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ANO7 FOXA2 MYO5C DOP1B	2.51e-04	195	70	4	09605533aa5947bb2e5a6725c1ce89f79d330bf5
ToppCell	3'-Child09-12-SmallIntestine-Epithelial-goblet\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	QSOX1 ANO7 MYO5C DOP1B	2.56e-04	196	70	4	c2d17630f7bfc9e727de55e093c17fddac61b61f
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW08-Myeloid-Microglia\|GW08 / Sample Type, Dataset, Time_group, and Cell type.	RPS6KA3 SERPINF1 TNF EHD4	2.56e-04	196	70	4	89a0ccd0684777927d99d5fc5b7c498f3f124250
ToppCell	COVID-19_Severe-Non-classical_Monocyte\|COVID-19_Severe / disease group, cell group and cell class	CLIP4 CYRIA AP2A1 TNF	2.56e-04	196	70	4	af9e8f5ef9d03862f707e105857309b55595b1b9
ToppCell	facs-Brain_Non-Myeloid-Cortex\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NEO1 SPIRE1 SLC22A17 EPHB1	2.56e-04	196	70	4	256fe9bc0815f66a9afe11ba3507ef1372b52fd3
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW08-Myeloid\|GW08 / Sample Type, Dataset, Time_group, and Cell type.	RPS6KA3 SERPINF1 TNF EHD4	2.56e-04	196	70	4	91a8c4798572d6c1f03cef5e8e5464ed0046c7cf
ToppCell	3'-Child09-12-SmallIntestine-Epithelial-goblet-Goblet_cell\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	QSOX1 ANO7 MYO5C DOP1B	2.56e-04	196	70	4	54c30023d04e7265373647f56fc93885804938b0
ToppCell	10x5'v1-week_17-19-Mesenchymal_osteo-stroma-osteoblast\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	SERPINF1 ROBO2 CPN2 SLC22A17	2.56e-04	196	70	4	d5ed41fa111750e6b363c04cccc40a47dd774852
ToppCell	Control_saline-Epithelial_alveolar-AT_2-Differentiating_AT2\|Control_saline / Treatment groups by lineage, cell group, cell type	SECISBP2L ASPSCR1 FOXA2 MYO5C	2.61e-04	197	70	4	44a59dfb889577b3160a5b13ada1276771a00241
ToppCell	distal-1-Hematologic-Plasmacytoid_Dendritic\|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	ADGRG5 UBQLNL SERPINF1 EPHB1	2.61e-04	197	70	4	166d47359df9279ea8c3946f10bd3d4b88c95857
ToppCell	LPS_anti-TNF-Epithelial_alveolar-AT_1-Differentiating_AT2\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	SECISBP2L FOXA2 KIFC2 MYO5C	2.61e-04	197	70	4	3d13a4f2e86422900ee2194e8a1fd1cf9750d5d3
ToppCell	COVID-19_Severe-Non-classical_Monocyte\|World / disease group, cell group and cell class	CLIP4 CYRIA AP2A1 TNF	2.61e-04	197	70	4	60fee75b12451206bb2c07b61651a73c59ec6ade
ToppCell	Control_saline-Epithelial_alveolar-AT_2\|Control_saline / Treatment groups by lineage, cell group, cell type	SECISBP2L ASPSCR1 FOXA2 MYO5C	2.61e-04	197	70	4	b8f62fcd6eb8f47b3cc41f616126f82c68a36e87
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NEO1 SPIRE1 SLC22A17 EPHB1	2.66e-04	198	70	4	a7e5de81eb7d3d23812c179a001adbaab1506596
