Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	microfilament motor activity	MYH2 MYH3 MYH15 MYH13	1.37e-07	38	25	4	GO:0000146
GeneOntologyMolecularFunction	actin filament binding	TRIOBP MYH2 MYH3 MYH15 MYH13	8.02e-06	227	25	5	GO:0051015
GeneOntologyMolecularFunction	cytoskeletal motor activity	MYH2 MYH3 MYH15 MYH13	1.33e-05	118	25	4	GO:0003774
GeneOntologyMolecularFunction	histone H3K4 monomethyltransferase activity	KMT2C KMT2D	4.19e-05	8	25	2	GO:0140945
GeneOntologyMolecularFunction	protein-macromolecule adaptor activity	AMBRA1 KMT2C KMT2D CAMTA1 BRD1 GAB1 DMAP1 LPIN2	5.63e-05	1160	25	8	GO:0030674
GeneOntologyMolecularFunction	histone H3K4 trimethyltransferase activity	KMT2C KMT2D	6.73e-05	10	25	2	GO:0140999
GeneOntologyMolecularFunction	molecular adaptor activity	AMBRA1 KMT2C KMT2D CAMTA1 BRD1 GAB1 DMAP1 LPIN2	1.69e-04	1356	25	8	GO:0060090
GeneOntologyMolecularFunction	histone modifying activity	KMT2C KMT2D BRD1 DMAP1	1.76e-04	229	25	4	GO:0140993
GeneOntologyMolecularFunction	calmodulin binding	MYH2 MYH3 MYH15 MYH13	1.79e-04	230	25	4	GO:0005516
GeneOntologyMolecularFunction	actin binding	TRIOBP MYH2 MYH3 MYH15 MYH13	2.78e-04	479	25	5	GO:0003779
GeneOntologyMolecularFunction	histone H3K4 methyltransferase activity	KMT2C KMT2D	2.82e-04	20	25	2	GO:0042800
GeneOntologyMolecularFunction	transcription coregulator activity	KMT2C KMT2D CAMTA1 DMAP1 LPIN2	5.78e-04	562	25	5	GO:0003712
GeneOntologyMolecularFunction	histone H3 methyltransferase activity	KMT2C KMT2D	1.38e-03	44	25	2	GO:0140938
GeneOntologyMolecularFunction	histone acetyltransferase activity	BRD1 DMAP1	1.85e-03	51	25	2	GO:0004402
GeneOntologyMolecularFunction	peptide-lysine-N-acetyltransferase activity	BRD1 DMAP1	2.15e-03	55	25	2	GO:0061733
GeneOntologyMolecularFunction	peptide N-acetyltransferase activity	BRD1 DMAP1	2.55e-03	60	25	2	GO:0034212
GeneOntologyMolecularFunction	protein-lysine N-methyltransferase activity	KMT2C KMT2D	3.26e-03	68	25	2	GO:0016279
GeneOntologyMolecularFunction	lysine N-methyltransferase activity	KMT2C KMT2D	3.35e-03	69	25	2	GO:0016278
GeneOntologyMolecularFunction	histone methyltransferase activity	KMT2C KMT2D	3.55e-03	71	25	2	GO:0042054
GeneOntologyMolecularFunction	N-acetyltransferase activity	BRD1 DMAP1	4.26e-03	78	25	2	GO:0008080
GeneOntologyMolecularFunction	phosphatase activity	MYH3 SBF1 LPIN2	5.35e-03	287	25	3	GO:0016791
GeneOntologyMolecularFunction	transcription coactivator activity	KMT2C KMT2D LPIN2	6.21e-03	303	25	3	GO:0003713
GeneOntologyMolecularFunction	ATP-dependent activity	MYH2 MYH3 MYH15 MYH13	6.70e-03	614	25	4	GO:0140657
GeneOntologyMolecularFunction	N-acyltransferase activity	BRD1 DMAP1	7.18e-03	102	25	2	GO:0016410
GeneOntologyMolecularFunction	protein methyltransferase activity	KMT2C KMT2D	7.32e-03	103	25	2	GO:0008276
GeneOntologyMolecularFunction	acetyltransferase activity	BRD1 DMAP1	7.45e-03	104	25	2	GO:0016407
GeneOntologyMolecularFunction	N-methyltransferase activity	KMT2C KMT2D	7.59e-03	105	25	2	GO:0008170
GeneOntologyMolecularFunction	GTPase binding	TRIOBP AMBRA1 GAPVD1	9.96e-03	360	25	3	GO:0051020
GeneOntologyMolecularFunction	cytoskeletal protein binding	TRIOBP MYH2 MYH3 MYH15 MYH13	1.06e-02	1099	25	5	GO:0008092
GeneOntologyMolecularFunction	phosphoric ester hydrolase activity	MYH3 SBF1 LPIN2	1.20e-02	386	25	3	GO:0042578
GeneOntologyMolecularFunction	hydrolase activity, acting on glycosyl bonds	GALC TLR2	1.39e-02	144	25	2	GO:0016798
