Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionextracellular matrix constituent conferring elasticity

FBLN2 FBN1 FBN2

3.01e-0612493GO:0030023
GeneOntologyMolecularFunctionstructural molecule activity conferring elasticity

FBLN2 FBN1 FBN2

4.96e-0614493GO:0097493
GeneOntologyMolecularFunctionlow-density lipoprotein particle receptor activity

LRP1 LRP1B STAB1

7.60e-0616493GO:0005041
GeneOntologyMolecularFunctioncalcium ion binding

FBLN2 FBN1 FBN2 RASGRP3 LALBA LRP1 LRP1B FBN3 NOTCH2 STAB1

1.13e-057494910GO:0005509
GeneOntologyMolecularFunctionlipoprotein particle receptor activity

LRP1 LRP1B STAB1

1.79e-0521493GO:0030228
GeneOntologyMolecularFunctionextracellular matrix structural constituent

FBLN2 FBN1 FBN2 COL6A5 FBN3

9.56e-05188495GO:0005201
GeneOntologyMolecularFunctionGTPase activator activity

RASGRP3 ARHGAP26 SIPA1L2 ARHGAP21 TBC1D20

5.93e-04279495GO:0005096
GeneOntologyMolecularFunctioncargo receptor activity

LRP1 LRP1B STAB1

1.19e-0385493GO:0038024
GeneOntologyMolecularFunctionmethylation-dependent protein binding

PHF20L1 ING2 CHD5

1.32e-0388493GO:0140034
GeneOntologyMolecularFunctionscavenger receptor activity

LRP1 STAB1

1.99e-0327492GO:0005044
GeneOntologyMolecularFunctionmolecular function activator activity

FBN1 FBN2 BICRA RASGRP3 ARHGAP26 WNT9A SIPA1L2 ARHGAP21 TBC1D20

2.77e-031233499GO:0140677
GeneOntologyMolecularFunctionubiquitin conjugating enzyme binding

MARCHF7 DCUN1D3

3.52e-0336492GO:0031624
GeneOntologyMolecularFunctionprotein-disulfide reductase activity

TXNDC2 STAB1

3.52e-0336492GO:0015035
GeneOntologyBiologicalProcesssequestering of TGFbeta in extracellular matrix

FBN1 FBN2

3.17e-054482GO:0035583
GeneOntologyBiologicalProcessnegative regulation of proteolysis

PHF20L1 WNT9A LRP1 RNF34 MARCHF7 BIRC6

1.04e-04326486GO:0045861
GeneOntologyBiologicalProcessnegative regulation of signal transduction by p53 class mediator

ING2 RNF34 MARCHF7

1.18e-0441483GO:1901797
GeneOntologyBiologicalProcessmaintenance of protein location in extracellular region

FBN1 FBN2

1.47e-048482GO:0071694
GeneOntologyBiologicalProcessregulation of signal transduction by p53 class mediator

