Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionfibroblast growth factor receptor activity

FGFR1 FGFR2

1.63e-055262GO:0005007
GeneOntologyMolecularFunctionfibroblast growth factor binding

FGFR1 FGFR2

5.61e-0427262GO:0017134
GeneOntologyMolecularFunctionprotein tyrosine kinase activity

FGFR1 FGFR2 CSK

8.63e-04145263GO:0004713
GeneOntologyMolecularFunctionpalmitoyltransferase activity

ZDHHC17 HHAT

1.06e-0337262GO:0016409
GeneOntologyBiologicalProcessfibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development

FGFR1 FGFR2

1.53e-062262GO:0035607
GeneOntologyBiologicalProcessventricular zone neuroblast division

FGFR1 FGFR2

4.58e-063262GO:0021847
GeneOntologyBiologicalProcessorbitofrontal cortex development

FGFR1 FGFR2

4.58e-063262GO:0021769
GeneOntologyBiologicalProcessforebrain ventricular zone progenitor cell division

FGFR1 FGFR2

2.28e-056262GO:0021869
GeneOntologyBiologicalProcessforebrain neuroblast division

FGFR1 FGFR2

3.20e-057262GO:0021873
GeneOntologyBiologicalProcesslung-associated mesenchyme development

FGFR1 FGFR2

6.83e-0510262GO:0060484
GeneOntologyBiologicalProcesspositive regulation of phospholipase activity

FGFR1 FGFR2

1.38e-0414262GO:0010518
GeneOntologyBiologicalProcessneuroblast division

FGFR1 FGFR2

1.81e-0416262GO:0055057
GeneOntologyBiologicalProcessvasculogenesis involved in coronary vascular morphogenesis

FGFR1 FGFR2

2.31e-0418262GO:0060979
GeneOntologyBiologicalProcessregulation of phospholipase activity

FGFR1 FGFR2

3.48e-0422262GO:0010517
GeneOntologyBiologicalProcessvasculogenesis

ASB4 FGFR1 FGFR2

4.31e-04118263GO:0001570
GeneOntologyBiologicalProcesspositive regulation of lipase activity

FGFR1 FGFR2

4.50e-0425262GO:0060193
GeneOntologyBiologicalProcessbranching involved in salivary gland morphogenesis

FGFR1 FGFR2

5.66e-0428262GO:0060445
GeneOntologyBiologicalProcessprotein palmitoylation

ZDHHC17 HHAT

7.88e-0433262GO:0018345
GeneOntologyBiologicalProcesscoronary vasculature morphogenesis

FGFR1 FGFR2

8.36e-0434262GO:0060977
GeneOntologyBiologicalProcessmesodermal cell differentiation

FGFR1 FGFR2

8.86e-0435262GO:0048333
GeneOntologyBiologicalProcesspositive regulation of mesenchymal cell proliferation

FGFR1 FGFR2

9.38e-0436262GO:0002053
GeneOntologyBiologicalProcesscell proliferation in forebrain

FGFR1 FGFR2

1.04e-0338262GO:0021846
GeneOntologyBiologicalProcesspositive regulation of cardiac muscle cell proliferation

FGFR1 FGFR2

1.04e-0338262GO:0060045
GeneOntologyBiologicalProcesssalivary gland morphogenesis

FGFR1 FGFR2

1.04e-0338262GO:0007435
GeneOntologyBiologicalProcessspecification of animal organ identity

FGFR1 FGFR2

1.22e-0341262GO:0010092
GeneOntologyBiologicalProcessregulation of lipase activity

FGFR1 FGFR2

1.22e-0341262GO:0060191
HumanPhenoBroad proximal phalanx of the hallux

FGFR1 FGFR2

3.47e-062102HP:0010086
HumanPhenoCalcaneonavicular fusion

FGFR1 FGFR2

3.47e-062102HP:0008122
HumanPheno3-4 toe cutaneous syndactyly

FGFR1 FGFR2

3.47e-062102HP:6000648
HumanPhenoBroad middle phalanges of the toes

FGFR1 FGFR2

3.47e-062102HP:0010195
HumanPhenoTracheal cartilaginous sleeve

FGFR1 FGFR2

3.47e-062102HP:0005347
HumanPhenoBroad distal phalanx of the hallux

FGFR1 FGFR2

1.04e-053102HP:0010077
HumanPhenoAnomalous tracheal cartilage

FGFR1 FGFR2

2.08e-054102HP:0004468
HumanPhenoShort middle phalanx of toe

FGFR1 FGFR2

3.46e-055102HP:0003795
HumanPhenoBroad distal phalanx of the toes

FGFR1 FGFR2

3.46e-055102HP:0010186
HumanPhenoShort first metatarsal

FGFR1 FGFR2

3.46e-055102HP:0010105
HumanPhenoHallux varus

FGFR1 FGFR2

3.46e-055102HP:0008080
HumanPhenoAbnormality of the incisor

FGFR1 FGFR2 CNOT1 RIC1

3.64e-05108104HP:0000676
HumanPhenoConical incisor

FGFR1 FGFR2 RIC1

4.80e-0539103HP:0011065
HumanPhenoBroad first metatarsal

FGFR1 FGFR2

5.18e-056102HP:0010068
HumanPhenoAbnormal morphology of the proximal phalanx of the hallux

FGFR1 FGFR2

5.18e-056102HP:0010052
HumanPhenoBroad proximal phalanx of toe

FGFR1 FGFR2

5.18e-056102HP:0010204
HumanPhenoShortening of all middle phalanges of the fingers

FGFR1 FGFR2

7.25e-057102HP:0006110
HumanPhenoAplasia/hypoplasia of the 1st metatarsal

FGFR1 FGFR2

9.65e-058102HP:0010067
HumanPhenoElbow ankylosis

FGFR1 FGFR2

9.65e-058102HP:0003070
HumanPhenoShort phalanx of hallux

FGFR1 FGFR2

9.65e-058102HP:0010111
HumanPhenoAplasia/hypoplasia of proximal toe phalanx

FGFR1 FGFR2

9.65e-058102HP:0010203
HumanPhenoCloverleaf skull

FGFR1 FGFR2

9.65e-058102HP:0002676
HumanPhenoBrachyturricephaly

FGFR1 FGFR2

1.24e-049102HP:0000244
HumanPhenoSemilobar holoprosencephaly

FGFR1 CNOT1

1.24e-049102HP:0002507
HumanPhenoPalmoplantar cutis laxa

ZNF469 FGFR2

1.24e-049102HP:0007517
HumanPhenoConical tooth

FGFR1 FGFR2 RIC1

1.36e-0455103HP:0000698
HumanPhenoBroad long bones

SIAH1 FGFR1 FGFR2 HHAT

1.58e-04157104HP:0005622
HumanPhenoAplasia/Hypoplasia of the phalanges of the hand

SIAH1 FGFR1 FGFR2 CNOT1 HHAT

1.81e-04319105HP:0009767
HumanPhenoHumeroradial synostosis

FGFR1 FGFR2

1.89e-0411102HP:0003041
HumanPhenoAbnormality of the middle phalanges of the toes

FGFR1 FGFR2

1.89e-0411102HP:0010183
HumanPhenoSynostosis involving the elbow

FGFR1 FGFR2

1.89e-0411102HP:0003938
HumanPhenoAbnormal incisor morphology

FGFR1 FGFR2 RIC1

1.94e-0462103HP:0011063
HumanPhenoAbnormal number of incisors

FGFR1 CNOT1 RIC1

2.03e-0463103HP:0011064
HumanPhenoAbnormality of the distal phalanx of the hallux

