Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	oxoglutarate dehydrogenase (succinyl-transferring) activity	OGDHL OGDH	6.23e-05	4	65	2	GO:0004591
GeneOntologyMolecularFunction	thiamine pyrophosphate binding	OGDHL OGDH	2.88e-04	8	65	2	GO:0030976
GeneOntologyMolecularFunction	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	OGDHL OGDH	3.70e-04	9	65	2	GO:0016624
GeneOntologyBiologicalProcess	clathrin-dependent synaptic vesicle endocytosis	ITSN1 ITSN2	9.18e-06	2	63	2	GO:0150007
GeneOntologyCellularComponent	RecQ family helicase-topoisomerase III complex	BLM TOP3A	5.51e-05	4	64	2	GO:0031422
GeneOntologyCellularComponent	DNA helicase complex	BLM TOP3A	9.17e-05	5	64	2	GO:0033202
GeneOntologyCellularComponent	oxoglutarate dehydrogenase complex	OGDHL OGDH	4.99e-04	11	64	2	GO:0045252
GeneOntologyCellularComponent	dendritic spine	ITSN1 ARFGEF2 ACTN2 APP SHISA6	8.72e-04	242	64	5	GO:0043197
GeneOntologyCellularComponent	neuron spine	ITSN1 ARFGEF2 ACTN2 APP SHISA6	9.56e-04	247	64	5	GO:0044309
GeneOntologyCellularComponent	tricarboxylic acid cycle heteromeric enzyme complex	OGDHL OGDH	1.37e-03	18	64	2	GO:0045239
GeneOntologyCellularComponent	alpha-ketoacid dehydrogenase complex	OGDHL OGDH	1.37e-03	18	64	2	GO:0045240
GeneOntologyCellularComponent	lateral element	REC8 BLM	1.53e-03	19	64	2	GO:0000800
GeneOntologyCellularComponent	postsynaptic actin cytoskeleton	ITSN1 ACTN2	1.53e-03	19	64	2	GO:0098871
Domain	2-oxogl_dehyd_N	OGDHL OGDH	1.12e-05	2	63	2	PF16078
Domain	2-oxogl_dehyd_N	OGDHL OGDH	1.12e-05	2	63	2	IPR032106
Domain	PH_13	ITSN1 ITSN2	1.12e-05	2	63	2	PF16652
Domain	2oxoglutarate_DH_E1	OGDHL OGDH	3.35e-05	3	63	2	IPR011603
Domain	OxoGdeHyase_C	OGDHL OGDH	3.35e-05	3	63	2	PF16870
Domain	KGD_C	OGDHL OGDH	3.35e-05	3	63	2	IPR031717
Domain	E1_dh	OGDHL OGDH	1.67e-04	6	63	2	PF00676
Domain	DH_E1	OGDHL OGDH	1.67e-04	6	63	2	IPR001017
Domain	Transket_pyr	OGDHL OGDH	3.09e-04	8	63	2	SM00861
Domain	Transket_pyr	OGDHL OGDH	3.09e-04	8	63	2	PF02779
Domain	Transketolase-like_Pyr-bd	OGDHL OGDH	3.09e-04	8	63	2	IPR005475
Domain	EF-hand_4	ITSN1 ITSN2	4.95e-04	10	63	2	PF12763
Domain	EH	ITSN1 ITSN2	6.04e-04	11	63	2	PS50031
Domain	EH	ITSN1 ITSN2	6.04e-04	11	63	2	SM00027
Domain	EH_dom	ITSN1 ITSN2	6.04e-04	11	63	2	IPR000261
Domain	THDP-binding	OGDHL OGDH	8.53e-04	13	63	2	IPR029061
Domain	-	OGDHL OGDH	8.53e-04	13	63	2	3.40.50.970
Domain	C2	ITSN1 ITSN2 PRKCB FER1L6	1.00e-03	131	63	4	PF00168
Domain	C2	ITSN1 ITSN2 PRKCB FER1L6	1.18e-03	137	63	4	SM00239
Domain	C2	ITSN1 ITSN2 PRKCB FER1L6	1.35e-03	142	63	4	PS50004
Domain	-	ITSN1 ITSN2 PRKCB FER1L6	1.57e-03	148	63	4	2.60.40.150
Domain	C2_dom	ITSN1 ITSN2 PRKCB FER1L6	2.28e-03	164	63	4	IPR000008
Pathway	KEGG_TRYPTOPHAN_METABOLISM	CYP1A1 OGDHL ALDH2 OGDH	1.36e-05	40	52	4	M980
Pubmed	Evidence for BLM and Topoisomerase IIIalpha interaction in genomic stability.	BLM TOP3A	3.44e-06	2	65	2	11406610
