Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioncoumarin 7-hydroxylase activity

CYP2A6 CYP2A7 CYP2A13

4.24e-0731513GO:0008389
GeneOntologyMolecularFunctionalpha-glucosidase activity

SI AGL MGAM2

1.45e-0571513GO:0090599
GeneOntologyMolecularFunctionsteroid hydroxylase activity

CYP2A6 CYP2A7 CYP2A13 CYP2R1

1.22e-04341514GO:0008395
GeneOntologyMolecularFunctiondynein intermediate chain binding

DNHD1 DNAH10 DNAH1 DYNLRB1

1.71e-04371514GO:0045505
GeneOntologyMolecularFunctionglucosidase activity

SI AGL MGAM2

1.80e-04151513GO:0015926
GeneOntologyMolecularFunctionminus-end-directed microtubule motor activity

DNHD1 DNAH10 DNAH1

3.18e-04181513GO:0008569
GeneOntologyMolecularFunctionhistone methyltransferase binding

NOP56 LCORL LCOR

3.18e-04181513GO:1990226
GeneOntologyMolecularFunctionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

CYP2A6 CYP2A7 CYP2A13 CYP2R1

5.11e-04491514GO:0016712
GeneOntologyMolecularFunctionalpha-1,4-glucosidase activity

SI MGAM2

5.60e-0451512GO:0004558
GeneOntologyMolecularFunctionarachidonate epoxygenase activity

CYP2A6 CYP2A7 CYP2A13

7.64e-04241513GO:0008392
GeneOntologyMolecularFunctionextracellular matrix protein binding

ITGAV ITGB8

8.35e-0461512GO:1990430
GeneOntologyMolecularFunctionarachidonate monooxygenase activity

CYP2A6 CYP2A7 CYP2A13

1.09e-03271513GO:0008391
GeneOntologyMolecularFunctiondynein light intermediate chain binding

DNHD1 DNAH10 DNAH1

1.21e-03281513GO:0051959
GeneOntologyBiologicalProcesscellular process involved in reproduction in multicellular organism

CFAP47 FOXO3 DNHD1 FNDC3A PRAMEF17 DCST1 DNAH1 ACTL7A KMT2D FBXO5 BRCA2 PDILT GALNTL5 VPS13B

3.18e-0552715014GO:0022412
GeneOntologyBiologicalProcessphenylpropanoid metabolic process

CYP2A6 CYP2A7 CYP2A13

4.36e-05101503GO:0009698
GeneOntologyBiologicalProcesscoumarin metabolic process

CYP2A6 CYP2A7 CYP2A13

4.36e-05101503GO:0009804
GeneOntologyBiologicalProcessgerm cell development

CFAP47 FOXO3 DNHD1 FNDC3A PRAMEF17 DNAH1 ACTL7A KMT2D FBXO5 BRCA2 PDILT GALNTL5 VPS13B

5.27e-0548215013GO:0007281
GeneOntologyCellularComponentinner dynein arm

DNHD1 DNAH10 DNAI3 DNAH1

5.31e-07101514GO:0036156
GeneOntologyCellularComponentaxonemal dynein complex

DNHD1 DNAH10 DNAI3 DNAH1

2.94e-05251514GO:0005858
GeneOntologyCellularComponentdynein complex

DNHD1 DNAH10 DNAI3 DNAH1 DYNLRB1

4.38e-05541515GO:0030286
GeneOntologyCellularComponentintegrin alphav-beta8 complex

ITGAV ITGB8

5.18e-0521512GO:0034686
GeneOntologyCellularComponentcone photoreceptor outer segment

TMEM237 PRKCA CNGA3

5.84e-05111513GO:0120199
GeneOntologyCellularComponentalphav-beta3 integrin-PKCalpha complex

ITGAV PRKCA

1.55e-0431512GO:0035866
GeneOntologyCellularComponentcytoplasmic microtubule

CYP2A6 CYP2A7 CYP2A13 TOGARAM1 FAM161A NIN

4.15e-041331516GO:0005881
GeneOntologyCellularComponentspindle

TOPBP1 PTP4A1 CEP350 PARP4 LATS1 FBXO5 FAM161A HECW2 HSF1 SKA1 NIN

6.42e-0447115111GO:0005819
HumanPhenoIrregularly shaped sperm tail

CFAP47 DNHD1 DNAH10 DNAH1

1.04e-0515504HP:0033393
DomainCyt_P450_E_grp-I_CYP2A-like

CYP2A6 CYP2A7 CYP2A13

1.98e-0641493IPR008067
DomainHTH_psq

LCORL LCOR

6.32e-0521492PF05225
DomainDynein_HC_stalk

DNHD1 DNAH10 DNAH1

1.70e-04141493IPR024743
DomainDynein_heavy_dom-2

DNHD1 DNAH10 DNAH1

1.70e-04141493IPR013602
DomainDHC_N2

DNHD1 DNAH10 DNAH1

1.70e-04141493PF08393
DomainMT

DNHD1 DNAH10 DNAH1

1.70e-04141493PF12777
DomainDHC_fam

DNHD1 DNAH10 DNAH1

2.11e-04151493IPR026983
DomainDynein_heavy

DNHD1 DNAH10 DNAH1

2.11e-04151493PF03028
DomainDynein_heavy_dom

DNHD1 DNAH10 DNAH1

2.11e-04151493IPR004273
DomainGal_mutarotase_N

SI MGAM2

3.75e-0441492IPR031727
DomainNtCtMGAM_N

SI MGAM2

3.75e-0441492PF16863
DomainBRCT

TOPBP1 PARP4 TP53BP1

4.39e-04191493PF00533
DomainCyt_P450_E_grp-I

CYP2A6 CYP2A7 CYP2A13 CYP2R1

4.50e-04451494IPR002401
DomainFYrich_C

KMT2C KMT2D

6.22e-0451492IPR003889
DomainFYrich_N

KMT2C KMT2D

6.22e-0451492IPR003888
DomainFYRC

KMT2C KMT2D

6.22e-0451492SM00542
DomainFYRN

KMT2C KMT2D

6.22e-0451492SM00541
DomainAutophagy-rel_C

ATG2A VPS13B

6.22e-0451492IPR015412
DomainATG_C

ATG2A VPS13B

6.22e-0451492PF09333
DomainFYRN

KMT2C KMT2D

6.22e-0451492PF05964
DomainFYRC

KMT2C KMT2D

6.22e-0451492PF05965
DomainFYRC

KMT2C KMT2D

6.22e-0451492PS51543
DomainFYRN

KMT2C KMT2D

6.22e-0451492PS51542
DomainBRCT

TOPBP1 PARP4 TP53BP1

6.86e-04221493SM00292
Domain-

TOPBP1 PARP4 TP53BP1

7.84e-042314933.40.50.10190
DomainCyt_P450_CS

CYP2A6 CYP2A7 CYP2A13 CYP2R1

8.41e-04531494IPR017972
DomainGlyco_hydro_31_AS

SI MGAM2

9.29e-0461492IPR030458
DomainLipase_euk

LIPJ LIPA

9.29e-0461492IPR025483
DomainAbhydro_lipase

LIPJ LIPA

9.29e-0461492PF04083
DomainAB_hydrolase_lipase

LIPJ LIPA

9.29e-0461492IPR006693
DomainPH_12

PLCH2 PLCL2

9.29e-0461492PF16457
DomainCYTOCHROME_P450

CYP2A6 CYP2A7 CYP2A13 CYP2R1

1.11e-03571494PS00086
DomainBRCT

TOPBP1 PARP4 TP53BP1

1.13e-03261493PS50172
DomainLIPASE_SER

LIPJ LIPA PGAP1

1.13e-03261493PS00120
Domain-

CYP2A6 CYP2A7 CYP2A13 CYP2R1

1.18e-035814941.10.630.10
Domainp450

CYP2A6 CYP2A7 CYP2A13 CYP2R1

1.18e-03581494PF00067
DomainGlyco_hydro_31

SI MGAM2

1.29e-0371492IPR000322
DomainGlyco_hydro_31

SI MGAM2

1.29e-0371492PF01055
DomainGLYCOSYL_HYDROL_F31_1

SI MGAM2

1.29e-0371492PS00129
DomainCyt_P450

CYP2A6 CYP2A7 CYP2A13 CYP2R1

1.34e-03601494IPR001128
DomainBRCT_dom

TOPBP1 PARP4 TP53BP1

1.41e-03281493IPR001357
DomainChorein_N

ATG2A VPS13B

1.72e-0381492PF12624
DomainVPS13_N

ATG2A VPS13B

1.72e-0381492IPR026854
DomainTrefoil

SI MGAM2

1.72e-0381492PF00088
DomainP_TREFOIL_2

SI MGAM2

2.19e-0391492PS51448
DomainPD

SI MGAM2

2.19e-0391492SM00018
DomainNa_channel_asu

SCN7A SCN10A

2.73e-03101492IPR001696
DomainNa_trans_assoc

SCN7A SCN10A

2.73e-03101492IPR010526
DomainNa_trans_assoc

SCN7A SCN10A

2.73e-03101492PF06512
DomainPkinase_C

LATS1 PRKCA ROCK1

3.17e-03371493IPR017892
Domain-

SI MGAM2

3.32e-031114924.10.110.10
DomainP_trefoil_dom

SI MGAM2

3.96e-03121492IPR000519
DomainHTH_Psq

LCORL LCOR

3.96e-03121492IPR007889
DomainHTH_PSQ

LCORL LCOR

3.96e-03121492PS50960
DomainPkinase_C

LATS1 PRKCA ROCK1

4.55e-03421493PF00433
DomainDynein_heavy_chain_D4_dom

DNAH10 DNAH1

5.40e-03141492IPR024317
DomainATPase_dyneun-rel_AAA

DNAH10 DNAH1

5.40e-03141492IPR011704
DomainSEA

MUC16 ADGRF5

5.40e-03141492SM00200
DomainAAA_8

DNAH10 DNAH1

5.40e-03141492PF12780
DomainAAA_5

DNAH10 DNAH1

5.40e-03141492PF07728
DomainEF-hand_like

PLCH2 PLCL2

6.20e-03151492PF09279
Domain-

MUC16 ADGRF5

6.20e-031514923.30.70.960
DomainPI-PLC-Y

PLCH2 PLCL2

6.20e-03151492PF00387
DomainPLCYc

PLCH2 PLCL2

6.20e-03151492SM00149
DomainPLipase_C_Pinositol-sp_Y

PLCH2 PLCL2

6.20e-03151492IPR001711
DomainPIPLC_Y_DOMAIN

PLCH2 PLCL2

6.20e-03151492PS50008
DomainPI-PLC_fam

PLCH2 PLCL2

6.20e-03151492IPR001192
DomainPLC_EF-hand-like

PLCH2 PLCL2

6.20e-03151492IPR015359
DomainPost-SET_dom

KMT2C KMT2D

7.05e-03161492IPR003616
DomainPostSET

KMT2C KMT2D

7.05e-03161492SM00508
DomainPOST_SET

KMT2C KMT2D

7.05e-03161492PS50868
DomainGal_mutarotase_SF_dom

SI MGAM2

7.95e-03171492IPR011013
Pubmed

Regulation of bile acid metabolism in mouse models with hydrophobic bile acid composition.