FGFR1 FGFR2

2.27e-0412102HP:0010053
HumanPhenoHypoplasia of the phalanges of the toes

FGFR1 FGFR2

2.27e-0412102HP:0010746
HumanPhenoCamptodactyly

ZNF469 FGFR1 FGFR2 TDO2 RIC1

2.66e-04346105HP:0012385
HumanPhenoAbsent septum pellucidum

FGFR1 FGFR2 CNOT1

2.67e-0469103HP:0001331
HumanPhenoAbnormality of the first metatarsal bone

FGFR1 FGFR2

2.67e-0413102HP:0010054
HumanPhenoAplasia/Hypoplasia of the phalanges of the hallux

FGFR1 FGFR2

2.67e-0413102HP:0010058
HumanPhenoBicoronal synostosis

FGFR1 FGFR2

2.67e-0413102HP:0011318
HumanPhenoBroad metatarsal

FGFR1 FGFR2

2.67e-0413102HP:0001783
HumanPhenoExcessive wrinkling of palmar skin

ZNF469 FGFR2

2.67e-0413102HP:0007605
HumanPhenoAbnormality of toe proximal phalanx

FGFR1 FGFR2

3.12e-0414102HP:0010184
HumanPhenoFlexion contracture of digit

ZNF469 FGFR1 FGFR2 TDO2 RIC1

3.30e-04362105HP:0030044
HumanPhenoFlared metaphysis

SIAH1 FGFR1 FGFR2 HHAT

3.37e-04191104HP:0003015
HumanPhenoBroad hallux

SIAH1 FGFR1 FGFR2

3.55e-0476103HP:0010055
HumanPhenoMicrotia

SIAH1 FGFR2 CNOT1 RIC1

3.65e-04195104HP:0008551
HumanPhenoEpicanthus

SIAH1 ZNF469 FGFR1 FGFR2 CNOT1 RIC1

4.10e-04614106HP:0000286
HumanPhenoVisceral angiomatosis

FGFR1 FGFR2

4.10e-0416102HP:0100761
HumanPhenoAbnormality of thumb phalanx

SIAH1 FGFR1 FGFR2 CNOT1

4.42e-04205104HP:0009602
HumanPhenoAplasia/Hypoplasia of the external ear

SIAH1 FGFR2 CNOT1 RIC1

4.85e-04210104HP:0008772
HumanPhenoAbnormal hallux morphology

SIAH1 ZNF469 FGFR1 FGFR2

5.03e-04212104HP:0001844
HumanPhenoTriangular shaped phalanges of the hand

SIAH1 FGFR1 FGFR2 CNOT1

5.21e-04214104HP:0009774
HumanPhenoBroad toe

SIAH1 FGFR1 FGFR2

5.30e-0487103HP:0001837
HumanPhenoDeviation of the hallux

ZNF469 FGFR1 FGFR2

5.48e-0488103HP:0010051
HumanPhenoAplasia/Hypoplasia of the ear

SIAH1 FGFR2 CNOT1 RIC1

5.69e-04219104HP:0008771
HumanPhenoAbnormal thumb morphology

SIAH1 FGFR1 FGFR2 TDO2 CNOT1

5.78e-04408105HP:0001172
HumanPhenoAnkylosis

FGFR1 FGFR2

5.83e-0419102HP:0031013
HumanPhenoBroad thumb

SIAH1 FGFR1 FGFR2

5.85e-0490103HP:0011304
HumanPhenoAbnormality of skull ossification

FGFR1 FGFR2 HHAT

6.65e-0494103HP:0002703
HumanPhenoMetaphyseal widening

SIAH1 FGFR1 FGFR2 HHAT

7.09e-04232104HP:0003016
HumanPhenoHemangiomatosis

FGFR1 FGFR2

7.14e-0421102HP:0007461
HumanPhenoBrachydactyly (hand)

SIAH1 FGFR1 FGFR2 CNOT1 HHAT

7.38e-04430105HP:0100667
HumanPhenoBroad hallux phalanx

FGFR1 FGFR2

9.36e-0424102HP:0010059
HumanPhenoBronchomalacia

FGFR1 FGFR2

9.36e-0424102HP:0002780
HumanPhenoOcular anterior segment dysgenesis

ZNF469 FGFR1 FGFR2 RIC1 HHAT

9.69e-04456105HP:0007700
HumanPhenoLobar holoprosencephaly

FGFR1 CNOT1

1.10e-0326102HP:0006870
HumanPhenoTarsal synostosis

FGFR1 FGFR2

1.10e-0326102HP:0008368
HumanPhenoPeg-shaped maxillary lateral incisors

FGFR1 RIC1

1.10e-0326102HP:0006342
HumanPhenoAbnormal septum pellucidum morphology

FGFR1 FGFR2 CNOT1

1.11e-03112103HP:0007375
HumanPhenoAbnormal finger phalanx morphology

SIAH1 FGFR1 FGFR2 TDO2 CNOT1 HHAT

1.13e-03738106HP:0005918
HumanPhenoSingle central incisor

FGFR1 CNOT1

1.19e-0327102HP:0001573
HumanPhenoSolitary median maxillary central incisor

FGFR1 CNOT1

1.19e-0327102HP:0006315
HumanPhenoAbnormal clavicle morphology

FGFR1 FGFR2 HHAT

1.23e-03116103HP:0000889
HumanPhenoAqueductal stenosis

FGFR1 FGFR2

1.28e-0328102HP:0002410
HumanPhenoAgenesis of lateral incisor

FGFR1 RIC1

1.28e-0328102HP:0200153
HumanPhenoChoanal stenosis

FGFR1 FGFR2

1.28e-0328102HP:0000452
HumanPhenoDeviation of toes

ZNF469 FGFR1 FGFR2

1.29e-03118103HP:0100498
HumanPhenoAbnormality of the distal phalanges of the toes