GeneOntologyCellularComponent	myosin filament	MYH2 MYH3 MYH15 MYH13	1.98e-08	25	25	4	GO:0032982
GeneOntologyCellularComponent	myosin II complex	MYH2 MYH3 MYH15 MYH13	3.19e-08	28	25	4	GO:0016460
GeneOntologyCellularComponent	myosin complex	MYH2 MYH3 MYH15 MYH13	6.93e-07	59	25	4	GO:0016459
GeneOntologyCellularComponent	muscle myosin complex	MYH2 MYH3 MYH13	8.37e-07	16	25	3	GO:0005859
GeneOntologyCellularComponent	actin cytoskeleton	TRIOBP FILIP1 MYH2 MYH3 MYH15 MYH13	4.83e-05	576	25	6	GO:0015629
GeneOntologyCellularComponent	MLL3/4 complex	KMT2C KMT2D	9.00e-05	12	25	2	GO:0044666
GeneOntologyCellularComponent	myofibril	MYH2 MYH3 MYH15 MYH13	2.90e-04	273	25	4	GO:0030016
GeneOntologyCellularComponent	contractile muscle fiber	MYH2 MYH3 MYH15 MYH13	3.65e-04	290	25	4	GO:0043292
GeneOntologyCellularComponent	histone methyltransferase complex	KMT2C KMT2D	3.61e-03	75	25	2	GO:0035097
GeneOntologyCellularComponent	transferase complex	AMBRA1 KMT2C KMT2D BRD1 DMAP1	5.05e-03	963	25	5	GO:1990234
GeneOntologyCellularComponent	histone acetyltransferase complex	BRD1 DMAP1	5.61e-03	94	25	2	GO:0000123
MousePheno	abnormal muscle precursor cell morphology	MYH3 GAB1	1.42e-05	4	22	2	MP:0012185
Domain	Myosin_N	MYH2 MYH3 MYH15 MYH13	3.37e-09	15	25	4	IPR004009
Domain	Myosin_N	MYH2 MYH3 MYH15 MYH13	3.37e-09	15	25	4	PF02736
Domain	Myosin_tail_1	MYH2 MYH3 MYH15 MYH13	7.54e-09	18	25	4	PF01576
Domain	Myosin_tail	MYH2 MYH3 MYH15 MYH13	7.54e-09	18	25	4	IPR002928
Domain	Myosin-like_IQ_dom	MYH2 MYH3 MYH15 MYH13	9.54e-09	19	25	4	IPR027401
Domain	-	MYH2 MYH3 MYH15 MYH13	9.54e-09	19	25	4	4.10.270.10
Domain	IQ	MYH2 MYH3 MYH15 CAMTA1 MYH13	1.35e-07	93	25	5	PS50096
Domain	MYOSIN_MOTOR	MYH2 MYH3 MYH15 MYH13	1.79e-07	38	25	4	PS51456
Domain	Myosin_head	MYH2 MYH3 MYH15 MYH13	1.79e-07	38	25	4	PF00063
Domain	Myosin_head_motor_dom	MYH2 MYH3 MYH15 MYH13	1.79e-07	38	25	4	IPR001609
Domain	MYSc	MYH2 MYH3 MYH15 MYH13	1.79e-07	38	25	4	SM00242
Domain	IQ	MYH2 MYH3 CAMTA1 MYH13	2.28e-06	71	25	4	PF00612
Domain	EPHD	KMT2C KMT2D BRD1	3.21e-06	22	25	3	PS51805
Domain	IQ	MYH2 MYH3 CAMTA1 MYH13	3.87e-06	81	25	4	SM00015
Domain	IQ_motif_EF-hand-BS	MYH2 MYH3 CAMTA1 MYH13	5.90e-06	90	25	4	IPR000048
Domain	Cortactin-binding_p2_N	FILIP1 FILIP1L	1.03e-05	4	25	2	IPR019131
Domain	CortBP2	FILIP1 FILIP1L	1.03e-05	4	25	2	PF09727
Domain	FYrich_C	KMT2C KMT2D	1.72e-05	5	25	2	IPR003889
Domain	FYrich_N	KMT2C KMT2D	1.72e-05	5	25	2	IPR003888
Domain	FYRC	KMT2C KMT2D	1.72e-05	5	25	2	SM00542
Domain	FYRN	KMT2C KMT2D	1.72e-05	5	25	2	SM00541
Domain	FYRN	KMT2C KMT2D	1.72e-05	5	25	2	PF05964
Domain	FYRC	KMT2C KMT2D	1.72e-05	5	25	2	PF05965
Domain	FYRC	KMT2C KMT2D	1.72e-05	5	25	2	PS51543
Domain	FYRN	KMT2C KMT2D	1.72e-05	5	25	2	PS51542
Domain	PHD	KMT2C KMT2D BRD1	1.34e-04	75	25	3	PF00628
Domain	Znf_PHD-finger	KMT2C KMT2D BRD1	1.57e-04	79	25	3	IPR019787
Domain	Post-SET_dom	KMT2C KMT2D	2.04e-04	16	25	2	IPR003616
Domain	PostSET	KMT2C KMT2D	2.04e-04	16	25	2	SM00508
Domain	POST_SET	KMT2C KMT2D	2.04e-04	16	25	2	PS50868
Domain	PHD	KMT2C KMT2D BRD1	2.23e-04	89	25	3	SM00249
Domain	Znf_PHD	KMT2C KMT2D BRD1	2.38e-04	91	25	3	IPR001965
Domain	ZF_PHD_2	KMT2C KMT2D BRD1	2.70e-04	95	25	3	PS50016
Domain	ZF_PHD_1	KMT2C KMT2D BRD1	2.79e-04	96	25	3	PS01359
Domain	Znf_FYVE_PHD	KMT2C KMT2D BRD1	9.68e-04	147	25	3	IPR011011
Domain	SET	KMT2C KMT2D	1.37e-03	41	25	2	PF00856
Domain	SET	KMT2C KMT2D	1.72e-03	46	25	2	SM00317
Domain	SET_dom	KMT2C KMT2D	2.03e-03	50	25	2	IPR001214
