Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	cysteine-type deubiquitinase activity	USP17L4 USP17L2 USP17L1 USP17L17 USP17L11 USP17L6P USP17L3 USP17L10 USP17L19 USP17L22 USP17L8 USP17L13 USP17L18	2.23e-17	114	62	13	GO:0004843
GeneOntologyMolecularFunction	deubiquitinase activity	USP17L4 USP17L2 USP17L1 USP17L17 USP17L11 USP17L6P USP17L3 USP17L10 USP17L19 USP17L22 USP17L8 USP17L13 USP17L18	6.89e-17	124	62	13	GO:0101005
GeneOntologyMolecularFunction	ubiquitin-like protein peptidase activity	USP17L4 USP17L2 USP17L1 USP17L17 USP17L11 USP17L6P USP17L3 USP17L10 USP17L19 USP17L22 USP17L8 USP17L13 USP17L18	2.61e-16	137	62	13	GO:0019783
GeneOntologyMolecularFunction	cysteine-type peptidase activity	USP17L4 USP17L2 USP17L1 USP17L17 USP17L11 USP17L6P USP17L3 USP17L10 USP17L19 USP17L22 USP17L8 USP17L13 USP17L18	2.19e-14	192	62	13	GO:0008234
GeneOntologyMolecularFunction	peptidase activity	USP17L4 USP17L2 USP17L1 USP17L17 USP17L11 LPA USP17L6P USP17L3 CORIN USP17L10 USP17L19 PLG USP17L22 USP17L8 USP17L13 USP17L18	9.85e-11	654	62	16	GO:0008233
GeneOntologyMolecularFunction	calcium channel activity	TRPC5 CACNG5 TRPM1 PKD1L3	6.94e-04	129	62	4	GO:0005262
GeneOntologyMolecularFunction	protein antigen binding	LPA PLG	1.11e-03	16	62	2	GO:1990405
GeneOntologyMolecularFunction	calcium ion transmembrane transporter activity	TRPC5 CACNG5 TRPM1 PKD1L3	1.25e-03	151	62	4	GO:0015085
GeneOntologyBiologicalProcess	protein deubiquitination	USP17L4 USP17L2 USP17L1 USP17L17 USP17L11 USP17L6P USP17L3 USP17L10 USP17L19 USP17L22 USP17L8 USP17L13 USP17L18	5.07e-17	125	62	13	GO:0016579
GeneOntologyBiologicalProcess	protein modification by small protein removal	USP17L4 USP17L2 USP17L1 USP17L17 USP17L11 USP17L6P USP17L3 USP17L10 USP17L19 USP17L22 USP17L8 USP17L13 USP17L18	3.34e-16	144	62	13	GO:0070646
GeneOntologyBiologicalProcess	protein modification by small protein conjugation or removal	USP17L4 USP17L2 USP17L1 USP17L17 USP17L11 USP17L6P USP17L3 OS9 USP17L10 USP17L19 ARIH1 USP17L22 DDB1 USP17L8 USP17L13 USP17L18	3.12e-08	1009	62	16	GO:0070647
GeneOntologyBiologicalProcess	post-translational protein modification	USP17L4 USP17L2 USP17L1 USP17L17 USP17L11 USP17L6P USP17L3 OS9 USP17L10 USP17L19 ARIH1 USP17L22 DDB1 USP17L8 USP17L13 USP17L18	7.41e-08	1074	62	16	GO:0043687
GeneOntologyBiologicalProcess	multi-pass transmembrane protein insertion into ER membrane	NOMO2 NOMO3 NOMO1	2.14e-06	9	62	3	GO:0160063
GeneOntologyBiologicalProcess	inner cell mass cell proliferation	BRCA2 BRD4 INTS1	1.71e-05	17	62	3	GO:0001833
GeneOntologyBiologicalProcess	trans-synaptic signaling, modulating synaptic transmission	LPA PLG FAAH	6.40e-05	26	62	3	GO:0099550
GeneOntologyBiologicalProcess	positive regulation of fibrinolysis	LPA PLG	8.84e-05	5	62	2	GO:0051919
GeneOntologyBiologicalProcess	female pregnancy	FBN2 INTS1 CORIN CSMD1 RECK STAT5B	1.02e-04	249	62	6	GO:0007565
GeneOntologyBiologicalProcess	protein insertion into ER membrane	NOMO2 NOMO3 NOMO1	1.09e-04	31	62	3	GO:0045048
GeneOntologyBiologicalProcess	blastocyst growth	BRCA2 BRD4 INTS1	1.32e-04	33	62	3	GO:0001832
GeneOntologyBiologicalProcess	trans-synaptic signaling by BDNF, modulating synaptic transmission	LPA PLG	1.85e-04	7	62	2	GO:0099183
GeneOntologyBiologicalProcess	negative regulation of nodal signaling pathway	NOMO3 NOMO1	1.85e-04	7	62	2	GO:1900108
GeneOntologyBiologicalProcess	multi-organism reproductive process	FBN2 INTS1 CORIN CSMD1 RECK STAT5B	2.33e-04	290	62	6	GO:0044703
GeneOntologyBiologicalProcess	trans-synaptic signaling by BDNF	LPA PLG	2.46e-04	8	62	2	GO:0099191
GeneOntologyBiologicalProcess	multi-multicellular organism process	FBN2 INTS1 CORIN CSMD1 RECK STAT5B	2.51e-04	294	62	6	GO:0044706
