Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionolfactory receptor activity

OR5T1 OR2B2 OR6S1 OR6K2 OR2L13 OR8U9 OR8G1 OR10A4 OR4K1 OR10AD1 OR5C1 OR2A25 OR8G5 OR8D4

1.89e-0743111514GO:0004984
GeneOntologyMolecularFunctionodorant binding

OR5T1 OR6K2 OR8U9 OR8G1 OR5C1 OR2A25 OR8G5 OR8D4

7.18e-071271158GO:0005549
GeneOntologyMolecularFunctiongamma-aminobutyric acid:sodium:chloride symporter activity

SLC6A8 SLC6A11 SLC6A13

3.68e-0661153GO:0005332
GeneOntologyMolecularFunctionG protein-coupled receptor activity

OR5T1 OR2B2 OR6S1 OR6K2 PTGFR OR2L13 OR8U9 OR8G1 OR10A4 GPR75 OR4K1 OR10AD1 OR5C1 OR2A25 RXFP1 OR8G5 OR8D4

1.22e-0588411517GO:0004930
GeneOntologyMolecularFunctiongamma-aminobutyric acid transmembrane transporter activity

SLC6A8 SLC6A11 SLC6A13

1.52e-0591153GO:0015185
GeneOntologyMolecularFunctionmonocarboxylate:sodium symporter activity

SLC6A8 SLC6A11 SLC6A13

8.05e-05151153GO:0140161
GeneOntologyMolecularFunctiontaurine:sodium symporter activity

SLC6A11 SLC6A13

9.83e-0531152GO:0005369
GeneOntologyMolecularFunctionsodium:chloride symporter activity

SLC6A8 SLC6A11 SLC6A13

1.19e-04171153GO:0015378
GeneOntologyMolecularFunctionsecondary active monocarboxylate transmembrane transporter activity

SLC6A8 SLC6A11 SLC6A13

1.69e-04191153GO:0015355
GeneOntologyMolecularFunctionmonoatomic anion:sodium symporter activity

SLC6A8 SLC6A11 SLC6A13

1.69e-04191153GO:0015373
GeneOntologyMolecularFunctionmonocarboxylic acid transmembrane transporter activity

SLC6A8 SLC6A11 SLC6A13 ABCB11 SLC16A8

1.73e-04901155GO:0008028
GeneOntologyMolecularFunctioncreatine transmembrane transporter activity

SLC6A8 SLC6A13

1.96e-0441152GO:0005308
GeneOntologyMolecularFunctionchloride:monoatomic cation symporter activity

SLC6A8 SLC6A11 SLC6A13

3.03e-04231153GO:0015377
GeneOntologyMolecularFunctionamino acid:sodium symporter activity

SLC6A8 SLC6A11 SLC6A13

3.03e-04231153GO:0005283
GeneOntologyMolecularFunctiontaurine transmembrane transporter activity

SLC6A11 SLC6A13

3.25e-0451152GO:0005368
GeneOntologyMolecularFunctionmonoatomic anion:monoatomic cation symporter activity

SLC6A8 SLC6A11 SLC6A13

4.39e-04261153GO:0015296
GeneOntologyMolecularFunctionamino acid:monoatomic cation symporter activity

SLC6A8 SLC6A11 SLC6A13

6.10e-04291153GO:0005416
GeneOntologyMolecularFunctioncholine transmembrane transporter activity

SLC44A2 SLC6A8

9.00e-0481152GO:0015220
GeneOntologyMolecularFunctionorganic acid:sodium symporter activity

SLC6A8 SLC6A11 SLC6A13

1.06e-03351153GO:0005343
GeneOntologyMolecularFunctionsolute:sodium symporter activity

SLC6A8 SLC6A11 SLC6A13 SLC29A1

1.23e-03811154GO:0015370
GeneOntologyMolecularFunctionsecondary active transmembrane transporter activity

SLC44A2 SLCO3A1 SLC6A8 SLC6A11 SLC6A13 SLC29A1 SLC16A8

1.64e-032961157GO:0015291
GeneOntologyMolecularFunctionsymporter activity

SLC6A8 SLC6A11 SLC6A13 SLC29A1 SLC16A8

1.77e-031501155GO:0015293
GeneOntologyMolecularFunctiontransmembrane signaling receptor activity

OR5T1 OR2B2 OR6S1 OR6K2 PTGFR OR2L13 OR8U9 OR8G1 OR10A4 GPR75 OR4K1 OR10AD1 OR5C1 OR2A25 RXFP1 OR8G5 OR8D4

1.89e-03135311517GO:0004888
GeneOntologyMolecularFunctionhistone H3K9 demethylase activity

KDM3B JMJD1C

2.86e-03141152GO:0032454
GeneOntologyBiologicalProcessdetection of stimulus

OR5T1 OR2B2 OR6S1 OR6K2 TLR9 PKD1L2 OR2L13 OR8U9 OR8G1 OR10A4 OR4K1 OR10AD1 OR5C1 CAMKMT OR2A25 RP1 OR8G5 OR8D4

4.94e-0872211018GO:0051606
GeneOntologyBiologicalProcessdetection of chemical stimulus involved in sensory perception of smell

OR5T1 OR2B2 OR6S1 OR6K2 OR2L13 OR8U9 OR8G1 OR10A4 OR4K1 OR10AD1 OR5C1 OR2A25 OR8G5 OR8D4

7.48e-0843211014GO:0050911
GeneOntologyBiologicalProcessdetection of chemical stimulus

OR5T1 OR2B2 OR6S1 OR6K2 TLR9 OR2L13 OR8U9 OR8G1 OR10A4 OR4K1 OR10AD1 OR5C1 OR2A25 OR8G5 OR8D4

1.24e-0752411015GO:0009593
GeneOntologyBiologicalProcesssensory perception of smell

OR5T1 OR2B2 OR6S1 OR6K2 OR2L13 OR8U9 OR8G1 OR10A4 OR4K1 OR10AD1 OR5C1 OR2A25 OR8G5 OR8D4

1.84e-0746511014GO:0007608
GeneOntologyBiologicalProcessdetection of chemical stimulus involved in sensory perception