Domain	SET	KMT2C KMT2D	2.03e-03	50	25	2	PS50280
Domain	HMG_box	KMT2C KMT2D	2.27e-03	53	25	2	PF00505
Domain	HMG	KMT2C KMT2D	2.36e-03	54	25	2	SM00398
Domain	HMG_box_dom	KMT2C KMT2D	3.40e-03	65	25	2	IPR009071
Domain	PH	TRIOBP SBF1 GAB1	3.43e-03	229	25	3	PF00169
Domain	P-loop_NTPase	MYH2 MYH3 MYH15 CAMTA1 MYH13	4.75e-03	848	25	5	IPR027417
Domain	PH	TRIOBP SBF1 GAB1	5.89e-03	278	25	3	SM00233
Domain	PH_DOMAIN	TRIOBP SBF1 GAB1	5.95e-03	279	25	3	PS50003
Domain	PH_domain	TRIOBP SBF1 GAB1	6.01e-03	280	25	3	IPR001849
Domain	-	TRIOBP SBF1 GAB1	1.49e-02	391	25	3	2.30.29.30
Pathway	KEGG_VIRAL_MYOCARDITIS	MYH2 MYH3 MYH15 MYH13	1.62e-06	70	18	4	M12294
Pathway	KEGG_TIGHT_JUNCTION	MYH2 MYH3 MYH15 MYH13	2.03e-05	132	18	4	M11355
Pathway	REACTOME_CHROMATIN_MODIFYING_ENZYMES	KMT2C KMT2D BRD1 DMAP1	3.35e-04	272	18	4	M29619
Pubmed	Organization of human and mouse skeletal myosin heavy chain gene clusters is highly conserved.	MYH2 MYH3 MYH13	7.41e-09	6	26	3	10077619
Pubmed	A fast Myosin super enhancer dictates muscle fiber phenotype through competitive interactions with Myosin genes.	MYH2 MYH3 MYH13	1.30e-08	7	26	3	35210422
Pubmed	Mll3 and Mll4 Facilitate Enhancer RNA Synthesis and Transcription from Promoters Independently of H3K4 Monomethylation.	KMT2C KMT2D	5.37e-07	2	26	2	28483418
Pubmed	Loss of MLL3/4 decouples enhancer H3K4 monomethylation, H3K27 acetylation, and gene activation during embryonic stem cell differentiation.	KMT2C KMT2D	5.37e-07	2	26	2	36869380
Pubmed	Histone H3K4 monomethylation catalyzed by Trr and mammalian COMPASS-like proteins at enhancers is dispensable for development and viability.	KMT2C KMT2D	5.37e-07	2	26	2	28967912
Pubmed	The MLL3/4 H3K4 methyltransferase complex in establishing an active enhancer landscape.	KMT2C KMT2D	5.37e-07	2	26	2	34156443
Pubmed	Innate immune activation in the pathogenesis of a murine model of globoid cell leukodystrophy.	GALC TLR2	5.37e-07	2	26	2	24316110
Pubmed	Crucial roles of mixed-lineage leukemia 3 and 4 as epigenetic switches of the hepatic circadian clock controlling bile acid homeostasis in mice.	KMT2C KMT2D	5.37e-07	2	26	2	25346535
Pubmed	KMT2C/D COMPASS complex-associated diseases [KCDCOM-ADs]: an emerging class of congenital regulopathies.	KMT2C KMT2D	5.37e-07	2	26	2	31924266
Pubmed	Reduced Expression of Histone Methyltransferases KMT2C and KMT2D Correlates with Improved Outcome in Pancreatic Ductal Adenocarcinoma.	KMT2C KMT2D	5.37e-07	2	26	2	27280393
Pubmed	Association of KMT2C/D loss-of-function variants with response to immune checkpoint blockades in colorectal cancer.	KMT2C KMT2D	5.37e-07	2	26	2	36601880
Pubmed	Mutations of PTCH1, MLL2, and MLL3 are not frequent events in hepatoblastoma.	KMT2C KMT2D	1.61e-06	3	26	2	22183980
Pubmed	Filamin A interacting protein plays a role in proper positioning of callosal projection neurons in the cortex.	FILIP1 FILIP1L	1.61e-06	3	26	2	26655467
Pubmed	Remodeling of the enhancer landscape during macrophage activation is coupled to enhancer transcription.	KMT2C KMT2D	1.61e-06	3	26	2	23932714
Pubmed	HOXC6 Is transcriptionally regulated via coordination of MLL histone methylase and estrogen receptor in an estrogen environment.	KMT2C KMT2D	1.61e-06	3	26	2	21683083
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	TRIOBP AMBRA1 KMT2C GAPVD1 SBF1 DMAP1	2.14e-06	529	26	6	14621295
Pubmed	Crucial roles for interactions between MLL3/4 and INI1 in nuclear receptor transactivation.	KMT2C KMT2D	3.22e-06	4	26	2	19221051