GeneOntologyBiologicalProcess	endoplasmic reticulum organization	NOMO2 RTN4 NOMO3 NOMO1	3.03e-04	107	62	4	GO:0007029
GeneOntologyBiologicalProcess	regulation of nodal signaling pathway	NOMO3 NOMO1	3.16e-04	9	62	2	GO:1900107
GeneOntologyBiologicalProcess	determination of left/right asymmetry in lateral mesoderm	NOMO3 NOMO1	3.94e-04	10	62	2	GO:0003140
GeneOntologyBiologicalProcess	protein insertion into membrane	NOMO2 NOMO3 NOMO1	4.58e-04	50	62	3	GO:0051205
GeneOntologyCellularComponent	endoplasmic reticulum membrane	FZD9 USP17L4 USP17L2 USP17L1 USP17L17 NOMO2 USP17L11 RTN4 USP17L6P USP17L3 OS9 USP17L10 TRPM1 USP17L19 USP17L22 NOMO3 FAAH USP17L8 USP17L13 NOMO1 USP17L18	5.66e-11	1293	62	21	GO:0005789
GeneOntologyCellularComponent	endoplasmic reticulum subcompartment	FZD9 USP17L4 USP17L2 USP17L1 USP17L17 NOMO2 USP17L11 RTN4 USP17L6P USP17L3 OS9 USP17L10 TRPM1 USP17L19 USP17L22 NOMO3 FAAH USP17L8 USP17L13 NOMO1 USP17L18	6.17e-11	1299	62	21	GO:0098827
GeneOntologyCellularComponent	nuclear outer membrane-endoplasmic reticulum membrane network	FZD9 USP17L4 USP17L2 USP17L1 USP17L17 NOMO2 USP17L11 RTN4 USP17L6P USP17L3 OS9 USP17L10 TRPM1 USP17L19 USP17L22 NOMO3 FAAH USP17L8 USP17L13 NOMO1 USP17L18	9.16e-11	1327	62	21	GO:0042175
GeneOntologyCellularComponent	multi-pass translocon complex	NOMO2 NOMO3 NOMO1	2.06e-06	9	62	3	GO:0160064
GeneOntologyCellularComponent	ER membrane insertion complex	NOMO2 NOMO3 NOMO1	8.84e-06	14	62	3	GO:0072379
GeneOntologyCellularComponent	nuclear ubiquitin ligase complex	BRCA2 BUB1B PCGF5	4.15e-04	49	62	3	GO:0000152
GeneOntologyCellularComponent	ubiquitin ligase complex	BRCA2 BUB1B OS9 ARIH1 DDB1 PCGF5	6.07e-04	352	62	6	GO:0000151
GeneOntologyCellularComponent	Cul4A-RING E3 ubiquitin ligase complex	ARIH1 DDB1	7.70e-04	14	62	2	GO:0031464
HumanPheno	Abnormal duodenum morphology	FBN2 BRCA2 RTTN BUB1B PLG	7.21e-06	88	17	5	HP:0002246
MousePheno	increased thymus weight	USP17L2 BRCA2 MC2R USP17L13	7.89e-07	24	43	4	MP:0004955
MousePheno	abnormal mammary gland connective tissue morphology	LPA PLG	9.24e-06	2	43	2	MP:0009507
MousePheno	esophageal ulcer	LPA PLG	9.24e-06	2	43	2	MP:0004547
MousePheno	duodenal ulcer	LPA PLG	9.24e-06	2	43	2	MP:0003273
MousePheno	perianal ulcer	LPA PLG	9.24e-06	2	43	2	MP:0005035
MousePheno	ectropion	LPA PLG	9.24e-06	2	43	2	MP:0006164
MousePheno	absent cornea epithelium	LPA PLG	2.77e-05	3	43	2	MP:0020856
MousePheno	abnormal thymus weight	USP17L2 BRCA2 MC2R USP17L13	3.34e-05	60	43	4	MP:0004954
MousePheno	increased circulating fibrinogen level	LPA PLG	5.52e-05	4	43	2	MP:0012331
MousePheno	proctitis	LPA PLG	5.52e-05	4	43	2	MP:0003305
MousePheno	decreased neuron apoptosis	LPA TRPC5 PLG NDRG2	7.24e-05	73	43	4	MP:0003204
MousePheno	gastric ulcer	LPA PLG	1.38e-04	6	43	2	MP:0003282
MousePheno	increased acute phase protein level	LPA PLG	1.92e-04	7	43	2	MP:0014499
MousePheno	abnormal conjunctival epithelium morphology	LPA PLG	1.92e-04	7	43	2	MP:0004481
MousePheno	abnormal brown fat lipid droplet number	MC2R C2CD5	1.92e-04	7	43	2	MP:0009134
MousePheno	venoocclusion	LPA PLG	1.92e-04	7	43	2	MP:0006137
MousePheno	peptic ulcer	LPA PLG	1.92e-04	7	43	2	MP:0003301
MousePheno	decreased susceptibility to neuronal excitotoxicity	LPA TRPC5 PLG	1.96e-04	37	43	3	MP:0008236
MousePheno	enlarged thymus	SPINK13 USP17L2 BRCA2 MC2R DDB1 USP17L13	2.51e-04	292	43	6	MP:0000709
MousePheno	increased trophectoderm apoptosis	USP17L2 USP17L13	2.56e-04	8	43	2	MP:0012119
MousePheno	decreased keratinocyte migration	LPA PLG	2.56e-04	8	43	2	MP:0012194
MousePheno	abnormal circulating fibrinogen level	LPA PLG	2.56e-04	8	43	2	MP:0010213