OR5T1 OR2B2 OR6S1 OR6K2 OR2L13 OR8U9 OR8G1 OR10A4 OR4K1 OR10AD1 OR5C1 OR2A25 OR8G5 OR8D4

3.06e-0748511014GO:0050907
GeneOntologyBiologicalProcesssensory perception of chemical stimulus

OR5T1 OR2B2 OR6S1 OR6K2 OR2L13 OR8U9 OR8G1 OR10A4 OR4K1 OR10AD1 OR5C1 OR2A25 OR8G5 OR8D4

1.28e-0654711014GO:0007606
GeneOntologyBiologicalProcessdetection of stimulus involved in sensory perception

OR5T1 OR2B2 OR6S1 OR6K2 OR2L13 OR8U9 OR8G1 OR10A4 OR4K1 OR10AD1 OR5C1 OR2A25 OR8G5 OR8D4

2.65e-0658211014GO:0050906
GeneOntologyBiologicalProcessG protein-coupled receptor signaling pathway

PRKD2 OR5T1 OR2B2 OR6S1 OR6K2 PTGFR OR2L13 ADCY6 OR8U9 OR8G1 OR10A4 GPR75 OR4K1 OR10AD1 OR5C1 CAMKMT OR2A25 RXFP1 OR8G5 OR8D4

4.37e-05139511020GO:0007186
GeneOntologyBiologicalProcesssensory perception

OR5T1 WDR36 OR2B2 OR6S1 OR6K2 OR2L13 OR8U9 OR8G1 OR10A4 OR4K1 OR10AD1 OR5C1 OR2A25 RP1 OR8G5 OR8D4 CLRN1

5.18e-05107211017GO:0007600
GeneOntologyBiologicalProcessmonocarboxylic acid transport

ACACB SLCO3A1 SLC6A8 SLC6A11 SLC6A13 ABCB11 SLC16A8

1.47e-042131107GO:0015718
GeneOntologyBiologicalProcesspositive regulation of NF-kappaB transcription factor activity

PRKD2 SLCO3A1 TLR9 CHUK PRKCI EIF2AK2

1.60e-041511106GO:0051092
GeneOntologyBiologicalProcessgamma-aminobutyric acid reuptake

SLC6A11 SLC6A13

1.68e-0441102GO:0051936
GeneOntologyBiologicalProcesscreatine transmembrane transport

SLC6A8 SLC6A13

1.68e-0441102GO:0015881
GeneOntologyBiologicalProcessneurotransmitter uptake

GPM6B SLC6A11 SLC6A13 SLC29A1

1.70e-04521104GO:0001504
GeneOntologyBiologicalProcessorganic acid transmembrane transport

ACACB SLC6A8 SLC6A11 SLC6A13 ARL6IP1 SLC16A8

2.75e-041671106GO:1903825
GeneOntologyBiologicalProcessresponse to camptothecin

RECQL5 SPIDR

2.79e-0451102GO:1901563
GeneOntologyBiologicalProcesscellular response to camptothecin

RECQL5 SPIDR

2.79e-0451102GO:0072757
GeneOntologyBiologicalProcesspositive regulation of ossification

GPM6B ZBTB16 NELL1 FBN2

4.28e-04661104GO:0045778
GeneOntologyBiologicalProcessgamma-aminobutyric acid transport