Pubmed	Cancer gene mutation frequencies for the U.S. population.	KMT2C KMT2D	3.22e-06	4	26	2	34645806
Pubmed	MLL3/MLL4 are required for CBP/p300 binding on enhancers and super-enhancer formation in brown adipogenesis.	KMT2C KMT2D	3.22e-06	4	26	2	28398509
Pubmed	Comparative sequence analysis of the complete human sarcomeric myosin heavy chain family: implications for functional diversity.	MYH2 MYH13	3.22e-06	4	26	2	10388558
Pubmed	The MLL3/MLL4 branches of the COMPASS family function as major histone H3K4 monomethylases at enhancers.	KMT2C KMT2D	3.22e-06	4	26	2	24081332
Pubmed	Evaluation of embryonic and perinatal myosin gene mutations and the etiology of congenital idiopathic clubfoot.	MYH2 MYH3	3.22e-06	4	26	2	20357587
Pubmed	A subset of mixed lineage leukemia proteins has plant homeodomain (PHD)-mediated E3 ligase activity.	KMT2C KMT2D	3.22e-06	4	26	2	23129768
Pubmed	Impact of WIN site inhibitor on the WDR5 interactome.	KMT2C KMT2D SBF1	4.49e-06	43	26	3	33472061
Pubmed	Promotion of heat shock factor Hsf1 degradation via adaptor protein filamin A-interacting protein 1-like (FILIP-1L).	FILIP1 FILIP1L	5.37e-06	5	26	2	21784850
Pubmed	MLL3/MLL4-Associated PAGR1 Regulates Adipogenesis by Controlling Induction of C/EBPβ and C/EBPδ.	KMT2C KMT2D	5.37e-06	5	26	2	32601106
Pubmed	Developmental pattern of mouse skeletal myosin heavy chain gene transcripts in vivo and in vitro.	MYH2 MYH3	5.37e-06	5	26	2	3829126
Pubmed	Sequential accumulation of mRNAs encoding different myosin heavy chain isoforms during skeletal muscle development in vivo detected with a recombinant plasmid identified as coding for an adult fast myosin heavy chain from mouse skeletal muscle.	MYH2 MYH3	5.37e-06	5	26	2	6196357
Pubmed	Multigene family for sarcomeric myosin heavy chain in mouse and human DNA: localization on a single chromosome.	MYH2 MYH3	5.37e-06	5	26	2	6879174
Pubmed	Selective binding of the PHD6 finger of MLL4 to histone H4K16ac links MLL4 and MOF.	KMT2C KMT2D	5.37e-06	5	26	2	31127101
Pubmed	A PTIP-PA1 subcomplex promotes transcription for IgH class switching independently from the associated MLL3/MLL4 methyltransferase complex.	KMT2C KMT2D	5.37e-06	5	26	2	26744420
Pubmed	Type 3 and type 1 ryanodine receptors are localized in triads of the same mammalian skeletal muscle fibers.	MYH2 MYH3	8.05e-06	6	26	2	10444070
Pubmed	Distinct myogenic programs of embryonic and fetal mouse muscle cells: expression of the perinatal myosin heavy chain isoform in vitro.	MYH2 MYH3	8.05e-06	6	26	2	1728586
Pubmed	Spatial and temporal changes in myosin heavy chain gene expression in skeletal muscle development.	MYH2 MYH3	8.05e-06	6	26	2	10588881
Pubmed	Coactivator as a target gene specificity determinant for histone H3 lysine 4 methyltransferases.	KMT2C KMT2D	8.05e-06	6	26	2	17021013
Pubmed	Structural insights into trans-histone regulation of H3K4 methylation by unique histone H4 binding of MLL3/4.	KMT2C KMT2D	1.13e-05	7	26	2	30604749
Pubmed	ANKK1 is found in myogenic precursors and muscle fibers subtypes with glycolytic metabolism.	MYH2 MYH3	1.13e-05	7	26	2	29758057
Pubmed	Clustered PHD domains in KMT2/MLL proteins are attracted by H3K4me3 and H3 acetylation-rich active promoters and enhancers.	KMT2C KMT2D	1.13e-05	7	26	2	36598580
Pubmed	Diversity in transcriptional start site selection and alternative splicing affects the 5'-UTR of mouse striated muscle myosin transcripts.	MYH2 MYH3	1.13e-05	7	26	2	16819597