MousePheno	abnormal thymus morphology	SPINK13 FZD9 USP17L2 BRCA2 MC2R NDRG2 DDB1 STAT5B USP17L13	2.73e-04	717	43	9	MP:0000703
MousePheno	impaired wound healing	LPA BUB1B PLG	2.86e-04	42	43	3	MP:0001792
MousePheno	decreased susceptibility to induced choroidal neovascularization	LPA PLG	4.09e-04	10	43	2	MP:0003434
MousePheno	decreased circulating adrenaline level	MC2R C2CD5	4.09e-04	10	43	2	MP:0005661
MousePheno	abnormal kidney thrombosis	LPA PLG	4.09e-04	10	43	2	MP:0011507
MousePheno	enlarged urinary bladder	UBTF RTTN ARIH1 DDB1	4.33e-04	116	43	4	MP:0011874
MousePheno	cornea vascularization	FBN2 LPA PLG	4.53e-04	49	43	3	MP:0005542
MousePheno	abnormal keratinocyte migration	LPA PLG	4.99e-04	11	43	2	MP:0012192
MousePheno	abnormal vagina morphology	LPA PLG EPHA1	5.09e-04	51	43	3	MP:0001139
MousePheno	decreased apoptosis	LPA TRPC5 LY96 PLG NDRG2	5.34e-04	219	43	5	MP:0006043
MousePheno	abnormal apoptosis	SCML2 FBN2 USP17L2 BRCA2 LPA TRPC5 BUB1B LY96 PLG NDRG2 HSF5 USP17L13	5.74e-04	1353	43	12	MP:0001648
MousePheno	decreased cell death	LPA TRPC5 LY96 PLG NDRG2	5.80e-04	223	43	5	MP:0012555
MousePheno	abnormal mammary gland development	BRCA2 LPA PLG STAT5B	5.92e-04	126	43	4	MP:0000628
MousePheno	increased uterus weight	NR5A2 EPHA1	5.98e-04	12	43	2	MP:0004904
MousePheno	abnormal programmed cell death	SCML2 FBN2 USP17L2 BRCA2 LPA TRPC5 BUB1B LY96 PLG NDRG2 HSF5 USP17L13	6.01e-04	1360	43	12	MP:0014355
MousePheno	abnormal anus morphology	LPA PLG	7.06e-04	13	43	2	MP:0005034
MousePheno	abnormal conjunctiva morphology	LPA PLG	7.06e-04	13	43	2	MP:0001310
MousePheno	embryonic lethality prior to organogenesis	DHX15 USP17L2 BRCA2 UBTF BRD4 INTS1 BUB1B NR5A2 ARIH1 DDB1 USP17L13	8.06e-04	1204	43	11	MP:0013292
MousePheno	increased total tissue mass	USP17L2 CORIN CSMD1 C2CD5 STAT5B USP17L13	8.08e-04	364	43	6	MP:0012323
MousePheno	increased body weight	USP17L2 CORIN CSMD1 C2CD5 STAT5B USP17L13	8.08e-04	364	43	6	MP:0001260
MousePheno	decreased adrenaline level	MC2R C2CD5	9.46e-04	15	43	2	MP:0030762
MousePheno	abnormal microglial cell physiology	LPA PLG NDRG2	9.47e-04	63	43	3	MP:0003691
MousePheno	abnormal female reproductive system physiology	BRCA2 LPA TRPC5 BUB1B NR5A2 PLG AKAP1 EPHA1 STAT5B	1.17e-03	876	43	9	MP:0003699
MousePheno	abnormal colon morphology	LPA BUB1B NR5A2 PLG	1.19e-03	152	43	4	MP:0000495
MousePheno	increased hepatocyte proliferation	LPA PLG	1.22e-03	17	43	2	MP:0003893
MousePheno	lactation failure	LPA PLG	1.22e-03	17	43	2	MP:0010249
MousePheno	abnormal lactation	LPA PLG STAT5B	1.39e-03	72	43	3	MP:0001882
MousePheno	abnormal cell proliferation	FZD9 USP17L2 BRCA2 LPA BUB1B ACTN2 LY96 PLG NDRG2 STAT5B USP17L13	1.46e-03	1294	43	11	MP:0000350
MousePheno	increased body size	USP17L2 CORIN CSMD1 C2CD5 STAT5B USP17L13	1.47e-03	409	43	6	MP:0001264
MousePheno	abnormal thymus size	SPINK13 FZD9 USP17L2 BRCA2 MC2R DDB1 USP17L13	1.53e-03	564	43	7	MP:0002364
MousePheno	choroidal neovascularization	LPA PLG	1.53e-03	19	43	2	MP:0005546
MousePheno	abnormal circulating adrenaline level	MC2R C2CD5	1.87e-03	21	43	2	MP:0005660
MousePheno	abnormal endocrine gland morphology	SPINK13 FZD9 USP17L2 BRCA2 UBTF MC2R NDRG2 DDB1 STAT5B USP17L13	2.04e-03	1144	43	10	MP:0013560
MousePheno	reduced female fertility	LPA TRPC5 NR5A2 PLG AKAP1	2.05e-03	296	43	5	MP:0001923
MousePheno	abnormal skin adnexa development	BRCA2 LPA PLG STAT5B	2.09e-03	177	43	4	MP:0020982
MousePheno	embryonic lethality prior to organogenesis, complete penetrance	DHX15 USP17L2 BRCA2 UBTF INTS1 BUB1B NR5A2 USP17L13	2.16e-03	772	43	8	MP:0014259
MousePheno	embryonic lethality prior to tooth bud stage, complete penetrance	DHX15 USP17L2 BRCA2 UBTF INTS1 BUB1B NR5A2 USP17L13	2.29e-03	779	43	8	MP:0014257