CYP2A6 CYP2A7 CYP2A13

8.18e-083152331645370
Pubmed

A trans-acting locus regulates transcriptional repression of the female-specific steroid 15 alpha-hydroxylase gene in male mice.

CYP2A6 CYP2A7 CYP2A13

8.18e-08315238297477
Pubmed

Lack of the steroid 15 alpha-hydroxylase gene (Cyp2a-4) in wild mouse strain Mus spretus: rapid evolution of the P450 gene superfamily.

CYP2A6 CYP2A7 CYP2A13

8.18e-08315238188299
Pubmed

Comparison of hamster and mouse reveals interspecies differences in the regulation of hepatic CYP2A isozymes.

CYP2A6 CYP2A7 CYP2A13

8.18e-08315238250953
Pubmed

The structure and characterization of type I P-450(15) alpha gene as major steroid 15 alpha-hydroxylase and its comparison with type II P-450(15) alpha gene.

CYP2A6 CYP2A7 CYP2A13

8.18e-08315232703500
Pubmed

Alteration of the substrate specificity of mouse 2A P450s by the identity of residue-209: steroid-binding site and orientation.

CYP2A6 CYP2A7 CYP2A13

8.18e-083152322217847
Pubmed

Differential distribution of CYP2A6 and CYP2A13 in the human respiratory tract.

CYP2A6 CYP2A7 CYP2A13

8.18e-083152322890016
Pubmed

Reciprocal regulation of sex-dependent expression of testosterone 15 alpha-hydroxylase (P-450(15 alpha)) in liver and kidney of male mice by androgen. Evidence for a single gene.

CYP2A6 CYP2A7 CYP2A13

8.18e-08315233346244
Pubmed

Alteration of mouse cytochrome P450coh substrate specificity by mutation of a single amino-acid residue.

CYP2A6 CYP2A7 CYP2A13

8.18e-08315232733794
Pubmed

Site-directed mutagenesis of mouse steroid 7 alpha-hydroxylase (cytochrome P-450(7) alpha): role of residue-209 in determining steroid-cytochrome P-450 interaction.

CYP2A6 CYP2A7 CYP2A13

8.18e-08315238484736
Pubmed

Cerium-induced strain-dependent increase in Cyp2a-4/5 (cytochrome P4502a-4/5) expression in the liver and kidneys of inbred mice.

CYP2A6 CYP2A7 CYP2A13

8.18e-08315231417950
Pubmed

Impact of nicotine metabolism on nicotine's pharmacological effects and behavioral responses: insights from a Cyp2a(4/5)bgs-null mouse.

CYP2A6 CYP2A7 CYP2A13

8.18e-083152324045421
Pubmed

Highly homologous mouse Cyp2a4 and Cyp2a5 genes are differentially expressed in the liver and both express long non-coding antisense RNAs.

CYP2A6 CYP2A7 CYP2A13

8.18e-083152332987105
Pubmed

Mouse steroid 15 alpha-hydroxylase gene family: identification of type II P-450(15)alpha as coumarin 7-hydroxylase.

CYP2A6 CYP2A7 CYP2A13

8.18e-08315232765478
Pubmed

Sexual dimorphism of testosterone 15 alpha-hydroxylase mRNA levels in mouse liver. cDNA cloning and regulation.

CYP2A6 CYP2A7 CYP2A13

8.18e-08315232415518
Pubmed

Circadian expression of the steroid 15 alpha-hydroxylase (Cyp2a4) and coumarin 7-hydroxylase (Cyp2a5) genes in mouse liver is regulated by the PAR leucine zipper transcription factor DBP.

CYP2A6 CYP2A7 CYP2A13

3.26e-074152310490589
Pubmed

Two steroid 15 alpha-hydroxylase genes and a homologous gene family in mice.

CYP2A6 CYP2A7 CYP2A13

3.26e-07415231970547
Pubmed

Transcriptional regulation by HNF-4 of the steroid 15alpha-hydroxylase P450 (Cyp2a-4) gene in mouse liver.

CYP2A6 CYP2A7 CYP2A13

3.26e-07415239408084
Pubmed

A DNA methylation site in the male-specific P450 (Cyp 2d-9) promoter and binding of the heteromeric transcription factor GABP.

CYP2A6 CYP2A7 CYP2A13

3.26e-07415237565685
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

TET2 ABCA2 TOPBP1 FNDC3A ATG2A VANGL2 KMT2C HECW2 PLCH2 EDEM1 LCOR CNOT1 NIN

6.45e-075291521314621295
Pubmed

A genetic polymorphism in coumarin 7-hydroxylation: sequence of the human CYP2A genes and identification of variant CYP2A6 alleles.

CYP2A6 CYP2A7 CYP2A13

1.62e-06615237668294
Pubmed

Organization and evolution of the cytochrome P450 CYP2A-2B-2F subfamily gene cluster on human chromosome 19.

CYP2A6 CYP2A7 CYP2A13

1.62e-06615238587134
Pubmed

Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses.

CYP2A6 CYP2A7 CYP2A13

2.83e-06715239630227
Pubmed

Organization and evolution of the Cyp2 gene cluster on mouse chromosome 7, and comparison with the syntenic human cluster.

CYP2A6 CYP2A7 CYP2A13

2.83e-067152314630516
Pubmed

Genetic correction of PSA values using sequence variants associated with PSA levels.

TBX3 HNF1B TERT

2.83e-067152321160077
Pubmed

ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

DNHD1 BRCA2 LCOR TP53BP1

5.69e-0627152417525332
Pubmed

DEFOG: a practical scheme for deciphering families of genes.

OR8J3 OR2M2 OR5B2 OR8J1 OR1D4 OR5AL1 OR1D5 OR2AG1

5.86e-06219152812213199
Pubmed

Maternal DHA intake in mice increased DHA metabolites in the pup brain and ameliorated MeHg-induced behavioral disorder.

CYP2A6 CYP2A7 CYP2A13

6.74e-069152337838304
Pubmed

Identification and functional characterization of transcriptional activators in human cells.

TET2 SUPT20H ERF LCORL SRF ZNF217 KMT2C KMT2D ROCK1 LCOR

1.09e-053981521035016035
Pubmed

Association of mitotic regulation pathway polymorphisms with pancreatic cancer risk and outcome.

TOPBP1 PRKCA ROCK1 NIN

1.15e-0532152420056645
Pubmed

Human transcription factor protein interaction networks.

TET2 HNF1B SUPT20H TCF12 ERF NOP56 DNAH10 RPN1 DTNA ZNF217 ZBTB1 DDX27 KMT2C KMT2D GTF3C1 DCP1B SEC24B CNOT1 TP53BP1

1.64e-0514291521935140242
Pubmed

Effect of integrin AV and B8 gene polymorphisms in patients with traumatic brain injury.

ITGAV ITGB8

1.90e-052152231033358
Pubmed

Integrin αvβ8 on T cells suppresses anti-tumor immunity in multiple models and is a promising target for tumor immunotherapy.

ITGAV ITGB8

1.90e-052152234233193
Pubmed

Characterization of a novel CYP2A7/CYP2A6 hybrid allele (CYP2A6*12) that causes reduced CYP2A6 activity.

CYP2A6 CYP2A7

1.90e-052152212325023
Pubmed

Suppressed hepatocyte proliferation via a ROS-HNE-P21 pathway is associated with nicotine- and cotinine-enhanced alcoholic fatty liver in mice.

CYP2A6 CYP2A13

1.90e-052152230876690
Pubmed

CYP2A5 induction and hepatocellular stress: an adaptive response to perturbations of heme homeostasis.

CYP2A6 CYP2A13

1.90e-052152221395539
Pubmed

Expression of αvβ8 integrin on dendritic cells regulates Th17 cell development and experimental autoimmune encephalomyelitis in mice.

ITGAV ITGB8

1.90e-052152221099117
Pubmed

Species differences in coumarin metabolism: a molecular modelling evaluation of CYP2A interactions.

CYP2A6 CYP2A13

1.90e-052152212162851
Pubmed

Molecular characterization of the murine Coh locus: an amino acid difference at position 117 confers high and low coumarin 7-hydroxylase activity in P450coh.

CYP2A6 CYP2A13

1.90e-05215221302041
Pubmed

Structural alteration of mouse P450coh by mutation of glycine-207 to proline: spin equilibrium, enzyme kinetics, and heat sensitivity.

CYP2A6 CYP2A13

1.90e-05215228395817
Pubmed

Absence of cytochrome P450 2A5 enhances alcohol-induced liver injury in mice.

CYP2A6 CYP2A13

1.90e-052152225804444
Pubmed

Effect of pyrazole, cobalt and phenobarbital on mouse liver cytochrome P-450 2a-4/5 (Cyp2a-4/5) expression.

CYP2A6 CYP2A13

1.90e-05215221520280
Pubmed

Induction of apoptosis by L-NMMA, via FKHRL1/ROCK pathway in human gastric cancer cells.

FOXO3 ROCK1

1.90e-052152217044646
Pubmed

Role of CYP2A13 in the bioactivation and lung tumorigenicity of the tobacco-specific lung procarcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone: in vivo studies using a CYP2A13-humanized mouse model.

CYP2A6 CYP2A13

1.90e-052152223917075
Pubmed

CYP2A7 polymorphic alleles confound the genotyping of CYP2A6*4A allele.

CYP2A6 CYP2A7

1.90e-052152216636685
Pubmed

Genomic Landscape of Experimental Bladder Cancer in Rodents and Its Application to Human Bladder Cancer: Gene Amplification and Potential Overexpression of Cyp2a5/CYP2A6 Are Associated with the Invasive Phenotype.

CYP2A6 CYP2A13

1.90e-052152227902773
Pubmed

General structural features that regulate integrin affinity revealed by atypical αVβ8.

ITGAV ITGB8

1.90e-052152231792290
Pubmed

KMT2C/D COMPASS complex-associated diseases [KCDCOM-ADs]: an emerging class of congenital regulopathies.