ING2 CHD5 RNF34 MARCHF7

1.68e-04119484GO:1901796
GeneOntologyCellularComponentmicrofibril

FBN1 FBN2 FBN3

3.40e-0613493GO:0001527
GeneOntologyCellularComponentGBAF complex

BICRA BICRAL

4.81e-0414492GO:0140288
HumanPhenoAbnormal upper to lower segment ratio

FBN1 FBN2

3.14e-053172HP:0012772
HumanPhenoDolichocephaly

FBN1 FBN2 IPO8 BICRA NOTCH2 RUSC2

4.90e-05219176HP:0000268
DomaincEGF

FBLN2 FBN1 FBN2 LRP1 LRP1B FBN3

5.25e-1126496IPR026823
DomaincEGF

FBLN2 FBN1 FBN2 LRP1 LRP1B FBN3

5.25e-1126496PF12662
DomainEGF_CA

FBLN2 FBN1 FBN2 LRP1 LRP1B FBN3 NOTCH2 STAB1

9.47e-10122498SM00179
DomainEGF-like_Ca-bd_dom

FBLN2 FBN1 FBN2 LRP1 LRP1B FBN3 NOTCH2 STAB1

1.08e-09124498IPR001881
DomainEGF_CA

FBLN2 FBN1 FBN2 LRP1 LRP1B FBN3 NOTCH2

2.51e-0986497PF07645
DomainEGF_Ca-bd_CS

FBLN2 FBN1 FBN2 LRP1 LRP1B FBN3 NOTCH2

5.88e-0997497IPR018097
DomainGrowth_fac_rcpt_

FBLN2 FBN1 FBN2 LRP1 LRP1B FBN3 NOTCH2 STAB1

6.67e-09156498IPR009030
DomainEGF_CA

FBLN2 FBN1 FBN2 LRP1 LRP1B FBN3 NOTCH2

6.79e-0999497PS01187
DomainASX_HYDROXYL

FBLN2 FBN1 FBN2 LRP1 LRP1B FBN3 NOTCH2

7.29e-09100497PS00010
DomainEGF-type_Asp/Asn_hydroxyl_site

FBLN2 FBN1 FBN2 LRP1 LRP1B FBN3 NOTCH2

1.10e-08106497IPR000152
DomainFBN

FBN1 FBN2 FBN3

1.70e-083493IPR011398
DomainEGF_3

FBLN2 FBN1 FBN2 LRP1 LRP1B FBN3 NOTCH2 STAB1

1.61e-07235498PS50026
DomainEGF

FBLN2 FBN1 FBN2 LRP1 LRP1B FBN3 NOTCH2 STAB1

1.61e-07235498SM00181
DomainEGF-like_dom

FBLN2 FBN1 FBN2 LRP1 LRP1B FBN3 NOTCH2 STAB1

2.51e-07249498IPR000742
DomainEGF_1

FBLN2 FBN1 FBN2 LRP1 LRP1B FBN3 NOTCH2 STAB1

3.01e-07255498PS00022
DomainEGF-like_CS

FBLN2 FBN1 FBN2 LRP1 LRP1B FBN3 NOTCH2 STAB1

3.59e-07261498IPR013032
DomainEGF_2

FBLN2 FBN1 FBN2 LRP1 LRP1B FBN3 NOTCH2 STAB1

4.03e-07265498PS01186
DomainTB

FBN1 FBN2 FBN3

5.90e-077493PF00683
Domain-

FBN1 FBN2 FBN3

9.42e-0784933.90.290.10
DomainTB

FBN1 FBN2 FBN3

1.41e-069493PS51364
DomainTB_dom

FBN1 FBN2 FBN3

1.41e-069493IPR017878
DomainDUF5050

LRP1 LRP1B

6.74e-062492IPR032485
DomainDUF5050

LRP1 LRP1B

6.74e-062492PF16472
DomainGSCR1_dom

BICRA BICRAL

6.74e-062492IPR015671
DomainGLTSCR1

BICRA BICRAL

6.74e-062492PF15249
DomainEGF

LRP1 LRP1B FBN3 NOTCH2 STAB1

1.94e-05126495PF00008
DomainhEGF

FBN2 FBN3 NOTCH2

5.31e-0528493PF12661
Domain-

PHF20L1 ING2 RNF141 CHD5 RNF34 MARCHF7 TRIM10

1.59e-044494973.30.40.10
DomainZnf_RING/FYVE/PHD

PHF20L1 ING2 RNF141 CHD5 RNF34 MARCHF7 TRIM10

1.82e-04459497IPR013083
DomainZnf_FYVE_PHD

PHF20L1 ING2 CHD5 RNF34

5.93e-04147494IPR011011
DomainLdl_recept_b

LRP1 LRP1B

6.01e-0414492PF00058
DomainLDLRB

LRP1 LRP1B

6.01e-0414492PS51120
DomainZinc_finger_PHD-type_CS

PHF20L1 ING2 CHD5

6.61e-0465493IPR019786
DomainLY

LRP1 LRP1B

6.93e-0415492SM00135
DomainLDLR_classB_rpt

LRP1 LRP1B

6.93e-0415492IPR000033
DomainZnf_RING

RNF141 CHD5 RNF34 MARCHF7 TRIM10

1.60e-03326495IPR001841
DomainZF_PHD_1

PHF20L1 ING2 CHD5

2.04e-0396493PS01359
Domain-

LRP1 LRP1B

4.70e-03394922.120.10.30
DomainLDLR_class-A_CS

LRP1 LRP1B

4.94e-0340492IPR023415
DomainLdl_recept_a

LRP1 LRP1B

6.21e-0345492PF00057
Domain-

LRP1 LRP1B

6.48e-03464924.10.400.10
Domain6-blade_b-propeller_TolB-like

LRP1 LRP1B

6.48e-0346492IPR011042
DomainLDLRA_1

LRP1 LRP1B

7.04e-0348492PS01209
DomainLDLRA_2

LRP1 LRP1B

7.33e-0349492PS50068
DomainLDrepeatLR_classA_rpt

LRP1 LRP1B

7.33e-0349492IPR002172
DomainLDLa

LRP1 LRP1B

7.33e-0349492SM00192
PathwayREACTOME_MOLECULES_ASSOCIATED_WITH_ELASTIC_FIBRES

FBLN2 FBN1 FBN2 FBN3

2.23e-0637364M27134
PathwayREACTOME_ELASTIC_FIBRE_FORMATION

FBLN2 FBN1 FBN2 FBN3

4.52e-0644364M26969
PathwayWP_HYPOTHESIZED_PATHWAYS_IN_PATHOGENESIS_OF_CARDIOVASCULAR_DISEASE

FBN1 FBN2 FBN3

3.38e-0525363M39713
PathwayREACTOME_MOLECULES_ASSOCIATED_WITH_ELASTIC_FIBRES

FBLN2 FBN1 FBN2

7.21e-0532363MM14854
PathwayREACTOME_ELASTIC_FIBRE_FORMATION

FBLN2 FBN1 FBN2

1.31e-0439363MM14601
PathwayREACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX

FBN1 FBN2 COL6A5 FBN3

4.29e-04140364M587
PathwayREACTOME_RHOJ_GTPASE_CYCLE

ARHGAP26 ARHGAP21

7.44e-0416362MM15605
Pubmed

Heparin/heparan sulfate controls fibrillin-1, -2 and -3 self-interactions in microfibril assembly.

FBN1 FBN2 FBN3

1.19e-08451325034023
Pubmed

Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins.

P2RX2 LRP1 TNFRSF1A LRP1B NOTCH2

3.95e-0710151523382219
Pubmed

Homo- and heterotypic fibrillin-1 and -2 interactions constitute the basis for the assembly of microfibrils.

FBN1 FBN2

2.11e-06251212399449
Pubmed

Fibrillin-1 and fibrillin-2 are essential for formation of thick oxytalan fibers in human nonpigmented ciliary epithelial cells in vitro.

FBN1 FBN2

2.11e-06251221851253
Pubmed

Fibrillins can co-assemble in fibrils, but fibrillin fibril composition displays cell-specific differences.

FBN1 FBN2

2.11e-06251212429739
Pubmed

Striking differences of LDL receptor-related protein 1B expression in mouse and human.

LRP1 LRP1B

2.11e-06251215963947
Pubmed

Confocal laser scanning analysis of the association of fibulin-2 with fibrillin-1 and fibronectin define different stages of skin regeneration.

FBLN2 FBN1

2.11e-0625129886271
Pubmed

New Evidence Supporting the Role of FBN1 in the Development of Adolescent Idiopathic Scoliosis.

FBN1 FBN2

2.11e-06251230044367
Pubmed

Material and mechanical properties of bones deficient for fibrillin-1 or fibrillin-2 microfibrils.

FBN1 FBN2

2.11e-06251221440062
Pubmed

MAGP-2 has multiple binding regions on fibrillins and has covalent periodic association with fibrillin-containing microfibrils.

FBN1 FBN2

2.11e-06251215131124
Pubmed

Fibrillin-1 and fibrillin-2 in human embryonic and early fetal development.

FBN1 FBN2

2.11e-06251212524050
Pubmed

Microfibril structure masks fibrillin-2 in postnatal tissues.

FBN1 FBN2

2.11e-06251220404337
Pubmed

Fibrillln mutations in Marfan syndrome and related phenotypes.

FBN1 FBN2

2.11e-0625128791520
Pubmed

Structure and expression of fibrillin-2, a novel microfibrillar component preferentially located in elastic matrices.

FBN1 FBN2

2.11e-0625128120105
Pubmed

The fibrillinopathies: New insights with focus on the paradigm of opposing phenotypes for both FBN1 and FBN2.

FBN1 FBN2

2.11e-06251235419902
Pubmed

Fibrillin genes map to regions of conserved mouse/human synteny on mouse chromosomes 2 and 18.

FBN1 FBN2

2.11e-0625128307578
Pubmed

Fibrillin assembly: dimer formation mediated by amino-terminal sequences.

FBN1 FBN2

2.11e-06251210504303
Pubmed

Three novel mutations of the fibrillin-1 gene and ten single nucleotide polymorphisms of the fibrillin-3 gene in Marfan syndrome patients.

FBN1 FBN3

2.11e-06251215221638
Pubmed

Developmental expression of fibrillin genes suggests heterogeneity of extracellular microfibrils.

FBN1 FBN2

2.11e-0625127744963
Pubmed

Fibrillin microfibrils in bone physiology.

FBN1 FBN2

2.11e-06251226408953
Pubmed

Novel long noncoding RNAs upregulation may have synergistic effects on the CYP24A1 and PFDN4 biomarker role in human colorectal cancer.

CYP24A1 PFDN4

2.11e-06251232743796
Pubmed

Arg-Gly-Asp-containing domains of fibrillins-1 and -2 distinctly regulate lung fibroblast migration.

FBN1 FBN2

2.11e-06251218006876
Pubmed

Rare variants in FBN1 and FBN2 are associated with severe adolescent idiopathic scoliosis.

FBN1 FBN2

2.11e-06251224833718
Pubmed

Fibrillin-1 and fibulin-2 interact and are colocalized in some tissues.

FBLN2 FBN1

2.11e-0625128702639
Pubmed

Exome sequencing identified new mutations in a Marfan syndrome family.

FBN1 LRP1

2.11e-06251224484584
Pubmed

Nonselective assembly of fibrillin 1 and fibrillin 2 in the rodent ocular zonule and in cultured cells: implications for Marfan syndrome.

FBN1 FBN2

2.11e-06251224265020
Pubmed

In vivo studies of mutant fibrillin-1 microfibrils.

FBN1 FBN2

2.11e-06251220529844
Pubmed

Immunohistochemical expression of fibrillin-1 and fibrillin-2 during tooth development.