Pubmed	ASCOM controls farnesoid X receptor transactivation through its associated histone H3 lysine 4 methyltransferase activity.	KMT2C KMT2D	1.13e-05	7	26	2	19556342
Pubmed	H3.3K4M destabilizes enhancer H3K4 methyltransferases MLL3/MLL4 and impairs adipose tissue development.	KMT2C KMT2D	1.50e-05	8	26	2	30335158
Pubmed	Skirting the pitfalls: a clear-cut nomenclature for H3K4 methyltransferases.	KMT2C KMT2D	1.50e-05	8	26	2	23130995
Pubmed	The plasticity of WDR5 peptide-binding cleft enables the binding of the SET1 family of histone methyltransferases.	KMT2C KMT2D	1.50e-05	8	26	2	22266653
Pubmed	Four enzymes cooperate to displace histone H1 during the first minute of hormonal gene activation.	KMT2C KMT2D	1.50e-05	8	26	2	21447625
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	AMBRA1 GAPVD1 ZFC3H1 SBF1 DMAP1	1.67e-05	440	26	5	34244565
Pubmed	Structural basis for WDR5 interaction (Win) motif recognition in human SET1 family histone methyltransferases.	KMT2C KMT2D	1.93e-05	9	26	2	22665483
Pubmed	Acceleration of somitic myogenesis in embryos of myogenin promoter-MRF4 transgenic mice.	MYH2 MYH3	2.41e-05	10	26	2	8950513
Pubmed	MLL3/MLL4 methyltransferase activities control early embryonic development and embryonic stem cell differentiation in a lineage-selective manner.	KMT2C KMT2D	2.94e-05	11	26	2	37012455
Pubmed	Calcineurin is necessary for the maintenance but not embryonic development of slow muscle fibers.	MYH2 MYH3	2.94e-05	11	26	2	16024798
Pubmed	Dysregulation of nuclear receptor COUP-TFII impairs skeletal muscle development.	MYH2 MYH3	3.53e-05	12	26	2	28600496
Pubmed	Targeted Disruption of the Interaction between WD-40 Repeat Protein 5 (WDR5) and Mixed Lineage Leukemia (MLL)/SET1 Family Proteins Specifically Inhibits MLL1 and SETd1A Methyltransferase Complexes.	KMT2C KMT2D	3.53e-05	12	26	2	27563068
Pubmed	Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination.	KMT2C KMT2D	4.17e-05	13	26	2	17761849
Pubmed	The inhibition of differentiation caused by TGFbeta in fetal myoblasts is dependent upon selective expression of PKCtheta: a possible molecular basis for myoblast diversification during limb histogenesis.	MYH2 MYH3	4.17e-05	13	26	2	8948582
Pubmed	Histone demethylase JMJD2B coordinates H3K4/H3K9 methylation and promotes hormonally responsive breast carcinogenesis.	KMT2C KMT2D	4.17e-05	13	26	2	21502505
Pubmed	Inactivation of the myogenic bHLH gene MRF4 results in up-regulation of myogenin and rib anomalies.	MYH2 MYH3	4.17e-05	13	26	2	7797078
Pubmed	Contractile protein gene expression in primary myotubes of embryonic mouse hindlimb muscles.	MYH2 MYH3	4.17e-05	13	26	2	8404542
Pubmed	Failure of Myf5 to support myogenic differentiation without myogenin, MyoD, and MRF4.	MYH2 MYH3	4.17e-05	13	26	2	10694423
Pubmed	Ambra1 deficiency impairs mitophagy in skeletal muscle.	AMBRA1 MYH2	4.17e-05	13	26	2	35593053
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	KMT2C GAPVD1 KMT2D UBN2 DMAP1	4.81e-05	549	26	5	38280479
Pubmed	Distinct requirements for Gab1 in Met and EGF receptor signaling in vivo.	MYH2 GAB1	4.86e-05	14	26	2	17881575
Pubmed	Defective excitation-contraction coupling is partially responsible for impaired contractility in hindlimb muscles of Stac3 knockout mice.	MYH2 MYH3	4.86e-05	14	26	2	27184118
Pubmed	Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins.	KMT2C KMT2D	4.86e-05	14	26	2	12482968