FGFR1 FGFR2

1.37e-0329102HP:0010182
HumanPhenoAbnormal anterior chamber morphology

ZNF469 FGFR1 FGFR2 RIC1 HHAT

1.48e-03500105HP:0000593
HumanPhenoAbnormal soft palate morphology

SIAH1 FGFR1 FGFR2 RIC1

1.62e-03289104HP:0100736
HumanPhenoSynostosis involving bones of the feet

FGFR1 FGFR2

1.67e-0332102HP:0009140
HumanPhenoSynostosis involving bones of the lower limbs

FGFR1 FGFR2

1.67e-0332102HP:0009138
HumanPhenoCoronal craniosynostosis

FGFR1 FGFR2

1.67e-0332102HP:0004440
HumanPhenoHypoplasia of the maxilla

FGFR1 FGFR2 RIC1

1.71e-03130103HP:0000327
HumanPhenoCutis laxa

ZNF469 FGFR2 NDUFB10

1.75e-03131103HP:0000973
HumanPhenoBell-shaped thorax

FGFR2 HHAT

1.77e-0333102HP:0001591
HumanPhenoAplasia/Hypoplasia of the maxilla

FGFR1 FGFR2 RIC1

1.83e-03133103HP:0009117
HumanPhenoEsophageal atresia

FGFR1 FGFR2

1.88e-0334102HP:0002032
HumanPhenoRedundant neck skin

FGFR2 NDUFB10

1.88e-0334102HP:0005989
HumanPhenoRedundant skin folds

FGFR2 NDUFB10

1.88e-0334102HP:0007391
HumanPhenoStrabismus

SIAH1 FGFR1 FGFR2 TDO2 NDUFB10 RIC1 HHAT

1.93e-031159107HP:0000486
MousePhenoenlarged allantois

FGFR1 FGFR2 CSK

8.08e-0715183MP:0004556
MousePhenopremature facial suture closure

FGFR1 FGFR2

1.57e-062182MP:0030390
MousePhenoabnormal facial suture morphology

FGFR1 FGFR2

9.38e-064182MP:0030230
MousePhenopremature coronal suture closure

FGFR1 FGFR2

2.34e-056182MP:0030350
MousePhenoarrest of tooth development

FGFR2 HHAT

3.28e-057182MP:0000118
MousePhenoabnormal ear development

FGFR1 FGFR2 CSK

7.45e-0565183MP:0003938
MousePhenoabsent limb buds

FGFR1 FGFR2

1.21e-0413182MP:0004573
MousePhenopremature cranial suture closure

FGFR1 FGFR2

1.41e-0414182MP:0000081
MousePhenopremature intramembranous bone ossification

FGFR1 FGFR2

1.41e-0414182MP:0003418
MousePhenopremature craniofacial suture closure

FGFR1 FGFR2

1.41e-0414182MP:0030435
MousePhenoabsent visceral yolk sac blood islands

FGFR1 CSK

1.41e-0414182MP:0001721
MousePhenoabnormal osteoblast proliferation

FGFR1 FGFR2

1.63e-0415182MP:0030437
MousePhenomacrodontia

FGFR1 FGFR2

1.86e-0416182MP:0030091
MousePhenolong incisors

FGFR1 FGFR2

1.86e-0416182MP:0004831
MousePhenomidface hypoplasia

FGFR1 FGFR2

2.11e-0417182MP:0012085
MousePhenoface hypoplasia

FGFR1 FGFR2

2.64e-0419182MP:0030065
MousePhenoabnormal otic vesicle development

FGFR2 CSK

2.93e-0420182MP:0006030
MousePhenoabnormal allantois morphology

FGFR1 FGFR2 CSK

3.74e-04112183MP:0001726
MousePhenoabnormal primitive endoderm morphology

FGFR1 FGFR2

4.25e-0424182MP:0011183
MousePhenoabnormal tongue morphology

FGFR1 FGFR2 HHAT

4.36e-04118183MP:0000762
MousePhenoabnormal nasal cartilage morphology

FGFR2 HHAT

4.62e-0425182MP:0031449
MousePhenoabnormal palatal shelf morphology

FGFR1 FGFR2 HHAT

4.69e-04121183MP:0031460
MousePhenoabnormal basicranium morphology

FGFR1 FGFR2 HHAT

4.93e-04123183MP:0010029
MousePhenopremature bone ossification

FGFR1 FGFR2

5.00e-0426182MP:0003416
MousePhenoabnormal secondary palate development

FGFR1 FGFR2 HHAT

5.04e-04124183MP:0009655
MousePhenocleft secondary palate

FGFR1 FGFR2 HHAT

5.41e-04127183MP:0009890
MousePhenoabnormal palate development

FGFR1 FGFR2 HHAT

5.66e-04129183MP:0009653
MousePhenoabnormal midface morphology

FGFR1 FGFR2

5.80e-0428182MP:0030095
MousePhenoabnormal rostral-caudal axis patterning

FGFR1 FGFR2 CSK

6.05e-04132183MP:0005221
MousePhenoocular hypertelorism

FGFR1 FGFR2

6.23e-0429182MP:0001300
MousePhenoabnormal neural crest cell morphology

FGFR1 HHAT

6.67e-0430182MP:0009845
MousePhenoabnormal multipotent stem cell morphology

FGFR1 HHAT

7.12e-0431182MP:0002400
MousePhenoabnormal visceral yolk sac blood island morphology

FGFR1 CSK

7.59e-0432182MP:0011204
MousePhenoabnormal neural crest morphology

FGFR1 HHAT

7.59e-0432182MP:0009846
MousePhenoabnormal visceral yolk sac mesenchyme morphology

FGFR1 CSK

9.61e-0436182MP:0020516
MousePhenoabnormal otic vesicle morphology

FGFR2 CSK

9.61e-0436182MP:0009806
MousePhenosmall face

FGFR1 FGFR2

1.02e-0337182MP:0030064
MousePhenoabnormal secondary palate morphology

FGFR1 FGFR2 HHAT

1.04e-03159183MP:0013550
MousePhenoincreased osteoblast cell number

FGFR1 FGFR2

1.07e-0338182MP:0004988
MousePhenooligodactyly

FGFR1 HHAT

1.13e-0339182MP:0000565
MousePhenoabnormal cartilage development

FGFR1 FGFR2 HHAT

1.30e-03172183MP:0000164
MousePhenoabnormal pluripotent precursor cell morphology