MousePheno	abnormal proamniotic cavity morphology	BRCA2 NR5A2	2.44e-03	24	43	2	MP:0011197
MousePheno	abnormal involution of the mammary gland	LPA PLG	2.44e-03	24	43	2	MP:0006271
MousePheno	intestinal ulcer	LPA PLG	2.44e-03	24	43	2	MP:0000512
MousePheno	abnormal mammary gland physiology	LPA PLG STAT5B	2.48e-03	88	43	3	MP:0001881
MousePheno	abnormal apocrine gland physiology	LPA PLG STAT5B	2.48e-03	88	43	3	MP:0013555
MousePheno	embryonic lethality prior to tooth bud stage	DHX15 USP17L2 BRCA2 UBTF BRD4 INTS1 BUB1B NR5A2 ARIH1 DDB1 USP17L13	2.50e-03	1383	43	11	MP:0013293
Domain	UCH	USP17L4 USP17L2 USP17L1 USP17L17 USP17L11 USP17L3 USP17L10 USP17L19 USP17L22 USP17L8 USP17L13 USP17L18	4.15e-18	71	60	12	PF00443
Domain	USP_2	USP17L4 USP17L2 USP17L1 USP17L17 USP17L11 USP17L3 USP17L10 USP17L19 USP17L22 USP17L8 USP17L13 USP17L18	4.15e-18	71	60	12	PS00973
Domain	USP_3	USP17L4 USP17L2 USP17L1 USP17L17 USP17L11 USP17L3 USP17L10 USP17L19 USP17L22 USP17L8 USP17L13 USP17L18	4.97e-18	72	60	12	PS50235
Domain	USP_dom	USP17L4 USP17L2 USP17L1 USP17L17 USP17L11 USP17L3 USP17L10 USP17L19 USP17L22 USP17L8 USP17L13 USP17L18	4.97e-18	72	60	12	IPR028889
Domain	Peptidase_C19_UCH	USP17L4 USP17L2 USP17L1 USP17L17 USP17L11 USP17L3 USP17L10 USP17L19 USP17L22 USP17L8 USP17L13 USP17L18	4.97e-18	72	60	12	IPR001394
Domain	HABP4_PAI-RBP1	USP17L2 USP17L17 USP17L11 USP17L3 USP17L19 USP17L22 USP17L13 USP17L18	8.80e-17	16	60	8	PF04774
Domain	HABP4_PAIRBP1-bd	USP17L2 USP17L17 USP17L11 USP17L3 USP17L19 USP17L22 USP17L13 USP17L18	8.80e-17	16	60	8	IPR006861
Domain	USP_CS	USP17L2 USP17L1 USP17L17 USP17L11 USP17L3 USP17L10 USP17L19 USP17L22 USP17L8 USP17L13 USP17L18	1.34e-16	66	60	11	IPR018200
Domain	USP_1	USP17L4 USP17L2 USP17L17 USP17L11 USP17L3 USP17L10 USP17L19 USP17L22 USP17L8 USP17L13 USP17L18	2.67e-16	70	60	11	PS00972
Domain	DUF2012	NOMO2 NOMO3 NOMO1	1.26e-07	4	60	3	PF09430
Domain	DUF2012	NOMO2 NOMO3 NOMO1	1.26e-07	4	60	3	IPR019008
Domain	Carb-bd-like_fold	NOMO2 NOMO3 NOMO1	1.74e-06	8	60	3	IPR013784
Domain	CarboxyPept_regulatory_dom	NOMO2 NOMO3 NOMO1	8.81e-06	13	60	3	IPR014766
Domain	-	NOMO2 NOMO3 NOMO1	8.81e-06	13	60	3	2.60.40.1120
Domain	CarboxyPept-like_regulatory	NOMO2 NOMO3 NOMO1	2.08e-05	17	60	3	IPR008969
Domain	Kringle-like	LPA LY96 PLG	1.46e-04	32	60	3	IPR013806
Domain	Kringle	LPA PLG	1.34e-03	17	60	2	IPR000001
Domain	Kringle_CS	LPA PLG	1.34e-03	17	60	2	IPR018056
Domain	KRINGLE_2	LPA PLG	1.34e-03	17	60	2	PS50070
Domain	Kringle	LPA PLG	1.34e-03	17	60	2	PF00051
Domain	KRINGLE_1	LPA PLG	1.34e-03	17	60	2	PS00021
Domain	KR	LPA PLG	1.34e-03	17	60	2	SM00130
Domain	FRI	FZD9 CORIN	1.86e-03	20	60	2	SM00063
Domain	-	FZD9 CORIN	2.05e-03	21	60	2	1.10.2000.10
Domain	Frizzled_dom	FZD9 CORIN	2.68e-03	24	60	2	IPR020067
Domain	FZ	FZD9 CORIN	2.68e-03	24	60	2	PS50038
Domain	Fz	FZD9 CORIN	2.68e-03	24	60	2	PF01392
Domain	TRYPSIN_HIS	LPA CORIN PLG	4.44e-03	103	60	3	IPR018114
Domain	TRYPSIN_SER	LPA CORIN PLG	4.81e-03	106	60	3	PS00135
Domain	TRYPSIN_HIS	LPA CORIN PLG	4.94e-03	107	60	3	PS00134
Domain	Peptidase_S1A	LPA CORIN PLG	5.74e-03	113	60	3	IPR001314
Domain	TRYPSIN_DOM	LPA CORIN PLG	6.03e-03	115	60	3	PS50240
Domain	Tryp_SPc	LPA CORIN PLG	6.32e-03	117	60	3	SM00020
Domain	Trypsin	LPA CORIN PLG	6.94e-03	121	60	3	PF00089
Domain	Trypsin_dom	LPA CORIN PLG	6.94e-03	121	60	3	IPR001254
Domain	Peptidase_S1_PA	LPA CORIN PLG	7.26e-03	123	60	3	IPR009003
Domain	KAZAL	SPINK13 RECK	9.59e-03	46	60	2	SM00280
Domain	KAZAL_2	SPINK13 RECK	1.13e-02	50	60	2	PS51465
Pathway	REACTOME_RAS_PROCESSING	USP17L4 USP17L2 USP17L1 USP17L17 USP17L11 USP17L6P USP17L3 USP17L10 USP17L19 USP17L22 USP17L8 USP17L13 USP17L18	4.07e-22	45	53	13	MM15671
