Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionpeptide lactyltransferase (CoA-dependent) activity

CREBBP EP300

1.63e-062262GO:0120300
GeneOntologyMolecularFunctionhistone H3K27 acetyltransferase activity

CREBBP EP300

1.63e-062262GO:0044017
GeneOntologyMolecularFunctionhistone H3K18 acetyltransferase activity

CREBBP EP300

4.89e-063262GO:0043993
GeneOntologyMolecularFunctiontranscription coactivator activity

BCL9L KMT2C BCL9 CREBBP EP300

3.94e-05303265GO:0003713
GeneOntologyMolecularFunctiontranscription coregulator activity

BCL9L KMT2C BCL9 CREBBP EP300 MED8

6.89e-05562266GO:0003712
GeneOntologyMolecularFunctionhistone H3 acetyltransferase activity

CREBBP EP300

1.69e-0415262GO:0010484
GeneOntologyMolecularFunctionhistone modifying activity

KMT2C SETD2 CREBBP EP300

2.07e-04229264GO:0140993
GeneOntologyMolecularFunctionN-acyltransferase activity

ALAS1 CREBBP EP300

3.09e-04102263GO:0016410
GeneOntologyMolecularFunctionperoxisome proliferator activated receptor binding

CREBBP EP300

3.37e-0421262GO:0042975
GeneOntologyMolecularFunctionbeta-catenin binding

BCL9L BCL9 EP300

4.97e-04120263GO:0008013
GeneOntologyMolecularFunctionbHLH transcription factor binding

CREBBP EP300

1.06e-0337262GO:0043425
GeneOntologyMolecularFunctionmolecular adaptor activity

BCL9L KMT2C BCL9 CNOT1 CREBBP EP300 MED8

1.37e-031356267GO:0060090
GeneOntologyMolecularFunctionhistone H3 methyltransferase activity

KMT2C SETD2

1.49e-0344262GO:0140938
GeneOntologyMolecularFunctionRNA polymerase II-specific DNA-binding transcription factor binding

REST CNOT1 CREBBP EP300

1.95e-03417264GO:0061629
GeneOntologyMolecularFunctionhistone acetyltransferase activity

CREBBP EP300

2.00e-0351262GO:0004402
GeneOntologyMolecularFunctiontranscription coactivator binding

CREBBP EP300

2.24e-0354262GO:0001223
GeneOntologyMolecularFunctionpeptide-lysine-N-acetyltransferase activity

CREBBP EP300

2.32e-0355262GO:0061733
GeneOntologyMolecularFunctionpeptide N-acetyltransferase activity

CREBBP EP300

2.75e-0360262GO:0034212
GeneOntologyMolecularFunctionacyltransferase activity

KMT2C ALAS1 CREBBP EP300 MED8

2.90e-03775265GO:0016746
GeneOntologyMolecularFunctionprotein-macromolecule adaptor activity

BCL9L KMT2C BCL9 CREBBP EP300 MED8

3.20e-031160266GO:0030674
GeneOntologyMolecularFunctionprotein-lysine N-methyltransferase activity

KMT2C SETD2

3.52e-0368262GO:0016279
GeneOntologyMolecularFunctionacyltransferase activity, transferring groups other than amino-acyl groups

ALAS1 CREBBP EP300

3.55e-03238263GO:0016747
GeneOntologyMolecularFunctionlysine N-methyltransferase activity

KMT2C SETD2

3.63e-0369262GO:0016278
GeneOntologyMolecularFunctionhistone methyltransferase activity

KMT2C SETD2

3.83e-0371262GO:0042054
GeneOntologyMolecularFunctionp53 binding

CREBBP EP300

4.49e-0377262GO:0002039
GeneOntologyMolecularFunctionN-acetyltransferase activity

CREBBP EP300

4.61e-0378262GO:0008080
GeneOntologyMolecularFunctiondamaged DNA binding

CREBBP EP300

5.32e-0384262GO:0003684
GeneOntologyMolecularFunctionSMAD binding

CREBBP EP300

5.57e-0386262GO:0046332
GeneOntologyMolecularFunctionDNA-binding transcription factor binding

REST CNOT1 CREBBP EP300

6.41e-03582264GO:0140297
GeneOntologyMolecularFunctionprotein methyltransferase activity

KMT2C SETD2

7.90e-03103262GO:0008276
GeneOntologyMolecularFunctionacetyltransferase activity

CREBBP EP300

8.05e-03104262GO:0016407
GeneOntologyMolecularFunctionN-methyltransferase activity

KMT2C SETD2

8.20e-03105262GO:0008170
GeneOntologyMolecularFunctiontranscription coregulator binding

CREBBP EP300

1.42e-02140262GO:0001221
GeneOntologyBiologicalProcessN-terminal peptidyl-lysine acetylation

CREBBP EP300

9.15e-064262GO:0018076
GeneOntologyBiologicalProcessstem cell population maintenance

BCL9L REST BCL9 CNOT1 CREBBP

1.04e-05237265GO:0019827
GeneOntologyBiologicalProcessmaintenance of cell number

BCL9L REST BCL9 CNOT1 CREBBP

1.15e-05242265GO:0098727
GeneOntologyBiologicalProcessregulation of transforming growth factor beta receptor signaling pathway

BCL9L BCL9 CREBBP EP300

9.27e-05192264GO:0017015
GeneOntologyBiologicalProcessregulation of cellular response to transforming growth factor beta stimulus

BCL9L BCL9 CREBBP EP300

9.84e-05195264GO:1903844
GeneOntologyBiologicalProcesscell junction organization

DGKB NRXN3 REST PTPRD TNS1 FMN1 IQSEC2

1.53e-04974267GO:0034330
GeneOntologyBiologicalProcessN-terminal protein amino acid acetylation

CREBBP EP300

1.81e-0416262GO:0006474
GeneOntologyBiologicalProcessregulation of cellular response to heat

CREBBP EP300

1.81e-0416262GO:1900034
GeneOntologyBiologicalProcesssomatic stem cell population maintenance

BCL9L REST BCL9

3.32e-04108263GO:0035019
GeneOntologyBiologicalProcesstransforming growth factor beta receptor signaling pathway

BCL9L BCL9 CREBBP EP300

3.72e-04276264GO:0007179
GeneOntologyBiologicalProcessstimulatory C-type lectin receptor signaling pathway

CREBBP EP300

3.80e-0423262GO:0002223
GeneOntologyBiologicalProcesscellular response to lectin

CREBBP EP300

3.80e-0423262GO:1990858
GeneOntologyBiologicalProcessresponse to lectin

CREBBP EP300

3.80e-0423262GO:1990840
GeneOntologyBiologicalProcesspeptidyl-lysine acetylation

CREBBP EP300

5.66e-0428262GO:0018394
GeneOntologyBiologicalProcessN-terminal protein amino acid modification

CREBBP EP300

6.07e-0429262GO:0031365
GeneOntologyBiologicalProcesscell junction assembly

NRXN3 PTPRD TNS1 FMN1 IQSEC2

6.39e-04569265GO:0034329
GeneOntologyBiologicalProcesspositive regulation of cell junction assembly

PTPRD FMN1 IQSEC2

6.52e-04136263GO:1901890
GeneOntologyBiologicalProcessmyoblast differentiation

BCL9L REST BCL9

6.52e-04136263GO:0045445
GeneOntologyBiologicalProcesscellular response to transforming growth factor beta stimulus

BCL9L BCL9 CREBBP EP300

7.79e-04336264GO:0071560
GeneOntologyBiologicalProcessnegative regulation of miRNA metabolic process

REST EP300

8.36e-0434262GO:2000629
GeneOntologyBiologicalProcesspostsynaptic density assembly

NRXN3 PTPRD

8.36e-0434262GO:0097107
GeneOntologyBiologicalProcessresponse to transforming growth factor beta

BCL9L BCL9 CREBBP EP300

8.41e-04343264GO:0071559
GeneOntologyBiologicalProcessregulation of transmembrane receptor protein serine/threonine kinase signaling pathway

BCL9L BCL9 CREBBP EP300

8.78e-04347264GO:0090092
GeneOntologyBiologicalProcesspositive regulation of cellular response to transforming growth factor beta stimulus

CREBBP EP300

8.86e-0435262GO:1903846
GeneOntologyBiologicalProcesspositive regulation of transforming growth factor beta receptor signaling pathway

CREBBP EP300

8.86e-0435262GO:0030511
GeneOntologyBiologicalProcesspeptidyl-lysine modification

SETD2 CREBBP EP300

1.08e-03162263GO:0018205
GeneOntologyBiologicalProcessnuclear transport

TMCO6 SETD2 PABPN1 EP300

1.21e-03378264GO:0051169
GeneOntologyBiologicalProcessnucleocytoplasmic transport

TMCO6 SETD2 PABPN1 EP300

1.21e-03378264GO:0006913
GeneOntologyBiologicalProcessface morphogenesis

CREBBP EP300

1.22e-0341262GO:0060325
GeneOntologyBiologicalProcessprotein-DNA complex organization

KMT2C SETD2 REST CREBBP EP300 MED8

1.27e-03999266GO:0071824
GeneOntologyBiologicalProcesspositive regulation of transcription by RNA polymerase II

BCL9L KMT2C REST BCL9 CREBBP EP300 MED8

1.31e-031390267GO:0045944
GeneOntologyBiologicalProcesspostsynaptic specialization assembly

NRXN3 PTPRD

1.40e-0344262GO:0098698
GeneOntologyBiologicalProcesssynapse organization

DGKB NRXN3 REST PTPRD IQSEC2

1.47e-03685265GO:0050808
GeneOntologyBiologicalProcessexcitatory synapse assembly

NRXN3 PTPRD

1.53e-0346262GO:1904861
GeneOntologyBiologicalProcessresponse to organic cyclic compound

SETD2 ALAS1 REST CNOT1 CREBBP EP300

1.63e-031048266GO:0014070
GeneOntologyBiologicalProcessregulation of cellular response to growth factor stimulus

BCL9L BCL9 CREBBP EP300

1.66e-03412264GO:0090287
GeneOntologyBiologicalProcesshead morphogenesis

CREBBP EP300

1.66e-0348262GO:0060323
GeneOntologyBiologicalProcessneurotransmitter receptor localization to postsynaptic specialization membrane

NRXN3 IQSEC2

1.73e-0349262GO:0099645
GeneOntologyBiologicalProcessprotein localization to postsynaptic specialization membrane

NRXN3 IQSEC2

1.73e-0349262GO:0099633
GeneOntologyCellularComponenttranscription regulator complex

BCL9L REST BCL9 CREBBP EP300 MED8

7.41e-05596266GO:0005667
GeneOntologyCellularComponentbeta-catenin-TCF complex

BCL9L BCL9

1.15e-0413262GO:1990907
GeneOntologyCellularComponentRNA polymerase II transcription regulator complex

BCL9L BCL9 CREBBP MED8

3.35e-04272264GO:0090575
GeneOntologyCellularComponentSchaffer collateral - CA1 synapse