KMT2C KMT2D

1.90e-052152231924266
Pubmed

Mutation of epigenetic regulators TET2 and MLL3 in patients with HTLV-I-induced acute adult T-cell leukemia.

TET2 KMT2C

1.90e-052152226880370
Pubmed

Outfielders playing in the infield: functions of aging-associated "nuclear" proteins in the mitochondria.

FOXO3 TERT

1.90e-052152225470293
Pubmed

Ten-eleven translocation 2 interacts with forkhead box O3 and regulates adult neurogenesis.

FOXO3 TET2

1.90e-052152228660881
Pubmed

Circadian Regulation of Hepatic Cytochrome P450 2a5 by Peroxisome Proliferator-Activated Receptor γ.

CYP2A6 CYP2A13

1.90e-052152230154104
Pubmed

Expression of CYP2A genes in human liver and extrahepatic tissues.

CYP2A7 CYP2A13

1.90e-052152210353262
Pubmed

Mechanism-based inhibition of cytochrome P450 (CYP)2A6 by chalepensin in recombinant systems, in human liver microsomes and in mice in vivo.

CYP2A6 CYP2A13

1.90e-052152221418183
Pubmed

Identification of the tumor‑suppressive role of circular RNA‑FOXO3 in colorectal cancer via regulation of miR‑543/LATS1 axis.

FOXO3 LATS1

1.90e-052152234549306
Pubmed

Histone H3K4 monomethylation catalyzed by Trr and mammalian COMPASS-like proteins at enhancers is dispensable for development and viability.

KMT2C KMT2D

1.90e-052152228967912
Pubmed

Deletion of leptin signaling in vagal afferent neurons results in hyperphagia and obesity.

LEPR SCN10A

1.90e-052152225161883
Pubmed

Role of CYP2A5 in the clearance of nicotine and cotinine: insights from studies on a Cyp2a5-null mouse model.

CYP2A6 CYP2A13

1.90e-052152219923441
Pubmed

Effects of lipopolysaccharide-stimulated inflammation and pyrazole-mediated hepatocellular injury on mouse hepatic Cyp2a5 expression.

CYP2A6 CYP2A13

1.90e-052152212499123
Pubmed

Function and regulation of the Cyp2a5/CYP2A6 genes in response to toxic insults in the liver.

CYP2A6 CYP2A13

1.90e-052152222497566
Pubmed

DNA methylation and FoxO3a regulate PHLPP1 expression in chondrocytes.

FOXO3 PHLPP1

1.90e-052152229775231
Pubmed

PKC-dependent regulation of Kv7.5 channels by the bronchoconstrictor histamine in human airway smooth muscle cells.

KCNQ5 PRKCA

1.90e-052152228283479
Pubmed

Identification and characterization of Mlr1,2: two mouse homologues of Mblk-1, a transcription factor from the honeybee brain(1).

LCORL LCOR

1.90e-052152212560079
Pubmed

Association of KMT2C/D loss-of-function variants with response to immune checkpoint blockades in colorectal cancer.

KMT2C KMT2D

1.90e-052152236601880
Pubmed

The role of CYP2A5 in liver injury and fibrosis: chemical-specific difference.

CYP2A6 CYP2A13

1.90e-052152226363552
Pubmed

Mouse liver P450Coh: genetic regulation of the pyrazole-inducible enzyme and comparison with other P450 isoenzymes.

CYP2A6 CYP2A13

1.90e-05215222712571
Pubmed

Mll3 and Mll4 Facilitate Enhancer RNA Synthesis and Transcription from Promoters Independently of H3K4 Monomethylation.

KMT2C KMT2D

1.90e-052152228483418
Pubmed

VANGL2 interacts with integrin αv to regulate matrix metalloproteinase activity and cell adhesion to the extracellular matrix.

ITGAV VANGL2

1.90e-052152229097183
Pubmed

Evaluation of inhibition selectivity for human cytochrome P450 2A enzymes.

CYP2A6 CYP2A13

1.90e-052152222696418
Pubmed

The MLL3/4 H3K4 methyltransferase complex in establishing an active enhancer landscape.

KMT2C KMT2D

1.90e-052152234156443
Pubmed

Phosphorylation-mediated interactions with TOPBP1 couple 53BP1 and 9-1-1 to control the G1 DNA damage checkpoint.

TOPBP1 TP53BP1

1.90e-052152231135337
Pubmed

Nicotine enhances alcoholic fatty liver in mice: Role of CYP2A5.

CYP2A6 CYP2A13

1.90e-052152230222954
Pubmed

Up-regulation of CYP2A5 expression by porphyrinogenic agents in mouse liver.

CYP2A6 CYP2A13

1.90e-05215227543189
Pubmed

Inositol hexaphosphate represses telomerase activity and translocates TERT from the nucleus in mouse and human prostate cancer cells via the deactivation of Akt and PKCalpha.

TERT PRKCA

1.90e-052152216979586
Pubmed

A developmentally regulated chaperone complex for the endoplasmic reticulum of male haploid germ cells.

CLGN PDILT

1.90e-052152217507649
Pubmed

Characterization and regulation of sex-specific mouse steroid hydroxylase genes.

CYP2A6 CYP2A13

1.90e-05215222372744
Pubmed

VANGL2 protein stability is regulated by integrin αv and the extracellular matrix.

ITGAV VANGL2

1.90e-052152230472097
Pubmed

The CYP2A3 gene product catalyzes coumarin 7-hydroxylation in human liver microsomes.

CYP2A6 CYP2A7

1.90e-05215222322567
Pubmed

Metabolic effects of CYP2A6 and CYP2A13 on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced gene mutation--a mammalian cell-based mutagenesis approach.

CYP2A6 CYP2A13

1.90e-052152221473878
Pubmed

Reduced Expression of Histone Methyltransferases KMT2C and KMT2D Correlates with Improved Outcome in Pancreatic Ductal Adenocarcinoma.

KMT2C KMT2D

1.90e-052152227280393
Pubmed

Synaptic and glial localization of the integrin alphavbeta8 in mouse and rat brain.

ITGAV ITGB8

1.90e-05215229593935
Pubmed

The CYP2A gene subfamily: species differences, regulation, catalytic activities and role in chemical carcinogenesis.

CYP2A6 CYP2A13

1.90e-05215227581481
Pubmed

Expression and alternative splicing of the cytochrome P-450 CYP2A7.

CYP2A6 CYP2A7

1.90e-05215227864805
Pubmed

Interstrain differences in the expression and activity of Cyp2a5 in the mouse liver.

CYP2A6 CYP2A13

1.90e-052152228298240
Pubmed

Migratory DCs activate TGF-β to precondition naïve CD8+ T cells for tissue-resident memory fate.

ITGAV ITGB8

1.90e-052152231601741
Pubmed

Genetic polymorphisms for a phenobarbital-inducible cytochrome P-450 map to the Coh locus in mice.

CYP2A6 CYP2A13

1.90e-05215226309775
Pubmed

Loss of MLL3/4 decouples enhancer H3K4 monomethylation, H3K27 acetylation, and gene activation during embryonic stem cell differentiation.

KMT2C KMT2D

1.90e-052152236869380
Pubmed

Role of CYP2A5 in the bioactivation of the lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in mice.

CYP2A6 CYP2A13

1.90e-052152222262919
Pubmed

Cloning and expression of a divergent integrin subunit beta 8.

ITGAV ITGB8

1.90e-05215221918072
Pubmed

Modulation of cytochrome P450 2A5 activity by lipopolysaccharide: low-dose effects and non-monotonic dose-response relationship.

CYP2A6 CYP2A13

1.90e-052152225635819
Pubmed

Cryo-EM structure of the αvβ8 integrin reveals a mechanism for stabilizing integrin extension.

ITGAV ITGB8

1.90e-052152230061598
Pubmed

Genetic variation between mice in their metabolism of coumarin and its derivatives.

CYP2A6 CYP2A13

1.90e-0521522566237
Pubmed

Identification and characterization of a 44 kDa protein that binds specifically to the 3'-untranslated region of CYP2a5 mRNA: inducibility, subcellular distribution and possible role in mRNA stabilization.

CYP2A6 CYP2A13

1.90e-05215228611142
Pubmed

Novel causative variants in patients with achromatopsia.

PDE6C CNGA3

1.90e-052152230289319
Pubmed

Crucial roles of mixed-lineage leukemia 3 and 4 as epigenetic switches of the hepatic circadian clock controlling bile acid homeostasis in mice.

KMT2C KMT2D

1.90e-052152225346535
Pubmed

Coumarin toxicity in different strains of mice.

CYP2A6 CYP2A13

1.90e-0521522665441
Pubmed

Integrins AV and B8 Gene Polymorphisms and Risk for Intracerebral Hemorrhage in Greek and Polish Populations.

ITGAV ITGB8

1.90e-052152227476161
Pubmed

Somatic mutations in KMT2D and TET2 associated with worse prognosis in Epstein-Barr virus-associated T or natural killer-cell lymphoproliferative disorders.

TET2 KMT2D

1.90e-052152231311407
Pubmed

The longevity SNP rs2802292 uncovered: HSF1 activates stress-dependent expression of FOXO3 through an intronic enhancer.

FOXO3 HSF1

1.90e-052152229733381
Pubmed

Essential role of the cytochrome P450 enzyme CYP2A5 in olfactory mucosal toxicity of naphthalene.