Pubmed	Intersectin deficiency impairs cortico-striatal neurotransmission and causes obsessive-compulsive behaviors in mice.	ITSN1 ITSN2	3.44e-06	2	65	2	37603735
Pubmed	Amyloid-beta peptide levels in brain are inversely correlated with insulysin activity levels in vivo.	IDE APP	3.44e-06	2	65	2	12732730
Pubmed	Sequence variants of IDE are associated with the extent of beta-amyloid deposition in the Alzheimer's disease brain.	IDE APP	3.44e-06	2	65	2	15718037
Pubmed	The Bloom's syndrome gene product interacts with topoisomerase III.	BLM TOP3A	3.44e-06	2	65	2	10734115
Pubmed	Exon Inclusion Modulates Conformational Plasticity and Autoinhibition of the Intersectin 1 SH3A Domain.	ITSN1 ITSN2	3.44e-06	2	65	2	31031201
Pubmed	Intersectin associates with synapsin and regulates its nanoscale localization and function.	ITSN1 ITSN2	3.44e-06	2	65	2	29078407
Pubmed	The Bloom's syndrome helicase stimulates the activity of human topoisomerase IIIalpha.	BLM TOP3A	3.44e-06	2	65	2	12433984
Pubmed	Association of the Bloom syndrome protein with topoisomerase IIIalpha in somatic and meiotic cells.	BLM TOP3A	3.44e-06	2	65	2	10728666
Pubmed	Adaptor proteins intersectin 1 and 2 bind similar proline-rich ligands but are differentially recognized by SH2 domain-containing proteins.	ITSN1 ITSN2	3.44e-06	2	65	2	23936226
Pubmed	Elucidation of interactions of Alzheimer amyloid beta peptides (Abeta40 and Abeta42) with insulin degrading enzyme: a molecular dynamics study.	IDE APP	3.44e-06	2	65	2	20380468
Pubmed	Vertebrate intersectin1 is repurposed to facilitate cortical midline connectivity and higher order cognition.	ITSN1 ITSN2	3.44e-06	2	65	2	23447614
Pubmed	Mitochondrial aldehyde dehydrogenase-2 activation prevents β-amyloid-induced endothelial cell dysfunction and restores angiogenesis.	ALDH2 APP	3.44e-06	2	65	2	23447675
Pubmed	The human intersectin genes and their spliced variants are differentially expressed.	ITSN1 ITSN2	3.44e-06	2	65	2	11690630
Pubmed	Medium-Chain Length Fatty Acids Enhance Aβ Degradation by Affecting Insulin-Degrading Enzyme.	IDE APP	3.44e-06	2	65	2	34831163
Pubmed	The catalytic domain of insulin-degrading enzyme forms a denaturant-resistant complex with amyloid beta peptide: implications for Alzheimer disease pathogenesis.	IDE APP	3.44e-06	2	65	2	18411275
Pubmed	Amyloid precursor protein enhances Nav1.6 sodium channel cell surface expression.	SCN8A APP	3.44e-06	2	65	2	25767117
Pubmed	Insulin-degrading enzyme in brain microvessels: proteolysis of amyloid {beta} vasculotropic variants and reduced activity in cerebral amyloid angiopathy.	IDE APP	3.44e-06	2	65	2	15489232
Pubmed	Degradation of Alzheimer's Amyloid-β by a Catalytically Inactive Insulin-Degrading Enzyme.	IDE APP	3.44e-06	2	65	2	33865867
Pubmed	Prevention of axonal injury using calpain inhibitor in chronic progressive experimental autoimmune encephalomyelitis.	SCN8A APP	3.44e-06	2	65	2	18725211