DGKB PTPRD IQSEC2

9.17e-04155263GO:0098685
HumanPhenoSquare face

CREBBP EP300 IQSEC2

2.11e-061693HP:0000321
HumanPhenoAortic isthmus hypoplasia

CREBBP EP300

2.78e-06292HP:0034227
HumanPhenoPlantar crease between first and second toes

CREBBP EP300

2.78e-06292HP:0008107
HumanPhenoHigh axial triradius

CREBBP EP300

2.78e-06292HP:0001042
HumanPhenoHumoral immunodeficiency

CREBBP EP300

8.32e-06392HP:0005363
HumanPhenoProminent nasal septum

CREBBP EP300

8.32e-06392HP:0005322
HumanPhenoRadial deviation of thumb terminal phalanx

CREBBP EP300

8.32e-06392HP:0005895
HumanPhenoLaryngeal cartilage malformation

CREBBP EP300

8.32e-06392HP:0008752
HumanPhenoPhobia

CREBBP EP300

8.32e-06392HP:5200232
HumanPhenoAgoraphobia

CREBBP EP300

8.32e-06392HP:0000756
HumanPhenoTrichiasis

CREBBP EP300

1.66e-05492HP:0001128
HumanPhenoWidened distal phalanges

CREBBP EP300

1.66e-05492HP:0006200
HumanPhenoVisceral hemangioma

CREBBP EP300

1.66e-05492HP:0410266
HumanPhenoTalon cusp

CREBBP EP300

1.66e-05492HP:0011087
HumanPhenoVascular ring

CREBBP EP300

1.66e-05492HP:0010775
HumanPhenoHepatic hemangioma

CREBBP EP300

1.66e-05492HP:0031207
HumanPhenoSyringomyelia

SETD2 CREBBP EP300

2.03e-053393HP:0003396
HumanPhenoAbnormality of the distal phalanx of the thumb

CNOT1 CREBBP EP300

2.65e-053693HP:0009617
HumanPhenoPapillary cystadenoma of the epididymis

CREBBP EP300

2.77e-05592HP:0009715
HumanPhenoSupernumerary cusp

CREBBP EP300

2.77e-05592HP:0033777
HumanPhenoEpididymal neoplasm

CREBBP EP300

2.77e-05592HP:0030421
HumanPhenoAuditory sensitivity

CREBBP EP300 IQSEC2

2.88e-053793HP:0025112
HumanPhenoAuditory hypersensitivity

CREBBP EP300 IQSEC2

2.88e-053793HP:5200060
HumanPhenoNatal tooth

KMT2C CREBBP EP300

3.12e-053893HP:0000695
HumanPhenoLarge foramen magnum

CREBBP EP300

4.15e-05692HP:0002700
HumanPhenoSpinal cord lesion

SETD2 CREBBP EP300

5.57e-054693HP:0100561
HumanPhenoAdvanced eruption of teeth

KMT2C CREBBP EP300

5.57e-054693HP:0006288
HumanPhenoDeviated nasal septum

CREBBP EP300

5.80e-05792HP:0004411
HumanPhenoChiari type I malformation

SETD2 CREBBP EP300

6.34e-054893HP:0007099
HumanPhenoPilomatrixoma

CREBBP EP300

9.93e-05992HP:0030434
HumanPhenoCervical cord compression

CREBBP EP300

9.93e-05992HP:0002341
HumanPhenoLow hanging columella

SETD2 CREBBP EP300

1.01e-045693HP:0009765
HumanPhenoFrontal hirsutism

CREBBP EP300

1.24e-041092HP:0011335
HumanPhenoSleep apnea

PABPN1 CREBBP EP300 IQSEC2

1.26e-0416894HP:0010535
HumanPhenoSleep-related breathing disorders

PABPN1 CREBBP EP300 IQSEC2

1.29e-0416994HP:5200283
HumanPhenoAbnormal subclavian artery morphology

CREBBP EP300

1.51e-041192HP:0031251
HumanPhenoPrecocious puberty

KMT2C CREBBP EP300 IQSEC2

1.88e-0418694HP:0000826
HumanPhenoEarly onset of sexual maturation

KMT2C CREBBP EP300 IQSEC2

2.00e-0418994HP:0100000
HumanPhenoConductive hearing impairment

SETD2 CNOT1 CREBBP EP300 IQSEC2

2.02e-0437395HP:0000405
HumanPhenoFacial grimacing

CREBBP EP300

2.14e-041392HP:0000273
HumanPhenoKeloids

CREBBP EP300

2.14e-041392HP:0010562
HumanPhenoFunctional abnormality of the middle ear

SETD2 CNOT1 CREBBP EP300 IQSEC2

2.38e-0438695HP:0011452
HumanPhenoParietal foramina

CREBBP EP300

2.50e-041492HP:0002697
HumanPhenoDuplication of phalanx of hallux

CREBBP EP300

2.50e-041492HP:0010066
HumanPhenoHypoplastic aortic arch

CREBBP EP300

2.50e-041492HP:0012304
HumanPhenoSocial and occupational deterioration

CREBBP EP300

2.88e-041592HP:0007086
HumanPhenoDuplication of phalanx of toe

CREBBP EP300

2.88e-041592HP:0010181
HumanPhenoSelf-injurious behavior

KMT2C CREBBP EP300 IQSEC2

3.00e-0421094HP:0100716
HumanPhenoSupernumerary tooth

KMT2C CREBBP EP300

3.50e-048593HP:0011069
HumanPhenoPremature thelarche

CREBBP EP300

3.72e-041792HP:0010314
HumanPhenoTall stature

KMT2C SETD2 REST CNOT1

3.92e-0422594HP:0000098
HumanPhenoAbnormal midface morphology

KMT2C SETD2 CNOT1 CREBBP EP300 IQSEC2

3.95e-0470496HP:0000309
HumanPhenoFacial hirsutism

CREBBP EP300

4.18e-041892HP:0009937
HumanPhenoSkin appendage neoplasm

CREBBP EP300

4.18e-041892HP:0012842
HumanPhenoAbnormality of dental eruption

KMT2C CREBBP EP300 IQSEC2

5.02e-0424094HP:0006292
HumanPhenoAbnormal columella morphology

SETD2 CREBBP EP300

5.17e-049793HP:0009929
HumanPhenoAbsent earlobe

CREBBP EP300

5.19e-042092HP:0000387
HumanPhenoLocalized hirsutism

CREBBP EP300

5.73e-042192HP:0009889
HumanPhenoDeep plantar creases

CREBBP EP300

5.73e-042192HP:0001869
HumanPhenoCorneal scarring

CREBBP EP300

5.73e-042192HP:0000559
HumanPhenoEnamel hypoplasia

GALNT3 CREBBP EP300

6.35e-0410493HP:0006297
HumanPhenoAplasia/Hypoplasia of the corpus callosum

KMT2C SETD2 CNOT1 CREBBP EP300 IQSEC2

6.62e-0477296HP:0007370
HumanPhenoAbnormal foramen magnum morphology

CREBBP EP300

6.89e-042392HP:0002699
HumanPhenoAgenesis of permanent teeth

CREBBP EP300

6.89e-042392HP:0006349
HumanPhenoChiari malformation

SETD2 CREBBP EP300

6.90e-0410793HP:0002308
HumanPhenoAbnormality of the incisor

CNOT1 CREBBP EP300

7.09e-0410893HP:0000676
HumanPhenoAutism

SETD2 CREBBP EP300 IQSEC2

7.23e-0426494HP:0000717
HumanPhenoIncreased body weight

KMT2C SETD2 CREBBP EP300 IQSEC2

7.39e-0449195HP:0004324
HumanPhenoSimple ear

CREBBP EP300

7.51e-042492HP:0020206
HumanPhenoBroad hallux phalanx

CREBBP EP300

7.51e-042492HP:0010059
HumanPhenoShawl scrotum

CREBBP EP300

8.15e-042592HP:0000049
HumanPhenoAbnormal nasal septum morphology

SETD2 CREBBP EP300

8.53e-0411593HP:0000419
HumanPhenoMinor feet anomalies

CREBBP EP300

8.82e-042692HP:0010613
HumanPhenoAbnormal feet morphology

CREBBP EP300

8.82e-042692HP:0010611
HumanPhenoPhonophobia

CREBBP EP300

8.82e-042692HP:0002183
HumanPhenoPerimembranous ventricular septal defect

CREBBP EP300

8.82e-042692HP:0011682
HumanPhenoAggressive behavior

KMT2C SETD2 CREBBP EP300 IQSEC2

9.32e-0451695HP:0000718
HumanPhenoAbnormal aggressive, impulsive or violent behavior

KMT2C SETD2 CREBBP EP300 IQSEC2

9.32e-0451695HP:0006919
HumanPhenoFlared iliac wing

CREBBP EP300

9.52e-042792HP:0002869
HumanPhenoBroad distal phalanx of finger

CREBBP EP300

9.52e-042792HP:0009836
HumanPhenoHypermetropia

KMT2C CREBBP EP300 IQSEC2

1.01e-0328894HP:0000540
HumanPhenoShort palpebral fissure

SETD2 CREBBP EP300

1.01e-0312293HP:0012745
HumanPhenoShort columella

CREBBP EP300

1.10e-032992HP:0002000
HumanPhenoAbnormal parietal bone morphology

CREBBP EP300

1.10e-032992HP:0002696
HumanPhenoBroad eyebrow

CREBBP EP300

1.10e-032992HP:0011229
HumanPhenoHypoplasia of teeth

GALNT3 CREBBP EP300

1.11e-0312693HP:0000685
HumanPhenoAbnormal dental morphology

GALNT3 CREBBP EP300 IQSEC2

1.16e-0329994HP:0006482
HumanPhenoAvascular necrosis of the capital femoral epiphysis

