Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyBiologicalProcessimport across plasma membrane

PER2 SLC46A2 IRS2

1.55e-04230103GO:0098739
GeneOntologyBiologicalProcessestablishment of skin barrier

HRNR FLG2

1.72e-0441102GO:0061436
GeneOntologyBiologicalProcessglycogen biosynthetic process

PER2 IRS2

3.10e-0455102GO:0005978
GeneOntologyBiologicalProcessglucan biosynthetic process

PER2 IRS2

3.10e-0455102GO:0009250
GeneOntologyBiologicalProcessnegative regulation of lymphocyte apoptotic process

SLC46A2 IRS2

3.81e-0461102GO:0070229
GeneOntologyBiologicalProcesspolysaccharide biosynthetic process

PER2 IRS2

5.92e-0476102GO:0000271
GeneOntologyBiologicalProcessnegative regulation of leukocyte apoptotic process

SLC46A2 IRS2

7.57e-0486102GO:2000107
GeneOntologyBiologicalProcessregulation of lymphocyte apoptotic process

SLC46A2 IRS2

8.65e-0492102GO:0070228
GeneOntologyBiologicalProcessglycogen metabolic process

PER2 IRS2

1.00e-0399102GO:0005977
GeneOntologyBiologicalProcessglucan metabolic process

PER2 IRS2

1.04e-03101102GO:0044042
GeneOntologyBiologicalProcessregulation of organic acid transport

PER2 IRS2

1.08e-03103102GO:0032890
GeneOntologyBiologicalProcessenergy reserve metabolic process

PER2 IRS2

1.32e-03114102GO:0006112
GeneOntologyBiologicalProcesslymphocyte apoptotic process

SLC46A2 IRS2

1.51e-03122102GO:0070227
GeneOntologyBiologicalProcesspolysaccharide metabolic process

PER2 IRS2

1.61e-03126102GO:0005976
GeneOntologyBiologicalProcessorganic anion transport

PER2 SLC46A2 IRS2

1.63e-03515103GO:0015711
GeneOntologyBiologicalProcessregulation of leukocyte apoptotic process

SLC46A2 IRS2

1.72e-03130102GO:2000106
GeneOntologyBiologicalProcessregulation of circadian rhythm

PER2 USP9X

1.85e-03135102GO:0042752
GeneOntologyBiologicalProcesspositive regulation of immune system process

SLC46A2 USP9X IRS2 ROR2

2.05e-031242104GO:0002684
GeneOntologyCellularComponentkeratohyalin granule

HRNR FLG2

1.65e-06592GO:0036457
GeneOntologyCellularComponentcornified envelope

HRNR FLG2

3.81e-046992GO:0001533
DomainGOLGA6L

GOLGA6L19 GOLGA6L10 GOLGA6L4

5.26e-096133IPR026737
DomainGolgin_A

GOLGA6L19 GOLGA6L10 GOLGA6L4

2.14e-0718133IPR024858
DomainGOLGA2L5

GOLGA6L19 GOLGA6L10 GOLGA6L4

2.14e-0718133PF15070
DomainS100_CABP

HRNR FLG2

1.55e-0427132PS00303
DomainS_100

HRNR FLG2

1.55e-0427132PF01023
DomainS_100

HRNR FLG2

1.67e-0428132SM01394
DomainS100_Ca-bd_sub

HRNR FLG2

1.67e-0428132IPR013787
DomainS100/CaBP-9k_CS

HRNR FLG2

1.67e-0428132IPR001751
DomainEF_Hand_1_Ca_BS

HRNR FLG2

6.36e-03175132IPR018247
DomainEF_HAND_1

HRNR FLG2

8.55e-03204132PS00018
DomainEF_HAND_2

HRNR FLG2

1.09e-02231132PS50222
DomainEF_hand_dom

HRNR FLG2

1.10e-02232132IPR002048
Domain-

HRNR FLG2

1.37e-022611321.10.238.10
DomainEF-hand-dom_pair

HRNR FLG2

1.64e-02287132IPR011992
Pubmed

Defects of filaggrin-like proteins in both lesional and nonlesional atopic skin.