SLC6A8 SLC6A11 SLC6A13

4.39e-04281103GO:0015812
DomainOlfact_rcpt

OR5T1 OR2B2 OR6S1 OR6K2 OR2L13 OR8U9 OR8G1 OR10A4 OR4K1 OR10AD1 OR5C1 OR2A25 OR8G5 OR8D4

1.10e-0739311314IPR000725
DomainGPCR_Rhodpsn_7TM

OR5T1 OR2B2 OR6S1 OR6K2 PTGFR OR2L13 OR8U9 OR8G1 OR10A4 GPR75 OR4K1 OR10AD1 OR5C1 OR2A25 RXFP1 OR8G5 OR8D4

5.62e-0767011317IPR017452
Domain7tm_1

OR5T1 OR2B2 OR6S1 OR6K2 PTGFR OR2L13 OR8U9 OR8G1 OR10A4 GPR75 OR4K1 OR10AD1 OR5C1 OR2A25 RXFP1 OR8G5 OR8D4

6.49e-0767711317PF00001
DomainG_PROTEIN_RECEP_F1_1

OR5T1 OR2B2 OR6S1 OR6K2 PTGFR OR2L13 OR8U9 OR8G1 OR10A4 GPR75 OR4K1 OR10AD1 OR5C1 OR2A25 RXFP1 OR8G5 OR8D4

7.63e-0768511317PS00237
DomainG_PROTEIN_RECEP_F1_2

OR5T1 OR2B2 OR6S1 OR6K2 PTGFR OR2L13 OR8U9 OR8G1 OR10A4 GPR75 OR4K1 OR10AD1 OR5C1 OR2A25 RXFP1 OR8G5 OR8D4

8.61e-0769111317PS50262
DomainGPCR_Rhodpsn

OR5T1 OR2B2 OR6S1 OR6K2 PTGFR OR2L13 OR8U9 OR8G1 OR10A4 GPR75 OR4K1 OR10AD1 OR5C1 OR2A25 RXFP1 OR8G5 OR8D4

8.78e-0769211317IPR000276
DomainNA_NEUROTRAN_SYMP_2

SLC6A8 SLC6A11 SLC6A13

1.65e-04181133PS00754
DomainSNF

SLC6A8 SLC6A11 SLC6A13

1.95e-04191133PF00209
DomainNA_NEUROTRAN_SYMP_1

SLC6A8 SLC6A11 SLC6A13

1.95e-04191133PS00610
DomainNA_NEUROTRAN_SYMP_3

SLC6A8 SLC6A11 SLC6A13

1.95e-04191133PS50267
DomainNa/ntran_symport

SLC6A8 SLC6A11 SLC6A13

1.95e-04191133IPR000175
DomainLON

LONRF1 LONRF2

5.36e-0461132SM00464
DomainRNase_PH_C

EXOSC5 EXOSC4

5.36e-0461132PF03725
Domain-

EXOSC5 EXOSC4

5.36e-04611323.30.230.70
DomainLON_N

LONRF1 LONRF2

5.36e-0461132PS51787
DomainLON_substr-bd_dom

LONRF1 LONRF2

5.36e-0461132IPR003111
DomainLON_substr_bdg

LONRF1 LONRF2

5.36e-0461132PF02190
DomainPNPase/RNase_PH_dom

EXOSC5 EXOSC4

5.36e-0461132IPR027408
DomainExoRNase_PH_dom2

EXOSC5 EXOSC4

7.47e-0471132IPR015847
DomainRNase_PH

EXOSC5 EXOSC4

7.47e-0471132PF01138
DomainARM-type_fold

CLTCL1 MROH2A DOCK5 PPP2R5B PSME4 UPF2 LTN1 HEATR3

1.06e-033391138IPR016024
PathwayREACTOME_OLFACTORY_SIGNALING_PATHWAY

OR5T1 OR2B2 OR6S1 OR6K2 OR2L13 OR8U9 OR8G1 OR10A4 OR4K1 OR10AD1 OR5C1 OR2A25 OR8G5 OR8D4

3.68e-074179014M4072
PathwayKEGG_OLFACTORY_TRANSDUCTION

OR5T1 OR2B2 OR6S1 OR6K2 OR2L13 OR8G1 OR10A4 OR4K1 OR10AD1 OR5C1 OR2A25 OR8G5 OR8D4

1.06e-063899013M14091
PathwayREACTOME_SENSORY_PERCEPTION

OR5T1 OR2B2 OR6S1 OR6K2 OR2L13 OR8U9 OR8G1 OR10A4 KCNJ2 OR4K1 OR10AD1 OR5C1 CAMKMT OR2A25 OR8G5 OR8D4

2.33e-066369016M41834
PathwayREACTOME_TRANSPORT_OF_BILE_SALTS_AND_ORGANIC_ACIDS_METAL_IONS_AND_AMINE_COMPOUNDS

RHBG SLC44A2 SLC6A11 SLC6A13 SLC16A8

1.23e-0476905MM15072
PathwayREACTOME_TRANSPORT_OF_BILE_SALTS_AND_ORGANIC_ACIDS_METAL_IONS_AND_AMINE_COMPOUNDS

RHBG SLC44A2 SLC6A11 SLC6A13 SLC16A8

1.97e-0484905M27334
Pubmed

Different evolutionary processes shaped the mouse and human olfactory receptor gene families.

OR5T1 OR2B2 OR6S1 OR6K2 OR2L13 OR8G1 OR10A4 OR4K1 OR10AD1 OR5C1 OR2A25 OR8G5 OR8D4

1.32e-103401161311875048
Pubmed

A unified nomenclature for vertebrate olfactory receptors.

OR5T1 OR2B2 OR6S1 OR6K2 OR2L13 OR8G1 OR10A4 OR4K1 OR10AD1 OR5C1 OR2A25 OR8G5 OR8D4

1.47e-103431161332295537
Pubmed

Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.

OR5T1 OR2B2 OR6S1 OR6K2 OR2L13 OR8G1 OR10A4 OR4K1 OR10AD1 OR5C1 OR2A25 OR8G5 OR8D4

1.64e-103461161314611657
Pubmed

The olfactory receptor gene superfamily of the mouse.

OR5T1 OR2B2 OR6K2 OR2L13 OR8G1 OR10A4 OR4K1 OR10AD1 OR5C1 OR2A25 OR8G5 OR8D4

1.74e-093401161211802173
Pubmed

Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.

GNL3L KDM3B WLS JMJD1C ADCY6 DOCK5 PSME4 UPF2 ASB3 NFXL1 HELZ PRKCI HEATR3

2.85e-076501161338777146
Pubmed

Genome-wide association analysis identifies 11 risk variants associated with the asthma with hay fever phenotype.

IKZF3 WDR36 XKR6 VAV3

8.20e-0722116424388013
Pubmed

The human olfactory receptor gene family.

OR5T1 OR2B2 OR6S1 OR6K2 OR8G1 OR10A4 OR4K1 OR10AD1 OR5C1 OR8G5 OR8D4

2.11e-065411161114983052
Pubmed

Impaired adhesion of neutrophils expressing Slc44a2/HNA-3b to VWF protects against NETosis under venous shear rates.

VWF SLC44A2

1.10e-052116233556175
Pubmed

Molecular heterogeneity of the gamma-aminobutyric acid (GABA) transport system. Cloning of two novel high affinity GABA transporters from rat brain.

SLC6A11 SLC6A13

1.10e-05211621400419
Pubmed

Determinants of platelet activation in hypertensives with microalbuminuria.

SELP PTGFR

1.10e-052116219280705
Pubmed

Substrate-Na+ complex formation: coupling mechanism for gamma-aminobutyrate symporters.

SLC6A11 SLC6A13

1.10e-052116219450549
Pubmed

von Willebrand factor promotes leukocyte extravasation.

SELP VWF

1.10e-052116220716766
Pubmed

NF-kappaB activation by double-stranded-RNA-activated protein kinase (PKR) is mediated through NF-kappaB-inducing kinase and IkappaB kinase.

CHUK EIF2AK2

1.10e-052116210648614
Pubmed

Innate PLZF+CD4+ αβ T cells develop and expand in the absence of Itk.

ZBTB16 ITK

1.10e-052116224928994
Pubmed

Increased von Willebrand factor, P-selectin and fibrin content in occlusive thrombus resistant to lytic therapy.

SELP VWF

1.10e-052116226962963
Pubmed

Differential role of von Willebrand factor and P-selectin on microvascular thrombosis in endotoxemia.