CREBBP EP300

1.18e-033092HP:0005743
HumanPhenoAbnormal epididymis morphology

CREBBP EP300

1.18e-033092HP:0009714
HumanPhenoPreaxial foot polydactyly

CREBBP EP300

1.18e-033092HP:0001841
HumanPhenoHypoplasia of the maxilla

SETD2 CREBBP EP300

1.22e-0313093HP:0000327
HumanPhenoHypoplastic iliac wing

CREBBP EP300

1.26e-033192HP:0002866
HumanPhenoThin corpus callosum

KMT2C SETD2 CNOT1 CREBBP EP300 IQSEC2

1.27e-0386896HP:0033725
HumanPhenoAbnormal pattern of respiration

SETD2 REST PABPN1 CREBBP EP300 IQSEC2

1.30e-0387296HP:0002793
HumanPhenoAplasia/Hypoplasia of the maxilla

SETD2 CREBBP EP300

1.30e-0313393HP:0009117
HumanPhenoAbnormal earlobe morphology

KMT2C CREBBP EP300

1.42e-0313793HP:0000363
HumanPhenoFrontal upsweep of hair

CREBBP EP300

1.42e-033392HP:0002236
HumanPhenoAbnormal branching pattern of the aortic arch

CREBBP EP300

1.42e-033392HP:0011587
HumanPhenoNeoplasm of the liver

REST CREBBP EP300

1.51e-0314093HP:0002896
HumanPhenoAspiration

CREBBP EP300

1.51e-033492HP:0002835
Domain-

CREBBP EP300

1.72e-0622521.10.246.20
Domainzf-TAZ

CREBBP EP300

1.72e-062252PF02135
DomainZF_TAZ

CREBBP EP300

1.72e-062252PS50134
DomainBCL9_beta-catenin-bd_dom

BCL9L BCL9

1.72e-062252IPR024670
DomainNuc_rcpt_coact_CREBbp

CREBBP EP300

1.72e-062252IPR014744
DomainHAT_KAT11

CREBBP EP300

1.72e-062252PF08214
DomainKIX

CREBBP EP300

1.72e-062252PS50952
DomainBCL9

BCL9L BCL9

1.72e-062252PF11502
DomainZnF_TAZ

CREBBP EP300

1.72e-062252SM00551
DomainCBP_P300_HAT

CREBBP EP300

1.72e-062252IPR031162
DomainHistone_AcTrfase_Rtt109/CBP

CREBBP EP300

1.72e-062252IPR013178
DomainDUF902

CREBBP EP300

1.72e-062252PF06001
Domain-

CREBBP EP300

1.72e-0622521.20.1020.10
DomainRING_CBP-p300

CREBBP EP300

1.72e-062252IPR010303
DomainKAT11

CREBBP EP300

1.72e-062252SM01250
Domain-

CREBBP EP300

1.72e-0622521.10.1630.10
DomainZnf_TAZ

CREBBP EP300

1.72e-062252IPR000197
DomainKIX_dom

CREBBP EP300

1.72e-062252IPR003101
DomainCreb_binding

CREBBP EP300

1.72e-062252PF09030
DomainKIX

CREBBP EP300

1.72e-062252PF02172
DomainBcl-9

BCL9L BCL9

1.72e-062252IPR015668
DomainCBP_P300_HAT

CREBBP EP300

1.72e-062252PS51727
DomainNuc_rcpt_coact

CREBBP EP300

2.57e-056252IPR009110
DomainINT_SG_DDX_CT_C

CT45A10 CT45A7

4.79e-058252PF15300
DomainINT_SG_DDX_CT_C

CT45A10 CT45A7

4.79e-058252IPR029307
DomainPost-SET_dom

KMT2C SETD2

2.04e-0416252IPR003616
DomainPostSET

KMT2C SETD2

2.04e-0416252SM00508
DomainPOST_SET

KMT2C SETD2

2.04e-0416252PS50868
DomainZF_ZZ_2

CREBBP EP300

2.60e-0418252PS50135
DomainZF_ZZ_1

CREBBP EP300

2.60e-0418252PS01357
DomainZZ

CREBBP EP300

2.60e-0418252PF00569
DomainZnf_ZZ

CREBBP EP300

2.90e-0419252IPR000433
DomainZnF_ZZ

CREBBP EP300

2.90e-0419252SM00291
DomainBromodomain_CS

CREBBP EP300

5.48e-0426252IPR018359
DomainBROMODOMAIN_1

CREBBP EP300

1.11e-0337252PS00633
DomainBromodomain

CREBBP EP300

1.17e-0338252PF00439
DomainBROMODOMAIN_2

CREBBP EP300

1.37e-0341252PS50014
DomainSET

KMT2C SETD2

1.37e-0341252PF00856
DomainBROMO

CREBBP EP300

1.43e-0342252SM00297
DomainBromodomain

CREBBP EP300

1.43e-0342252IPR001487
Domain-

CREBBP EP300

1.43e-03422521.20.920.10
DomainSET

KMT2C SETD2

1.72e-0346252SM00317
DomainSET_dom

KMT2C SETD2

2.03e-0350252IPR001214
DomainSET

KMT2C SETD2

2.03e-0350252PS50280
DomainPTPc_motif

PTPRD TNS1

2.81e-0359252SM00404
DomainTyr_Pase_cat

PTPRD TNS1

2.81e-0359252IPR003595
DomainC1

DGKB KMT2C

3.40e-0365252SM00109
DomainPE/DAG-bd

DGKB KMT2C

3.50e-0366252IPR002219
Domain-

PTPRD TNS1

6.69e-03922523.90.190.10
DomainProt-tyrosine_phosphatase-like

PTPRD TNS1

7.71e-0399252IPR029021
PathwayWP_PATHWAYS_AFFECTED_IN_ADENOID_CYSTIC_CARCINOMA

KMT2C SETD2 CREBBP EP300

1.89e-0665204M39682
PathwayREACTOME_FORMATION_OF_THE_BETA_CATENIN_TCF_TRANSACTIVATING_COMPLEX

BCL9L BCL9 EP300

6.22e-0626203MM14793
PathwayREACTOME_FORMATION_OF_THE_BETA_CATENIN_TCF_TRANSACTIVATING_COMPLEX

BCL9L BCL9 CREBBP EP300

7.27e-0691204M27101
PathwayWP_TYPE_2_PAPILLARY_RENAL_CELL_CARCINOMA

SETD2 CREBBP EP300

1.42e-0534203M39771
PathwayBIOCARTA_PELP1_PATHWAY

CREBBP EP300

1.91e-055202MM1575
PathwayREACTOME_NFE2L2_REGULATING_INFLAMMATION_ASSOCIATED_GENES

CREBBP EP300

1.91e-055202M48020
PathwayREACTOME_LRR_FLII_INTERACTING_PROTEIN_1_LRRFIP1_ACTIVATES_TYPE_I_IFN_PRODUCTION

CREBBP EP300

1.91e-055202M27228
PathwayREACTOME_NFE2L2_REGULATING_ER_STRESS_ASSOCIATED_GENES

CREBBP EP300

1.91e-055202M48023
PathwayREACTOME_REGULATION_OF_LIPID_METABOLISM_BY_PPARALPHA

ALAS1 CREBBP EP300 MED8

2.04e-05118204M27316
PathwayREACTOME_MATERNAL_TO_ZYGOTIC_TRANSITION_MZT

PABPN1 CNOT1 CREBBP EP300

2.81e-05128204M48019
PathwayBIOCARTA_PELP1_PATHWAY

CREBBP EP300

2.86e-056202M22062
PathwayREACTOME_CHROMATIN_MODIFYING_ENZYMES

KMT2C SETD2 REST CREBBP EP300

3.15e-05272205M29619
PathwayBIOCARTA_PPARG_PATHWAY

CREBBP EP300

4.00e-057202MM1573
PathwayBIOCARTA_PPARG_PATHWAY

CREBBP EP300

5.33e-058202M22058
PathwayREACTOME_NFE2L2_REGULATING_MDR_ASSOCIATED_ENZYMES

CREBBP EP300

5.33e-058202M48022
PathwayREACTOME_REGULATION_OF_NFE2L2_GENE_EXPRESSION

CREBBP EP300

5.33e-058202M48024
PathwayREACTOME_NFE2L2_REGULATES_PENTOSE_PHOSPHATE_PATHWAY_GENES

CREBBP EP300

5.33e-058202M46443
PathwayKEGG_MEDICUS_REFERENCE_TLR3_IRF3_SIGNALING_PATHWAY

CREBBP EP300

6.84e-059202M47451
PathwayREACTOME_REGULATION_OF_FOXO_TRANSCRIPTIONAL_ACTIVITY_BY_ACETYLATION

CREBBP EP300

8.55e-0510202M27945
PathwayBIOCARTA_CARM1_PATHWAY

CREBBP EP300

1.04e-0411202MM1521
PathwayREACTOME_NFE2L2_REGULATING_TUMORIGENIC_GENES

CREBBP EP300

1.04e-0411202M48021
PathwayREACTOME_REGULATION_OF_GENE_EXPRESSION_BY_HYPOXIA_INDUCIBLE_FACTOR

CREBBP EP300

1.04e-0411202M26924
PathwayKEGG_HUNTINGTONS_DISEASE

DNAH3 REST CREBBP EP300

1.11e-04182204M13486
PathwayBIOCARTA_CARM1_PATHWAY

CREBBP EP300

1.25e-0412202M7968
PathwayREACTOME_ACTIVATION_OF_THE_TFAP2_AP_2_FAMILY_OF_TRANSCRIPTION_FACTORS

CREBBP EP300

1.25e-0412202M27765
PathwayREACTOME_RUNX3_REGULATES_NOTCH_SIGNALING

CREBBP EP300

1.72e-0414202M27808
PathwayBIOCARTA_RELA_PATHWAY

CREBBP EP300

1.99e-0415202MM1339
PathwayBIOCARTA_RELA_PATHWAY

CREBBP EP300

1.99e-0415202M10183
PathwayBIOCARTA_PITX2_PATHWAY

CREBBP EP300

1.99e-0415202MM1439
PathwayREACTOME_TRAF3_DEPENDENT_IRF_ACTIVATION_PATHWAY

CREBBP EP300

1.99e-0415202M953
PathwayREACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION

CREBBP EP300 MED8

2.16e-0484203M1008
PathwayBIOCARTA_IL7_PATHWAY

CREBBP EP300

2.27e-0416202M1296
PathwayBIOCARTA_IL7_PATHWAY

CREBBP EP300

2.27e-0416202MM1420
PathwayBIOCARTA_PITX2_PATHWAY

CREBBP EP300

2.27e-0416202M8516
PathwayREACTOME_REGULATION_OF_GENE_EXPRESSION_IN_LATE_STAGE_BRANCHING_MORPHOGENESIS_PANCREATIC_BUD_PRECURSOR_CELLS

CREBBP EP300

2.27e-0416202M27121
PathwayREACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_CELL_DEATH_GENES

CREBBP EP300

2.27e-0416202M27940
PathwayWP_CLEAR_CELL_RENAL_CELL_CARCINOMA_PATHWAYS

SETD2 CREBBP EP300

2.32e-0486203M39375
PathwayBIOCARTA_TGFB_PATHWAY

CREBBP EP300

2.57e-0417202MM1509
PathwayREACTOME_ZYGOTIC_GENOME_ACTIVATION_ZGA

CREBBP EP300

2.57e-0417202M48025
PathwayREACTOME_TCF_DEPENDENT_SIGNALING_IN_RESPONSE_TO_WNT

BCL9L BCL9 CREBBP EP300

2.86e-04233204M27099
PathwayREACTOME_RORA_ACTIVATES_GENE_EXPRESSION

CREBBP EP300

2.89e-0418202M26942
PathwayBIOCARTA_TGFB_PATHWAY

CREBBP EP300

3.22e-0419202M18933
PathwayREACTOME_NFE2L2_REGULATING_ANTI_OXIDANT_DETOXIFICATION_ENZYMES

CREBBP EP300

3.22e-0419202M46442
PathwayREACTOME_RSV_HOST_INTERACTIONS

CREBBP EP300 MED8

3.41e-0498203M48247
PathwayREACTOME_NOTCH4_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION

CREBBP EP300

3.58e-0420202M27881
PathwayWP_HEMATOPOIETIC_STEM_CELL_GENE_REGULATION_BY_GABP_ALPHABETA_COMPLEX

CREBBP EP300

3.95e-0421202M39593
PathwayREACTOME_CD209_DC_SIGN_SIGNALING

CREBBP EP300

3.95e-0421202M27485
PathwayBIOCARTA_NTHI_PATHWAY

CREBBP EP300

4.34e-0422202MM1443
PathwayBIOCARTA_VDR_PATHWAY

CREBBP EP300

4.34e-0422202MM1370
PathwayBIOCARTA_NTHI_PATHWAY

CREBBP EP300

4.75e-0423202M2821
PathwayREACTOME_ADIPOGENESIS

CREBBP EP300 MED8

4.78e-04110203M48259
PathwayBIOCARTA_VDR_PATHWAY

CREBBP EP300

5.18e-0424202M13404
PathwayREACTOME_NOTCH3_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION

CREBBP EP300

5.63e-0425202M27880
PathwayBIOCARTA_CARM_ER_PATHWAY

CREBBP EP300

6.09e-0426202M2499
PathwayPID_HDAC_CLASSIII_PATHWAY

CREBBP EP300

6.09e-0426202M32
PathwayREACTOME_RESPIRATORY_SYNCYTIAL_VIRUS_INFECTION_PATHWAY

CREBBP EP300 MED8

6.17e-04120203M48233
PathwayREACTOME_ACTIVATION_OF_ANTERIOR_HOX_GENES_IN_HINDBRAIN_DEVELOPMENT_DURING_EARLY_EMBRYOGENESIS

KMT2C CREBBP EP300

6.47e-04122203M29689
PathwayREACTOME_ATTENUATION_PHASE

CREBBP EP300

7.07e-0428202M27254
PathwayPID_RETINOIC_ACID_PATHWAY

CREBBP EP300

8.12e-0430202M207
PathwayREACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION

