Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	cysteine-type endopeptidase inhibitor activity involved in apoptotic process	DPEP1 BIRC2 BIRC3	5.51e-05	24	62	3	GO:0043027
GeneOntologyBiologicalProcess	antibiotic metabolic process	DPEP1 ABCC2	8.60e-06	2	61	2	GO:0016999
GeneOntologyBiologicalProcess	response to metal ion	DPEP1 KCNB1 SLC25A39 KCNQ2 ABCC2 MAPK8 ADCY1 RYR2	2.91e-05	415	61	8	GO:0010038
GeneOntologyBiologicalProcess	cellular response to metal ion	DPEP1 KCNB1 SLC25A39 KCNQ2 MAPK8 ADCY1	4.56e-05	219	61	6	GO:0071248
GeneOntologyBiologicalProcess	lactam metabolic process	DPEP1 ABCC2	5.14e-05	4	61	2	GO:0072338
GeneOntologyBiologicalProcess	response to calcium ion	DPEP1 KCNB1 KCNQ2 ADCY1 RYR2	1.14e-04	161	61	5	GO:0051592
GeneOntologyBiologicalProcess	cellular response to calcium ion	DPEP1 KCNB1 KCNQ2 ADCY1	1.34e-04	88	61	4	GO:0071277
GeneOntologyBiologicalProcess	cell maturation	NEMP1 ERCC2 KCNB1 KCNQ2 RFX3 PTH1R	1.36e-04	267	61	6	GO:0048469
GeneOntologyBiologicalProcess	detection of chemical stimulus	OR5P3 OR5T1 OR11G2 OR10H3 OR10V1 OR10H4 EXTL3 RYR2	1.48e-04	524	61	8	GO:0009593
Domain	BIR	BIRC2 BIRC3	3.00e-04	8	62	2	SM00238
Domain	-	BIRC2 BIRC3	3.00e-04	8	62	2	1.10.1170.10
Domain	BIR	BIRC2 BIRC3	3.00e-04	8	62	2	PF00653
Domain	BIR_REPEAT_2	BIRC2 BIRC3	3.00e-04	8	62	2	PS50143
Domain	BIR_rpt	BIRC2 BIRC3	3.00e-04	8	62	2	IPR001370
Domain	BIR_REPEAT_1	BIRC2 BIRC3	3.00e-04	8	62	2	PS01282
Domain	Dynein_heavy_chain_D4_dom	DNAH6 DNAH7	9.62e-04	14	62	2	IPR024317
Domain	Dynein_HC_stalk	DNAH6 DNAH7	9.62e-04	14	62	2	IPR024743
Domain	Dynein_heavy_dom-2	DNAH6 DNAH7	9.62e-04	14	62	2	IPR013602
Domain	DHC_N2	DNAH6 DNAH7	9.62e-04	14	62	2	PF08393
Domain	MT	DNAH6 DNAH7	9.62e-04	14	62	2	PF12777
Domain	AAA_8	DNAH6 DNAH7	9.62e-04	14	62	2	PF12780
Domain	DHC_fam	DNAH6 DNAH7	1.11e-03	15	62	2	IPR026983
Domain	Dynein_heavy_dom	DNAH6 DNAH7	1.11e-03	15	62	2	IPR004273
Domain	Dynein_heavy	DNAH6 DNAH7	1.11e-03	15	62	2	PF03028
Domain	CARD	BIRC2 BIRC3	1.26e-03	16	62	2	SM00114
Domain	Olfact_rcpt	OR5P3 OR5T1 OR11G2 OR10H3 OR10V1 OR10H4	1.90e-03	393	62	6	IPR000725
Domain	TUDOR	SETDB1 PHF20L1	2.62e-03	23	62	2	PS50304
Domain	TUDOR	SETDB1 PHF20L1	3.61e-03	27	62	2	SM00333
Domain	CARD	BIRC2 BIRC3	3.88e-03	28	62	2	PF00619
Domain	Tudor	SETDB1 PHF20L1	4.44e-03	30	62	2	IPR002999
Domain	CARD	BIRC2 BIRC3	4.74e-03	31	62	2	IPR001315
Domain	CARD	BIRC2 BIRC3	5.36e-03	33	62	2	PS50209
Domain	VG_K_chnl	KCNB1 KCNQ2	5.36e-03	33	62	2	IPR028325
Domain	Ion_trans_dom	KCNB1 KCNQ2 RYR2	6.45e-03	114	62	3	IPR005821
Domain	Ion_trans	KCNB1 KCNQ2 RYR2	6.45e-03	114	62	3	PF00520
Domain	GPCR_Rhodpsn_7TM	OR5P3 OR5T1 OR11G2 OR10H3 OR10V1 OR10H4 CHRM3	6.59e-03	670	62	7	IPR017452
Domain	7tm_1	OR5P3 OR5T1 OR11G2 OR10H3 OR10V1 OR10H4 CHRM3	6.96e-03	677	62	7	PF00001
Domain	G_PROTEIN_RECEP_F1_1	OR5P3 OR5T1 OR11G2 OR10H3 OR10V1 OR10H4 CHRM3	7.41e-03	685	62	7	PS00237
Domain	G_PROTEIN_RECEP_F1_2	OR5P3 OR5T1 OR11G2 OR10H3 OR10V1 OR10H4 CHRM3	7.75e-03	691	62	7	PS50262
Domain	GPCR_Rhodpsn	OR5P3 OR5T1 OR11G2 OR10H3 OR10V1 OR10H4 CHRM3	7.81e-03	692	62	7	IPR000276
Pathway	PID_FAS_PATHWAY	PIK3CA BIRC2 BIRC3 MAPK8	9.46e-06	38	50	4	M94
Pubmed	TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2.	BIRC2 BIRC3 MAPK8	3.00e-07	8	62	3	11907583
Pubmed	Essential cytoplasmic translocation of a cytokine receptor-assembled signaling complex.	BIRC2 BIRC3 MAPK8	2.42e-06	15	62	3	18635759
Pubmed	Cellular inhibitors of apoptosis proteins cIAP1 and cIAP2 are increased after labour in foetal membranes and myometrium and are essential for TNF-α-induced expression of pro-labour mediators.	BIRC2 BIRC3	3.13e-06	2	62	2	25046208
Pubmed	Baculoviral inhibitors of apoptosis repeat containing (BIRC) proteins fine-tune TNF-induced nuclear factor κB and c-Jun N-terminal kinase signalling in mouse pancreatic beta cells.	BIRC2 BIRC3	3.13e-06	2	62	2	23250032
Pubmed	Self-termination of the terminator.	BIRC2 BIRC3	3.13e-06	2	62	2	19008929
Pubmed	Cellular inhibitors of apoptosis are global regulators of NF-κB and MAPK activation by members of the TNF family of receptors.	BIRC2 BIRC3	3.13e-06	2	62	2	22434933
Pubmed	Nuclear cIAP1 overexpression is a tumor stage- and grade-independent predictor of poor prognosis in human bladder cancer patients.	BIRC2 BIRC3	3.13e-06	2	62	2	21795072
Pubmed	BIRC2-BIRC3 amplification: a potentially druggable feature of a subset of head and neck cancers in patients with Fanconi anemia.	BIRC2 BIRC3	3.13e-06	2	62	2	34997070
Pubmed	Prognostic Significance of the BIRC2-BIRC3 Gene Signature in Head and Neck Squamous Cell Carcinoma.	BIRC2 BIRC3	3.13e-06	2	62	2	35985688
Pubmed	Genomic organization and physical map of the human inhibitors of apoptosis: HIAP1 and HIAP2.	BIRC2 BIRC3	3.13e-06	2	62	2	9892732
Pubmed	Ubiquitin-Mediated Regulation of RIPK1 Kinase Activity Independent of IKK and MK2.	BIRC2 BIRC3	3.13e-06	2	62	2	29452637
Pubmed	Cellular inhibitors of apoptosis (cIAP) 1 and 2 are increased in placenta from obese pregnant women.	BIRC2 BIRC3	3.13e-06	2	62	2	25113061