FBN1 FBN2

2.11e-06251225524144
Pubmed

Fibrillin-1 mutations causing Weill-Marchesani syndrome and acromicric and geleophysic dysplasias disrupt heparan sulfate interactions.

FBN1 FBN2

2.11e-06251223133647
Pubmed

Fibrillins 1 and 2 perform partially overlapping functions during aortic development.

FBN1 FBN2

2.11e-06251216407178
Pubmed

Linkage of Marfan syndrome and a phenotypically related disorder to two different fibrillin genes.

FBN1 FBN2

2.11e-0625121852206
Pubmed

N-terminal domains of fibrillin 1 and fibrillin 2 direct the formation of homodimers: a possible first step in microfibril assembly.

FBN1 FBN2

2.11e-06251210359653
Pubmed

Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation.

FBN1 FBN2 RASGRP3 LRP1

3.71e-067151433541421
Pubmed

Interaction of tropoelastin with the amino-terminal domains of fibrillin-1 and fibrillin-2 suggests a role for the fibrillins in elastic fiber assembly.

FBN1 FBN2

6.32e-06351210825173
Pubmed

Adamts10 inactivation in mice leads to persistence of ocular microfibrils subsequent to reduced fibrillin-2 cleavage.

FBN1 FBN2

6.32e-06351230201140
Pubmed

TNF is a key mediator of septic encephalopathy acting through its receptor, TNF receptor-1.

FBN1 TNFRSF1A

6.32e-06351217884256
Pubmed

Fibrillin-1 and -2 differentially modulate endogenous TGF-β and BMP bioavailability during bone formation.

FBN1 FBN2

6.32e-06351220855508
Pubmed

Latent transforming growth factor beta-binding protein 1 interacts with fibrillin and is a microfibril-associated protein.

FBN1 FBN2

1.26e-05451212429738
Pubmed

Human eye development is characterized by coordinated expression of fibrillin isoforms.

FBN1 FBN2

1.26e-05451225406291
Pubmed

Extracellular microfibrils control osteoblast-supported osteoclastogenesis by restricting TGF{beta} stimulation of RANKL production.

FBN1 FBN2

1.26e-05451220729550
Pubmed

Comprehensive genetic analysis of relevant four genes in 49 patients with Marfan syndrome or Marfan-related phenotypes.

FBN1 FBN2

1.26e-05451216835936
Pubmed

LRP1 induces anti-PD-1 resistance by modulating the DLL4-NOTCH2-CCL2 axis and redirecting M2-like macrophage polarisation in bladder cancer.

LRP1 NOTCH2

1.26e-05451238462037
Pubmed

Fibulin-2 and fibulin-5 alterations in tsk mice associated with disorganized hypodermal elastic fibers and skin tethering.

FBLN2 FBN1

1.26e-05451215610515
Pubmed

The low-density lipoprotein receptor-related protein is a pro-survival receptor in Schwann cells: possible implications in peripheral nerve injury.

LRP1 TNFRSF1A

1.26e-05451217065459
Pubmed

Characterization of Microfibrillar-associated Protein 4 (MFAP4) as a Tropoelastin- and Fibrillin-binding Protein Involved in Elastic Fiber Formation.

FBN1 FBN2

2.10e-05551226601954
Pubmed

TNIP1, SLC15A4, ETS1, RasGRP3 and IKZF1 are associated with clinical features of systemic lupus erythematosus in a Chinese Han population.

RASGRP3 IKZF1

2.10e-05551220516000
Pubmed

Relaxin regulates fibrillin 2, but not fibrillin 1, mRNA and protein expression by human dermal fibroblasts and murine fetal skin.

FBN1 FBN2

2.10e-05551212590922
Pubmed

Fibrillin-1 interactions with fibulins depend on the first hybrid domain and provide an adaptor function to tropoelastin.

FBN1 FBN2

2.10e-05551217255108
Pubmed

POGLUT2 and POGLUT3 O-glucosylate multiple EGF repeats in fibrillin-1, -2, and LTBP1 and promote secretion of fibrillin-1.

FBN1 FBN2

2.10e-05551234411563
Pubmed

Development, composition, and structural arrangements of the ciliary zonule of the mouse.

FBN1 FBN2

2.10e-05551223493297
Pubmed

Latent transforming growth factor beta-binding proteins and fibulins compete for fibrillin-1 and exhibit exquisite specificities in binding sites.

FBLN2 FBN1

3.15e-05651219349279
Pubmed

Of mice and Marfan: genetic linkage analyses of the fibrillin genes, Fbn1 and Fbn2, in the mouse genome.

FBN1 FBN2

3.15e-0565127873879
Pubmed

Regulation of limb patterning by extracellular microfibrils.

FBN1 FBN2

4.41e-05751211470817
Pubmed

Comparative proteomic analysis of supportive and unsupportive extracellular matrix substrates for human embryonic stem cell maintenance.

FBLN2 FBN1 FBN2

5.55e-055051323658023
Pubmed

Putative functions of extracellular matrix glycoproteins in secondary palate morphogenesis.

FBN1 FBN2

5.87e-05851223055981
Pubmed

Adamts17 is involved in skeletogenesis through modulation of BMP-Smad1/5/8 pathway.

FBN1 FBN2

5.87e-05851231201465
Pubmed

EMILIN proteins are novel extracellular constituents of the dentin-pulp complex.

FBLN2 FBN1

5.87e-05851232948785
Pubmed

Targeting of bone morphogenetic protein growth factor complexes to fibrillin.

FBN1 FBN2

5.87e-05851218339631
Pubmed

Regulation of canonical Wnt signalling by the ciliopathy protein MKS1 and the E2 ubiquitin-conjugating enzyme UBE2E1.

RNF34 LRP1B

7.54e-05951235170427
Pubmed

Microfibril-associated glycoprotein-2 interacts with fibrillin-1 and fibrillin-2 suggesting a role for MAGP-2 in elastic fiber assembly.

FBN1 FBN2

7.54e-05951212122015
Pubmed

Poglut2/3 double knockout in mice results in neonatal lethality with reduced levels of fibrillin in lung tissues.

FBN1 FBN2

7.54e-05951238844137
Pubmed

Limb- and tendon-specific Adamtsl2 deletion identifies a role for ADAMTSL2 in tendon growth in a mouse model for geleophysic dysplasia.

FBN1 FBN2

9.42e-051051230738849
Pubmed

LRP2 mediates folate uptake in the developing neural tube.

LRP1 LRP1B

1.15e-041151224639464
Pubmed

Identification of Stk6/STK15 as a candidate low-penetrance tumor-susceptibility gene in mouse and human.

CYP24A1 PFDN4

1.15e-041151212881723
Pubmed

Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.

FBLN2 FBN1 FBN2 COL6A5

1.29e-0417551428071719
Pubmed

A distinct transcriptome characterizes neural crest-derived cells at the migratory wavefront during enteric nervous system development.

FBN1 FBN2

1.38e-041251236779913
Pubmed

Disruption of murine Adamtsl4 results in zonular fiber detachment from the lens and in retinal pigment epithelium dedifferentiation.

FBN1 FBN2

1.38e-041251226405179
Pubmed

Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.

BICRA TRO KIAA0232 ELF3 TNFRSF1A ACSF2 ATP8B2 NOTCH2

1.45e-04106151833845483
Pubmed

Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer.