Pubmed	Six homeoproteins and a Iinc-RNA at the fast MYH locus lock fast myofiber terminal phenotype.	MYH2 MYH3	5.61e-05	15	26	2	24852826
Pubmed	The BRCT-domain containing protein PTIP links PAX2 to a histone H3, lysine 4 methyltransferase complex.	KMT2C KMT2D	5.61e-05	15	26	2	17925232
Pubmed	H3K4 mono- and di-methyltransferase MLL4 is required for enhancer activation during cell differentiation.	KMT2C KMT2D	6.41e-05	16	26	2	24368734
Pubmed	MLL3 and MLL4 Methyltransferases Bind to the MAFA and MAFB Transcription Factors to Regulate Islet β-Cell Function.	KMT2C KMT2D	7.26e-05	17	26	2	26180087
Pubmed	Slow and fast fiber isoform gene expression is systematically altered in skeletal muscle of the Sox6 mutant, p100H.	MYH2 MYH3	7.26e-05	17	26	2	16124007
Pubmed	PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex.	KMT2C KMT2D	8.16e-05	18	26	2	17500065
Pubmed	Resetting the epigenetic balance of Polycomb and COMPASS function at enhancers for cancer therapy.	KMT2C KMT2D	1.01e-04	20	26	2	29785026
Pubmed	Targeted inactivation of MLL3 histone H3-Lys-4 methyltransferase activity in the mouse reveals vital roles for MLL3 in adipogenesis.	KMT2C KMT2D	1.01e-04	20	26	2	19047629
Pubmed	Distinct regulatory cascades govern extraocular and pharyngeal arch muscle progenitor cell fates.	MYH15 MYH13	1.01e-04	20	26	2	19531352
Pubmed	The histone H3-lysine 4-methyltransferase Mll4 regulates the development of growth hormone-releasing hormone-producing neurons in the mouse hypothalamus.	KMT2C KMT2D	1.01e-04	20	26	2	33431871
Pubmed	Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition.	KMT2C KMT2D	1.12e-04	21	26	2	27626377
Pubmed	A new role for the calcineurin/NFAT pathway in neonatal myosin heavy chain expression via the NFATc2/MyoD complex during mouse myogenesis.	MYH2 MYH3	1.23e-04	22	26	2	24301466
Pubmed	Structural basis for activity regulation of MLL family methyltransferases.	KMT2C KMT2D	1.23e-04	22	26	2	26886794
Pubmed	Interaction network of human early embryonic transcription factors.	KMT2C KMT2D UBN2 DMAP1	1.28e-04	351	26	4	38297188
Pubmed	Identification and characterization of a novel human PP1 phosphatase complex.	KMT2C KMT2D	2.47e-04	31	26	2	20516061
Pubmed	An Oct4-centered protein interaction network in embryonic stem cells.	KMT2C KMT2D DMAP1	2.61e-04	167	26	3	20362541
Pubmed	HOXA5 Participates in Brown Adipose Tissue and Epaxial Skeletal Muscle Patterning and in Brown Adipocyte Differentiation.	MYH2 MYH3	2.63e-04	32	26	2	33732701
Pubmed	Myosin heavy chain-embryonic regulates skeletal muscle differentiation during mammalian development.	MYH2 MYH3	2.80e-04	33	26	2	32094117
Pubmed	MLL4 is required after implantation, whereas MLL3 becomes essential during late gestation.	KMT2C KMT2D	2.80e-04	33	26	2	32439762
Pubmed	Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.	KMT2C KMT2D ZNF831 DMAP1	3.86e-04	469	26	4	27634302
Pubmed	Temporal regulation of the Mediator complex during muscle proliferation, differentiation, regeneration, aging, and disease.	MYH2 MYH3	3.91e-04	39	26	2	38690566
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	GAPVD1 STK32C BRD1 SBF1 GAB1	3.92e-04	861	26	5	36931259
Pubmed	ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation.	BRD1 DMAP1	4.54e-04	42	26	2	16387653
Pubmed	Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.	MYH2 MYH3 MYH15 GAPVD1 MYH13	5.05e-04	910	26	5	36736316
Pubmed	HOXA5 plays tissue-specific roles in the developing respiratory system.	MYH2 MYH3	5.45e-04	46	26	2	28827394