Pubmed	Genomic characterization of the mouse inhibitor of apoptosis protein 1 and 2 genes.	BIRC2 BIRC3	3.13e-06	2	62	2	9441758
Pubmed	c-IAP1 and c-IAP2 redundancy differs between T and B cells.	BIRC2 BIRC3	3.13e-06	2	62	2	23799077
Pubmed	Targeted ablation of the cellular inhibitor of apoptosis 1 (cIAP1) attenuates denervation-induced skeletal muscle atrophy.	BIRC2 BIRC3	3.13e-06	2	62	2	31126323
Pubmed	Combinatorial GxGxE CRISPR screen identifies SLC25A39 in mitochondrial glutathione transport linking iron homeostasis to OXPHOS.	SLC25A39 SLC25A37	3.13e-06	2	62	2	35513392
Pubmed	A comprehensive search for DNA amplification in lung cancer identifies inhibitors of apoptosis cIAP1 and cIAP2 as candidate oncogenes.	BIRC2 BIRC3	3.13e-06	2	62	2	12651874
Pubmed	IAPs: from caspase inhibitors to modulators of NF-kappaB, inflammation and cancer.	BIRC2 BIRC3	3.13e-06	2	62	2	20651737
Pubmed	Filamin B serves as a molecular scaffold for type I interferon-induced c-Jun NH2-terminal kinase signaling pathway.	FLNB MAPK8	3.13e-06	2	62	2	18815275
Pubmed	Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli.	BIRC2 BIRC3	3.13e-06	2	62	2	10797013
Pubmed	Tissue and zonal-specific expression of an olfactory receptor transgene.	OR10H3 OR10H4	3.13e-06	2	62	2	9412503
Pubmed	Subcellular expression of c-IAP1 and c-IAP2 in colorectal cancers: relationships with clinicopathological features and prognosis.	BIRC2 BIRC3	3.13e-06	2	62	2	14708638
Pubmed	Functional evaluation of the role of inhibitor of apoptosis proteins in chronic lymphocytic leukemia.	BIRC2 BIRC3	3.13e-06	2	62	2	15183896
Pubmed	Role of IAPs in prostate cancer progression: immunohistochemical study in normal and pathological (benign hyperplastic, prostatic intraepithelial neoplasia and cancer) human prostate.	BIRC2 BIRC3	3.13e-06	2	62	2	20078866
Pubmed	Degradation of cIAPs contributes to hepatocyte lipoapoptosis.	BIRC2 BIRC3	3.13e-06	2	62	2	24008361
Pubmed	Apoptosis regulator through modulating IAP expression (ARIA) controls the PI3K/Akt pathway in endothelial and endothelial progenitor cells.	PIK3CA BIRC2 BIRC3	7.01e-06	21	62	3	21593423
Pubmed	Inhibitor of apoptosis proteins, NAIP, cIAP1 and cIAP2 expression during macrophage differentiation and M1/M2 polarization.	BIRC2 BIRC3	9.37e-06	3	62	2	29518103
Pubmed	The ubiquitin-associated domain of cellular inhibitor of apoptosis proteins facilitates ubiquitylation.	BIRC2 BIRC3	9.37e-06	3	62	2	25065467
Pubmed	Smac mimetics activate the E3 ligase activity of cIAP1 protein by promoting RING domain dimerization.	BIRC2 BIRC3	9.37e-06	3	62	2	21393245
Pubmed	Assignment of human inhibitor of apoptosis protein (IAP) genes xiap, hiap-1, and hiap-2 to chromosomes Xq25 and 11q22-q23 by fluorescence in situ hybridization.	BIRC2 BIRC3	9.37e-06	3	62	2	8938457
Pubmed	Loss of cIAP1 attenuates soleus muscle pathology and improves diaphragm function in mdx mice.	BIRC2 BIRC3	9.37e-06	3	62	2	23184147
Pubmed	Cellular inhibitors of apoptosis cIAP1 and cIAP2 are required for innate immunity signaling by the pattern recognition receptors NOD1 and NOD2.	BIRC2 BIRC3	9.37e-06	3	62	2	19464198
Pubmed	Increased Expression of BIRC2, BIRC3, and BIRC5 from the IAP Family in Mesenchymal Stem Cells of the Umbilical Cord Wharton's Jelly (WJSC) in Younger Women Giving Birth Naturally.	BIRC2 BIRC3	9.37e-06	3	62	2	32322338
Pubmed	Inhibitor of apoptosis (IAP) proteins in regulation of inflammation and innate immunity.	BIRC2 BIRC3	9.37e-06	3	62	2	21447281
Pubmed	PERK-dependent regulation of IAP translation during ER stress.	BIRC2 BIRC3	9.37e-06	3	62	2	19029953
Pubmed	Gas1 is induced during and participates in excitotoxic neuronal death.	BIRC2 BIRC3	9.37e-06	3	62	2	11906213
Pubmed	Inhibitor of apoptosis proteins as novel targets in inflammatory processes.	BIRC2 BIRC3	9.37e-06	3	62	2	21817100
Pubmed	MMP13, Birc2 (cIAP1), and Birc3 (cIAP2), amplified on chromosome 9, collaborate with p53 deficiency in mouse osteosarcoma progression.	BIRC2 BIRC3	9.37e-06	3	62	2	19276372
Pubmed	IFN-γ-induced IL-27 and IL-27p28 expression are differentially regulated through JNK MAPK and PI3K pathways independent of Jak/STAT in human monocytic cells.	PIK3CA MAPK8	9.37e-06	3	62	2	23891538
Pubmed	Smac/DIABLO selectively reduces the levels of c-IAP1 and c-IAP2 but not that of XIAP and livin in HeLa cells.	BIRC2 BIRC3	9.37e-06	3	62	2	14960576
Pubmed	Structures of the cIAP2 RING domain reveal conformational changes associated with ubiquitin-conjugating enzyme (E2) recruitment.	BIRC2 BIRC3	9.37e-06	3	62	2	18784070
Pubmed	Expression of inhibitor of apoptosis proteins in small- and non-small-cell lung carcinoma cells.	BIRC2 BIRC3	9.37e-06	3	62	2	12243753
Pubmed	Predictive value of ERCC2, ABCC2 and MMP2 of response and long-term survival in locally advanced head and neck cancer patients treated with chemoradiotherapy.	ERCC2 ABCC2	9.37e-06	3	62	2	34309735
Pubmed	To fight or die - inhibitor of apoptosis proteins at the crossroad of innate immunity and death.	BIRC2 BIRC3	9.37e-06	3	62	2	20888210