FBN1 FBN2 LRP1 NOTCH2

1.56e-0418451432908313
Pubmed

Protein interactome reveals converging molecular pathways among autism disorders.

FBLN2 FBN1 KIAA0232 NOTCH2 RUSC2 STAB1

1.65e-0456051621653829
Pubmed

A non-canonical BRD9-containing BAF chromatin remodeling complex regulates naive pluripotency in mouse embryonic stem cells.

BICRA BICRAL

1.90e-041451230510198
Pubmed

Normal development and fertility of knockout mice lacking the tumor suppressor gene LRP1b suggest functional compensation by LRP1.

LRP1 LRP1B

1.90e-041451215082773
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

BICRA ARHGAP26 CHD5 SIPA1L2 BIRC6 ARHGAP21 NOTCH2 PPP1R16A

1.92e-04110551835748872
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

FBN2 BICRA CHD5 LRP1 ELF3 BICRAL SIPA1L2 NOTCH2

2.05e-04111651831753913
Pubmed

The human cytoplasmic dynein interactome reveals novel activators of motility.

FBN2 IPO8 KIAA0232 PFDN4 SIPA1L2 LRP1B ARHGAP21

2.36e-0485351728718761
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

PRPF31 KIAA0232 CCSER2 SIPA1L2 ARHGAP21 NOTCH2 RUSC2

2.49e-0486151736931259
Pubmed

Role of TNF ligand and receptor family in the lymphoid organogenesis defined by gene targeting.

IKZF1 TNFRSF1A

2.50e-041651210687308
Pubmed

Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain.

KIAA0232 BICRAL STAB1

2.51e-04835139039502
Pubmed

Comprehensive proteomic characterization of stem cell-derived extracellular matrices.

FBLN2 FBN1 FBN2

2.79e-048651328327460
Pubmed

Proteolysis of fibrillin-2 microfibrils is essential for normal skeletal development.

FBN1 FBN2

3.18e-041851235503090
Pubmed

Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus.

RASGRP3 IKZF1

3.18e-041851219838193
Pubmed

ADAMTS18-fibronectin interaction regulates the morphology of liver sinusoidal endothelial cells.

FBN1 FBN2

3.18e-041851239040056
Pubmed

USP53 plays an antitumor role in hepatocellular carcinoma through deubiquitination of cytochrome c.

PRPF31 MCM7 NOTCH2

3.19e-049051335654790
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

TRO KIAA0232 SIPA1L2 ARHGAP21 RUSC2

3.23e-0440751512693553
Pubmed

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.

CYP24A1 TNFRSF1A ALPK2

3.29e-049151321833088
Pubmed

Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

KIAA0232 CHD5 BIRC6 STAB1

3.36e-0422551412168954
Pubmed

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.

LRP1 MCM7 ARL14EP BIRC6 ARHGAP21

3.65e-0441851534709266
Pubmed

MESD is essential for apical localization of megalin/LRP2 in the visceral endoderm.

LRP1 LRP1B

4.35e-042151221337463
Pubmed

Systematic analysis of dimeric E3-RING interactions reveals increased combinatorial complexity in human ubiquitination networks.

RNF141 RNF34 MARCHF7

5.01e-0410551322493164
Pubmed

Identification of multi-SH3 domain-containing protein interactome in pancreatic cancer: a yeast two-hybrid approach.

MARCHF7 BIRC6 NOTCH2

5.15e-0410651318654987
Pubmed

The protein interaction landscape of the human CMGC kinase group.

PRPF31 KIAA0232 ARHGAP26 MCM7 PFDN4 SIPA1L2

5.23e-0469551623602568
Pubmed

High-density polymorphisms analysis of 23 candidate genes for association with bone mineral density.

CYP24A1 TNFRSF1A

5.23e-042351220654748
Pubmed

Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population.

CYP24A1 PFDN4

6.19e-042551223042114
Pubmed

Adamts18 modulates the development of the aortic arch and common carotid artery.

FBN1 FBN2

6.70e-042651234189436
Pubmed

Glioma tumor suppressor candidate region gene 1 (GLTSCR1) and its paralog GLTSCR1-like form SWI/SNF chromatin remodeling subcomplexes.

BICRA BICRAL

7.23e-042751229374058
Pubmed

Structure and evolution of the Smith-Magenis syndrome repeat gene clusters, SMS-REPs.

FAM106C FAM106A

8.35e-042951211997339
Pubmed

ADAMTS18 Deficiency Leads to Pulmonary Hypoplasia and Bronchial Microfibril Accumulation.

FBN1 FBN2

8.93e-043051232882513
Pubmed

Heritable Thoracic Aortic Disease Overview

FBN1 FBN2

8.93e-043051220301299
Pubmed

TBX1 is required for normal stria vascularis and semicircular canal development.

FBN1 STAB1

9.54e-043151231550482
Pubmed

Adamtsl2 deletion results in bronchial fibrillin microfibril accumulation and bronchial epithelial dysplasia--a novel mouse model providing insights into geleophysic dysplasia.

FBN1 FBN2

9.54e-043151225762570
InteractionZNF408 interactions

PRPF31 FBLN2 FBN1 FBN2 KIAA0232 LRP1B NOTCH2

6.65e-08145507int:ZNF408
InteractionZFP41 interactions

FBN1 FBN2 LRP1 LRP1B NOTCH2

2.91e-0757505int:ZFP41
InteractionNTN5 interactions

FBN1 FBN2 LRP1B NOTCH2

3.43e-0724504int:NTN5
InteractionFOXD4L6 interactions

FBN2 KIAA0232 LRP1B NOTCH2

6.54e-0649504int:FOXD4L6
InteractionHRG interactions

FBN1 FBN2 TNFRSF1A LRP1B

1.79e-0563504int:HRG
InteractionSLMAP interactions

ARHGAP26 CCSER2 PFDN4 TNFRSF1A ARHGAP21

3.35e-05149505int:SLMAP
InteractionELN interactions

FBLN2 FBN1 FBN2

5.02e-0529503int:ELN
InteractionLTBP1 interactions

FBLN2 FBN1 FBN2 NOTCH2

7.98e-0592504int:LTBP1
InteractionZNF594 interactions

FBLN2 NOTCH2

1.26e-047502int:ZNF594
GeneFamilyLow density lipoprotein receptors

LRP1 LRP1B

2.80e-0413352634
GeneFamilyPHD finger proteins

PHF20L1 ING2 CHD5

6.96e-049035388
GeneFamilyRing finger proteins

RNF141 RNF34 MARCHF7 TRIM10

1.89e-0327535458
GeneFamilyRho GTPase activating proteins|BCH domain containing

ARHGAP26 ARHGAP21

4.21e-0350352721
GeneFamilyArmadillo repeat containing|Protein phosphatase 1 regulatory subunits

MCM7 IKZF1 PPP1R16A

5.10e-03181353694
CoexpressionHALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION

FBLN2 FBN1 FBN2 LRP1 MCM7 NOTCH2

2.20e-06200506M5930
CoexpressionGSE4984_UNTREATED_VS_VEHICLE_CTRL_TREATED_DC_UP

RASGRP3 RNF34 TNFRSF1A SIPA1L2 TBC1D20

1.16e-05155505M6500
CoexpressionGSE19941_UNSTIM_VS_LPS_STIM_IL10_KO_MACROPHAGE_UP

TRO LRP1 MARCHF7 TNFRSF1A TBC1D20

3.85e-05199505M8105
ToppCell3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.2.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FBLN2 FBN1 P2RX2 LRP1 ATP8B2

