Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
MousePhenofused tracheal cartilage rings

FGFR2 PAX9

1.84e-054252MP:0004552
MousePhenoarrest of tooth development

FGFR2 PAX9

6.41e-057252MP:0000118
DomainRasGAP

NF1 RASAL1

2.24e-0414302SM00323
DomainRasGAP_CS

NF1 RASAL1

2.24e-0414302IPR023152
DomainRAS_GTPASE_ACTIV_2

NF1 RASAL1

2.59e-0415302PS50018
DomainRasGAP

NF1 RASAL1

2.59e-0415302PF00616
DomainRAS_GTPASE_ACTIV_1

NF1 RASAL1

2.59e-0415302PS00509
DomainRasGAP_dom

NF1 RASAL1

3.76e-0418302IPR001936
Domain-

IGFN1 FGFR2 CAMTA1 ICAM5 PRLR EPB42

5.60e-046633062.60.40.10
DomainIg-like_fold

IGFN1 FGFR2 CAMTA1 ICAM5 PRLR EPB42

7.80e-04706306IPR013783
DomainPkinase_Tyr

FGFR2 TEX14 ALK

1.14e-03129303PF07714
DomainSer-Thr/Tyr_kinase_cat_dom

FGFR2 TEX14 ALK

1.38e-03138303IPR001245
DomainIg_I-set

IGFN1 FGFR2 ICAM5

3.44e-03190303IPR013098
DomainI-set

IGFN1 FGFR2 ICAM5

3.44e-03190303PF07679
DomainIGc2

IGFN1 FGFR2 ICAM5

6.21e-03235303SM00408
DomainIg_sub2

IGFN1 FGFR2 ICAM5

6.21e-03235303IPR003598
DomainTyrKc

FGFR2 ALK

8.76e-0388302SM00219
DomainTyr_kinase_cat_dom

FGFR2 ALK

8.76e-0388302IPR020635
DomainRho_GTPase_activation_prot

NF1 RASAL1

8.76e-0388302IPR008936
DomainPROTEIN_KINASE_TYR

FGFR2 ALK

1.06e-0297302PS00109
DomainTyr_kinase_AS

FGFR2 ALK

1.06e-0297302IPR008266
DomainIg_E-set

CAMTA1 EPB42

1.21e-02104302IPR014756
Pubmed

Genetic inhibition of Anaplastic Lymphoma Kinase rescues cognitive impairments in Neurofibromatosis 1 mutant mice.

NF1 ALK

8.73e-07233228057529
Pubmed

Pharmacological inhibition of Anaplastic Lymphoma Kinase rescues spatial memory impairments in Neurofibromatosis 1 mutant mice.

NF1 ALK

8.73e-07233228629962
Pubmed

Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease.

LPAL2 LPA

2.62e-06333219198611
Pubmed

Functional Variant in the SLC22A3-LPAL2-LPA Gene Cluster Contributes to the Severity of Coronary Artery Disease.

LPAL2 LPA

2.62e-06333227417586
Pubmed

Lack of association between four SNPs in the SLC22A3-LPAL2-LPA gene cluster and coronary artery disease in a Chinese Han population: a case control study.

LPAL2 LPA

2.62e-06333223036009
Pubmed

5' control regions of the apolipoprotein(a) gene and members of the related plasminogen gene family.

LPAL2 LPA

2.62e-0633327679504
Pubmed

Genetic variants, plasma lipoprotein(a) levels, and risk of cardiovascular morbidity and mortality among two prospective cohorts of type 2 diabetes.

LPAL2 LPA

5.23e-06433221900290
Pubmed

Genetic and clinical correlates of early-outgrowth colony-forming units.

LPAL2 LPA

8.72e-06533221493818
Pubmed

Shox2-deficient mice exhibit a rare type of incomplete clefting of the secondary palate.

FGFR2 PAX9

1.83e-05733216141225
Pubmed

The cellular and molecular etiology of the cleft secondary palate in Fgf10 mutant mice.

FGFR2 PAX9

2.44e-05833215572143
Pubmed

Development of the thymus requires signaling through the fibroblast growth factor receptor R2-IIIb.

FGFR2 PAX9

3.13e-05933211489975
Pubmed

Combinatorial CRISPR-Cas9 screens for de novo mapping of genetic interactions.

FGFR2 NF1 ALK

4.26e-057133328319113
Pubmed

The Mn1 transcription factor acts upstream of Tbx22 and preferentially regulates posterior palate growth in mice.

FGFR2 PAX9

7.89e-051433218948418
Pubmed

Embryonic submandibular gland morphogenesis: stage-specific protein localization of FGFs, BMPs, Pax6 and Pax9 in normal mice and abnormal SMG phenotypes in FgfR2-IIIc(+/Delta), BMP7(-/-) and Pax6(-/-) mice.

FGFR2 PAX9

1.04e-041633211731698
Pubmed

Frs2α enhances fibroblast growth factor-mediated survival and differentiation in lens development.

FGFR2 ALK

1.18e-041733223136392
Pubmed

FOG-2 attenuates endothelial-to-mesenchymal transformation in the endocardial cushions of the developing heart.

NF1 SMAD6

1.18e-041733217274974
Pubmed

FAM20B-catalyzed glycosaminoglycans control murine tooth number by restricting FGFR2b signaling.

FGFR2 PAX9

1.99e-042233232664967
Pubmed

Signaling integration in the rugae growth zone directs sequential SHH signaling center formation during the rostral outgrowth of the palate.

FGFR2 PAX9

3.25e-042833219782673
Pubmed

Fgfr2b mediated epithelial-mesenchymal interactions coordinate tooth morphogenesis and dental trigeminal axon patterning.

FGFR2 PAX9

3.25e-042833217951031
Pubmed

p63 regulates multiple signalling pathways required for ectodermal organogenesis and differentiation.

FGFR2 PAX9

3.74e-043033216524929
Pubmed

Identification and analysis of key circRNAs in the mouse embryonic ovary provides insight into primordial follicle development.

PRLR SMAD6

3.74e-043033238310234
Pubmed

Gene expression profiling in the developing secondary palate in the absence of Tbx1 function.

FGFR2 PAX9

4.81e-043433229866044
Pubmed

An FGF autocrine loop initiated in second heart field mesoderm regulates morphogenesis at the arterial pole of the heart.

FGFR2 SMAD6

5.09e-043533218832392
Pubmed

Epicardial-myocardial signaling directing coronary vasculogenesis.

FGFR2 SMAD6

5.69e-043733220299672
Pubmed

GLI3 constrains digit number by controlling both progenitor proliferation and BMP-dependent exit to chondrogenesis.

FGFR2 PAX9

5.69e-043733222465667
Pubmed

Targeting promiscuous heterodimerization overcomes innate resistance to ERBB2 dimerization inhibitors in breast cancer.