ToppCell	wk_08-11-Epithelial-Airway_epithelial_progenitor-epi-prox-progenitor_intermediate_\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	SECISBP2L SERPINF1 FOXA2 MYO5C	2.66e-04	198	70	4	1eb49b853a9e144e840c660060473fc7873f6478
ToppCell	LPS_IL1RA-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	ASPSCR1 FOXA2 KIFC2 MYO5C	2.66e-04	198	70	4	b598ab958e31f1e98bd06dc0097b58ac3a3f90a3
ToppCell	5'-Adult-Distal_Rectal\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	QSOX1 MFGE8 NEO1 SERPINF1	2.66e-04	198	70	4	db26c20321f9ab102d6484f22ddb2bde684067b1
ToppCell	LPS_IL1RA_TNF-Hematopoietic_Myeloid-Dendritic_cells\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	ADGRG5 TNF SIGLEC1 EPHB1	2.66e-04	198	70	4	436f3a9ef31b0991765bb97c21960f20fa71d578
ToppCell	LPS_anti-TNF-Mesenchymal_myocytic-Myofibroblastic\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	NFIX SERPINF1 ROBO2 FBXO32	2.71e-04	199	70	4	e9820d5fb4e8b46973c4c50ac5db8fb4a1bf603b
ToppCell	LPS_anti-TNF-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	SERPINF1 ROBO2 TSHZ1 FBXO32	2.71e-04	199	70	4	38cfd367ee8c074c11ba54edeb7a001e375e2687
ToppCell	LPS_IL1RA-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	SERPINF1 ROBO2 TSHZ1 FBXO32	2.71e-04	199	70	4	6b3a0e5d52a30d0eed30e6a670f5b53bc233f70c
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Mesenchymal-immature_mesenchymal_cell\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	QSOX1 MFGE8 NFIX ROBO2	2.71e-04	199	70	4	3cf62666ffd000427fdbb7cf940793f98c3ed29c
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW16\|organoid_Tanaka_cellReport / Sample Type, Dataset, Time_group, and Cell type.	NFIX SPIRE1 ROBO2 DOP1B	2.76e-04	200	70	4	8795920911ee75c09a97cc948c14ad7301b27796
ToppCell	367C-Fibroblasts-Fibroblast-B_(Myofibroblast)-\|367C / Donor, Lineage, Cell class and subclass (all cells)	MFGE8 NFIX SERPINF1 ROBO2	2.76e-04	200	70	4	082e718c1da3f4fdd33a001d15ad3ddb2be985c7
ToppCell	mild\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	JAK2 SETX SIGLEC1 STAT2	2.76e-04	200	70	4	12f1685ce8f218433068e090c9d839cd5a1910bf
ToppCell	LPS_IL1RA_TNF-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	SERPINF1 ROBO2 TSHZ1 FBXO32	2.76e-04	200	70	4	09537dc25f8b8b4654a7c183827ee1522a41a4e0
ToppCell	LPS_anti-TNF-Mesenchymal_myocytic-Myofibroblastic-Myofibroblast\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	NFIX SERPINF1 ROBO2 FBXO32	2.76e-04	200	70	4	c596a53c0b63c9deaac7d99fcbdd94ecfa96b86c
ToppCell	LPS_only-Mesenchymal_myocytic-Myofibroblastic-Myofibroblast\|LPS_only / Treatment groups by lineage, cell group, cell type	SERPINF1 ROBO2 TSHZ1 FBXO32	2.76e-04	200	70	4	593bf6a7c557437db9a9249a5058a46014179ef6
ToppCell	367C-Fibroblasts-Fibroblast-B_(Myofibroblast)\|367C / Donor, Lineage, Cell class and subclass (all cells)	MFGE8 NFIX SERPINF1 ROBO2	2.76e-04	200	70	4	731e55070a7ff315091855bd88cda30e5a7e1a98