2.90e-06195515f54bc4454270ff06e85596f98199372b50d0179f
ToppCellCaecum-(6)_Macrophage-(61)_LYVE1_Macrophage|Caecum / shred on region, Cell_type, and subtype

NWD1 LRP1 SIPA1L2 RUSC2 STAB1

3.13e-06198515e684c3934c163aef4d284b69435832d2c9614f2a
ToppCellCaecum-Macrophage-LYVE1_Macrophage|Caecum / Region, Cell class and subclass

NWD1 LRP1 SIPA1L2 RUSC2 STAB1

3.13e-06198515a92c0cacb775aca6bbb302bd9e22c081a112a44d
ToppCellControl_saline-Endothelial-Endothelial-Vein|Control_saline / Treatment groups by lineage, cell group, cell type

FBLN2 FBN1 TNFRSF1A LRP1B STAB1

3.28e-06200515e5f876910bc8cb390d9b46a48d9b6d4d57235551
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Myeloid-Monocytic-Nonclassical_Monocyte-Mono_c4-CD14-CD16|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

SIPA1L2 DCUN1D3 RUSC2 STAB1

2.49e-05148514fd0d8386b94adb1bdc993fbb44d2d87852bfd7f0
ToppCellPND01-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_prolif|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

BICRA TRO MCM7 TNFRSF1A

3.06e-05156514895927228c93cd090303984c5be6ebfb59ed6f3a
ToppCellE12.5-Endothelial-lymphatic_endothelial_cell-endothelial_cell_of_lymphatic_vessel|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

RNF141 RASGRP3 IKZF1 STAB1

3.63e-05163514c21114826bee1b05b411984326fef6b6e0d05316
ToppCellE12.5-Endothelial-lymphatic_endothelial_cell|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

RNF141 RASGRP3 IKZF1 STAB1

3.63e-051635145d49414432db259a19df50d7944581d00b69f537
ToppCellfacs|World / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BICRA BIRC6 NOTCH2 TBC1D20

4.38e-05171514c9990bc041a632b2f7bbebbfe737772c423d7027
ToppCell3'-Broncho-tracheal-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FBLN2 FBN1 LRP1 ATP8B2

4.48e-05172514e37c0b5b547a7345179ab258dd2141fec7064c17
ToppCellfacs|World / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RNF141 BIRC6 NOTCH2 TBC1D20

4.48e-05172514a2d0a64ebf09d219a07d6bbad1056bad6d46b9be
ToppCellPBMC-Severe-Myeloid-cDC-cDC-cDC_12|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

FBLN2 MCM7 ACSF2 LRP1B

4.58e-05173514a55f310c533432e9e26e400026a5b47245152976
ToppCellPBMC-Severe-Myeloid-cDC-cDC-cDC_12|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

FBLN2 MCM7 ACSF2 LRP1B

4.58e-051735149c7386bf0a899882c733f0b4921a96afde032a7d
ToppCell343B-Fibroblasts-Fibroblast-A_(Fibroblast_progenitors)-|343B / Donor, Lineage, Cell class and subclass (all cells)

FBLN2 FBN1 LRP1 LRP1B

4.90e-051765142e94bbe17c0bb65dc58b4ebc0cb829258bd7373b
ToppCell343B-Fibroblasts-Fibroblast-A_(Fibroblast_progenitors)|343B / Donor, Lineage, Cell class and subclass (all cells)

FBLN2 FBN1 LRP1 LRP1B

4.90e-05176514f33ab41d121b59d871ad7d48ca021524a027d2ef
ToppCellkidney_cells-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FBLN2 FAM106A RASGRP3 STAB1

5.01e-05177514227d4f423b00be2e0c5797e2c5275d342e69a0f4
ToppCellkidney_cells-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FBLN2 FAM106A RASGRP3 STAB1

5.01e-0517751466ffa279147961080c104242a08b176e301d80e3
ToppCellkidney_cells-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex-lymphatic_endothelial_cell_of_renal_cortex|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FBLN2 FAM106A RASGRP3 STAB1

5.01e-051775140cbf54608d2ba0a0500af142f2029fe5e118c3c2
ToppCellfacs-Kidney-nan-24m-Mesenchymal|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBN1 COL6A5 MCM7 TRIM10

5.35e-05180514f9f8245cbcdea18c15e2976c85b72c6807309787
ToppCellfacs-Kidney-nan-24m-Mesenchymal-kidney_interstitial_fibroblast|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBLN2 FBN1 COL6A5 MCM7

5.46e-05181514c7f5aedcb74c21fb587a95a16d700e2a38a380ee
ToppCellfacs-Kidney-nan-24m-Mesenchymal-kidney_interstitial_fibroblast|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBLN2 FBN1 COL6A5 MCM7

5.46e-051815140ec9621a078d004bbd25a587757d24b5cf162959
ToppCell3'-Broncho-tracheal-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.2.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FBLN2 FBN1 P2RX2 LRP1

5.58e-05182514d179b5deb07c20d49eb6c58d5a65904f8921de3a
ToppCellControl-Endothelial-Endothelial-Alv_Cap|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

RASGRP3 SIPA1L2 ARHGAP21 TBC1D20

6.20e-05187514ea9d34bcd3bd1f36745846309ede349773de501a
ToppCelldroplet-Lung-1m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l17|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FBLN2 FBN1 TRO WNT9A

6.20e-05187514ed7ab4cf4629d96dad5c74d536fc428d0a8d4eb9
ToppCellkidney_cells-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FBLN2 FBN1 WNT9A LRP1

6.33e-05188514c32d023a69b6da79687ff8fa7485e7499db57046
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FBLN2 FBN1 WNT9A LRP1

6.33e-05188514ce85a56ac27a6432421dde93a1bafa8b943244b9
ToppCellkidney_cells-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FBLN2 FBN1 WNT9A LRP1

6.33e-051885141cd5a4d744bd3777246958ea5eb94388a5cbad81
ToppCellfacs-GAT-Fat-24m-Mesenchymal|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBLN2 FBN1 LRP1 COL6A5

6.59e-051905143720e64129f3f3268b1dc14031a76f41c38241c2
ToppCellfacs-GAT-Fat-24m-Mesenchymal-mesenchymal_progenitor|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBLN2 FBN1 LRP1 COL6A5

6.59e-0519051473a50426f972f08f9bb525ad5c0b774187ab5d6a
ToppCellfacs-GAT-Fat-24m-Mesenchymal-mesenchymal_stem_cell_of_adipose|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBLN2 FBN1 LRP1 COL6A5

6.59e-05190514b55cf1fb586b724295b7b038483249847bb344fc
ToppCelldroplet-Kidney-KIDNEY-30m-Mesenchymal-fibroblast|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBLN2 FBN1 LRP1 COL6A5

6.87e-05192514853a930e0641ffb50cbb4cef5837c70d75c3fc39
ToppCellfacs-Lung-nan-3m-Mesenchymal-Adventitial_Fibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBLN2 FBN1 WNT9A LRP1

6.87e-05192514a2c31390da4962bda9a936470b0b68fa1f5d47d1
ToppCellfacs-Lung-nan-3m-Mesenchymal-adventitial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBLN2 FBN1 WNT9A LRP1