CREBBP EP300

8.12e-0430202M936
PathwayWP_INITIATION_OF_TRANSCRIPTION_AND_TRANSLATION_ELONGATION_AT_THE_HIV1_LTR

CREBBP EP300

9.25e-0432202M39521
PathwayPID_HIF2PATHWAY

CREBBP EP300

1.04e-0334202M44
PathwayREACTOME_TRANSCRIPTIONAL_REGULATION_BY_NPAS4

REST CREBBP

1.04e-0334202M46422
PathwayREACTOME_SIGNALING_BY_WNT

BCL9L BCL9 CREBBP EP300

1.06e-03330204M7847
PathwayREACTOME_EVASION_BY_RSV_OF_HOST_INTERFERON_RESPONSES

CREBBP EP300

1.11e-0335202M48246
PathwayREACTOME_TRANSCRIPTIONAL_REGULATION_BY_THE_AP_2_TFAP2_FAMILY_OF_TRANSCRIPTION_FACTORS

CREBBP EP300

1.30e-0338202M27757
PathwayREACTOME_HSF1_DEPENDENT_TRANSACTIVATION

CREBBP EP300

1.30e-0338202M27255
PathwayREACTOME_TCF_DEPENDENT_SIGNALING_IN_RESPONSE_TO_WNT

BCL9L BCL9 EP300

1.37e-03158203MM14791
PathwayREACTOME_NGF_STIMULATED_TRANSCRIPTION

REST EP300

1.37e-0339202M29793
PathwayWP_SUDDEN_INFANT_DEATH_SYNDROME_SIDS_SUSCEPTIBILITY_PATHWAYS

REST CREBBP EP300

1.39e-03159203M39373
PathwayPID_FOXM1_PATHWAY

CREBBP EP300

1.44e-0340202M176
PathwayPID_IFNG_PATHWAY

CREBBP EP300

1.44e-0340202M161
PathwayREACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT

CREBBP EP300

1.59e-0342202M17541
PathwayREACTOME_DEACTIVATION_OF_THE_BETA_CATENIN_TRANSACTIVATING_COMPLEX

BCL9L BCL9

1.59e-0342202M27272
PathwayPID_HNF3A_PATHWAY

CREBBP EP300

1.75e-0344202M285
PathwayREACTOME_SUMOYLATION_OF_TRANSCRIPTION_COFACTORS

CREBBP EP300

1.75e-0344202M27295
PathwayKEGG_NOTCH_SIGNALING_PATHWAY

CREBBP EP300

1.99e-0347202M7946
PathwayPID_HES_HEY_PATHWAY

CREBBP EP300

2.07e-0348202M288
PathwayREACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION

CREBBP EP300

2.07e-0348202M611
PathwayREACTOME_RNA_POLYMERASE_II_TRANSCRIPTION

KMT2C REST PABPN1 CNOT1 CREBBP EP300 MED8

2.15e-031387207M734
PathwayREACTOME_TP53_REGULATES_TRANSCRIPTION_OF_CELL_CYCLE_GENES

CNOT1 EP300

2.16e-0349202M27614
PathwayPID_FOXO_PATHWAY

CREBBP EP300

2.16e-0349202M136
PathwayREACTOME_HEME_SIGNALING

CREBBP EP300

2.16e-0349202M41832
PathwayREACTOME_SIGNALING_BY_NOTCH3

CREBBP EP300

2.16e-0349202M618
PathwayBIOCARTA_PPARA_PATHWAY

CREBBP EP300

2.43e-0352202M2404
PathwayPID_NFAT_3PATHWAY

CREBBP EP300

2.52e-0353202M113
PathwayPID_AR_TF_PATHWAY

CREBBP EP300

2.52e-0353202M151
PathwayWP_TGFBETA_SIGNALING_PATHWAY

CREBBP EP300

2.52e-0353202MM15880
PathwayWP_TGFBETA_RECEPTOR_SIGNALING

CREBBP EP300

2.71e-0355202M39351
PathwayREACTOME_TRANSCRIPTIONAL_ACTIVATION_OF_MITOCHONDRIAL_BIOGENESIS

ALAS1 CREBBP

2.71e-0355202M27145
PathwayREACTOME_SIGNALING_BY_NOTCH1_PEST_DOMAIN_MUTANTS_IN_CANCER

CREBBP EP300

3.01e-0358202M29616
PathwayWP_TGFBETA_RECEPTOR_SIGNALING_IN_SKELETAL_DYSPLASIAS

CREBBP EP300

3.12e-0359202M39886
PathwayPID_P53_REGULATION_PATHWAY

CREBBP EP300

3.12e-0359202M261
PathwayWP_SIDS_SUSCEPTIBILITY_PATHWAYS

REST EP300

3.12e-0359202MM15838
PathwayREACTOME_NUCLEAR_EVENTS_KINASE_AND_TRANSCRIPTION_FACTOR_ACTIVATION

REST EP300

3.33e-0361202M152
PathwayREACTOME_CYTOSOLIC_SENSORS_OF_PATHOGEN_ASSOCIATED_DNA

CREBBP EP300

3.66e-0364202M27046
PathwayWP_HISTONE_MODIFICATIONS

KMT2C SETD2

3.77e-0365202M39374
PathwayPID_RB_1PATHWAY

CREBBP EP300

3.77e-0365202M279
PathwayPID_HIF1_TFPATHWAY

CREBBP EP300

3.88e-0366202M255
PathwayPID_HDAC_CLASSI_PATHWAY

CREBBP EP300

3.88e-0366202M101
Pubmed

Identification of cancer/testis-antigen genes by massively parallel signature sequencing.

CT45A6 CT45A10 CT45A7 CT45A5

3.91e-101527415905330
Pubmed

MLL3/MLL4 are required for CBP/p300 binding on enhancers and super-enhancer formation in brown adipogenesis.

KMT2C CREBBP EP300

1.67e-09427328398509
Pubmed

Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation.

BCL9L KMT2C BCL9 CNOT1 CREBBP EP300 PRRC2B

4.57e-0845727732344865
Pubmed

New nomenclature for chromatin-modifying enzymes.

KMT2C SETD2 CREBBP EP300

1.11e-075727418022353
Pubmed

SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.

KMT2C SETD2 CNOT1 CREBBP EP300 PRRC2B MED8

1.59e-0754927738280479
Pubmed

Identification of the hypoxia-inducible factor 2α nuclear interactome in melanoma cells reveals master proteins involved in melanoma development.

CNOT1 CREBBP EP300 MED8

2.01e-076627423275444
Pubmed

Cohesin regulates tissue-specific expression by stabilizing highly occupied cis-regulatory modules.

REST CREBBP EP300

2.32e-071627322780989
Pubmed

Interaction network of human early embryonic transcription factors.

BCL9L KMT2C BCL9 CREBBP EP300 PRRC2B

2.51e-0735127638297188
Pubmed

TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.

GALNT3 BCL9 CNOT1 CREBBP EP300 PRRC2B MED8

4.37e-0763827731182584
Pubmed

Loss of p300 accelerates MDS-associated leukemogenesis.

CREBBP EP300

5.80e-07227227881875
Pubmed

Expression of the nuclear coactivators CBP and p300 in developing craniofacial tissue.

CREBBP EP300

5.80e-07227211963968
Pubmed

Molecular characterization of the histone acetyltransferase CREBBP/EP300 genes in myeloid neoplasia.

CREBBP EP300

5.80e-07227234845315
Pubmed

p300 or CBP is required for insulin-stimulated glucose uptake in skeletal muscle and adipocytes.

CREBBP EP300

5.80e-07227234813504
Pubmed

p300 plays a critical role in maintaining cardiac mitochondrial function and cell survival in postnatal hearts.

CREBBP EP300

5.80e-07227219729597
Pubmed

Endogenous CCAAT/enhancer binding protein beta and p300 are both regulated by growth hormone to mediate transcriptional activation.

CREBBP EP300

5.80e-07227215860545
Pubmed

Differential transcriptional activation by human T-cell leukemia virus type 1 Tax mutants is mediated by distinct interactions with CREB binding protein and p300.

CREBBP EP300

5.80e-0722729528808
Pubmed

Analysis of genetic stability at the EP300 and CREBBP loci in a panel of cancer cell lines.

CREBBP EP300

5.80e-07227212696060
Pubmed

Further delineation of an entity caused by CREBBP and EP300 mutations but not resembling Rubinstein-Taybi syndrome.

CREBBP EP300

5.80e-07227229460469
Pubmed

Rubinstein-Taybi Syndrome

CREBBP EP300

5.80e-07227220301699
Pubmed

Expression of p300 and CBP is associated with poor prognosis in small cell lung cancer.

CREBBP EP300

5.80e-07227224551300
Pubmed

CBP Is Required for Establishing Adaptive Gene Programs in the Adult Mouse Brain.

CREBBP EP300

5.80e-07227236109165
Pubmed

Potential biomarker of metformin action.

CREBBP EP300

5.80e-07227224639469
Pubmed

The histone acetyl transferases CBP and p300 regulate stress response pathways in synovial fibroblasts at transcriptional and functional levels.

CREBBP EP300

5.80e-07227237816914
Pubmed

Retinoids and retinoic acid receptors regulate growth arrest and apoptosis in human mammary epithelial cells and modulate expression of CBP/p300.

CREBBP EP300

5.80e-07227212242694
Pubmed

Genome-wide CRISPR screens reveal synthetic lethal interaction between CREBBP and EP300 in diffuse large B-cell lymphoma.

CREBBP EP300

5.80e-07227233911074
Pubmed

The adenovirus 12 E1A proteins can bind directly to proteins of the p300 transcription co-activator family, including the CREB-binding protein CBP and p300.

CREBBP EP300

5.80e-0722729018065
Pubmed

Coactivators p300 and CBP maintain the identity of mouse embryonic stem cells by mediating long-range chromatin structure.

CREBBP EP300

5.80e-07227224648406
Pubmed

CBP and P300 regulate distinct gene networks required for human primary myoblast differentiation and muscle integrity.

CREBBP EP300

5.80e-07227230135524
Pubmed

Binding of p300/CBP co-activators by polyoma large T antigen.

CREBBP EP300

5.80e-07227211438528
Pubmed

Smad-dependent stimulation of type I collagen gene expression in human skin fibroblasts by TGF-beta involves functional cooperation with p300/CBP transcriptional coactivators.

CREBBP EP300

5.80e-07227210918613
Pubmed

CBP/p300 Drives the Differentiation of Regulatory T Cells through Transcriptional and Non-Transcriptional Mechanisms.

CREBBP EP300

5.80e-07227231182547
Pubmed

Histone Acetyltransferases p300 and CBP Coordinate Distinct Chromatin Remodeling Programs in Vascular Smooth Muscle Plasticity.

CREBBP EP300

5.80e-07227235502657
Pubmed

CREB-binding protein/P300 bromodomain inhibition reduces neutrophil accumulation and activates antitumor immunity in triple-negative breast cancer.

CREBBP EP300

5.80e-07227239287984
Pubmed

Rubinstein-Taybi syndrome in a Saudi boy with distinct features and variants in both the CREBBP and EP300 genes: a case report.

CREBBP EP300

5.80e-07227230635043
Pubmed

p300 and cAMP response element-binding protein-binding protein in skeletal muscle homeostasis, contractile function, and survival.

CREBBP EP300

5.80e-07227231898871
Pubmed

Distribution of co-activators CBP and p300 during mouse oocyte and embryo development.

CREBBP EP300

5.80e-07227216596650
Pubmed

Phenotype and genotype in 52 patients with Rubinstein-Taybi syndrome caused by EP300 mutations.

CREBBP EP300

5.80e-07227227648933
Pubmed

Germline or inducible knockout of p300 or CBP in skeletal muscle does not alter insulin sensitivity.

CREBBP EP300

5.80e-07227230888860
Pubmed

Exploitation of EP300 and CREBBP Lysine Acetyltransferases by Cancer.

CREBBP EP300

5.80e-07227227881443
Pubmed

The p300 and CBP Transcriptional Coactivators Are Required for β-Cell and α-Cell Proliferation.

CREBBP EP300

5.80e-07227229217654
Pubmed

Spatiotemporal expression of histone acetyltransferases, p300 and CBP, in developing embryonic hearts.

CREBBP EP300

5.80e-07227219272189
Pubmed

Developmentally regulated expression of the transcriptional cofactors/histone acetyltransferases CBP and p300 during mouse embryogenesis.

CREBBP EP300

5.80e-07227210610021
Pubmed

Bcl9/Bcl9l are critical for Wnt-mediated regulation of stem cell traits in colon epithelium and adenocarcinomas.

