Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionnuclear retinoic acid receptor binding

PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14

2.53e-0655354GO:0042974
GeneOntologyMolecularFunctionubiquitin-like ligase-substrate adaptor activity

PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14

1.26e-0582354GO:1990756
GeneOntologyMolecularFunctionenzyme-substrate adaptor activity

PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14

2.25e-0595354GO:0140767
GeneOntologyMolecularFunctionnuclear receptor binding

PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14

3.11e-04187354GO:0016922
GeneOntologyMolecularFunctionephrin receptor activity

EPHA2 NTRK3

5.01e-0419352GO:0005003
GeneOntologyBiologicalProcessblastocyst formation

PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14

9.06e-0678354GO:0001825
GeneOntologyBiologicalProcessoocyte development

PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14

2.33e-0599354GO:0048599
GeneOntologyBiologicalProcessoocyte differentiation

PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14

2.73e-05103354GO:0009994
GeneOntologyBiologicalProcesssomatic stem cell population maintenance

PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14

3.28e-05108354GO:0035019
GeneOntologyBiologicalProcessregulation of ERK1 and ERK2 cascade

PRAMEF1 PRAMEF2 PRAMEF13 EPHA2 PRAMEF14 NTRK3

4.18e-05385356GO:0070372
GeneOntologyBiologicalProcessERK1 and ERK2 cascade

PRAMEF1 PRAMEF2 PRAMEF13 EPHA2 PRAMEF14 NTRK3

6.59e-05418356GO:0070371
GeneOntologyBiologicalProcessoogenesis

PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14

1.37e-04156354GO:0048477
GeneOntologyBiologicalProcessblastocyst development

PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14

2.33e-04179354GO:0001824
GeneOntologyCellularComponentCul2-RING ubiquitin ligase complex

PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14

1.12e-0647354GO:0031462
GeneOntologyCellularComponentubiquitin ligase complex

RMND5B CUL7 PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14

2.35e-05352356GO:0000151
GeneOntologyCellularComponentcullin-RING ubiquitin ligase complex

CUL7 PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14

2.59e-05212355GO:0031461
GeneOntologyCellularComponentacrosomal vesicle

CAPZA3 PRAMEF1 PRAMEF2 PRAMEF13

3.77e-04206354GO:0001669
GeneOntologyCellularComponentinner kinetochore

CENPL CENPI

5.08e-0420352GO:0000939
GeneOntologyCellularComponenttransferase complex

RMND5B IFIT5 CUL7 PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14

9.34e-04963357GO:1990234
GeneOntologyCellularComponentintracellular protein-containing complex

