Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionscaffold protein binding

KRT5 DSP GRM3 LRP4 CACNA1H KIF5A

1.54e-05931146GO:0097110
GeneOntologyMolecularFunctionlow voltage-gated calcium channel activity

CACNA1I CACNA1H

9.66e-0531142GO:0008332
GeneOntologyMolecularFunctionnucleoside-triphosphatase regulator activity

ARHGEF28 MYO9B ARHGEF5 OBSCN RASAL3 SRGAP3 TBC1D12 ARHGAP28 ARHGEF2 SIPA1L2 AGAP1

1.55e-0450711411GO:0060589
GeneOntologyMolecularFunctionGTPase regulator activity

ARHGEF28 MYO9B ARHGEF5 OBSCN RASAL3 SRGAP3 TBC1D12 ARHGAP28 ARHGEF2 SIPA1L2 AGAP1

1.55e-0450711411GO:0030695
GeneOntologyMolecularFunctionenzyme regulator activity

ARHGEF28 MYO9B ARHGEF5 GAS6 OBSCN PTN RASAL3 WDR6 SRGAP3 TBC1D12 CCNA1 ARHGAP28 LTK ARHGEF2 POLG2 SIPA1L2 ATP2A3 AGAP1 SORL1

4.10e-04141811419GO:0030234
GeneOntologyBiologicalProcessregulation of small GTPase mediated signal transduction

RIPOR2 ARHGEF28 MYO9B ARHGEF5 OBSCN RASAL3 SRGAP3 LRP4 ARHGAP28 ARHGEF2 SIPA1L2

2.03e-0633311211GO:0051056
GeneOntologyBiologicalProcesssmall GTPase-mediated signal transduction

RIPOR2 ARHGEF28 MYO9B ARHGEF5 OBSCN DOK2 RASAL3 SRGAP3 LRP4 ARHGAP28 ARHGEF2 SIPA1L2

3.63e-0553811212GO:0007264
GeneOntologyBiologicalProcessaxon development

SEMA6B ARHGEF28 NRDC LGR4 CRTAC1 PTN EFNB1 PLPPR4 BHLHE22 LRP4 FOXP1 KIF5A GOLGA8A

4.59e-0564211213GO:0061564
GeneOntologyCellularComponentinterstitial matrix

NAV2 KAZALD1 ADAMTSL4

1.04e-04171153GO:0005614
DomainARHGEF5_35

ARHGEF5 ARHGEF35

3.69e-0521142PF15441
DomainARHGEF5/35_N

ARHGEF5 ARHGEF35

3.69e-0521142IPR029212
DomainVDCC_T_a1

CACNA1I CACNA1H

1.10e-0431142IPR005445
Domain-

TDP2 SYNJ2 INPP5J

5.20e-042611433.60.10.10
DomainExo_endo_phos

TDP2 SYNJ2 INPP5J

5.20e-04261143PF03372
DomainEndo/exonuclease/phosphatase

TDP2 SYNJ2 INPP5J

5.82e-04271143IPR005135
DomainDH_1

ARHGEF28 ARHGEF5 OBSCN ARHGEF2

5.94e-04631144PS00741
DomainZF_DAG_PE_1

ARHGEF28 MYO9B TNS2 ARHGEF2

6.31e-04641144PS00479
DomainZF_DAG_PE_2

ARHGEF28 MYO9B TNS2 ARHGEF2

6.31e-04641144PS50081
DomainC1

ARHGEF28 MYO9B TNS2 ARHGEF2

6.69e-04651144SM00109
DomainPE/DAG-bd

ARHGEF28 MYO9B TNS2 ARHGEF2

7.09e-04661144IPR002219
DomainSIX1_SD

SIX3 SIX6

7.60e-0471142IPR031701
DomainSIX1_SD

SIX3 SIX6

7.60e-0471142PF16878
DomainRhoGEF

ARHGEF28 ARHGEF5 OBSCN ARHGEF2

7.94e-04681144SM00325
DomainRhoGEF

ARHGEF28 ARHGEF5 OBSCN ARHGEF2

8.85e-04701144PF00621
DomainDH_2

ARHGEF28 ARHGEF5 OBSCN ARHGEF2

8.85e-04701144PS50010
Domain-

ARHGEF28 ARHGEF5 OBSCN ARHGEF2

9.34e-047111441.20.900.10
DomainDH-domain

ARHGEF28 ARHGEF5 OBSCN ARHGEF2

9.34e-04711144IPR000219
DomainHGTP_anticodon

TARS2 POLG2

1.29e-0391142PF03129
DomainPH

ARHGEF28 ARHGEF5 OBSCN DOK2 RASAL3 ARHGEF2 AGAP1

1.59e-032781147SM00233
DomainIPPc

SYNJ2 INPP5J

1.61e-03101142IPR000300
DomainIPPc

SYNJ2 INPP5J

1.61e-03101142SM00128
DomainVDCCAlpha1

CACNA1I CACNA1H

1.61e-03101142IPR002077
DomainPH_DOMAIN

ARHGEF28 ARHGEF5 OBSCN DOK2 RASAL3 ARHGEF2 AGAP1

1.63e-032791147PS50003
DomainPH_domain

ARHGEF28 ARHGEF5 OBSCN DOK2 RASAL3 ARHGEF2 AGAP1

1.66e-032801147IPR001849
DomainGDS_CDC24_CS

ARHGEF5 OBSCN ARHGEF2

1.72e-03391143IPR001331
DomainSH3_2

ARHGEF5 SRMS RUSC2 MYO15B

1.90e-03861144PF07653
DomainSH3_2

ARHGEF5 SRMS RUSC2 MYO15B

1.90e-03861144IPR011511
Domain-

TARS2 POLG2

1.96e-031111423.40.50.800
DomainP-loop_NTPase

MAGI1 NWD1 ABCA4 DDX17 MYO9B IFI44 CARD10 CHST1 MYO15B STARD9 NAV2 KIF5A AGAP1

2.00e-0384811413IPR027417
DomainSH3

ARHGEF5 OBSCN SRMS RUSC2 MYO15B SRGAP3

2.11e-032161146SM00326
DomainSH3

ARHGEF5 OBSCN SRMS RUSC2 MYO15B SRGAP3

2.11e-032161146PS50002
DomainSH3_domain

ARHGEF5 OBSCN SRMS RUSC2 MYO15B SRGAP3

2.31e-032201146IPR001452
Domain-

ARHGEF28 ARHGEF5 OBSCN TNS2 DOK2 RASAL3 ARHGEF2 AGAP1

2.75e-0339111482.30.29.30
Domain6-blade_b-propeller_TolB-like

WDR6 LRP4 SORL1

2.78e-03461143IPR011042
DomainPROTEIN_KINASE_TYR

FLT4 OBSCN SRMS LTK

2.95e-03971144PS00109
DomainTyr_kinase_AS

FLT4 OBSCN SRMS LTK

2.95e-03971144IPR008266
DomainLDLRA_1

PKD1 LRP4 SORL1

3.14e-03481143PS01209
DomainAnticodon-bd

TARS2 POLG2

3.20e-03141142IPR004154
DomainPLAC

ADAMTS6 ADAMTSL4

3.20e-03141142PF08686
DomainLdl_recept_b

LRP4 SORL1

3.20e-03141142PF00058
DomainLDLRB

LRP4 SORL1

3.20e-03141142PS51120
DomainLDLRA_2

PKD1 LRP4 SORL1

3.33e-03491143PS50068
DomainLY

LRP4 SORL1

3.68e-03151142SM00135
DomainLDLR_classB_rpt

LRP4 SORL1

3.68e-03151142IPR000033
DomainPH_dom-like

ARHGEF28 ARHGEF5 OBSCN TNS2 DOK2 RASAL3 ARHGEF2 AGAP1

4.61e-034261148IPR011993
DomainC1_1

ARHGEF28 MYO9B ARHGEF2

5.10e-03571143PF00130
DomainPLAC

ADAMTS6 ADAMTSL4

5.90e-03191142PS50900
DomainPLAC

ADAMTS6 ADAMTSL4

5.90e-03191142IPR010909
PathwayPID_RHOA_REG_PATHWAY

ARHGEF28 MYO9B ARHGEF5 OBSCN ARHGEF2

8.95e-0646875M68
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

SEMA6B MYO9B OBSCN CARD10 FBXO46 CCDC142 ZNRF3 PKD1 NAV2 LRP4 CACNA1H KAZALD1 LTK BCAM SLC45A1 ARHGEF2 SIPA1L2 ATP2A3 PCNT

5.42e-0911051171935748872
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

IL16 AKAP8 DIS3L HAUS5 GAS6 LGR4 OAS3 RAB11FIP1 RASAL3 DNAJC10 ZNRF3 WDR6 LRP4 FOXP1 LTK KDM1B SIPA1L2 SORL1

3.77e-0811161171831753913
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

MAGI1 AMER1 ARHGEF28 AKAP8 DSP ARHGEF5 RAB11FIP1 RUSC2 SYNJ2 LMO7 STARD9 NAV2 ARHGEF2 SIPA1L2 VCPIP1

2.16e-078611171536931259
Pubmed

Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.

ARHGEF28 NRDC RBBP5 ARHGEF5 TARS2 RUSC2 DNAJC10 WDR6 SUPT5H ARHGEF2 COG4 SORL1

2.11e-066501171238777146
Pubmed

A human MAP kinase interactome.