FGFR1 HHAT

1.31e-0342182MP:0002399
MousePhenoabnormal face size

FGFR1 FGFR2

1.31e-0342182MP:0030063
MousePhenoabnormal bone ossification

FGFR1 FGFR2 RIC1 HHAT

1.40e-03395184MP:0008271
MousePhenoabnormal hyaline cartilage morphology

FGFR2 HHAT

1.57e-0346182MP:0006429
MousePhenoabnormal palatine bone morphology

FGFR1 FGFR2

1.57e-0346182MP:0005249
MousePhenoabnormal nasal septum morphology

FGFR2 HHAT

1.64e-0347182MP:0002239
MousePhenoabnormal craniofacial development

FGFR1 FGFR2 CSK HHAT

1.84e-03425184MP:0003935
MousePhenoabnormal neural fold morphology

FGFR1 CSK

1.92e-0351182MP:0011256
MousePhenoabnormal palatal shelf elevation

FGFR1 HHAT

1.92e-0351182MP:0009885
MousePhenoabnormal nose morphology

FGFR1 FGFR2 HHAT

2.04e-03201183MP:0002233
MousePhenocaudal body truncation

FGFR1 CSK

2.15e-0354182MP:0004073
MousePhenoabnormal heart atrium size

FGFR1 FGFR2

2.15e-0354182MP:0031576
MousePhenoabnormal basisphenoid bone morphology

FGFR1 FGFR2

2.40e-0357182MP:0000106
MousePhenoabnormal intramembranous bone ossification

FGFR1 FGFR2

2.74e-0361182MP:0008273
MousePhenoabnormal telencephalon morphology

FGFR2 TDO2 ZDHHC17 CSK HHAT

2.97e-03812185MP:0000787
MousePhenoabnormal parietal bone morphology

FGFR2 HHAT

3.01e-0364182MP:0000109
MousePhenoabnormal osteoblast physiology

FGFR1 FGFR2

3.30e-0367182MP:0005006
MousePhenoabnormal heart tube morphology

FGFR1 FGFR2

3.39e-0368182MP:0000270
MousePhenoabnormal nasal bone morphology

FGFR1 FGFR2

3.49e-0369182MP:0000102
MousePhenoabnormal craniofacial suture morphology

FGFR1 FGFR2

3.59e-0370182MP:0030229
DomainFGF_rcpt_fam

FGFR1 FGFR2

7.94e-064222IPR016248
DomainTyrKc

FGFR1 FGFR2 CSK

1.46e-0488223SM00219
DomainTyr_kinase_cat_dom

FGFR1 FGFR2 CSK

1.46e-0488223IPR020635
DomainPROTEIN_KINASE_TYR

FGFR1 FGFR2 CSK

1.95e-0497223PS00109
DomainTyr_kinase_AS

FGFR1 FGFR2 CSK

1.95e-0497223IPR008266
DomainPkinase_Tyr

FGFR1 FGFR2 CSK

4.50e-04129223PF07714
Domain-

KLHL29 KLHL1

4.57e-04272222.130.10.80
DomainSer-Thr/Tyr_kinase_cat_dom

FGFR1 FGFR2 CSK

5.48e-04138223IPR001245
DomainGal_Oxidase_b-propeller

KLHL29 KLHL1

7.26e-0434222IPR015916
DomainKelch

KLHL29 KLHL1

2.10e-0358222SM00612
DomainGal_Oxase/kelch_b-propeller

KLHL29 KLHL1

2.18e-0359222IPR011043
DomainBACK

KLHL29 KLHL1

2.25e-0360222SM00875
DomainBACK

KLHL29 KLHL1

2.32e-0361222PF07707
DomainBACK

KLHL29 KLHL1

2.32e-0361222IPR011705
DomainKelch_1

KLHL29 KLHL1

3.05e-0370222PF01344
DomainKelch_1

KLHL29 KLHL1

3.05e-0370222IPR006652
DomainProtein_kinase_ATP_BS

FGFR1 FGFR2 CSK

9.59e-03379223IPR017441
DomainBTB

KLHL29 KLHL1

1.03e-02131222PF00651
DomainBTB

KLHL29 KLHL1

1.51e-02160222PS50097
DomainPROTEIN_KINASE_ATP

FGFR1 FGFR2 CSK

1.60e-02459223PS00107
DomainBTB

KLHL29 KLHL1

1.88e-02180222SM00225
DomainProt_kinase_dom

FGFR1 FGFR2 CSK

1.90e-02489223IPR000719
DomainPROTEIN_KINASE_DOM

FGFR1 FGFR2 CSK

1.94e-02493223PS50011
DomainBTB/POZ_dom

KLHL29 KLHL1

1.98e-02185222IPR000210
DomainSKP1/BTB/POZ

KLHL29 KLHL1

2.06e-02189222IPR011333
DomainI-set

FGFR1 FGFR2

2.08e-02190222PF07679
DomainIg_I-set

FGFR1 FGFR2

2.08e-02190222IPR013098
PathwayKEGG_MEDICUS_VARIANT_AMPLIFIED_FGFR_TO_PI3K_SIGNALING_PATHWAY

FGFR1 FGFR2

4.90e-059172M47397
PathwayKEGG_MEDICUS_VARIANT_AMPLIFIED_FGFR_TO_RAS_ERK_SIGNALING_PATHWAY

FGFR1 FGFR2

1.42e-0415172M47380
PathwayWP_TRYPTOPHAN_CATABOLISM_LEADING_TO_NAD_PRODUCTION

NMRK1 TDO2

1.63e-0416172M39752
PathwayKEGG_MEDICUS_REFERENCE_REGULATION_OF_GF_RTK_RAS_ERK_SIGNALING_UBIQUITINATION_OF_RTK_BY_CBL

FGFR1 FGFR2

4.04e-0425172M47934
PathwayKEGG_MEDICUS_REFERENCE_FGF_FGFR_PI3K_SIGNALING_PATHWAY

FGFR1 FGFR2

6.24e-0431172M47396
PathwayWP_REGULATION_OF_ACTIN_CYTOSKELETON

FGFR1 FGFR2 CSK

7.20e-04150173M39520
PathwayWP_REGULATION_OF_ACTIN_CYTOSKELETON

FGFR1 FGFR2 CSK

7.48e-04152173MM15834
PathwayKEGG_MEDICUS_REFERENCE_FGF_FGFR_RAS_ERK_SIGNALING_PATHWAY

FGFR1 FGFR2

7.96e-0435172M47379
Pubmed

Conditional knockdown of Fgfr2 in mice using Cre-LoxP induced RNA interference.

FGFR1 FGFR2 HHAT

3.70e-09526315987787
Pubmed

FGF8 is essential for formation of the ductal system in the male reproductive tract.

FGFR1 FGFR2 HHAT

1.68e-071526322110055
Pubmed

FGFR1 down-regulation in differentiating human brain and spinal cord neurospheres.

FGFR1 FGFR2

5.37e-07226215618886
Pubmed

Overexpression of fibroblast growth factor receptors FGFR1 and FGFR2 in renal cell carcinoma.

FGFR1 FGFR2

5.37e-07226221329481
Pubmed

Prognostic value of FGFR gene amplification in patients with different types of cancer: a systematic review and meta-analysis.

FGFR1 FGFR2

5.37e-07226225171497
Pubmed

Accumulation and activation of epidermal γδ T cells in a mouse model of chronic dermatitis is not required for the inflammatory phenotype.

FGFR1 FGFR2

5.37e-07226226081170
Pubmed

Expression of basic fibroblast growth factor, FGFR1 and FGFR2 in normal and malignant human breast, and comparison with other normal tissues.

FGFR1 FGFR2

5.37e-0722621380281
Pubmed

Distinct sets of FGF receptors sculpt excitatory and inhibitory synaptogenesis.

FGFR1 FGFR2

5.37e-07226225926357
Pubmed

Structural and functional diversity in the FGF receptor multigene family.

FGFR1 FGFR2

5.37e-0722628417497
Pubmed

Immunolocalization of fibroblast growth factor receptors 1 and 2 in mouse palate development.

FGFR1 FGFR2

5.37e-07226211391199
Pubmed

Facial suture synostosis of newborn Fgfr1(P250R/+) and Fgfr2(S252W/+) mouse models of Pfeiffer and Apert syndromes.

FGFR1 FGFR2

5.37e-07226221538817
Pubmed

Paracrine interactions through FGFR1 and FGFR2 receptors regulate the development of preimplantation mouse chimaeric embryo.

FGFR1 FGFR2

5.37e-07226236382369
Pubmed

Conditional activation of fibroblast growth factor receptor (FGFR) 1, but not FGFR2, in prostate cancer cells leads to increased osteopontin induction, extracellular signal-regulated kinase activation, and in vivo proliferation.

FGFR1 FGFR2

5.37e-07226214559809
Pubmed

The fibroblast growth factor receptors, FGFR-1 and FGFR-2, mediate two independent signalling pathways in human retinal pigment epithelial cells.

FGFR1 FGFR2

5.37e-07226216188231
Pubmed

Bad bones, absent smell, selfish testes: the pleiotropic consequences of human FGF receptor mutations.

FGFR1 FGFR2

5.37e-07226215863034
Pubmed

Fibroblast Growth Factor Signaling Mediates Pulmonary Endothelial Glycocalyx Reconstitution.

FGFR1 FGFR2

5.37e-07226228187268
Pubmed

Epigenetically controlled fibroblast growth factor receptor 2 signaling imposes on the RAS/BRAF/mitogen-activated protein kinase pathway to modulate thyroid cancer progression.

FGFR1 FGFR2

5.37e-07226217545628
Pubmed

The human fibroblast growth factor receptor genes: a common structural arrangement underlies the mechanisms for generating receptor forms that differ in their third immunoglobulin domain.

FGFR1 FGFR2

5.37e-0722621652059
Pubmed

Conserved use of a non-canonical 5' splice site (/GA) in alternative splicing by fibroblast growth factor receptors 1, 2 and 3.

FGFR1 FGFR2

5.37e-0722629499422
Pubmed

Involvement of fibroblast growth factor receptor genes in benign prostate hyperplasia in a Korean population.

FGFR1 FGFR2

5.37e-07226224385678
Pubmed

Fibroblast growth factor receptors 1 and 2 in keratinocytes control the epidermal barrier and cutaneous homeostasis.

FGFR1 FGFR2

5.37e-07226220308431
Pubmed

FGFR1 and FGFR2 in fibrolamellar carcinoma.

FGFR1 FGFR2

5.37e-07226226259677
Pubmed

Distinct roles of fibroblast growth factor receptor 1 and 2 in regulating cell survival and epithelial-mesenchymal transition.

