Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionsemaphorin receptor activity

PLXNB1 PLXND1

3.00e-0512142GO:0017154
GeneOntologyMolecularFunctionmetalloendopeptidase activity

ADAM20 ADAMTSL2

3.11e-03120142GO:0004222
GeneOntologyMolecularFunctionintegrin binding

ADAM20 DST

6.48e-03175142GO:0005178
GeneOntologyMolecularFunctioncell adhesion molecule binding

ADAM20 DST PLEC

7.64e-03599143GO:0050839
GeneOntologyMolecularFunctionmetallopeptidase activity

ADAM20 ADAMTSL2

8.39e-03200142GO:0008237
GeneOntologyMolecularFunctiontransmembrane signaling receptor activity

ADGRG4 ADGRA1 PLXNB1 PLXND1

1.21e-021353144GO:0004888
GeneOntologyBiologicalProcesshemidesmosome assembly

DST PLEC

6.41e-066142GO:0031581
GeneOntologyCellularComponenthemidesmosome

DST PLEC

1.96e-0511132GO:0030056
GeneOntologyCellularComponentsemaphorin receptor complex

PLXNB1 PLXND1

2.77e-0513132GO:0002116
HumanPhenoAbnormal dermoepidermal hemidesmosome morphology

DST PLEC

6.33e-051162HP:0032449
HumanPhenoAbnormal dermoepidermal junction morphology

DST PLEC

7.59e-051262HP:0031538
HumanPhenoScarring

ADAMTSL2 DST PLEC

1.49e-0410263HP:0100699
Domain-

DST PLEC

6.70e-0661323.90.1290.10
DomainPlectin_repeat

DST PLEC

9.37e-067132IPR001101
DomainPlectin

DST PLEC

9.37e-067132PF00681
DomainPLEC

DST PLEC

9.37e-067132SM00250
DomainPlexin

PLXNB1 PLXND1

1.61e-059132IPR031148
DomainPlexin_cytopl

PLXNB1 PLXND1

1.61e-059132PF08337
DomainPlexin_cytoplasmic_RasGAP_dom

PLXNB1 PLXND1

1.61e-059132IPR013548
DomainACTININ_2

DST PLEC

1.12e-0423132PS00020
DomainActinin_actin-bd_CS

DST PLEC

1.12e-0423132IPR001589
DomainACTININ_1

DST PLEC

1.12e-0423132PS00019
DomainIPT

PLXNB1 PLXND1

1.55e-0427132SM00429
DomainSpectrin_repeat

DST PLEC

1.80e-0429132IPR002017
DomainTIG

PLXNB1 PLXND1

2.06e-0431132PF01833
DomainSema

PLXNB1 PLXND1

2.06e-0431132SM00630
DomainSemap_dom

PLXNB1 PLXND1

2.06e-0431132IPR001627
DomainSEMA

PLXNB1 PLXND1

2.06e-0431132PS51004
DomainSema

PLXNB1 PLXND1

2.06e-0431132PF01403
DomainPSI

PLXNB1 PLXND1

2.19e-0432132PF01437
DomainSpectrin/alpha-actinin

DST PLEC

2.19e-0432132IPR018159
DomainIPT

PLXNB1 PLXND1

2.19e-0432132IPR002909
DomainSPEC

DST PLEC

2.19e-0432132SM00150
DomainPlexin_repeat

PLXNB1 PLXND1

2.19e-0432132IPR002165
DomainGPCR_2_secretin-like_CS

ADGRG4 ADGRA1

2.48e-0434132IPR017983
DomainPSI

PLXNB1 PLXND1

4.16e-0444132IPR016201
DomainPSI

PLXNB1 PLXND1

4.55e-0446132SM00423
Domain7tm_2

ADGRG4 ADGRA1

5.38e-0450132PF00002
DomainG_PROTEIN_RECEP_F2_2

ADGRG4 ADGRA1

5.38e-0450132PS00650
DomainGPCR_2-like

ADGRG4 ADGRA1

7.74e-0460132IPR017981
DomainGPCR_2_secretin-like

ADGRG4 ADGRA1

7.74e-0460132IPR000832
DomainG_PROTEIN_RECEP_F2_4

ADGRG4 ADGRA1

8.00e-0461132PS50261
DomainCH

DST PLEC