BCL9L BCL9

5.80e-07227220682801
Pubmed

Emerging roles of p300/CBP in autophagy and autophagy-related human disorders.

CREBBP EP300

5.80e-07227237314181
Pubmed

Exon deletions of the EP300 and CREBBP genes in two children with Rubinstein-Taybi syndrome detected by aCGH.

CREBBP EP300

5.80e-07227220717166
Pubmed

Distinct roles for CREB-binding protein and p300 in hematopoietic stem cell self-renewal.

CREBBP EP300

5.80e-07227212397173
Pubmed

Differences in the interactions of oncogenic adenovirus 12 early region 1A and nononcogenic adenovirus 2 early region 1A with the cellular coactivators p300 and CBP.

CREBBP EP300

5.80e-07227210049825
Pubmed

CBP/p300 TAZ1 domain forms a structured scaffold for ligand binding.

CREBBP EP300

5.80e-07227215641773
Pubmed

Targeting BCL9/BCL9L enhances antigen presentation by promoting conventional type 1 dendritic cell (cDC1) activation and tumor infiltration.

BCL9L BCL9

5.80e-07227238811552
Pubmed

Differential contribution of p300 and CBP to regulatory element acetylation in mESCs.

CREBBP EP300

5.80e-07227232690000
Pubmed

Interaction of human immunodeficiency virus type 1 Tat with the transcriptional coactivators p300 and CREB binding protein.

CREBBP EP300

5.80e-0722729733868
Pubmed

CBP/p300 antagonises EGFR-Ras-Erk signalling and suppresses increased Ras-Erk signalling-induced tumour formation in mice.

CREBBP EP300

5.80e-07227230953353
Pubmed

Disrupting the CH1 domain structure in the acetyltransferases CBP and p300 results in lean mice with increased metabolic control.

CREBBP EP300

5.80e-07227221803292
Pubmed

BCL9/BCL9L promotes tumorigenicity through immune-dependent and independent mechanisms in triple negative breast cancer.

BCL9L BCL9

5.80e-07227233767438
Pubmed

HIV-1 tat transactivator recruits p300 and CREB-binding protein histone acetyltransferases to the viral promoter.

CREBBP EP300

5.80e-0722729811832
Pubmed

CBP/p300 acetyltransferase activity in hematologic malignancies.

CREBBP EP300

5.80e-07227227380996
Pubmed

CREBBP and p300 lysine acetyl transferases in the DNA damage response.

CREBBP EP300

5.80e-07227229170789
Pubmed

Two independent regions of simian virus 40 T antigen increase CBP/p300 levels, alter patterns of cellular histone acetylation, and immortalize primary cells.

CREBBP EP300

5.80e-07227224089570
Pubmed

The epigenetic regulators CBP and p300 facilitate leukemogenesis and represent therapeutic targets in acute myeloid leukemia.

CREBBP EP300

5.80e-07227225893291
Pubmed

Human T-lymphotropic virus type 1 p30(II) regulates gene transcription by binding CREB binding protein/p300.

CREBBP EP300

5.80e-07227211559821
Pubmed

Crebbp haploinsufficiency in mice alters the bone marrow microenvironment, leading to loss of stem cells and excessive myelopoiesis.

CREBBP EP300

5.80e-07227221555743
Pubmed

Rubinstein-Taybi syndrome in Chinese population with four novel mutations.

CREBBP EP300

5.80e-07227233063428
Pubmed

CBP/p300 induction is required for retinoic acid sensitivity in human mammary cells.

CREBBP EP300

5.80e-07227212646247
Pubmed

EP300/CBP is crucial for cAMP-PKA pathway to alleviate podocyte dedifferentiation via targeting Notch3 signaling.

CREBBP EP300

5.80e-07227234506759
Pubmed

Lack of somatic mutations in the catalytic domains of CREBBP and EP300 genes implies a role for histone deacetylase inhibition in myeloproliferative neoplasms.

CREBBP EP300

5.80e-07227222177454
Pubmed

Essential role of BCL9-2 in the switch between beta-catenin's adhesive and transcriptional functions.

BCL9L BCL9

5.80e-07227215371335
Pubmed

Genetic heterogeneity in Rubinstein-Taybi syndrome: mutations in both the CBP and EP300 genes cause disease.

CREBBP EP300

5.80e-07227215706485
Pubmed

CARM1 inhibition reduces histone acetyltransferase activity causing synthetic lethality in CREBBP/EP300-mutated lymphomas.

CREBBP EP300

5.80e-07227232576962
Pubmed

Syndromic features and mild cognitive impairment in mice with genetic reduction on p300 activity: Differential contribution of p300 and CBP to Rubinstein-Taybi syndrome etiology.

CREBBP EP300

5.80e-07227219822209
Pubmed

AR coactivators, CBP/p300, are critical mediators of DNA repair in prostate cancer.

CREBBP EP300

5.80e-07227239266679
Pubmed

A specific CBP/p300-dependent gene expression programme drives the metabolic remodelling in late stages of spermatogenesis.

CREBBP EP300

5.80e-07227224522976
Pubmed

A boy with classical Rubinstein-Taybi syndrome but no detectable mutation in the CREBBP and EP300 genes.

CREBBP EP300

5.80e-07227222303793
Pubmed

Histone acetyltransferase activities of cAMP-regulated enhancer-binding protein and p300 in tissues of fetal, young, and old mice.

CREBBP EP300

5.80e-07227211867645
Pubmed

CBP is required for environmental enrichment-induced neurogenesis and cognitive enhancement.

CREBBP EP300

5.80e-07227221847097
Pubmed

Inhibition of histone acetyltransferase function radiosensitizes CREBBP/EP300 mutants via repression of homologous recombination, potentially targeting a gain of function.

CREBBP EP300

5.80e-07227234732714
Pubmed

Targeting histone acetylation dynamics and oncogenic transcription by catalytic P300/CBP inhibition.

CREBBP EP300

5.80e-07227234019788
Pubmed

Inhibitory effect of AP-1 complex on 5-aminolevulinate synthase gene expression through sequestration of cAMP-response element protein (CRE)-binding protein (CBP) coactivator.

ALAS1 CREBBP

5.80e-07227212433930
Pubmed

Composite co-activator ARC mediates chromatin-directed transcriptional activation.

CREBBP EP300 MED8

7.31e-072327310235267
Pubmed

Proteomic Analysis of the EWS-Fli-1 Interactome Reveals the Role of the Lysosome in EWS-Fli-1 Turnover.

BCL9L BCL9 PABPN1 CREBBP EP300 MED8

7.66e-0742527624999758
Pubmed

Human transcription factor protein interaction networks.

BCL9L KMT2C BCL9 PABPN1 CNOT1 CREBBP EP300 PRRC2B MED8

7.80e-07142927935140242
Pubmed

DDB1 binds histone reader BRWD3 to activate the transcriptional cascade in adipogenesis and promote onset of obesity.

SETD2 CREBBP EP300 MED8

1.03e-069927434161765
Pubmed

Transcriptional coactivators CBP and p300 cooperatively enhance HNF-1alpha-mediated expression of the albumin gene in hepatocytes.

CREBBP EP300

1.74e-06327215598887
Pubmed

Dendrite development regulated by CREST, a calcium-regulated transcriptional activator.

CREBBP EP300

1.74e-06327214716005
Pubmed

The acetate/ACSS2 switch regulates HIF-2 stress signaling in the tumor cell microenvironment.

CREBBP EP300

1.74e-06327225689462
Pubmed

The human T-cell leukemia virus type 1 tax protein confers CBP/p300 recruitment and transcriptional activation properties to phosphorylated CREB.

CREBBP EP300

1.74e-06327218070920
Pubmed

Acetylation of beta-catenin by CREB-binding protein (CBP).

CREBBP EP300

1.74e-06327211973335
Pubmed

The acetylation of transcription factor HBP1 by p300/CBP enhances p16INK4A expression.

CREBBP EP300

1.74e-06327221967847
Pubmed

Synergistic activation of transcription by CBP and p53.

CREBBP EP300

1.74e-0632729194564
Pubmed

Regulation of NF-kappaB action by reversible acetylation.

CREBBP EP300

1.74e-06327215171256
Pubmed

p300/CBP acts as a coactivator of the cone-rod homeobox transcription factor.

CREBBP EP300

1.74e-06327210708567
Pubmed

Conditional knockout mice reveal distinct functions for the global transcriptional coactivators CBP and p300 in T-cell development.

CREBBP EP300

1.74e-06327216428436
Pubmed

Histone acetyl transferases CBP and p300 are necessary for maintenance of renin cell identity and transformation of smooth muscle cells to the renin phenotype.

CREBBP EP300

1.74e-06327222523253
Pubmed

Mutual synergistic folding in recruitment of CBP/p300 by p160 nuclear receptor coactivators.

CREBBP EP300

1.74e-06327211823864
Pubmed

CBP and p300 are essential for renin cell identity and morphological integrity of the kidney.

CREBBP EP300

1.74e-06327219252086
Pubmed

An essential role for p300/CBP in the cellular response to hypoxia.

CREBBP EP300

1.74e-0632728917528
Pubmed

Histone acetyltransferase p300 is a coactivator for transcription factor REL and is C-terminally truncated in the human diffuse large B-cell lymphoma cell line RC-K8.

CREBBP EP300

1.74e-06327219948376
Pubmed

E2A and CBP/p300 act in synergy to promote chromatin accessibility of the immunoglobulin κ locus.

CREBBP EP300

1.74e-06327222544934
Pubmed

Whole-transcriptome sequencing identifies a distinct subtype of acute lymphoblastic leukemia with predominant genomic abnormalities of EP300 and CREBBP.

CREBBP EP300

1.74e-06327227903646
Pubmed

Gene dose-dependent control of hematopoiesis and hematologic tumor suppression by CBP.

CREBBP EP300

1.74e-06327210673499
Pubmed

Inhibition of p300/CBP by early B-cell factor.