FGFR2 ALK

6.66e-044033230898150
Pubmed

The chromatin regulator Brpf1 regulates embryo development and cell proliferation.

PAX9 THSD7A

6.66e-044033225773539
Pubmed

hnRNPU in Sertoli cells cooperates with WT1 and is essential for testicular development by modulating transcriptional factors Sox8/9.

FGFR2 PRLR

8.06e-044433234815802
Pubmed

Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.

TAF1C RASAL1 SMAD6

8.12e-0419333322589738
Pubmed

Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.

TUBGCP6 FGFR2 NF1 SULF1 DENND4C SMAD6

8.85e-04121533615146197
CytobandEnsembl 112 genes in cytogenetic band chr6q25

PLEKHG1 LPAL2

6.23e-03164332chr6q25
GeneFamilyReceptor Tyrosine Kinases|CD molecules

FGFR2 ALK

7.14e-0440182321
GeneFamilyBlood group antigens|CD molecules|I-set domain containing|Immunoglobulin like domain containing

IGFN1 FGFR2

1.10e-02161182593
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

PLEKHG1 RASAL1

1.75e-02206182682
ToppCellAdult-Endothelial-endothelial_cell_of_artery-D175|Adult / Lineage, Cell type, age group and donor

PCDH11X TEX14 THSD7A SULF1 SMAD6

1.83e-071753350a65ddfa8c2e8efb5b5338cf07661cb78157a23c
ToppCell3'-GW_trimst-1-LargeIntestine-Endothelial-blood_vessel_EC-Mature_arterial_EC|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PCDH11X PLEKHG1 THSD7A FAM124B SULF1

2.75e-0719033592fdfed12061ee9f6c7171cf8a7f3344921f2d40
ToppCellbackground-Endothelial_cells|background / Sample and Cell Type and Tumor Cluster (all cells)

PLEKHG1 THSD7A DENND4C SMAD6 CCSER1

3.20e-07196335e6fb0bfab1779ec64a8c35d01519eaafbf62e977
ToppCellFetal_29-31_weeks-Endothelial-endothelial_cell_of_artery-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

THSD7A FAM124B SULF1 SMAD6

6.11e-0616233425bb1b9709f960fdf90faff56e874f52a8f5d17e
ToppCellPND14-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CMKLR1 THSD7A SULF1 SMAD6

6.73e-061663347a45785a40b7425f97be67bab1c5ceb69b2bd85a
ToppCellPND14-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CMKLR1 THSD7A SULF1 SMAD6

6.73e-06166334bbd382812f8a84a5d99888de2d7cca3a8b5e4695
ToppCellAdult-Endothelial-endothelial_cell_of_artery-D122|Adult / Lineage, Cell type, age group and donor

PCDH11X THSD7A SULF1 SMAD6

7.05e-061683348c3e1e45b422813bcdfa4273b1167db649a312f5
ToppCell3'-Adult-Appendix-Epithelial-mature_enterocytic-Colonocyte|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FGFR2 TAF1C RASAL1 TMC6

8.47e-0617633423fa02d4c39e0b8faa1658116d50b6233a952ccc
ToppCell3'-Adult-Appendix-Epithelial-mature_enterocytic|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FGFR2 TAF1C RASAL1 TMC6

8.47e-0617633430adf8f1638c6244586f8101c2590bb964dfae00
ToppCellFetal_29-31_weeks-Endothelial-endothelial_cell_of_artery|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

THSD7A FAM124B SULF1 SMAD6

8.67e-061773345ff8dcfb030312126695d53a026d2e104a401b83
ToppCellChildren_(3_yrs)-Epithelial-basal_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

FGFR2 PAX9 SULF1 LPA

8.86e-06178334fba2e38c05cbf031e0c6d47b1602575fea734a57
ToppCellCOVID-19-kidney-AQP1+SLC14A1+EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

PLEKHG1 THSD7A SULF1 SMAD6

9.06e-061793341ce8d18f63e8dd2d3db41fbeca4601bd3b305fba
ToppCellCOVID-19-Heart-EC_2|COVID-19 / Disease (COVID-19 only), tissue and cell type

PLEKHG1 THSD7A FAM124B SMAD6

9.06e-061793342a53d94f6c30bf887dfe88f1693ea057218c852d
ToppCell5'-GW_trimst-2-SmallIntestine-Endothelial-blood_vessel_EC-Mature_arterial_EC|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

THSD7A FAM124B SULF1 SMAD6

9.46e-061813340ba91575fe8851788cebc4cf5a6d76680bf586c5
ToppCell5'-Adult-LymphNode-Endothelial-blood_vessel_EC-Mature_arterial_EC|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PCDH11X THSD7A FAM124B SMAD6

9.67e-061823340639011cdd1c437ea8b7230896a4e6e5d7244ac2
ToppCellCOVID-19-kidney-Distal_Epi_Doublet_(PCT)|COVID-19 / Disease (COVID-19 only), tissue and cell type

THSD7A PRLR RASAL1 CCSER1

9.67e-061823349d67717a6e13bcb54c1297a3e4e3abf4e51628a3
ToppCellAdult-Epithelial-basal_cell|Adult / Lineage, Cell type, age group and donor

FGFR2 PAX9 SULF1 LPA

9.88e-0618333400a6b19ca49e3b8e0d1cd387a3515b0ff4b81c81
ToppCellP28-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_artery|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

CMKLR1 THSD7A SULF1 SMAD6

1.01e-051843348ed22b1af04a711203293e7a8b3df6fb9222fad5
ToppCellControl-Endothelial-Endothelial-Artery|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

THSD7A FAM124B SULF1 SMAD6

1.05e-051863342d3a975d2bf92e18e3410dd413fc9f84831d82de
ToppCellAdult-Endothelial-endothelial_cell_of_artery|Adult / Lineage, Cell type, age group and donor

PCDH11X THSD7A SULF1 SMAD6

1.05e-051863342d1c4ea2e401db89971582ee54618a8b0c81b8ac
ToppCellCOVID-19-Heart-EC_2|Heart / Disease (COVID-19 only), tissue and cell type

PLEKHG1 THSD7A FAM124B SMAD6

1.08e-0518733440ffc06a3e3251d9b12da390210d3e045af7537a
ToppCellCOVID-19-kidney|COVID-19 / Disease (COVID-19 only), tissue and cell type

THSD7A PRLR RASAL1 CCSER1

1.08e-05187334d23aae9419d460b78b1d4092d7acd9108a47cfbe
ToppCellP15-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_artery|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

CMKLR1 THSD7A SULF1 SMAD6

1.10e-0518833450b27fc12347ca16bd62333baf345c83cb422a8f
ToppCellP07-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_artery|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