9.08e-0465132SM00033
DomainCH

DST PLEC

1.05e-0370132PF00307
Domain-

DST PLEC

1.08e-03711321.10.418.10
DomainCH

DST PLEC

1.14e-0373132PS50021
DomainCH-domain

DST PLEC

1.21e-0375132IPR001715
DomainRho_GTPase_activation_prot

PLXNB1 PLXND1

1.66e-0388132IPR008936
DomainIg_E-set

PLXNB1 PLXND1

2.30e-03104132IPR014756
PathwayREACTOME_TYPE_I_HEMIDESMOSOME_ASSEMBLY

DST PLEC

1.30e-05992MM15117
PathwayREACTOME_TYPE_I_HEMIDESMOSOME_ASSEMBLY

DST PLEC

1.99e-051192M27372
PathwayREACTOME_RND2_GTPASE_CYCLE

PLXND1 DST

3.23e-044392M41827
PathwayREACTOME_RND2_GTPASE_CYCLE

PLXND1 DST

3.38e-044492MM15678
PathwayREACTOME_SEMAPHORIN_INTERACTIONS

PLXNB1 PLXND1

4.55e-045192MM14967
PathwayREACTOME_ASSEMBLY_OF_COLLAGEN_FIBRILS_AND_OTHER_MULTIMERIC_STRUCTURES

DST PLEC

6.50e-046192M27103
PathwayREACTOME_SEMAPHORIN_INTERACTIONS

PLXNB1 PLXND1

7.16e-046492M7923
PathwayWP_ALPHA_6_BETA_4_INTEGRIN_SIGNALING_PATHWAY

DST PLEC

7.61e-046692MM15925
PathwayREACTOME_CELL_JUNCTION_ORGANIZATION

DST PLEC

9.30e-047392MM15126
PathwayREACTOME_COLLAGEN_FORMATION

DST PLEC

1.41e-039092M631
PathwayREACTOME_CELL_CELL_COMMUNICATION

DST PLEC

1.60e-039692MM14592
PathwayREACTOME_RHO_GTPASE_CYCLE

PLXNB1 PLXND1 DST

2.19e-0343993MM15595
PathwayREACTOME_RHO_GTPASE_CYCLE

PLXNB1 PLXND1 DST

2.35e-0345093M27078
PathwayREACTOME_CELL_JUNCTION_ORGANIZATION

DST PLEC

2.37e-0311792M19248
PathwayREACTOME_CELL_CELL_COMMUNICATION

DST PLEC

4.11e-0315592M522
PathwayREACTOME_SIGNALING_BY_RHO_GTPASES_MIRO_GTPASES_AND_RHOBTB3

PLXNB1 PLXND1 DST

6.62e-0364993MM15690
PathwayREACTOME_SIGNALING_BY_RHO_GTPASES_MIRO_GTPASES_AND_RHOBTB3

PLXNB1 PLXND1 DST

8.84e-0372093M41838
PathwayREACTOME_DISEASES_OF_METABOLISM

SI ADAMTSL2

1.04e-0225092M27554
PathwayREACTOME_NERVOUS_SYSTEM_DEVELOPMENT

PLXNB1 PLXND1

1.13e-0226192MM15676
PathwayREACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION

DST PLEC

1.47e-0230092M610
Pubmed

BPAG1 isoform-b: complex distribution pattern in striated and heart muscle and association with plectin and alpha-actinin.

DST PLEC

5.21e-07315219932097
Pubmed

Role of binding of plectin to the integrin beta4 subunit in the assembly of hemidesmosomes.

DST PLEC

1.04e-06415214668477
Pubmed

The N terminus of the transmembrane protein BP180 interacts with the N-terminal domain of BP230, thereby mediating keratin cytoskeleton anchorage to the cell surface at the site of the hemidesmosome.

DST PLEC

3.64e-06715210637308
Pubmed

Epidermolysis Bullosa Simplex

DST PLEC

4.85e-06815220301543
Pubmed

Analysis of the interactions between BP180, BP230, plectin and the integrin alpha6beta4 important for hemidesmosome assembly.

DST PLEC

6.24e-06915212482924
Pubmed

Current insights into the formation and breakdown of hemidesmosomes.