MAGI1 KRT5 RIPOR2 DSP SYNPO RASAL3 SYNJ2 NAV2 KIF5A COG4

6.09e-064861171020936779
Pubmed

LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells.

AMER1 DDX17 RRP1B DSP HAUS5 MYO15B WDR6 ARHGEF2 LAS1L SIPA1L2 SORL1

1.10e-056391171123443559
Pubmed

Perm1 regulates cardiac energetics as a downstream target of the histone methyltransferase Smyd1.

SMYD1 PERM1

1.12e-052117232574189
Pubmed

A T-type calcium channel required for normal function of a mammalian mechanoreceptor.

CACNA1I CACNA1H

1.12e-052117212808460
Pubmed

Rebound burst firing in the reticular thalamus is not essential for pharmacological absence seizures in mice.

CACNA1I CACNA1H

1.12e-052117225071191
Pubmed

The RhoA regulators Myo9b and GEF-H1 are targets of cyclic nucleotide-dependent kinases in platelets.

MYO9B ARHGEF2

1.12e-052117232692911
Pubmed

Whole Exome Sequencing of Hemiplegic Migraine Patients Shows an Increased Burden of Missense Variants in CACNA1H and CACNA1I Genes.

CACNA1I CACNA1H

1.12e-052117236786913
Pubmed

High levels of circulating CD34+/VEGFR3+ lymphatic/vascular endothelial progenitor cells is correlated with lymph node metastasis in patients with epithelial ovarian cancer.

FLT4 CD34

1.12e-052117223803010
Pubmed

Comparative analysis of Six 3 and Six 6 distribution in the developing and adult mouse brain.

SIX3 SIX6

1.12e-052117215973738
Pubmed

Six3 and Six6 jointly control diverse target genes in multiple cell populations over developmental trajectories of mouse embryonic retinal progenitor cells.

SIX3 SIX6

1.12e-052117239446806
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

RRP1B HAUS5 SYNPO PLPPR4 SYNJ2 LMO7 NAV2 LRP4 CARNS1 AGAP1

1.27e-055291171014621295
Pubmed

Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.

AKAP8 RRP1B RBBP5 DNAJC10 WDR6 SUPT5H TBC1D12 ARHGEF2 LAS1L

1.89e-05440117934244565
Pubmed

Genetic predictors of fibrin D-dimer levels in healthy adults.

ABCA4 ARHGEF28 LRP4

2.01e-0516117321502573
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

KRT5 AMER1 DDX17 DSP SYNPO TASOR2 DNAJC10 LMO7 STARD9 ETHE1 NAV2 KIF5A ARHGEF2 SIPA1L2 ATP2A3 PCNT

2.73e-0514421171635575683
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

DSP ZNF584 DIS3L CRTAC1 SYNPO TDP2 LMO7 SUPT5H PKD1 LRP4 KIF5A COG4 AGAP1 PCNT VCPIP1

2.79e-0512851171535914814
Pubmed

Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.

DDX17 AKAP8 DSP RBBP5 CARD10 MYO15B LMO7 ARHGEF2 LAS1L PCNT

2.86e-055821171020467437
Pubmed

Architectural niche organization by LHX2 is linked to hair follicle stem cell function.

KRT5 CD34 PCNT

2.92e-0518117324012369
Pubmed

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.

KRT5 DSP MYO9B TDP2 LMO7 SUPT5H SIPA1L2 PCNT VCPIP1 SORL1

3.12e-055881171038580884
Pubmed

Unlike LGR4, LGR5 potentiates Wnt-β-catenin signaling without sequestering E3 ligases.

LGR4 ZNRF3

3.36e-053117233262293
Pubmed

Ethanol inhibition of a T-type Ca²+ channel through activity of protein kinase C.

CACNA1I CACNA1H

3.36e-053117223488970
Pubmed

Making a connection: direct binding between keratin intermediate filaments and desmosomal proteins.

KRT5 DSP

3.36e-05311727525601
Pubmed

T-type channels: release a brake, engage a gear.

CACNA1I CACNA1H

3.36e-053117226488564
Pubmed

Differential interactions of Na+ channel toxins with T-type Ca2+ channels.

CACNA1I CACNA1H

3.36e-053117218591418
Pubmed

Identification of the t-type calcium channel (Ca(v)3.1d) in developing mouse heart.

CACNA1I CACNA1H

3.36e-053117211230107
Pubmed

Prognostic relevance of a T-type calcium channels gene signature in solid tumours: A correlation ready for clinical validation.

CACNA1I CACNA1H

3.36e-053117228846697
Pubmed

Homeostatic plasticity and burst activity are mediated by hyperpolarization-activated cation currents and T-type calcium channels in neuronal cultures.

CACNA1I CACNA1H

3.36e-053117233547341
Pubmed

Calmodulin regulates Cav3 T-type channels at their gating brake.

CACNA1I CACNA1H

3.36e-053117228972185
Pubmed

Specific contribution of human T-type calcium channel isotypes (alpha(1G), alpha(1H) and alpha(1I)) to neuronal excitability.

CACNA1I CACNA1H

3.36e-053117211927664
Pubmed

CCDC88B interacts with RASAL3 and ARHGEF2 and regulates dendritic cell function in neuroinflammation and colitis.

RASAL3 ARHGEF2

3.36e-053117238200184
Pubmed

Interaction with both ZNRF3 and LGR4 is required for the signalling activity of R-spondin.

LGR4 ZNRF3

3.36e-053117224165923
Pubmed

RNF43/ZNRF3 negatively regulates taste tissue homeostasis and positively regulates dorsal lingual epithelial tissue homeostasis.

KRT5 ZNRF3

3.36e-053117234995498
Pubmed

Sulfotransferases of two specificities function in the reconstitution of high endothelial cell ligands for L-selectin.

CHST1 CD34

3.36e-053117210330415
Pubmed

Alpha(1H) mRNA in single skeletal muscle fibres accounts for T-type calcium current transient expression during fetal development in mice.

CACNA1I CACNA1H

3.36e-053117211897840
Pubmed

Identifying biological pathways that underlie primordial short stature using network analysis.

KRT5 DDX17 AKAP8 RRP1B DSP MYO9B HAUS5 EFNB1 LMO7 SUPT5H ARHGEF2 LAS1L PCNT

4.25e-0510241171324711643
Pubmed

Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.

MAGI1 SMYD1 GRM3 TMEM132D FOXP1 CACNA1I

6.01e-05199117623382691
Pubmed

The homeodomain transcription factor Six3 regulates hypothalamic Pomc expression and its absence from POMC neurons induces hyperphagia and mild obesity in male mice.

SIX3 SIX6

6.70e-054117239025297
Pubmed

Pharmacogenetics of antiepileptic drug efficacy in childhood absence epilepsy.

CACNA1I CACNA1H

6.70e-054117228165634
Pubmed

Gene expression profiling and qRT-PCR expression of RRP1B, PCNT, KIF21A and ADRB2 in leucocytes of Down's syndrome subjects.

RRP1B PCNT

6.70e-054117222552340
Pubmed

A novel combination of factors, termed SPIE, which promotes dopaminergic neuron differentiation from human embryonic stem cells.

PTN EFNB1

6.70e-054117219672298
Pubmed

Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1.

MAGI1 SYNPO

6.70e-054117212042308
Pubmed

Six6 (Optx2) is a novel murine Six3-related homeobox gene that demarcates the presumptive pituitary/hypothalamic axis and the ventral optic stalk.

SIX3 SIX6

6.70e-054117210473118
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

RIPOR2 RUSC2 SRGAP3 STARD9 CACNA1H SIPA1L2 PCNT VCPIP1

7.38e-05407117812693553
Pubmed

Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence.

SYNPO GALNT17 ADAMTS6 FOXP1 KDM1B PRODH

8.30e-0521111767566098
Pubmed

Epidermal development requires ninein for spindle orientation and cortical microtubule organization.

KRT5 DSP PCNT

9.12e-0526117330923192
Pubmed

Gene expression is dynamically regulated in retinal progenitor cells prior to and during overt cellular differentiation.

SIX3 SIX6 BHLHE22

1.02e-0427117324148613
Pubmed

Identification of podocalyxin-like protein 1 as a novel cell surface marker for hemangioblasts in the murine aorta-gonad-mesonephros region.

PTN CD34

1.11e-045117210591182
Pubmed

Genome-wide association study identifies two susceptibility loci for osteosarcoma.

TASOR2 ADAMTS6

1.11e-045117223727862
Pubmed

Genomic code for Sox2 binding uncovers its regulatory role in Six3 activation in the forebrain.

SIX3 SIX6

1.11e-045117223792023
Pubmed

Endothelial cells from humans and mice with polycystic kidney disease are characterized by polyploidy and chromosome segregation defects through survivin down-regulation.

PKD1 PCNT

1.11e-045117221041232
Pubmed

A novel mouse model reveals that polycystin-1 deficiency in ependyma and choroid plexus results in dysfunctional cilia and hydrocephalus.

PKD1 PCNT

1.11e-045117219774080
Pubmed

ASD-Associated De Novo Mutations in Five Actin Regulators Show Both Shared and Distinct Defects in Dendritic Spines and Inhibitory Synapses in Cultured Hippocampal Neurons.

MYO9B SRGAP3

1.11e-045117230123108
Pubmed

Evolutionary comparison reveals that diverging CTCF sites are signatures of ancestral topological associating domains borders.