SELP VWF

1.10e-052116218802014
Pubmed

Microvesicles from stored red blood cells induce P-selectin and von Willebrand factor release from endothelial cells via a protein kinase C-dependent mechanism.

SELP VWF

1.10e-052116238355315
Pubmed

P-selectin anchors newly released ultralarge von Willebrand factor multimers to the endothelial cell surface.

SELP VWF

1.10e-052116214630802
Pubmed

Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1.

SETDB1 PSME4 ARL6IP1 HELZ

1.19e-054211647584044
Pubmed

Neurotransmitter transporter family including SLC6A6 and SLC6A13 contributes to the 5-aminolevulinic acid (ALA)-induced accumulation of protoporphyrin IX and photodamage, through uptake of ALA by cancerous cells.

SLC6A8 SLC6A13

3.30e-053116224842606
Pubmed

Effects of toll-like receptor-4 gene polymorphisms on soluble P-selectin and von Willebrand factor levels in hypercholesterolemic patients.

SELP VWF

3.30e-053116217849054
Pubmed

The catalytic activity of dsRNA-dependent protein kinase, PKR, is required for NF-kappaB activation.

CHUK EIF2AK2

3.30e-053116211313968
Pubmed

Expression of P-selectin, von Willebrand and endothelin-1 after carotid artery stenting.

SELP VWF

3.30e-053116221638248
Pubmed

Expression and significance of vWF, GMP-140 and ADAMTS13 in patients with aneurysmal subarachnoid hemorrhage.

SELP VWF

3.30e-053116229077161
Pubmed

P-selectin can promote thrombus propagation independently of both von Willebrand factor and thrombospondin-1 in mice.

SELP VWF

3.30e-053116227943541
Pubmed

Platelet adhesion receptors do not modulate infarct volume after a photochemically induced stroke in mice.

SELP VWF

3.30e-053116217996853
Pubmed

Astrocytic γ-aminobutyric acid (GABA) transporters mediate guanidinoacetate transport in rat brain.

SLC6A11 SLC6A13

3.30e-053116229175673
Pubmed

Developmental expression of the neurotransmitter transporter GAT3.

SLC6A11 SLC6A13

3.30e-053116210348670
Pubmed

Effects of radiofrequency catheter ablation of atrial fibrillation on soluble P-selectin, von Willebrand factor and IL-6 in the peripheral and cardiac circulation.

SELP VWF

3.30e-053116225390649
Pubmed

CD36 is expressed in a defined subpopulation of neurons in the olfactory epithelium.

OR10A4 OR10AD1

3.30e-053116227145700
Pubmed

The expression of von Willebrand factor, soluble thrombomodulin, and soluble p-selectin during orthotopic liver transplantation.

SELP VWF

3.30e-053116217275499
Pubmed

Soluble CD40 ligand, soluble P-selectin and von Willebrand factor levels in subjects with prediabetes: the impact of metabolic syndrome.

SELP VWF

3.30e-053116222100896
Pubmed

Endothelial cell markers in patients with pseudoexfoliation syndrome.

SELP VWF

3.30e-053116222593709
Pubmed

Endothelial von Willebrand factor recruits platelets to atherosclerosis-prone sites in response to hypercholesterolemia.

SELP VWF

3.30e-053116212036879
Pubmed

Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development.

WDR36 MROH2A EXOSC5 DOCK5 SPTBN5 NELL1 RBM6 EIF2AK2 EXOSC4

4.49e-05496116931343991
Pubmed

The repertoire of solute carriers of family 6: identification of new human and rodent genes.

SLC6A8 SLC6A11 SLC6A13

4.60e-0521116316125675
Pubmed

A link between nuclear RNA surveillance, the human exosome and RNA polymerase II transcriptional termination.

EXOSC5 EXOSC4

6.59e-054116220699273
Pubmed

Protein complex interactor analysis and differential activity of KDM3 subfamily members towards H3K9 methylation.

KDM3B JMJD1C

6.59e-054116223593242
Pubmed

Platelets adhere to and translocate on von Willebrand factor presented by endothelium in stimulated veins.

SELP VWF

6.59e-054116211071623
Pubmed

Activated platelets induce Weibel-Palade-body secretion and leukocyte rolling in vivo: role of P-selectin.

SELP VWF

6.59e-054116215956287
Pubmed

PKR stimulates NF-kappaB irrespective of its kinase function by interacting with the IkappaB kinase complex.

CHUK EIF2AK2

6.59e-054116210848580
Pubmed

Hypotaurine Is a Substrate of GABA Transporter Family Members GAT2/Slc6a13 and TAUT/Slc6a6.

SLC6A11 SLC6A13

6.59e-054116230270321
Pubmed

The interaction between IKKα and LC3 promotes type I interferon production through the TLR9-containing LAPosome.

TLR9 CHUK

6.59e-054116229717061
Pubmed

Atypical protein kinase C phosphorylates IKKalphabeta in transformed non-malignant and malignant prostate cell survival.

CHUK PRKCI

6.59e-054116218571841
Pubmed

Factors associated with early platelet activation in obese children.

SELP VWF

6.59e-054116224415745
Pubmed

Jarid2 is induced by TCR signalling and controls iNKT cell maturation.

ZBTB16 ITK

6.59e-054116225105474
Pubmed

Molecular characterization of four pharmacologically distinct gamma-aminobutyric acid transporters in mouse brain [corrected].

SLC6A11 SLC6A13

6.59e-05411628420981
Pubmed

Embryonic and postnatal expression of four gamma-aminobutyric acid transporter mRNAs in the mouse brain and leptomeninges.

SLC6A11 SLC6A13

1.10e-04511628956109
Pubmed

An anti-interferon activity shared by paramyxovirus C proteins: inhibition of Toll-like receptor 7/9-dependent alpha interferon induction.

TLR9 CHUK

1.10e-045116224269682
Pubmed

Osteopetrosis-Associated Transmembrane Protein 1 Recruits RNA Exosome To Restrict Hepatitis B Virus Replication.