FGFR1 FGFR2

5.37e-07226217284663
Pubmed

Spatial distribution and functional relevance of FGFR1 and FGFR2 expression for glioblastoma tumor invasion.

FGFR1 FGFR2

5.37e-07226237579831
Pubmed

Inhibition of cellular senescence by developmentally regulated FGF receptors in mesenchymal stem cells.

FGFR1 FGFR2

5.37e-07226221527526
Pubmed

Aberrant FGFR signaling mediates resistance to CDK4/6 inhibitors in ER+ breast cancer.

FGFR1 FGFR2

5.37e-07226230914635
Pubmed

Developmental expression of two murine fibroblast growth factor receptors, flg and bek.

FGFR1 FGFR2

5.37e-0722621667382
Pubmed

FGFR1 and FGFR2 mutations in Pfeiffer syndrome.

FGFR1 FGFR2

5.37e-07226223348274
Pubmed

Loss of Fgfr1 and Fgfr2 in Scleraxis-lineage cells leads to enlarged bone eminences and attachment cell death.

FGFR1 FGFR2

5.37e-07226237212424
Pubmed

Fibroblast growth factor receptor signalling has a role in lobuloalveolar development of the mammary gland.

FGFR1 FGFR2

5.37e-0722629202386
Pubmed

Upper extremity anomalies in Pfeiffer syndrome and mutational correlations.

FGFR1 FGFR2

5.37e-07226224776567
Pubmed

FGF signaling in the osteoprogenitor lineage non-autonomously regulates postnatal chondrocyte proliferation and skeletal growth.

FGFR1 FGFR2

5.37e-07226227052727
Pubmed

FGF receptors 1 and 2 are key regulators of keratinocyte migration in vitro and in wounded skin.

FGFR1 FGFR2

5.37e-07226222992463
Pubmed

FGF receptors 1 and 2 control chemically induced injury and compound detoxification in regenerating livers of mice.

FGFR1 FGFR2

5.37e-07226220603121
Pubmed

Targeted expression of a dominant negative FGF receptor blocks branching morphogenesis and epithelial differentiation of the mouse lung.

FGFR1 FGFR2

5.37e-0722628045260
Pubmed

The neural cell adhesion molecule binds to fibroblast growth factor receptor 2.

FGFR1 FGFR2

5.37e-07226216709412
Pubmed

Two FGF receptor genes are differentially expressed in epithelial and mesenchymal tissues during limb formation and organogenesis in the mouse.

FGFR1 FGFR2

5.37e-0722621315677
Pubmed

Basic fibroblast growth factor (bFGF) and its receptor expression (bek and flg) In bone marrow stroma of murine AIDS.

FGFR1 FGFR2

1.61e-06326215041185
Pubmed

Transient Redirection of SVZ Stem Cells to Oligodendrogenesis by FGFR3 Activation Promotes Remyelination.

FGFR1 FGFR2

1.61e-06326231189094
Pubmed

Different clinical significance of FGFR1-4 expression between diffuse-type and intestinal-type gastric cancer.

FGFR1 FGFR2

1.61e-06326228056982
Pubmed

Immunohistochemical expression of basic fibroblast growth factor and fibroblast growth factor receptors 1 and 2 in the pathogenesis of lung cancer.

FGFR1 FGFR2

1.61e-06326218829480
Pubmed

Aberrations in FGFR1, FGFR2, and RIP5 Expression in Human Congenital Anomalies of the Kidney and Urinary Tract (CAKUT).

FGFR1 FGFR2

1.61e-06326236555181
Pubmed

Activation of fibroblast growth factor (FGF) receptors by recombinant human FGF-5.

FGFR1 FGFR2

1.61e-0632628386828
Pubmed

Identification of residues important both for primary receptor binding and specificity in fibroblast growth factor-7.

FGFR1 FGFR2

1.61e-06326210950949
Pubmed

Acquired FGFR and FGF Alterations Confer Resistance to Estrogen Receptor (ER) Targeted Therapy in ER+ Metastatic Breast Cancer.

FGFR1 FGFR2

1.61e-06326232723837
Pubmed

Characterization of the receptor for keratinocyte growth factor. Evidence for multiple fibroblast growth factor receptors.

FGFR1 FGFR2

1.61e-0632622165484
Pubmed

Humidity-regulated CLCA2 protects the epidermis from hyperosmotic stress.

FGFR1 FGFR2

1.61e-06326229743348
Pubmed

FGFR Craniosynostosis Syndromes Overview

FGFR1 FGFR2

1.61e-06326220301628
Pubmed

Expression and localization of FGFR1, FGFR2 and CTGF during normal human lung development.

FGFR1 FGFR2

1.61e-06326233962151
Pubmed

Osteocyte Death and Bone Overgrowth in Mice Lacking Fibroblast Growth Factor Receptors 1 and 2 in Mature Osteoblasts and Osteocytes.

FGFR1 FGFR2

1.61e-06326231206783
Pubmed

Isolation of the complementary DNA encoding a mouse heparin-binding growth factor receptor with the use of a unique kinase insert sequence.

FGFR1 FGFR2

1.61e-0632628382556
Pubmed

hSef inhibits PC-12 cell differentiation by interfering with Ras-mitogen-activated protein kinase MAPK signaling.

FGFR1 FGFR2

1.61e-06326212958313
Pubmed

Mouse genetics identifies unique and overlapping functions of fibroblast growth factor receptors in keratinocytes.

FGFR1 FGFR2

1.61e-06326231830366
Pubmed

Expression of fibroblast growth factor receptor1, -2c, and -3c transcripts in mouse molars after tooth eruption.

FGFR1 FGFR2

1.61e-06326233433858
Pubmed

Fibroblast growth factor receptor signaling in pediatric B-cell precursor acute lymphoblastic leukemia.

FGFR1 FGFR2

1.61e-06326230755670
Pubmed

Role of fibroblast growth factor receptors (FGFR) and FGFR like-1 (FGFRL1) in mesenchymal stromal cell differentiation to osteoblasts and adipocytes.

FGFR1 FGFR2

1.61e-06326228923346
Pubmed

Expression of fibroblast growth factor receptors (FGFR1, FGFR2, FGFR3) in the developing head and face.

FGFR1 FGFR2

1.61e-0632629286594
Pubmed

Development of covalent inhibitors that can overcome resistance to first-generation FGFR kinase inhibitors.

FGFR1 FGFR2

1.61e-06326225349422
Pubmed

BMP-2 differentially modulates FGF-2 isoform effects in osteoblasts from newborn transgenic mice.

FGFR1 FGFR2

1.61e-06326223715864
Pubmed

FGFR1/3 tyrosine kinase fusions define a unique molecular subtype of non-small cell lung cancer.

FGFR1 FGFR2

1.61e-06326224850843
Pubmed

Conditional mutation of fibroblast growth factor receptors 1 and 2 results in an omphalocele in mice associated with disruptions in ventral body wall muscle formation.

FGFR1 FGFR2

1.61e-06326221238647
Pubmed

Impaired tumor growth and angiogenesis in mice heterozygous for Vegfr2 (Flk1).

FGFR1 FGFR2

1.61e-06326230283071
Pubmed

Fibroblast growth factor (FGF) 3 from Xenopus laevis (XFGF3) binds with high affinity to FGF receptor 2.

FGFR1 FGFR2

1.61e-0632627896824
Pubmed

Phosphorylation of serine 779 in fibroblast growth factor receptor 1 and 2 by protein kinase C(epsilon) regulates Ras/mitogen-activated protein kinase signaling and neuronal differentiation.

FGFR1 FGFR2

1.61e-06326223564461
Pubmed

Pulmonary fibrosis requires cell-autonomous mesenchymal fibroblast growth factor (FGF) signaling.