Pubmed	A small molecule Smac mimic potentiates TRAIL- and TNFalpha-mediated cell death.	BIRC2 BIRC3	9.37e-06	3	62	2	15353805
Pubmed	GDC-0152 induces apoptosis through down-regulation of IAPs in human leukemia cells and inhibition of PI3K/Akt signaling pathway.	BIRC2 BIRC3	9.37e-06	3	62	2	25273171
Pubmed	Genetic polymorphisms and response to 5-fluorouracil, doxorubicin and cyclophosphamide chemotherapy in breast cancer patients.	ERCC2 ABCC2	9.37e-06	3	62	2	27527855
Pubmed	cIAP1/2 negatively regulate RANKL-induced osteoclastogenesis through the inhibition of NFATc1 expression.	BIRC2 BIRC3	9.37e-06	3	62	2	23126497
Pubmed	Future Therapeutic Directions for Smac-Mimetics.	BIRC2 BIRC3	9.37e-06	3	62	2	32053868
Pubmed	Expression of inhibitor of apoptosis proteins in B-cell non-Hodgkin and Hodgkin lymphomas.	BIRC2 BIRC3	9.37e-06	3	62	2	16983704
Pubmed	Sox9 sustains chondrocyte survival and hypertrophy in part through Pik3ca-Akt pathways.	PIK3CA MAPK8 PTH1R	1.36e-05	26	62	3	21367821
Pubmed	Catalytic-independent inhibition of cIAP1-mediated RIP1 ubiquitination by EGLN3.	BIRC2 BIRC3	1.87e-05	4	62	2	26612615
Pubmed	TRIM32 protein sensitizes cells to tumor necrosis factor (TNFα)-induced apoptosis via its RING domain-dependent E3 ligase activity against X-linked inhibitor of apoptosis (XIAP).	BIRC2 BIRC3	1.87e-05	4	62	2	21628460
Pubmed	cIAP1, cIAP2, and XIAP act cooperatively via nonredundant pathways to regulate genotoxic stress-induced nuclear factor-kappaB activation.	BIRC2 BIRC3	1.87e-05	4	62	2	19223549
Pubmed	cIAP1 Localizes to the nuclear compartment and modulates the cell cycle.	BIRC2 BIRC3	1.87e-05	4	62	2	15665297
Pubmed	A novel role for inhibitor of apoptosis (IAP) proteins as regulators of endothelial barrier function by mediating RhoA activation.	BIRC2 BIRC3	1.87e-05	4	62	2	24371121
Pubmed	CIAP2 inhibits anigen receptor signaling by targeting Bcl10 for degredation.	BIRC2 BIRC3	1.87e-05	4	62	2	16775419
Pubmed	A20 Promotes Ripoptosome Formation and TNF-Induced Apoptosis via cIAPs Regulation and NIK Stabilization in Keratinocytes.	BIRC2 BIRC3	1.87e-05	4	62	2	32028675
Pubmed	Shigella hijacks the glomulin-cIAPs-inflammasome axis to promote inflammation.	BIRC2 BIRC3	1.87e-05	4	62	2	29191979
Pubmed	Posttranscriptional downregulation of c-IAP2 by the ubiquitin protein ligase c-IAP1 in vivo.	BIRC2 BIRC3	1.87e-05	4	62	2	15798218
Pubmed	Cell adhesion tunes inflammatory TPL2 kinase signal transduction.	BIRC2 BIRC3	1.87e-05	4	62	2	35218437
Pubmed	Asymmetric recruitment of cIAPs by TRAF2.	BIRC2 BIRC3	1.87e-05	4	62	2	20447407
Pubmed	X-Linked inhibitor of apoptosis protein is involved in mutant SOD1-mediated neuronal degeneration.	BIRC2 BIRC3	1.87e-05	4	62	2	12153481
Pubmed	The USP19 deubiquitinase regulates the stability of c-IAP1 and c-IAP2.	BIRC2 BIRC3	1.87e-05	4	62	2	21849505
Pubmed	cIAP2 upregulated by E6 oncoprotein via epidermal growth factor receptor/phosphatidylinositol 3-kinase/AKT pathway confers resistance to cisplatin in human papillomavirus 16/18-infected lung cancer.	PIK3CA BIRC3	1.87e-05	4	62	2	20959404
Pubmed	Prognostic value of inhibitor of apoptosis protein family expression in patients with acute myeloid leukemia.	BIRC2 BIRC3	1.87e-05	4	62	2	25549803
Pubmed	The human anti-apoptotic proteins cIAP1 and cIAP2 bind but do not inhibit caspases.	BIRC2 BIRC3	1.87e-05	4	62	2	16339151
Pubmed	Expression of the inhibitor of apoptosis protein family in multiple sclerosis reveals a potential immunomodulatory role during autoimmune mediated demyelination.	BIRC2 BIRC3	1.87e-05	4	62	2	18566024
Pubmed	Small-molecule IAP antagonists sensitize cancer cells to TRAIL-induced apoptosis: roles of XIAP and cIAPs.	BIRC2 BIRC3	1.87e-05	4	62	2	24194568
Pubmed	IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases.	BIRC2 BIRC3	1.87e-05	4	62	2	9545235
Pubmed	Critical role for antiapoptotic Bcl-xL and Mcl-1 in human macrophage survival and cellular IAP1/2 (cIAP1/2) in resistance to HIV-Vpr-induced apoptosis.	BIRC2 BIRC3	1.87e-05	4	62	2	22403404
Pubmed	Inhibitor of Apoptosis Proteins (IAPs) Limit RIPK1-Mediated Skin Inflammation.	BIRC2 BIRC3	1.87e-05	4	62	2	28647349
Pubmed	Clinical Positioning of the IAP Antagonist Tolinapant (ASTX660) in Colorectal Cancer.	BIRC2 BIRC3	1.87e-05	4	62	2	34389694
Pubmed	Regulatory mechanisms of TRAF2-mediated signal transduction by Bcl10, a MALT lymphoma-associated protein.	BIRC2 BIRC3	1.87e-05	4	62	2	10753917
Pubmed	Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes.	BIRC2 BIRC3	1.87e-05	4	62	2	8552191
Pubmed	IAP-IAP complexes required for apoptosis resistance of C. trachomatis-infected cells.	BIRC2 BIRC3	1.87e-05	4	62	2	17069460
Pubmed	Cellular inhibitors of apoptosis proteins cIAP1 and cIAP2 are required for efficient caspase-1 activation by the inflammasome.	BIRC2 BIRC3	1.87e-05	4	62	2	22195745
Pubmed	An inactivating caspase 11 passenger mutation originating from the 129 murine strain in mice targeted for c-IAP1.	BIRC2 BIRC3	1.87e-05	4	62	2	22332634