DST PLEC

9.53e-061115216757171
Pubmed

The tetraspan molecule CD151, a novel constituent of hemidesmosomes, associates with the integrin alpha6beta4 and may regulate the spatial organization of hemidesmosomes.

DST PLEC

9.53e-061115210811835
Pubmed

Interaction of the bullous pemphigoid antigen 1 (BP230) and desmoplakin with intermediate filaments is mediated by distinct sequences within their COOH terminus.

DST PLEC

9.53e-061115212802069
Pubmed

Transmembrane semaphorin signalling controls laminar stratification in the mammalian retina.

PLXNB1 PLXND1

1.14e-051215221270798
Pubmed

Cytoplasmic plaque formation in hemidesmosome development is dependent on SoxF transcription factor function.

DST PLEC

1.35e-051315222962592
Pubmed

Cell cycle and adhesion defects in mice carrying a targeted deletion of the integrin beta4 cytoplasmic domain.

DST PLEC

1.35e-05131529670011
Pubmed

Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates.

PLXNB1 PLXND1

1.35e-051315210520995
Pubmed

Plexin-A3 mediates semaphorin signaling and regulates the development of hippocampal axonal projections.

PLXNB1 PLXND1

2.35e-051715211683995
Pubmed

Semaphorin signaling facilitates cleft formation in the developing salivary gland.

PLXNB1 PLXND1

2.35e-051715217626059
Pubmed

Biological, clinical and population relevance of 95 loci for blood lipids.

TYW1B FER1L4 PLEC

3.18e-0514615320686565
Pubmed

The human and mouse repertoire of the adhesion family of G-protein-coupled receptors.

ADGRG4 ADGRA1

7.00e-052915215203201
Pubmed

International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors.

ADGRG4 ADGRA1

9.10e-053315225713288
Pubmed

Discovery and refinement of loci associated with lipid levels.

TYW1B FER1L4 PLEC

9.49e-0521115324097068
Pubmed

TrkB-dependent EphrinA reverse signaling regulates callosal axon fasciculate growth downstream of Neurod2/6.

PLXNB1 PLXND1

1.86e-044715235462405
Pubmed

An extracellular biochemical screen reveals that FLRTs and Unc5s mediate neuronal subtype recognition in the retina.

PLXNB1 PLXND1

2.27e-045215226633812
Pubmed

EB1-binding-myomegalin protein complex promotes centrosomal microtubules functions.

DST PLEC

3.34e-046315229162697
GeneFamilyEF-hand domain containing|Plakins

DST PLEC

7.70e-068102939
GeneFamilyPlexins

PLXNB1 PLXND1

9.89e-069102683
ToppCellP07-Endothelial-large_vessel_endothelial_cell|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

PLXND1 DST PLEC

3.30e-05191153d162917816dd2e4767c97447c1cddae9397713ab
ToppCellControl_saline|World / Treatment groups by lineage, cell group, cell type

ADAMTSL2 DST PLEC

3.73e-0519915311c9c1779caceb725ecccf3f23b7d4e6dbd1af64
ToppCellControl_saline-Endothelial|Control_saline / Treatment groups by lineage, cell group, cell type

ADAMTSL2 DST PLEC

3.79e-052001533372c488a39fe812fa94e4f0564594186fea3db5
ToppCellControl_saline-Endothelial-Endothelial|Control_saline / Treatment groups by lineage, cell group, cell type

ADAMTSL2 DST PLEC

3.79e-05200153e77eba6172cabf85b8028638ed35299f2f079cd8
ToppCellileum-Absorptive_Enterocytes|ileum / shred on tissue and cell subclass

SI DST

8.44e-0541152650cec538c6acd92f45d804b3c94248c6231aa21
ToppCell356C-Lymphocytic-NK_cells-NK_cell_B1|NK_cells / Donor, Lineage, Cell class and subclass (all cells)

ADAM20 PLXNB1

3.91e-04881521ca0e16981e88030987412e12838a9797b97b9c9
ToppCell356C-Lymphocytic-NK_cells-NK_cell_B1|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

ADAM20 PLXNB1

5.04e-04100152cb0deaf1c33d2789417e93cc01d94e34a611d20a
ToppCellTCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Acinar_Adenocarcinoma-4|TCGA-Lung / Sample_Type by Project: Shred V9