CREBBP EP300

1.74e-06327212748286
InteractionGCM1 interactions

KMT2C BCL9 CREBBP EP300 PRRC2B

2.34e-0868265int:GCM1
InteractionEGR2 interactions

BCL9L KMT2C BCL9 CREBBP EP300 PRRC2B

6.84e-08171266int:EGR2
InteractionGSC interactions

BCL9L KMT2C BCL9 CREBBP EP300

8.17e-0887265int:GSC
InteractionMYOD1 interactions

KMT2C BCL9 PABPN1 CREBBP EP300 MED8

1.44e-07194266int:MYOD1
InteractionPAX8 interactions

KMT2C BCL9 CREBBP EP300 PRRC2B

2.78e-07111265int:PAX8
InteractionERG interactions

KMT2C PTPRD BCL9 CREBBP EP300 PRRC2B

3.28e-07223266int:ERG
InteractionTBXT interactions

KMT2C BCL9 CREBBP EP300 MED8

3.46e-07116265int:TBXT
InteractionCRX interactions

BCL9L KMT2C BCL9 CREBBP EP300 PRRC2B

7.04e-07254266int:CRX
InteractionNUP35 interactions

BCL9L KMT2C BCL9 CNOT1 CREBBP EP300 PRRC2B

8.08e-07424267int:NUP35
InteractionSP7 interactions

BCL9L KMT2C BCL9 CREBBP EP300 PRRC2B

2.00e-06304266int:SP7
InteractionHNF1B interactions

KMT2C BCL9 CREBBP EP300 PRRC2B

3.96e-06190265int:HNF1B
InteractionKLF5 interactions

KMT2C BCL9 CREBBP EP300 PRRC2B

4.49e-06195265int:KLF5
InteractionGATA2 interactions

KMT2C BCL9 CREBBP EP300 PRRC2B

4.96e-06199265int:GATA2
InteractionFEV interactions

KMT2C BCL9 CREBBP EP300 PRRC2B

5.47e-06203265int:FEV
InteractionFOXI1 interactions

KMT2C BCL9 CREBBP EP300

5.63e-0692264int:FOXI1
InteractionSOX9 interactions

KMT2C BCL9 CREBBP EP300

6.95e-0697264int:SOX9
InteractionTBR1 interactions

BCL9L KMT2C BCL9 EP300

1.27e-05113264int:TBR1
InteractionPAX7 interactions

KMT2C BCL9 CREBBP EP300

1.84e-05124264int:PAX7
InteractionPAX9 interactions

BCL9L KMT2C BCL9 EP300

2.21e-05130264int:PAX9
InteractionCXXC1 interactions

KMT2C EP300 CT45A5 MED8

2.35e-05132264int:CXXC1
InteractionAR interactions

BCL9L KMT2C BCL9 TNS1 CREBBP EP300 PRRC2B MED8

2.37e-05992268int:AR
InteractionKLF15 interactions

KMT2C BCL9 CREBBP EP300 PRRC2B

3.06e-05290265int:KLF15
InteractionPYGO2 interactions

BCL9L BCL9 CREBBP

3.17e-0548263int:PYGO2
InteractionFOS interactions

KMT2C BCL9 CREBBP EP300 MED8

4.34e-05312265int:FOS
InteractionSOX2 interactions

NAV2 BCL9L KMT2C SETD2 BCL9 PABPN1 CNOT1 EP300 PRRC2B

4.39e-051422269int:SOX2
InteractionKLF4 interactions

KMT2C BCL9 CREBBP EP300

4.99e-05160264int:KLF4
InteractionHOXB3 interactions

CREBBP EP300

5.73e-059262int:HOXB3
InteractionARGFX interactions

CREBBP EP300

5.73e-059262int:ARGFX
InteractionSSBP4 interactions

BCL9L BCL9 EP300

5.91e-0559263int:SSBP4
InteractionSETD1A interactions

KMT2C CREBBP EP300 CT45A5

6.32e-05170264int:SETD1A
InteractionEPAS1 interactions

CNOT1 CREBBP EP300 MED8

6.77e-05173264int:EPAS1
InteractionTLX1 interactions

KMT2C BCL9 CREBBP EP300

7.07e-05175264int:TLX1
InteractionGATA3 interactions

BCL9 CREBBP EP300 PRRC2B

9.15e-05187264int:GATA3
InteractionPAX6 interactions

KMT2C BCL9 CREBBP EP300 PRRC2B

9.24e-05366265int:PAX6
InteractionETV4 interactions

BCL9 CREBBP EP300

9.44e-0569263int:ETV4
InteractionTLE3 interactions

BCL9L SETD2 BCL9 CREBBP EP300

1.05e-04376265int:TLE3
InteractionEWSR1 interactions

BCL9L REST BCL9 PABPN1 CREBBP EP300 MED8

1.13e-04906267int:EWSR1
InteractionMEX3A interactions

BCL9L CNOT1 CREBBP EP300 PRRC2B

1.16e-04384265int:MEX3A
InteractionGPBP1 interactions

CNOT1 CREBBP EP300

1.21e-0475263int:GPBP1
InteractionASCL2 interactions

KMT2C EP300

1.24e-0413262int:ASCL2
InteractionHNF1A interactions

KMT2C CREBBP EP300

1.47e-0480263int:HNF1A
InteractionSOX7 interactions

KMT2C CREBBP EP300

1.58e-0482263int:SOX7
InteractionKLF2 interactions

CREBBP EP300

1.66e-0415262int:KLF2
InteractionPSD2 interactions

SETD2 EP300

1.66e-0415262int:PSD2
InteractionSP3 interactions

REST CREBBP EP300

1.69e-0484263int:SP3
InteractionIRF4 interactions

KMT2C EP300 PRRC2B

1.76e-0485263int:IRF4
InteractionNR3C1 interactions

GALNT3 BCL9 CNOT1 CREBBP EP300 PRRC2B MED8

1.77e-04974267int:NR3C1
InteractionWWTR1 interactions

SETD2 CNOT1 CREBBP EP300 PRRC2B

1.80e-04422265int:WWTR1
InteractionCDX2 interactions

SETD2 CREBBP EP300

1.82e-0486263int:CDX2
InteractionPPP1R13L interactions

CREBBP EP300 PRRC2B

1.95e-0488263int:PPP1R13L
InteractionMAML2 interactions

CREBBP EP300

2.15e-0417262int:MAML2
InteractionPABPC1 interactions

KMT2C REST PABPN1 CNOT1 EP300 PRRC2B

2.17e-04699266int:PABPC1
InteractionRERE interactions

REST EP300 PRRC2B

2.29e-0493263int:RERE
InteractionEYA4 interactions

BCL9 CREBBP EP300 PRRC2B

2.50e-04243264int:EYA4
InteractionGLI3 interactions

CNOT1 CREBBP PRRC2B

2.67e-0498263int:GLI3
InteractionNEUROG1 interactions

CREBBP EP300

2.70e-0419262int:NEUROG1
InteractionSPIB interactions

CREBBP EP300

3.00e-0420262int:SPIB
InteractionSSBP2 interactions

BCL9L BCL9 EP300

3.27e-04105263int:SSBP2
InteractionCITED4 interactions

CREBBP EP300

3.31e-0421262int:CITED4
InteractionHOXB4 interactions

CREBBP EP300

3.31e-0421262int:HOXB4
InteractionPLAGL1 interactions

CREBBP EP300

3.31e-0421262int:PLAGL1
InteractionKLF13 interactions

CREBBP EP300

3.31e-0421262int:KLF13
InteractionYAP1 interactions

BCL9L KMT2C SETD2 CNOT1 CREBBP EP300 MED8

3.62e-041095267int:YAP1
InteractionTOP3B interactions

NAV2 KMT2C TMCO6 BCL9 PABPN1 CNOT1 EP300 PRRC2B

3.74e-041470268int:TOP3B
InteractionCITED2 interactions

CREBBP EP300

3.98e-0423262int:CITED2
InteractionHOXD10 interactions

CREBBP EP300

3.98e-0423262int:HOXD10
InteractionHNF4A interactions

KMT2C CREBBP EP300 MED8

4.00e-04275264int:HNF4A
InteractionLDB1 interactions

BCL9L BCL9 EP300

4.28e-04115263int:LDB1
InteractionTBX21 interactions

CREBBP EP300

4.34e-0424262int:TBX21
InteractionCNTN2 interactions

CREBBP EP300

4.34e-0424262int:CNTN2
InteractionNR6A1 interactions

CREBBP EP300

4.34e-0424262int:NR6A1
InteractionALX1 interactions

CREBBP EP300

4.71e-0425262int:ALX1
InteractionTLX3 interactions

BCL9L KMT2C BCL9 EP300

4.95e-04291264int:TLX3
InteractionHOXB7 interactions

CREBBP EP300

5.10e-0426262int:HOXB7
InteractionPOLR2A interactions

SETD2 CNOT1 CREBBP EP300 MED8

5.41e-04536265int:POLR2A
InteractionFMR1 interactions

BCL9 TNS1 CNOT1 PRRC2B IQSEC2

5.41e-04536265int:FMR1
InteractionVDR interactions

SETD2 CREBBP EP300

5.72e-04127263int:VDR
InteractionPYGO1 interactions

BCL9L BCL9

5.93e-0428262int:PYGO1
InteractionFHL1 interactions

REST CREBBP EP300

5.98e-04129263int:FHL1
InteractionPPARG interactions

KMT2C CNOT1 CREBBP EP300

6.06e-04307264int:PPARG
InteractionKCNC3 interactions

PTPRD TNS1

6.36e-0429262int:KCNC3
InteractionHOXD4 interactions

CREBBP EP300

6.81e-0430262int:HOXD4
InteractionSMG7 interactions

BCL9 CNOT1 CREBBP PRRC2B

6.99e-04319264int:SMG7
InteractionLRRTM4 interactions

SETD2 NRXN3

7.27e-0431262int:LRRTM4
InteractionIZUMO1 interactions

PTPRD CNOT1

7.27e-0431262int:IZUMO1
InteractionCRTC1 interactions

CREBBP EP300

7.27e-0431262int:CRTC1
InteractionGTF2B interactions

REST CREBBP EP300

7.75e-04141263int:GTF2B
InteractionNEUROD1 interactions

CREBBP EP300

7.75e-0432262int:NEUROD1
InteractionCEBPA interactions

KMT2C BCL9 CNOT1 CREBBP EP300 PRRC2B MED8

7.85e-041245267int:CEBPA
InteractionTLX2 interactions

KMT2C BCL9 PABPN1

7.91e-04142263int:TLX2
InteractionNFIB interactions

KMT2C BCL9 CREBBP

7.91e-04142263int:NFIB
InteractionRPS6KA5 interactions

CNOT1 CREBBP EP300

8.23e-04144263int:RPS6KA5
InteractionTRERF1 interactions

CREBBP EP300

8.25e-0433262int:TRERF1
InteractionNCOA6 interactions

KMT2C CREBBP EP300

8.40e-04145263int:NCOA6
InteractionC3orf62 interactions

CREBBP EP300

9.28e-0435262int:C3orf62
InteractionHSF1 interactions

BCL9L PABPN1 CREBBP EP300 PRRC2B

9.63e-04609265int:HSF1
InteractionE2F5 interactions

CREBBP EP300

9.81e-0436262int:E2F5
InteractionHOXB2 interactions

CREBBP EP300

9.81e-0436262int:HOXB2
InteractionCITED1 interactions

CREBBP EP300

1.04e-0337262int:CITED1
InteractionKLF1 interactions

CREBBP EP300

1.04e-0337262int:KLF1
CytobandEnsembl 112 genes in cytogenetic band chrXq26

CT45A6 CT45A10 CT45A7 CT45A5

3.05e-06171274chrXq26
CytobandXq26.3

CT45A6 CT45A5

7.19e-0467272Xq26.3
CytobandEnsembl 112 genes in cytogenetic band chr14q24

NRXN3 ADAM20

6.17e-03200272chr14q24
GeneFamilyZinc fingers ZZ-type|Lysine acetyltransferases

CREBBP EP300

7.52e-0517142486
GeneFamilyZinc fingers ZZ-type|Lysine acetyltransferases

CREBBP EP300

8.46e-051814291
GeneFamilyZinc fingers C2H2-type|Lysine methyltransferases|PR/SET domain family

KMT2C SETD2

3.08e-0434142487
CoexpressionHE_LIM_SUN_FETAL_LUNG_C0_MYOFIBROBLAST_1_CELL

CT45A6 CT45A10 CT45A7 CT45A5

7.37e-0769274M45681
CoexpressionHE_LIM_SUN_FETAL_LUNG_C0_MYOFIBROBLAST_2_CELL

CT45A6 CT45A10 CT45A7 CT45A5

3.83e-06104274M45682
CoexpressionSCHAEFFER_PROSTATE_DEVELOPMENT_6HR_DN

KMT2C REST PTPRD BCL9 PABPN1 CREBBP

6.67e-06467276M1347
CoexpressionSCHAEFFER_PROSTATE_DEVELOPMENT_6HR_DN

KMT2C REST PTPRD BCL9 PABPN1 CREBBP

8.18e-06484276MM999
CoexpressionIWANAGA_CARCINOGENESIS_BY_KRAS_UP

BCL9L NRXN3 GALNT3 CREBBP

3.12e-05177274M9118
CoexpressionGSE27241_WT_VS_RORGT_KO_TH17_POLARIZED_CD4_TCELL_TREATED_WITH_DIGOXIN_UP

KMT2C SETD2 CREBBP EP300

3.34e-05180274M8239
CoexpressionIWANAGA_CARCINOGENESIS_BY_KRAS_UP

BCL9L NRXN3 GALNT3 CREBBP

4.29e-05192274MM752
ToppCellPND01-03-samps-Mesenchymal-Matrix_fibroblast-MatrixFB-A|PND01-03-samps / Age Group, Lineage, Cell class and subclass