Pubmed	cAMP/PKA signaling pathway contributes to neuronal apoptosis via regulating IDE expression in a mixed model of type 2 diabetes and Alzheimer's disease.	IDE APP	3.44e-06	2	65	2	28771808
Pubmed	Insulin-degrading enzyme rapidly removes the beta-amyloid precursor protein intracellular domain (AICD).	IDE APP	3.44e-06	2	65	2	11809755
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	PRR12 RIMKLB NELFB RNF213 FLRT2 MORC3 FMNL2 MEAK7	3.83e-06	493	65	8	15368895
Pubmed	Human topoisomerase IIIalpha is a single-stranded DNA decatenase that is stimulated by BLM and RMI1.	BLM TOP3A	1.03e-05	3	65	2	20445207
Pubmed	Replication protein A physically interacts with the Bloom's syndrome protein and stimulates its helicase activity.	BLM TOP3A	1.03e-05	3	65	2	10825162
Pubmed	Behavioral analysis in mice deficient for GAREM2 (Grb2-associated regulator of Erk/MAPK subtype2) that is a subtype of highly expressing in the brain.	ITSN1 ITSN2	1.03e-05	3	65	2	31718706
Pubmed	Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation.	IDE APP	1.03e-05	3	65	2	9830016
Pubmed	Amyloid precursor protein modulates Nav1.6 sodium channel currents through a Go-coupled JNK pathway.	SCN8A APP	1.03e-05	3	65	2	28008944
Pubmed	A double Holliday junction dissolvasome comprising BLM, topoisomerase IIIalpha, and BLAP75.	BLM TOP3A	1.03e-05	3	65	2	16595695
Pubmed	Intersectin 2, a new multimodular protein involved in clathrin-mediated endocytosis.	ITSN1 ITSN2	1.03e-05	3	65	2	10922467
Pubmed	Aggregation and catabolism of disease-associated intra-Abeta mutations: reduced proteolysis of AbetaA21G by neprilysin.	IDE APP	1.03e-05	3	65	2	18602473
Pubmed	BRI2 protein regulates β-amyloid degradation by increasing levels of secreted insulin-degrading enzyme (IDE).	IDE APP	1.03e-05	3	65	2	21873424
Pubmed	Association between polymorphisms in RMI1, TOP3A, and BLM and risk of cancer, a case-control study.	BLM TOP3A	1.03e-05	3	65	2	19432957
Pubmed	Holliday junction processing activity of the BLM-Topo IIIalpha-BLAP75 complex.	BLM TOP3A	1.03e-05	3	65	2	17728255
Pubmed	BLAP75/RMI1 promotes the BLM-dependent dissolution of homologous recombination intermediates.	BLM TOP3A	1.03e-05	3	65	2	16537486
Pubmed	Functional role of BLAP75 in BLM-topoisomerase IIIalpha-dependent holliday junction processing.	BLM TOP3A	1.03e-05	3	65	2	18390547
Pubmed	Modulation of Rack-1/PKCβII signalling by soluble AβPPα in SH-SY5Y cells.	PRKCB APP	1.03e-05	3	65	2	23905995
Pubmed	Phosphorylation of amyloid-β peptide at serine 8 attenuates its clearance via insulin-degrading and angiotensin-converting enzymes.	IDE APP	1.03e-05	3	65	2	22267728
Pubmed	CALHM1 ion channel elicits amyloid-β clearance by insulin-degrading enzyme in cell lines and in vivo in the mouse brain.	IDE APP	1.03e-05	3	65	2	25999473
Pubmed	Transcriptional regulation of insulin-degrading enzyme modulates mitochondrial amyloid β (Aβ) peptide catabolism and functionality.	IDE APP	2.06e-05	4	65	2	23525105