CYP2A6 CYP2A13

1.90e-052152224104196
InteractionCYP2A7 interactions

CYP2A6 CYP2A7 CYP2A13

3.43e-0731423int:CYP2A7
Cytoband11q12.1

OR8J3 OR5B2 SLC43A1 OR8J1 OR5AL1

2.08e-04161152511q12.1
GeneFamilyCytochrome P450 family 2

CYP2A6 CYP2A7 CYP2A13 CYP2R1

4.37e-053510241001
CoexpressionLAKE_ADULT_KIDNEY_C15_CONNECTING_TUBULE

TRHDE KANSL1L TCF12 FNDC3A ITGAV KMT2C ADAMTS9 PRKCA LCOR BICC1

5.03e-0817114810M39234
CoexpressionCHIBA_RESPONSE_TO_TSA_DN

ITGAV BRCA2 ROCK1 MAPK6

5.42e-06211484M12459
CoexpressionDACOSTA_UV_RESPONSE_VIA_ERCC3_DN

FOXO3 SUPT20H TCF12 TOPBP1 CHD9 TOGARAM1 FNDC3A CEP350 FAM171A1 BRCA2 SEC24B PHLPP1 PRKCA ROCK1 MAPK6 VPS13B TP53BP1

7.25e-0685614817M4500
CoexpressionGSE27241_WT_VS_RORGT_KO_TH17_POLARIZED_CD4_TCELL_TREATED_WITH_DIGOXIN_UP

TET2 DOCK8 FNDC3A CEP350 KMT2C GTF3C1 CELSR2 PRKCA

8.80e-061801488M8239
CoexpressionGSE13762_CTRL_VS_125_VITAMIND_DAY12_DC_UP

HNF1B NOP56 TMEM237 ZSCAN29 BRCA2 SCN7A SERPINA7

2.18e-051481487M1892
CoexpressionRAY_TUMORIGENESIS_BY_ERBB2_CDC25A_UP

ABCA2 UPK1A CPT1B CELSR2 BRCA2 MAPK6 EDEM1 OR2AG1

3.61e-052191488MM1237
CoexpressionAtlasDevelopingGonad_e18.5_epididymis_emap-13166_k-means-cluster#4_top-relative-expression-ranked_1000

LCORL KMT2C SCML2 ADAMTS9 FNIP1 ROCK1 LCOR

3.48e-06971397gudmap_developingGonad_e18.5_epididymis_1000_k4
CoexpressionAtlasDevelopingGonad_e16.5_epididymis_emap-29702_k-means-cluster#3_top-relative-expression-ranked_500

LCORL SCML2 ADAMTS9 FNIP1 LCOR

1.11e-05451395gudmap_developingGonad_e16.5_epididymis_500_k3
CoexpressionAtlasFacebaseRNAseq_e10.5_Neural Epithelium Overlying Lateral Eminence_top-relative-expression-ranked_1000

MPO TBX3 DNAH10 ADAM23 DTNA ITGB8 ZSCAN29 CEP350 LATS1 CELSR2 DCP1B BRCA2 NUP210 PHLPP1 TLE6 ROCK1 RIC3 SEZ6

7.64e-0598313918Facebase_RNAseq_e10.5_Neural Epithelium Overlying Lateral Eminence_1000
CoexpressionAtlasDevelopingGonad_e18.5_epididymis_emap-13166_k-means-cluster#3_top-relative-expression-ranked_500

LCORL SCML2 ADAMTS9 FNIP1 LCOR

7.80e-05671395gudmap_developingGonad_e18.5_epididymis_500_k3
CoexpressionAtlasDevelopingGonad_P2_epididymis_emap-30199_k-means-cluster#3_top-relative-expression-ranked_500

LCORL SCML2 ADAMTS9 LCOR

8.80e-05361394gudmap_developingGonad_P2_epididymis_500_k3
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CFAP47 KANSL1L TBX3 ADAM23 PGAP1 PLCL2 PRKCA MGAM2

2.89e-071901518078f4be52fa4cc8dd9c8d7a2b6d9631c3d902285
ToppCellfacs-Marrow-KLS-18m-Lymphocytic-early_pro_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TBX3 CLGN DSCAM TERT VANGL2 SCN7A ADGRF5

2.39e-0617615177292e014b8f697f0c2e9f47c48333de95cb44a69
ToppCellfacs-Marrow-KLS-18m-Lymphocytic-early_pro-B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TBX3 CLGN DSCAM TERT VANGL2 SCN7A ADGRF5

2.39e-06176151788ca2f83d8301633232735f39b0683efe49d0b86
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TRHDE HNF1B DOCK8 ITGB8 PARP4 ADAMTS9 BICC1

2.98e-0618215175e1b316599436740f1b30875f0ebd33c3edfb2b6
ToppCellCOVID-19-Endothelial_cells-Inflamed_endothelial_cells|COVID-19 / group, cell type (main and fine annotations)

TBX3 RASGRF2 KALRN ADAMTS9 HECW2 ADGRF5 PLXNA2

4.39e-061931517979ebefa527f86bebeea5d94e626ee6c1cc7d53b
ToppCellPND07-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_prolif|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

DSCAM UPK1A ADAM23 CYP2R1 PLD5 SEZ6

1.73e-0515915167ed659163f45e0c4df4782997c0786900c8186c8
ToppCell5'-Adult-SmallIntestine-Epithelial-Tuft-related-Tuft|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TRHDE TET2 ITGB8 KMT2C PRKCA MGAM2

2.36e-0516815168072d0496b7b730c4601009eaa69ec5366d26d73
ToppCellfacs-Diaphragm-Limb_Muscle-24m|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ERF DSCAM DNAH10 UPK1A DNAH1 PLD5

2.44e-05169151612bdc709bc000d7f9061ecd9fbd57233eaacb7e2
ToppCell390C-Endothelial_cells-Endothelial-E-|390C / Donor, Lineage, Cell class and subclass (all cells)

TBX3 LEPR VANGL2 ADAMTS9 HECW2 ADGRF5

3.26e-051781516804ac3725c1f88e2212172bfb9aa01d97a735621
ToppCellfacs-Brain_Non-Myeloid-Striatum-24m-Mesenchymal-ependymal_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRHDE CFAP47 DNAH10 DNAI3 DNAH1 SCN7A

3.26e-051781516b1db59344c074c7c80169fc2c5cd5fc89f3fe463
ToppCell390C-Endothelial_cells-Endothelial-E|390C / Donor, Lineage, Cell class and subclass (all cells)

TBX3 LEPR VANGL2 ADAMTS9 HECW2 ADGRF5

3.26e-051781516ad6dc4a375664c919bd48c35c48a561fc5a7de8c
ToppCellfacs-Brain_Non-Myeloid-Striatum-24m-Mesenchymal-Ependyma|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRHDE CFAP47 DNAH10 DNAI3 DNAH1 SCN7A

3.26e-051781516579cdc14f28b459e200ae2102e0bd4df8a2c0dcb
ToppCellCOVID-19-Endothelial_cells-Endothelial_cells_(other)|COVID-19 / group, cell type (main and fine annotations)

TBX3 RASGRF2 KALRN ADAMTS9 HECW2 ADGRF5

3.58e-05181151626eb4ee57a70dbf54e096b73129fda9dfda1f6ec
ToppCellRA-13._Vascular_Smooth_Muscle|RA / Chamber and Cluster_Paper

KALRN DTNA KCNQ5 ADAMTS9 ROCK1 PLD5

3.81e-051831516818fd886e0188091310825f9145fa53328f2c979
ToppCell368C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

LCORL SLC43A1 AGL SEC24B MAPK6 LCOR

4.05e-0518515167925519b855f76444a0b57382ce35d89457b0b14
ToppCell5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(non-nasal)-Club_(non-nasal)_L.0.4.0.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CYP2A6 CYP2A7 ABCA2 MUC16 FAM171A1 FBXO5

4.30e-051871516f5a202d5f8eb57b57d80815ce98774e04c387383
ToppCellCOVID-19-lung-Vein_EC|lung / Disease (COVID-19 only), tissue and cell type

RASGRF2 KALRN ADAM23 FAM171A1 ADAMTS9 HECW2

4.43e-051881516d582b76fc2faac526c9bf97503041129e1a6a211
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TRHDE HNF1B ITGB8 PARP4 ADAMTS9 BICC1

4.43e-05188151663a4b25a0a6e05f80f1a6dd91b817f3cf49e6b68
ToppCellCOVID-19-Heart-EC_1|COVID-19 / Disease (COVID-19 only), tissue and cell type

RASGRF2 KALRN ADAMTS9 HECW2 ADGRF5 PLXNA2

4.56e-051891516fe49852ba15f948b384d6b4c258927c70b741357
ToppCellCOVID-19-Endothelial_cells-Endothelial_cells_(general)|COVID-19 / group, cell type (main and fine annotations)

TBX3 RASGRF2 ADAMTS9 HECW2 ADGRF5 PLXNA2

4.70e-051901516812e11314c76c0179fbe5a9bea29b41ce5cbc93d
ToppCellCOVID-19-Endothelial_cells|COVID-19 / group, cell type (main and fine annotations)

RASGRF2 KALRN ADAMTS9 HECW2 ADGRF5 PLXNA2

4.70e-0519015169fbd92cd6d4683b2490504d29c43cf42020433d4
ToppCellEndothelial-A-Myositis-ILD_01|World / lung cells shred on cell class, cell subclass, sample id

TBX3 RASGRF2 ADAM23 LEPR FAM171A1 ADAMTS9

4.84e-051911516f702dfe88a9b04091dae87df61b2b4f43525f86a
ToppCellPBMC-Severe-Myeloid-Neutrophil-immature_Neutrophil-Neu_4|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

MPO DNAH10 FBXO5 FAR2 BRCA2 SKA1

5.12e-051931516ccab6a0c76f574ef7e1d6d5f1e620376daf21bbf
ToppCellfacs-Thymus-nan-3m-Lymphocytic-DN_to_DP_transition_(most_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MPO KANSL1L TCF12 KMT2C LIPA EDEM1

5.12e-051931516a6a864644e1b80b7417ea0a27281e79068a3fd3d
ToppCellRV-09._Endothelium_I|World / Chamber and Cluster_Paper

TBX3 RASGRF2 KALRN ADAMTS9 ADGRF5 PLXNA2

5.12e-051931516e3fa47e2c7cd8a5b69186711c57751f2296de8ae
ToppCellRV-09._Endothelium_I|RV / Chamber and Cluster_Paper

TBX3 RASGRF2 KALRN ADAMTS9 ADGRF5 PLXNA2

5.27e-0519415167b408096e717f2327c12aea35a8d5fc4621d3b06
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

TRHDE KANSL1L HNF1B ITGB8 PARP4 BICC1

5.27e-051941516e577d9e88390b36b5a09b97fe1026089892275a3
ToppCellIPF-Endothelial|IPF / Disease state, Lineage and Cell class

RASGRF2 KALRN FAM171A1 ADAMTS9 HECW2 ADGRF5

5.27e-0519415169591993aa2dcba3d09a0f1ea8b8f2439c26482d6
ToppCellPBMC-Severe-Myeloid-Neutrophil-immature_Neutrophil-Neu_4|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

MPO DNAH10 FBXO5 FAR2 BRCA2 SKA1

5.27e-05194151623318a1b55895b5166c6151f488a94a09b4627ff
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

RASGRF2 KALRN LEPR ADGRF5 PLD5 PLXNA2

5.43e-0519515166bdef651cf73d7381e5012d0eb3c809138fb6b92
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

TRHDE KANSL1L HNF1B ITGB8 FAM171A1 BICC1

5.43e-0519515166477e6e7be5bd8eb99119a12ae16334ccddecd43
ToppCellCOVID-19-Heart-EC_1|Heart / Disease (COVID-19 only), tissue and cell type