ToppCell	LPS_IL1RA_TNF-Mesenchymal_myocytic-Myofibroblastic\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	NFIX SERPINF1 ROBO2 FBXO32	2.76e-04	200	70	4	08bf8c00eee6468215edb3611296bfc8784c4d56
ToppCell	LPS_anti-TNF-Mesenchymal_myocytic\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	MFGE8 SERPINF1 ROBO2 FBXO32	2.76e-04	200	70	4	67dcbd86fbc79fd585d0793f979e4aac100326c9
ToppCell	LPS_only-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast\|LPS_only / Treatment groups by lineage, cell group, cell type	SERPINF1 ROBO2 TSHZ1 FBXO32	2.76e-04	200	70	4	a9ff3210127000b3dd9e97136163c98c2b0817d7
Disease	Abnormality of the sense of smell, COVID-19 symptoms measurement, ageusia	UGT2A1 UGT2A2	5.08e-06	2	67	2	EFO_0600019, EFO_1001758, HP_0004408
Disease	liver cancer (implicated_via_orthology)	JAK2 POLE	3.04e-05	4	67	2	DOID:3571 (implicated_via_orthology)
Disease	quality of life during menstruation measurement, Arthralgia	GAD2 DOP1B	5.06e-05	5	67	2	EFO_0009366, HP_0002829
Disease	VACTERL association (implicated_via_orthology)	QSOX1 DYNC2H1	7.57e-05	6	67	2	DOID:14679 (implicated_via_orthology)
Disease	retinal detachment (implicated_via_orthology)	JAK2 TNF	7.57e-05	6	67	2	DOID:5327 (implicated_via_orthology)
Disease	neutropenia (is_implicated_in)	TNF STAT2	1.41e-04	8	67	2	DOID:1227 (is_implicated_in)
Disease	alcoholic liver cirrhosis (is_marker_for)	JAK2 SERPINF1	1.81e-04	9	67	2	DOID:14018 (is_marker_for)
Disease	lung adenocarcinoma, family history of lung cancer	MALRD1 ROBO2 EPHB1	2.16e-04	51	67	3	EFO_0000571, EFO_0006953
Disease	uveitis (is_marker_for)	SERPINF1 TNF	3.90e-04	13	67	2	DOID:13141 (is_marker_for)
Disease	uveitis (is_implicated_in)	SERPINF1 TNF	3.90e-04	13	67	2	DOID:13141 (is_implicated_in)
Disease	Muscular Atrophy	TNF FBXO32	5.23e-04	15	67	2	C0026846
Disease	Neurogenic Muscular Atrophy	TNF FBXO32	5.23e-04	15	67	2	C0270948
Disease	endometriosis (biomarker_via_orthology)	SERPINF1 TNF	5.97e-04	16	67	2	DOID:289 (biomarker_via_orthology)
Disease	portal hypertension (implicated_via_orthology)	JAK2 TNF	8.47e-04	19	67	2	DOID:10762 (implicated_via_orthology)
Disease	portal hypertension (biomarker_via_orthology)	SERPINF1 TNF	1.14e-03	22	67	2	DOID:10762 (biomarker_via_orthology)
Disease	anogenital venereal wart (is_marker_for)	SERPINF1 TNF	1.59e-03	26	67	2	DOID:11168 (is_marker_for)
Disease	response to norepinephrine-dopamine reuptake inhibitor	ROBO2 FBXO32	1.59e-03	26	67	2	EFO_0007870
Disease	psychosis predisposition measurement	ABCC1 FBXO32	1.59e-03	26	67	2	EFO_0008337
Disease	attention deficit hyperactivity disorder (implicated_via_orthology)	FBXO32 ADGRL2	1.85e-03	28	67	2	DOID:1094 (implicated_via_orthology)
Disease	Hyperinsulinism	TNF FOXA2	1.85e-03	28	67	2	C0020459
Disease	selenium measurement	DYNC2H1 ADGRL2	1.98e-03	29	67	2	EFO_0006331