6.87e-05192514eeab1cef7c36ae824381952c5b2c982368c379fd
ToppCelldroplet-Kidney-KIDNEY-30m-Mesenchymal-Stroma____fibroblast|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBLN2 FBN1 LRP1 COL6A5

6.87e-05192514d2c03490c5e835d0f0a732803093c64b8d4b4029
ToppCelldroplet-Kidney-KIDNEY-30m-Mesenchymal|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBLN2 FBN1 LRP1 COL6A5

6.87e-0519251449281626ecad0456fdbded2378b7028d7b589686
ToppCellChildren_(3_yrs)-Immune-monocyte-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

FBN2 ARHGAP26 IKZF1 NOTCH2

7.01e-0519351458e1930a1d80ad3729ab9604ac8ebf7308232a3d
ToppCellLA|World / Chamber and Cluster_Paper

FBLN2 FBN1 LRP1 LRP1B

7.01e-05193514d4bf89437216baf489ea0239136dcedf3b6714af
ToppCellfacs-Kidney-nan-18m-Mesenchymal-mesangial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NWD1 FBLN2 FBN1 LRP1

7.15e-05194514bbc625b4cc53bb7d6254fde287258e51f9171572
ToppCellIPF-Stromal-Fibroblast|Stromal / Disease state, Lineage and Cell class

FBLN2 FBN1 WNT9A LRP1

7.15e-05194514da3e1d39575969a069ef43e552afe94b2f441d0b
ToppCellfacs-Kidney-nan-18m-Mesenchymal|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NWD1 FBLN2 FBN1 LRP1

7.15e-05194514fcd5e9238d299c41f0bf9693b56cd8c900d2112b
ToppCellControl-Classical_Monocyte|Control / Disease condition and Cell class

FBN2 ARHGAP26 LRP1 STAB1

7.15e-051945149e33e1b54b4114f9e6981819834bb796ed7192b5
ToppCellCOVID-19-Heart-Fib_2|Heart / Disease (COVID-19 only), tissue and cell type

FBLN2 FBN1 LRP1 NOTCH2

7.15e-05194514d91c9f2ec47319051fc398320693fddbe8bbd4d6
ToppCellfacs-Kidney-nan-18m-Mesenchymal-mesangial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NWD1 FBLN2 FBN1 LRP1

7.15e-051945146afc21c5fec30ab8e373e3e46ab7866204c805b6
ToppCellCOVID-19-Heart-Fib_1|Heart / Disease (COVID-19 only), tissue and cell type

FBLN2 FBN1 LRP1 NOTCH2

7.29e-05195514f423baa36ac7cdc383c033e35a7d17e6bf913323
ToppCellfacs-Heart-LA-3m-Mesenchymal|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBLN2 FBN1 LRP1 NOTCH2

7.29e-0519551479a6e8e6de040ff07539e8901fc407363a50e355
ToppCell3'-GW_trimst-1-SmallIntestine-Endothelial-blood_vessel_EC-Fetal_venous_EC|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FBLN2 FBN1 RASGRP3 STAB1

7.29e-05195514752a100297c26732e12bbbf3ab27a2bd4f5ea06d
ToppCellfacs-Heart-LA-3m-Mesenchymal-fibroblast_of_cardiac_tissue|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBLN2 FBN1 LRP1 NOTCH2

7.44e-05196514ad1838dabd043cb140260843e3527d8c7d58850e
ToppCellfacs-Heart-LA-3m-Mesenchymal-fibroblast_of_cardiac_tissue|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBLN2 FBN1 LRP1 NOTCH2

7.44e-05196514cbc15c0769016fe9972445169029bd8d14a7e6ef
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ARHGAP26 LRP1 IKZF1 STAB1

7.58e-051975148af4a1e35ce9fb4ea3d26ab619599efb7eac43a5
ToppCell(5)_Fibroblasts-(5)_Fibroblast-E|(5)_Fibroblasts / Lung cell shreds - cell class (v4) and cell subclass (v4)

FBLN2 FBN1 ING2 LRP1

7.58e-051975149b1c1d72c5a8c90d71ae31e4c198d2276872eaa0
ToppCellfacs-Heart-LA-3m|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBLN2 FBN1 LRP1 NOTCH2

7.58e-051975142a91738cb6d7588869dd00deeea0cbbc2d6aa34d
ToppCell3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.2.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FBLN2 FBN1 P2RX2 LRP1

7.58e-05197514c747c496ac090309b7f8a3e9d840928f12c83f2f
ToppCellsevere-HLA-DR+_CD83+_Monocyte|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

ARHGAP26 LRP1 NOTCH2 STAB1

7.73e-05198514a77f3440d7fb6a50066abc7e9ad59e83798ef13d
ToppCell368C-Fibroblasts-Fibroblast-D-|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

FBLN2 FBN1 LRP1 TNFRSF1A

7.89e-051995148766796041965a1ba40ad7abdbc244bf1418c209
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

FBLN2 TRO LRP1 LRP1B

7.89e-05199514333056c2abe9724efeab542c0365fcfe4eff8f18
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC-OPC-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

FBLN2 TRO LRP1 LRP1B

7.89e-0519951419a97e27a4758e794ce7246d295e112b47931a48
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC-OPC|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

FBLN2 TRO LRP1 LRP1B

7.89e-05199514e60ecbb8fa7bcd3e2ce7d78f6efb2cfd1fd77698
ToppCell3'-Broncho-tracheal-Mesenchymal-Fibroblastic|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FBLN2 FBN1 LRP1 COL6A5

7.89e-05199514fb580e9321ddf97c73b2e356cd82523db74a38a2
ToppCell368C-Fibroblasts-Fibroblast-D|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

FBLN2 FBN1 LRP1 TNFRSF1A

7.89e-05199514d39b40d84c72bdde756b805063317ecfad3784f8
ToppCell5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Transitional_Stromal_3_(C3+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FBLN2 FBN1 P2RX2 LRP1

8.04e-05200514cfea2f9d85646c9b722150551ff2e8fc4f6cc98a
ToppCell390C-Fibroblasts-Fibroblast-H|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

FBLN2 FBN1 LRP1 TNFRSF1A

8.04e-05200514019340e8b4b4944a49e14fdec7ce2954cbb8ba2e
ToppCell5'-Adult-SmallIntestine-Mesenchymal-fibroblastic-Transitional_Stromal_3_(C3+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FBLN2 FBN1 P2RX2 LRP1

8.04e-052005146f7f015b5fa1f52374f2c7d9ba339012395eda5f
ToppCellTracheal-10x5prime-Stromal-Fibroblastic-Fibro_peribronchial|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

FBLN2 FBN1 LRP1 COL6A5

8.04e-052005148ab0051544ea32eb8b3f7f8ba7582deaf8bf26c0
ToppCellcontrol-HLA-DR-_S100A+_Monocyte|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

FBN2 LRP1 TNFRSF1A STAB1

8.04e-05200514107a0665fb20247511a430178effd7630a619488
ToppCellLPS_IL1RA-Endothelial-Endothelial-Vein|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

FBLN2 FBN1 TNFRSF1A STAB1

8.04e-05200514b3f93b71589251197cde96b7bc6d065c106f61cd
ToppCell390C-Fibroblasts-Fibroblast-H-|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

FBLN2 FBN1 LRP1 TNFRSF1A

8.04e-05200514b6f21f5cc137eddf6ba90e81cae791b57d88d9d7
ToppCell3'-GW_trimst-1-SmallIntestine-Mesenchymal-immature_mesenchymal_cell|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FBN1 FBN2 LRP1 SIPA1L2