ADGRG4 FER1L4

5.34e-041031520cdd2ac33de303ba6883a090f6909582a4c75059
ToppCellLPS-IL1RA-Myeloid-Myeloid_granulocytic-Neutrophils|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SI PLXNB1

7.00e-041181526053e19d040fb394f9c270361af07b0c5a4d47db
ToppCellLPS-IL1RA-Myeloid-Myeloid_granulocytic|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SI PLXNB1

7.00e-04118152811e8521129914eef46785a4227c1860e77d9096
ToppCellTCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Acinar_Adenocarcinoma-7|TCGA-Lung / Sample_Type by Project: Shred V9

SI ADAMTSL2

8.49e-041301520219d0d5d21df08f816569c7eb34f1bfa095d29a
ToppCellfrontal_cortex-Neuronal-glutamatergic_neuron-L5_IT-L5_IT_ALM_Tmem163_Dmrtb1|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ADAMTSL2 PLXND1

9.28e-041361520376c2907b869c7d42f57af7f65ffdd6246c4d27
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW16-OPC_related|GW16 / Sample Type, Dataset, Time_group, and Cell type.

PLAC8L1 PLEC

1.01e-03142152d2d150e3019a5b7b143e50b1c1c2b6764abf36bf
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW16-OPC_related-Oligodendrocyte/OPC|GW16 / Sample Type, Dataset, Time_group, and Cell type.

PLAC8L1 PLEC

1.01e-0314215243e72e4b9ae33768672ef90c8bbfd2ca1818c746
ToppCellfrontal_cortex-Neuronal-glutamatergic_neuron-L5_IT-L5_IT_ALM_Tnc|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ADAMTSL2 PLXND1

1.19e-031541520066b2b8cfc74603e97f271ef5efc7ec512110dc
ToppCellE16.5-samps-Endothelial-Immature_fetal_endothelial-Matrix_Endothelial|E16.5-samps / Age Group, Lineage, Cell class and subclass

PLXND1 DST

1.19e-03154152928f49839b046b90c2f942458f3e365ddc4e0bc9
ToppCell10x5'-Lung-Lymphocytic_T_CD4-T_CD4/CD8|Lung / Manually curated celltypes from each tissue

PLAC8L1 PLXNB1

1.22e-0315615210d191e29b16cae8238e8df6c0ff38882253f34e
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-L2/3_IT-L2/3_IT_VISp_Adamts2|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ADAMTSL2 PLXND1

1.22e-031561522cd007b423c2395c5ce331902e7f27c805755eb3
ToppCell343B-Myeloid-Macrophage-SPP1+_Macrophage|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

TYW1B ADAMTSL2

1.23e-031571524183dbed6b31ebe13ef33eb19ba6d0fb4f625953
ToppCellfacs-Brain_Myeloid-Striatum_-18m-Myeloid-macrophage|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLXND1 PLEC

1.23e-031571529d4308312301cb922f156a7b6aededc9e1c62807
ToppCellTCGA-Bladder-Primary_Tumor-Urothelial_Carcinoma-Papillary_Muscle_Invasive_Urothelial_Carcinoma|TCGA-Bladder / Sample_Type by Project: Shred V9

FER1L4 PLXNB1

1.25e-03158152dc559503bab3ec1b9ea54ef2e896d1be33e5344c
ToppCell343B-Myeloid-Macrophage-SPP1+_Macrophage|Macrophage / Donor, Lineage, Cell class and subclass (all cells)

TYW1B ADAMTSL2

1.25e-03158152de65af8d3b8514b17978155f31975e2347b75251
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-high_Fibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ADAMTSL2 PLXND1

1.26e-03159152cbb331eb689d8cea9e1146ba85e0a05d23301c47
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-high_Fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ADAMTSL2 PLXND1

1.26e-03159152330ecbba97d47bc818a5e8d1d84b05d056bd831e
ToppCellTransplant_Alveoli_and_parenchyma-Epithelial-Type_1_alveolar|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X

DST PLEC

1.28e-0316015258ed3a074932ccc951e07868dfdc61b99ae1cc2b
ToppCell368C-Myeloid-Macrophage-SPP1+_Macrophage|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