NAV2 DGKB PTPRD TNS1

5.12e-06191274e7c605b56934d1383237c1f946dbccef25d91368
ToppCellPND01-03-samps-Mesenchymal-Matrix_fibroblast|PND01-03-samps / Age Group, Lineage, Cell class and subclass

NAV2 DGKB PTPRD TNS1

5.67e-0619627454f4cf778f95a9ff662e5c7520916a25e605bf95
ToppCellLPS_anti-TNF-Epithelial_alveolar-AT_2-Differentiating_AT2|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

NAV2 ALAS1 NRXN3 GALNT3

5.78e-061972741485933986921ff45669d9b7501c8d17050b3e97
ToppCellLPS_IL1RA-Epithelial_alveolar-AT_2-Differentiating_AT2|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

NAV2 ALAS1 NRXN3 GALNT3

5.90e-06198274285f729140b1df029c24f6ca1d2438470ac51794
ToppCellLPS_IL1RA_TNF-Epithelial_alveolar-AT_2|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

NAV2 ALAS1 NRXN3 GALNT3

5.90e-06198274aa80315395cb5dffc25927c8a77cd2037aea8772
ToppCellLPS_IL1RA-Epithelial_alveolar|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

NAV2 ALAS1 NRXN3 GALNT3

6.02e-061992745b140ac88ebc25ce397ae577e48f3e271faf46e7
ToppCellE15.5-Mesenchymal-developing_mesenchymal_cell-mesenchymal_immature_unknown_1|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

DGKB TNS1 FMN1

1.08e-04154273e65e4636646164610f33f7bbac0d879a3ea55986
ToppCellwk_15-18-Mesenchymal-Myofibro_&_SMC-Myofibro_2|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

CT45A6 CT45A10 CT45A5

1.15e-04157273b9d04ee417c0d8ea0801d10f1c54e138587009fd
ToppCellCOVID-19-kidney-Technical/muscle_(Mes)|kidney / Disease (COVID-19 only), tissue and cell type

DGKB DNAH3 NRXN3

1.19e-041592735335cbcdeaf2bbd0268bbfe0e45c8c0d288e640d
ToppCellP07-Mesenchymal-developing_mesenchymal_cell-mesenchymal_immature_unknown_1|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

NAV2 PTPRD TNS1

1.24e-04161273b19f82dd98a3064581793711bb70373f18abecd9
ToppCellwk_08-11-Mesenchymal-Myofibro_&_SMC-Myofibro_2|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

CT45A6 CT45A10 CT45A5

1.45e-04170273fefb07a7e308b620f946b9ff2b01e1796446fe38
ToppCellChildren_(3_yrs)-Epithelial-club_cell-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

NAV2 NRXN3 PTPRD

1.72e-04180273b509c7d6bdfba672065fb722874bdc68de72ba1c
ToppCellLPS-antiTNF-Epithelial_alveolar-AT_2|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

NAV2 NRXN3 FMN1

1.72e-04180273b798a3fa2dd15b68aa4267f665559527043dcc07
ToppCellLPS-IL1RA+antiTNF-Epithelial_alveolar-AT_2|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

NAV2 NRXN3 FMN1

1.77e-0418227317ed11a7ea366dd3106400511d5e628d3f1a9c3e
ToppCellLPS-antiTNF-Epithelial_alveolar-AT_2-Differentiating_AT2|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

NAV2 NRXN3 FMN1

1.83e-04184273ab2f06906fc7a9931dfa0864ef506832b07fb93e
ToppCellCOVID-19-Epithelial_cells-Airway_club|COVID-19 / group, cell type (main and fine annotations)

NAV2 NRXN3 PTPRD

1.86e-04185273cfe6fd73d817e173fe803bc1683c291d9bcb8608
ToppCellP03|World / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

NAV2 PTPRD TNS1

1.86e-04185273a07dbe1f76e40734a28826423a5cc64b8e56af5e
ToppCellLPS-IL1RA+antiTNF-Epithelial_alveolar-AT_2-Differentiating_AT2|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

NAV2 NRXN3 FMN1

1.89e-04186273e83718fabb057100835d3357df407f283d23fe16
ToppCell10x_5'_v1-Non-neoplastic-Myeloid-Mono-Mono_anti-infl-Z|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

PTPRD TNS1 FMN1

1.89e-04186273f73cb91e74a806858650ae97f543fc779ba4cff8
ToppCell10x_5'_v1-Non-neoplastic-Myeloid-Mono-Mono_anti-infl|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

PTPRD TNS1 FMN1

1.89e-041862738694ca16c9780729f4fba67ba20e35745f1eb4e9
ToppCellLPS-antiTNF-Epithelial_alveolar|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

NAV2 NRXN3 FMN1

1.92e-04187273201ff693e4756ee3e44762885b3a303a77eb535b
ToppCellpdx-Tumor_cells-T5|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

NAV2 NRXN3 FMN1

1.92e-041872737e376831a11ee72ed87abcdac631ca46ae29c250
ToppCellLPS-IL1RA-Epithelial_alveolar-AT_2-Differentiating_AT2|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

NAV2 NRXN3 FMN1

1.95e-041882734bdf8d49af0e9da349b16e3f012e1b0eec04cc4f
ToppCellLPS-IL1RA-Epithelial_alveolar|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

NAV2 NRXN3 FMN1

1.95e-041882736164d467b612767ceba15de34176bcc8e8c36ab8
ToppCellPND07-28-samps-Mesenchymal-Matrix_fibroblast|PND07-28-samps / Age Group, Lineage, Cell class and subclass

NAV2 PTPRD TNS1

1.98e-04189273dc5164591dea45b420798b94dda211be03daa70c
ToppCellwk_15-18-Mesenchymal-Myofibro_&_SMC-Myofibro_1|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

CT45A6 CT45A10 CT45A5

2.01e-04190273d24af6af3271e34afab744352afd28be8a7cc5c3
ToppCellwk_08-11-Mesenchymal-Myofibro_&_SMC-Myofibro_1|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

CT45A6 CT45A10 CT45A5

2.01e-0419027371a00f63fdd4eb4cc6f190d37e7a0417cdaafacb
ToppCellPND07-28-samps-Mesenchymal-Matrix_fibroblast-FB-3|PND07-28-samps / Age Group, Lineage, Cell class and subclass

NAV2 PTPRD TNS1

2.01e-041902731196b8ea2c44c7c80f5ee589dd517e6a413f2077
ToppCellPND14-Mesenchymal-Mesenchymal_structural|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NAV2 PTPRD TNS1

2.08e-0419227325492568f9cbe097b7bb1db50d8b817c80ea87d7
ToppCellP03-Mesenchymal-mesenchymal_fibroblast-alveolar_fibroblast_Wnt2-pa|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

NAV2 PTPRD TNS1

2.08e-041922732802fae55683345ff94a1ecf73b6fbee4f17481e
ToppCellP07-Mesenchymal-mesenchymal_fibroblast-alveolar_fibroblast_Wnt2-pa|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

NAV2 PTPRD TNS1

2.08e-041922730afb9dbe468e0be442c326e11c5fc0f699b32f23
ToppCellPND14-Mesenchymal-Mesenchymal_structural-Fibroblastic|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NAV2 PTPRD TNS1

2.08e-04192273de9c1536d5aee86f9c62acbc54ca8fa581c00f17
ToppCellEpithelial-club_cell|World / Lineage, Cell type, age group and donor

NAV2 NRXN3 PTPRD

2.11e-041932732bdd09004fa433550958ec42ba4b06271a4aaf7c
ToppCellcritical-Lymphoid-NK|Lymphoid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

NAV2 TNS1 FMN1

2.11e-041932736be11fef87af04ee7a3cc223882ccd4077caded9
ToppCellwk_20-22-Mesenchymal-Myofibro_&_SMC-Myofibro_2|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

CT45A6 CT45A10 CT45A5

2.11e-041932732f203f6f0c2135acb046c9351a633c3b5b254a46
ToppCellPND01-03-samps-Mesenchymal|PND01-03-samps / Age Group, Lineage, Cell class and subclass

DGKB PTPRD TNS1

2.14e-041942734f9bd0ded0dde1df885850714f29e73e992539a5
ToppCellPND14-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_mature|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NAV2 PTPRD TNS1

2.17e-041952732b8ee7990267bb52b7e6ae03f509ffebf8908122
ToppCellPND14-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NAV2 PTPRD TNS1

2.17e-041952733a0cad69cfc150a27a0666f612f5294c817197d7
ToppCellPND03-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

DGKB PTPRD TNS1

2.20e-041962732a885eed52f9b002c7995e11e450c7e8d7ae69e6
ToppCellPND03-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_mature|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

DGKB PTPRD TNS1

2.20e-0419627314246f00c90741a5f8683f377e22e3a7c99661b9
ToppCellControl_saline-Epithelial_alveolar-AT_2-Differentiating_AT2|Control_saline / Treatment groups by lineage, cell group, cell type

NAV2 NRXN3 GALNT3

2.24e-0419727344a59dfb889577b3160a5b13ada1276771a00241
ToppCellTracheal-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_pulmonary|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

NAV2 DGKB TNS1

2.24e-04197273ac4f53acb2f8a428b0f2fab3c30a34e095a1bed7
ToppCellLPS_anti-TNF-Epithelial_alveolar-AT_2|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

NAV2 ALAS1 GALNT3

2.24e-041972731638959d7aecb9fc5285eb7e4a3103ca437989e2
ToppCellParenchymal-NucSeq|Parenchymal / Cell types per location group and 10X technology with lineage, and cell group designations

NAV2 PTPRD FMN1

2.27e-041982731996373bdccc55aac347d349bd22f6aad6d0c668
ToppCellLPS_IL1RA-Epithelial_alveolar-AT_2|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

NAV2 ALAS1 GALNT3

2.27e-04198273c4e7512f0e1d115f2be8acae6048eda8b6b640b2
ToppCellLPS_anti-TNF-Epithelial_alveolar|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

NAV2 ALAS1 NRXN3

2.27e-0419827353e9ed1b19cb26be58da0f37057caca0cdfaabeb
ToppCellTracheal-10x5prime-Stromal-Myofibroblastic-Muscle_smooth_airway_ASM|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

DGKB NRXN3 TNS1

2.27e-041982731e1ea54f0c234f3b6d29064c4881d8a0c0949a75
ToppCellFetal_29-31_weeks-Epithelial-club_cell|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

NAV2 NRXN3 PTPRD

2.27e-041982735fc25b008a4d8d6bec83923a16f64dd9e1ff1f2d
ToppCellLPS_IL1RA_TNF-Epithelial_alveolar-AT_1-Differentiating_AT2|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

NAV2 NRXN3 IQSEC2

2.31e-04199273121de4e02585de3a3010398387c523bacf8ce546
ToppCellMacroglial-Oligodendrocytes|Macroglial / cells hierarchy compared to all cells using T-Statistic

NRXN3 PTPRD FMN1

2.34e-042002734dbac2f2587e87ca5a0622f50439bb5447e93c7f
ToppCellLPS_IL1RA_TNF-Epithelial_alveolar-AT_2-Differentiating_AT2|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

NAV2 NRXN3 GALNT3

2.34e-04200273e8db082aa4d0597500e4f16a5c0ea3e62c6c59ae
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW10-Neuronal-Cortical_neuron|GW10 / Sample Type, Dataset, Time_group, and Cell type.