RMND5B CUL7 AGO3 PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14

9.86e-04972357GO:0140535
MousePhenoabnormal spermatogonia proliferation

PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14

2.88e-0647304MP:0002685
MousePhenoabnormal circulating amylase level

USP54 PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14

1.85e-05156305MP:0008804
MousePhenoincreased male germ cell apoptosis

PRAMEF1 PRAMEF2 PRAMEF13 TENT5D PRAMEF14

4.64e-05189305MP:0014052
MousePhenoabnormal jejunum morphology

PRAMEF1 PRAMEF2 PRAMEF13

9.00e-0541303MP:0004002
MousePhenoincreased circulating amylase level

PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14

1.15e-04119304MP:0008806
MousePhenoabnormal male germ cell apoptosis

PRAMEF1 PRAMEF2 PRAMEF13 TENT5D PRAMEF14

1.33e-04236305MP:0008280
MousePhenoabnormal male germ cell physiology

PRAMEF1 PRAMEF2 PRAMEF13 TENT5D PRAMEF14

1.55e-04244305MP:0020362
MousePhenoabnormal tail morphology

DOCK7 PRAMEF1 PRAMEF2 PRAMEF13 EPHA2 PRAMEF14

1.83e-04403306MP:0002111
MousePhenoabnormal germ cell physiology

PRAMEF1 PRAMEF2 PRAMEF13 TENT5D PRAMEF14

2.36e-04267305MP:0020363
MousePhenoincreased kidney weight

PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14

2.47e-04145304MP:0003917
MousePhenoabnormal duodenum morphology

PRAMEF1 PRAMEF2 PRAMEF13

3.40e-0464303MP:0003271
MousePhenolimbs/digits/tail phenotype

DOCK7 PIGN ACSL4 PRAMEF1 PRAMEF2 PRAMEF13 SACS EPHA2 PRAMEF14

9.42e-041258309MP:0005371
MousePhenoabnormal kidney weight

PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14

9.64e-04208304MP:0002707
DomainPRAME_family

PRAMEF1 PRAMEF2 PRAMEF13

4.78e-0619333IPR026271
Domain-

RTN4RL1 LRRC28 PRAMEF1 PRAMEF2 PRAMEF13 NTRK3

1.84e-053213363.80.10.10
DomainL_dom-like

RTN4RL1 LRRC28 PRAMEF1 PRAMEF2 PRAMEF13 NTRK3

2.08e-05328336IPR032675
DomainLRR_8

RTN4RL1 LRRC28 NTRK3

3.36e-03171333PF13855
DomainLRRNT

RTN4RL1 NTRK3

3.94e-0353332PF01462
DomainSAM_1

EPHA2 SCML4

6.41e-0368332PF00536
DomainLRR_1

RTN4RL1 LRRC28 NTRK3

6.70e-03219333PF00560
Domain-

CUL7 EPHA2

7.36e-03733322.60.120.260
DomainTyrKc

EPHA2 NTRK3

1.05e-0288332SM00219
DomainTyr_kinase_cat_dom

EPHA2 NTRK3

1.05e-0288332IPR020635
DomainSAM

EPHA2 SCML4

1.05e-0288332SM00454
DomainCys-rich_flank_reg_C

RTN4RL1 NTRK3

1.10e-0290332IPR000483
DomainLRRCT

RTN4RL1 NTRK3

1.10e-0290332SM00082
DomainLeu-rich_rpt

RTN4RL1 LRRC28 NTRK3

1.20e-02271333IPR001611
DomainGalactose-bd-like

CUL7 EPHA2

1.20e-0294332IPR008979
DomainSAM_DOMAIN

EPHA2 SCML4

1.22e-0295332PS50105
DomainPROTEIN_KINASE_TYR

EPHA2 NTRK3

1.27e-0297332PS00109
DomainSAM

EPHA2 SCML4

1.27e-0297332IPR001660
DomainTyr_kinase_AS

EPHA2 NTRK3

1.27e-0297332IPR008266
DomainLRRNT

RTN4RL1 NTRK3

1.29e-0298332IPR000372
DomainLRRNT

RTN4RL1 NTRK3

1.29e-0298332SM00013
Pubmed

Oocyte-specific gene Oog1 suppresses the expression of spermatogenesis-specific genes in oocytes.

PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14

2.60e-091835429731491
Pubmed

The promoter of the oocyte-specific gene, Oog1, functions in both male and female meiotic germ cells in transgenic mice.

PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14

2.60e-091835423894331
Pubmed

Identification of a new expanding family of genes characterized by atypical LRR domains. Localization of a cluster preferentially expressed in oocyte.

PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14

2.60e-091835414675769
Pubmed

Oogenesin is a novel mouse protein expressed in oocytes and early cleavage-stage embryos.

PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14

2.60e-091835412890732
Pubmed

Pramel7 mediates ground-state pluripotency through proteasomal-epigenetic combined pathways.

PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14

3.29e-091935428604677
Pubmed

Oog1, an oocyte-specific protein, interacts with Ras and Ras-signaling proteins during early embryogenesis.

PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14

4.11e-092035416580637
Pubmed

Pramel7 mediates LIF/STAT3-dependent self-renewal in embryonic stem cells.

PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14

4.11e-092035421425410
Pubmed

Preferentially Expressed Antigen in Melanoma (PRAME) and the PRAME Family of Leucine-Rich Repeat Proteins.

PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14

4.11e-092035426694250
Pubmed

Sertoli cell-only phenotype and scRNA-seq define PRAMEF12 as a factor essential for spermatogenesis in mice.

PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14

6.20e-092235431729367
Pubmed

Oogenesis specific genes (Nobox, Oct4, Bmp15, Gdf9, Oogenesin1 and Oogenesin2) are differentially expressed during natural and gonadotropin-induced mouse follicular development.

PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14

7.50e-092335419480014
Pubmed

MAGE-B4, a binding partner of PRAMEF12, is dispensable for spermatogenesis and male fertility in mice.

PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14

1.07e-082535437451217
Pubmed

Incomplete reactivation of Oct4-related genes in mouse embryos cloned from somatic nuclei.

PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14

1.07e-082535412620990
Pubmed

Expression profiling in transgenic FVB/N embryonic stem cells overexpressing STAT3.

PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14

1.26e-082635418500982
Pubmed

Differences in gene expression between mouse and human for dynamically regulated genes in early embryo.

PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14

1.73e-082835425089626
Pubmed

Thirteen Ovary-Enriched Genes Are Individually Not Essential for Female Fertility in Mice.

PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14

2.31e-083035438786026
Pubmed

LSM14B is essential for oocyte meiotic maturation by regulating maternal mRNA storage and clearance.

PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14

3.03e-083235437889087
Pubmed

Retinoic acid receptors are required for skeletal growth, matrix homeostasis and growth plate function in postnatal mouse.

PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14

4.40e-083535419389355
Pubmed

Mbd3, a component of the NuRD co-repressor complex, is required for development of pluripotent cells.

PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14

1.36e-074635417287250
Pubmed

DUX is a non-essential synchronizer of zygotic genome activation.

PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14

1.91e-075035431806660
Pubmed

Differential expression of PRAMEL1, a cancer/testis antigen, during spermatogenesis in the mouse.

PRAMEF1 PRAMEF2 PRAMEF13

6.29e-071735323565261
Pubmed

Mouse Pramel1 regulates spermatogonial development by inhibiting retinoic acid signaling during spermatogenesis.

PRAMEF1 PRAMEF2 PRAMEF13

6.29e-071735337781892
Pubmed

Pramel15 facilitates zygotic nuclear DNMT1 degradation and DNA demethylation.

PRAMEF1 PRAMEF2 PRAMEF13

7.54e-071835339181896
Pubmed

Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo.

NAV2 PRAMEF1 PRAMEF2 PRAMEF13 CENPL PRAMEF14

8.36e-0732635617015433
Pubmed

USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities.

NAV2 PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14 NTRK3 CENPI

4.17e-0667435737196079
Pubmed

Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways.

VPS13D PRAMEF1 PRAMEF2 PRAMEF13 EPHA2 PRAMEF14

1.93e-0556435621565611
Pubmed

A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain.

AGO3 PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14

2.44e-0534735516033648
Pubmed

ZAR1 and ZAR2 are required for oocyte meiotic maturation by regulating the maternal transcriptome and mRNA translational activation.

PRAMEF1 PRAMEF2 PRAMEF13

2.77e-055835331598710
Pubmed

An abundance of X-linked genes expressed in spermatogonia.

PRAMEF1 PRAMEF2 PRAMEF13

2.92e-055935311279525
Pubmed

Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells.

CENPL CENPI

4.40e-051035216716197
Pubmed

Deterministic and stochastic allele specific gene expression in single mouse blastomeres.

AGO3 PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14

6.32e-0542435521731673
Pubmed

The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres.

CENPL CENPI

1.02e-041535216622420
Pubmed

Structural insights into human CCAN complex assembled onto DNA.

CENPL CENPI

1.33e-041735236085283
Pubmed

Maternal microRNAs are essential for mouse zygotic development.

PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14

1.61e-0427335417369397
Pubmed

Mouse screen reveals multiple new genes underlying mouse and human hearing loss.

ACSL4 AGO3 PRAMEF1 PRAMEF2 PRAMEF13 CENPL PRAMEF14

2.04e-04124235730973865
Pubmed

Transcriptome analysis of mouse stem cells and early embryos.

PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14

4.73e-0436335414691545
Pubmed

The DNA sequence and biological annotation of human chromosome 1.