Pubmed	Statins promote the degradation of extracellular amyloid {beta}-peptide by microglia via stimulation of exosome-associated insulin-degrading enzyme (IDE) secretion.	IDE APP	2.06e-05	4	65	2	20876579
Pubmed	Crystal structures of RMI1 and RMI2, two OB-fold regulatory subunits of the BLM complex.	BLM TOP3A	2.06e-05	4	65	2	20826342
Pubmed	Notch signaling proteins HES-1 and Hey-1 bind to insulin degrading enzyme (IDE) proximal promoter and repress its transcription and activity: implications for cellular Aβ metabolism.	IDE APP	2.06e-05	4	65	2	22036964
Pubmed	Cleavage of the Bloom's syndrome gene product during apoptosis by caspase-3 results in an impaired interaction with topoisomerase IIIalpha.	BLM TOP3A	2.06e-05	4	65	2	11470874
Pubmed	Duplex DNA and BLM regulate gate opening by the human TopoIIIα-RMI1-RMI2 complex.	BLM TOP3A	2.06e-05	4	65	2	35102151
Pubmed	Insulin degrading enzyme contributes to the pathology in a mixed model of Type 2 diabetes and Alzheimer's disease: possible mechanisms of IDE in T2D and AD.	IDE APP	2.06e-05	4	65	2	29222348
Pubmed	Mammalian verprolin CR16 acts as a modulator of ITSN scaffold proteins association with actin.	ITSN1 ITSN2	2.06e-05	4	65	2	28161632
Pubmed	The dissolution of double Holliday junctions.	BLM TOP3A	2.06e-05	4	65	2	24984776
Pubmed	Mitochondrial aldehyde dehydrogenase (ALDH2) rescues cardiac contractile dysfunction in an APP/PS1 murine model of Alzheimer's disease via inhibition of ACSL4-dependent ferroptosis.	ALDH2 APP	2.06e-05	4	65	2	33767380
Pubmed	The EH and SH3 domain Ese proteins regulate endocytosis by linking to dynamin and Eps15.	ITSN1 ITSN2	2.06e-05	4	65	2	10064583
Pubmed	BLAP75, an essential component of Bloom's syndrome protein complexes that maintain genome integrity.	BLM TOP3A	2.06e-05	4	65	2	15775963
Pubmed	Rif1 provides a new DNA-binding interface for the Bloom syndrome complex to maintain normal replication.	BLM TOP3A	3.43e-05	5	65	2	20711169
Pubmed	Novel PRD-like homeodomain transcription factors and retrotransposon elements in early human development.	CPHXL CPHXL2	3.43e-05	5	65	2	26360614
Pubmed	Role of replication protein A in double holliday junction dissolution mediated by the BLM-Topo IIIα-RMI1-RMI2 protein complex.	BLM TOP3A	3.43e-05	5	65	2	23543748
Pubmed	Monopolar spindle 1 (MPS1) protein-dependent phosphorylation of RecQ-mediated genome instability protein 2 (RMI2) at serine 112 is essential for BLM-Topo III α-RMI1-RMI2 (BTR) protein complex function upon spindle assembly checkpoint (SAC) activation during mitosis.	BLM TOP3A	3.43e-05	5	65	2	24108125
Pubmed	Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism.	IDE APP	3.43e-05	5	65	2	17051221
Pubmed	Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	PRR12 RIMKLB ITSN2 OGDHL	4.27e-05	103	65	4	10574462