FGFR1 FGFR2

1.61e-06326228487375
Pubmed

Two FGF Receptor Kinase Molecules Act in Concert to Recruit and Transphosphorylate Phospholipase Cγ.

FGFR1 FGFR2

1.61e-06326226687682
Pubmed

Differential roles of fibroblast growth factor receptors (FGFR) 1, 2 and 3 in the regulation of S115 breast cancer cell growth.

FGFR1 FGFR2

1.61e-06326223185502
Pubmed

FGF-FGFR Mediates the Activity-Dependent Dendritogenesis of Layer IV Neurons during Barrel Formation.

FGFR1 FGFR2

1.61e-06326229097598
Pubmed

Fibroblast growth factor receptors 1 and 2 are differentially regulated in murine embryonal carcinoma cells and in response to fibroblast growth factor-4.

FGFR1 FGFR2

1.61e-0632627593222
Pubmed

Localization patterns of fibroblast growth factor 1 and its receptors FGFR1 and FGFR2 in postnatal mouse retina.

FGFR1 FGFR2

1.61e-06326219408015
Pubmed

Targeting FGFR Pathway in Human Hepatocellular Carcinoma: Expressing pFGFR and pMET for Antitumor Activity.

FGFR1 FGFR2

1.61e-06326226351320
Pubmed

Fibroblast growth factor receptors in in vitro and in vivo chondrogenesis: relating tissue engineering using adult mesenchymal stem cells to embryonic development.

FGFR1 FGFR2

1.61e-06326219728793
Pubmed

Fibroblast growth factor receptor signaling is essential for normal mammary gland development and stem cell function.

FGFR1 FGFR2

1.61e-06326223097355
Pubmed

Fibroblast growth factor signaling regulates neurogenesis at multiple stages in the embryonic olfactory epithelium.

FGFR1 FGFR2

1.61e-06326223137310
Pubmed

Enriched Environment Promotes Adult Hippocampal Neurogenesis through FGFRs.

FGFR1 FGFR2

1.61e-06326233637561
Pubmed

Disruption of fibroblast growth factor receptor signaling in nonmyelinating Schwann cells causes sensory axonal neuropathy and impairment of thermal pain sensitivity.

FGFR1 FGFR2

1.61e-06326219211868
Pubmed

Impaired cerebral cortex development and blood pressure regulation in FGF-2-deficient mice.

FGFR1 FGFR2

1.61e-0632629687490
Pubmed

Fibroblast growth factor receptor (FGFR) gene amplifications are rare events in bladder cancer.

FGFR1 FGFR2

1.61e-06326224898159
Pubmed

Endothelial fibroblast growth factor receptor signaling is required for vascular remodeling following cardiac ischemia-reperfusion injury.

FGFR1 FGFR2

1.61e-06326226747503
Pubmed

Low prognostic implication of fibroblast growth factor family activation in triple-negative breast cancer subsets.

FGFR1 FGFR2

1.61e-06326224385208
Pubmed

FGFR mutations and plagiocephaly.

FGFR1 FGFR2

1.61e-06326218216705
Pubmed

Mast cells are dispensable in a genetic mouse model of chronic dermatitis.

FGFR1 FGFR2

1.61e-06326225843682
Pubmed

Heparan sulfate-related oligosaccharides in ternary complex formation with fibroblast growth factors 1 and 2 and their receptors.

FGFR1 FGFR2

3.22e-06426216807244
Pubmed

Expression patterns of Twist and Fgfr1, -2 and -3 in the developing mouse coronal suture suggest a key role for twist in suture initiation and biogenesis.

FGFR1 FGFR2

3.22e-06426210704861
Pubmed

Somatic FGFR and TWIST mutations are not a common cause of isolated nonsyndromic single suture craniosynostosis.

FGFR1 FGFR2

3.22e-06426217414280
Pubmed

Differential expression of the fibroblast growth factor receptor (FGFR) multigene family in normal human adult tissues.

FGFR1 FGFR2

3.22e-0642629212826
Pubmed

FGF signaling regulates mesenchymal differentiation and skeletal patterning along the limb bud proximodistal axis.

FGFR1 FGFR2

3.22e-06426218094024
Pubmed

Integrin activation is required for VEGF and FGF receptor protein presence on human microvascular endothelial cells.

FGFR1 FGFR2

3.22e-06426211693202
Pubmed

Expression of fibroblast growth factor receptor family members is associated with prognosis in early stage cervical cancer patients.

FGFR1 FGFR2

3.22e-06426227154171
Pubmed

Expression of RUNX2 and its signaling partners TCF7, FGFR1/2 in cleidocranial dysplasia.

FGFR1 FGFR2

3.22e-06426225738174
Pubmed

Responsiveness of developing dental tissues to fibroblast growth factors: expression of splicing alternatives of FGFR1, -2, -3, and of FGFR4; and stimulation of cell proliferation by FGF-2, -4, -8, and -9.

FGFR1 FGFR2

3.22e-0642629664689
Pubmed

FGF22 signaling regulates synapse formation during post-injury remodeling of the spinal cord.

FGFR1 FGFR2

3.22e-06426225766255
Pubmed

EGF-responsive neural stem cells are a transient population in the developing mouse spinal cord.

FGFR1 FGFR2

3.22e-06426211553295
Pubmed

Isolated sagittal and coronal craniosynostosis associated with TWIST box mutations.

FGFR1 FGFR2

3.22e-06426217343269
Pubmed

PCR-based identification of new receptors: molecular cloning of a receptor for fibroblast growth factors.

FGFR1 FGFR2

3.22e-0642621711190
Pubmed

SSH3 promotes malignant progression of HCC by activating FGF1-mediated FGF/FGFR pathway.

FGFR1 FGFR2

3.22e-06426233275222
Pubmed

Astrocyte activation is suppressed in both normal and injured brain by FGF signaling.

FGFR1 FGFR2

3.22e-06426225002516
Pubmed

Fibroblast growth factor signaling in oligodendrocyte-lineage cells facilitates recovery of chronically demyelinated lesions but is redundant in acute lesions.

FGFR1 FGFR2

3.22e-06426225913734
Pubmed

Mesenchymal fibroblast growth factor receptor signaling regulates palatal shelf elevation during secondary palate formation.

FGFR1 FGFR2

3.22e-06426226250517
Pubmed

Molecular mechanism of SSR128129E, an extracellularly acting, small-molecule, allosteric inhibitor of FGF receptor signaling.