EXOSC5 EXOSC4

1.10e-045116232188736
Pubmed

Histone methyltransferase Ezh2 coordinates mammalian axon regeneration via regulation of key regenerative pathways.

LINGO3 SLC6A13

1.10e-045116238015636
Pubmed

Mapping of atypical protein kinase C within the nerve growth factor signaling cascade: relationship to differentiation and survival of PC12 cells.

CHUK PRKCI

1.10e-045116210848576
Pubmed

A Cdc42/RhoA regulatory circuit downstream of glycoprotein Ib guides transendothelial platelet biogenesis.

VWF PRKCI

1.10e-045116228643773
Pubmed

Inflammation induces hemorrhage in thrombocytopenia.

SELP VWF

1.10e-045116218256319
Pubmed

Deletion of the γ-aminobutyric acid transporter 2 (GAT2 and SLC6A13) gene in mice leads to changes in liver and brain taurine contents.

SLC6A11 SLC6A13

1.10e-045116222896705
Pubmed

JMJD1C Exhibits Multiple Functions in Epigenetic Regulation during Spermatogenesis.

ZBTB16 JMJD1C PSME4

1.24e-0429116327649575
Pubmed

A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene.

GNL3L WDR36 KDM3B SPTBN5 OR4K1 ZMAT1 EXOSC4

1.28e-04331116719490893
Pubmed

Whole genome association study identifies polymorphisms associated with QT prolongation during iloperidone treatment of schizophrenia.

SLCO3A1 NRG3

1.64e-046116218521091
Pubmed

Fibrinogen is required for maintenance of platelet intracellular and cell-surface P-selectin expression.

SELP VWF

1.64e-046116219332769
Pubmed

Development of promyelocytic leukemia zinc finger-expressing innate CD4 T cells requires stronger T-cell receptor signals than conventional CD4 T cells.

ZBTB16 ITK

1.64e-046116222988097
Pubmed

CircRNA-CREIT inhibits stress granule assembly and overcomes doxorubicin resistance in TNBC by destabilizing PKR.

SPIDR EIF2AK2

1.64e-046116236038948
Pubmed

IkappaB kinase-alpha is critical for interferon-alpha production induced by Toll-like receptors 7 and 9.

TLR9 CHUK

1.64e-046116216612387
Pubmed

The yeast exosome and human PM-Scl are related complexes of 3' --> 5' exonucleases.

EXOSC5 EXOSC4

1.64e-046116210465791
Pubmed

Structure of an Rrp6-RNA exosome complex bound to poly(A) RNA.

EXOSC5 EXOSC4

1.64e-046116225043052
Pubmed

H3K9 Demethylases JMJD1A and JMJD1B Control Prospermatogonia to Spermatogonia Transition in Mouse Germline.

ZBTB16 KDM3B

1.64e-046116232679061
Pubmed

[IMAGE: molecular integration of the analysis of the human genome and its expression].

ZNF462 NELL1 EIF2AK2

2.19e-043511637757816
Pubmed

Bruton's tyrosine kinase and protein kinase C µ are required for TLR7/9-induced IKKα and IRF-1 activation and interferon-β production in conventional dendritic cells.

TLR9 CHUK

2.29e-047116225170774
Pubmed

DDX60, a DEXD/H box helicase, is a novel antiviral factor promoting RIG-I-like receptor-mediated signaling.

EXOSC5 EXOSC4

2.29e-047116221791617
Pubmed

Direct phosphorylation of IkappaB by IKKalpha and IKKbeta: discrimination between free and NF-kappaB-bound substrate.

CHUK EIF2AK2

2.29e-04711629721103
Pubmed

Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition.

PRKD2 ITK SETDB1 NPRL2 ASB3 PRKCI EIF2AK2

2.60e-04372116722939624
Pubmed

Heat stable antigen (mouse CD24) supports myeloid cell binding to endothelial and platelet P-selectin.

SELP VWF

3.05e-04811628562500
Pubmed

Autoantibodies directed to novel components of the PM/Scl complex, the human exosome.

EXOSC5 EXOSC4

3.05e-048116211879549
Pubmed

Platelet GPIbα is a mediator and potential interventional target for NASH and subsequent liver cancer.

SELP VWF

3.05e-048116230936549
Pubmed

Critical role of IkappaB Kinase alpha in TLR7/9-induced type I IFN production by conventional dendritic cells.

TLR9 CHUK

3.91e-049116220200270
Pubmed

Microfibril-associated glycoprotein-2 interacts with fibrillin-1 and fibrillin-2 suggesting a role for MAGP-2 in elastic fiber assembly.

VWF FBN2

3.91e-049116212122015
Pubmed

Structure of a Cytoplasmic 11-Subunit RNA Exosome Complex.

EXOSC5 EXOSC4

3.91e-049116227345150
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

DYNLT2B GNL3L ZBTB16 JMJD1C ZNF462 DOCK5 TTLL11 RBM6 CAMKMT PRKCI SPIDR NRG3 ABLIM2 ZMAT1

4.48e-0414891161428611215
Pubmed

Activation of NF-kappa B by the dsRNA-dependent protein kinase, PKR involves the I kappa B kinase complex.

CHUK EIF2AK2

4.88e-0410116210723127
Pubmed

Low expression of EXOSC2 protects against clinical COVID-19 and impedes SARS-CoV-2 replication.

EXOSC5 EXOSC4

4.88e-0410116236241425
Pubmed

The contribution of genetic factors to thrombotic and bleeding outcomes in coronary patients randomised to IIb/IIIa antagonists.

SELP VWF

4.88e-0410116212082590
Pubmed

Mpp6 Incorporation in the Nuclear Exosome Contributes to RNA Channeling through the Mtr4 Helicase.

EXOSC5 EXOSC4

4.88e-0410116228877463
Pubmed

Characterization of a cluster comprising approximately 100 odorant receptor genes in mouse.

OR8G1 OR8G5

4.88e-0410116211130974
Pubmed

Rapid-throughput skeletal phenotyping of 100 knockout mice identifies 9 new genes that determine bone strength.