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	TRIOBP KMT2C CAMTA1	6.22e-04	225	26	3	12168954
Pubmed	The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets.	GAPVD1 SBF1 DMAP1	6.22e-04	225	26	3	25277244
Pubmed	Epigenetic-focused CRISPR/Cas9 screen identifies (absent, small, or homeotic)2-like protein (ASH2L) as a regulator of glioblastoma cell survival.	KMT2C KMT2D	6.44e-04	50	26	2	37974198
Pubmed	A systems-wide screen identifies substrates of the SCFβTrCP ubiquitin ligase.	AMBRA1 SBF1 LPIN2	6.80e-04	232	26	3	25515538
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	TRIOBP KMT2C ZFC3H1 SBF1 UBN2 DMAP1	6.90e-04	1497	26	6	31527615
Interaction	CDK3 interactions	MYH2 MYH3 MYH15 MYH13	1.12e-05	114	25	4	int:CDK3
Interaction	STK4 interactions	MYH2 MYH3 MYH15 MYH13	4.15e-05	159	25	4	int:STK4
Interaction	STK3 interactions	MYH2 MYH3 MYH15 MYH13	6.87e-05	181	25	4	int:STK3
Cytoband	22q13.33	BRD1 SBF1	2.14e-04	38	26	2	22q13.33
Cytoband	Ensembl 112 genes in cytogenetic band chr22q13	TRIOBP BRD1 SBF1	8.46e-04	330	26	3	chr22q13
Cytoband	Ensembl 112 genes in cytogenetic band chr17p13	MYH2 MYH3 MYH13	9.70e-04	346	26	3	chr17p13
Cytoband	17p13.1	MYH2 MYH3	2.04e-03	118	26	2	17p13.1
Cytoband	Ensembl 112 genes in cytogenetic band chr4q31	GAB1 TLR2	3.90e-03	164	26	2	chr4q31
GeneFamily	Myosin heavy chains	MYH2 MYH3 MYH15 MYH13	1.18e-09	15	19	4	1098
GeneFamily	PHD finger proteins	KMT2C KMT2D BRD1	1.09e-04	90	19	3	88
GeneFamily	Zinc fingers C2H2-type\|Lysine methyltransferases\|PR/SET domain family	KMT2C KMT2D	5.75e-04	34	19	2	487
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	TRIOBP SBF1 GAB1	1.23e-03	206	19	3	682
Coexpression	GSE25088_WT_VS_STAT6_KO_MACROPHAGE_ROSIGLITAZONE_STIM_UP	KMT2C GAPVD1 TLR2 FILIP1L	3.83e-05	194	26	4	M8019
Coexpression	GSE360_DC_VS_MAC_L_MAJOR_DN	MYH2 GAPVD1 GPR17 CAMTA1	4.23e-05	199	26	4	M5182
Coexpression	GSE40655_FOXO1_KO_VS_WT_NTREG_UP	KMT2C GAPVD1 KMT2D ZFC3H1	4.31e-05	200	26	4	M9439
ToppCell	Smart-seq2-blood_(Smart-seq2)-myeloid-myeloid_monocytic-classical_monocyte\|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	KMT2C MYH15 MYH13 TLR2	3.94e-06	186	26	4	23b8d51d20b05795a73892d3e20e0f9b6a207820
Drug	NSC339663	TRIOBP MYH2 MYH3 MYH13 GAB1	6.81e-06	250	25	5	CID000003892
Drug	fast white	MYH2 MYH3 MYH13	1.31e-05	42	25	3	CID000024008
Drug	formycin triphosphate	MYH2 MYH3 MYH13	2.35e-05	51	25	3	CID000122274
Drug	purealin	MYH2 MYH3 MYH13	3.47e-05	58	25	3	CID006419303
Drug	Methacycline hydrochloride [3963-95-9]; Up 200; 8.4uM; MCF7; HT_HG-U133A	AMBRA1 SBF1 FILIP1L LPIN2	5.85e-05	196	25	4	7321_UP
Drug	Griseofulvin [126-07-8]; Up 200; 11.2uM; PC3; HT_HG-U133A	MYH15 GPR17 GAB1 FILIP1L	5.96e-05	197	25	4	3664_UP
Drug	Cyproterone acetate [427-51-0]; Up 200; 9.6uM; PC3; HT_HG-U133A	MYH2 GAB1 TLR2 LPIN2	6.08e-05	198	25	4	4470_UP
Disease	dilated cardiomyopathy 1S (implicated_via_orthology)	MYH2 MYH3 MYH15 MYH13	7.04e-11	10	24	4	DOID:0110454 (implicated_via_orthology)
Disease	distal arthrogryposis type 2B3 (implicated_via_orthology)	MYH2 MYH3 MYH15 MYH13	7.04e-11	10	24	4	DOID:0111602 (implicated_via_orthology)
Disease	inclusion body myositis (implicated_via_orthology)	MYH2 MYH3 MYH15 MYH13	7.04e-11	10	24	4	DOID:3429 (implicated_via_orthology)
Disease	autosomal dominant hyaline body myopathy (implicated_via_orthology)	MYH2 MYH3 MYH15 MYH13	7.04e-11	10	24	4	DOID:0111269 (implicated_via_orthology)