FGFR1 FGFR2

3.22e-06426223597563
InteractionNPHP3 interactions

KLHL29 PDE9A CSK

1.87e-0542253int:NPHP3
InteractionMATK interactions

FGFR1 FGFR2 CSK

2.01e-0543253int:MATK
InteractionFGF1 interactions

FGFR1 FGFR2 CSK

2.16e-0544253int:FGF1
InteractionFGF6 interactions

FGFR1 FGFR2

3.09e-057252int:FGF6
InteractionFGF18 interactions

FGFR1 FGFR2

3.09e-057252int:FGF18
InteractionFGF5 interactions

FGFR1 FGFR2

4.12e-058252int:FGF5
InteractionFGF23 interactions

FGFR1 FGFR2

4.12e-058252int:FGF23
InteractionAFF2 interactions

SIAH1 CSK

5.29e-059252int:AFF2
InteractionTMTC1 interactions

ZDHHC17 CSK

6.61e-0510252int:TMTC1
InteractionTBXA2R interactions

FGFR1 ZDHHC17 CSK

6.68e-0564253int:TBXA2R
InteractionKLB interactions

FGFR1 FGFR2

9.68e-0512252int:KLB
InteractionKL interactions

FGFR1 FGFR2

1.33e-0414252int:KL
InteractionIL17RD interactions

FGFR1 CSK

1.54e-0415252int:IL17RD
InteractionFGF10 interactions

FGFR1 FGFR2

1.54e-0415252int:FGF10
InteractionFGF7 interactions

FGFR1 FGFR2

1.75e-0416252int:FGF7
InteractionFGF9 interactions

FGFR1 FGFR2

1.75e-0416252int:FGF9
InteractionSDCBP interactions

SIAH1 TDO2 PDE9A CNOT1 HHAT

1.80e-04440255int:SDCBP
InteractionPALMD interactions

TIMM13 CSK

1.99e-0417252int:PALMD
InteractionCCDC7 interactions

ZDHHC17 CSK

2.23e-0418252int:CCDC7
InteractionNANOS3 interactions

SIAH1 CNOT1

2.49e-0419252int:NANOS3
InteractionFGF8 interactions

FGFR1 FGFR2 CSK

3.16e-04108253int:FGF8
InteractionUSP6NL interactions

FGFR1 FGFR2 CSK

3.33e-04110253int:USP6NL
InteractionRAET1E interactions

FGFR1 FGFR2

3.36e-0422252int:RAET1E
InteractionNECTIN1 interactions

FGFR1 FGFR2

3.36e-0422252int:NECTIN1
InteractionC12orf75 interactions

PDE9A CSK

4.01e-0424252int:C12orf75
GeneFamilyReceptor Tyrosine Kinases|CD molecules

FGFR1 FGFR2

4.92e-0440152321
GeneFamilyKelch like|BTB domain containing

KLHL29 KLHL1

5.43e-0442152617
GeneFamilyBasic leucine zipper proteins|BTB domain containing

KLHL29 KLHL1

5.37e-03134152861
GeneFamilyBlood group antigens|CD molecules|I-set domain containing|Immunoglobulin like domain containing

FGFR1 FGFR2

7.67e-03161152593
GeneFamilyAnkyrin repeat domain containing

ASB4 ZDHHC17

1.67e-02242152403
ToppCellfrontal_cortex-Neuronal-glutamatergic_neuron-L5_PT-L5_PT_ALM_Hpgd|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

FGFR1 TDO2 KLHL1

5.32e-051262639b04ca8a46cc30119baf6ef27711a0b2a6b4a0c9
ToppCellnormal_Pleural_Fluid-B_lymphocytes-Plasma_cells|normal_Pleural_Fluid / Location, Cell class and cell subclass

DPY19L3 CENPL RIC1

6.11e-051322634e37400ae7375e6986f060234c373194603346f8
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

KLHL29 FGFR2 KLHL1

1.41e-04175263284fdc7a9d303636a637041846850d19d114861a
ToppCell3'-Adult-Appendix-Epithelial-mature_enterocytic-Colonocyte|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DPY19L3 DNAAF9 FGFR2

1.43e-0417626323fa02d4c39e0b8faa1658116d50b6233a952ccc
ToppCell3'-Adult-Appendix-Epithelial-mature_enterocytic|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DPY19L3 DNAAF9 FGFR2

1.43e-0417626330adf8f1638c6244586f8101c2590bb964dfae00
ToppCell3'-Pediatric_IBD-SmallIntestine-Mesenchymal-fibroblastic-mLTo|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract

KIAA1755 FGFR1 TDO2

1.53e-04180263d1c52aeceb3627e3c5fb6cc3af77e0400f9380ab
ToppCell5'-Airway_Nasal-Mesenchymal-Fibroblastic|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ZNF469 FGFR1 TDO2

1.53e-04180263935c091bbcd6d10b81dc4731779e5bd98205c99f
ToppCell5'-Airway_Nasal-Mesenchymal|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ZNF469 FGFR1 TDO2

1.53e-041802633dd384b7f3d9582b8fec9fe05100e466e6218b76
ToppCellPND14-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

KIAA1755 ZNF469 FGFR1

1.56e-041812633462aa1c08fbaf613b6278ab2c7a5a0940bf537d
ToppCellPND14-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_mature|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

KIAA1755 ZNF469 FGFR1

1.56e-041812636730e249cac55ae892cc567d9211615882f3dab4
ToppCellfacs-Brain_Non-Myeloid-Cerebellum_-18m-Epithelial|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DPY19L3 TDO2 PDE9A

1.58e-041822635d8b7fe18286e27f0f50c5d2d9be56850e2cb8f4
ToppCellfacs-Brain_Non-Myeloid-Cerebellum_-18m-Epithelial-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DPY19L3 TDO2 PDE9A

1.58e-04182263904804813849b7f7f716ba1554d33b07bc0a701e
ToppCellfacs-Brain_Non-Myeloid-Cerebellum_-18m-Epithelial-Bergmann_glial_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DPY19L3 TDO2 PDE9A

1.61e-0418326399bb4ceb92f6467f2359a42ab2cff6df18825a30
ToppCell5'-Airway_Nasal-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts-Peribronchial_fibroblasts_L.2.1.3.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ZNF469 FGFR1 TDO2

1.61e-041832636d98973098c6d20c5305bce6a83a549a7d8dbfba
ToppCell5'-Airway_Nasal-Mesenchymal-Fibroblastic-fibroblastic_type_2|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ZNF469 FGFR1 TDO2

1.61e-04183263803376f5260de83c48d4f7301278d078a32b3e6e
ToppCell5'-Airway_Nasal-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ZNF469 FGFR1 TDO2

1.61e-04183263cc7f5a17b40e8d901885174922e5fa8877643071
DrugNaMN

NMRK1 FGFR1 FGFR2 TDO2

1.16e-0670264CID000000941
DrugSU4984

FGFR1 FGFR2

1.25e-062262DB02058
DrugPyrantel tartrate [33401-94-4]; Up 200; 11.2uM; MCF7; HT_HG-U133A

ADGRB2 FGFR1 FGFR2 PDE9A HHAT

2.49e-061952652260_UP
DrugNalidixic acid sodium salt hydrate; Up 200; 14.6uM; PC3; HT_HG-U133A

KLHL29 FGFR1 FGFR2 KLHL1 HHAT

2.55e-061962653668_UP
Drugestradiol, USP; Down 200; 0.1uM; PC3; HT_HG-U133A

KLHL29 SIAH1 FGFR1 FGFR2 NUP160

2.68e-061982654432_DN
Drugestrone benzoate

FGFR1 FGFR2

3.76e-063262ctd:C024552
Drug3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-(6-(4-(4-ethylpiperazin-1-yl)-phenylamino)pyrimidin-4-yl)-1-methylurea

FGFR1 FGFR2

7.51e-064262ctd:C568950
DrugPalifermin

FGFR1 FGFR2

1.88e-056262DB00039
DrugAC1L1F8Z

FGFR1 CSK

2.62e-057262CID000003135
Drugponatinib

FGFR1 FGFR2 CSK

6.31e-0568263ctd:C545373
DrugTK-4

FGFR1 CSK

6.85e-0511262CID000132054
Drugvalinomycin; Down 200; 0.1uM; PC3; HT_HG-U133A

KLHL29 FGFR1 FGFR2 TDO2

6.86e-051962645962_DN
DrugBephenium hydroxynaphthoate [3818-50-6]; Up 200; 9uM; PC3; HT_HG-U133A

ADGRB2 FGFR1 FGFR2 HHAT

7.00e-051972644668_UP
Drugnordihydroguaiaretic acid; Down 200; 1uM; PC3; HT_HG-U133A