Pubmed	Identification of multi-SH3 domain-containing protein interactome in pancreatic cancer: a yeast two-hybrid approach.	DNAJA4 ITSN1 ITSN2 ARHGAP17	4.78e-05	106	65	4	18654987
Pubmed	Low-density lipoprotein receptor represents an apolipoprotein E-independent pathway of Aβ uptake and degradation by astrocytes.	IDE APP	5.13e-05	6	65	2	22383525
Pubmed	Genome instability and embryonic developmental defects in RMI1 deficient mice.	BLM TOP3A	5.13e-05	6	65	2	23900276
Pubmed	Enhancement of c-Myc degradation by BLM helicase leads to delayed tumor initiation.	BLM RBX1	5.13e-05	6	65	2	23750012
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	RIMKLB DNAJA4 ITSN1 ITSN2 DNAH2 OGDHL ACTN2 ALDH2 OGDH PLXNA2 FER1L6	6.84e-05	1442	65	11	35575683
Pubmed	EHSH1/intersectin, a protein that contains EH and SH3 domains and binds to dynamin and SNAP-25. A protein connection between exocytosis and endocytosis?	ITSN1 ITSN2	7.18e-05	7	65	2	10373452
Pubmed	Interaction between the helicases genetically linked to Fanconi anemia group J and Bloom's syndrome.	BLM TOP3A	7.18e-05	7	65	2	21240188
Pubmed	Effects of dietary intake and genetic factors on hypermethylation of the hMLH1 gene promoter in gastric cancer.	CYP1A1 ALDH2	9.56e-05	8	65	2	15991278
Pubmed	Neuropeptide Y receptor genes on human chromosome 4q31-q32 map to conserved linkage groups on mouse chromosomes 3 and 8.	TLL1 SI	9.56e-05	8	65	2	9169155
Pubmed	Molecular epidemiology of preterm delivery: methodology and challenges.	CYP1A1 ALDH2	1.23e-04	9	65	2	11520401
Pubmed	Cypher, a striated muscle-restricted PDZ and LIM domain-containing protein, binds to alpha-actinin-2 and protein kinase C.	PRKCB ACTN2	1.23e-04	9	65	2	10391924
Pubmed	Genetic polymorphisms in three Iranian populations with different risks of esophageal cancer, an ecologic comparison.	CYP1A1 ALDH2	1.23e-04	9	65	2	15327835
Pubmed	Scaffolding protein SPIDR/KIAA0146 connects the Bloom syndrome helicase with homologous recombination repair.	BLM TOP3A	1.53e-04	10	65	2	23509288
Pubmed	FANCM connects the genome instability disorders Bloom's Syndrome and Fanconi Anemia.	BLM TOP3A	1.53e-04	10	65	2	20064461
Pubmed	Role of p90 ribosomal S6 kinase-mediated prorenin-converting enzyme in ischemic and diabetic myocardium.	PRKCB ACTN2	1.87e-04	11	65	2	16585392
Pubmed	DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.	BLM PRR12 NELFB MED14 MORC3 TOP3A	2.04e-04	453	65	6	29656893
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	FZD7 PRR12 SCN8A MED14 ARFGEF2 ZDHHC7 OGDHL ARHGAP17 TOP3A	2.07e-04	1105	65	9	35748872
Pubmed	A gene expression map of human chromosome 21 orthologues in the mouse.	DNAJC28 ITSN1 MORC3 APP	2.24e-04	158	65	4	12466855
Pubmed	A multiprotein nuclear complex connects Fanconi anemia and Bloom syndrome.	BLM TOP3A	2.24e-04	12	65	2	12724401
Pubmed	Molecular and genetic characterization of GABP beta.	SI APP	2.24e-04	12	65	2	7958862