SETDB1 MIGA2

4.88e-0410116222876197
Pubmed

Discovery of aminothiazole inhibitors of cyclin-dependent kinase 2: synthesis, X-ray crystallographic analysis, and biological activities.

ITK CHUK

5.95e-0411116212190313
Pubmed

The association of the human PM/Scl-75 autoantigen with the exosome is dependent on a newly identified N terminus.

EXOSC5 EXOSC4

5.95e-0411116212788944
Pubmed

Reconstitution, activities, and structure of the eukaryotic RNA exosome.

EXOSC5 EXOSC4

5.95e-0411116217174896
Pubmed

Nonsense-mediated mRNA decay in mammalian cells involves decapping, deadenylating, and exonucleolytic activities.

UPF2 EXOSC4

7.12e-0412116214527413
Pubmed

Pathogen recognition in the innate immune response.

TLR9 CHUK

7.12e-0412116219382893
Pubmed

Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring.

EXOSC5 EXOSC4

7.12e-0412116212419256
Pubmed

Three novel components of the human exosome.

EXOSC5 EXOSC4

7.12e-0412116211110791
Pubmed

Protein-protein interactions of hCsl4p with other human exosome subunits.

EXOSC5 EXOSC4

8.40e-0413116211812149
Pubmed

Dis3-like 1: a novel exoribonuclease associated with the human exosome.

EXOSC5 EXOSC4

8.40e-0413116220531389
Pubmed

The RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substrates.

EXOSC5 EXOSC4

8.40e-0413116221255825
Pubmed

Does parental expressed emotion moderate genetic effects in ADHD? An exploration using a genome wide association scan.

ZBTB16 NRG3

8.40e-0413116218846501
Pubmed

Functional proteomics mapping of a human signaling pathway.

PRKD2 ZBTB16 VWF KDM3B DNAJC7 SETDB1 FBN2 ZBTB3

8.46e-04591116815231748
Pubmed

Insertion of a neomycin selection cassette in the Amigo1 locus alters gene expression in the olfactory epithelium leading to region-specific defects in olfactory receptor neuron development.

OR10A4 OR10AD1

9.78e-0414116238590146
Pubmed

Molecular dissection of plasmacytoid dendritic cell activation in vivo during a viral infection.

TLR9 CHUK

9.78e-0414116230131424
Pubmed

A genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple Loci implicated in sex steroid hormone regulation.

JMJD1C PRMT6

9.78e-0414116222829776
Pubmed

Multiplexed molecular interactions of nuclear receptors using fluorescent microspheres.

JMJD1C ZNHIT3

9.78e-0414116211500849
Pubmed

Activation of IkappaB kinase beta by protein kinase C isoforms.

CHUK PRKCI

9.78e-0414116210022904
Cytoband2p16.2

PSME4 ASB3

2.25e-04911622p16.2
Cytoband3p21.3

TLR9 NPRL2 RBM6

4.61e-045911633p21.3
GeneFamilyOlfactory receptors, family 8

OR8U9 OR8G1 OR8G5 OR8D4

5.86e-0549784155
GeneFamilySolute carriers

RHBG SLC44A2 SLCO3A1 SLC6A8 SLC6A11 SLC6A13 SLC29A1 SLC16A8

2.99e-04395788752
GeneFamilyExosome complex

EXOSC5 EXOSC4

1.18e-0312782817
ToppCell3'_v3-bone_marrow-Hematopoietic_Erythro-Mega|bone_marrow / Manually curated celltypes from each tissue

SELP VWF GPT COL6A5 ADCY6 GCAT SLC29A1

5.54e-0718611579ff3c30b1728707bb8f9422941333fe3b2c430f4
ToppCellPND07-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-ILC-ILC_G2M|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MROH2A ITK ZNF462 SLC6A13 GCAT WDR90

4.98e-061681156a7eb28e15b591997f1aee09501cb20ae18beca08
ToppCellwk_20-22-Endothelial-Blood_vessel_endothelial-OMD+_endo|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

SELP SFRP4 VWF TSPAN2 FBN2 NRG3

6.50e-06176115652af8f717dbd3b59eeb868b8b7b256a8f3e57d7a
ToppCellwk_15-18-Endothelial-Blood_vessel_endothelial-OMD+_endo|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

SELP SFRP4 VWF TSPAN2 FBN2 NRG3

7.16e-0617911568c9ed247e1c4d655b81ce2f24a9936a7cade718a
ToppCellFetal_29-31_weeks-Endothelial-endothelial_cell_of_vein-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

SELP ZBTB16 VWF DYSF RXFP1 NRG3

7.63e-0618111562c660fcf0404c155955b67ab2958d6e6b0e30024
ToppCellControl-Endothelial_cells|Control / group, cell type (main and fine annotations)

SELP ZBTB16 VWF DYSF RXFP1 NRG3

9.48e-0618811563953b08abfea93468fc8d177bdb16ca7c6ffa1ab
ToppCellrenal_medulla_nuclei|World / Celltypes from Cells and Nuclei per compartment and clinical group

ACACB SLCO3A1 NELL1 CAMKMT VAV3 RP1

9.77e-061891156830d9cd0dd706bce22eb2416f07b2c31c870a05a
ToppCellPCW_13-14-Endothelial-Endothelial_immature-endo_immature4_(5)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

VWF LONRF1 DYSF KCNJ2 RXFP1 NRG3

1.10e-05193115601c71aa48875b5ad6c50cc810a72862e72f26ad0
ToppCell367C-Myeloid-Dendritic-cDC1|Dendritic / Donor, Lineage, Cell class and subclass (all cells)

DYSF JMJD1C TSPAN2 UPF2 KCNJ2 VAV3

1.17e-051951156fca958f73de450ef813444d3dc590353f1c55326
Diseaseasthma, seasonal allergic rhinitis

IKZF3 WDR36 XKR6 VAV3

5.64e-06321084EFO_0003956, MONDO_0004979
Diseaseobsolete_red blood cell distribution width