ADGRB2 SIAH1 FGFR1 FGFR2

7.14e-051982644447_DN
DrugLidocaone hydrochloride [73-78-9]; Up 200; 14.8uM; MCF7; HT_HG-U133A

ADGRB2 KLHL29 FGFR1 FGFR2

7.14e-051982641499_UP
DrugKanamycin A sulfate [25389-94-0]; Down 200; 6.8uM; PC3; HT_HG-U133A

ADGRB2 NMRK1 FGFR2 NUP160

7.42e-052002644625_DN
DrugPD 166285

FGFR1 FGFR2

8.22e-0512262CID005311382
Drug5H-benzo(4,5)cyclohepta(1,2-b)pyridin-5-one

FGFR1 FGFR2

1.49e-0416262ctd:C561052
DiseasePfeiffer syndrome

FGFR1 FGFR2

6.89e-072252cv:C0220658
DiseasePfeiffer type acrocephalosyndactyly

FGFR1 FGFR2

6.89e-072252C2931888
DiseaseJACKSON-WEISS SYNDROME

FGFR1 FGFR2

6.89e-072252123150
DiseaseJACKSON-WEISS SYNDROME

FGFR1 FGFR2

6.89e-072252C0795998
DiseasePfeiffer syndrome (is_implicated_in)

FGFR1 FGFR2

6.89e-072252DOID:14705 (is_implicated_in)
DiseaseFGFR2-related craniosynostosis

FGFR1 FGFR2

6.89e-072252cv:CN231480
DiseasePFEIFFER SYNDROME

FGFR1 FGFR2

6.89e-072252101600
DiseaseJackson-Weiss syndrome

FGFR1 FGFR2

6.89e-072252cv:C0795998
DiseaseCutis Gyrata Syndrome of Beare And Stevenson

FGFR1 FGFR2

6.89e-072252C1852406
DiseaseJackson-Weiss syndrome (is_implicated_in)

FGFR1 FGFR2

6.89e-072252DOID:0111337 (is_implicated_in)
DiseasePfeiffer syndrome (implicated_via_orthology)

FGFR1 FGFR2

6.89e-072252DOID:14705 (implicated_via_orthology)
Diseaseacrocephalosyndactylia (is_implicated_in)

FGFR1 FGFR2

2.07e-063252DOID:12960 (is_implicated_in)
DiseaseCraniofacial dysostosis type 1

FGFR1 FGFR2

2.07e-063252C2931196
DiseasePfeiffer Syndrome

FGFR1 FGFR2

2.07e-063252C0220658
DiseaseTWIST1-related craniosynostosis

FGFR1 FGFR2

4.13e-064252cv:C4551902
Diseasebone disease (implicated_via_orthology)

FGFR1 FGFR2

6.88e-065252DOID:0080001 (implicated_via_orthology)
DiseaseCraniosynostosis syndrome

FGFR1 FGFR2

1.44e-057252cv:C0010278
Diseasecortical thickness

KLHL29 KIAA1755 ZNF469 FGFR1 DNAAF9 CSK HHAT

2.82e-051113257EFO_0004840
DiseaseHead and Neck Carcinoma

FGFR1 FGFR2

3.09e-0510252C3887461
DiseasePR interval

KIAA1755 ZNF469 FGFR1 FGFR2 CNOT1

5.24e-05495255EFO_0004462
DiseaseSkin Abnormalities

ZNF469 FGFR2

5.34e-0513252C0037268
DiseaseSynostotic Posterior Plagiocephaly

FGFR1 FGFR2

8.21e-0516252C1833340
DiseaseSynostotic Anterior Plagiocephaly

FGFR1 FGFR2

8.21e-0516252C2931150
DiseaseMetopic synostosis

FGFR1 FGFR2

8.21e-0516252C1860819
DiseaseCraniosynostosis, Type 1

FGFR1 FGFR2

8.21e-0516252C4551902
DiseaseAcrocephaly

FGFR1 FGFR2

8.21e-0516252C0030044
DiseaseTrigonocephaly

FGFR1 FGFR2

8.21e-0516252C0265535
DiseaseScaphycephaly

FGFR1 FGFR2

8.21e-0516252C0265534
DiseaseBrachycephaly

FGFR1 FGFR2

9.30e-0517252C0221356
DiseaseCraniosynostosis

FGFR1 FGFR2

1.30e-0420252C0010278
Diseaseunipolar depression, mood disorder

KLHL29 DPY19L3 NUP160

1.96e-04134253EFO_0003761, EFO_0004247
DiseaseSquamous cell carcinoma of lung

FGFR1 FGFR2

3.37e-0432252C0149782
DiseaseHuntington's disease (implicated_via_orthology)

ZDHHC17 PDE9A

3.37e-0432252DOID:12858 (implicated_via_orthology)
DiseaseHead and Neck Neoplasms

FGFR1 FGFR2

3.58e-0433252C0018671
DiseaseCleft upper lip

FGFR1 FGFR2

5.01e-0439252C0008924
DiseaseCleft palate, isolated

FGFR1 FGFR2

5.81e-0442252C1837218
DiseaseMalignant Head and Neck Neoplasm

FGFR1 FGFR2

6.38e-0444252C0278996
Diseasehigh grade glioma (implicated_via_orthology)

FGFR1 FGFR2

6.38e-0444252DOID:3070 (implicated_via_orthology)
DiseaseBipolar Disorder

FGFR1 FGFR2 TDO2 PDE9A

6.52e-04477254C0005586
Diseasecortical surface area measurement

KLHL29 KIAA1755 ZNF469 FGFR1 DNAAF9 FGFR2

7.44e-041345256EFO_0010736

Protein segments in the cluster

PeptideGeneStartEntry
HEMCRDEYVMLMTWK

ADGRB2

531

O60241
WNCDHVLMHMMLEAG

ASB4

261

Q9Y574
YEVMKNCWHLDAAMR

CSK

416

P41240
MRMKYLWTSHMCVFA

DPY19L3

481

Q6ZPD9
SDCAENMYIDMMLWR

RIC1

1051

Q4ADV7
ANCTNELYMMMRDCW

FGFR2

726

P21802
ELYMMMRDCWHAVPS

FGFR2

731

P21802
MATVWSERSLHMPMY

OR10H5

46

Q8NGA6
KRMTWFHMDCQDLMA

KIAA1755

966

Q5JYT7
EMAWAMRAMQHAEVY

PBDC1

36

Q9BVG4
HCFCVAQMMYSMVWL

PDE9A

316

O76083
IMCMYEAEMQWKRDY

NDUFB10

76

O96000
WLAELMAHLMYMHAI

HHAT

256

Q5VTY9
MAAMWTACKMDHYVA

CENPL

221

Q8N0S6
TNELYMMMRDCWHAV

FGFR1

726

P11362
HKECGRWMVYRQIMD

DNAAF9

771

Q5TEA3
MMSAISCWMESARHS

NMRK1

66

Q9NWW6
MTKWRYNHVCMVHRM

TDO2

321

P48775
IHLLAMMYSGEMCYW

RIMOC1

206

A6NDU8
VDWVMMQSCFGFHFM

SIAH1

176

Q8IUQ4
WSYKEQMCLMVADML

NUP160

311

Q12769
QLIMHAMAEWYMRGE

CNOT1

536

A5YKK6
IAMCMDRYMDAWNTV

TIMM13

66

Q9Y5L4
HFMWVAVLLMCQMYQ

ZDHHC17

541

Q8IUH5
MCLKEVADVWMYNEH

ZNF469

3151

Q96JG9
AMAEAMQCSELYHMA

KLHL29

441

Q96CT2
FHALMMWVKYDMQSR

KLHL1

376

Q9NR64