Pubmed	Hypoxia regulates Hippo signalling through the SIAH2 ubiquitin E3 ligase.	OGDHL OGDH	2.24e-04	12	65	2	25438054
Pubmed	A novel ubiquitin ligase is deficient in Fanconi anemia.	BLM TOP3A	2.24e-04	12	65	2	12973351
Pubmed	A human ortholog of archaeal DNA repair protein Hef is defective in Fanconi anemia complementation group M.	BLM TOP3A	2.24e-04	12	65	2	16116422
Pubmed	A Network of Conserved Synthetic Lethal Interactions for Exploration of Precision Cancer Therapy.	BLM ALDH2 TOP3A	2.51e-04	65	65	3	27453043
Pubmed	Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.	MRPS30 CYP1A1 CXorf38 OGDHL COA4 IDE ALDH2 OGDH TOP3A	2.54e-04	1136	65	9	34800366
Pubmed	The histone-fold complex MHF is remodeled by FANCM to recognize branched DNA and protect genome stability.	BLM TOP3A	2.65e-04	13	65	2	24699063
Pubmed	FCHo proteins are nucleators of clathrin-mediated endocytosis.	ITSN1 ITSN2	2.65e-04	13	65	2	20448150
Pubmed	Systematic analysis of human protein complexes identifies chromosome segregation proteins.	BLM DNAJA4 SERPINB12 ANAPC2 ITSN2 IDE MORC3 TOP3A MYBL1	2.86e-04	1155	65	9	20360068
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	ITSN1 ITSN2 ARFGEF2 OGDHL PRKCB ACTN2 ALDH2 OGDH FMNL2 ARPC1B	3.07e-04	1431	65	10	37142655
Pubmed	ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity.	ANAPC2 RBX1	3.08e-04	14	65	2	10230407
Pubmed	MHF1-MHF2, a histone-fold-containing protein complex, participates in the Fanconi anemia pathway via FANCM.	BLM TOP3A	3.08e-04	14	65	2	20347429
Pubmed	Cloning of ligand targets: systematic isolation of SH3 domain-containing proteins.	ITSN1 ITSN2	3.56e-04	15	65	2	9630982
Pubmed	A network of chaperones prevents and detects failures in membrane protein lipid bilayer integration.	OGDHL OGDH	3.56e-04	15	65	2	30737405
Pubmed	In the developing cerebral cortex: axonogenesis, synapse formation, and synaptic plasticity are regulated by SATB2 target genes.	FLRT2 PLXNA2	3.56e-04	15	65	2	36028553
Pubmed	The conserved RNA helicase YTHDC2 regulates the transition from proliferation to differentiation in the germline.	REC8 MYBL1	3.56e-04	15	65	2	29087293
Pubmed	Screening of genes involved in chromosome segregation during meiosis I: toward the identification of genes responsible for infertility in humans.	REC8 SPDYA	4.06e-04	16	65	2	20339383
Pubmed	hPrimpol1/CCDC111 is a human DNA primase-polymerase required for the maintenance of genome integrity.	BLM TOP3A	4.06e-04	16	65	2	24126761
Pubmed	Mouse pachytene checkpoint 2 (trip13) is required for completing meiotic recombination but not synapsis.	REC8 BLM	4.06e-04	16	65	2	17696610
Pubmed	Candidate gene association study of esophageal squamous cell carcinoma in a high-risk region in Iran.	CYP1A1 ALDH2	4.06e-04	16	65	2	19826048
Pubmed	A Tbx1-Six1/Eya1-Fgf8 genetic pathway controls mammalian cardiovascular and craniofacial morphogenesis.	ACTN2 PLXNA2	4.06e-04	16	65	2	21364285