CMKLR1 THSD7A SULF1 SMAD6

1.10e-051883345bc1537e079c7435196c163bff5f639ea392a33a
ToppCellEndothelial-Endothelial-E|Endothelial / shred on cell class and cell subclass (v4)

CASP1 CMKLR1 THSD7A SULF1

1.10e-051883342777eb7689b271c199021fe7d9db88ccebff14de
ToppCellLPS-IL1RA+antiTNF-Endothelial-Endothelial-Artery|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PLEKHG1 THSD7A FAM124B SMAD6

1.12e-05189334c45734970036e6d28d5e3fe7c9458fae38a3f624
ToppCellPCW_07-8.5-Epithelial-Epithelial_alveolar-distal-epi_SOX9^high_Etv5^high_distal_(10)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

PLEKHG1 FGFR2 PRLR CCSER1

1.15e-05190334625c08a0e5227efc46daa512fd579c3938ff76c7
ToppCellLPS-IL1RA-Endothelial-Endothelial-Artery|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

THSD7A FAM124B SULF1 SMAD6

1.15e-05190334aed65d584ca0c25f6a8313c66b421a6618af82ea
ToppCellfacs-Lung-3m-Endothelial-arterial_endothelial|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CMKLR1 THSD7A SULF1 SMAD6

1.17e-051913346e6b2cb390cc5cd0356924a2c36fbe5b5bd5966c
ToppCellfacs-Lung-3m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CMKLR1 THSD7A SULF1 SMAD6

1.17e-05191334482db995930346be69072ace2fd78fd453e97fb5
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PCDH11X PLEKHG1 SULF1 SMAD6

1.17e-05191334b2c86cde341fe350143658c8a8a4a9edbce3f19b
ToppCellLPS-antiTNF-Endothelial-Endothelial-Artery|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

THSD7A FAM124B SULF1 SMAD6

1.17e-051913344b3d5157344dbfbf4fab518611cd9fa37fac7bd9
ToppCellLPS-IL1RA+antiTNF-Endothelial-Endothelial-Gen_Cap|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PLEKHG1 THSD7A FAM124B CCSER1

1.22e-05193334e09387af84d2a0a526e54d4793e6e06c6739db53
ToppCellRV-10._Endothelium_II|RV / Chamber and Cluster_Paper

PCDH11X PLEKHG1 THSD7A SMAD6

1.22e-0519333401c2df9206f1527c578e808978e58196c35e72f5
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PLEKHG1 CMKLR1 SULF1 SMAD6

1.22e-051933340b328f725f6feba263783eaca60c142e80df90f3
ToppCellLPS-antiTNF-Endothelial-Endothelial-Gen_Cap|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PLEKHG1 THSD7A FAM124B CCSER1

1.22e-051933346e1982d089a9de628e6006d23ff78a223fbd9f47
ToppCellRV-10._Endothelium_II|World / Chamber and Cluster_Paper

PCDH11X PLEKHG1 THSD7A SMAD6

1.22e-051933342531266bc57339d4e2b22a88817008e32b8c1598
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PCDH11X PLEKHG1 THSD7A SMAD6

1.22e-051933342e72309607902dabe3218888b22a77fe941f3570
ToppCellLPS-IL1RA-Endothelial-Endothelial-Gen_Cap|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PLEKHG1 THSD7A FAM124B CCSER1

1.24e-051943340b9cd96fa0b616da7cc90e92ff71157e9bba518f
ToppCellnucseq-Endothelial-Endothelial_Vascular-Endothelial_large_blood_vessel|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

PLEKHG1 THSD7A SULF1 SMAD6

1.27e-05195334023e3c97dd3696d74f002ff8da0c04d876c82aef
ToppCellTracheal-NucSeq-Endothelial-Endothelia_vascular-VE_systemic_arterial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

THSD7A FAM124B SULF1 SMAD6

1.27e-05195334517af3e6784f02c382df6f5691945eefaa9ec4ae
ToppCell5'-Adult-LargeIntestine-Endothelial-blood_vessel_EC-Mature_venous_EC|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PLEKHG1 THSD7A FAM124B SULF1

1.32e-0519733487eda06344498dc66cac292cf89746dc90b5cf67
ToppCellParenchymal-10x5prime-Endothelial-Endothelia_vascular-VE_systemic_arterial|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

PCDH11X THSD7A SULF1 SMAD6

1.32e-05197334ad4a3b5da2190be9495382a2952991e1de9f190d
ToppCellParenchymal-NucSeq-Endothelial-Endothelia_vascular-VE_pulmonary_venous|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

PLEKHG1 FAM124B SULF1 SMAD6

1.32e-05197334b0036cf3f7e6edf8e43f16cd2f0f0e80471d2576
ToppCell5'-Adult-Appendix-Endothelial-blood_vessel_EC|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PLEKHG1 THSD7A SULF1 SMAD6

1.32e-05197334e8e879b7634a29569061d3515d180784094a31e7
ToppCellParenchymal-NucSeq-Epithelial-Epi_airway_basal|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

FGFR2 PAX9 SULF1 EPB42

1.32e-05197334107cb153ea7fc74bbd244dbb9d0499c0a8506724
ToppCelldistal-Endothelial-Artery-1|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

THSD7A FAM124B SULF1 SMAD6

1.35e-05198334f284f59f4ebe55ee132eddfaa2f5d9ecb059654f
ToppCelldistal-3-Endothelial-Artery|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

THSD7A FAM124B SULF1 SMAD6

1.37e-051993347814804f4ecc0655610e5c85f513b3976d856192
ToppCelldistal-Endothelial-Artery-3|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

THSD7A FAM124B SULF1 SMAD6

1.37e-051993348acf381087268fcf13f025e3b67e028bf1f9b77e
ToppCell3'-GW_trimst-1.5-SmallIntestine-Endothelial-blood_vessel_EC-Fetal_arterial_EC|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PLEKHG1 THSD7A FAM124B SMAD6

1.37e-05199334b15304d3d3f6c254969b54a61bee3d9f368840b2
ToppCell5'-Adult-LargeIntestine-Endothelial|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PLEKHG1 THSD7A SULF1 SMAD6

1.37e-05199334ffebd99d55d31cf51b4878b2690ed0b9b3799223
ToppCellTracheal-10x3prime_v2-Endothelial-Endothelia_vascular-VE_systemic_arterial|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

THSD7A FAM124B SULF1 RASAL1

1.37e-05199334bd43a84e84d8acb8e1008b98a235cc5bd5f43586
ToppCell5'-Adult-LargeIntestine-Endothelial-blood_vessel_EC|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PLEKHG1 THSD7A SULF1 SMAD6