8.04e-052005143dacd0afe69bc16bb33336ea9ea99a9cd47731d9
ToppCell5'-Adult-SmallIntestine-Mesenchymal-fibroblastic|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FBLN2 FBN1 P2RX2 LRP1

8.04e-052005143a164e3971bcd62b148b813171c103adb81f972e
ToppCell3'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Transitional_Stromal_3_(C3+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FBLN2 FBN1 P2RX2 LRP1

8.04e-05200514f6cf98aad53aa8b3fa02cf874d6f7cd75530a213
ToppCell3'-GW_trimst-1-SmallIntestine-Mesenchymal-immature_mesenchymal_cell-Mesoderm_2_(ZEB2+)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FBN1 FBN2 LRP1 SIPA1L2

8.04e-05200514ac8a5d71acd4d401995babd233f0d3738e8ad2a5
ToppCellcontrol-HLA-DR-_S100A+_Monocyte|control / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

FBN2 ARHGAP26 LRP1 STAB1

8.04e-052005149e3e13a68bc1110fa000ec2d80f4c654ddbce17e
ToppCellTracheal-NucSeq-Stromal-Fibroblastic-Fibro_peribronchial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

FBLN2 FBN1 LRP1 COL6A5

8.04e-0520051458b38f9a484ee94191091a0659ed62ebed2d4a14
ToppCell10x5'-Lung-Myeloid_Mac-Intestinal_macrophages|Lung / Manually curated celltypes from each tissue

FBN2 ALPK2 STAB1

5.62e-041415137671d300b1722711fd2d8034b96a3aa7e3ccb560
ToppCell10x5'-bone_marrow-Hematopoietic_progenitors-Progenitor|bone_marrow / Manually curated celltypes from each tissue

FBN1 MCM7 TRIM10

6.22e-04146513035393166f3ad5ab95602a8ae11b7d0ee4b1d691
ToppCell10x5'-bone_marrow-Myeloid_Monocytic-Cycling_mono|bone_marrow / Manually curated celltypes from each tissue

FBN2 LRP1 STAB1

6.47e-04148513de35eeefad0e27a0d127e2e4bedead2bddb75152
ToppCellE18.5-samps-Mesenchymal-Pericyte-pericyte_B|E18.5-samps / Age Group, Lineage, Cell class and subclass

BICRAL SIPA1L2 RUSC2

6.86e-041515138ba15ab24fe2e71df0a2a7511ca451ad2376bd91
ToppCellThalamus-Endothelial-ENDOTHELIAL_TIP-Dcn_1|Thalamus / BrainAtlas - Mouse McCarroll V32

FBLN2 ACSF2 TRIM10

7.12e-04153513e9c6fb5c41adb6595c66c3a917fe455348279e54
ToppCellThalamus-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1|Thalamus / BrainAtlas - Mouse McCarroll V32

FBLN2 ACSF2 TRIM10

7.12e-04153513b8b5ff7d2feea3e3a352fb5530e49f639fe1ff88
ToppCellPBMC-Mild-Myeloid-cDC-cDC-cDC_4|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

FBLN2 ACSF2 PPP1R16A

7.12e-0415351391e9d70a5d3f6fd68c284ed0cc113f03d7d1e10b
ToppCellPBMC-Mild-Myeloid-cDC-cDC-cDC_4|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

FBLN2 ACSF2 PPP1R16A

7.12e-04153513f17f62646633cf95c810dcd5328978058741b276
ToppCellThalamus-Endothelial-ENDOTHELIAL_TIP|Thalamus / BrainAtlas - Mouse McCarroll V32

FBLN2 ACSF2 TRIM10

7.12e-041535132513edfae62a44e51d3556675a096723194c966c
ToppCell367C-Fibroblasts-Fibroblast-D-|367C / Donor, Lineage, Cell class and subclass (all cells)

FBLN2 FBN1 LRP1

7.26e-04154513dd3d34f065820e706515a13619f19a5b12734c8e
ToppCell367C-Fibroblasts-Fibroblast-D|367C / Donor, Lineage, Cell class and subclass (all cells)

FBLN2 FBN1 LRP1

7.26e-041545134bfda1c41efbb86d829b3797d1168bf2587c3c97
ToppCellfacs-Liver-Non-hepatocytes-3m-Endothelial-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBN2 COL6A5 STAB1

7.40e-041555138fdda4e3657ac56188ae88ed3caf145f4d9d1567
ToppCellsevere_COVID-19-cDC|World / disease group, cell group and cell class (v2)

FBLN2 FBN1 ACSF2

7.54e-041565130a7e18ed8e13261c405eb6b9a183e99d8e1aac37
ToppCellE12.5-Hematopoietic|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

IKZF1 TRIM10 STAB1

7.68e-04157513344351c7534440532c6cd4a95782ac90b10d45f3
ToppCell368C-Fibroblasts-Fibroblast-F|368C / Donor, Lineage, Cell class and subclass (all cells)

FBN1 WNT9A ATP8B2

7.68e-0415751374038192f016f95f80e0189035ee8ccc22ceb1b8
ToppCell368C-Fibroblasts-Fibroblast-F-|368C / Donor, Lineage, Cell class and subclass (all cells)

FBN1 WNT9A ATP8B2

7.68e-04157513982e6ea78c7dabdb7c07c4a5fb2425d5e45b5b94
ToppCellCOVID_non-vent-Myeloid-Monocytic-SC_&_Eosinophil|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

FBN1 TRO LALBA

7.82e-041585130d4fe87fc7901dd5f9c004e91708a03cafdb4ad9
ToppCellfacs-Lung-EPCAM-3m-Myeloid-Nonclassical_Monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP1 IKZF1 NOTCH2

7.82e-04158513b0508a600994090c6aafd8d779437190a33ad821
ToppCellfacs-Lung-EPCAM-3m-Myeloid-non-classical_monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP1 IKZF1 NOTCH2

7.82e-04158513a816cc095452308d06f87b77467e2a8c6361fd2a
ToppCellE18.5-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-NK-NK_mature|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

BICRA ARHGAP26 ALPK2

8.11e-041605134a0ae0a83a10dbfc13591f4d2228ba8bcd2c2275
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBN2 COL6A5 LRP1B

8.11e-04160513c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCellNS-critical-d_16-33-Myeloid-Mast_cell|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

FBLN2 TRO STAB1

8.11e-04160513c61869d9dbba250270e59366e15af204e5b4395d
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBN2 COL6A5 LRP1B

8.11e-0416051325c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCell368C-Fibroblasts-Fibroblast-E|368C / Donor, Lineage, Cell class and subclass (all cells)

FBLN2 FBN1 ATP8B2

8.41e-04162513e17632778a57c71d6005d3abca3a0443a92040e7
ToppCell368C-Fibroblasts-Fibroblast-E-|368C / Donor, Lineage, Cell class and subclass (all cells)

FBLN2 FBN1 ATP8B2

8.41e-04162513ac4a80fd72c9311ea2b3e574c6284bbce4f2756c
ToppCellfacs-Liver-Non-hepatocytes-24m-Myeloid-neutrophil|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CYP24A1 SIPA1L2 NOTCH2

8.56e-04163513abec4389cd88252449f110fe95416d67424b403a
ToppCell367C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_6|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