Pathway	REACTOME_UB_SPECIFIC_PROCESSING_PROTEASES	USP17L4 USP17L2 USP17L1 USP17L17 USP17L11 USP17L6P USP17L3 USP17L10 USP17L19 USP17L22 USP17L8 USP17L13 USP17L18	1.80e-13	191	53	13	MM15289
Pathway	REACTOME_MAPK_FAMILY_SIGNALING_CASCADES	USP17L4 USP17L2 USP17L1 USP17L17 USP17L11 USP17L6P USP17L3 USP17L10 USP17L19 ACTN2 USP17L22 USP17L8 USP17L13 USP17L18	7.23e-12	318	53	14	MM15278
Pathway	REACTOME_DEUBIQUITINATION	USP17L4 USP17L2 USP17L1 USP17L17 USP17L11 USP17L6P USP17L3 USP17L10 USP17L19 USP17L22 USP17L8 USP17L13 USP17L18	1.02e-11	262	53	13	MM15286
Pathway	REACTOME_UB_SPECIFIC_PROCESSING_PROTEASES	USP17L4 USP17L2 USP17L1 USP17L17 USP17L11 USP17L3 USP17L10 USP17L19 USP17L22 USP17L8 USP17L13 USP17L18	2.48e-11	221	53	12	M27578
Pathway	REACTOME_DEUBIQUITINATION	USP17L4 USP17L2 USP17L1 USP17L17 USP17L11 USP17L3 USP17L10 USP17L19 USP17L22 USP17L8 USP17L13 USP17L18	8.16e-10	299	53	12	M27574
Pathway	REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION	USP17L4 USP17L2 USP17L1 USP17L17 USP17L11 NR5A2 USP17L6P USP17L3 USP17L10 USP17L19 USP17L22 DDB1 RECK USP17L8 USP17L13 USP17L18	3.15e-05	1389	53	16	MM15307
Pathway	REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION	USP17L4 USP17L2 USP17L1 USP17L17 USP17L11 NR5A2 USP17L3 OS9 USP17L10 USP17L19 USP17L22 DDB1 RECK USP17L8 USP17L13 USP17L18	6.56e-05	1475	53	16	M19806
Pubmed	DUB-1, a deubiquitinating enzyme with growth-suppressing activity.	USP17L4 USP17L2 USP17L1 USP17L17 USP17L11 USP17L6P USP17L3 USP17L10 USP17L19 USP17L22 USP17L8 USP17L13 USP17L18	9.59e-32	21	62	13	8622927
Pubmed	DUB-1A, a novel deubiquitinating enzyme subfamily member, is polyubiquitinated and cytokine-inducible in B-lymphocytes.	USP17L4 USP17L2 USP17L1 USP17L17 USP17L11 USP17L6P USP17L3 USP17L10 USP17L19 USP17L22 USP17L8 USP17L13 USP17L18	9.59e-32	21	62	13	14583620
Pubmed	DUB-2A, a new member of the DUB subfamily of hematopoietic deubiquitinating enzymes.	USP17L4 USP17L2 USP17L1 USP17L17 USP17L11 USP17L6P USP17L3 USP17L10 USP17L19 USP17L22 USP17L8 USP17L13 USP17L18	9.59e-32	21	62	13	11468161
Pubmed	The murine DUB-1 gene is specifically induced by the betac subunit of interleukin-3 receptor.	USP17L4 USP17L2 USP17L1 USP17L17 USP17L11 USP17L6P USP17L3 USP17L10 USP17L19 USP17L22 USP17L8 USP17L13 USP17L18	9.59e-32	21	62	13	8756639
Pubmed	Lymphocyte-specific murine deubiquitinating enzymes induced by cytokines.	USP17L4 USP17L2 USP17L1 USP17L17 USP17L11 USP17L6P USP17L3 USP17L10 USP17L19 USP17L22 USP17L8 USP17L13 USP17L18	9.59e-32	21	62	13	12447969
Pubmed	DUB-1, a fate determinant of dynein heavy chain in B-lymphocytes, is regulated by the ubiquitin-proteasome pathway.	USP17L4 USP17L2 USP17L1 USP17L17 USP17L11 USP17L6P USP17L3 USP17L10 USP17L19 USP17L22 USP17L8 USP17L13 USP17L18	9.59e-32	21	62	13	18980247
Pubmed	JAK2 is required for induction of the murine DUB-1 gene.	USP17L4 USP17L2 USP17L1 USP17L17 USP17L11 USP17L6P USP17L3 USP17L10 USP17L19 USP17L22 USP17L8 USP17L13 USP17L18	2.34e-31	22	62	13	9154835
Pubmed	DUB-2 is a member of a novel family of cytokine-inducible deubiquitinating enzymes.	USP17L4 USP17L2 USP17L1 USP17L17 USP17L11 USP17L6P USP17L3 USP17L10 USP17L19 USP17L22 USP17L8 USP17L13 USP17L18	1.17e-30	24	62	13	8995226
Pubmed	Interleukin 1 receptor signaling regulates DUBA expression and facilitates Toll-like receptor 9-driven antiinflammatory cytokine production.	USP17L4 USP17L2 USP17L1 USP17L17 USP17L11 USP17L6P USP17L3 USP17L10 USP17L19 USP17L22 USP17L8 USP17L13 USP17L18	2.44e-30	25	62	13	21115691