Pubmed	Stabilization of C-terminal binding protein 2 by cellular inhibitor of apoptosis protein 1 via BIR domains without E3 ligase activity.	BIRC2 BIRC3	1.87e-05	4	62	2	32553630
Pubmed	The F-box protein Fbxo7 interacts with human inhibitor of apoptosis protein cIAP1 and promotes cIAP1 ubiquitination.	BIRC2 BIRC3	1.87e-05	4	62	2	16510124
Pubmed	Small-molecule SMAC mimetics as new cancer therapeutics.	BIRC2 BIRC3	1.87e-05	4	62	2	24841289
Pubmed	Apoptotic sensitivity of murine IAP-deficient cells.	BIRC2 BIRC3	1.87e-05	4	62	2	18684108
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	TANC2 ERCC2 TNRC18 HIVEP2 SLC25A39 KCNQ2 CFAP43 EXTL3 ANO8 IGSF3	2.41e-05	1105	62	10	35748872
Pubmed	Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy.	TCTN3 PHF20L1 DCAF17 ODC1 MAPK8 C2orf78 PKHD1L1 GARIN2	2.91e-05	686	62	8	29987050
Pubmed	Zinc finger protein 91 mediates necroptosis by initiating RIPK1-RIPK3-MLKL signal transduction in response to TNF receptor 1 ligation.	BIRC2 BIRC3	3.12e-05	5	62	2	34942311
Pubmed	Distinct BIR domains of cIAP1 mediate binding to and ubiquitination of tumor necrosis factor receptor-associated factor 2 and second mitochondrial activator of caspases.	BIRC2 BIRC3	3.12e-05	5	62	2	16282325
Pubmed	Monomerization of cytosolic mature smac attenuates interaction with IAPs and potentiation of caspase activation.	BIRC2 BIRC3	3.12e-05	5	62	2	20957035
Pubmed	Gliotoxin suppresses NF-κB activation by selectively inhibiting linear ubiquitin chain assembly complex (LUBAC).	BIRC2 BIRC3	3.12e-05	5	62	2	25494483
Pubmed	Identification of ARIA regulating endothelial apoptosis and angiogenesis by modulating proteasomal degradation of cIAP-1 and cIAP-2.	BIRC2 BIRC3	3.12e-05	5	62	2	19416853
Pubmed	Cartilage oligomeric matrix protein protects cells against death by elevating members of the IAP family of survival proteins.	BIRC2 BIRC3	3.12e-05	5	62	2	17993464
Pubmed	Cellular inhibitor of apoptosis protein-1 (cIAP1) can regulate E2F1 transcription factor-mediated control of cyclin transcription.	BIRC2 BIRC3	3.12e-05	5	62	2	21653699
Pubmed	A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death.	BIRC2 BIRC3	3.12e-05	5	62	2	11583623
Pubmed	Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins.	BIRC2 BIRC3	3.12e-05	5	62	2	10929712
Pubmed	MicroRNA-17 Suppresses TNF-α Signaling by Interfering with TRAF2 and cIAP2 Association in Rheumatoid Arthritis Synovial Fibroblasts.	BIRC2 BIRC3	3.12e-05	5	62	2	27534557
Pubmed	Primary Ciliary Dyskinesia Associated Disease-Causing Variants in CCDC39 and CCDC40 Cause Axonemal Absence of Inner Dynein Arm Heavy Chains DNAH1, DNAH6, and DNAH7.	DNAH6 DNAH7	3.12e-05	5	62	2	39056782
Pubmed	Receptor-interacting protein 1 increases chemoresistance by maintaining inhibitor of apoptosis protein levels and reducing reactive oxygen species through a microRNA-146a-mediated catalase pathway.	BIRC2 BIRC3	3.12e-05	5	62	2	24425875
Pubmed	IAP antagonists sensitize murine osteosarcoma cells to killing by TNFα.	BIRC2 BIRC3	3.12e-05	5	62	2	27129149
Pubmed	TNF-alpha induced c-IAP1/TRAF2 complex translocation to a Ubc6-containing compartment and TRAF2 ubiquitination.	BIRC2 BIRC3	3.12e-05	5	62	2	15861135
Pubmed	The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins.	BIRC2 BIRC3	3.12e-05	5	62	2	8548810
Pubmed	Involvement of caspase-2 and caspase-9 in endoplasmic reticulum stress-induced apoptosis: a role for the IAPs.	BIRC2 BIRC3	3.12e-05	5	62	2	16701639
Interaction	ALG6 interactions	DPEP1 TCTN3 LRP10 PTH1R	2.40e-06	32	60	4	int:ALG6
Interaction	CASP10 interactions	PHF20L1 BIRC2 BIRC3 MAPK8	1.60e-05	51	60	4	int:CASP10
Interaction	APLP2 interactions	LMBR1L PIK3CA BIRC3 EXTL3 MAPK8	3.26e-05	123	60	5	int:APLP2
Cytoband	11q22	BIRC2 BIRC3	9.79e-05	11	62	2	11q22
Cytoband	Ensembl 112 genes in cytogenetic band chr11q22	EXPH5 BIRC2 BIRC3	4.21e-04	107	62	3	chr11q22
GeneFamily	Ring finger proteins\|Baculoviral IAP repeat containing\|Caspase recruitment domain containing	BIRC2 BIRC3	1.68e-04	8	45	2	419
GeneFamily	Olfactory receptors, family 10	OR10H3 OR10V1 OR10H4	5.91e-04	66	45	3	157
GeneFamily	Dyneins, axonemal	DNAH6 DNAH7	8.04e-04	17	45	2	536
GeneFamily	WD repeat domain containing\|Caspase recruitment domain containing\|Apoptosome	BIRC2 BIRC3	2.52e-03	30	45	2	959
GeneFamily	Tudor domain containing	SETDB1 PHF20L1	3.82e-03	37	45	2	780
GeneFamily	Potassium voltage-gated channels	KCNB1 KCNQ2	4.45e-03	40	45	2	274
Coexpression	GSE40274_FOXP3_VS_FOXP3_AND_PBX1_TRANSDUCED_ACTIVATED_CD4_TCELL_DN	SHANK1 TCTN3 DCAF17 AP1M2 BIRC2 IGSF3	6.32e-06	199	60	6	M9184
ToppCell	Posterior_cortex\|World / BrainAtlas - Mouse McCarroll V32	HIVEP2 EXPH5 CHRM3 ADCY1 RYR2	2.85e-06	159	62	5	18e9fe2efbe0bca7c3990f3b12b6f549e2c1263a
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HIVEP2 KCNB1 KCNQ2 ADCY1 RYR2	7.32e-06	193	62	5	be28070c049e7cb68bcd54f582226eb2f5e4bc1c
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HIVEP2 KCNB1 KCNQ2 ADCY1 RYR2	7.32e-06	193	62	5	0c652ebe22ce5d2927599dd97ef1920547858395