RASGRF2 KALRN ADAMTS9 HECW2 ADGRF5 PLXNA2

5.43e-05195151650a193475db1bb1e05b8590225a553688c372c14
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

RASGRF2 KALRN ADAMTS9 HECW2 ADGRF5 PLXNA2

5.58e-0519615167cbb19108b4553ef60ef5c230a29de1662c02efe
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-IPC/newborn-38|World / Primary Cells by Cluster

CHD9 CELSR2 PGAP1 ROCK1 PLXNA2 SEZ6

5.58e-05196151638da0751941adca650fe9b383d9f343153978eb5
ToppCellASK454-Endothelial-Endothelium|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq

TBX3 LEPR VANGL2 ADAMTS9 HECW2 ADGRF5

5.58e-0519615162b777a2026b56839112fd179f2db482c49f4594a
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Endothelial|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

RASGRF2 KALRN ADAMTS9 HECW2 ADGRF5 PLXNA2

5.58e-0519615164cd1e6b7a791e11a40b19f971b7011bd11fe6273
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-IPC/newborn|World / Primary Cells by Cluster

CHD9 CELSR2 PGAP1 ROCK1 PLXNA2 SEZ6

5.58e-051961516721650a08d260faf530dbd52d4e9275d27f3bac2
ToppCellBronchial-NucSeq-Epithelial-Epi_submucosal-gland-Myoepithelial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

DTNA ITGB8 KCNQ5 PLCH2 PLD5 BICC1

5.58e-051961516a58bdf9de05d13d84211e09a933679d485bf8ab4
ToppCell3'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophage_proliferating-Alveolar_macrophage_proliferating_L.1.0.7.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ADAM23 LEPR FBXO5 BRCA2 ADAMTS9 SKA1

5.58e-051961516eb8c9a4a5eb21d43ff7b25deae5896c236f669b9
ToppCellCOVID-19-lung-Capillary_1|lung / Disease (COVID-19 only), tissue and cell type

TCAF2 TBX3 LEPR FAM171A1 HECW2 ADGRF5

5.74e-0519715167e86ff9dafcbaaa7464d61484dd48bfeb7eae6e4
ToppCellParenchymal-NucSeq-Stromal-Fibroblastic-Fibro_peribronchial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

TRHDE GLT8D2 TBX3 LEPR SCN7A BICC1

5.74e-05197151644673c38384453207871d3fd8e8ba9093cc06bc5
ToppCellIPF-Stromal-Myofibroblast|Stromal / Disease state, Lineage and Cell class

RASGRF2 DTNA ITGB8 SCN7A VPS13B BICC1

5.74e-051971516f304d42fc4936fe20996e07c8dccc698a6e5e5ef
ToppCellParenchymal-NucSeq-Endothelial-Endothelia_vascular-VE_systemic_venous|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

RASGRF2 KALRN ADAM23 LEPR FAM171A1 ADAMTS9

6.07e-051991516e2d5c5cab102e67b0131b02392d81adaedc15965
ToppCellCOVID-19_Severe-immature_Neutrophil|COVID-19_Severe / Disease condition and Cell class

MPO FBXO5 FAR2 BRCA2 AGL SKA1

6.07e-051991516f82fa9d651e78f9ebbe6264e00a48c54b1786a69
ToppCellCOVID-19_Severe-immature_Neutrophil-|COVID-19_Severe / Disease condition and Cell class

MPO FBXO5 FAR2 BRCA2 AGL SKA1

6.07e-05199151642ea0c19c455bdb0ae89b428d09c333104c670dc
ToppCellParenchyma_COVID-19-Endothelial-TX|Parenchyma_COVID-19 / Sample group, Lineage and Cell type

ADAM23 LEPR FAM171A1 ADAMTS9 HECW2 ADGRF5

6.24e-052001516abcbd5a156aa4fd51d284441388975c81c0b88ae
ToppCellLung_Parenchyma-Severe-Endothelial|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

ADAM23 LEPR FAM171A1 ADAMTS9 HECW2 ADGRF5

6.24e-052001516d9d0ffa18e5b4647966e19ad9830cbba6120677e
ToppCellBronchial-NucSeq-Immune_Lymphocytic-T-T_CD4-CD4_naive/CM|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

RASGRF2 DOCK8 ADAM23 JAK3 NUP210 PLCL2

6.24e-052001516e0cec0a844b7c1f8edee4c005af27766754e470a
ToppCellLung_Parenchyma-Severe-Endothelial-Endothelial|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

ADAM23 LEPR FAM171A1 ADAMTS9 HECW2 ADGRF5

6.24e-052001516e9d5ba140cabae11c437012d519b85f5412dcc94
ToppCellBronchial-NucSeq-Stromal-Fibroblastic-Fibro_peribronchial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

GLT8D2 TBX3 ITGB8 LEPR SCN7A BICC1

6.24e-052001516fb53be20392a8309a7393774c774a1b1aec6e676
ToppCellLPS-IL1RA+antiTNF-Epithelial_alveolar-AT_1-Airway|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

HNF1B DNAH10 ASTL JAK3 RIC3

6.51e-051241515a7b7d8b14d1218194da8fcf69b4780b6e9469332
ToppCellTCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Acinar_Adenocarcinoma-7|TCGA-Lung / Sample_Type by Project: Shred V9

SI CLRN3 SCN7A PRKCA ADGRF5

8.14e-0513015150219d0d5d21df08f816569c7eb34f1bfa095d29a
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_ILC-NK_cell-NK_c02-NCAM1|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

OR8J3 ASTL DNAH1 PLCH2 ADGRF5

9.73e-051351515b444005987093efab3265201b3541d7941816cc2
ToppCellsaliva-Mild-Moderate_progression_d12-25-Myeloid-Granulocytic-Neutrophil-Neu_c2-CXCR4(low)|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

KALRN DOCK8 DNAH1 JAK3 PLCL2

1.64e-041511515b698ddc74565d47892c09c3f16d78038da2dd5e7
ToppCellCOVID-19-Epithelial_cells-Airway_mucous|COVID-19 / group, cell type (main and fine annotations)

CFAP47 CYP2A13 DNAH10 MUC16 CAPN13

1.64e-0415115158216462e723fec2797387929dde095370947e10a
ToppCellChildren_(3_yrs)-Mesenchymal-myofibroblast_cell-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

TBX3 PDK4 DCST1 SCN7A SKA1

1.70e-041521515621e9b33cd3bb1c7b7d0633069f286b203e3d9c0
ToppCellfacs-Marrow-KLS-18m-Lymphocytic|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TBX3 DSCAM TERT SCN7A BICC1

1.80e-04154151537765512dfae557b9f6eb30a29463b93682a4404
ToppCellChildren_(3_yrs)-Epithelial-basal_cell-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

CYP2A6 CYP2A7 VANGL2 CAPN13 PLXNA2

1.97e-0415715156ee2692f705bdd93ba523dffaf2f0cd921b47e28
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRHDE DNAH10 DTNA PTPRQ PLD5

2.15e-041601515c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRHDE DNAH10 DTNA PTPRQ PLD5

2.15e-04160151525c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCell390C-Endothelial_cells-Endothelial-E|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

DNHD1 TBX3 LEPR VANGL2 ADGRF5

2.28e-04162151545be019b50e3727fc9d3fad2ff78e74e4f2d746b
ToppCell390C-Endothelial_cells-Endothelial-E-|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

DNHD1 TBX3 LEPR VANGL2 ADGRF5

2.28e-041621515fbb0cc2b1434a340dc35058b77c73ea61004c252
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Degenerative_Descending_Thin_Limb_Cell_Type_3|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TRHDE HNF1B PARP4 ADAMTS9 BICC1

2.41e-0416415151cb5fbd7050650047ad6f2ca792118e98d58d22b
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TRHDE HNF1B ITGB8 ADAMTS9 BICC1

2.41e-041641515382e42701779d12a7948690b3be72d06dd75c8b4
ToppCellEndothelial-endothelial_cell_of_bronchial_vessel|World / Lineage, Cell type, age group and donor

RASGRF2 KALRN LEPR ADAMTS9 HECW2

2.48e-04165151584e553d699ac56df89a77248f7308b9133e1b683
ToppCell356C-Fibroblasts-Fibroblast-D|356C / Donor, Lineage, Cell class and subclass (all cells)

GLT8D2 ADAM23 LEPR SCN7A FBXO39

2.55e-0416615157286a37b2827f3747469ffd0d76cbe81116db7ee
ToppCell356C-Fibroblasts-Fibroblast-D-|356C / Donor, Lineage, Cell class and subclass (all cells)

GLT8D2 ADAM23 LEPR SCN7A FBXO39

2.55e-0416615157c2eee0a4f45795a956acf936b85bdb35f1b1624
ToppCell5'-GW_trimst-1.5-LargeIntestine-Epithelial-epithelial_progenitor_cell-Distal_progenitor|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

HNF1B UPK1A MUC16 ZNF217 ASTL

2.62e-041671515720dc5855c856b478b5ca90156b30bfcc5518d60
ToppCellfrontal_cortex-Non-neuronal-leptomeningeal_cell-VLMC-VLMC_Osr1_Mc5r|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

TBX3 APOF LEPR ADAMTS9 BICC1

2.70e-0416815159930bd63b60c03f0152838a79eef77da1c2dd8e5
ToppCelldroplet-Marrow-nan-24m-Lymphocytic-NK_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GLT8D2 KALRN ACAD10 LIPA C1orf105

2.70e-041681515e979a4fbeb9f21048b47d69e6da75c57650697f2
ToppCellFrontal_cortex-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1-Endothelial_Tip.Dcn.Col15a1_(Col15a1)-|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

DNAH10 SLC43A1 APOF PDILT

2.71e-04921514d2c1d25e5bb6ba4f406e916e3c0a5ad05492e59d
ToppCellFrontal_cortex-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1-Endothelial_Tip.Dcn.Col15a1_(Col15a1)|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

DNAH10 SLC43A1 APOF PDILT

2.71e-04921514926e02725a03d8473eda25d4aef63e34a6566224
ToppCellIonocyte-iono-1|World / Class top

DTNA AGL PDILT PLCL2 ADGRF5

2.77e-0416915154b68bcb4b5fc3cd2db23cd4edace7444aa2d605c
ToppCellTCGA-Stomach-Primary_Tumor-Stomach_Adenocarcinoma-Stomach_Adenocarcinoma_-_Tubular-3|TCGA-Stomach / Sample_Type by Project: Shred V9