Pubmed	Decabromodiphenyl ethane affects embryonic development by interfering with nuclear F-actin in zygotes and leads to cognitive and social disorders in offspring mice.	USP17L4 USP17L2 USP17L1 USP17L17 USP17L11 USP17L6P USP17L3 USP17L10 USP17L19 USP17L22 USP17L8 USP17L13 USP17L18	4.87e-30	26	62	13	35816173
Pubmed	Minor Splicing Factors Zrsr1 and Zrsr2 Are Essential for Early Embryo Development and 2-Cell-Like Conversion.	USP17L4 USP17L2 USP17L1 USP17L17 USP17L11 USP17L6P USP17L3 USP17L10 USP17L19 USP17L22 USP17L8 USP17L13 USP17L18	3.16e-29	29	62	13	32527007
Pubmed	Cdc25A and Dub3 in a high-stakes balancing act.	USP17L4 USP17L2 USP17L1 USP17L17 USP17L11 USP17L6P USP17L3 USP17L10 USP17L19 USP17L22 USP17L8 USP17L13 USP17L18	2.66e-28	33	62	13	20228807
Pubmed	The DUB/USP17 deubiquitinating enzymes: a gene family within a tandemly repeated sequence, is also embedded within the copy number variable beta-defensin cluster.	USP17L4 USP17L2 USP17L1 USP17L17 USP17L11 USP17L6P USP17L3 USP17L10 USP17L19 USP17L22 USP17L8 USP17L13 USP17L18	4.30e-28	34	62	13	20403174
Pubmed	Hyaluronan- and RNA-binding deubiquitinating enzymes of USP17 family members associated with cell viability.	USP17L4 USP17L2 USP17L1 USP17L17 USP17L11 USP17L6P USP17L3 USP17L10 USP17L19 USP17L22 USP17L8 USP17L13 USP17L18	4.30e-28	34	62	13	17109758
Pubmed	The deubiquitinating enzyme USP17 is highly expressed in tumor biopsies, is cell cycle regulated, and is required for G1-S progression.	USP17L4 USP17L2 USP17L1 USP17L17 USP17L11 USP17L6P USP17L3 USP17L10 USP17L19 USP17L22 USP17L8 USP17L13 USP17L18	4.30e-28	34	62	13	20388806
Pubmed	DUB-3, a cytokine-inducible deubiquitinating enzyme that blocks proliferation.	USP17L4 USP17L2 USP17L1 USP17L17 USP17L11 USP17L6P USP17L3 USP17L10 USP17L19 USP17L22 USP17L8 USP17L13 USP17L18	4.30e-28	34	62	13	14699124
Pubmed	Polyclonal and monoclonal antibodies specific for USP17, a proapoptotic deubiquitinating enzyme.	USP17L4 USP17L2 USP17L1 USP17L17 USP17L11 USP17L6P USP17L3 USP17L10 USP17L19 USP17L22 USP17L8 USP17L13 USP17L18	4.30e-28	34	62	13	20715989
Pubmed	Human megasatellite DNA RS447: copy-number polymorphisms and interspecies conservation.	USP17L4 USP17L2 USP17L1 USP17L17 USP17L11 USP17L6P USP17L3 USP17L10 USP17L19 USP17L22 USP17L8 USP17L13 USP17L18	4.30e-28	34	62	13	9806828
Pubmed	The ubiquitin-specific protease 17 is involved in virus-triggered type I IFN signaling.	USP17L4 USP17L2 USP17L1 USP17L17 USP17L11 USP17L6P USP17L3 USP17L10 USP17L19 USP17L22 USP17L8 USP17L13 USP17L18	4.30e-28	34	62	13	20368735
Pubmed	The DUB/USP17 deubiquitinating enzymes, a multigene family within a tandemly repeated sequence.	USP17L4 USP17L2 USP17L1 USP17L17 USP17L11 USP17L6P USP17L3 USP17L10 USP17L19 USP17L22 USP17L8 USP17L13 USP17L18	4.30e-28	34	62	13	15780755
Pubmed	USP17 regulates Ras activation and cell proliferation by blocking RCE1 activity.	USP17L4 USP17L2 USP17L1 USP17L17 USP17L11 USP17L6P USP17L3 USP17L10 USP17L19 USP17L22 USP17L8 USP17L13 USP17L18	4.30e-28	34	62	13	19188362
Pubmed	Unstable transmission of the RS447 human megasatellite tandem repetitive sequence that contains the USP17 deubiquitinating enzyme gene.	USP17L4 USP17L2 USP17L1 USP17L17 USP17L11 USP17L6P USP17L3 USP17L10 USP17L19 USP17L22 USP17L8 USP17L13 USP17L18	4.30e-28	34	62	13	11941478
Pubmed	The RS447 human megasatellite tandem repetitive sequence encodes a novel deubiquitinating enzyme with a functional promoter.	USP17L4 USP17L2 USP17L1 USP17L17 USP17L11 USP17L6P USP17L3 USP17L10 USP17L19 USP17L22 USP17L8 USP17L13 USP17L18	4.30e-28	34	62	13	10936051
Pubmed	The deubiquitinating enzyme USP17 is essential for GTPase subcellular localization and cell motility.	USP17L4 USP17L2 USP17L1 USP17L17 USP17L11 USP17L6P USP17L3 USP17L10 USP17L19 USP17L22 USP17L8 USP17L13 USP17L18	4.30e-28	34	62	13	21448158