PLAC8L1 PLEC

1.28e-031601526d941e584360975e1fdbb2fc67af8e31f18759d8
ToppCellTCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Oligoastrocytoma|TCGA-Brain / Sample_Type by Project: Shred V9

DST PLEC

1.30e-03161152347edb0de10850b7d16c40945751033289289c9b
ToppCellwk_20-22-Hematologic-Myeloid-HSC/ELP|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

PLAC8L1 RNF220

1.34e-031641523c07d8f53511f269540bf032738a4ada35650b18
ToppCell5'-GW_trimst-2-LargeIntestine-Epithelial-neuro-epithelial-EECs|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ADAM20 PLXNB1

1.36e-031651524b4e75ad0eb0a6b00c30a000ec6267e23ba2e496
ToppCellPND14-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PLXND1 DST

1.38e-031661527a45785a40b7425f97be67bab1c5ceb69b2bd85a
ToppCellPND14-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PLXND1 DST

1.38e-03166152bbd382812f8a84a5d99888de2d7cca3a8b5e4695
ToppCellE16.5-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

DST PLEC

1.39e-0316715226cd8ee5e826e71eaf58d10a906543a6932fb3f9
ToppCellE16.5-Endothelial-Endothelial_lymphatic|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

DST PLEC

1.39e-03167152b93103a868fba63a8910bffb690a6242b9252833
ToppCellE16.5-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

DST PLEC

1.39e-03167152fcd583b1efd0ac883379982ea8e6c54f2c0be268
ToppCellE16.5-Endothelial-Endothelial_lymphatic-Lymphatic_EC|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

DST PLEC

1.39e-03167152f6bc63138b7239211fa5f27a8dc799b6e022c0f8
ToppCellkidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell__prolif|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ADAM20 PLXND1

1.41e-0316815237249f38f8f04ec5743097259de67b106ca2b02f
ToppCell3'-GW_trimst-2-SmallIntestine-Epithelial-neuro-epithelial-I_cells_(CCK+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RNF220 ADGRG4

1.41e-03168152f3164a85e5630ee8a745c6dba298e1f94ba4d5b8
ToppCell3'-GW_trimst-2-SmallIntestine-Epithelial-neuro-epithelial-EECs|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PLAC8L1 SI

1.44e-03170152fcaa32607bcbd8be6f040f9487c3d71e976e1077
ToppCellPBMC-Severe-Myeloid-cDC-cDC-cDC_0|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SI DST

1.44e-031701527bba77ae34a0259fad6ee98cf665ff50f77a1328
ToppCellileum|World / shred on tissue and cell subclass

SI DST

1.44e-031701529f1211bd4287620e19a59f21e6ecdca3e42e0260
ToppCell10x_3'_v3-spleen_(10x_3'_v3)-lymphocytic-innate_lymphocytic-innate_lymphoid_cell|spleen_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

B3GALT5-AS1 DST

1.44e-031701526c65ddb496030bb479ef346cc37a9d4dfa6b824f
ToppCellPBMC-Severe-Myeloid-cDC-cDC-cDC_0|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

SI DST

1.44e-03170152a43b977a7fe745536cf96b7c080397d9fa73086b
ToppCellCOVID-19_Severe-NK_CD56bright|COVID-19_Severe / Disease condition and Cell class

PLXND1 DST

1.46e-031711525810f790012a0750ca3378595514f66a99f123be
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_3-Exc_L3_THEMIS_PLA2G7|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

FER1L4 B3GALT5-AS1

1.48e-031721521d086e00cd549459d70e1d3b468d5ab6379f3bee
ToppCellfacs-Trachea-3m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l15|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ADGRA1 ADAMTSL2

1.48e-03172152de4961f4037c439d3e0ec706a257b0ec17f4d5be
ToppCell356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_6|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

TYW1B PLXND1

1.48e-03172152a9e13aa36087170dadca421ba9de588e5a1cf715
ToppCell368C-Myeloid-Macrophage-SPP1+_Macrophage|368C / Donor, Lineage, Cell class and subclass (all cells)

PLAC8L1 PLEC

1.49e-03173152bba8265a58f8f5659dc7b9da2fe27b15033fce34
ToppCellPND07-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_prolif|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

TSTD2 PLXND1

1.49e-031731524968712af1cca8c932abd3323631d7dcaffd4a66
ToppCellsystemic_lupus_erythematosus-flare-Myeloid-conventional_dendritic_cell-male|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