HRNR FLG2

3.87e-07313223403047
Pubmed

IRS-2 deubiquitination by USP9X maintains anchorage-independent cell growth via Erk1/2 activation in prostate carcinoma cell line.

USP9X IRS2

7.74e-07413230338032
Pubmed

Analysis of the DNA sequence and duplication history of human chromosome 15.

GOLGA6L19 GOLGA6L10 GOLGA6L4

1.12e-065613316572171
Pubmed

TRIM30 modulates Interleukin-22-regulated papillary thyroid Cancer cell migration and invasion by targeting Sox17 for K48-linked Polyubiquitination.

HRNR FLG2

1.54e-051613231823782
Pubmed

Variation in genes of the epidermal differentiation complex in German atopic dermatitis patients.

HRNR FLG2

2.70e-052113219601998
Pubmed

SARS-CoV-2 N Protein Antagonizes Stress Granule Assembly and IFN Production by Interacting with G3BPs to Facilitate Viral Replication.

NHSL1 HRNR FLG2

9.37e-0524513335652658
Pubmed

Extracellular Hsp90α and clusterin synergistically promote breast cancer epithelial-to-mesenchymal transition and metastasis via LRP1.

HRNR FLG2

1.21e-044413231273033
Pubmed

EGFR suppresses p53 function by promoting p53 binding to DNA-PKcs: a noncanonical regulatory axis between EGFR and wild-type p53 in glioblastoma.

HRNR FLG2

1.83e-045413235474131
Pubmed

A keratin scaffold regulates epidermal barrier formation, mitochondrial lipid composition, and activity.

HRNR FLG2

2.41e-046213226644517
Pubmed

Sleeve gastrectomy improves lipid dysmetabolism by downregulating the USP20-HSPA2 axis in diet-induced obese mice.

HRNR FLG2

2.57e-046413236636478
Pubmed

hnRNPA1 couples nuclear export and translation of specific mRNAs downstream of FGF-2/S6K2 signalling.

USP9X HRNR FLG2

2.59e-0434613325324306
Pubmed

Hypermethylation of UCHL1 Promotes Metastasis of Nasopharyngeal Carcinoma by Suppressing Degradation of Cortactin (CTTN).

HRNR FLG2

2.65e-046513232120844
Pubmed

SIRT5 is a proviral factor that interacts with SARS-CoV-2 Nsp14 protein.

HRNR FLG2

2.73e-046613236095012
InteractionDPRX interactions

HRNR FLG2

3.38e-0518102int:DPRX
Cytoband15q25.2

GOLGA6L10 GOLGA6L4

5.62e-054312215q25.2
Cytoband1q21.3

HRNR FLG2

4.18e-041171221q21.3
CytobandEnsembl 112 genes in cytogenetic band chr15q25

GOLGA6L10 GOLGA6L4

7.79e-04160122chr15q25
CytobandEnsembl 112 genes in cytogenetic band chr1q21

HRNR FLG2

4.81e-03404122chr1q21
GeneFamilyEF-hand domain containing|S100 fused type protein family

HRNR FLG2

3.59e-067821350
GeneFamilyEF-hand domain containing

HRNR FLG2

3.90e-0321982863
CoexpressionNAGASHIMA_NRG1_SIGNALING_UP

PER2 HIC2 IRS2

4.41e-05172113M11585
ToppCellFF-Differ-KC|World / shred by cell class for mouse tongue

SLC46A2 NHSL1 ROR2

1.72e-051791331526a130565a97c291a25a7a988089bffc1515c1
Diseasefacial morphology measurement