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Neuronal-neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HIVEP2 KCNB1 KCNQ2 ADCY1 RYR2	7.32e-06	193	62	5	8689a70a33a7c3823dc647d41ac0160e7c3ae396
ToppCell	COVID-19-Epithelial\|COVID-19 / Condition, Lineage and Cell class	EXPH5 AP1M2 CFAP43 DNAH6 DNAH7	8.08e-06	197	62	5	18fd7344628a87d5c7ef5efb66e260a4136245bf
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	KCNB1 CFAP43 RFX3 DNAH6 DNAH7	8.08e-06	197	62	5	74a2c6cb8fcfe53dd9a2b36492a16c58f38e51c9
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW12-Neuronal-Interneuron\|GW12 / Sample Type, Dataset, Time_group, and Cell type.	SHANK1 SLC7A4 CHRM3 PTH1R	2.80e-05	125	62	4	eafc39072467e209c9fe3a4fa41cb09507a42e82
ToppCell	368C-Fibroblasts-Fibroblast-F-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	SLC7A4 ABCC2 DNAH7 ANO8	5.55e-05	149	62	4	9286bc56ff2e245630537a0bda5f1a1e17be863a
ToppCell	368C-Fibroblasts-Fibroblast-F\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	SLC7A4 ABCC2 DNAH7 ANO8	5.55e-05	149	62	4	f53151d9e5e724a61be0ee6a8c740d1990f28d5f
ToppCell	Hippocampus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Calb2-Excitatory_Neuron.Slc17a7.Calb2-Vgll3_(Dentate_hilum?)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	DPEP1 PKHD1L1 G6PC1	8.06e-05	60	62	3	aa75fef294803ec6396c7d2c1f51d52bc4a5b43f
ToppCell	Hippocampus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Calb2-Excitatory_Neuron.Slc17a7.Calb2-Vgll3_(Dentate_hilum?)-\|Hippocampus / BrainAtlas - Mouse McCarroll V32	DPEP1 PKHD1L1 G6PC1	8.06e-05	60	62	3	069fbabfd0e48e5809ff01a026439fd0bd017779
ToppCell	C_02\|World / shred on cell type and cluster	DPEP1 FLNB ABCC2 G6PC1	8.24e-05	165	62	4	a456c2c9ffe8dc91e17cac84ba87b88e016f8e6d
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DPEP1 ABCC2 G6PC1 PTH1R	8.84e-05	168	62	4	fa0d251693935116adf633d02b7ec4a295100865
ToppCell	5'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CFAP43 RFX3 DNAH6 DNAH7	9.04e-05	169	62	4	fba841664939c771881ba97f14ef1df6635c04ff
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CFAP43 RFX3 DNAH6 DNAH7	9.04e-05	169	62	4	14aadc2d1bf66eb47dac33b4d61ddb3c942caa4f
ToppCell	facs-Diaphragm-Limb_Muscle-24m\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HIVEP2 DNAH6 PKHD1L1 RYR2	9.04e-05	169	62	4	12bdc709bc000d7f9061ecd9fbd57233eaacb7e2
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DPEP1 ABCC2 G6PC1 PTH1R	9.46e-05	171	62	4	f5014e3c387fe3118944af392abe10d6b9b0abab
ToppCell	3'-Distal_airway-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CFAP43 RFX3 DNAH6 DNAH7	9.90e-05	173	62	4	c3762655caa79ac4879876f470d32578a3c93b01
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	DPEP1 ABCC2 G6PC1 PTH1R	9.90e-05	173	62	4	8888434641ea554a9b62c436e87920378eef29cd
ToppCell	critical-Myeloid-pDC\|critical / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	DPEP1 ST6GALNAC4 ODC1 PKHD1L1	9.90e-05	173	62	4	e8508c3efbe0f0fae51484a5535d43103c810d4e
ToppCell	droplet-Marrow-nan-24m\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC25A39 ODC1 FAHD1 SLC25A37	1.06e-04	176	62	4	f92063b72ebfeb9b192281dc63d6bf2759c78554
ToppCell	facs-Kidney-nan-18m-Epithelial\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC25A39 FAHD1 G6PC1 PTH1R	1.08e-04	177	62	4	7f58286fc8797e9bdcf8ece0849f55680905955d
ToppCell	droplet-Marrow-nan-24m-Myeloid\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OTUD5 SLC25A39 FAHD1 SLC25A37	1.10e-04	178	62	4	b4e15c176875cd226854a0019495309d02730c42
ToppCell	COVID-19-kidney-PCT-S1/S2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	DPEP1 ABCC2 G6PC1 PTH1R	1.10e-04	178	62	4	23a12d3d971b857d5be8e907334d1f6b49eeeb32
ToppCell	droplet-Marrow-nan-24m-Myeloid-nan\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OTUD5 SLC25A39 FAHD1 SLC25A37	1.13e-04	179	62	4	7e6da098976c7801d31dcc0201f813d2bc8b07fc
ToppCell	5'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CFAP43 RFX3 DNAH6 DNAH7	1.13e-04	179	62	4	5e5f1cdf4aa66868d45b74ba91e20e848a3cbaff
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DPEP1 ABCC2 G6PC1 PTH1R	1.15e-04	180	62	4	f8bdfd7bf7b3d52c659a29d8f5f80858e79da83e
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	DPEP1 ABCC2 G6PC1 PTH1R	1.15e-04	180	62	4	1363b3254470f6ff98630d1df83a1bdbacc137e0
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DPEP1 ABCC2 G6PC1 PTH1R	1.23e-04	183	62	4	facd6dbe0851b537d70a899ac7485714ab27d071
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	DPEP1 ABCC2 G6PC1 PTH1R	1.23e-04	183	62	4	84b64cf728629c3af9a8d2ed15b93adf562c54b8
ToppCell	droplet-Kidney-nan-18m-Epithelial-Epcam____kidney_proximal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DPEP1 ABCC2 G6PC1 PTH1R	1.25e-04	184	62	4	c86ed59fed687cdaaf7e9c4418d2e3e2c4111cca
ToppCell	Ciliated_cells-A-Myositis-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	CFAP43 RFX3 DNAH6 DNAH7	1.25e-04	184	62	4	07c5a9633ccdcd18771e3230d6198a55c400afa6
ToppCell	droplet-Kidney-nan-18m-Epithelial-kidney_proximal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DPEP1 ABCC2 G6PC1 PTH1R	1.25e-04	184	62	4	7c256bcfa07c5ff55aad0833e8712b0456b5832b