TSTD2 DST

1.53e-03175152c58a1f02d1e559d3638fe1500e960e82a8a7187b
ToppCell5'-GW_trimst-2-SmallIntestine-Epithelial-neuro-epithelial-I_cells_(CCK+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ADGRG4 ADGRA1

1.53e-03175152c031da47ca63d1133e13530cbf779df9435e22cb
ToppCellE16.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PLXND1 PLEC

1.55e-0317615277516048aefbe1f48e825052756df0c310c1c486
ToppCellE16.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PLXND1 PLEC

1.55e-0317615296779273b94345250cf53ba671203345b43d9e00
ToppCellControl-Myeloid-MoAM2,_CCL18|Myeloid / Condition, Lineage and Cell class

PLXNB1 PLXND1

1.56e-03177152470f54fe2b21c7350ea471e02039461a3808f700
ToppCell5'-GW_trimst-1.5-SmallIntestine-Epithelial-neuro-epithelial-EECs|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ADAM20 ADGRG4

1.56e-031771525bccc7a74019eae8afd977a9c9134d884857ac27
ToppCelldroplet-Heart-HEART-1m-Mesenchymal-coronary_vascular_endothelial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RNF220 PLXND1

1.60e-03179152dd94ebe69ade6f51b94058abe066216f0de9feda
ToppCellAT1_cells-Cryobiopsy_01|World / lung cells shred on cell class, cell subclass, sample id

PLXNB1 DST

1.60e-031791521603117b52623663458a977c94bf7f9f6c1114b8
ToppCellfacs-Lung-18m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l25|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PLXND1 DST

1.62e-0318015267c5068b660cd5e727a665cefe3bd5f8ae887221
ToppCell3'-Pediatric_IBD-SmallIntestine-Epithelial-Tuft-related-BEST4+_epithelial|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SI ADGRG4

1.62e-031801527c7c4d64ff99d0710a7d19d8bc29fc9217394db1
ToppCellPND10-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PLXND1 DST

1.63e-031811524d7793026373cbcf04b15c77f95f1025d07d4c00
ToppCell3'-GW_trimst-1.5-SmallIntestine-Epithelial-Tuft-related|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SI ADGRG4

1.63e-031811521d3d1b5a6efe9cedd03b7e0b5684df97f0246729
ToppCell3'-GW_trimst-1.5-SmallIntestine-Epithelial-Tuft-related-BEST4+_epithelial|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SI ADGRG4

1.63e-031811520069e8308de932df43660bbe926637c57b8bf7f6
ToppCell5'-GW_trimst-1-SmallIntestine-Epithelial-mature_enterocytic-Enterocyte|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SI ADAM20

1.63e-03181152c1203787cc3f968147fabdd3c646a04be96f6552
ToppCell5'-GW_trimst-1-SmallIntestine-Epithelial-mature_enterocytic|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SI ADAM20

1.63e-03181152f7258af89f4cc89446ff6754bdaa769320af95d6
ToppCellfacs-Kidney-nan-3m|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLXND1 DST

1.65e-031821524c5d14e33ebdf117b5aa9e2f57aaa89aa51f72bf
ToppCellPND10-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PLXND1 DST

1.67e-031831523427f3cbe6ea81709750e7dd3ff378f03ae65eab
ToppCellfacs-Lung-nan-3m-Endothelial-Artery_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLXND1 DST

1.67e-0318315212e876d6205af8aad74265c668b5e95b9e7487f3
ToppCell3'-GW_trimst-1-SmallIntestine-Epithelial-neuro-epithelial-K_cells_(GIP+)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ADGRG4 ADGRA1

1.67e-03183152d23018193b9c0806e0d1a9ac15e6392eb8e96aaf
ToppCellIPF-Lymphoid-ILC_B|Lymphoid / Disease state, Lineage and Cell class

ADGRA1 DST

1.67e-031831529b507547e6adf78e46e7f542cd9958224ec5826a
ToppCellBasal|World / shred by cell class for mouse tongue

DST PLEC

1.67e-03183152c6729a207526ff4aa48176207b9353176f631fea
ToppCelldroplet-Lung-nan-3m-Mesenchymal-adventitial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADGRA1 ADAMTSL2