EXOSC5 XKR6 ZNHIT3 PRMT6 DOCK5 NPRL2 FBN2 CNIH4 ASB3 RBM6 ABCB11 RP1 EIF2AK2 SLC29A1 HEATR3

1.17e-04134710815EFO_0005192
Diseasecentral nervous system cancer, glioma

ZBTB16 SLC16A8 HEATR3

1.63e-04291083EFO_0000326, EFO_0005543
Diseaseresponse to iloperidone

SLCO3A1 NRG3

1.97e-0461082GO_0036287
Diseaseserum alanine aminotransferase measurement

DPAGT1 GPT SPATA18 XKR6 ITK CHUK PRMT6 LTN1 RBM6 ABCB11 RP1

3.49e-0486910811EFO_0004735
Diseaseglucagon-like peptide-1 measurement, glucose tolerance test

DPAGT1 GPT

3.66e-0481082EFO_0004307, EFO_0008465
DiseasePancreatic Ductal Adenocarcinoma

ACACB ABLIM2

7.14e-04111082C1335302
DiseaseC-C motif chemokine 28 measurement

ZBTB16 JMJD1C

8.55e-04121082EFO_0020199
DiseaseCandidemia

SLCO3A1 SPTBN5

8.55e-04121082EFO_1001282
Diseasecentral nervous system cancer, glioblastoma multiforme

SLC16A8 HEATR3

1.17e-03141082EFO_0000326, EFO_0000519
Diseasebehavioural inhibitory control measurement

MROH2A TTLL11

1.54e-03161082EFO_0008467
Diseaselifestyle measurement

ZBTB16 XKR6 PRMT6 TTLL11 HELZ

1.76e-032351085EFO_0010724
Diseaseaspartate aminotransferase to alanine aminotransferase ratio

DPAGT1 GPT ITK ABCB11 RP1

1.89e-032391085EFO_0010934
Diseasevenous thromboembolism, fibrinogen measurement

VWF SLC44A2 JMJD1C

1.93e-03671083EFO_0004286, EFO_0004623
Diseasetaurocholate measurement

DOCK5 NELL1

2.42e-03201082EFO_0010538
DiseaseCraniosynostosis

ZNF462 NELL1

2.42e-03201082C0010278
Diseasevenous thromboembolism, plasminogen activator inhibitor 1 measurement

VWF SLC44A2

2.66e-03211082EFO_0004286, EFO_0004792
Diseaselymphocyte percentage of leukocytes

DPAGT1 IKZF3 XKR6 JMJD1C DOCK5 ZBTB25 ASB3 HELZ

3.12e-036651088EFO_0007993
Diseasevenous thromboembolism, tissue plasminogen activator measurement