NHSL1 ROR2

8.33e-0346692EFO_0007841

Protein segments in the cluster

PeptideGeneStartEntry
SSYGQHGSGSSQSSG

FLG2

541

Q5D862
SSYGQHSSGSSQSSG

FLG2

616

Q5D862
HSSGSSQSSGYGQHG

FLG2

621

Q5D862
SRSGHSSYGQHGFGS

FLG2

686

Q5D862
SSYGQHGFGSSQSSG

FLG2

691

Q5D862
SQSSGYGQHGSSSGQ

FLG2

701

Q5D862
GQSSYGQHSSGSSQS

FLG2

766

Q5D862
GQHSSGSSQSSGYGQ

FLG2

771

Q5D862
HQSSYGQHGSGSSQS

FLG2

841

Q5D862
GSSQSSGYGQHGSSS

FLG2

851

Q5D862
SGYGQHGSSSGQTSG

FLG2

856

Q5D862
RSHQSSYGQHGSGSS

FLG2

916

Q5D862
GSGSSQSSGYGQHGS

FLG2

926

Q5D862
QHGSGSSQSSGYGQH

FLG2

1001

Q5D862
SSQSSGYGQHGSSSG

FLG2

1006

Q5D862
SGSSQSSGYGQHGSN

FLG2

1081

Q5D862
SSGYGQHGSNSGQTS

FLG2

1086

Q5D862
SSYGQHGTGSSQSSG

FLG2

1151

Q5D862
SESSYSGGGGHSSSE

NHSL1

541

Q5SYE7
HSGSSGYGSLGSNGS

PER2

476

O15055
SSSGQSSGYSQHGSG

HRNR

236

Q86YZ3
SSGYSQHGSGSGHSS

HRNR

241

Q86YZ3
SGHSSGYGQHGSRSG

HRNR

251

Q86YZ3
SSGSSSSYGQHGSGS

HRNR

276

Q86YZ3
SHGQHGSGSSYSYSR

HRNR

321

Q86YZ3
HESGSGQSSGYSKHG

HRNR

351

Q86YZ3
GQSSGYSKHGSGSGH

HRNR

356

Q86YZ3
YSKHGSGSGHSSSQG

HRNR

361

Q86YZ3
VSGSGYSSGFGHHES

HRNR

456

Q86YZ3
SSEHSSGYTQHGSGS

HRNR

471

Q86YZ3
SGYTQHGSGSGHSSG

HRNR

476

Q86YZ3
SGQSSGYGQHGSSSG

HRNR

591

Q86YZ3
GYGQHGSSSGHSSTH

HRNR

596

Q86YZ3
HGQHGSGSSQSSRYG

HRNR

636

Q86YZ3
GSDFGHSSSYGQHGS

HRNR

666

Q86YZ3
HSSSYGQHGSGSGWS

HRNR

671

Q86YZ3
GSGQSSGYSQHGSGS

HRNR

706

Q86YZ3
SGYSQHGSGSSHSSG

HRNR

711

Q86YZ3
QHGSSSGLSSSYGQH

HRNR

741

Q86YZ3
SGLSSSYGQHGSGSH

HRNR

746

Q86YZ3
SYGQHGSGSHQSSGH

HRNR

751

Q86YZ3
QGYSQHGSASGHFSS

HRNR

826

Q86YZ3
GFGHKSSSGQSSGYT

HRNR

931

Q86YZ3
SSSGQSSGYTQHGSG

HRNR

936

Q86YZ3
SSGYTQHGSGSGHSS

HRNR

941

Q86YZ3
SGHSSSYEQHGSRSG

HRNR

951

Q86YZ3
EQHGSSSGSSSSYGQ

HRNR

971

Q86YZ3
SSGSSSSYGQHGSGS

HRNR

976

Q86YZ3
SGYGQHGSSSGHSST

HRNR

1061

Q86YZ3
SHGQHGSGSSQSSGY

HRNR

1101

Q86YZ3
GFGHHESSSGQSSSY

HRNR

1166

Q86YZ3
QSSSYSQHGSGSGHS

HRNR

1176

Q86YZ3
SQHGSGSGHSSGYGQ

HRNR

1181

Q86YZ3
GSGHSSGYGQHGSRS

HRNR

1186

Q86YZ3
GERHGSSSGSSSHYG

HRNR

1206

Q86YZ3
SSSGSSSHYGQHGSG

HRNR

1211

Q86YZ3
SSHYGQHGSGSRQSS

HRNR

1216

Q86YZ3