Disease	congenital myopathy 6 (implicated_via_orthology)	MYH2 MYH3 MYH15 MYH13	7.04e-11	10	24	4	DOID:0080719 (implicated_via_orthology)
Disease	distal arthrogryposis type 2A (implicated_via_orthology)	MYH2 MYH3 MYH15 MYH13	7.04e-11	10	24	4	DOID:0111605 (implicated_via_orthology)
Disease	familial hypertrophic cardiomyopathy (implicated_via_orthology)	MYH2 MYH3 MYH15 MYH13	7.04e-11	10	24	4	DOID:0080326 (implicated_via_orthology)
Disease	distal arthrogryposis type 1 (implicated_via_orthology)	MYH2 MYH3 MYH15 MYH13	7.04e-11	10	24	4	DOID:0111596 (implicated_via_orthology)
Disease	distal myopathy (implicated_via_orthology)	MYH2 MYH3 MYH15 MYH13	1.66e-10	12	24	4	DOID:11720 (implicated_via_orthology)
Disease	myotonia congenita (implicated_via_orthology)	MYH2 MYH3 MYH15 MYH13	1.66e-10	12	24	4	DOID:2106 (implicated_via_orthology)
Disease	restrictive cardiomyopathy (implicated_via_orthology)	MYH2 MYH3 MYH15 MYH13	2.39e-10	13	24	4	DOID:397 (implicated_via_orthology)
Disease	distal arthrogryposis (implicated_via_orthology)	MYH2 MYH3 MYH15 MYH13	4.57e-10	15	24	4	DOID:0050646 (implicated_via_orthology)
Disease	myopathy (implicated_via_orthology)	MYH2 MYH3 MYH15 MYH13	6.39e-08	48	24	4	DOID:423 (implicated_via_orthology)
Disease	cardiomyopathy (implicated_via_orthology)	MYH2 MYH3 MYH15 MYH13	3.15e-07	71	24	4	DOID:0050700 (implicated_via_orthology)
Disease	dilated cardiomyopathy (implicated_via_orthology)	MYH2 MYH3 MYH15 MYH13	5.11e-07	80	24	4	DOID:12930 (implicated_via_orthology)
Disease	Kleefstra syndrome 2 (implicated_via_orthology)	KMT2C KMT2D	6.34e-07	2	24	2	DOID:0080598 (implicated_via_orthology)
Disease	Sezary Syndrome	KMT2C KMT2D	2.20e-04	27	24	2	C0036920
Disease	bullous pemphigoid	TLR2 LPIN2	3.50e-04	34	24	2	EFO_0007187
Disease	total hip arthroplasty, osteoarthritis	TRIOBP FILIP1	5.35e-04	42	24	2	EFO_0009806, MONDO_0005178
Disease	esophagus squamous cell carcinoma (is_implicated_in)	KMT2C KMT2D	6.14e-04	45	24	2	DOID:3748 (is_implicated_in)
Disease	Nonsyndromic Hearing Loss and Deafness, Autosomal Recessive	TRIOBP GAB1	7.89e-04	51	24	2	cv:CN043650
Disease	congenital heart disease (implicated_via_orthology)	KMT2C KMT2D	1.44e-03	69	24	2	DOID:1682 (implicated_via_orthology)
Disease	Nonsyndromic genetic hearing loss	TRIOBP GAB1	1.74e-03	76	24	2	cv:C5680182
Disease	reaction time measurement	AMBRA1 MYH15 KMT2D CAMTA1	1.83e-03	658	24	4	EFO_0008393
Disease	thalamus volume	GALC CAMTA1	2.17e-03	85	24	2	EFO_0006935

Protein segments in the cluster

Peptide	Gene	Start	Entry
RSWQWLPKSKMVPLG	BRD1	996	O95696
MWRAEGKWLPKTSRK	CAMTA1	1	Q9Y6Y1
WWAGSRKPPREMLKL	GPR17	6	Q13304
KTRWMKWEGKRVELP	AMBRA1	36	Q9C0C7
RPLNKKWRGMKWKKW	KMT2C	4346	Q8NEZ4
PPEKKLKRYAWKRRW	GAB1	16	Q13480
PWWRKRFVSAMPKAP	GAPVD1	976	Q14C86
KHWPWMKLFFKIKPL	MYH2	831	Q9UKX2
KKGAFMKPWKARWFV	SBF1	1771	O95248
KGAFNRAMKRWLWPK	OR12D1	291	P0DN82
WKGKMKPPAWYARLP	CCDC105	96	Q8IYK2
KLGSKKVRPWKWMPF	DMAP1	86	Q9NPF5
KVRPWKWMPFTNPAR	DMAP1	91	Q9NPF5
PVNRKLWIPWMKSKE	FILIP1L	856	Q4L180
WWLMKEAKKRNPNIT	GALC	131	P54803
RKSWIPWMRKRENGP	FILIP1	866	Q7Z7B0
VKNWPWMRLFFKIKP	MYH15	836	Q9Y2K3
KHWPWMKLFFKIKPL	MYH3	826	P11055
RWRRPDLLNFKKGWM	TRIOBP	1771	Q9H2D6
RPLFQWSKWKKRMGS	STK32C	56	Q86UX6
VKPLWPKGWMQARML	UBN2	646	Q6ZU65
LEKWLKNMKRDSWVP	THAP5	36	Q7Z6K1
WPWMNLFFKIKPLLK	MYH13	831	Q9UKX3
WKKGLPWRAKMSRGN	ZNF831	1266	Q5JPB2
MWAWLQAKRKPRKAP	TLR2	621	O60603
RKWKPKFWRKPISDN	ZFC3H1	1286	O60293
PPRLKKWKGVRWKRL	KMT2D	4976	O14686
MPKKSGRWWFWRKRE	LPIN2	551	Q92539