SIX3 SIX6

1.11e-045117226034287
Pubmed

LGR4 and LGR5 form distinct homodimers that only LGR4 complexes with RNF43/ZNRF3 to provide high affinity binding of R-spondin ligands.

LGR4 ZNRF3

1.11e-045117237402772
Pubmed

Interaction of the apolipoprotein E receptors low density lipoprotein receptor-related protein and sorLA/LR11.

LRP4 SORL1

1.11e-045117219047013
Pubmed

Vascular Endothelial Growth Factor C for Polycystic Kidney Diseases.

FLT4 PKD1

1.11e-045117226038530
Pubmed

The LIM homeobox transcription factor Lhx2 is required to specify the retina field and synergistically cooperates with Pax6 for Six6 trans-activation.

SIX3 SIX6

1.11e-045117219146846
Pubmed

A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.

AKAP8 NRDC RRP1B TNS2 TDP2 DNAJC10 WDR6 SUPT5H KIF5A SIPA1L2 VCPIP1 SORL1

1.13e-049741171228675297
Pubmed

Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets.

PERM1 CARD10 SYBU STARD9 KIF5A LTK

1.43e-04233117637704626
Pubmed

The human cytoplasmic dynein interactome reveals novel activators of motility.

KRT5 AMER1 DSP DIS3L HAUS5 KATNB1 SYNJ2 ARHGEF2 SIPA1L2 PCNT VCPIP1

1.48e-048531171128718761
Pubmed

Mouse Dach2 mutants do not exhibit gross defects in eye development or brain function.

SIX3 SIX6

1.67e-046117216470613
Pubmed

Six3-mediated auto repression and eye development requires its interaction with members of the Groucho-related family of co-repressors.

SIX3 SIX6

1.67e-046117212050133
Pubmed

Abnormal adherence junctions in the heart and reduced angiogenesis in transgenic mice overexpressing mutant type XIII collagen.

DSP CD34

1.67e-046117211566879
Pubmed

Alterations in the thymocyte phenotype of EphB-deficient mice largely affect the double negative cell compartment.

KRT5 EFNB1

1.67e-046117218397270
Pubmed

Characterization of the Six1 homeobox gene in normal mammary gland morphogenesis.

SIX3 SIX6

1.67e-046117220074369
Pubmed

The expression profile and clinic significance of the SIX family in non-small cell lung cancer.

SIX3 SIX6

1.67e-046117227821176
Pubmed

Reconstitution of R-spondin:LGR4:ZNRF3 adult stem cell growth factor signaling complexes with recombinant proteins produced in Escherichia coli.

LGR4 ZNRF3

1.67e-046117224050775
Pubmed

Dynamic expression of Six family genes in the dental mesenchyme and the epithelial ameloblast stem/progenitor cells during murine tooth development.

SIX3 SIX6

1.67e-046117219900183
Pubmed

Structural and molecular basis of ZNRF3/RNF43 transmembrane ubiquitin ligase inhibition by the Wnt agonist R-spondin.

LGR4 ZNRF3

1.67e-046117224225776
Pubmed

RNAi screens in mice identify physiological regulators of oncogenic growth.

KRT5 CD34

1.67e-046117223945586
Pubmed

Structural basis for the selective activation of Rho GTPases by Dbl exchange factors.

ARHGEF5 ARHGEF2

1.67e-046117212006984
Pubmed

Engineering high-potency R-spondin adult stem cell growth factors.

LGR4 ZNRF3

1.67e-046117225504990
Pubmed

Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.

STARD9 NAV2 ARHGAP28 SIPA1L2 CARNS1

1.74e-04153117510718198
Pubmed

High-throughput analyses of hnRNP H1 dissects its multi-functional aspect.

DDX17 AKAP8 OBSCN TNS2 CARD10 SYNPO FBXO46 WDR6 ETHE1 KAZALD1 LAS1L CARNS1

1.74e-0410211171226760575
Pubmed

Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.

RIPOR2 DSP MYO9B OBSCN TARS2 DMXL1 TASOR2 PTN PKD1 EMC10 ARHGEF2 SIPA1L2 PRODH

2.32e-0412151171315146197
Pubmed

An essential role for Prox1 in the induction of the lymphatic endothelial cell phenotype.

FLT4 CD34

2.33e-047117211927535
Pubmed

Regulation of a remote Shh forebrain enhancer by the Six3 homeoprotein.

SIX3 SIX6

2.33e-047117218836447
Pubmed

Angiopoietin-1 promotes LYVE-1-positive lymphatic vessel formation.

FLT4 CD34

2.33e-047117215705793
Pubmed

RSPO2 and RANKL signal through LGR4 to regulate osteoclastic premetastatic niche formation and bone metastasis.

LGR4 LRP4

2.33e-047117234847079
Pubmed

USP42 protects ZNRF3/RNF43 from R-spondin-dependent clearance and inhibits Wnt signalling.

LGR4 ZNRF3

2.33e-047117233786993
Pubmed

Differential activities and mechanisms of the four R-spondins in potentiating Wnt/β-catenin signaling.

LGR4 ZNRF3

2.33e-047117229752411
Pubmed

Signal peptide prediction based on analysis of experimentally verified cleavage sites.

SEMA6B FLT4 EFNB1 CLEC14A CD163L1 KAZALD1

2.80e-04264117615340161
Pubmed

Six3 and Six6 activity is modulated by members of the groucho family.

SIX3 SIX6

3.10e-048117212441302
Pubmed

Evolutionary insights into T-type Ca2+ channel structure, function, and ion selectivity from the Trichoplax adhaerens homologue.

CACNA1I CACNA1H

3.10e-048117228330839
Pubmed

Neuroepithelial progenitors generate and propagate non-neuronal action potentials across the spinal cord.

CACNA1I CACNA1H

3.10e-048117234478646
Pubmed

Association analysis of the glutamic acid decarboxylase 2 and the glutamine synthetase genes (GAD2, GLUL) with schizophrenia.

GRIK5 GRM3

3.10e-048117219125103
Pubmed

Intracellular calcium plays an essential role in cardiac development.

CACNA1I CACNA1H

3.10e-048117212761855
Pubmed

A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

DDX17 AKAP8 RRP1B RAB11FIP1 LMO7 NAV2 ARHGEF2 LAS1L

3.12e-04503117816964243
Pubmed

Gbx2 is essential for maintaining thalamic neuron identity and repressing habenular characters in the developing thalamus.

CHST1 SIX3 BHLHE22

3.35e-0440117326297811
Pubmed

mTORC1 activity regulates post-translational modifications of glycine decarboxylase to modulate glycine metabolism and tumorigenesis.

MAGI1 DDX17 AKAP8 RRP1B DNAJC10 LMO7

3.41e-04274117634244482
Pubmed

New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing.

DDX17 RRP1B SYNPO ADAMTS6 STARD9 TBC1D12 CACNA1H ATP2A3

3.55e-04513117825798074
Pubmed

Deubiquitinase OTUD3 regulates metabolism homeostasis in response to nutritional stresses.

SIX3 BHLHE22

3.98e-049117235675826
Pubmed

International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels.

CACNA1I CACNA1H

3.98e-049117216382099
Pubmed

The homeodomain protein Vax2 patterns the dorsoventral and nasotemporal axes of the eye.

SIX6 EFNB1

3.98e-049117211830578
Pubmed

Hypothalamic dysregulation and infertility in mice lacking the homeodomain protein Six6.

SIX3 SIX6

3.98e-049117221228153
Pubmed

Pleiotropic effects in Eya3 knockout mice.

SIX3 SIX6

3.98e-049117219102749
Pubmed

Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer.

MAGI1 ARHGEF5 SYNJ2 LMO7

4.01e-04102117415778465
InteractionYWHAG interactions

MAGI1 RIPOR2 AMER1 DDX17 ARHGEF28 AKAP8 DSP ARHGEF5 LGR4 TNS2 SYNPO RAB11FIP1 RUSC2 SYNJ2 LMO7 STARD9 NAV2 KIF5A ARHGEF2 SIPA1L2 CCS AGAP1

1.92e-06124811522int:YWHAG
InteractionNTN5 interactions

AMER1 LGR4 LRP4 SORL1

9.79e-06241154int:NTN5
InteractionYWHAH interactions

MAGI1 AMER1 ARHGEF28 AKAP8 DSP ARHGEF5 TNS2 RAB11FIP1 RUSC2 SYNJ2 LMO7 STARD9 NAV2 KIF5A ARHGEF2 SIPA1L2 AGAP1 PCNT VCPIP1