BCL9L ALAS1 PTPRD

2.34e-04200273458fb0f40c1720f1cacedf78c40bd059692bfc62
ToppCellLPS_IL1RA_TNF-Epithelial_alveolar|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

NAV2 NRXN3 GALNT3

2.34e-04200273c89f3cb36bb14c476d6a392bfd3ded1c8feecfeb
ToppCellMacroglial-Oligodendrocytes-OPALIN----L1-6|Macroglial / cells hierarchy compared to all cells using T-Statistic

NRXN3 PTPRD FMN1

2.34e-04200273272909f4354f3ae22e2b2f8f35970e6b0e92cfe2
ToppCellMacroglial-Oligodendrocytes-OPALIN--|Macroglial / cells hierarchy compared to all cells using T-Statistic

NRXN3 PTPRD FMN1

2.34e-0420027326b989e30bbbaf30904ced03f6aae3dea25c732c
ToppCellMS-IIF|MS / Disease, condition lineage and cell class

TNS1 CNOT1 FMN1

2.34e-04200273221f59edcfc18baece13184c2552d26022228146
ToppCellMacroglial-Oligodendrocytes-OPALIN---|Macroglial / cells hierarchy compared to all cells using T-Statistic

NRXN3 PTPRD FMN1

2.34e-042002731314664c1721e9ecb1e2c3482a039044b0fe50a9
ToppCellMacroglial-Oligodendrocytes-OPALIN|Macroglial / cells hierarchy compared to all cells using T-Statistic

NRXN3 PTPRD FMN1

2.34e-042002735f75a9b8bcd49d9bbb1e9ce2de730eaec96369ca
ToppCellLPS_only-Epithelial_alveolar-AT_1-Differentiating_AT1|LPS_only / Treatment groups by lineage, cell group, cell type

NAV2 ALAS1 NRXN3

2.34e-042002732dadf317a42a7e27cc1fac74f91b806c93a57108
ToppCellMacroglial-Oligodendrocytes-OPALIN-|Macroglial / cells hierarchy compared to all cells using T-Statistic

NRXN3 PTPRD FMN1

2.34e-042002738b229f095fc113aecfc94b64862a9e0fdcc363ce
ToppCellCOVID-19|World / Disease, condition lineage and cell class

KMT2C SETD2 CNOT1

2.34e-042002737dec470c379cd89f05a0f37c8628b21f136e52f0
ToppCellLPS_IL1RA_TNF-Epithelial_alveolar-AT_1-2_Progenitor-AT2_Progenitor|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

ALAS1 NRXN3 GALNT3

2.34e-04200273b6cfe5e205ade8bcb75555564f3f57f03f6e40be
DrugMidodrine hydrochloride [3092-17-9]; Up 200; 13.8uM; PC3; HT_HG-U133A

SETD2 BCL9 PRRC2B MED8 IQSEC2

2.02e-061952552087_UP
Drug3,4-dimethoxy-N-((2,2-dimethyl-2H-chromen-6-yl)methyl)-N-phenylbenzenesulfonamide

CREBBP EP300

1.16e-055252ctd:C575894
DrugNSC289491

SETD2 EP300

3.23e-058252CID000002693
DrugAC1NUW7G

SETD2 ALAS1 EP300

4.04e-0561253CID005462208
DrugCamptothecine (S,+) [7689-03-4]; Down 200; 11.4uM; PC3; HT_HG-U133A

NAV2 SETD2 CREBBP EP300

4.20e-051802544541_DN
Drugtrichostatin A, Streptomyces sp.; Down 200; 1uM; PC3; HT_HG-U133A

SETD2 PABPN1 CREBBP EP300

4.20e-051802546886_DN
DrugCP-690334-01 [459212-38-5]; Up 200; 10uM; PC3; HT_HG-U133A

REST GALNT3 TNS1 ADAM20

4.97e-051882543823_UP
Drug5707885; Down 200; 50uM; PC3; HT_HG-U133A

PTPRD GALNT3 BCL9 TNS1

5.29e-051912546390_DN
Drugpaclitaxel; Down 200; 0.1uM; MCF7; HG-U133A

BCL9 TNS1 ADAM20 EP300

5.62e-05194254640_DN
Drug(S)-(-)-Cycloserine [339-72-0]; Up 200; 39.2uM; PC3; HT_HG-U133A

DNAH3 PTPRD GALNT3 CREBBP

5.73e-051952543789_UP
DrugTetrandrine [518-34-3]; Down 200; 6.4uM; MCF7; HT_HG-U133A

SETD2 BCL9 PABPN1 IQSEC2

5.73e-051952546082_DN
DrugMerbromin [129-16-8]; Up 200; 5uM; PC3; HT_HG-U133A

NRXN3 GALNT3 TNS1 ADAM20

5.85e-051962543700_UP
DrugHydroxytacrine maleate (R,S) [118909-22-1]; Up 200; 12.2uM; MCF7; HT_HG-U133A

TNS1 CREBBP ADAM20 PRRC2B

5.96e-051972543292_UP
Drug0225151-0000 [351320-15-5]; Down 200; 10uM; PC3; HT_HG-U133A

NRXN3 PTPRD GALNT3 IQSEC2

5.96e-051972546389_DN
DrugCP-320650-01 [172079-28-6]; Down 200; 10uM; PC3; HT_HG-U133A

NRXN3 BCL9 TNS1 IQSEC2

5.96e-051972544557_DN
DrugLevonordefrin [829-74-3]; Down 200; 21.8uM; MCF7; HT_HG-U133A

NAV2 DNAH3 PABPN1 MED8

6.08e-051982543450_DN
DrugBetazole hydrochloride; Down 200; 27uM; PC3; HT_HG-U133A

TMCO6 DNAH3 REST PABPN1

6.08e-051982541812_DN
DrugPheniramine maleate [132-20-7]; Up 200; 11.2uM; PC3; HG-U133A

BCL9 CNOT1 EP300 PRRC2B

6.08e-051982541910_UP
DrugNaloxone hydrochloride [357-08-4]; Up 200; 11uM; PC3; HG-U133A

TMCO6 SETD2 BCL9 PRRC2B

6.08e-051982541924_UP
DrugCP-319743 [172078-87-4]; Up 200; 10uM; MCF7; HT_HG-U133A

DNAH3 GALNT3 TNS1 CREBBP

6.20e-051992547532_UP
Drugalpha-Santonin [481-06-1]; Down 200; 16.2uM; PC3; HT_HG-U133A

DNAH3 BCL9 TNS1 IQSEC2

6.20e-051992544531_DN
DiseaseMenke-Hennekam syndrome

CREBBP EP300

5.81e-072232cv:C5681632
DiseaseRubinstein-Taybi syndrome (implicated_via_orthology)

CREBBP EP300

5.81e-072232DOID:1933 (implicated_via_orthology)
DiseaseRubinstein-Taybi syndrome

CREBBP EP300

5.81e-072232cv:C0035934
DiseaseRUBINSTEIN-TAYBI SYNDROME 1

CREBBP EP300

5.81e-072232C4551859
DiseaseRubinstein-Taybi syndrome (is_implicated_in)

CREBBP EP300

5.81e-072232DOID:1933 (is_implicated_in)
DiseaseRUBINSTEIN-TAYBI SYNDROME 1

CREBBP EP300

5.81e-072232180849
DiseaseRubinstein-Taybi syndrome due to CREBBP mutations

CREBBP EP300

5.81e-072232cv:C4551859
DiseaseRubinstein-Taybi Syndrome

CREBBP EP300

5.81e-072232C0035934
DiseaseAdenoid Cystic Carcinoma

KMT2C SETD2 CREBBP EP300

1.05e-06100234C0010606
DiseaseCarcinoma, Transitional Cell

KMT2C CREBBP EP300

4.33e-0641233C0007138
DiseaseLeukemia, Myelocytic, Acute

KMT2C SETD2 CREBBP EP300

9.26e-06173234C0023467
DiseasePrecursor Cell Lymphoblastic Leukemia Lymphoma

SETD2 CREBBP EP300

1.45e-0561233C1961102
Diseaseforced expiratory volume

DGKB NRXN3 REST BCL9 TNS1 PRRC2B

2.45e-05789236EFO_0004314
DiseaseNeurodevelopmental Disorders

KMT2C SETD2 IQSEC2

5.13e-0593233C1535926
DiseaseSquamous cell carcinoma of esophagus

KMT2C CREBBP EP300

5.46e-0595233C0279626
Diseasedecreased susceptibility to hepatitis C infection

NAV2 PTPRD

6.93e-0516232EFO_0010101
Diseasebone mineral content measurement

DGKB PTPRD TNS1

1.39e-04130233EFO_0007621
DiseaseBladder Neoplasm

KMT2C CREBBP EP300

1.73e-04140233C0005695
DiseaseMalignant neoplasm of urinary bladder

KMT2C CREBBP EP300

1.76e-04141233C0005684
DiseaseSezary Syndrome

KMT2C CREBBP

2.02e-0427232C0036920
Diseasecoronary aneurysm

NAV2 NRXN3

3.40e-0435232EFO_1000881
Diseaselung adenocarcinoma (is_implicated_in)

KMT2C SETD2

6.68e-0449232DOID:3910 (is_implicated_in)
Diseaseghrelin measurement

DGKB SETD2

6.68e-0449232EFO_0600001
DiseaseSmall cell carcinoma of lung

CREBBP EP300

8.11e-0454232C0149925
DiseaseDiffuse Large B-Cell Lymphoma

CREBBP EP300

8.42e-0455232C0079744
Diseaseurate measurement, spine bone mineral density

NAV2 PTPRD

9.36e-0458232EFO_0004531, EFO_0007701
Diseasefish consumption measurement

DGKB CNOT1

1.14e-0364232EFO_0010139
DiseaseProstatic Neoplasms

KMT2C SETD2 GALNT3 CREBBP

1.21e-03616234C0033578
DiseaseMalignant neoplasm of prostate

KMT2C SETD2 GALNT3 CREBBP

1.21e-03616234C0376358
Diseaseelectroencephalogram measurement

DNAH3 PTPRD

1.52e-0374232EFO_0004357
Diseasesmoking status measurement

NAV2 NRXN3 REST PTPRD PRRC2B

1.73e-031160235EFO_0006527
DiseaseColorectal Carcinoma

KMT2C DNAH3 PTPRD EP300

1.96e-03702234C0009402

Protein segments in the cluster

PeptideGeneStartEntry
KKAVPGGGMPNMGQQ

EP300

291

Q09472
PPPKNNMEGLNVMGK

ADAM20

676

O43506
MKQQIGSPGQPNPMS

CREBBP

2301

Q92793
KDGMMQKPGSNAPVG

CT45A5

81

P0DMU8
KDGMMQKPGSNAPVG

CT45A7

81

P0DMV0
PMEGMASNQQKALPP

FMN1

856

Q68DA7
VEKGSAQMDPPQMGP

REST

601

Q13127
GINKVMAQNNLGMPP

KMT2C

3106

Q8NEZ4
QNCPKMMEVGAKPAP

ALAS1

31

P13196
KDGMMQKPGSNAPVG

CT45A10

81

P0DMU9
EKQKGMMRPNASQPG

IQSEC2

1096

Q5JU85
GMVPKLPAGKMNNRD

NRXN3

1491

Q9Y4C0
NEVEKQMNMSPPPGN

PABPN1

141

Q86U42
KSMQNPPGPVKLVME

DNAH3

2786

Q8TD57
NNIKDAMPKMQIGAP

GALNT3

71

Q14435
DGPQKKPEGPIQAMM

BCL9

396

O00512
GPQKMLMPSQFPNQG

BCL9L

831

Q86UU0
KITHKNQAPMLMGPP

DGKB

771

Q9Y6T7
KDGMMQKPGSNAPVG

CT45A6

81

P0DMU7
NGEPKGQPMLKDVML

PTPRD

756

P23468
MAQAGQPGKMPSGIK

MED8

241

Q96G25
PEAMKPAPNNQKSML

NAV2

411

Q8IVL1
MNKARQPPPGVMPKG

CNOT1

681

A5YKK6
PPPTIMQQNKKGDMT

TNS1

1506

Q9HBL0
PGMQPLEMVKPQSGS

PRRC2B

2026

Q5JSZ5
MLQMLQPGPKLNPGV

TMCO6

241

Q96DC7
MKQLQPQPPPKMGDF

SETD2

1

Q9BYW2