Pubmed	Cytokine-regulated protein degradation by the ubiquitination system.	USP17L4 USP17L2 USP17L1 USP17L17 USP17L11 USP17L6P USP17L3 USP17L10 USP17L19 USP17L22 USP17L8 USP17L13 USP17L18	6.83e-28	35	62	13	16611142
Pubmed	Lys-63-specific deubiquitination of SDS3 by USP17 regulates HDAC activity.	USP17L4 USP17L2 USP17L1 USP17L17 USP17L11 USP17L6P USP17L3 USP17L10 USP17L19 USP17L22 USP17L8 USP17L13 USP17L18	6.83e-28	35	62	13	21239494
Pubmed	The deubiquitinating enzyme USP17 blocks N-Ras membrane trafficking and activation but leaves K-Ras unaffected.	USP17L4 USP17L2 USP17L1 USP17L17 USP17L11 USP17L6P USP17L3 USP17L10 USP17L19 USP17L22 USP17L8 USP17L13 USP17L18	1.07e-27	36	62	13	20147298
Pubmed	Ubiquitin hydrolase Dub3 promotes oncogenic transformation by stabilizing Cdc25A.	USP17L4 USP17L2 USP17L1 USP17L17 USP17L11 USP17L6P USP17L3 USP17L10 USP17L19 USP17L22 USP17L8 USP17L13 USP17L18	1.64e-27	37	62	13	20228808
Pubmed	DUX is a non-essential synchronizer of zygotic genome activation.	USP17L4 USP17L2 USP17L1 USP17L17 USP17L11 USP17L6P USP17L3 USP17L10 USP17L19 USP17L22 USP17L8 USP17L13 USP17L18	1.61e-25	50	62	13	31806660
Pubmed	USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities.	SHROOM4 USP17L4 SCML2 FBN2 USP17L2 USP17L1 USP17L17 USP17L11 USP17L6P USP17L3 USP17L10 TRPM1 USP17L19 USP17L22 PCGF5 USP17L8 USP17L13 USP17L18	9.93e-17	674	62	18	37196079
Pubmed	High Dub3 expression in mouse ESCs couples the G1/S checkpoint to pluripotency.	USP17L4 USP17L2 USP17L1 USP17L6P USP17L3 USP17L8	5.23e-15	10	62	6	24207026
Pubmed	Cell cycle-dependent expression of Dub3, Nanog and the p160 family of nuclear receptor coactivators (NCoAs) in mouse embryonic stem cells.	USP17L4 USP17L2 USP17L1 USP17L6P USP17L3 USP17L8	2.29e-14	12	62	6	24695638
Pubmed	ES cell neural differentiation reveals a substantial number of novel ESTs.	USP17L4 USP17L2 USP17L1 USP17L6P USP17L3 USP17L8	7.43e-14	14	62	6	11793228
Pubmed	CDK4/6-dependent activation of DUB3 regulates cancer metastasis through SNAIL1.	USP17L4 USP17L2 USP17L1 USP17L6P USP17L3 USP17L8	6.67e-13	19	62	6	28067227
Pubmed	DNA sequence and analysis of human chromosome 8.	USP17L4 USP17L1 INTS1 USP17L3 CSMD1 USP17L8	2.90e-10	48	62	6	16421571
Pubmed	Recurrent NOMO1 Gene Deletion Is a Potential Clinical Marker in Early-Onset Colorectal Cancer and Is Involved in the Regulation of Cell Migration.	NOMO2 NOMO3 NOMO1	5.39e-09	3	62	3	36011023
Pubmed	Silencing of nodal modulator 1 inhibits the differentiation of P19 cells into cardiomyocytes.	NOMO2 NOMO3 NOMO1	5.39e-09	3	62	3	25576386
Pubmed	Human and mouse proteases: a comparative genomic approach.	USP17L4 USP17L2 USP17L1 USP17L6P USP17L3 USP17L8	7.32e-09	81	62	6	12838346
Pubmed	Establishment of a conditional Nomo1 mouse model by CRISPR/Cas9 technology.	NOMO2 NOMO3 NOMO1	2.16e-08	4	62	3	31833031
Pubmed	A locus for autosomal recessive pseudoxanthoma elasticum, with penetrance of vascular symptoms in carriers, maps to chromosome 16p13.1.	NOMO2 NOMO3 NOMO1	2.16e-08	4	62	3	9267806
Pubmed	Nicalin and its binding partner Nomo are novel Nodal signaling antagonists.	NOMO2 NOMO3 NOMO1	3.00e-07	8	62	3	15257293
Pubmed	Substrate-driven assembly of a translocon for multipass membrane proteins.	NOMO2 NOMO3 NOMO1	4.50e-07	9	62	3	36261522
Pubmed	An ER translocon for multi-pass membrane protein biogenesis.	NOMO2 NOMO3 NOMO1	8.81e-07	11	62	3	32820719
Pubmed	Short-term inhibition of fibrinolytic system restores locomotor function after spinal cord injury in mice.	LPA PLG	3.13e-06	2	62	2	31690812