DNHD1 RASGRF2 HECW2 ADGRF5

2.82e-04931514d108fce6bc55e76ba1861ab601bffca29b85b8fa
ToppCellAdult-Endothelial-endothelial_cell_of_bronchial_vessel-D122|Adult / Lineage, Cell type, age group and donor

KALRN ADAM23 FAM171A1 ADAMTS9 HECW2

2.85e-041701515a99cb3d21f8eb926886340ea99491e078e607648
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_B-B_cell-B_c04-SOX5-TNFRSF1B|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)

KALRN PARP4 PLCL2 PLD5 SKA1

2.85e-04170151509bcbc7eb3b1d35cf03f01ce2f2fe37373382dd4
ToppCellAdult-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D122|Adult / Lineage, Cell type, age group and donor

TBX3 UPK1A KALRN HECW2 PLXNA2

2.93e-041711515bd20e85d36fa9d7ddc8afef6a1dea75efc9ee1dc
ToppCellmetastatic_Brain-B_lymphocytes-Undetermined|B_lymphocytes / Location, Cell class and cell subclass

TCAF2 VPS37A ERF TOPBP1 KCNQ5

2.93e-0417115150d14bc9688c427ba2265984987dc3eea195b19eb
ToppCellPosterior_cortex-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2-Th.Nr4a2_(Neuron.Gad1Gad2-Th.Nr4a2)--|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

DNHD1 HNF1B PDK4 C1orf105

2.94e-04941514c73e99890431750b74f984de5c82e33533ab708b
ToppCellPosterior_cortex-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2-Th.Nr4a2_(Neuron.Gad1Gad2-Th.Nr4a2)-|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

DNHD1 HNF1B PDK4 C1orf105

2.94e-049415141bda61101f45f5c4a68453087b880fdc6d9acfca
ToppCellPosterior_cortex-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2-Th.Nr4a2_(Neuron.Gad1Gad2-Th.Nr4a2)|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

DNHD1 HNF1B PDK4 C1orf105

2.94e-049415149664f74bc0168c92fb8a68cad628323c476f6103
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TRHDE ITGB8 PTP4A1 ADAMTS9 BICC1

3.01e-0417215150c2d0bb767e5ce089b42ad49e8b303a103de2d5c
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TRHDE ITGB8 PTP4A1 ADAMTS9 BICC1

3.01e-041721515eeed177a03c116e9815a8e086d24efc9643b16a4
ToppCellControl-Endothelial_cells-Systemic_venous_endothelial_cells|Control / group, cell type (main and fine annotations)

RASGRF2 KALRN ADAM23 FAM171A1 ADAMTS9

3.01e-041721515c55dce1ed3ed7312394b4e050e1de852a994e130
ToppCellTCGA-Head_and_Esophagus-Solid_Tissue_Normal-Head_and_Neck-Head_and_Neck_normal_tissue-5|TCGA-Head_and_Esophagus / Sample_Type by Project: Shred V9

MPO CYP2A13 DNAH10 MUC16 DNAI3

3.01e-0417215156b8a8d3b97c10b9d092307eed3cacbd2745df185
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell_prolif|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TCAF2 FAM171A1 FAR2 HECW2 ADGRF5

3.01e-041721515c056d44e2e130ceccadfcdceb192a7f095d779c8
ToppCellFrontal_cortex-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Sst-Inhibitory_Neuron.Gad1Gad2.Sst-Pdyn_(MGE-derived_cortical_interneurons--Martinotti_cells)-|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

CLRN3 C1orf105 FBXO39

3.10e-0439151366fe368f1dfe665c661cf9baf854d12eb28c25b8
ToppCellFrontal_cortex-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Sst-Inhibitory_Neuron.Gad1Gad2.Sst-Pdyn_(MGE-derived_cortical_interneurons--Martinotti_cells)|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

CLRN3 C1orf105 FBXO39

3.10e-04391513d5b0bcdfb27c881049178079c48deb587a0b2fda
ToppCellClub-club-15|World / Class top

HNF1B ERF FAR2 CYP2R1 SKA1

3.25e-041751515ca9d012f520f697c7450ec6958a015e20538a6a8
ToppCell3'-GW_trimst-1.5-SmallIntestine-Neuronal-neuron_precursor|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CLGN TCF12 DSCAM KCNQ5 RIC3

3.25e-0417515152ce8bcf9926862e723219b4246388428d0c3fdee
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TRHDE HNF1B PARP4 ADAMTS9 BICC1

3.34e-041761515327a3e81b724252e36d786de92a3ffd721ea6d7b
ToppCell3'-GW_trimst-1.5-SmallIntestine-Neuronal-neuron_precursor-Neuroblast|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CLGN TCF12 DSCAM KCNQ5 RIC3

3.43e-041771515d1dd778d1a52305b1ea3954f81fd5364b3d57bbe
ToppCell5'-GW_trimst-2-SmallIntestine-Endothelial-blood_vessel_EC-arterial_capillary|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RASGRF2 ADAMTS9 HECW2 ADGRF5 PLXNA2

3.70e-041801515755050226eeb1991ee7f0d15e39d0458f3e4a791
ToppCelldroplet-Lung-30m-Hematologic-lymphocytic-Zbtb32+_B_cell|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SUPT20H UPK1A SLC43A1 KCNQ5 PRKCA

3.70e-041801515c12c1cc206f7e63e5722471bd3eb84caddb84129
ToppCelldroplet-Lung-30m-Hematologic-lymphocytic-Zbtb32+_B_cell-Zbtb32+_B_cell|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SUPT20H UPK1A SLC43A1 KCNQ5 PRKCA

3.70e-041801515d8135f73a89b97168f2048258f4648e23536ece4
ToppCelldroplet-Liver-hepatocytes-3m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RASGRF2 ADAM23 FAM171A1 HECW2 ADGRF5

3.80e-0418115154df7972f88117108698efd06b124b232f8588981
ToppCellCOVID-19-Endothelial_cells-Capillary_endothelial_cells|COVID-19 / group, cell type (main and fine annotations)

TBX3 KALRN HECW2 ADGRF5 PLXNA2

3.80e-041811515c5f9c92af1384d9089c65afdf41c6feb8345a3ae
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TRHDE HNF1B DOCK8 ITGB8 BICC1

3.80e-0418115156956ecd6264f7469a25e555673bce4eb97d28f7a
ToppCelldroplet-Liver-hepatocytes-3m-Endothelial|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RASGRF2 ADAM23 FAM171A1 HECW2 ADGRF5

3.80e-041811515cbb530566893281289026bfd93adf721decd4ca3
ToppCelldroplet-Marrow-nan-3m-Myeloid-nan|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DOCK8 CHD9 CEP350 PGAP1 NIN

3.89e-041821515f8c73baaaca145e2efc48f10f636feb79c8fc779
Drug2'-methoxyacetophenone

CYP2A6 CYP2A7 CYP2A13

2.64e-0731473CID000068481
Diseaseesophagus squamous cell carcinoma (is_implicated_in)

TET2 TERT KMT2C KMT2D BRCA2

2.88e-06451465DOID:3748 (is_implicated_in)
Diseaseneutrophil count, eosinophil count

MPO TET2 RPN1 DOCK8 TERT LEPR THADA LIPA

1.16e-052131468EFO_0004833, EFO_0004842
DiseaseStreptozotocin Diabetes

MPO FOXO3 PDK4 CPT1B LEPR PRKCA

1.67e-051081466C0038433
DiseaseDiabetes Mellitus, Experimental

MPO FOXO3 PDK4 CPT1B LEPR PRKCA

1.67e-051081466C0011853
DiseaseAlloxan Diabetes

MPO FOXO3 PDK4 CPT1B LEPR PRKCA

1.67e-051081466C0002152
DiseaseKleefstra syndrome 2 (implicated_via_orthology)

KMT2C KMT2D

2.43e-0521462DOID:0080598 (implicated_via_orthology)
Diseaseneutrophil percentage of leukocytes

MPO TET2 KALRN RPN1 DOCK8 TERT ZBTB1 LEPR THADA LIPA GTF3C1 PTCD1

5.45e-0561014612EFO_0007990
Diseaseadhesion G protein-coupled receptor F5 measurement

RHCE ADGRF5

7.27e-0531462EFO_0801346
Diseasehepatocellular clear cell carcinoma (is_marker_for)

TERT LEPR

7.27e-0531462DOID:5016 (is_marker_for)
Diseaseserum alanine aminotransferase measurement

FOXO3 CYP2A6 HNF1B LCORL SLC43A1 LEPR CDH20 CELSR2 ADAMTS9 NUP210 PRKCA DYNLRB1 CNOT1 NIN

1.10e-0486914614EFO_0004735
Diseaselung carcinoma, estrogen-receptor negative breast cancer, ovarian endometrioid carcinoma, colorectal cancer, prostate carcinoma, ovarian serous carcinoma, breast carcinoma, ovarian carcinoma, lung adenocarcinoma, squamous cell lung carcinoma

TET2 HNF1B TERT BRCA2

1.29e-04521464EFO_0000305, EFO_0000571, EFO_0000708, EFO_0001071, EFO_0001075, EFO_0001663, EFO_1000650, EFO_1001515, EFO_1001516, MONDO_0005575
Diseaseneutrophil count, basophil count

MPO TET2 RPN1 DOCK8 TERT LEPR THADA

1.31e-042241467EFO_0004833, EFO_0005090
DiseaseAchromatopsia

PDE6C CNGA3

2.41e-0451462cv:C0152200
Diseasegranulocyte count

MPO TET2 RPN1 DOCK8 TERT LEPR THADA

2.83e-042541467EFO_0007987
Diseasemyeloperoxidase measurement

MPO RPN1 THADA

2.84e-04261463EFO_0005243
DiseaseSezary Syndrome

TET2 KMT2C KMT2D

3.18e-04271463C0036920
Diseaselymphocyte percentage of leukocytes

MPO TET2 RPN1 TERT LEPR THADA LIPA GTF3C1 PTCD1 ZBTB25 PLCL2

4.93e-0466514611EFO_0007993
DiseaseAchromatopsia

PDE6C CNGA3

5.02e-0471462C0152200
DiseaseJoubert syndrome (implicated_via_orthology)

TMEM237 TOGARAM1

5.02e-0471462DOID:0050777 (implicated_via_orthology)
DiseaseCraniosynostosis syndrome

TCF12 ERF

5.02e-0471462cv:C0010278
Diseaseresponse to aromatase inhibitor

CYP2A6 MUC16 CNOT1

5.30e-04321463GO_0061477
Diseaselower urinary tract symptom, benign prostatic hyperplasia