1.37e-05199334258d59cf811bf1668ffbb5f18f961021f660de62
ToppCellTracheal-10x5prime-Endothelial-Endothelia_vascular-VE_systemic_arterial|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

THSD7A FAM124B SULF1 SMAD6

1.40e-052003345ec31c1be6bcc4124e1489d136570f3de33cc2e9
ToppCell5'-Adult-SmallIntestine-Endothelial|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PLEKHG1 THSD7A SULF1 SMAD6

1.40e-052003342554b77edfe3d378296b0b25625caacbfb1c0e76
ToppCellBronchial-10x5prime-Endothelial-Endothelia_vascular-VE_pulmonary_arterial|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

THSD7A FAM124B SULF1 SMAD6

1.40e-052003347547d6339f9380d031cfd2cce21ac9a12491e085
ToppCellLPS_IL1RA_TNF-Endothelial-Endothelial-Artery|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

THSD7A FAM124B SULF1 SMAD6

1.40e-0520033477ae679c35d3b9e2b620f34129f3a8d47e922c65
ToppCellControl_saline-Endothelial-Endothelial-Artery|Control_saline / Treatment groups by lineage, cell group, cell type

THSD7A FAM124B SULF1 SMAD6

1.40e-0520033465b71f1e8da5c3750fcd0a2e66d9ef3125a3f78a
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Igfbp6_Pltp|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

CASP1 THSD7A CCSER1

1.05e-0412433336dfc702a570e1a1a6dde09f38badf9023ea7287
ToppCellLPS-IL1RA-Lymphocytic_NKT-iNKT/MAIT-Erythroid|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CMKLR1 FAM124B TAF1C

1.29e-041333332ec3490cbf60152c3cece95eb566d749c9666517
ToppCellFrontal_cortex-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Syt6|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

SULF1 ICAM5 RASAL1

1.84e-041503339d5bbdca19da60e1a2121ef64ec8e1375a5dbf6d
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

PCDH11X SULF1 SMAD6

1.84e-04150333322aa0c3fc159a4b2897daac881dfc744b24ffc4
ToppCell356C-Lymphocytic-CD4_T-cell-Treg_cell_4|356C / Donor, Lineage, Cell class and subclass (all cells)

PCDH11X PAX9 FAM124B

1.95e-04153333cda759ab83a271974651fe4faa21ed4f7ecbb3ae
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell_prolif|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PCDH11X PLEKHG1 FAM124B

1.99e-04154333e51a5114f0ec38f997f5b8bbf3a7770f98595474
ToppCell356C-Lymphocytic-CD4_T-cell-Treg_cell_4|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)

PCDH11X PAX9 FAM124B

1.99e-041543331f8d127b657976656e4ec292f26d619943533b86
ToppCellfrontal_cortex-Neuronal-glutamatergic_neuron-L6_CT-L6_CT_ALM_Cpa6|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

SULF1 ICAM5 RASAL1

1.99e-0415433312cbc38bc1f7231c67e1d2d5e86e95bc12e24682
ToppCellFetal_29-31_weeks-Immune-dendritic_cell-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

TEX14 TMC6 CCSER1

2.03e-041553339f937ae48767fdcf1a944af4de0530d9c0ab441d
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_artery-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

THSD7A SULF1 SMAD6

2.11e-04157333275a4c6fef1fff8da2bdc48e3924ad05c5e5cfc8
ToppCellChildren_(3_yrs)-Epithelial-basal_cell-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

FGFR2 PAX9 LPA

2.15e-04158333d78e7e52657dc094430291fec07e9c298be9e584
ToppCell356C-Lymphocytic-CD4_T-cell-Treg_cell_4|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

PCDH11X PAX9 FAM124B

2.23e-04160333c2b5fadb4bac17fafc08831f6d3f4ff96ada7e70
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

PCDH11X SULF1 SMAD6

2.44e-04165333a74751e0ec857aa974bec04ccc747c004a8f6e01
ToppCellfacs-Marrow-B-cells-18m-Hematologic|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PAX9 TEX14 PRLR

2.44e-04165333361a605d8f833d9ec54b120480dce397da35f9c3
ToppCellEndothelial-B-Donor_04|World / lung cells shred on cell class, cell subclass, sample id

PCDH11X THSD7A SULF1

2.52e-041673336a03d16165e0b003092c39972928981abd4a75aa
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-L6_IT-L6_IT_VISp_Col23a1_Adamts2|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

SULF1 ICAM5 RASAL1

2.57e-041683333fe432267656aff81b6d92c18d1b6fc0cde73d6a
ToppCellAdult-Endothelial-endothelial_cell_of_artery-D231|Adult / Lineage, Cell type, age group and donor

THSD7A SULF1 SMAD6

2.57e-04168333aca34c51758c65925ad24110294a72b2dea6db72
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

PCDH11X SULF1 SMAD6

2.61e-04169333c7fc3a8c44f07c557b60d469717b66e2f5863d38
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D231|Adult / Lineage, Cell type, age group and donor

PLEKHG1 FGFR2 CCSER1

2.66e-04170333269dee5abca9f6aa079f116f0d8f1d198604d9d4
ToppCellsevere-Myeloid-Eosinophils|severe / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

FGFR2 THSD7A FAM124B

2.66e-04170333863f0266d5837cdbc3e09a3fe6a99dd3e6261674
ToppCellmild_COVID-19-HSPC|World / disease group, cell group and cell class (v2)

FAM124B ALK ICAM5

2.66e-0417033385c476e0bc496445e868a88849960598d97bdea2
ToppCellNS-critical-d_0-4-Lymphoid-B_cell|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

TUBGCP6 PLEKHG1 TAF1C

2.71e-04171333bd1ebd9037a740ad8c01c460d778b0973d8b56df
ToppCellControl-Epithelial_cells-Airway_basal|Control / group, cell type (main and fine annotations)

FGFR2 PAX9 SULF1

2.71e-041713333965ced4be6db14265a90673502fceee425837ca
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2-Exc_L3-5_RORB_CMAHP|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PCDH11X CCDC168 CMKLR1

2.71e-041713339d5cabd71a901a00eb16c4d151189296f1b3bf6f
ToppCellCOVID-19-Heart-T_cell|COVID-19 / Disease (COVID-19 only), tissue and cell type

IGFN1 ALK EPB42

2.71e-04171333b2e753e811a7639956994609f73efcdb62d04f82
ToppCell368C-Endothelial_cells-Endothelial-B_(Artery)|368C / Donor, Lineage, Cell class and subclass (all cells)

THSD7A FAM124B SMAD6

2.80e-0417333322200fe74e33e2beae0eed289ca8476bbc0b1b2d
ToppCell368C-Endothelial_cells-Endothelial-B_(Artery)-|368C / Donor, Lineage, Cell class and subclass (all cells)