SGHSSAYSQHGSGSG

HRNR

1291

Q86YZ3
GSGSGHSSSYGQHGS

HRNR

1366

Q86YZ3
HSSSYGQHGSGSGWS

HRNR

1371

Q86YZ3
SGHSSSYEQHGSRSG

HRNR

1421

Q86YZ3
SSGSSSSYGQHGSGS

HRNR

1446

Q86YZ3
SGYGQHGSSSGHSST

HRNR

1531

Q86YZ3
SHGQHGSGSSQSSGY

HRNR

1571

Q86YZ3
GFGHHESSSGQSSSY

HRNR

1636

Q86YZ3
QSSSYSQHGSGSGHS

HRNR

1646

Q86YZ3
SQHGSGSGHSSGYGQ

HRNR

1651

Q86YZ3
GSGHSSGYGQHGSRS

HRNR

1656

Q86YZ3
SGHSSAYSQHGSGSG

HRNR

1761

Q86YZ3
HGQHGSGSSQSSSYG

HRNR

1806

Q86YZ3
GSGSGHSSSYGQHGS

HRNR

1836

Q86YZ3
HSSSYGQHGSGSGWS

HRNR

1841

Q86YZ3
SSGYTQHGSGSGHSS

HRNR

1881

Q86YZ3
SGHSSSYEQHGSRSG

HRNR

1891

Q86YZ3
EQHGSSSGSSSSYGQ

HRNR

1911

Q86YZ3
SSGSSSSYGQHGSGS

HRNR

1916

Q86YZ3
SGYGQHGSSSGHSST

HRNR

2001

Q86YZ3
SHGQHGSGSSQSSGY

HRNR

2041

Q86YZ3
GFGHHESSSGQSSSY

HRNR

2106

Q86YZ3
QSSSYSQHGSGSGHS

HRNR

2116

Q86YZ3
SQHGSGSGHSSGYGQ

HRNR

2121

Q86YZ3
GSGHSSGYGQHGSRS

HRNR

2126

Q86YZ3
SSSGSSSRYGQHGSG

HRNR

2151

Q86YZ3
SGHSSAYSQHGSGSG

HRNR

2231

Q86YZ3
HGQHGSGSSQSSSYG

HRNR

2276

Q86YZ3
GSGSGHSSSYGQHGS

HRNR

2306

Q86YZ3
HSSSYGQHGSGSGWS

HRNR

2311

Q86YZ3
SSGYTQHGSGSGHSS

HRNR

2351

Q86YZ3
SGHSSSYEQHGSRSG

HRNR

2361

Q86YZ3
SSGSSSSYGQHGSGS

HRNR

2386

Q86YZ3
SGYGQHGSSSGHSST

HRNR

2471

Q86YZ3
SHGQHGSGSSQSSGY

HRNR

2511

Q86YZ3
GFGHHESSSGQSSSY

HRNR

2576

Q86YZ3
QSSSYSQHGSGSGHS

HRNR

2586

Q86YZ3
SQHGSGSGHSSGYGQ

HRNR

2591

Q86YZ3
GSGHSSGYGQHGSRS

HRNR

2596

Q86YZ3
GERHGSSSGSSSHYG

HRNR

2616

Q86YZ3
SSSGSSSHYGQHGSG

HRNR

2621

Q86YZ3
SSHYGQHGSGSRQSS

HRNR

2626

Q86YZ3
SGHSSAYSQHGSGSG

HRNR

2701

Q86YZ3
SHGRHGSGSGQSSSY

HRNR

2771

Q86YZ3
GSGSGQSSSYGQHGS

HRNR

2776

Q86YZ3
QSSSYGQHGSGSGQS

HRNR

2781

Q86YZ3
GSGQSSGYSQHGSGS

HRNR

2791

Q86YZ3
NGSSPDTATSGGYHS

GOLGA6L3

51

A6NEY3
NGSSPDTATSGGYHS

GOLGA6L4

51

A6NEF3
NGSSPDTATSGGYHS

GOLGA6L10

51

A6NI86
NGSSPDTATSGGYHS

GOLGA6L19

51

H0YKK7
GSLSSSSGHGSGSYP

IRS2

446

Q9Y4H2
QSGSEGGSGHASAHY

HIC2

411

Q96JB3
DSSTGSPGNHGNHYS

USP9X

981

Q93008
SHHSGSGSTSTGYVT

ROR2

861

Q01974
SGGHSSSSNSYGQSH

RBMXL3

531

Q8N7X1
GHDSSSQSDHYGGGG

RBMXL3

731

Q8N7X1
ASYGTGGSSNHSASP

SLC46A2

46

Q9BY10