VWF SLC44A2

3.19e-03231082EFO_0004286, EFO_0004791
Diseasealcohol drinking

LONRF1 TTLL11 LONRF2

3.31e-03811083EFO_0004329

Protein segments in the cluster

PeptideGeneStartEntry
GLQDFIICIEMFLAA

TMEM184C

291

Q9NVA4
LAQCGVMFDFLDCVA

PPP2R5B

81

Q15173
DMFFCLRLLEETGIC

GPT

436

P24298
CAAALFVGLMVVCNR

ADCY6

186

O43306
NGVCLLFVAMGCVSL

ABCB11

796

O95342
VLSGVSCFVMFLCLA

ARL6IP1

66

Q15041
ALCVRCGQMFAEGEE

ABLIM2

236

Q6H8Q1
RFGADVTCGEMAVCT

DUS3L

326

Q96G46
CFEIQLLSFMGLFIC

GKN3P

161

P0CG01
VDMFGCCLPVCAVNF

ALG1L

76

Q6GMV1
TGICEVCLLTVMAFD

OR6K2

106

Q8NGY2
ALAGVFMAVATNCCL

SLC16A8

421

O95907
GFRCVTDECPIAVFM

KCNJ2

146

P63252
GCCFLAFCIRSLMDV

LITAFD

41

A0A1B0GVX0
DKRFEGVEDCMICFS

LTN1

1706

O94822
GVEDCMICFSVIHGF

LTN1

1711

O94822
VCGALNVADAMFRTC

ACACB

776

O00763
CIIFGIVIVGMFCAA

NRG3

366

P56975
GCMIQLFFFCVCVIS

OR8D4

96

Q8NGM9
GCMFRVQFCKFDLIN

OR8G1

161

Q15617
GCMFRVQFCKFDVIN

OR8G5

196

Q8NG78
VLDAGIPMRDFVCAC

EXOSC4

146

Q9NPD3
IPMRDFVCACSAGFV

EXOSC4

151

Q9NPD3
FCVGVAECILLAFMA

OR10AD1

106

Q8NGE0
FFCMDTACVLIFTGE

KCND1

231

Q9NSA2
SFEGLCNEVRDMCSF

PRKCI

46

P41743
EAFQAGAMTCLICIA

NFXL1

151

Q6ZNB6
CLGDQSAALVGQMCF

GK3P

256

Q14409
CIFACEEMSGEVRFS

CHUK

241

O15111
DFECSLCMRLFFEPV

LONRF1

476

Q17RB8
LSDFIQEICCIAFAM

SPATA18

416

Q8TC71
GVREMCDACEATLFN

JMJD1C

1841

Q15652
CCMIFLGFADDVLNL

DPAGT1

106

Q9H3H5
FDQSNVLCSIFGICM

PTGFR

101

P43088
SFFCDLPLVIELACM

OR4K1

176

Q8NGD4
GVREMCDVCETTLFN

KDM3B

1026

Q7LBC6
FCDHCGEMLFGLVRQ

PRKD2

151

Q9BZL6
TAMGCITFLGVVLFC

LINGO3

531

P0C6S8
GRGVVCMSFFDIVLD

MIGA2

421

Q7L4E1
DFECALCMRLLFEPV

LONRF2

446

Q1L5Z9
VPMRALFCGVACALD

EXOSC5

146

Q9NQT4
EICCLASRYGALVFM

GCAT

216

O75600
CALQMFVFAGLADTE

OR5C1

101

Q8NGR4
TACGRCISGMFVFLT

GPM6B

126

Q13491
GEDAFRAVLCCMQLK

HELZ

91

P42694
ACAAQLGCFLAFMTA

OR8U9

96

P0C7N5
FMILNLSFCDLFICG

GPR75

81

O95800
FCVCTARTVVGFGMD

NELL1

11

Q92832
MCEFRVGQSLACEGL

PKD1L2

151

Q7Z442
FFFGAAECCLLATMA

OR10A4

106

Q9H209
ACTFGTTECFLLAAM

OR5T1

116

Q8NG75
LLMSGAVCFRVALAC

OR6S1

136

Q8NH40
CMAFQKDCEFFGIVN

ASB3

321

Q9Y575
LSACGGFEVCDDMVT

HEATR3

106

Q7Z4Q2
FVCNIGEDAELFMAL

DOCK5

231

Q9H7D0
SVLCSCRMEGFSLFL

LINC01555

86

Q8NAE3
CLFIQMEFCDKGTLE

EIF2AK2

361

P19525
TFCCLLMAEEAAVFA

FITM1

191

A5D6W6
CLNFDICQMCFLSGL

DYTN

246

A2CJ06
CGKTNCFMDIVVGFD

COL6A5

1186

A8TX70
ESAIFDAVMVCTGFL

FMO1

136

Q01740
MAPRGCIVAVFAIFC

IGFL1

1

Q6UW32
DLEEMNPLSISCFFC

C19orf67

186

A6NJJ6
GVDMSCLEGFATRCL

PRMT6

216

Q96LA8
CAEGFMLRGADIVRC

SELP

416

P16109
VVFCMDRALEFAPAC

DNAJC7

161

Q99615
GMCVDTLFLCFLEDL

SLC44A2

661

Q8IWA5
FVGARCEVNVDDCLM

DLK2

166

Q6UY11
FKCRCNSGFALDMEE

FBN2

1096

P35556
DVCGLSCISFNVLMV

IKZF3

121

Q9UKT9
CQCPAAMAFCFLETL

SEC22C

76

Q9BRL7
ADEFMGRCICQPSLE

DYSF

1236

O75923
MNDSLFCVVAAFGCF

DYNLT2B

126

Q8WW35
AFMALDGKREVVCLC

PTCHD3

536

Q3KNS1
FFCEIMAVLKLACAD

OR2A25

176

A4D2G3
ALGSTECLLLAVMCF

OR2B2

106

Q9GZK3
EMACTLLETCGRFLF

UPF2

701

Q9HAU5
FFEMLGQACLLDICQ

RP1

2096

P56715
ICLVFEFMEHGCLSD

ITK

431

Q08881
FFCDVPAMLLLACTD

OR2L13

176

Q8N349
FDSEGVIMCFGLCAR

MROH2A

721

A6NES4
VCVEFSLLEDAIGCM

RBM6

501

P78332
DLVVCVALGCDMFDC

QTRT1

266

Q9BXR0
VALGCDMFDCVFPTR

QTRT1

271

Q9BXR0
GCQEAFLTFLCVMCI

SLCO3A1

531

Q9UIG8
DPLGCRCFQMEEAVL

GNL3L

146

Q9NVN8
CALCFVIDLSMVTDG

SLC6A8

451

P48029
MGSGCRIECIFFSEF

NPRL2

1

Q8WTW4
EAETAGAIMAFFLCL

SLC29A1

426

Q99808
RLEEAMALFGFCSSC

SPTBN5

891

Q9NRC6
FETGCDFLFLEMFCL

SETDB1

646

Q15047
LEGHFDIVMCADCLF

CAMKMT

221

Q7Z624
VCFACMDGQEFRFAQ

CLTCL1

1256

P53675
CMAGVFSFACALGVV

CLRN1

11

P58418
MEAVVFVFSLLDCCA

CNIH4

1

Q9P003
MQREFGFLCDCTVAI

ZBTB25

16

P24278
IMAFDALVTFCEELG

RECQL5

396

O94762
RDSGMCLQAFVEAFF

TTLL11

701

Q8NHH1
ALCCVFISFVAGIAM

XKR6

476

Q5GH73
LAVGFAECMLRLVDC

WDR90

1691

Q96KV7
TDMAVFCLLCGKRFQ

ZBTB16

486

Q05516
LCSGFVRICMDEDGN

VWF

1871

P04275
MINADFCAGAVLISF

RHBG

126

Q9H310
CGAAFMDFLLEVQAA

TLR9

766

Q9NR96
ACLLVQDACGMFGEV

SPIDR

516

Q14159
DVNCSAVLRFFLCAM

SFRP4

66

Q6FHJ7
ACCFFFMVVLLGLDS

SLC6A13

376

Q9NSD5
SAVTCFGNIFVICMR

RXFP1

416

Q9HBX9
ASGMCLLFVAIFECI

SLC6A11

471

P48066
FVLQFMDRCFGLIES

PSME4

546

Q14997
MEVLQCDGCDFRAPS

ZNF462

1

Q96JM2
MRESQCVLGSFFTCL

TSPAN2

81

O60636
PIAVGSFCLFIFDMC

WLS

341

Q5T9L3
SFCLFIFDMCERGVQ

WLS

346

Q5T9L3
MQEPLFVEFADCCLG

ZNHIT3

131

Q15649
CECGKFFMDSCTLII

ZNF17

361

P17021
ELFTDKFCQVCGVML

ZMAT1

51

Q5H9K5
MPIRALCTICSDFFD

TRAIP

1

Q9BWF2
DICCMAADGRLVFAA

WDR36

126

Q8NI36
ACCETFGMRKSELFE

VAV3

81

Q9UKW4
AAERLCMGVDCTEIF

ZNF263

401

O14978
GFLCDCTVMVGSTQF

ZBTB3

71

Q9H5J0