DOCK7 VPS13D PRAMEF1 PRAMEF2 CENPL PRAMEF14

5.20e-04103135616710414
Pubmed

The human CENP-A centromeric nucleosome-associated complex.

CENPL CENPI

6.07e-043635216622419
Pubmed

Targeting promiscuous heterodimerization overcomes innate resistance to ERBB2 dimerization inhibitors in breast cancer.

EPHA2 NTRK3

7.49e-044035230898150
Cytoband1p36.21

PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14

1.63e-07633541p36.21
CytobandEnsembl 112 genes in cytogenetic band chr1p36

VPS13D PRAMEF1 PRAMEF2 PRAMEF13 EPHA2 PRAMEF14

1.17e-05681356chr1p36
GeneFamilyPRAME family

PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14

9.13e-0924194686
GeneFamilySterile alpha motif domain containing

EPHA2 SCML4

3.80e-0388192760
GeneFamilyTetratricopeptide repeat domain containing|Bardet-Biedl syndrome associated|BBSome

IFIT5 TTC39C

6.39e-03115192769
CoexpressionKOHOUTEK_CCNT2_TARGETS

PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14

4.12e-0681354MM938
CoexpressionMORI_SMALL_PRE_BII_LYMPHOCYTE_UP

PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14

8.80e-0698354MM592
CoexpressionHUANG_GATA2_TARGETS_DN

PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14

8.80e-0698354MM942
CoexpressionKINNEY_DNMT1_METHYLATION_TARGETS

PRAMEF1 PRAMEF2 PRAMEF13

1.27e-0534353MM955
CoexpressionYAUCH_HEDGEHOG_SIGNALING_PARACRINE_DN

NAV2 PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14

5.35e-05309355MM1244
CoexpressionINGRAM_SHH_TARGETS_UP

PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14

5.47e-05156354MM550
CoexpressionFOSTER_KDM1A_TARGETS_UP

PRAMEF1 PRAMEF2 PRAMEF13 TTC39C PRAMEF14

6.04e-05317355MM956
CoexpressionMEISSNER_BRAIN_HCP_WITH_H3_UNMETHYLATED

PRAMEF1 PRAMEF2 PRAMEF13

6.07e-0557353MM1262
CoexpressionBYSTRYKH_HEMATOPOIESIS_STEM_CELL_AND_BRAIN_QTL_TRANS

PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14

9.54e-05180354MM612
CoexpressionZENG_GU_POST_ICB_METAGENE_41

PIGN ACSL4 USP54 CENPL

1.30e-04195354MM17091
CoexpressionGSE7852_TREG_VS_TCONV_DN

RMND5B RTN4RL1 NTRK3 SCML4

1.43e-04200354M5752
CoexpressionYAMAZAKI_TCEB3_TARGETS_DN

PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14

2.52e-04232354MM1019
CoexpressionDESCARTES_ORGANOGENESIS_SCHWANN_CELL_PRECURSOR

PRAMEF1 PRAMEF2 PRAMEF13

3.04e-0498353MM3656
CoexpressionSANSOM_APC_TARGETS

PRAMEF1 PRAMEF2 PRAMEF13 PRAMEF14

3.11e-04245354MM735
ToppCellLPS-IL1RA+antiTNF-Epithelial_alveolar-AT_2|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

NAV2 ACSL4 USP54 EPHA2

1.23e-0518235417ed11a7ea366dd3106400511d5e628d3f1a9c3e
ToppCellLPS-IL1RA+antiTNF-Epithelial_alveolar-AT_2-AT2_Progenitor|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

NAV2 ACSL4 USP54 EPHA2

1.28e-05184354d0c212a8fbaad24597a84018442b25c61c17ea58
ToppCellLPS_anti-TNF-Epithelial_alveolar-AT_2-Differentiating_AT2|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

NAV2 ACSL4 USP54 EPHA2

1.68e-051973541485933986921ff45669d9b7501c8d17050b3e97
ToppCellLPS_IL1RA_TNF-Epithelial_alveolar-AT_2|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

NAV2 ACSL4 USP54 EPHA2

1.71e-05198354aa80315395cb5dffc25927c8a77cd2037aea8772
ToppCellLPS_IL1RA-Epithelial_alveolar-AT_2-Differentiating_AT2|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