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	BLM MRPS30 DNAJC28 ITSN2 OGDHL RNF213 IDE ALDH2 OGDH TOP3A	4.35e-04	1496	65	10	32877691
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	ITSN1 SCN8A NELFB DNAH2 RNF213 PRKCB FMNL2	4.44e-04	736	65	7	29676528
Pubmed	FAAP20: a novel ubiquitin-binding FA nuclear core-complex protein required for functional integrity of the FA-BRCA DNA repair pathway.	BLM TOP3A	5.16e-04	18	65	2	22343915
Cytoband	Ensembl 112 genes in cytogenetic band chr2q24	XIRP2 ACVR1C LY75	7.97e-04	127	65	3	chr2q24
Cytoband	16q24.1	ZDHHC7 MEAK7	1.01e-03	33	65	2	16q24.1
Cytoband	Xp11.4	CXorf38 MED14	1.08e-03	34	65	2	Xp11.4
Cytoband	Ensembl 112 genes in cytogenetic band chr7p13	OGDH URGCP	2.60e-03	53	65	2	chr7p13
Cytoband	12p13.31	RIMKLB C1RL	5.81e-03	80	65	2	12p13.31
CoexpressionAtlas	dev gonad_e11.5_F_SupCellPrec_Sry_top-relative-expression-ranked_1000	REC8 RIMKLB DNAJC28 RGS22 MED14 GPCPD1 RNF213 MORC3 FMNL2 PLXNA2 SHISA6	2.19e-05	791	64	11	gudmap_dev gonad_e11.5_F_SupCellPrec_Sry_1000
CoexpressionAtlas	dev gonad_e12.5_M_SertoliCell_Sox9_k-means-cluster#2_top-relative-expression-ranked_1000	DNAJC28 MED14 RNF213 PRKCB ALDH2 SHISA6	3.44e-05	204	64	6	gudmap_dev gonad_e12.5_M_SertoliCell_Sox9_k2_1000
CoexpressionAtlas	DevelopingKidney_e15.5_cortic collect duct_emap-28132_k-means-cluster#4_top-relative-expression-ranked_500	RIMKLB MED14 ARFGEF2 GPCPD1 IDE	1.33e-04	163	64	5	gudmap_developingKidney_e15.5_cortic collect duct_500_k4
CoexpressionAtlas	dev gonad_e12.5_F_SupCellPrec_Sry_top-relative-expression-ranked_1000	REC8 EFNA1 RGS22 ITSN2 MED14 GPCPD1 RNF213 ALDH2 FMNL2 SHISA6	1.35e-04	803	64	10	gudmap_dev gonad_e12.5_F_SupCellPrec_Sry_1000
CoexpressionAtlas	dev gonad_e13.5_F_SupCellPrec_Sry_top-relative-expression-ranked_1000	REC8 EFNA1 RGS22 ITSN2 GPCPD1 RNF213 ALDH2 LY75 FMNL2 SHISA6	1.36e-04	804	64	10	gudmap_dev gonad_e13.5_F_SupCellPrec_Sry_1000
Drug	bathophenanthroline	CYP1A1 APP	7.54e-06	2	63	2	ctd:C006686
Drug	Heida	CYP1A1 APP	7.54e-06	2	63	2	CID000007152
Drug	Lidocaone hydrochloride [73-78-9]; Down 200; 14.8uM; PC3; HG-U133A	DNAJA4 ITSN2 APP PLXNA2 TOP3A KRIT1	1.70e-05	196	63	6	1917_DN
Drug	HAHs	CYP1A1 IDE APP	1.90e-05	19	63	3	CID003035605
Drug	5-methyl-1,10-phenanthroline	CYP1A1 APP	2.26e-05	3	63	2	ctd:C017518
Drug	ginkgolide C	CYP1A1 APP	2.26e-05	3	63	2	ctd:C058295
Disease	oxoglutarate dehydrogenase deficiency (implicated_via_orthology)	OGDHL OGDH	4.34e-06	2	62	2	DOID:0081326 (implicated_via_orthology)
Disease	cerebral cavernous malformation (implicated_via_orthology)	RNF213 KRIT1	2.36e-04	11	62	2	DOID:0060669 (implicated_via_orthology)
Disease	Alzheimer's disease (implicated_via_orthology)	DNAJA4 IDE APP	2.38e-04	57	62	3	DOID:10652 (implicated_via_orthology)
Disease	heart disease (biomarker_via_orthology)	CYP1A1 ALDH2	5.79e-04	17	62	2	DOID:114 (biomarker_via_orthology)
Disease	Ischemic stroke, coronary artery disease	FZD7 TMEM132D RNF213	9.71e-04	92	62	3	EFO_0001645, HP_0002140