FBLN2 ATP8B2 PPP1R16A

8.56e-0416351363b0badaee3b2d827b1f4524510e3384d8f8fcde
ToppCellLPS-IL1RA+antiTNF-Epithelial_alveolar-Mes-like|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

LRP1 MCM7 LRP1B

8.56e-04163513360cd65decda24853124f33a174f5224d7f3ce23
Drugrapamycin, Streptomyces hygroscepicus; Up 200; 0.1uM; MCF7; HT_HG-U133A

PRPF31 IPO8 CYP24A1 PFDN4 NOTCH2 RUSC2

4.92e-061965165975_UP
DrugDrofenine hydrochloride [548-66-3]; Down 200; 11.4uM; PC3; HT_HG-U133A

IPO8 PHF20L1 KIAA0232 ARHGAP26 PFDN4 TNFRSF1A

5.52e-062005167129_DN
Diseaseconnective tissue disease (implicated_via_orthology)

FBN1 FBN2 FBN3

4.30e-093493DOID:65 (implicated_via_orthology)
Diseaseanemia (phenotype), response to ribavirin

RASGRP3 CYP24A1 PFDN4

3.59e-079493EFO_0004272, GO_1901559
Diseasescoliosis (is_implicated_in)

FBN1 FBN2

1.62e-054492DOID:0060249 (is_implicated_in)
Diseaseaortic aneurysm

FBN1 LRP1

1.21e-0410492EFO_0001666
Diseaselung cancer (is_implicated_in)

MPZL3 CYP24A1 LRP1B

2.57e-0474493DOID:1324 (is_implicated_in)
DiseaseGastro-enteropancreatic neuroendocrine tumor

IKZF1 NOTCH2

2.80e-0415492C2930967
Diseasemultiple sclerosis

ARHGAP26 CYP24A1 IKZF1 PFDN4 TNFRSF1A ALPK2

4.35e-04594496MONDO_0005301
Diseaseinsulin sensitivity measurement, body mass index

CYP24A1 PFDN4

4.54e-0419492EFO_0004340, EFO_0004471
DiseaseLung Injury

ELF3 TNFRSF1A

5.56e-0421492C0273115
DiseaseChronic Lung Injury

ELF3 TNFRSF1A

5.56e-0421492C2350344
DiseaseFEV/FEC ratio

FBN1 KIAA0232 RASGRP3 ARHGAP26 CCSER2 LRP1 MCM7 ARL14EP

8.68e-041228498EFO_0004713
Diseasecolorectal cancer (is_implicated_in)

CYP24A1 IKZF1 LRP1B

1.08e-03121493DOID:9256 (is_implicated_in)
Diseasespontaneous coronary artery dissection

FBN1 LRP1

1.22e-0331492EFO_0010820
Diseasepack-years measurement, systolic blood pressure

SIPA1L2 LRP1B

1.46e-0334492EFO_0006335, EFO_0006526
Diseasehepatocellular carcinoma (is_marker_for)

CHD5 MCM7 IKZF1 LRP1B

1.57e-03301494DOID:684 (is_marker_for)
Diseaselung non-small cell carcinoma (is_implicated_in)

CYP24A1 TNFRSF1A LRP1B

1.61e-03139493DOID:3908 (is_implicated_in)
Diseasecolon cancer (is_implicated_in)

CYP24A1 LRP1B

1.64e-0336492DOID:219 (is_implicated_in)

Protein segments in the cluster

PeptideGeneStartEntry
ECMDGILDESLLETC

BIRC6

4051

Q9NR09
GGCEEEEDDHMEFCR

CHD5

406

Q8TDI0
VCDEPRDREAVCAME

ALPK2

791

Q86TB3
RDREAVCAMECFEAG

ALPK2

796

Q86TB3
LIFSGMDLCDCLDED

ARL14EP

201

Q8N8R7
LECRFFDCMGEEDLI

FAM106A

146

Q4KMX7
DMDGATLCNCALEEL

ELF3

96

P78545
DRMGEEICACIRLKD

ACSF2

546

Q96CM8
PDMRTCVDVDECDLN

FBN3

1231

Q75N90
EREDAILEEGMERFC

DCUN1D3

101

Q8IWE4
EADMELEFLETACAC

ATP8B2

786

P98198
EDCALRMVDRLADGC

NWD1

201

Q149M9
MDCEEDIDDCLANPC

NOTCH2

906

Q04721
LECRFFDCMGEEDLI

FAM106C

146

P0CH98
CDREDDCGDQTDEMA

LRP1B

946

Q9NZR2
RCDADADCMDGSDEE

LRP1

3631

Q07954
ALKDGECEDVDECAM

FBLN2

756

P98095
EDACDDIMLADDDCL

PFDN4

51

Q9NQP4
DFEAECCIVLDGMEL

KIAA0232

546

Q92628
CDKFLDDDITDDIMC

LALBA

96

P00709
DTDQEEEEACMARLC

MPZL3

206

Q6UWV2
CEMNGEECAEDLRML

IKZF1

71

Q13422
RDLCHMANGIEDCDD

ING2

161

Q9H160
VCCIDEFDKMAEADR

MCM7

441

P33993
CLSDADCVAGELDML

P2RX2

136

Q9UBL9
SCDLEDDDLMLDVDL

CCSER2

546

Q9H7U1
MDDDDDSCLLDLIGD

BICRAL

1

Q6AI39
EVLADFMGRIDELCD

CYP24A1

181

Q07973
DRRMCKDEDECEEGK

FBN1

2241

P35555
EVVREICAEKGCEDM

COL6A5

611

A8TX70
EEEGDLCRICQMAAA

MARCHF7

546

Q9H992
DVLMEALEALGCECR

EME2

91

A4GXA9
LDMEERNCTDIDECR

FBN2

1106

P35556
DECAEGLHDCESRGM

FBN2

2296

P35556
MDDEDGRCLLDVICD

BICRA

1

Q9NZM4
DALNEIVRCICEMDE

PHF20L1

676

A8MW92
MCRKVLCGDAGEDAE

IPO8

721

O15397
CRPELEAETMELDEC

RUSC2

191

Q8N2Y8
DEKCTICLSMLEDGE

RNF165

291

Q6ZSG1
LCTCIEMFDDNGELD

RASGRP3

16

Q8IV61
CIGDAETDDEMCIAR

ARHGAP26

71

Q9UNA1
LCDDEQTLDCLETAM

PPP1R16A

176

Q96I34
LECDGAREREDTMEA

SIPA1L2

1161

Q9P2F8
DDMDIDCLTREELGD

TRO

681

Q12816
LQDEEDDSLCRICMD

RNF34

316

Q969K3
DDSLCRICMDAVIDC

RNF34

321

Q969K3
DEEECCICMDGRADL

RNF141

151

Q8WVD5
DADNCEEVVRECAIM

TXNDC2

506

Q86VQ3
EEELERLEEACDMAL

PRPF31

181

Q8WWY3
DECELDMRGGCHTDA

STAB1

906

Q9NY15
EDDEMQLCVVCREAG

TRIM10

111

Q9UDY6
MERCTCDEAPDLENR

WNT9A

146

O14904
REQEVLDCDCDMASV

TBC1D20

261

Q96BZ9
CECLFQAEDRDDMLA

ARHGAP21

1016

Q5T5U3
RDMDLLGCLEDIEEA

TNFRSF1A

426

P19438