NAV2 ACSL4 USP54 EPHA2

1.71e-05198354285f729140b1df029c24f6ca1d2438470ac51794
ToppCellLPS_IL1RA_TNF-Epithelial_alveolar-AT_2-Differentiating_AT2|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

NAV2 ACSL4 USP54 EPHA2

1.78e-05200354e8db082aa4d0597500e4f16a5c0ea3e62c6c59ae
ToppCellLPS_IL1RA_TNF-Epithelial_alveolar|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

NAV2 ACSL4 USP54 EPHA2

1.78e-05200354c89f3cb36bb14c476d6a392bfd3ded1c8feecfeb
Diseasevirologic response measurement, response to abacavir

PIGN PXK

8.39e-0442302EFO_0006905, EFO_0006906
DiseaseGastric Adenocarcinoma

EPHA2 NTRK3

9.63e-0445302C0278701
DiseaseAdenocarcinoma of lung (disorder)

PIGN ACSL4 NTRK3

1.18e-03206303C0152013
Diseasespine bone mineral density

PIGN TMEM135

6.52e-03119302EFO_0007701

Protein segments in the cluster

PeptideGeneStartEntry
LLCALKLYVNDHYPK

CAPZA3

121

Q96KX2
IKKGYDAPLCNLLLF

ACSL4

411

O60488
KYTLQLKYPHLPCLQ

AGO3

316

Q9H9G7
LAAKYGHPQCLKQLL

ANKRD24

121

Q8TF21
FQGLVKLHALYLYKC

RTN4RL1

121

Q86UN2
KLHALYLYKCGLSAL

RTN4RL1

126

Q86UN2
YKILHALGKATPIYL

NTRK3

821

Q16288
GTHYRAYLLKCHKLP

FRMD8P1

251

Q9BZ68
LRDLINCHVYKKYGP

CUL7

556

Q14999
LALYNLLAYVKHLKG

IFIT5

51

Q13325
HYCLTPELLQVKLYP

DOCK7

521

Q96N67
KILCHKYLIGVLAYL

CENPL

321

Q8N0S6
VYYKKCPELLQGLAH

EPHA2

196

P29317
ALCPYVCHLLYLLTK

CENPI

196

Q92674
VYLKHLLPKIENLSY

SACS

3476

Q9NZJ4
KCLSQYPSLGYLKHL

PRAMEF13

311

Q5VWM6
VKFLLPYVHNKLLLY

PTAR1

61

Q7Z6K3
FLLCLVIKKYLIGPY

TMCO3

471

Q6UWJ1
LKGLPSYLYNKVIGC

LRRC28

216

Q86X40
KCLSQYPSLGYLKHL

PRAMEF14

311

Q5SWL7
GLLNCKYHKCPYIIG

NAV2

2241

Q8IVL1
LLKYCSLLVHGFKPA

TENT5D

236

Q8NEK8
KCLSQYPSLGYLKHL

PRAMEF1

311

O95521
KCLSQFPSLGYLKHL

PRAMEF2

311

O60811
YHPLILECKYVKKPL

C10orf82

86

Q8WW14
VYLRLGLEKSPYCHL

RMND5B

241

Q96G75
KLDYYLHKLLPEILQ

TMEM135

56

Q86UB9
CLIKLLPSCLHPYIY

PXK

196

Q7Z7A4
HLIKGRLKENLYPYL

VPS45

476

Q9NRW7
CKELIHLALKGLSYY

PIGN

421

O95427
ICNKYRKILKYPLLH

ZNF677

236

Q86XU0
LKYLLLGAIHKCLGN

TTC39C

486

Q8N584
YLGLKLGPALKLCYH

SCML4

391

Q8N228
LNGLCPKITYLFYKL

XKR9

196

Q5GH70
KCIKGHYQPLLLLYA

USP54

336

Q70EL1
GKHLLPLVVQVLKYC

UNC79

1356

Q9P2D8
HCSLDLYKYKLIRGL

VPS13D

2236

Q5THJ4