Disease	Calcium channel blocker use measurement	RIMKLB RNF213 ALDH2 ARPC1B	1.06e-03	213	62	4	EFO_0009930
Disease	aggressive behavior	ARFGEF2 F11	1.26e-03	25	62	2	EFO_0003015
Disease	1,5 anhydroglucitol measurement	EFNA1 SI	1.70e-03	29	62	2	EFO_0008009
Disease	coffee consumption	CYP1A1 ALDH2	2.07e-03	32	62	2	EFO_0004330
Disease	bitter non-alcoholic beverage consumption measurement	CYP1A1 ITSN1	2.07e-03	32	62	2	EFO_0010093

Protein segments in the cluster

Peptide	Gene	Start	Entry
AVNVNDRCQKICDQW	ACTN2	476	P35609
SDKQQCWCRQALEQF	ANAPC2	226	Q9UJX6
VEANQPVTIQNWCKR	APP	86	P05067
PRQKVLCVFWEHGQN	ADGRE2	476	Q9UHX3
WNKDRTQIAICPNNH	ARPC1B	16	O15143
CDQKFRPSIPNQWQS	ACVR1C	436	Q8NER5
SDVFAQLQWCVKQDN	ARFGEF2	1426	Q9Y6D5
QLQWCVKQDNEQLAR	ARFGEF2	1431	Q9Y6D5
QVELKEFCPNEQNWR	DNAJA4	361	Q8WW22
EFCPNEQNWRQHREA	DNAJA4	366	Q8WW22
NLKQLTARNNPWFCD	FLRT2	301	O43155
GQPWCEAQVFLNKNL	RAET1E	46	Q8TD07
RQVCPLDNREWEFQK	RBX1	91	P62877
PEKFQEQLQTRAHCW	REC8	316	O95072
RPDEWQNEKQKSVAC	RBM44	506	Q6ZP01
IPKGRCVFVNQWQIN	CYP1A1	401	P04798
RTIQDTLNPKWNFNC	ITSN2	1606	Q9NZM3
DKCQQAWEPNRFAAS	PLXNA2	541	O75051
DIQKRPDQTWVQCDA	MORC3	401	Q14149
FINDVEQCQWIRQKF	OGDHL	211	Q9ULD0
KQWNHVCEQFQENIR	DNAJC28	291	Q9NX36
CAVEVKRQIWQDNQA	NELFB	141	Q8WX92
AAKVQCSEQWIPFQN	LY75	946	O60449
SPLNICEENKQNNWE	KRIT1	391	O00522
KCSLNPEWNETFRFQ	PRKCB	216	P05771
EQQFDPLWKRRNVEC	PTPDC1	366	A2A3K4
SWEVKPQFQGDNRCF	MEAK7	311	Q6P9B6
PDQATQLKWNVQFCL	MED14	1326	O60244
NDLEQCQWIRQKFET	OGDH	226	Q02218
NKFGFQWPERLRCEN	FZD7	136	O75084
DVGFNIEIKWICQQR	GPCPD1	451	Q9NPB8
ARDEVQQKWINQDGC	BLM	926	P54132
QQKWINQDGCQVICA	BLM	931	P54132
EYQLCQPQSKDQVRW	EFNA1	76	P20827
FDCPVNVINNWFQNN	CPHXL2	61	A0A1W2PPK0
QDTLNPKWNSNCQFF	ITSN1	1636	Q15811
PKWNSNCQFFIRDLE	ITSN1	1641	Q15811
VAPREACNAWLQKRQ	C1RL	396	Q9NZP8
ACNAWLQKRQRPEVF	C1RL	401	Q9NZP8
FFSQEWPKESQRNLC	F11	241	P03951
WELICDQERFQVKNP	FMNL2	61	Q96PY5
AKCRQWLEKNFPNEF	DENR	51	O43583
RQFQPQCQVCAEWKR	CXorf38	71	Q8TB03
PQEWVFQECKDLNAV	IDE	406	P14735
NFLCNPTKVRDWNIQ	DNAH2	3356	Q9P225
FQCQHRWQKVLNPEL	MYBL1	71	P10243
DCPVNVIDNWFQNKR	CPHXL	66	A0A1W2PPM1
QRWKPFQQDVRCEVE	MCM9	246	Q9NXL9
QKNCADPVWHEQVIF	FER1L6	296	Q2WGJ9
TQADQNNPRKNICWG	MRPS30	381	Q9NP92
RPICKDNWQAFEKNT	SPDYA	36	Q5MJ70
NKNCVWQVVAPTQYR	TLL1	641	O43897
QRPKQEAAISCWVQF	TMEM132D	701	Q14C87
WPQFCEFRKNLTDEN	RGS22	1131	Q8NE09
WRTCQKLPPQNFVNF	ARHGAP17	361	Q68EM7
KLDQRQCTNYQSPVW	SHISA6	136	Q6ZSJ9
RNSSCFVEWIPNNVK	TUBB1	336	Q9H4B7
FERGQQNDVFVKWPN	SI	1311	P14410
QNDVFVKWPNTNDIC	SI	1316	P14410
QQCMRNQPWLEQLFD	PRR12	2006	Q9ULL5
PEKSRQEINFWVECQ	SERPINB12	151	Q96P63
QPEVFCNQIFINNEW	ALDH2	31	P05091
WRQCQPQVQAFKDCM	COA4	51	Q9NYJ1
VLNCRWLFENQPIDK	XIRP2	1061	A4UGR9
QQVKQFCIRVENDWH	RNF213	4261	Q63HN8
QVEKEFCQLQWAVDP	URGCP	506	Q8TCY9
NLRNKCVVWPINFNE	SCN8A	276	Q9UQD0
PQAILNCVNKFWTFQ	RIMKLB	106	Q9ULI2
QFRKWQSCNPLVLFE	TOP3A	101	Q13472
PWVNNCVGEKNQRFF	ZDHHC7	161	Q9NXF8
NWDTEQIQPGKRQCN	UNC79	1941	Q9P2D8