1.46e-05110211519int:YWHAH
Cytoband8q13

BHLHE22 VCPIP1

4.18e-041211728q13
Cytoband12q13.13

KRT5 TNS2 KIF5A

6.86e-0467117312q13.13
Cytoband22q13.1

DDX17 CARD10 CACNA1I

1.37e-0385117322q13.1
Cytoband3p14.1

MAGI1 FOXP1

1.71e-032411723p14.1
CytobandXq12

EFNB1 LAS1L

2.01e-03261172Xq12
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

ARHGEF5 OBSCN ARHGEF35 ARHGEF2

2.87e-0466874722
GeneFamilySINE class homeoboxes

SIX3 SIX6

3.39e-046872525
CoexpressionGAUSSMANN_MLL_AF4_FUSION_TARGETS_F_UP

GAS6 IFI44 CARD10 SYNPO LMO7 BHLHE22 ARHGAP28 ADAMTSL4

1.80e-061841178M8544
CoexpressionGAUSSMANN_MLL_AF4_FUSION_TARGETS_F_UP

GAS6 IFI44 CARD10 SYNPO LMO7 BHLHE22 ARHGAP28 ADAMTSL4

2.11e-061881178MM983
CoexpressionHUTTMANN_B_CLL_POOR_SURVIVAL_UP

IL16 MYO9B IFI44 SIX6 MYO15B CD6 ADAMTS6 LTK ATP2A3

5.39e-062841179M19993
CoexpressionLAKE_ADULT_KIDNEY_C20_COLLECTING_DUCT_INTERCALATED_CELLS_TYPE_A_CORTEX

MAGI1 ARHGEF28 NRDC DSP LGR4 GALNT17 FOXP1

5.59e-061521177M39239
ToppCell10x3'2.3-week_17-19-Endothelial-stroma-proliferating_EC|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

FLT4 ARHGEF28 TNS2 CARD10 SYBU CLEC14A CD34 ARHGAP28 BCAM

1.63e-091861179a844d4f79e0ad5d6c60a4488ffd8f4f21b7eed04
ToppCell367C-Endothelial_cells-Endothelial-F_(Lymphatics)|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

FLT4 ABCA4 LAYN DSP CRTAC1 RAB11FIP1 SRGAP3 CD163L1 CYP4X1

2.16e-0919211795e709c0714e8eba27e03a6def0544256bedb3ced
ToppCell367C-Endothelial_cells-Endothelial-F_(Lymphatics)-|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

FLT4 ABCA4 LAYN DSP CRTAC1 RAB11FIP1 SRGAP3 CD163L1 CYP4X1

2.16e-0919211795f4f44f15d3a2846981e68296643a4634930a211
ToppCell10x3'2.3-week_14-16-Endothelial-stroma-tip_EC|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

MAGI1 FLT4 ARHGEF28 CARD10 SYNPO CLEC14A CD34 ARHGAP28 BCAM

2.96e-0919911791c69395c9305b6ecb0a826d46c8e8ec95795ad6d
ToppCellnormal_Lung-Endothelial_cells-Tumor_ECs|normal_Lung / Location, Cell class and cell subclass

MAGI1 FLT4 CARD10 SYNPO CHST1 CLEC14A CD34 BCAM

3.13e-0818411787ee98acda030366ac6cf3890a6d93fd0426712ed
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Endothelial-endothelial_cell|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SEMA6B MAGI1 GAS6 CARD10 SYNPO RUSC2 CLEC14A CD34

3.55e-0818711783548a9914c2b2f5d805798ce22ab26eab6d03897
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Endothelial-endothelial_cell|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SEMA6B MAGI1 GAS6 CARD10 SYNPO RUSC2 CLEC14A CD34

3.55e-081871178f4de4b7af1fdfbd628b1f509c060c1079d2e5437
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Endothelial|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SEMA6B MAGI1 GAS6 CARD10 SYNPO RUSC2 CLEC14A CD34

3.55e-08187117881754e965848b718be20ee97ce072ce426938a69
ToppCell10x5'v1-week_12-13-Endothelial-stroma-tip_EC|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

MAGI1 FLT4 ARHGEF28 TNS2 CARD10 SYNPO CLEC14A ARHGAP28

4.18e-081911178cf1a67b7c0d5c0dc5d4d59faf9d9b1a3a1fb00e0
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SEMA6B IFI44 SYBU ADAMTS6 SYNJ2 CLEC14A CD34 ATP2A3

4.36e-081921178bacbaef1f230051335f4433e55db07a161b96b4c
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SEMA6B FLT4 GAS6 SYNPO CLEC14A CD163L1 CD34 ARHGAP28

4.53e-0819311781f978e102a029a6beb10913052cd0a20c7253e8e
ToppCellDiffer-Basal|World / shred by cell class for mouse tongue

LGR4 PTN ZNRF3 LMO7 NAV2 LRP4 FOXP1 PRODH

4.72e-081941178851eff82c9f3d44c86e3e127a804bbd1fced6a7c
ToppCell10x5'v1-week_12-13-Endothelial-stroma|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

MAGI1 FLT4 ARHGEF28 TNS2 CARD10 SYNPO CLEC14A ARHGAP28

5.52e-081981178122215d9288533ad03562cf777e846504863df9a
ToppCell10x5'v1-week_12-13-Endothelial|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

MAGI1 FLT4 ARHGEF28 TNS2 CARD10 SYNPO CLEC14A ARHGAP28

5.52e-081981178307dd09e6bc820a148f3000f18dae7aedba4be0b
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SEMA6B FLT4 GAS6 SYNPO SELENON EFNB1 CLEC14A CD34

5.74e-081991178da5a88749d859d535daa030d0974485906cc0ba7
ToppCell10x5'v1-week_14-16-Endothelial-stroma-tip_EC|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

MAGI1 FLT4 ARHGEF28 CARD10 SYNPO CLEC14A CD34 BCAM

5.97e-08200117877ac1aa73c16a4f595ff01c6b4e171e0b8fed1e6
ToppCellLung_Parenchyma-Control-Epithelial-Epithelial-AT1-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

DSP GAS6 SYNPO RAB11FIP1 LMO7 NAV2 BCAM GOLGA8A

5.97e-082001178c6f211bbadd0c9be776c58807249e06764df47dc
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SEMA6B FLT4 TNS2 SYNPO EFNB1 ADAMTS6 CLEC14A CD34

5.97e-0820011782e47888e041ec3d265425d1df97b6665c6da889c
ToppCellLung_Parenchyma-Control-Epithelial-Epithelial-AT1|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

DSP GAS6 SYNPO RAB11FIP1 LMO7 NAV2 BCAM GOLGA8A

5.97e-0820011785f7e8d8b05c90a10313775f9f126eb4ab0fe4f67
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SEMA6B FLT4 TNS2 SYNPO EFNB1 ADAMTS6 CLEC14A CD34

5.97e-08200117850fa0f8a3e490d5941b34e66a10158eba6c909d4
ToppCellParenchyma_Control_(B.)-Epithelial-TX-AT1|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type

DSP GAS6 SYNPO RAB11FIP1 LMO7 NAV2 BCAM GOLGA8A

5.97e-082001178e3a80626941363bfc9d97ef906d38c97080aecb1
ToppCellEntopeduncular-Endothelial-ENDOTHELIAL_STALK|Entopeduncular / BrainAtlas - Mouse McCarroll V32

FLT4 LAYN IFI44 SRMS RAB11FIP1 CLEC14A CD34

2.25e-07160117704714d0b9bad4c11fa193ed168e2d84a4df39e2e
ToppCellP03-Epithelial-airway_epithelial_cell-ciliated_cell_of_airway|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

MAGI1 AMHR2 ARHGEF28 DSP RAB11FIP1 LMO7 BCAM

4.29e-071761177f3a54038cde58326f1caed96ecca33c141bcc8b3
ToppCell367C-Endothelial_cells-Endothelial-F_(Lymphatics)-|367C / Donor, Lineage, Cell class and subclass (all cells)

FLT4 ABCA4 LAYN DSP CRTAC1 CARD10 SRGAP3

5.19e-071811177b244ecaa442bbef51289d8ec574ef08fa9e96318
ToppCell367C-Endothelial_cells-Endothelial-F_(Lymphatics)|367C / Donor, Lineage, Cell class and subclass (all cells)

FLT4 ABCA4 LAYN DSP CRTAC1 CARD10 SRGAP3

5.19e-071811177dd79de8098edb385a0f85d0e9621503cdf76ec43
ToppCellASK454-Epithelial|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq

GAS6 EFHB LMO7 NAV2 CYP4X1 CARNS1 GOLGA8A

5.38e-071821177ab15316cff989b61ff397a866d7ca8b49c13e981
ToppCellfacs-SCAT-Fat-3m-Lymphocytic-B_cell|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RIPOR2 DMXL1 RASAL3 FOXP1 CACNA1I ATP2A3 SORL1

6.23e-071861177d5d990d8b6ccd8ca8fe7d0d7dedbe2359ae7b582
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

MAGI1 ARHGEF28 LGR4 GALNT17 LMO7 FOXP1 SIPA1L2

6.23e-071861177a6ef5d5944af5689b5f27bef89cd05645eedbe50
ToppCellTuft-tuft-2|World / Class top

IL16 PCDH20 ETHE1 NAV2 ARHGEF2 ATP2A3 INPP5J

6.46e-0718711774ec6eee866619dfe13c84f5d2e812bb380d37139
ToppCellCOVID-19-Epithelial_cells-Airway_basal|COVID-19 / group, cell type (main and fine annotations)

KRT5 DSP LGR4 SRGAP3 CYP4X1 LRP4 BCAM

6.46e-0718711778407a82e98f56a94ea26562bcb6bbe00a8f41661
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

MAGI1 RAB11FIP1 LMO7 TMEM132D NAV2 CYP4X1 GOLGA8A

6.69e-071881177eea652bab161f19148a883e7e3fe2523b36b3cea
ToppCellkidney_cells-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SEMA6B TNS2 SYNPO ADAMTS6 CLEC14A CD34 ATP2A3

6.69e-071881177a37edd8f9e4a4e336b5acbb0407d3d275975cee8
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