THSD7A FAM124B SMAD6

2.80e-04173333ec88e871b49331fca59bc610a8ae58e2d5e76bc1
ToppCellwk_15-18-Endothelial-Blood_vessel_endothelial-arterial_endo|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

FAM124B SULF1 SMAD6

2.80e-041733333a9e9a09b3eeb37cbe56d650e112a8398879477f
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

FGFR2 THSD7A ICAM5

2.80e-04173333b799c06a6a5754668e789f70c0c8bc1508568575
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Myeloid-macrophage|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CASP1 PAX9 TAF1C

2.85e-0417433384f2ffe867f22d2fa79f28737a0aa42bdf2f4804
ToppCelldroplet-Liver-LIVER_HEP-30m-Lymphocytic|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCDH11X FAM124B PTPRN

2.85e-04174333ecdff386d7f0bc57c170a2c1f4deae5ba7e431b5
ToppCell368C-Endothelial_cells-Endothelial-D|368C / Donor, Lineage, Cell class and subclass (all cells)

PLEKHG1 THSD7A FAM124B

2.90e-04175333c4088b5f9fa145869cf5dd8bee7680b1c8fada42
ToppCell368C-Endothelial_cells-Endothelial-D-|368C / Donor, Lineage, Cell class and subclass (all cells)

PLEKHG1 THSD7A FAM124B

2.90e-04175333ca0d3e3a0a271cccdd3881b055fecb626712478d
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5-Exc_L4-5_RORB_LINC01474|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PCDH11X PLEKHG1 CCDC168

2.95e-04176333cd4b9211652596c42e7af318bcd464681daebb10
ToppCellE18.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

THSD7A SULF1 SMAD6

2.95e-0417633327e6b3ae41068d6cfdda3d46da7df2a27567140e
ToppCellE18.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

THSD7A SULF1 SMAD6

2.95e-04176333d6a5470af9592f34a741265f2ea9651c05c3add3
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_2-Inh_L3-6_PVALB_MFI2_(Chandelier_2)|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

THSD7A SULF1 ALK

2.99e-041773334f88ea4cfcfa8a9af5a14ab6f6be3b2aa015852e
ToppCellnucseq-Epithelial-Epithelial_Airway-Basal/Suprabasal-Basal|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

FGFR2 PAX9 SULF1

2.99e-04177333ce86dfaeb74d995a19aea62f0fb15c4c0bb854b0
ToppCellnucseq-Epithelial-Epithelial_Airway-Basal/Suprabasal|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

FGFR2 PAX9 SULF1

2.99e-04177333cbad1a23851151dbef01ea2af960e6f0944f838b
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L2-6_VIP_VIP|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PCDH11X THSD7A FAM124B

3.09e-04179333cd7f0e8f4abb2a2bac366c8910c8c5fda841dbce
ToppCelldroplet-Lung-LUNG-30m-Endothelial-Artery_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

THSD7A SULF1 SMAD6

3.09e-04179333a09647750eba9d93c5efc1db3b555fefb5eec7b5
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)|Children_(3_yrs) / Lineage, Cell type, age group and donor

FGFR2 THSD7A ICAM5

3.09e-04179333cb38b54261a7af5ee3347e64c8aa880a77ed0763
DrugBetulinic acid [472-15-1]; Down 200; 8.8uM; MCF7; HT_HG-U133A

CASP1 FGFR2 NF1 SULF1 ALK PRLR

3.65e-071983363281_DN
DrugClioquinol [130-26-7]; Up 200; 13uM; PC3; HT_HG-U133A

TEX14 SULF1 ICAM5 TAF1C RASAL1

7.54e-061903354663_UP
DrugKhellin [82-02-0]; Down 200; 15.4uM; MCF7; HT_HG-U133A

CASP1 NF1 PLAA TAF1C SMAD6

8.76e-061963354987_DN
DrugIoxaglic acid [59017-64-0]; Down 200; 3.2uM; MCF7; HT_HG-U133A

NF1 NDUFB8 PRLR TAF1C RUSC2

8.98e-061973353528_DN
Drug(1-[(4-Chlorophenyl)phenyl-methyl]-4-methylpiperazine) [1620-21-9]; Down 200; 11.8uM; MCF7; HT_HG-U133A

CASP1 FGFR2 PRLR TAF1C RASAL1

9.21e-061983356053_DN
DrugParoxetine maleate [64006-44-6]; Up 200; 1uM; PC3; HT_HG-U133A

CASP1 FGFR2 NF1 SULF1 ICAM5

9.21e-061983354556_UP
DrugBenzbromarone [3562-84-3]; Up 200; 9.4uM; MCF7; HT_HG-U133A

CASP1 NF1 PRLR TMC6 RUSC2

9.21e-061983355015_UP
Drugp-TMI

NF1 PRLR

3.04e-056332CID000017911
DrugA19413

FGFR2 PAX9 SULF1 SMAD6

3.76e-05131334CID000005307
Drugradicicol, diheterospora chlamydosporia; Up 200; 0.1uM; MCF7; HT_HG-U133A

CASP1 FGFR2 PLAA PRLR

1.26e-041793341644_UP
DrugN-(2-(3-(3,5-bis(trifluoromethyl)phenyl)ureido)ethyl)glycyrrhetinamide

FGFR2 ALK

1.33e-0412332ctd:C568507
DrugForskolin, from Coleus forskohlii; Up 200; 0.5uM; MCF7; HT_HG-U133A

CASP1 FGFR2 TEX14 PRLR

1.44e-041853347055_UP
Drug15d-PGJ2; Down 200; 10uM; MCF7; HT_HG-U133A

FGFR2 SULF1 PRLR SMAD6

1.50e-041873346948_DN
DrugSimvastatin [79902-63-9]; Up 200; 9.6uM; HL60; HT_HG-U133A

FGFR2 SULF1 ICAM5 RUSC2

1.50e-041873343002_UP
DrugEthopropazine hydrochloride [1094-08-2]; Up 200; 11.4uM; MCF7; HT_HG-U133A

NF1 NDUFB8 PRLR TMC6

1.62e-041913345296_UP
DrugDoxycycline hydrochloride [10592-13-9]; Up 200; 8.4uM; MCF7; HT_HG-U133A

FGFR2 PRLR TAF1C RUSC2

1.62e-041913347195_UP
Drug17-AAG; Up 200; 1uM; MCF7; HT_HG-U133A

FGFR2 NF1 PLAA RUSC2

1.62e-041913345953_UP
DrugPinacidil [85371-64-8]; Down 200; 16.4uM; MCF7; HT_HG-U133A

CASP1 NF1 PLAA NDUFB8

1.62e-041913345456_DN
DrugMethantheline bromide [53-46-3]; Down 200; 9.6uM; MCF7; HT_HG-U133A