TBX3 HNF1B TERT

5.30e-04321463EFO_0000284, EFO_0008008
Diseasenon-small cell lung carcinoma

CYP2A6 DSCAM TERT BRCA2

5.32e-04751464EFO_0003060
DiseaseMalignant neoplasm of urinary bladder

MPO TERT KMT2C KMT2D BRCA2

6.98e-041411465C0005684
DiseaseLiver Diseases, Parasitic

CYP2A6 KMT2C

8.56e-0491462C0023897
Diseaseplatelet measurement

TCF12 KALRN DOCK8 CHD9 ACAD10 TERT FAR2

1.01e-033151467EFO_0005036
DiseaseProstatic Neoplasms

MPO TET2 CYP2A6 TBX3 HNF1B ERF TERT KMT2C KMT2D BRCA2

1.02e-0361614610C0033578
DiseaseMalignant neoplasm of prostate

MPO TET2 CYP2A6 TBX3 HNF1B ERF TERT KMT2C KMT2D BRCA2

1.02e-0361614610C0376358
Diseasegeneralized epilepsy with febrile seizures plus 2 (implicated_via_orthology)

SCN7A SCN10A

1.07e-03101462DOID:0111294 (implicated_via_orthology)
DiseaseDravet syndrome (implicated_via_orthology)

SCN7A SCN10A

1.07e-03101462DOID:0080422 (implicated_via_orthology)
DiseaseJoubert syndrome (is_implicated_in)

TMEM237 TOGARAM1

1.07e-03101462DOID:0050777 (is_implicated_in)
Diseaseprostate cancer (is_marker_for)

FOXO3 TERT KMT2C KMT2D PHLPP1

1.10e-031561465DOID:10283 (is_marker_for)
Diseasenucleus accumbens volume change measurement

DSCAM MUC16

1.30e-03111462EFO_0021493
Diseasetriglyceride measurement, low density lipoprotein cholesterol measurement

CYP2A6 DNAH10 CELSR2 BRCA2 TP53BP1

1.45e-031661465EFO_0004530, EFO_0004611
DiseaseQRS complex, QRS duration

TKT SCN10A PRKCA

1.45e-03451463EFO_0005054, EFO_0005055
Diseasefibrinogen measurement, tissue plasminogen activator measurement

CHD9 LEPR FNIP1

1.45e-03451463EFO_0004623, EFO_0004791
Diseasenicotine metabolite ratio

CYP2A6 CYP2A7

1.55e-03121462EFO_0007794
Diseasecraniosynostosis (is_implicated_in)

TCF12 ERF

1.55e-03121462DOID:2340 (is_implicated_in)
Diseasechronic kidney disease (implicated_via_orthology)

TERT LEPR

1.55e-03121462DOID:784 (implicated_via_orthology)
Diseasegeneralized epilepsy with febrile seizures plus (implicated_via_orthology)

SCN7A SCN10A

1.55e-03121462DOID:0060170 (implicated_via_orthology)
Diseaseautosomal dominant polycystic kidney disease (implicated_via_orthology)

LATS1 BICC1

2.13e-03141462DOID:898 (implicated_via_orthology)
Diseasetriacylglycerol 48:4 measurement

DSCAM PLD5

2.13e-03141462EFO_0010407
Diseasefibrinogen measurement

CHD9 ACAD10 LEPR LIPA

2.14e-031091464EFO_0004623
Diseasegranulocyte percentage of myeloid white cells

MPO RPN1 DOCK8 CHD9 LEPR THADA

2.23e-032681466EFO_0007997
Diseasetriglyceride measurement, intermediate density lipoprotein measurement

DNAH10 CELSR2 BRCA2 TP53BP1

2.29e-031111464EFO_0004530, EFO_0008595
Diseasemyeloid white cell count

MPO TET2 ERF DNAH10 RPN1 DOCK8 TERT LEPR THADA LIPA GTF3C1 ADGRF5

2.47e-0393714612EFO_0007988
Diseaselow density lipoprotein cholesterol measurement, lipid measurement

CYP2A6 LEPR CELSR2 BRCA2

2.52e-031141464EFO_0004529, EFO_0004611
Diseasetriglycerides in medium VLDL measurement

DNAH10 CELSR2 TP53BP1

2.58e-03551463EFO_0022155
DiseaseColorectal Carcinoma

MPO TET2 CYP2A6 RASGRF2 KALRN ZNF217 KMT2C KCNQ5 PDILT RIC3

2.67e-0370214610C0009402
Diseaseovarian cancer (is_implicated_in)

MUC16 BRCA2 PRKCA

2.72e-03561463DOID:2394 (is_implicated_in)
DiseaseInherited oocyte maturation defect

ASTL TLE6

2.79e-03161462cv:CN238505
DiseaseSynostotic Posterior Plagiocephaly

TCF12 ERF

2.79e-03161462C1833340
DiseaseCraniosynostosis, Type 1

TCF12 ERF

2.79e-03161462C4551902
DiseaseAcrocephaly

TCF12 ERF

2.79e-03161462C0030044
DiseaseTrigonocephaly

TCF12 ERF

2.79e-03161462C0265535
DiseaseScaphycephaly

TCF12 ERF

2.79e-03161462C0265534
DiseaseSynostotic Anterior Plagiocephaly

TCF12 ERF

2.79e-03161462C2931150
DiseaseMetopic synostosis

TCF12 ERF

2.79e-03161462C1860819
DiseaseInborn Errors of Metabolism

LEPR SERPINA7

3.15e-03171462C0025521
DiseaseBrachycephaly

TCF12 ERF

3.15e-03171462C0221356
DiseaseIGF-1 measurement, IGFBP-3 measurement

FOXO3 CELSR2

3.15e-03171462EFO_0004626, EFO_0004627
Diseasemean corpuscular hemoglobin concentration

KALRN RPN1 ZNF217 ACAD10 TERT OR6P1 LEPR RHCE HECW2 C1orf105 PLCL2 ADGRF5 VPS13B

3.42e-03110514613EFO_0004528
DiseaseBrugada syndrome

SCN10A PRKCA

3.93e-03191462MONDO_0015263
Diseasecardiomyopathy (is_implicated_in)

DTNA SRF

3.93e-03191462DOID:0050700 (is_implicated_in)
Diseasecaffeine metabolite measurement

CYP2A6 CYP2A7

3.93e-03191462EFO_0007872
Diseasecystatin C measurement

KALRN FNDC3A ACAD10 DCST1 DNAH1 PDILT FNIP1

3.98e-034021467EFO_0004617
Diseasecreatinine measurement

FOXO3 TET2 SLC52A1 TCF12 DSCAM CHD9 ACAD10 CDH20 CELSR2 PDILT FNIP1 RIC3

4.01e-0399514612EFO_0004518
Diseasecholesterol in large VLDL measurement

DNAH10 CELSR2 TP53BP1

4.14e-03651463EFO_0021902
Diseasecholesterol in very large VLDL measurement

DNAH10 CELSR2 TP53BP1

4.14e-03651463EFO_0022230
DiseaseCraniosynostosis

TCF12 ERF

4.36e-03201462C0010278
Diseaseobesity (implicated_via_orthology)

TCF12 DNAH10 LEPR THADA ADAMTS9

4.41e-032151465DOID:9970 (implicated_via_orthology)
Diseasefree cholesterol measurement, very low density lipoprotein cholesterol measurement

CYP2A6 DNAH10 RHCE CELSR2 TP53BP1

4.41e-032151465EFO_0008317, EFO_0008591
Diseaseplatelet component distribution width

FOXO3 SUPT20H KALRN RPN1 DOCK8 HEATR4 RHCE FAR2 C1orf105 ADGRF5

4.45e-0375514610EFO_0007984
Diseaseovarian neoplasm

MUC16 TERT BRCA2 TP53BP1

4.49e-031341464C0919267
Diseasetuberculosis

CYP2A6 DSCAM LIPA PLD5 VPS13B

4.50e-032161465MONDO_0018076
Diseasetotal lipids in small VLDL

DNAH10 CELSR2 TP53BP1

4.51e-03671463EFO_0022148
Diseasetotal lipids in large VLDL

DNAH10 CELSR2 TP53BP1

4.51e-03671463EFO_0022175
DiseaseBenign Neoplasm

SRF TERT HSF1

4.70e-03681463C0086692
DiseaseNeoplasms

SRF TERT HSF1

4.70e-03681463C0027651
Diseasefree cholesterol in large VLDL measurement

DNAH10 CELSR2 TP53BP1

4.70e-03681463EFO_0022265
DiseaseMalignant neoplasm of ovary

MUC16 TERT BRCA2 TP53BP1

4.86e-031371464C1140680
Diseasemean platelet volume

TET2 TCF12 KALRN RPN1 DOCK8 CHD9 ZNF217 TERT LEPR FAR2 ADGRF5 NIN

4.87e-03102014612EFO_0004584
Diseasecongenital heart disease (implicated_via_orthology)

CHD9 KMT2C KMT2D

4.90e-03691463DOID:1682 (implicated_via_orthology)
DiseaseProstate cancer, familial