MAGI1 ARHGEF28 LGR4 GALNT17 LMO7 FOXP1 SIPA1L2

6.69e-071881177e751cff2ac8fbc1487766c1871fcc5d1005286b0
ToppCellChildren_(3_yrs)-Mesenchymal-pericyte_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

OBSCN LGR4 TNS2 PTN STARD9 CACNA1H AGAP1

6.69e-071881177ee151792c7ac9afe820f1a281c6dab383799f358
ToppCelldroplet-Lung-LUNG-1m-Mesenchymal-bronchial_smooth_muscle_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARHGEF5 LGR4 SYBU GALNT17 PLPPR4 GOLGA8A INPP5J

6.94e-0718911774dc32b463546bbe7250dddd281b92ad17ec22da1
ToppCelldroplet-Lung-LUNG-1m-Mesenchymal-Airway_Smooth_Muscle|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARHGEF5 LGR4 SYBU GALNT17 PLPPR4 GOLGA8A INPP5J

6.94e-0718911770d06bf0d7191d13a1c4f30a7881e7ea1093bfd6f
ToppCellFetal_29-31_weeks-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

FLT4 EFNB1 CLEC14A CD34 LTK BCAM SIPA1L2

7.44e-0719111771de0bdfd13bd930691564c2673f2e66393bc0255
ToppCellwk_20-22-Endothelial-Lymph_endothelial|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

MAGI1 FLT4 ABCA4 LAYN DSP CRTAC1 CARD10

7.44e-071911177631f95fd80dd3678b5b2ef201abf7fe646049af6
ToppCellBasal_cells-IPF_02|World / lung cells shred on cell class, cell subclass, sample id

KRT5 DSP LGR4 PTN SRGAP3 LRP4 GOLGA8A

7.44e-071911177a98915bad9a4a61dd4cbca798914849b805f4a19
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

MAGI1 SYBU RAB11FIP1 LMO7 NAV2 CYP4X1 ARHGEF2

7.71e-07192117729f49f00770c991b5f27e4cb701dd2d2d6cb7178
ToppCellIPF-Epithelial-Basal|World / Disease state, Lineage and Cell class

KRT5 DSP LGR4 LMO7 SRGAP3 CYP4X1 BCAM

7.71e-0719211779b91e0b162e6f3ce86dd15cc33c2e745d069581f
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SEMA6B TNS2 SYNPO ADAMTS6 SYNJ2 CLEC14A CD34

7.98e-071931177cc355b2ed6510619cad969ae074126d7c8db784d
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-DC-DC3-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

KRT5 RIPOR2 DSP GAS6 RAB11FIP1 LTK ATP2A3

7.98e-0719311775a4accf3af236ff285942163c45277a80263f421
ToppCell(6)_Endothelial_cells-(6)_Endothelial-F_(Lymphatics)|(6)_Endothelial_cells / Lung cell shreds - cell class (v4) and cell subclass (v4)

FLT4 LAYN DSP CRTAC1 RAB11FIP1 SRGAP3 CD163L1

8.26e-0719411779441202d6fa2ffbef9277d48ae9bc98876c26ec5
ToppCellParenchymal-NucSeq-Epithelial-Epi_airway_basal-Basal|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

KRT5 LAYN OBSCN LGR4 SIX6 SRGAP3 GOLGA8A

8.55e-0719511776c9c58322c1df891bb4bab56dacb542c8777bb7d
ToppCellTCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-4|TCGA-Prostate / Sample_Type by Project: Shred V9

LAYN GAS6 SYNPO GRIK5 RUSC2 NAV2 ARHGEF2

8.55e-0719511775562665dd3beb70e2358aa32611a337bef5731c1
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-DC-DC3|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

KRT5 RIPOR2 DSP GAS6 RAB11FIP1 LTK ATP2A3

8.55e-071951177de60fa0c69c835f0b1d6d2dba1a1acd73246b001
ToppCellwk_15-18-Endothelial-Lymph_endothelial|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

FLT4 ABCA4 LAYN DSP CRTAC1 CARD10 SELENON

8.85e-071961177ff627244d7f5fd6a2ec009dae32d3509f0e2d95e
ToppCellPND03-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1-AT1_mature|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MAGI1 ARHGEF28 DSP RAB11FIP1 LMO7 NAV2 BCAM

8.85e-0719611779790340c25f446ec655f5a0b64ec3bb44ed2e1bd
ToppCellPND03-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MAGI1 ARHGEF28 DSP RAB11FIP1 LMO7 NAV2 BCAM

8.85e-071961177b9ceceeacbcf81976ce92adf044f0d0aa132632b
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SEMA6B FLT4 GAS6 SYNPO ADAMTS6 CLEC14A CD34

8.85e-071961177e224338490691d92c1f70b57112fabdcc92b06a9
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SEMA6B FLT4 GAS6 SYNPO ADAMTS6 CLEC14A CD34

9.16e-071971177c10dd1aaec01fb662eac83dfde90e3e426665d65
ToppCellBasal_cells|World / lung cells shred on cell class, cell subclass, sample id

KRT5 DSP LGR4 SRGAP3 CYP4X1 LRP4 GOLGA8A

9.16e-07197117724360b660000bdfb999d58fbf4e29585a97e1785
ToppCellnormal_Lung-Endothelial_cells-Lymphatic_ECs|Endothelial_cells / Location, Cell class and cell subclass

FLT4 LAYN DSP CRTAC1 RAB11FIP1 SRGAP3 CYP4X1

9.16e-071971177c838d0f64e3b43a616a9e381b8139bfe9aa32da7
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SEMA6B FLT4 GAS6 SYNPO ADAMTS6 CLEC14A CD34

9.16e-0719711772844dbcd0a673ed81c99920aa45858651a00736d
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SEMA6B IFI44 SYNPO ADAMTS6 SYNJ2 CLEC14A CD34

9.47e-071981177b027a141ab531d0f5d6a26811a53427e7b0771dd
ToppCellEpithelial_cells-Basal_cells|Epithelial_cells / lung cells shred on cell class, cell subclass, sample id

KRT5 DSP LGR4 EFNB1 SRGAP3 LRP4 GOLGA8A

9.47e-0719811774235005c49fc2b29ad3a0ee6b608f0109d04f775
ToppCell10x3'2.3-week_17-19-Endothelial|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

MAGI1 FLT4 ARHGEF28 CARD10 CLEC14A ARHGAP28 BCAM

9.47e-0719811772630a7a6e56febe5c0b0bde70dd7292fa1650c47
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SEMA6B FLT4 IFI44 SYNPO ADAMTS6 CLEC14A CD34

9.47e-071981177953630dbe3154b1b102b87de0feca2cbf124eabe
ToppCell10x3'2.3-week_17-19-Endothelial-stroma|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

MAGI1 FLT4 ARHGEF28 CARD10 CLEC14A ARHGAP28 BCAM

9.47e-0719811771e83bec16dcd60460422625f89952ff506d6be51
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SEMA6B FLT4 IFI44 SYNPO ADAMTS6 CLEC14A CD34

9.47e-0719811778e45551224fbb30c0658ad47dd98335ecf165437
ToppCell10x3'2.3-week_14-16-Endothelial|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

MAGI1 FLT4 ARHGEF28 CARD10 CLEC14A ARHGAP28 BCAM

9.80e-07199117741f046646fff65b7e51b63d3204f76ef32054781
ToppCellControl_saline|World / Treatment groups by lineage, cell group, cell type

FLT4 DSP ZNRF3 CD34 BCAM SIPA1L2 ATP2A3

9.80e-07199117711c9c1779caceb725ecccf3f23b7d4e6dbd1af64
ToppCell10x_3'_v2v3-Non-neoplastic-Vascular-Mural_cell-Scavenging_endothelial|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

FLT4 ARHGEF28 LINC02875 CHST1 ARHGEF35 CLEC14A CD34

9.80e-071991177d95d78b2ebc9a20532466e4d4be579b4faf6776f
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SEMA6B IFI44 TNS2 SYNPO ADAMTS6 CLEC14A CD34

9.80e-071991177f35e9c05d0a0339ff691b38564da7aad8e9218aa
ToppCell10x_3'_v2v3-Non-neoplastic-Vascular-Mural_cell-Scavenging_endothelial-F|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

FLT4 ARHGEF28 LINC02875 CHST1 ARHGEF35 CLEC14A CD34

9.80e-071991177cdcfca94baba66e213cc3ffb0cfb4c75d6ab44ec
ToppCell10x3'2.3-week_14-16-Endothelial-stroma|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

MAGI1 FLT4 ARHGEF28 CARD10 CLEC14A ARHGAP28 BCAM

9.80e-071991177ef7f7f7c861827574b120f48cf4052c563929081
ToppCelldistal-3-Endothelial-Capillary_Aerocyte|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

FLT4 CHST1 EFNB1 CLEC14A CD34 LTK BCAM

1.01e-062001177e12598a097dd9c4cbf9bb85bfa3057722ef73ad5
ToppCellBronchial-NucSeq-Epithelial-Epi_submucosal-gland-SMG_Serous|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ARHGEF28 DSP LGR4 SYNJ2 SRGAP3 CYP4X1 ATP2A3

1.01e-062001177030efc36bbb848da31b0db3f74d46aac9c79cc9b
ToppCelldistal-Endothelial-Capillary_Aerocyte-1|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