CASP1 FGFR2 PLAA DENND4C

1.66e-041923346254_DN
DrugRescinnamin [24815-24-5]; Down 200; 6.4uM; MCF7; HT_HG-U133A

CASP1 FGFR2 SULF1 PRLR

1.66e-041923342785_DN
DrugHexetidine [141-94-6]; Down 200; 11.8uM; MCF7; HT_HG-U133A

FGFR2 NF1 PRLR RUSC2

1.66e-041923343318_DN
DrugICI182,780; Up 200; 1uM; MCF7; HT_HG-U133A

FGFR2 NF1 PRLR RASAL1

1.69e-041933347490_UP
DrugTolazamide [1156-19-0]; Up 200; 12.8uM; MCF7; HT_HG-U133A

FGFR2 NF1 NDUFB8 TMC6

1.69e-041933342842_UP
Drug5155877; Down 200; 10uM; MCF7; HT_HG-U133A

CASP1 FGFR2 NF1 TMC6

1.69e-041933346574_DN
DrugBromperidol [10457-90-6]; Up 200; 9.6uM; MCF7; HT_HG-U133A

NF1 THSD7A RASAL1 RUSC2

1.69e-041933342872_UP
DrugDiphenidol hydrochloride [3254-89-5]; Down 200; 11.6uM; MCF7; HT_HG-U133A

FGFR2 NF1 SULF1 PRLR

1.69e-041933347447_DN
DrugAdamantamine fumarate [80789-67-9]; Down 200; 9.6uM; MCF7; HT_HG-U133A

FGFR2 PLAA NDUFB8 PRLR

1.72e-041943343280_DN
Drugtroglitazone; Up 200; 10uM; MCF7; HT_HG-U133A

CASP1 NDUFB8 ALK TAF1C

1.72e-041943345229_UP
DrugTacrine hydrochloride hydrate [1684-40-8]; Down 200; 15.8uM; MCF7; HT_HG-U133A

PLAA SULF1 TAF1C TMC6

1.72e-041943345297_DN
DrugFelodipine [72509-76-3]; Down 200; 10.4uM; PC3; HT_HG-U133A

CASP1 FGFR2 NF1 SULF1

1.72e-041943346695_DN
DrugEstropipate [7280-37-7]; Down 200; 9.2uM; MCF7; HT_HG-U133A

CASP1 FGFR2 TMC6 SMAD6

1.72e-041943346068_DN
DrugDecamethonium bromide [541-22-0]; Down 200; 9.6uM; MCF7; HT_HG-U133A

CASP1 FGFR2 PAX9 NF1

1.72e-041943344174_DN
DrugCefoperazone dihydrate; Down 200; 5.8uM; MCF7; HT_HG-U133A

NF1 NDUFB8 PRLR RASAL1

1.76e-041953345424_DN
DrugAsiaticoside [16830-15-2]; Down 200; 4.2uM; MCF7; HT_HG-U133A

FGFR2 NF1 PRLR TAF1C

1.76e-041953343504_DN
DrugIsoetharine mesylate salt [7279-75-6]; Down 200; 12uM; MCF7; HT_HG-U133A

CASP1 FGFR2 NF1 PRLR

1.76e-041953343451_DN
DrugTiaprofenic acid [33005-95-7]; Down 200; 15.4uM; MCF7; HT_HG-U133A

CASP1 NF1 PRLR RASAL1

1.76e-041953342852_DN
DrugMethoxy-8-psoralen [298-81-7]; Down 200; 18.6uM; PC3; HT_HG-U133A

CASP1 NF1 ALK RUSC2

1.76e-041953346661_DN
DrugIvermectin [70288-86-7]; Down 200; 4.6uM; PC3; HT_HG-U133A

CASP1 NDUFB8 SMAD6 RUSC2

1.79e-041963342051_DN
DrugFluvoxamine maleate [61718-82-9]; Up 200; 9.2uM; MCF7; HT_HG-U133A

TEX14 NF1 ICAM5 TAF1C

1.79e-041963344114_UP
DrugDyclonine hydrochloride [536-43-6]; Down 200; 12.2uM; MCF7; HT_HG-U133A

FGFR2 NF1 PRLR DENND4C

1.79e-041963347022_DN
Drug(-)-Cinchonidine [485-71-2]; Down 200; 13.6uM; PC3; HT_HG-U133A

CASP1 NF1 TMC6 RUSC2

1.79e-041963345833_DN
DrugRetrorsine [480-54-6]; Up 200; 11.4uM; PC3; HT_HG-U133A

FGFR2 NF1 RASAL1 EPB42

1.79e-041963346601_UP
DrugIndapamide [26807-65-8]; Down 200; 10.6uM; MCF7; HT_HG-U133A

CASP1 PAX9 NF1 RUSC2

1.79e-041963343970_DN
DrugMeclofenamic acid sodium salt monohydrate [6385-02-0]; Down 200; 11.8uM; MCF7; HT_HG-U133A

NF1 NDUFB8 SULF1 TMC6

1.79e-041963342291_DN
DrugThiethylperazine malate [52239-63-1]; Up 200; 6uM; MCF7; HT_HG-U133A

FGFR2 NF1 PRLR RASAL1

1.79e-041963346232_UP
Drugfluphenazine dihydrochloride; Up 200; 10uM; MCF7; HG-U133A

CASP1 CMKLR1 ALK TMC6

1.79e-04196334490_UP
DrugMethotrimeprazine maleat salt [7104-38-3]; Down 200; 9uM; MCF7; HT_HG-U133A

NF1 TMC6 SMAD6 RUSC2

1.79e-041963344723_DN
Drugbeta- Belladonnine dichloroethylate [191355-47-2]; Down 200; 6uM; MCF7; HT_HG-U133A

NF1 NDUFB8 SULF1 TAF1C

1.79e-041963344984_DN
DrugProcarbazine hydrochloride [366-70-1]; Down 200; 15.6uM; MCF7; HT_HG-U133A

FGFR2 NF1 PLAA RUSC2

1.79e-041963343533_DN
DrugCortisone [53-06-5]; Up 200; 11uM; MCF7; HT_HG-U133A

NF1 TAF1C RASAL1 RUSC2

1.83e-041973347458_UP
DrugMimosine [500-44-7]; Down 200; 20.2uM; MCF7; HT_HG-U133A

CASP1 NF1 PLAA PRLR

1.83e-041973342638_DN
DrugRapamycin; Up 200; 0.1uM; MCF7; HT_HG-U133A

CASP1 NF1 ALK TAF1C

1.83e-041973346940_UP
DrugSulfaphenazole [526-08-9]; Down 200; 12.8uM; MCF7; HT_HG-U133A