1.67e-03183152ddc45fb591ba0ce3fa05c08051d58286a89ef835
ToppCellPND14-Endothelial-Endothelial_blood-vessel-Macrovascular_EC|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PLXND1 DST

1.67e-03183152fc9a7ba148c22d0c8a46f6bc56c772929ac496f7
ToppCelldroplet-Lung-nan-3m-Mesenchymal-Adventitial_Fibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADGRA1 ADAMTSL2

1.67e-03183152a253ad65673fce6cb453e709cb235ce7cbfa18b7
ToppCellP28-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_artery|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

PLXND1 DST

1.69e-031841528ed22b1af04a711203293e7a8b3df6fb9222fad5
ToppCell21-Trachea-Mesenchymal-Airway_Smooth_Muscle|Trachea / Age, Tissue, Lineage and Cell class

ADAMTSL2 B3GALT5-AS1

1.69e-0318415286a96cd88e50eacad1f0badfbbf6dc626f41725e
ToppCell10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_hypoxia/MES-A|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

PLXND1 PLEC

1.69e-03184152a902109b04a94770f5f6db5ddc372049f2921d38
ToppCell3'-GW_trimst-1.5-SmallIntestine-Epithelial-neuro-epithelial-EECs|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SI PLXNB1

1.70e-03185152d42f6722a6771752cd744146a09e2ead9b7252bc
ToppCell10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_anti-infl-A|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

PLXND1 PLEC

1.70e-031851520acd8717ffbfb219664452a0947427eaa8b2a62a
ToppCell3'-GW_trimst-2-SmallIntestine-Epithelial-neuro-epithelial-EC_cells_(TAC1+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ADGRG4 ADGRA1

1.70e-03185152eb78614c4acf8d2ce7874d7e51e16997b76127ef
ToppCellCOVID_vent-Myeloid-Dendritic|COVID_vent / Disease condition, Lineage, Cell class and subclass

SI DST

1.72e-0318615263a5cdd3f60681762a218be32db84be8f29b88fd
ToppCellCOVID_vent-Myeloid-Dendritic-cDC|COVID_vent / Disease condition, Lineage, Cell class and subclass

SI DST

1.72e-0318615239457a7b43537f2c3e221f9375c95d4515424d7d
ToppCell343B-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0.5|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)

RNF220 PLEC

1.72e-03186152bbb8edea8d8bdc1a469faec1563e40b1f62d7f3d
ToppCellE16.5-samps-Mesenchymal-Myofibroblast|E16.5-samps / Age Group, Lineage, Cell class and subclass

ADAMTSL2 DST

1.72e-03186152e044b3428b7eacfdc72d0f57cdabaa1de04c74cd
ToppCellfacs-Lung-ENDOMUCIN-18m-Endothelial-Artery_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLXND1 DST

1.72e-031861525302399825f213d105ac70b91366a4513b732838
ToppCellPrimary_Visual_cortex_(V1C)-Non-neuronal-Macroglial|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RNF220 PLXNB1

1.74e-0318715297e520705491c8f52a32025311a9fa7b9176979a
ToppCellP03-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_artery|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

PLXND1 DST

1.74e-0318715266ebe1788d51b3e17bec6cdb219f709756b4e530
ToppCellfacs-Lung-3m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l25|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PLXND1 DST

1.74e-031871527170694a1b86fe8d84d96c880ffe57af09bdc026
ToppCellControl-Fibroblasts-Alveolar_FB|Control / group, cell type (main and fine annotations)

ADAMTSL2 DST

1.74e-0318715292d468dde81125d51daf7abd4703741abe1ab91c
ToppCellnormal_Lymph_Node-Myeloid_cells-mo-Mac|normal_Lymph_Node / Location, Cell class and cell subclass

B3GALT5-AS1 DST

1.76e-03188152e83de94a9b47a6a90e98face887eae031a322af6
ToppCellSomatosensory_Cortex_(S1)-Non-neuronal-Macroglial-Oligo|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RNF220 PLXNB1

1.76e-0318815260242c29c7f16c94a84685d3bc4ed93a66e70152
ToppCell5'-Adult-Appendix-Endothelial-blood_vessel_EC-arterial_capillary|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ADAMTSL2 PLXND1