FLT4 LAYN CHST1 EFNB1 CLEC14A CD34 BCAM

1.01e-0620011770656906d16b0df19c0511965b5d18e9eab3cb168
ToppCellParenchyma_COVID-19-Epithelial-TX-Basal_1|Parenchyma_COVID-19 / Sample group, Lineage and Cell type

KRT5 DSP ARHGEF35 LMO7 SRGAP3 CYP4X1 BCAM

1.01e-062001177592c7c3ded409a9957cbcdc62fcc213fa8eae598
ToppCell5'-Adult-SmallIntestine-Endothelial-blood_vessel_EC|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SEMA6B GAS6 TNS2 SYNPO CLEC14A CD34 BCAM

1.01e-062001177cd3c638961144a2fc91c437a173cc37c7452fa74
ToppCellBronchial-NucSeq-Epithelial-Epi_airway_basal|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

KRT5 NWD1 DSP OBSCN LGR4 PTN SRGAP3

1.01e-0620011778827653738a931e4a4545e0c7d75be12bed40740
ToppCell5'-Adult-SmallIntestine-Endothelial|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SEMA6B FLT4 TNS2 SYNPO CLEC14A CD34 BCAM

1.01e-0620011772554b77edfe3d378296b0b25625caacbfb1c0e76
ToppCellLung_Parenchyma-Severe-Epithelial-Epithelial-Basal_1-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

KRT5 DSP ARHGEF35 LMO7 SRGAP3 CYP4X1 BCAM

1.01e-0620011778cfbde43c5e66269ad128aa5398b1517667d7d36
ToppCelldistal-1-Endothelial-Capillary_Aerocyte|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

FLT4 LAYN CHST1 EFNB1 CLEC14A CD34 BCAM

1.01e-06200117759bacd738433cec6d05624a25fdfc087fb3ca3b5
ToppCellBiopsy_Other_PF-Epithelial-Basal|Biopsy_Other_PF / Sample group, Lineage and Cell type

KRT5 DSP LGR4 LMO7 SRGAP3 CYP4X1 BCAM

1.01e-0620011777098ae4b0ea8ba607519eaed8577c577530fc2a1
ToppCellLung_Parenchyma-Severe-Epithelial-Epithelial-Basal_1|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

KRT5 DSP ARHGEF35 LMO7 SRGAP3 CYP4X1 BCAM

1.01e-06200117761811380d9252f12f27b7ad4752380b52692677f
ToppCellPosterior_cortex-Endothelial-ENDOTHELIAL_STALK-Flt1_1|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

FLT4 LAYN IFI44 SRMS RAB11FIP1 CLEC14A

1.30e-061311176d46bb28612b9690b2e3550b8adbd10781788c00d
ToppCellSubstantia_nigra-Endothelial-ENDOTHELIAL_STALK|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

FLT4 LAYN IFI44 SRMS CLEC14A CD34

1.30e-061311176308ddb7fe113eac5dbeb9cb0b688d9e09275ce5e
ToppCellStriatum-Endothelial-ENDOTHELIAL_STALK-Flt1_1|Striatum / BrainAtlas - Mouse McCarroll V32

FLT4 DSP IFI44 SRMS RAB11FIP1 CLEC14A

1.69e-061371176306b11b3b9e5fd562d845fb5eaa4ac982864efce
ToppCellStriatum-Endothelial-ENDOTHELIAL_STALK|Striatum / BrainAtlas - Mouse McCarroll V32

FLT4 DSP IFI44 SRMS RAB11FIP1 CLEC14A

1.69e-061371176d37f425b13bc046baa1f8619b98a16b936f88ff6
ToppCellPosterior_cortex-Endothelial-ENDOTHELIAL_STALK|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

FLT4 LAYN IFI44 SRMS RAB11FIP1 CLEC14A

2.17e-06143117635d3652680c4dddd293301595d813161c66e5673
ToppCellGlobus_pallidus-Endothelial-ENDOTHELIAL_STALK-Flt1_1|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

FLT4 IFI44 SRMS RAB11FIP1 CLEC14A CD34

2.26e-0614411761c118b22c2ff3a526a5207d6c9d772636ee065fd
ToppCellCerebellum-Endothelial-ENDOTHELIAL_STALK-Flt1_1|Cerebellum / BrainAtlas - Mouse McCarroll V32

ARHGEF5 IFI44 SRMS CARD10 CLEC14A CD34

2.35e-06145117637580218f6a6f65a1d827cbcf59465f8827f9a55
ToppCellGlobus_pallidus-Endothelial-ENDOTHELIAL_STALK|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

FLT4 IFI44 SRMS RAB11FIP1 CLEC14A CD34

2.76e-061491176d9c47f523c75ddcd6131e45d2ffc24b970932cae
ToppCellPND01-03-samps-Epithelial-Alveolar_epithelial-AT1_-_meso|PND01-03-samps / Age Group, Lineage, Cell class and subclass

MAGI1 AMHR2 RAB11FIP1 RUSC2 LMO7 BCAM

2.86e-0615011766a13e4c4b9c9e54a5016573a37132465ec1c8f99
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-L5_IT-L5_IT_VISp_Batf3|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

GRM3 PTN GALNT17 CD34 BHLHE22 FOXP1

3.73e-061571176921805932f7974d37aed547861d555b07f30aba6
ToppCell3'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.1.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

KRT5 LAYN DSP SYBU PTN SRGAP3

4.01e-06159117622427ad4ad2e797e4664e7a7b0514094f22a18b2
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

MAGI1 LMO7 TMEM132D GOLGA8A PRODH AGAP1

4.01e-0615911768680b054622f573a82b1625fb93c2d5db81d1034
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MAGI1 ARHGEF28 GALNT17 LMO7 FOXP1 INPP5J

4.79e-061641176d847d509bb1791638032ade6755d8164586b5bd5
ToppCellCerebellum-Endothelial-ENDOTHELIAL_STALK|Cerebellum / BrainAtlas - Mouse McCarroll V32

FLT4 ARHGEF5 IFI44 SRMS CLEC14A CD34

4.96e-0616511767d319a112b9062efee428bef6f4534d2ce782e04
ToppCell367C-Myeloid-Macrophage-FABP4+_Macrophage_3|Macrophage / Donor, Lineage, Cell class and subclass (all cells)

LAYN CARD10 SYBU EFHB CD34 PRODH

5.32e-0616711765c82d801e3b7d7c6c967a73b94b2ee2a8da1fd6e
ToppCellHippocampus-Neuronal-Excitatory-eN1(Slc17a7)|Hippocampus / BrainAtlas - Mouse McCarroll V32

CHST1 GALNT17 PLPPR4 LMO7 CACNA1H SORL1

5.50e-0616811766db453cbbbaf4144a86fadcfa5805d33396713b5
ToppCellControl|World / group, cell type (main and fine annotations)

MAGI1 ARHGEF28 RAB11FIP1 LMO7 NAV2 AGAP1

5.50e-061681176a3511faf2cd2c2b9c8363c8b99da3f3609c43ed6
ToppCellfacs-Limb_Muscle-forelimb_and_hindlimb-18m-Lymphocytic-T_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RIPOR2 RAB11FIP1 CD6 RASAL3 WDR6 SORL1

5.50e-061681176182f08106ac65ea501e2fb9139d3b44b7c4662c9
ToppCell368C-Endothelial_cells-Endothelial-F_(Lymphatics)|368C / Donor, Lineage, Cell class and subclass (all cells)

FLT4 ABCA4 LAYN DSP CRTAC1 SRGAP3

5.50e-061681176a74c8a9e3299183fba31ce3053ef325b5dbcd104
ToppCell368C-Endothelial_cells-Endothelial-F_(Lymphatics)-|368C / Donor, Lineage, Cell class and subclass (all cells)

FLT4 ABCA4 LAYN DSP CRTAC1 SRGAP3

5.50e-061681176dae37b316ce80dfe4236c4ed7f0d4e7c340fa7b6
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-L5_IT|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

GRM3 PTN GALNT17 CD34 BHLHE22 FOXP1

5.89e-06170117667415b098e8ba815b501e557192a9f2b10ee995a
ToppCelldroplet-Kidney-KIDNEY-1m-Myeloid-nan|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DIS3L SRMS OAS3 TPBGL SELENON RASAL3

6.09e-061711176d9ad6a3bce3556abd24af1630bf4a99594437c3a
ComputationalNeighborhood of NOS2A

MAGI1 IL16 MYO9B GRIK5 CHST1 SIX3 SIX6 CD6 PLPPR4 SYNJ2

3.66e-052887710MORF_NOS2A
ComputationalNeighborhood of MYC

MYO9B HAUS5 GRIK5 SIX3 CD6

2.62e-0480775MORF_MYC
ComputationalNeighborhood of FLT1

MYO9B HAUS5 GRIK5 SIX3 CD6 LTK

2.77e-04126776MORF_FLT1
ComputationalNeighborhood of LTK

MYO9B HAUS5 CARD10 GRIK5 SIX3 LTK

6.30e-04147776MORF_LTK
ComputationalNeighborhood of RAGE

MYO9B HAUS5 CARD10 GRIK5 SIX3 LTK

6.53e-04148776MORF_RAGE
DrugHyoscyamine (L) [101-31-5]; Down 200; 13.8uM; MCF7; HT_HG-U133A