CASP1 NF1 NDUFB8 TMC6

1.83e-041973345507_DN
DrugAscorbic acid [50-81-7]; Up 200; 22.4uM; PC3; HT_HG-U133A

NF1 SULF1 ALK TMC6

1.83e-041973346306_UP
DrugFluoxetine hydrochloride [59333-67-4]; Down 200; 11.6uM; MCF7; HT_HG-U133A

NF1 NDUFB8 SULF1 RUSC2

1.83e-041973343314_DN
DrugMidecamycin [35457-80-8]; Down 200; 5uM; MCF7; HT_HG-U133A

CASP1 NF1 PRLR TMC6

1.83e-041973341526_DN
DrugMeclocycline sulfosalicylate [73816-42-9]; Down 200; 5.8uM; MCF7; HT_HG-U133A

NF1 SULF1 PRLR TMC6

1.83e-041973343277_DN
Drugestradiol; Up 200; 0.01uM; PC3; HT_HG-U133A

CASP1 NF1 PLAA ALK

1.83e-041973345960_UP
DrugIdazoxan hydrochloride [79944-56-2]; Up 200; 16.6uM; PC3; HT_HG-U133A

TEX14 NF1 ALK LPA

1.83e-041973346747_UP
DrugCyclosporin A [59865-13-3]; Down 200; 3.4uM; MCF7; HT_HG-U133A

FGFR2 NF1 ALK SMAD6

1.83e-041973343267_DN
DrugLymecycline [992-21-2]; Down 200; 6.6uM; MCF7; HT_HG-U133A

CASP1 FGFR2 PLAA PRLR

1.83e-041973345994_DN
DrugSuramin sodium salt; Up 200; 10uM; MCF7; HT_HG-U133A

CASP1 NF1 TAF1C RASAL1

1.86e-041983347524_UP
DrugHydroxytacrine maleate (R,S) [118909-22-1]; Down 200; 12.2uM; MCF7; HT_HG-U133A

NF1 PRLR SMAD6 RUSC2

1.86e-041983343292_DN
Drug15(S)-15-methyl Prostaglandin E2; Down 200; 10uM; MCF7; HT_HG-U133A

CASP1 PRLR TMC6 SMAD6

1.86e-041983347521_DN
DrugLumicolchicine gamma [6901-14-0]; Up 200; 10uM; PC3; HT_HG-U133A

TEX14 NF1 SULF1 TAF1C

1.86e-041983344195_UP
DrugHexylcaine hydrochloride [532-76-3]; Down 200; 13.4uM; PC3; HT_HG-U133A

CASP1 NF1 NDUFB8 RUSC2

1.86e-041983345768_DN
DrugPyrantel tartrate [33401-94-4]; Down 200; 11.2uM; PC3; HT_HG-U133A

NDUFB8 TAF1C TMC6 RUSC2

1.86e-041983342097_DN
DrugOleandomycin phosphate [7060-74-4]; Up 200; 5uM; PC3; HT_HG-U133A

CASP1 NF1 SULF1 EPB42

1.86e-041983344615_UP
DrugNitrendipine [39562-70-4]; Down 200; 11uM; MCF7; HT_HG-U133A

NF1 PLAA SULF1 PRLR

1.86e-041983346464_DN
Drug(+,-)-Octopamine hydrochloride [770-05-8]; Down 200; 21uM; MCF7; HT_HG-U133A

NF1 PRLR TMC6 SMAD6

1.86e-041983345469_DN
DrugFurosemide [54-31-9]; Down 200; 12uM; MCF7; HT_HG-U133A

FGFR2 PRLR RASAL1 TMC6

1.86e-041983346841_DN
DrugTrimethobenzamide hydrochloride [554-92-7]; Down 200; 9.4uM; MCF7; HT_HG-U133A

NF1 SULF1 PRLR SMAD6

1.90e-041993341502_DN
DrugParoxetine maleate [64006-44-6]; Up 200; 1uM; PC3; HT_HG-U133A

FGFR2 NF1 SULF1 ICAM5

1.90e-041993343821_UP
DrugPhenethicillin potassium salt [132-93-4]; Up 200; 10uM; MCF7; HT_HG-U133A

TEX14 NF1 THSD7A ALK

1.90e-041993346105_UP
DrugKetoconazole [65277-42-1]; Up 200; 7.6uM; MCF7; HT_HG-U133A

CASP1 NF1 ALK TMC6

1.90e-041993342640_UP
DrugPHA-00851261E [724719-49-7]; Up 200; 10uM; PC3; HT_HG-U133A

CASP1 FGFR2 CMKLR1 NF1

1.90e-041993344330_UP
DrugWY-14643; Up 200; 100uM; PC3; HG-U133A

CMKLR1 TAF1C RASAL1 SMAD6

1.94e-04200334481_UP
DrugAustricine [10180-88-8]; Down 200; 14.2uM; MCF7; HT_HG-U133A

FGFR2 PRLR TAF1C SMAD6

1.94e-042003344797_DN
DrugOmeprazole [73590-58-6]; Up 200; 11.6uM; PC3; HT_HG-U133A

CASP1 FGFR2 NF1 SULF1

1.94e-042003346606_UP
DrugAa 31

CASP1 CMKLR1

2.73e-0417332CID000191056
Drugestradiol-17 beta-benzoate

FGFR2 PRLR

5.51e-0424332ctd:C010452
Drug2-methylbutyric acid 4-((1,3)dioxan-5-ylmethoxyimino)-8-(2-(4-hydroxy-6-oxo-tetrahydropyran-2-yl)ethyl -7-methyl-6-oxo-1,2,3,4,6,7,8,8a-octahydronaphthyl)heptanoate

TUBGCP6 PLAA

7.52e-0428332ctd:C518576
DrugHeparitin Sulfate

FGFR2 SULF1

8.07e-0429332ctd:D006497
DrugDB04683

PTPRN NDUFB8

9.23e-0431332CID005288113
DrugSuramin

CASP1 FGFR2

9.23e-0431332ctd:D013498
Drugpyrachlostrobin

PCDH11X FGFR2 SULF1 ICAM5 DENND4C SMAD6

9.75e-04811336ctd:C513428
Drugformylglycine

SULF1 ALK

1.05e-0333332CID000075606
Drugbeta-pyridylcarbinol

LPAL2 LPA

1.39e-0338332CID000007510
Druglynestrenol

LPAL2 LPA

1.39e-0338332CID000005857
DrugThimerosal

FGFR2 NF1 FAM124B PRLR TMC6 RUSC2 CCSER1

1.41e-031199337ctd:D013849
Diseaselipoprotein A measurement, apolipoprotein A 1 measurement