ToppCell	COVID-19-kidney-Mito-rich_PCT\|COVID-19 / Disease (COVID-19 only), tissue and cell type	DPEP1 ABCC2 G6PC1 PTH1R	1.28e-04	185	62	4	1bbc2ba8a20f72f61981b1301cdd6018cdd9150d
ToppCell	droplet-Kidney-nan-3m-Epithelial-Epcam____kidney_proximal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DPEP1 ABCC2 G6PC1 PTH1R	1.28e-04	185	62	4	3e3217c99719fd1d2fa94e16be7712a7e5077152
ToppCell	critical-Myeloid-pDC\|Myeloid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	DPEP1 ST6GALNAC4 ODC1 PKHD1L1	1.28e-04	185	62	4	4a5d1d0a757f1f4fdb911be96ed90b52182c25f0
ToppCell	droplet-Kidney-nan-3m-Epithelial-kidney_proximal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DPEP1 ABCC2 G6PC1 PTH1R	1.28e-04	185	62	4	0ff4148b4701003d9d594e0da8261176fb13aa59
ToppCell	Ciliated_cells-B-Myositis-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	CFAP43 RFX3 DNAH6 DNAH7	1.28e-04	185	62	4	f012c243343e1d1956db19b34d062e9b13de2b2a
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HIVEP2 KCNB1 KCNQ2 RYR2	1.31e-04	186	62	4	7278a1a1bf9bb27aeb03852134defb31b62f30d6
ToppCell	multiciliated\|World / shred by cell class for bronchial biopsy	CFAP43 RFX3 DNAH6 DNAH7	1.36e-04	188	62	4	6833c1f0f265ef5448fa65033550ed7efc2f8d7b
ToppCell	droplet-Marrow-nan-24m-Hematologic-erythroblast\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ODC1 FAHD1 PKHD1L1 SLC25A37	1.39e-04	189	62	4	98ace332c3c046694c6ade47de8c8bf57ec51271
ToppCell	COPD-Epithelial-Ciliated\|Epithelial / Disease state, Lineage and Cell class	CFAP43 RFX3 DNAH6 DNAH7	1.39e-04	189	62	4	3e77883db34722b9ce0a03ea74caefc92dc7feff
ToppCell	droplet-Marrow-nan-3m-Hematologic-erythroblast\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ODC1 FAHD1 PKHD1L1 SLC25A37	1.39e-04	189	62	4	8a38baee58a27c2fa3f4bd131ab9f15723ed9295
ToppCell	Epithelial_cells-Ciliated_cells-B\|Epithelial_cells / lung cells shred on cell class, cell subclass, sample id	CFAP43 RFX3 DNAH6 DNAH7	1.42e-04	190	62	4	426a4806f6e39d4d57c6746609d30bb3ca62df7d
ToppCell	Nasal_Brush-Epithelial-Ciliated_2\|Nasal_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X	CFAP43 RFX3 DNAH6 DNAH7	1.42e-04	190	62	4	9ce7df056bfb24d70db4c3c4a2c57d89115de877
ToppCell	(0)_Myeloid-(01)_Dendritic_cell\|(0)_Myeloid / immune cells in Peripheral Blood (logTPM normalization)	TCTN3 FLNB ST6GALNAC4 ODC1	1.42e-04	190	62	4	e9507bb0c8ff3d071402731a9b8cfe1bba93fab0
ToppCell	Nasal_Brush-Epithelial-Ciliated_2\|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X	CFAP43 RFX3 DNAH6 DNAH7	1.42e-04	190	62	4	833481ace2800354712e2ce709d5cdfd0aed3d42
ToppCell	droplet-Heart-nan-24m-Hematologic-erythrocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NUP210L SLC25A39 SLC25A37	1.45e-04	73	62	3	30374f4d30519ca8cd9582da1f9f906420e50244
ToppCell	droplet-Marrow-BM-1m-Hematologic-erythroblast\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ODC1 FAHD1 PKHD1L1 SLC25A37	1.45e-04	191	62	4	d78d4fbb0b8317dbf14e32182466a432abef3e93
ToppCell	multiciliated\|World / shred by cell class for turbinate	CFAP43 RFX3 DNAH6 DNAH7	1.48e-04	192	62	4	0f89ea0deb651ca11531c51ee94e0233608d22ea
ToppCell	Bronchial_Biopsy-Epithelial-Ciliated_1\|Bronchial_Biopsy / Tissue, Lineage and Cell class of Lung Cells from 10X	CFAP43 RFX3 DNAH6 DNAH7	1.48e-04	192	62	4	be592e661367affced9ebe80849b466e6adb3a34
ToppCell	Bronchial_Biopsy-Epithelial-Ciliated_1\|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X	CFAP43 RFX3 DNAH6 DNAH7	1.51e-04	193	62	4	0b62a6ddd7c42efd9f39781971d1438501e1fa8d
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.3\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CFAP43 RFX3 DNAH6 DNAH7	1.51e-04	193	62	4	e1b76102f812c433195d1e8811fdd3293a7bc22e
ToppCell	Control-Epithelial-Ciliated\|Epithelial / Disease state, Lineage and Cell class	CFAP43 RFX3 DNAH6 DNAH7	1.51e-04	193	62	4	0e37d454f3735edd936ee9a5f5f516ac3aad400e
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.3\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	KCNB1 CFAP43 DNAH6 DNAH7	1.51e-04	193	62	4	bdb7401dd9059032f930f2b575f2ef8e504b6594
ToppCell	NS-moderate-d_0-4\|moderate / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	EXPH5 CFAP43 DNAH6 DNAH7	1.51e-04	193	62	4	ea345d34440b25f65358a53dc72831998d1c3620
ToppCell	15-Trachea-Epithelial-Multiciliated_cell\|Trachea / Age, Tissue, Lineage and Cell class	CFAP43 RFX3 DNAH6 DNAH7	1.51e-04	193	62	4	aa3acc7571405169efb656d214f3a8cbf988362e
ToppCell	IPF-Epithelial-Ciliated\|Epithelial / Disease state, Lineage and Cell class	CFAP43 RFX3 DNAH6 DNAH7	1.51e-04	193	62	4	ad58f5080e0ba65c845056ea6b79037b636e9c64
ToppCell	Bronchial_Brush-Epithelial-Ciliated_1\|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X	CFAP43 RFX3 DNAH6 DNAH7	1.54e-04	194	62	4	7a7ddccfe72a4a0dc4d1a5c809988f0069f9f1a3
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CFAP43 RFX3 DNAH6 DNAH7	1.54e-04	194	62	4	4a2c127c90d1fefe604fcb9e796577d21b489dd6