1.76e-03188152a11b12f1857953bcdbfb5f25e127f2350c39567d
ToppCellP15-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_artery|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

PLXND1 DST

1.76e-0318815250b27fc12347ca16bd62333baf345c83cb422a8f
ToppCellP28-Endothelial-large_vessel_endothelial_cell|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

PLXND1 DST

1.76e-03188152263169029293e005bcffd87db20221fdd2d3917e
ToppCellMid-temporal_gyrus_(MTG)-Non-neuronal-Macroglial|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RNF220 PLXNB1

1.76e-03188152505b6b4277d7dea87aee27191d0acca67928b8e6
ToppCellE16.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PLXND1 PLEC

1.78e-03189152feedac2751ed770f80bc56fec31662b5b3826f58
ToppCellSomatosensory_Cortex_(S1)-Non-neuronal|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RNF220 PLXNB1

1.78e-0318915242ab4cc5fbf8580841f31889446fe4499df1a464
ToppCellprimary_auditory_cortex_(A1C)-Non-neuronal-Macroglial|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RNF220 PLXNB1

1.78e-03189152784ace2be87f2ecb19490f4974f63a559516e0eb
ToppCellprimary_auditory_cortex_(A1C)-Non-neuronal|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RNF220 PLXNB1

1.78e-0318915237ecbd73408d462b47d7e5611f203143e08a2689
ToppCellPrimary_Motor_Cortex_(M1)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte-Oligo_L4-6_OPALIN|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RNF220 PLXNB1

1.78e-03189152b60c8a29d3169c4830fe63b01db90c57660fc239
ToppCell10x5'-lymph-node_spleen-Lymphocytic_Invariant-Inducer-like|lymph-node_spleen / Manually curated celltypes from each tissue

PLXND1 DST

1.80e-031901520c7eb8f4f2926af01bf44d5c9f239be7b81c67fe
ToppCellSomatosensory_Cortex_(S1)-Non-neuronal-Macroglial|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RNF220 PLXNB1

1.80e-0319015207f21386ea6eb23416a537d2250e3042efe93fb0
Diseaseepidermolysis bullosa simplex (is_implicated_in)

DST PLEC

4.38e-067142DOID:4644 (is_implicated_in)
Diseasefibrinogen measurement, tissue plasminogen activator measurement

PLXND1 PLEC

2.05e-0445142EFO_0004623, EFO_0004791
Diseasedevelopmental disorder of mental health (implicated_via_orthology)

PLXNB1 PLXND1

2.43e-0449142DOID:0060037 (implicated_via_orthology)
Diseaseresting heart rate

RNF220 PLEC

2.21e-03149142EFO_0004351
Diseaseobesity (implicated_via_orthology)

PLXNB1 PLXND1

4.54e-03215142DOID:9970 (implicated_via_orthology)
Diseaseaspartate aminotransferase to alanine aminotransferase ratio

TYW1B PLEC

5.58e-03239142EFO_0010934

Protein segments in the cluster

PeptideGeneStartEntry
CRIHVQAHWGCWQNS

B3GALT5-AS1

81

P59052
ESVREQWQIHLCCGW

ADGRG4

2991

Q8IZF6
QHDTQWCVCELQWCI

ADAM20

351

O43506
HCAKREDVWQCWWAC

ADGRA1

306

Q86SQ6
TCLCWAWQQCSSEQN

IRF1-AS1

96

Q8N8D9
QWSWILQLCQCVEQH

DST

786

Q03001
CWEDHTWRLQSSNCV

FER1L4

531

A9Z1Z3
CNWCVWQHLCTHKAS

PLXNB1

651

O43157
QWPCFWCSQQHSCVS

PLXND1

721

Q9Y4D7
AHWLAQDWERCNTTC

ADAMTSL2

796

Q86TH1
QGTLCEDWLAVHCCW

PLAC8L1

131

A1L4L8
NCIDWWANECSIFHQ

SI

481

P14410
TSIQCWHVHCEECWL

RNF220

526

Q5VTB9
DPQWICAWQTALCQH

TSTD2

181

Q5T7W7
ALQTQWSWMLQLCCC

PLEC

836

Q15149
ACANKCVFCWWHHNN

TYW1B

351

Q6NUM6