Disease	Hepatoma, Morris	JAK2 MFGE8 TNF	2.03e-03	110	67	3	C0019207
Disease	Hepatoma, Novikoff	JAK2 MFGE8 TNF	2.03e-03	110	67	3	C0019208
Disease	Experimental Hepatoma	JAK2 MFGE8 TNF	2.03e-03	110	67	3	C0086404
Disease	Liver Neoplasms, Experimental	JAK2 MFGE8 TNF	2.03e-03	110	67	3	C0023904

Protein segments in the cluster

Peptide	Gene	Start	Entry
LSLQWRFANLPNNAK	ASPSCR1	61	Q9BZE9
QAQCRWLNVQLSPQQ	CPN2	496	P22792
QPLAYLWQRNQEDLL	DPH6	136	Q7L8W6
FQRWKQLSLPQQEAQ	AP2A1	876	O95782
FNENFRILNSPWIQV	CYP2C8	201	P10632
NPRDNQLYVWNNNFI	ADGRL2	371	O95490
FAILRQWVPQVQQNI	CLIP4	71	Q8N3C7
QRQLLQDTFWKNPQF	CAPN14	366	A8MX76
DFFQRWKQLSNPQQE	AP2A2	836	O94973
QNPQQLSANLWAAVR	RC3H2	171	Q9HBD1
AELQRNEQEQPLGQW	QSOX1	626	O00391
WNNNVNQRPSFRDLA	JAK2	1106	O60674
IDLATWNFQFLPQVN	PTPN9	241	P43378
QAPRLNQRQVLFQHW	ANO7	306	Q6IWH7
PNQNNWLLTTFINRR	EPHB1	66	P54762
IQNPNDIQLQEKAWN	CYRIA	66	Q9H0Q0
LLQEYNWELADQPQN	GAD2	141	Q05329
RDGNFLNIPQQSQSW	NFIX	486	Q14938
SNDDNPWIQVNLLRR	MFGE8	121	Q08431
HWDQLPQYQLNRQDA	RPS6KA3	681	P51812
PDLSREWQRALNFQQ	DOP1B	1466	Q9Y3R5
LNNAQLELNRWQARF	CCDC88C	1286	Q9P219
AIRQFQPNQINENWK	FAM83B	371	Q5T0W9
NPKVQWFQQQTLQRR	PCSK4	96	Q6UW60
QQQALRWCLQGAQRP	GHDC	66	Q8N2G8
DWKNNPLFVNLNNEL	NOL6	911	Q9H6R4
ARQWDLQQQRVANIA	LRRC49	346	Q8IUZ0
LLEAARFLEWQAQQQ	MNT	6	Q99583
WAQPLQNTDNRRLFE	EHD4	261	Q9H223
WRDNYLNNPQQLTQI	LRRC63	476	Q05C16
LENNWNILQFLPQAA	POLE	1976	Q07864
NQIQLFAPAEWVALN	MON2	1391	Q7Z3U7
LKDPQNNRIFQWQNV	OVOS2	146	Q6IE36
RNQWSIIGEFNNLPQ	DPY19L2	606	Q6NUT2
SQLVAQLWQNPDEQQ	MYO15B	556	Q96JP2
QNTAALPNQWERNVI	MALRD1	176	Q5VYJ5
LQAWNNRLQDLFQQE	PIKFYVE	1501	Q9Y2I7
RNQPAEYRNNLENWI	DYNC2H1	2131	Q8NCM8
NVINNWFQNNRARLP	CPHXL2	66	A0A1W2PPK0
WQQQLNNIQITRPAF	FBXO32	206	Q969P5
FRQPQWQLLDPNATA	SLC22A12	91	Q96S37
QGQQPLQLEEDQRAW	KIFC2	181	Q96AC6
VPQQAWIQNDSLREN	ABCC1	711	P33527
DLFPFYRQNQQRWQN	FOXA2	191	Q9Y261
NQEILPVFLNANRNW	DARS2	396	Q6PI48
WFNLLSPNLQNQQFF	STAT2	471	P52630
VWAQQGNPNRDLNEA	SLC22A17	396	Q8WUG5
NADLVPFVRWEQNRQ	NEO1	176	Q92859
QEWLNSPNRENFYQL	SETX	1761	Q7Z333
SNRQFPLYNNDIRWQ	SECISBP2L	66	Q93073
SHNLNQQQREALWFP	VPS8	1131	Q8N3P4
NNLRDPVNISFWHNQ	ADGRG5	166	Q8IZF4
NFTQGEWQRLNPEQR	ZIM3	16	Q96PE6
GNPRLDLQEINNWVQ	SERPINF1	171	P36955
LRLYNQPINEEQAWA	SPIRE1	46	Q08AE8
WDQLPRDQQQARQSQ	UBE4B	1061	O95155
FWQKEGSQNLLFPNQ	ROBO2	346	Q9HCK4
CLQEQVRLQWQGQDP	SIGLEC1	166	Q9BZZ2
AVIDLNNRWFNGQPI	U2AF1	126	Q01081
QLSEQWRQQLPTFLQ	UBQLNL	451	Q8IYU4
QNLPQWEGQLVNLFA	PSME4	246	Q14997
FAQDLWPENIQNSFQ	ZNF253	81	O75346
PNWQLANVVENIERL	TRIM10	71	Q9UDY6
NNWLRQVLFTPATQA	UBR4	4126	Q5T4S7
GNNTQLFDWIPQNDL	UGT2A1	346	P0DTE4
QLINMVRFQQWNCIP	nan	41	Q499Y3
ITDWDLQNEFNPNRQ	TFIP11	26	Q9UBB9
NWNPQHLLILQAQFA	TSHZ1	891	Q6ZSZ6
PQAEGQLQWLNRRAN	TNF	96	P01375
QLQWLNRRANALLAN	TNF	101	P01375
NNTQLFDWIPQNDLL	UGT2A2	356	P0DTE5
WLQKLYNNFVNRNPL	MYO5C	521	Q9NQX4