ToppCell	Bronchial_Brush-Epithelial-Ciliated_1\|Bronchial_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X	CFAP43 RFX3 DNAH6 DNAH7	1.54e-04	194	62	4	b4ce60c06568123008b1081d644733cb91c28f51
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CFAP43 RFX3 DNAH6 DNAH7	1.54e-04	194	62	4	a46238514bca920c3e3713d23c18ba24a09e2a29
ToppCell	normal_Lung-Epithelial_cells-Ciliated\|Epithelial_cells / Location, Cell class and cell subclass	CFAP43 RFX3 DNAH6 DNAH7	1.57e-04	195	62	4	a3e2999fdd4c3575add6e28ecfd1d6606a61f992
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CFAP43 RFX3 DNAH6 DNAH7	1.57e-04	195	62	4	93b1559382a12cfb158aa5fac7386e38b4f87989
ToppCell	3'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CFAP43 RFX3 DNAH6 DNAH7	1.57e-04	195	62	4	649fd2336e963f6a150d182a53ad5dd838ca80b1
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CFAP43 RFX3 DNAH6 DNAH7	1.57e-04	195	62	4	0e763f36786515698b593e5c93f6a56619c1242d
ToppCell	3'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CFAP43 RFX3 DNAH6 DNAH7	1.57e-04	195	62	4	129ad5f4253ecb1a8477cc38773e6e91ea9570b0
ToppCell	3'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CFAP43 RFX3 DNAH6 DNAH7	1.57e-04	195	62	4	3e70ee987d66d450062d5df3d7c733ccc7344470
ToppCell	moderate-Epithelial-Ciliated\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	CFAP43 RFX3 DNAH6 DNAH7	1.57e-04	195	62	4	3486eae5fdb062a75a907b896c9d7b396d2aa195
ToppCell	moderate-Epithelial-Ciliated\|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	CFAP43 RFX3 DNAH6 DNAH7	1.57e-04	195	62	4	e80f5cdf0b18066b3e6c2f5452e58f101c67932c
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CFAP43 RFX3 DNAH6 DNAH7	1.57e-04	195	62	4	9651ee03738226ee10e901f8b9ec6a417eb9c301
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HIVEP2 KCNB1 CHRM3 RYR2	1.57e-04	195	62	4	2e1df01bf6e4e98e6cd9fb50926e34c5077b8666
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CFAP43 RFX3 DNAH6 DNAH7	1.57e-04	195	62	4	581b04220587e1d5198b1abd6965965ace7803e7
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC7A4 KCNB1 KCNQ2 CHRM3	1.57e-04	195	62	4	ffbab350e67d9c4b66c0ab84550daec8b8139a27
ToppCell	ASK452\|World / Donor, Lineage and Cell class of Lung cells from Dropseq	HIVEP2 BIRC3 SLC25A37 RYR2	1.57e-04	195	62	4	7efd9d3a3f5e7dfe9698a4143ce4a0f9bf3a862c
ToppCell	COVID-19-Epithelial-Ciliated_cells\|Epithelial / Condition, Lineage and Cell class	CFAP43 RFX3 DNAH6 DNAH7	1.60e-04	196	62	4	de7aa31354b019d7321a8ef965d59ce2e8b89276
ToppCell	NS-moderate-d_07-13-Epithelial-Ciliated-diff\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	CFAP43 RFX3 DNAH6 DNAH7	1.60e-04	196	62	4	9a91a6e5f93ce3bb5a0fc63677553f4c2df95c43
ToppCell	critical-Epithelial-Ciliated\|critical / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	CFAP43 RFX3 DNAH6 DNAH7	1.60e-04	196	62	4	27b855c6e1ae44f16db998cf0e81bd686b9cee7e
ToppCell	NS-control-d_0-4-Epithelial-Ciliated\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	CFAP43 RFX3 DNAH6 DNAH7	1.60e-04	196	62	4	d46ab80554dd3c1cc81e1938ea2acfd5e85c6d2a
ToppCell	5'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CFAP43 RFX3 DNAH6 DNAH7	1.63e-04	197	62	4	87db09f341e2b20eb6e1c3e917cb5c960387b3e9
ToppCell	wk_20-22-Epithelial\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	AP1M2 CFAP43 DNAH6 DNAH7	1.63e-04	197	62	4	468071c1911cdf8e8806a78dbceb95379e28ae91
ToppCell	5'-Airway_Nasal-Epithelial-Airway_ciliated\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CFAP43 RFX3 DNAH6 DNAH7	1.63e-04	197	62	4	91637bdeab85024b5a02d1066f76cb803a2d6420
ToppCell	NS-moderate-d_0-4-Epithelial-Ciliated\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	CFAP43 RFX3 DNAH6 DNAH7	1.63e-04	197	62	4	71fea4aa6ce96c7693fa94792d08770622873850
ToppCell	5'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CFAP43 RFX3 DNAH6 DNAH7	1.63e-04	197	62	4	22c87dd15dc57bd0aa98a204c9fc9b3b9b573b45
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.4\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CFAP43 RFX3 DNAH6 DNAH7	1.63e-04	197	62	4	d83c61d2b5742e463122e1a98c7197a5b5b3d41b
ToppCell	5'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CFAP43 RFX3 DNAH6 DNAH7	1.63e-04	197	62	4	3bbf068d2ad8196fbc85d3f311a7c54c9aece856
ToppCell	control-Epithelial-Ciliated\|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	CFAP43 RFX3 DNAH6 DNAH7	1.63e-04	197	62	4	d4e963c1f82996371bf3d63578ee9fce8e00c5a8
ToppCell	ASK452-Epithelial-Transformed_epithelium\|Epithelial / Donor, Lineage and Cell class of Lung cells from Dropseq	ODC1 PKHD1L1 SLC25A37 RYR2	1.63e-04	197	62	4	e92757e988888347c74286cc42c262b03159b0b9
ToppCell	control-Epithelial-Ciliated\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	CFAP43 RFX3 DNAH6 DNAH7	1.63e-04	197	62	4	e453d085182364ca347cbcc9dc995c62c3353016
ToppCell	COVID-19-COVID-19_Mild-Others-RBC\|COVID-19_Mild / Disease, condition lineage and cell class	SLC25A39 ST6GALNAC4 CHRM3 SLC25A37	1.63e-04	197	62	4	3bae601e5d9689ea57e923814af8cdcae690becc