LPAL2 LPA

2.24e-057312EFO_0004614, EFO_0006925
Diseasecraniosynostosis (is_implicated_in)

FGFR2 SMAD6

7.00e-0512312DOID:2340 (is_implicated_in)
Diseasetriglycerides to total lipids in chylomicrons and extremely large VLDL percentage

LPAL2 LPA

1.11e-0415312EFO_0022328
DiseaseTrigonocephaly

FGFR2 SMAD6

1.27e-0416312C0265535
DiseaseScaphycephaly

FGFR2 SMAD6

1.27e-0416312C0265534
DiseaseSynostotic Posterior Plagiocephaly

FGFR2 SMAD6

1.27e-0416312C1833340
DiseaseSynostotic Anterior Plagiocephaly

FGFR2 SMAD6

1.27e-0416312C2931150
DiseaseMetopic synostosis

FGFR2 SMAD6

1.27e-0416312C1860819
DiseaseCraniosynostosis, Type 1

FGFR2 SMAD6

1.27e-0416312C4551902
DiseaseAcrocephaly

FGFR2 SMAD6

1.27e-0416312C0030044
Diseasecholesterol to total lipids in chylomicrons and extremely large VLDL percentage

LPAL2 LPA

1.44e-0417312EFO_0022232
DiseaseBrachycephaly

FGFR2 SMAD6

1.44e-0417312C0221356
DiseaseCraniosynostosis

FGFR2 SMAD6

2.01e-0420312C0010278
Diseasefree cholesterol to total lipids in chylomicrons and extremely large VLDL percentage

LPAL2 LPA

2.22e-0421312EFO_0022277
Diseasecholesteryl esters to total lipids in chylomicrons and extremely large VLDL percentage

LPAL2 LPA

2.22e-0421312EFO_0022246
Diseasedocosahexaenoic acid to total fatty acids percentage

LPAL2 LPA

2.22e-0421312EFO_0022262
DiseaseOvarian Serous Adenocarcinoma

FGFR2 ALK

2.67e-0423312C1335177
Diseaseidiopathic pulmonary fibrosis (is_marker_for)

FGFR2 SMAD6

2.67e-0423312DOID:0050156 (is_marker_for)
DiseaseHVA measurement

DENND4C CCSER1

3.42e-0426312EFO_0005131
Diseasehypertension, COVID-19

PLEKHG1 ICAM5

3.69e-0427312EFO_0000537, MONDO_0100096
Diseasechylomicron measurement, very low density lipoprotein cholesterol measurement, cholesteryl esters:total lipids ratio

LPAL2 LPA

5.87e-0434312EFO_0008317, EFO_0008596, EFO_0020944
Diseasechylomicron measurement, triglycerides:total lipids ratio, very low density lipoprotein cholesterol measurement

LPAL2 LPA

5.87e-0434312EFO_0008317, EFO_0008596, EFO_0020947
Diseasedegree of unsaturation measurement

LPAL2 LPA

7.73e-0439312EFO_0022261
Diseaseaspirin use measurement

LPAL2 LPA

7.73e-0439312EFO_0007013
DiseaseCutaneous Melanoma

NF1 ALK

8.54e-0441312C0151779
Diseaseaortic stenosis, aortic valve calcification

LPA DENND4C

8.96e-0442312EFO_0000266, EFO_0005239
Diseasecholesteryl esters to total lipids in small LDL percentage

LPAL2 LPA

8.96e-0442312EFO_0022255
Diseasecholesteryl esters to total lipids in small HDL percentage

LPAL2 LPA

9.39e-0443312EFO_0022254
Diseasesaturated fatty acids measurement

LPAL2 LPA

1.03e-0345312EFO_0022304
Diseasecholesterol to total lipids in large VLDL percentage

LPAL2 LPA

1.03e-0345312EFO_0022236

Protein segments in the cluster

PeptideGeneStartEntry
FQTSTECWMTRPALP

EPB42

326

P16452
HCPASEEPSTESWMA

CAMTA1

1181

Q9Y6Y1
CSHISRMPNSPSADW

CCSER1

591

Q9C0I3
SFSKSPEWQMCHSIP

RASAL1

601

O95294
MRDCWHAVPSQRPTF

FGFR2

736

P21802
SHSSTPSWCEEPAQA

PTPRN

671

Q16849
VAMPRTWPSSHSVTD

PAX9

186

P55771
PEMDESTCPSHQTWL

ICAM5

666

Q9UMF0
SVSDMAPTRPRWNTH

TUBGCP6

1201

Q96RT7
RVDTSPTPVSWHVMC

NDUFB8

116

O95169
ACWMPASLDHSSSSQ

PCDH11X

1151

Q9BZA7
NPCMPISSTRWQTQD

FAM124B

221

Q9H5Z6
CSSTPDNVSWRHPTM

CASP1

331

P29466
HLPDSRTCMSESTWN

DENND4C

1106

Q5VZ89
VTGRTCQAWSSMTPH

LPA

386

P08519
TGRTCQAWSSMTPHS

LPA

501

P08519
QAWSSMTPHSHSRTP

LPA

506

P08519
AWSSMTPHSHSRTPE

LPA

621

P08519
VTGRTCQAWSSMTPH

LPA

956

P08519
TGRTCQAWSSMTPHQ

LPA

1071

P08519
QAWSSMTPHQHSRTP

LPA

1076

P08519
PACSHVPMWSARLLT

CRIPAK

341

Q8N1N5
MSCAVQGSPRPHVTW

IGFN1

1176

Q86VF2
VTRSFLPPSWHMESS

CCDC168

4591

Q8NDH2
PWSTQVCQGPHSSEM

RUSC2

616

Q8N2Y8
SASPSCHWDSTRMSV

TEX14

896

Q8IWB6
MSPDATKPSHWCSVA

SMAD6

321

O43541
HVGPWSTCSMPHSRQ

THSD7A

256

Q9UPZ6
AWSSMTPHQHSRTPE

LPAL2

51

Q16609
DTQPDCHAPTASWTS

TAF1C

616

Q15572
PWMRSSSEHCTLAVS

ALK

336

Q9UM73
STPGSSSWPTHSQMD

CMKLR1

196

Q99788
WAPDSPNRSFTEMHC

PLAA

46

Q9Y263
PETTHTWDPQCISME

PRLR

386

P16471
TCLSPTPTLEQHLMW

NF1

2061

P21359
MRASPCISQPAASWH

TP53TG3

1

Q9ULZ0
CQAPRRPWLASHMST

TMC6

636

Q7Z403
TSSRPCSWHMGQMES

PLEKHG1

581

Q9ULL1
NCSSPSWQAMHEPRT

SULF1

111

Q8IWU6
AHQRGSSSWMCPSDP

LRRC73

281

Q5JTD7