HNF1B ITGB8 BRCA2

4.90e-03691463C2931456

Protein segments in the cluster

PeptideGeneStartEntry
LRTTKQQPYHTMESI

VANGL2

406

Q9ULK5
SIKHQATYLSLSNMP

TRHDE

291

Q9UKU6
NYSTMDPVQKAVLSH

ZNF385A

46

Q96PM9
SPEDMKRYLQAHTQS

ERF

306

P50548
ITTNPVQMLHEFSKY

ADAM23

361

O75077
KHVGFATIPRNYTMS

CYP2A6

476

P11509
ATSYGKQTNVLMHFP

APOF

36

Q13790
MFRKIHSIFNSSPQR

C13orf42

1

A0A1B0GVH6
KEMPFTNPLTRSYHT

ACAD10

606

Q6JQN1
KSSTSRPDAYEHTQM

BCAP29

81

Q9UHQ4
PQYRQKILMVQSFSH

CAPN13

106

Q6MZZ7
SALAQNMRHTYLSPF

CELSR2

2146

Q9HCU4
NTYAPTMPFKHSQAT

DNHD1

4071

Q96M86
NPTTTQYASLMHSFI

DYNLRB1

36

Q9NP97
LSRPSTNEMASVNHY

DNAI3

796

Q8IWG1
RRANHVSYKPTMTTT

BICC1

776

Q9H694
INFTMPNTIKHYVHR

DDX27

536

Q96GQ7
INFIKSQSSNMLTPY

ASTL

216

Q6HA08
QINKFLYLHTSERMP

ATG2A

1536

Q2TAZ0
SLNRKYTPVSYMHTA

INTS7

761

Q9NVH2
YQLSQMTFHKIPADS

JAK3

506

P52333
HFSRYSPSPLSMKQL

PDK4

26

Q16654
FTVLHSNPSAYRMFT

HECW2

931

Q9P2P5
YLRVSMSPVLHTQNK

NUP210

1376

Q8TEM1
RPKSTLVYHITSGNM

FAR2

296

Q96K12
LYVNGFTHRSSMPTT

MUC16

12186

Q8WXI7
LHTYLRSKMSQVAPS

NOP56

281

O00567
HTPMLKLSYSTSQEF

FAM171A1

411

Q5VUB5
PQSSKHYQTVFLMRS

KANSL1L

71

A0AUZ9
QNYSMPTSSFRNLLK

PRAMEF17

186

Q5VTA0
QSPMRETPSKAFHQY

KMT2C

4266

Q8NEZ4
LRRQFISYTKMHPNN

KTI12

321

Q96EK9
HTATMLQVKIYDPTN

MGAM2

1001

Q2M2H8
KTFPASNYTVSSRQM

LATS1

16

O95835
VHMYDTVSQIKSPFT

HIPK1

546

Q86Z02
PKNLNMSRLDVYFSH

LIPJ

236

Q5W064
TSNFDRYVHATKMQP

KIAA1109

1786

Q2LD37
RYVHATKMQPQSSGS

KIAA1109

1791

Q2LD37
TFYALSPTMHSQATQ

KCNQ5

701

Q9NR82
PTASTYLHQLTLQKM

LCORL

376

Q8N3X6
YTHVTTMGQRLSQKA

SLC43A1

251

O75387
SMPKYSRQFSLEHVH

HSF1

221

Q00613
FMTKSHQQYTFVNPS

PLXNA2

941

O75051
MSVSKAQSIYGIPHS

LCOR

366

Q96JN0
AMKSSPQIPHQTYSS

MAPK6

701

Q16659
HSPTQDKMVSVFYTI

OR2M2

266

Q96R28
IYLQPSSSHSMDTDK

OR5B2

256

Q96R09
TVSKNNIFMSNSYPR

MPO

711

P05164
HRGTNNLYQMKSTSP

PDE6C

606

P51160
YNSPQFKKTMSTFHN

FBXO39

211

Q8N4B4
SPSYENSLHSLQSRM

TCF12

386

Q99081
FLKYIHRNNVSMPSV

KALRN

1076

O60229
YMPQFQTCSTQTHKI

LEPR

1141

P48357
SPMLIVFHGKYSTIN

GLT8D2

271

Q9H1C3
YTAMPGNTHRKITSF

RIC3

131

Q7Z5B4
TFMYVLPSSFHSTRQ

OR2AG1

256

Q9H205
SYPKHITSNTMAAEF

PARP4

926

Q9UKK3
LFMYLQPQTNHSLDT

OR8J3

256

Q8NGG0
RNSTKVSPQDHMYTF

PTPRQ

1421

Q9UMZ3
NNVYVKSTTMEHPSL

ITGB8

311

P26012
LFMYVQPRSNHSLDT

OR8J1

256

Q8NGP2
RPRAMYTFNHNKIIS

OR6P1

261

Q8NGX9
VYTRSASPKHGFTIM

DCP1B

61

Q8IZD4
NTVTPRLMRHFNYLS

DNAH1

2351

Q9P2D7
KSPQHVMAPTLNFYT

ADAMTS9

456

Q9P2N4
YSQSKMAHSRTSTPL

CHD9

2001

Q3L8U1
KHVGFATIPRNYTMS

CYP2A13

476

Q16696
NTVLTTMHAFPYIKT

DOCK8

1916

Q8NF50
PFYQVSATRNEKMRH

BRCA2

2381

P51587
NNKFSPHASTREYVM

FBXO5

306

Q9UKT4
QAPASRLHLSTQKMY

DCST1

226

Q5T197
QKHYQMSVLESAPIS

CDH20

276

Q9HBT6
KHVVFATIPRNYTMS

CYP2A7

476

P20853
AASSELPHVYMRKQS

CYP2R1

56

Q6VVX0
PKTLSTDSIQYHLQM

FNDC3A

976

Q9Y2H6
SSQSVDMLAKTHPYN

FNIP1

486

Q8TF40
ALFLYSRSPSHSKNM

ITGAV

541

P06756
VPMVFFSSQYRLHRK

HEATR4

46

Q86WZ0
FQTMSSVTNLTPHYF

GALNTL5

151

Q7Z4T8
TRKNHNMASRPLTFT

CEP350

781

Q5VT06
NHPMNKTSASLSLDY

ABCA2

1771

Q9BZC7
NPVHKSGTRYMFTTE

EDEM1

566

Q92611
STIFYQLNKRMPTTH

DTNA

86

Q9Y4J8
RSVSEKNSYHPVSLM

FAM161A

141

Q3B820
KNSYHPVSLMTSFSE

FAM161A

146

Q3B820
KLQNTFRTPVYTTSM

DNAH10

4421

Q8IVF4
YTNFASIPQKMTHLP

SEC24B

1186

O95487
LIESHFINMYTRPKS

CFAP47

1806

Q6ZTR5
SRHPMLYSFQTSLPK

CPT1B

161

Q92523
SKRQSHKYQAEFPMS

LILRA3

371

Q8N6C8
QPLHTYSMKDSVATV

OR1D4

261

P47884
QPLHTYSMKDSVATV

OR1D5

261

P58170
QYSHTSRFPSAMVVT

HNF1B

521

P35680
RFLMVLFHNPSSKQS

PDILT

61

Q8N807
HPSSTYSIRMYAKNR

DSCAM

951

O60469
RMEFPSYTINRKTHI

FAN1

581

Q9Y2M0
IQENKPATFSSMSHY

FOXO3

451

O43524
LVTFSTLYNKMHGTP

RUSC2

281

Q8N2Y8
KVSQFPELTSHTMRF

RUSC2

1091

Q8N2Y8
PLHYTTKMTNSTIKQ

TAAR3P

136

Q9P1P4
PSVSLQQYKNFMSSI

THADA

721

Q6YHU6
FGTQTILNSMHKYQP

TBX3

236

O15119
QPKKSMNSVTRNLYH

SKA1

181

Q96BD8
NHTFPRLNRNKYMVT

PLD5

431

Q8N7P1
TPEMRSYHFRKALSQ

TCAF2

406

A6NFQ2
LFQSIMEHNVSYPKS

PRKCA

546

P17252
SASTPYRQLKRHLSM

NIN

256

Q8N4C6
KNERTPYIMKTSQHF

RASGRF2

1036

O14827
IIFMYPQPKSSHSLN

OR5AL1

271

P0C617
QDMKQPLSHYFINSS

PLCL2

426

Q9UPR0
VHYENNSPFLTITSM

RPN1

216

P04843
PENNTHVALFKMYTS

PGAP1

556

Q75T13
PAQNTFYSRQKHMKL

SI

1696

P14410
KPSQLQSQFRLTYTM

SKIV2L

736

Q15477
TGHVYTFATRKLQPM

SRF

191

P11831
FNTPAMHIAYQSRLS

ACTL7A

191

Q9Y615
MVIKSSHPETYQQRF

ADGRF5

856

Q8IZF2
MSYRMSLHQPKFQTT

C1orf105

111

O95561
FTDRKTHLYTLVMNP

CLGN

221

O14967
FTVSSVVPHNFMYSK

CLEC4C

36

Q8WTT0
FQMLYPATTSKGTTH

CLRN3

161

Q8NCR9
MAKINTQYSHPSRTH

CNGA3

1

Q16281
YDTSYNNKMPLSTHR

C11orf1

101

Q9H5F2
MKRVSIEPNFHSLYS

CNOT1

1136

A5YKK6
YLSHIATEMNQVFSP

ZBTB25

106

P24278
QQMTSDRIHLYTPSS

TMEM237

326

Q96Q45
SSLAHPQRKISMTYV

RHCE

256

P18577
PQRKISMTYVHSAVL

RHCE

261

P18577
LFFHTMRYKSQDPRN

TKT

51

P29401
MFPPTSIYHVFQSRK

SLC52A1

426

Q9NWF4
NPMYIHTSVSQDFSR

SCML2

561

Q9UQR0
MAVNETTNYSSHRKP

SCN10A

281

Q9Y5Y9
QDMTQPLSHYFITSS

PLCH2

326

O75038
SSNMKSPGYQSRHIL

SUPT20H

151

Q8NEM7
HSSQPNATLYKMSSI

SERPINA7

31

P05543
QYSGPRSHFKLFTSM

SEZ6

661

Q53EL9
EYSQSPKMESLSSHR

TP53BP1

521

Q12888
THRDYMVSNPSLITK

UPK1A

116

O00322
TYSKIMNHKNSLTFP

ROCK1

286

Q13464
HSTISLPFKYMQQCT

ZNF844

566

Q08AG5
MNVKSVTKHSYLPRS

ZNF844

586

Q08AG5
MAKPSHSSYVLQQLN

ZBTB1

1

Q9Y2K1
KVFSYNSSLMVHQRT

ZNF852

446

Q6ZMS4
TRLHFTYENLNSKMP

VPS13B

236

Q7Z7G8
PVSYQHLSNSMAQKR

ZNF217

1016

O75362
LHMAYNRLQSFPASK

PHLPP1

1041

O60346
FLTLEHYPMSKQTNT

SCN7A

521

Q01118
AISQYKERMPSVTHS

TOGARAM1

1226

Q9Y4F4
YSKSFGPNSLLMHQV

ZSCAN29

656

Q8IWY8
TDMKKSQVTPNTHIY

PTCD1

576

O75127
RSMEVKPAQASHTNY

GTF3C1

1631

Q12789
RISLVFYQHKSMNEP

TET2

1896

Q6N021
HTYNPKMSLDISAVQ

TOPBP1

991

Q92547
EVTYKNMRFLITHNP

PTP4A1

11

Q93096
SHVSTLTDLQPYMRQ

TERT

761

O14746
VYVTSPLVNNFTMHS

VPS37A

96

Q8NEZ2
EYQFKSQIMSLSHSP

TLE6

456

Q9H808
KESGYNMIHFTPLQT

AGL

151

P35573
RPHTLNSTSMSKAYQ

KMT2D

5351

O14686
NLNMSRVDVYTTHSP

LIPA

271

P38571