ToppCell	Somatosensory_Cortex_(S1)-Neuronal\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HIVEP2 KCNB1 CHRM3 RYR2	1.66e-04	198	62	4	c01091ef18e096d792ea2a7a715764a5b215355f
ToppCell	critical-Epithelial-Ciliated\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	CFAP43 RFX3 DNAH6 DNAH7	1.66e-04	198	62	4	ee2c8385c0bf4ea9f5c9517b52cf131af3fbdd40
ToppCell	proximal-Epithelial-Ciliated\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CFAP43 RFX3 DNAH6 DNAH7	1.69e-04	199	62	4	9700f06e51ddca85e482b4f9bd4a79bfcd3cfb76
ToppCell	mLN-(1)_T_cell-(16)_Tfh\|mLN / shred on region, Cell_type, and subtype	OR11G2 LRP10 BIRC3 KDSR	1.69e-04	199	62	4	c66fb7473c4bd990685ff47c3d9168d10ef39c9b
ToppCell	proximal-3-Epithelial-Ciliated\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CFAP43 RFX3 DNAH6 DNAH7	1.69e-04	199	62	4	1188afad6fd5f01f9aeba225f611f38b237dd2c9
ToppCell	mLN-T_cell-Tfh\|T_cell / Region, Cell class and subclass	OR11G2 LRP10 BIRC3 KDSR	1.69e-04	199	62	4	a234f14ff46a0dc2f916a80e1e7af7d793006050
ToppCell	MS-Multiple_Sclerosis-Others-RBC\|Multiple_Sclerosis / Disease, condition lineage and cell class	SLC25A39 BIRC2 ST6GALNAC4 SLC25A37	1.69e-04	199	62	4	b9e7549f67bc33284bacf9a160b3916651659809
ToppCell	Sepsis-ICU-NoSEP-Lymphocyte-B-B_memory\|ICU-NoSEP / Disease, condition lineage and cell class	BIRC3 ODC1 PKHD1L1 RYR2	1.69e-04	199	62	4	acd2b87ab0d7d92515cf46ab65b766d6ade818a6
ToppCell	mLN-T_cell-Tfh\|mLN / Region, Cell class and subclass	OR11G2 LRP10 BIRC3 KDSR	1.69e-04	199	62	4	65b7dea8ec19df9afc5cc06bb632c2e70e30a5da
ToppCell	proximal-Epithelial-Ciliated-3\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CFAP43 RFX3 DNAH6 DNAH7	1.69e-04	199	62	4	2e8ace105c4e2405baa06d953e52888b54e2d055
Disease	rectal benign neoplasm (is_implicated_in)	PIK3CA MAPK8	1.18e-05	3	59	2	DOID:1984 (is_implicated_in)
Disease	hepatocellular carcinoma (is_implicated_in)	ERCC2 PIK3CA BIRC3 G6PC1	4.79e-04	181	59	4	DOID:684 (is_implicated_in)
Disease	Disproportionate short stature	TCTN3 FLNB PTH1R	5.00e-04	77	59	3	C0878659
Disease	osteochondrodysplasia (is_implicated_in)	FLNB PTH1R	6.58e-04	19	59	2	DOID:2256 (is_implicated_in)
Disease	Alopecia	ODC1 ABCC2	6.58e-04	19	59	2	C0002170
Disease	chronic myeloid leukemia (is_implicated_in)	ERCC2 ABCC2	8.05e-04	21	59	2	DOID:8552 (is_implicated_in)
Disease	colorectal carcinoma (is_implicated_in)	PIK3CA BIRC3	8.85e-04	22	59	2	DOID:0080199 (is_implicated_in)
Disease	HIV Coinfection	BIRC2 BIRC3 ODC1	1.17e-03	103	59	3	C4505456
Disease	HIV Infections	BIRC2 BIRC3 ODC1	1.17e-03	103	59	3	C0019693
Disease	response to tenofovir, creatinine clearance measurement	OR5T1 CHRM3 RYR2	1.48e-03	112	59	3	EFO_0007934, EFO_0009279
Disease	caudate nucleus volume	TSEN2 LIN9	1.65e-03	30	59	2	EFO_0004830
Disease	fatty liver disease (biomarker_via_orthology)	ABCC2 G6PC1	1.99e-03	33	59	2	DOID:9452 (biomarker_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
VMYSSGLVRLYSFQT	DCAF17	226	Q5H9S7
ITPGTQYFMTLTYSG	CFAP43	396	Q8NDM7
EIPYFTVSGIQVRYM	AP1M2	381	Q9Y6Q5
GMYYSVSSQPITETS	C2orf78	266	A6NCI8
ITFGTAIAAFYMPVT	CHRM3	231	P20309
SFTSYSPYVTELIME	CEP44	46	Q9C0F1
YRMSTYSTFPAGVPV	BIRC3	31	Q13489
VPRTGSAYLFTYVSM	SLC7A4	96	O43246
TSAMVYPAVFGSVLY	ANO8	256	Q9HCE9
SYSPEMGRVVSVAYT	OR10V1	266	Q8NGI7
NVTITYSYAGARAPM	LRP10	111	Q7Z4F1
YSMPISIEFQRRYAT	LIN9	376	Q5TKA1
AVTYVPLTAGMYTLT	FLNB	1191	O75369
TVTVPMYSSQTQTYG	KCNQ2	366	O43526
AGTSFMMTPYVVTRY	MAPK8	176	P45983
SRSQIFYYSTGMTVG	NEMP1	181	O14524
RAVIMFGVPYVYTQS	ERCC2	616	P18074
TFSPRTSTIYDMYRT	EXPH5	286	Q8NEV8
ETSSMIFSIPYIISY	FAHD1	161	Q6P587
GIIYVSVQMFYVSTS	ABCC2	1131	Q92887
SYSRRISTATPYMNG	PIK3CA	306	P42336
YSDALMATTYTVFTP	OR10H3	271	O60404
YSDALMATTYTVFTP	OR10H4	271	Q8NGA5
TILFMYVRPSSSYTS	OR5T1	266	Q8NG75
YQSYSQVGVMFASIP	ADCY1	861	Q08828
YRPVATQGSVMYFVI	DNAH6	3291	Q9C0G6
IVSTMDSSFPYAIYT	IGSF3	71	O75054
ATITMTTVGYGDIYP	KCNB1	371	Q14721
SSPQLGRSTYMETYV	DNASE1L1	86	P49184
VYYVMVTSTLSIFQG	G6PC1	126	P35575
AMVAQSTFYTVQYRP	EXTL3	296	O43909
IEAAMRRYPTTYTQS	DNAH7	3766	Q8WXX0
RRYPTTYTQSMNTVL	DNAH7	3771	Q8WXX0
MYPETFLYVTSSAGI	DPEP1	111	P16444
GYRMYRKSQTTGFPS	PPP3CB	296	P16298
MQTSTYYYSVRIFPG	RYR2	1421	Q92736
YLGSVYPSRAVITTM	KDSR	146	Q06136
TFNGFQRPTIYYVMS	ODC1	396	P11926
VTPIYYVFFTSMVVT	NIPAL1	306	Q6NVV3
MYNRPVEVYQYSTGT	OTUD5	291	Q96G74
VYVMGVTSTQTPFSF	NUP210L	1191	Q5VU65
VSLFYGSVLVMYGSP	OR11G2	286	Q8NGC1
SRSMFTEKTTTYQYP	PHF20L1	611	A8MW92
TDVTTFTAILTPYMY	GARIN2	206	Q8N9W8
AFTVVQPTFRTTYMA	TSEN2	331	Q8NCE0
FYLMVSSVVGFYSSP	LMBR1L	361	Q6UX01
AIRTTTYPYTETQMY	RFX3	71	P48380
AFYRSYTTQLTMNIP	SLC25A37	196	Q9NYZ2
LYTNTVLSGGTTMYP	POTEJ	956	P0CG39
MSVYRSQSGSPVRYQ	TANC2	1551	Q9HCD6
YEVISMGTSVTGLYP	MROH2B	1146	Q7Z745
FYGTITFIYVMPKSS	OR5P3	251	Q8WZ94
MSVVTESSRNYGYNP	SETDB1	1051	Q15047
YSAVPGRSFMAVKSY	SHANK1	551	Q9Y566
ELYRMSTYSTFPAGV	BIRC2	46	Q13490
YLAGTYEPTTGMIFS	TNRC18	2946	O15417
QLTRMYPGLQVYTFT	ST6GALNAC4	171	Q9H4F1
LVMTVPATAIYFTAY	SLC25A39	131	Q9BZJ4
YIVFMATPYTEVSGT	PTH1R	421	Q03431
PQSYVYMVTFISTRG	PKHD1L1	591	Q86WI1
SYYNFTVLKVPRSMT	TCTN3	276	Q6NUS6
VRIQTHVPSYGSVMY	HIVEP2	1336	P31629
VSSMLSAYYVAFVPV	TMEM39B	291	Q9GZU3