MAGI1 DDX17 KATNB1 TNS2 GRIK5 CD34 CACNA1H ARHGEF2

6.88e-0619211782271_DN
DrugDihydroergotoxine mesylate [8067-24-1]; Up 200; 6.4uM; MCF7; HT_HG-U133A

ARHGEF28 KATNB1 SYBU SYNJ2 CD34 CACNA1I CACNA1H KAZALD1

8.00e-0619611782793_UP
DrugNicardipine hydrochloride [54527-84-3]; Up 200; 7.8uM; MCF7; HT_HG-U133A

RIPOR2 DDX17 OAS3 CD6 CACNA1I BCAM ATP2A3 ADAMTSL4

8.00e-0619611785397_UP
DrugDizocilpine maleate [77086-22-7]; Down 200; 11.8uM; MCF7; HT_HG-U133A

MAGI1 TNS2 PTN SYNJ2 CACNA1I CACNA1H ATP2A3 PRODH

8.00e-0619611782232_DN
DrugEthynodiol diacetate [297-76-7]; Up 200; 10.4uM; MCF7; HT_HG-U133A

KATNB1 SYBU DOK2 CD6 NAV2 ATP2A3 INPP5J

5.97e-0519111776479_UP
DrugLevopropoxyphene napsylate [5714-90-9]; Up 200; 7.4uM; MCF7; HT_HG-U133A

OAS3 SYBU GRM3 CD6 CD34 CACNA1I ATP2A3

6.80e-0519511773543_UP
DrugDL-PPMP; Down 200; 2uM; MCF7; HT_HG-U133A_EA

DDX17 RRP1B HAUS5 FBXO46 SUPT5H BCAM ATP2A3

6.80e-0519511771121_DN
DrugFusidic acid sodium salt [751-94-0]; Down 200; 7.4uM; PC3; HT_HG-U133A

FLT4 DDX17 HAUS5 LMO7 CACNA1I KAZALD1 ARHGEF2

6.80e-0519511776754_DN
Drugbenz(a)anthracene

RIPOR2 DDX17 AKAP8 HAUS5 GAS6 IFI44 CHST1 RAB11FIP1 EFHB PTN KRBA1 EFNB1 ETHE1 CD34 CACNA1I POLG2 SIPA1L2 PRODH

6.92e-05125111718ctd:C030935
DrugCapsaicin [404-86-4]; Up 200; 13uM; MCF7; HT_HG-U133A

SEMA6B GRIK5 RUSC2 KAZALD1 KIF5A LTK INPP5J

7.02e-0519611773372_UP
DrugPyrantel tartrate [33401-94-4]; Down 200; 11.2uM; MCF7; HT_HG-U133A

DDX17 GRIK5 CD6 CACNA1H KAZALD1 INPP5J PRODH

7.25e-0519711772260_DN
DrugFlupentixol dihydrochloride cis-(Z) [2413-38-9]; Up 200; 7.8uM; PC3; HT_HG-U133A

RIPOR2 CRTAC1 GRIK5 CD34 ARHGAP28 KAZALD1 PGP

7.25e-0519711776708_UP
DrugFenofibrate [49562-28-9]; Up 200; 11uM; MCF7; HT_HG-U133A

MAGI1 KATNB1 SYNJ2 CACNA1I CACNA1H ARHGEF2 VCPIP1

7.25e-0519711777474_UP
Drugbeta- Belladonnine dichloroethylate [191355-47-2]; Up 200; 6uM; MCF7; HT_HG-U133A

KATNB1 DOK2 CD6 CD34 LRP4 CACNA1I ATP2A3

7.25e-0519711772819_UP
DrugCanrenoic acid potassium salt [2181-04-6]; Down 200; 10uM; MCF7; HT_HG-U133A

FLT4 TNS2 OAS3 GRIK5 SYBU SYNJ2 CACNA1H

7.25e-0519711772228_DN
Drug3-Acetylcoumarin [3949-36-8]; Up 200; 21.2uM; MCF7; HT_HG-U133A

GRIK5 RUSC2 LMO7 CACNA1I KIF5A LTK ARHGEF2

7.25e-0519711773382_UP
DrugCyproterone acetate [427-51-0]; Up 200; 9.6uM; MCF7; HT_HG-U133A

ARHGEF28 TNS2 CRTAC1 CHST1 RUSC2 CD6 CACNA1I

7.49e-0519811776806_UP
DrugDeferoxamine mesylate [138-14-7]; Up 200; 6uM; MCF7; HT_HG-U133A

ARHGEF28 TNS2 GRM3 RUSC2 LRP4 KIF5A SORL1

7.49e-0519811773842_UP
Drugiloprost; Up 200; 1uM; MCF7; HG-U133A

SEMA6B DDX17 ARHGEF28 GRIK5 KAZALD1 ATP2A3 ADAMTSL4

7.49e-051981177488_UP
DrugNicergoline; Down 200; 8.2uM; MCF7; HT_HG-U133A

MYO9B TNS2 GRIK5 SUPT5H ARHGEF2 ATP2A3 VCPIP1

7.73e-0519911772220_DN
DrugPirenzepine dihydrochloride [29868-97-1]; Up 200; 9.4uM; PC3; HT_HG-U133A

RRP1B SIX3 LRP4 CACNA1I KAZALD1 KIF5A PGP

7.73e-0519911775872_UP
DrugPraziquantel [55268-74-1]; Up 200; 12.8uM; HL60; HG-U133A

DDX17 RRP1B HAUS5 RAB11FIP1 PGP ATP2A3 CCS

7.73e-0519911771572_UP
DrugGlafenine hydrochloride [65513-72-6]; Up 200; 9.8uM; MCF7; HT_HG-U133A

FLT4 RBBP5 KATNB1 PTN ARHGEF2 ATP2A3 CCS

7.73e-0519911777418_UP
Drug1,3-dioxoisoindoline-5-carboxamide

CACNA1I CACNA1H

7.83e-0531172CID010679219
DrugSureCN2398996

CACNA1I CACNA1H

7.83e-0531172CID010220069
DrugN-desmethylmethsuximide

CACNA1I CACNA1H

7.83e-0531172CID000092154
DrugHydroxyzine dihydrochloride [2192-20-3]; Up 200; 9uM; MCF7; HT_HG-U133A

ARHGEF28 OAS3 GRIK5 SYNJ2 LRP4 CACNA1H PRODH

7.97e-0520011771524_UP
DrugMethamphetamine

MAGI1 RIPOR2 DDX17 DSP DIS3L OBSCN LGR4 TNS2 GRM3 EFNB1 SYNJ2 LMO7 SUPT5H CCNA1 LTK ARHGEF2 CARNS1 PRODH PCNT

9.35e-05140111719ctd:D008694
DiseaseD dimer measurement

ABCA4 ARHGEF28 LRP4

2.01e-04301123EFO_0004507
Diseaseosteosarcoma

TASOR2 ADAMTS6

3.94e-0481122EFO_0000637
Diseaseintraocular pressure measurement

ABCA4 ZNRF3 ADAMTS6 SYNJ2 LMO7 LRP4 FOXP1 KAZALD1

7.37e-045091128EFO_0004695
Diseasethyroid gland carcinoma (is_marker_for)

FLT4 CD34

9.19e-04121122DOID:3963 (is_marker_for)
Diseaserefractive error

SIX3 SIX6 CD34 CACNA1I KAZALD1 GOLGA8A

1.56e-033261126MONDO_0004892
Diseasealkaline phosphatase measurement

RIPOR2 AKAP8 GAS6 GRIK5 TDP2 ZNRF3 SYNJ2 PKD1 BCAM PGP COG4

1.68e-03101511211EFO_0004533
Diseasecorneal resistance factor

CHST1 ADAMTS6 SYNJ2 CD34 FOXP1 KAZALD1 CCS

1.70e-034511127EFO_0010067
Diseasecortical surface area measurement

MAGI1 AMHR2 RBBP5 MYO9B PERM1 CRTAC1 SYBU SIX3 PKD1 NAV2 FOXP1 ARHGAP28 AGAP1

1.78e-03134511213EFO_0010736
Diseasegrip strength measurement

CRTAC1 EFHB GRM3 PKD1 FOXP1 BCAM

2.23e-033501126EFO_0006941
Diseaseasthma

MAGI1 LAYN MYO9B IFI44 GRM3 TMEM132D SRGAP3 FOXP1 PCNT

2.29e-037511129MONDO_0004979
DiseaseBipolar Disorder

MAGI1 GRIK5 GRM3 STARD9 PGP PRODH PCNT

2.33e-034771127C0005586
Diseaseaspartate aminotransferase measurement

MAGI1 ABCA4 RBBP5 GAS6 OBSCN SRMS CUTC ADAMTS6 TMEM132D AGAP1

2.35e-0390411210EFO_0004736
DiseaseMalignant neoplasm of breast

KRT5 ABCA4 AKAP8 OBSCN PCDH20 CUTC SYNJ2 SRGAP3 ATP2A3 PRODH SORL1

2.60e-03107411211C0006142
DiseaseAnophthalmia-microphthalmia syndrome

SIX3 SIX6

2.86e-03211122cv:C5680330
Diseaseatrial fibrillation

PERM1 CRTAC1 NAV2 PGP KDM1B SORL1

2.97e-033711126EFO_0000275
Diseasecortical thickness

MAGI1 RIPOR2 ABCA4 LGR4 SYBU SRGAP3 PKD1 NAV2 LRP4 FOXP1 AGAP1

3.41e-03111311211EFO_0004840
Diseasemalignant astrocytoma (is_marker_for)

IL16 DOK2

3.43e-03231122DOID:3069 (is_marker_for)

Protein segments in the cluster

PeptideGeneStartEntry
CRDLEEARGLARAGG

TBC1D12

146

O60347
RVEAAGLEGACLEAE

CARD10

651

Q9BWT7
SRDEVNETCGEGDGR

AGAP1

756

Q9UPQ3
SGEELDERSCAAGAR

ADAMTSL4

696

Q6UY14
LGGEGCSTREERALE

ABCA4

881

P78363
SECRDPARERGSLDG

AKAP8

171

O43823
GEDELCDSGRQRGEK

AKAP8

346

O43823
CLGKARERGRDGAID

APOF

206

Q13790
GGGRCSEISAELIRS

COG4

21

Q9H9E3
DSDGRCELVLRAGVA

BHLHE22

151

Q8NFJ8
RGEGTLREDVCADGL

ARHGEF5

241

Q12774
CRRLGEERATEAGSL

ARHGEF2

821

Q92974
GTGTEECGRINEDRG

GRM3

51

Q14832
RGEGTLREDVCADGL

ARHGEF35

241

A5YM69
GRGREAAELARDLTC

CARNS1

61

A5YM72
DDSGEALGLVRRDCL

AMER1

481

Q5JTC6
GERGCQVASRLDEAL

CCDC142

241

Q17RM4
LRLVDGDSRCAGRVE

CD163L1

1036

Q9NR16
SRDRSQGGETLDECG

DMXL1

1526

Q9Y485
CRRLGIFGDTEDVAG

ATP2A3

636

Q93084
VGCDNILGSDAREDR

ADAMTS6

691

Q9UKP5
IREDGSCAIGDLGLA

AMHR2

341

Q16671
DERGRTALSLACERG

ANKRD63

81

C9JTQ0
ISCRGISGGIEDLLD

NWD1

756

Q149M9
TDLGTAELARCGGRE

RASAL3

481

Q86YV0
DCGLGTREGTRTGAE

PTN

61

P21246
LVTGGREGRGCSDVD

ARHGEF28

1326

Q8N1W1
RLTGGADRCEGQVEV

CD6

266

P30203
EIDREALCVEGGGGT

PCDH20

146

Q8N6Y1
RLSDCLRVAEAGGEA

DOK2

61

O60496
AEACESARLGQGRGE

KRBA1

546

A5PL33
LECRLDTGGDLSRGE

KAZALD1

106

Q96I82
ADTDGRLRSGDELIC

MAGI1

876

Q96QZ7
CRRDGGQLVSIESED

LAYN

71

Q6UX15
RKLLEGEECRLSGEG

KRT5

471

P13647
ASGRLLATGGDDCRV

KATNB1

31

Q9BVA0
EEGTSGLGNRSLECL

LTK

801

P29376
ERRSGGGDCSRVAEA

FBXO46

216

Q6PJ61
AGGDDARCVRLSAER

PGP

6

A6NDG6
LLECGGLREGRSNGE

FOXP1

26

Q9H334
DGRLRCGDEIVEISD

IL16

396

Q14005
CSSDITLRGGREGFE

LMO7

261

Q8WWI1
RCKLLDVTGGLGTDE

LAS1L

96

Q9Y4W2
DGDRRVDCSGKGLTA

LGR4

36

Q9BXB1
GSGEGSEALLEICQR

POLG2

61

Q9UHN1
AEIRSLCSGDGLGDT

HAUS5

256

O94927
SRIGERVGLCLDDAG

PCNT

1181

O95613
DGREILTCGRDGEPE

RBBP5

226

Q15291
GEDVELRCELSRAGT

OBSCN

2841

Q5VST9
RDLGSEGGCLRETSE

MYO15B

941

Q96JP2
EGGCLRETSEEAEDR

MYO15B

946

Q96JP2
DSLGLSEKEGGLCRD

IFI44

251

Q8TCB0
FGERCDLIQEGGRIT

KDM1B

461

Q8NB78
AKRDGCGALELEGVE

DIS3L

641

Q8TF46
LRDGEATLEVDGTRG

GAS6

581

Q14393
LLSAERGGGARVCEV

CACNA1I

1006

Q9P0X4
GDGIQLTRSRELDEC

DSP

96

P15924
ELEQGDRDSCSVREG

CCNA1

141

P78396
RCREEVRGILGDGSS

CYP4X1

341

Q8N118
GLTARLGREREIDCG

LINC02875

201

Q86X59
SLEGLENREGGVCRT

EFNB1

141

P98172
RSLIIDEGEDDLGRG

CCS

196

O14618
GRCLEVENRGLAGID

GALNT17

566

Q6IS24
FTGDALLIRGCGRTD

ETHE1

151

O95571
AERGGADRIELCSGL

CUTC

41

Q9NTM9
ADRIELCSGLSEGGT

CUTC

46

Q9NTM9
GIRVGLGKEDSRCGE

EFHB

31

Q8N7U6
RLAGEEAALGAELCE

KIF5A

381

Q12840
GVTACDIDGDGREEI

CRTAC1

116

Q9NQ79
AEGREGEACGTVGLL

EMC10

41

Q5UCC4
QDECDRRLRGVKDGG

DDX17

581

Q92841
DGLLRIGAVNCGDDR

DNAJC10

176

Q8IXB1
DDQTVCGRGERLALA

GRIK5

31

Q16478
VREGDTVQLLCRGDG

BCAM

281

P50895
RRGQCGERESLLSGE

CACNA1H

1156

O95180
GLLEGREGALTSGCD

SLC45A1

451

Q9Y2W3
REGALTSGCDGDILR

SLC45A1

456

Q9Y2W3
TSGCDGDILRVGSLD

SLC45A1

461

Q9Y2W3
AGGRSRRGCEEEDVA

PERM1

66

Q5SV97
RGEGLARVLCGEEQA

CD34

206

P28906
FTLTVLGRSGEEEGC

PKD1

2446

P98161
LGRSGEEEGCASIRL

PKD1

2451

P98161
SFGRGTDLRDGCDVE

OAS3

461

Q9Y6K5
LKDLEVGGSGRRCSD

GOLGA8A

31

A7E2F4
EACPASEEALGRERG

RUSC2

1326

Q8N2Y8
SVERLLGVLAESCGG

TARS2

591

Q9BW92
GEADRLVLGEGLCDF

RAB11FIP1

1016

Q6WKZ4
CSGGDVEARLEGELV

SORL1

736

Q92673
GLSDERGRDDCGTFE

RRP1B

276

Q14684
TREVRGSCRLQGDLG

TMEM132D

176

Q14C87
GRLGAEGDCSVLLEA

SYNJ2

11

O15056
EGDCSVLLEARGRDD

SYNJ2

16

O15056
RGRDDCLLFEAGTVA

SYNJ2

26

O15056
RCLLEARGGASEEAL

SYNJ2

1181

O15056
RCLALEAEESSGEEG

SYNPO

31

Q8N3V7
EGPGSRDTSCERLET

NAV2

441

Q8IVL1
LDDTGECSARKEGGR

NAV2

2001

Q8IVL1
REGTGLTEGCLVSVD

SMYD1

116

Q8NB12
LRCIEASGRVSDDGF

PRODH

216

O43272
QGSGPLECDGARERE

SIPA1L2

1156

Q9P2F8
CETLEETGDIERLGR

SIX3

96

O95343
GVCETLEESGDVERL

SIX6

16

O95475
GEDREATGVLLSIDG

SUPT5H

1046

O00267
EDGLDGCQILDAGRE

STARD9

3236

Q9P2P6
SVRRGDRLCALEEGG

SRMS

71

Q9H3Y6
GESEGCRSFLDGSLE

RIPOR2

591

Q9Y4F9
GLAEAGLAERLCEES

CHST1

36

O43916
VGDCDLRDRAEGALL

CLEC14A

466

Q86T13
LRDVQTDCTRTGLGG

INPP5J

521

Q15735
GECDISGAGRLGLEE

PLPPR4

11

Q7Z2D5
GDCTGLLRASLSEDR

SEMA6B

576

Q9H3T3
TLGEGERAECGTTRP

SRGAP3

466

O43295
TGEGADRELLVGDSI

SYBU

421

Q9NX95
ESGLESEGIFRLSGC

ARHGAP28

411

Q9P2N2
LDDQSCUGSGRTLRE

SELENON

456

Q9NZV5
EDTGVVRDCEGTDAR

FLT4

76

P35916
GDTNLRDREVTRCGG

TDP2

261

O95551
LGADESEEEGRRGSL

NRDC

81

O43847
LEEDGGCVIGGDRSL

VCPIP1

391

Q96JH7
VTGLECVGDRLLAGE

WDR6

21

Q9NNW5
SKGRREGSCGALDTL

ZNRF3

271

Q9ULT6
ARLRCADSGADARGE

TPBGL

281

P0DKB5
LRAEAGSETLGRDGE

TASOR2

1801

Q5VWN6
ARRGFGLDGLCRVED

ZNF584

91

Q8IVC4
AERQELDRLLGGCGV

TNS2

536

Q63HR2
EEVEGRCSERDARLG

LRP4

1691

O75096
ESLLEERAGRGASEG

MYO9B

2006

Q13459