Pubmed	Blood-derived plasminogen drives brain inflammation and plaque deposition in a mouse model of Alzheimer's disease.	LPA PLG	3.13e-06	2	62	2	30254165
Pubmed	Plasminogen deficiency exacerbates skeletal muscle loss during mechanical unloading in developing mice.	LPA PLG	3.13e-06	2	62	2	38328826
Pubmed	Reduced transplant arteriosclerosis in plasminogen-deficient mice.	LPA PLG	3.13e-06	2	62	2	9819364
Pubmed	Persistent corneal haze after excimer laser photokeratectomy in plasminogen-deficient mice.	LPA PLG	3.13e-06	2	62	2	10634603
Pubmed	Thrombomodulin functions as a plasminogen receptor to modulate angiogenesis.	LPA PLG	3.13e-06	2	62	2	23943648
Pubmed	In vivo plasminogen deficiency reduces fat accumulation.	LPA PLG	3.13e-06	2	62	2	12083480
Pubmed	Polymorphonuclear leukocyte phagocytic function increases in plasminogen knockout mice.	LPA PLG	3.13e-06	2	62	2	18420257
Pubmed	Plasminogen deficiency causes severe thrombosis but is compatible with development and reproduction.	LPA PLG	3.13e-06	2	62	2	7705657
Pubmed	Nucleocytoplasmic coagulation: an injury-induced aggregation event that disulfide crosslinks proteins and facilitates their removal by plasmin.	LPA PLG	3.13e-06	2	62	2	23041318
Pubmed	Plasminogen alleles influence susceptibility to invasive aspergillosis.	LPA PLG	3.13e-06	2	62	2	18566672
Pubmed	A novel role for plasmin-mediated degradation of opsonizing antibody in the evasion of host immunity by virulent, but not attenuated, Francisella tularensis.	LPA PLG	3.13e-06	2	62	2	19752236
Pubmed	Plasminogen Tochigi: inactive plasmin resulting from replacement of alanine-600 by threonine in the active site.	LPA PLG	3.13e-06	2	62	2	6216475
Pubmed	The generation and characterization of mice expressing a plasmin-inactivating active site mutation.	LPA PLG	3.13e-06	2	62	2	20653841
Pubmed	Influence of plasminogen deficiency on the contribution of polymorphonuclear leucocytes to fibrin/ogenolysis: studies in plasminogen knock-out mice.	LPA PLG	3.13e-06	2	62	2	12428098
Pubmed	Tissue-type plasminogen activator is a neuroprotectant in the mouse hippocampus.	LPA PLG	3.13e-06	2	62	2	20440070
Pubmed	Plasminogen deficiency causes reduced corticospinal axonal plasticity and functional recovery after stroke in mice.	LPA PLG	3.13e-06	2	62	2	24732409
Pubmed	A central role for plasminogen in the inflammatory response to biomaterials.	LPA PLG	3.13e-06	2	62	2	15456492
Pubmed	Plasminogen promotes macrophage phagocytosis in mice.	LPA PLG	3.13e-06	2	62	2	24876560
Pubmed	Plasminogen is a joint-specific positive or negative determinant of arthritis pathogenesis in mice.	LPA PLG	3.13e-06	2	62	2	24574269
Pubmed	Spontaneous development of otitis media in plasminogen-deficient mice.	LPA PLG	3.13e-06	2	62	2	16956791
Pubmed	Staphylococcus aureus manganese transport protein C (MntC) is an extracellular matrix- and plasminogen-binding protein.	LPA PLG	3.13e-06	2	62	2	25409527
Pubmed	The mouse plasminogen locus maps to the recombination breakpoints of the tLub2 and TtOrl partial t haplotypes but is not at the tw73 locus.	LPA PLG	3.13e-06	2	62	2	1543918
Pubmed	Restoration of thrombolytic potential in plasminogen-deficient mice by bolus administration of plasminogen.	LPA PLG	3.13e-06	2	62	2	8704243
Pubmed	Plasmin(ogen) promotes renal interstitial fibrosis by promoting epithelial-to-mesenchymal transition: role of plasmin-activated signals.	LPA PLG	3.13e-06	2	62	2	17267741
Pubmed	Plasmin promotes foam cell formation by increasing macrophage catabolism of aggregated low-density lipoprotein.	LPA PLG	3.13e-06	2	62	2	23702659
Pubmed	Apolipoprotein(a) inhibits the conversion of Glu-plasminogen to Lys-plasminogen on the surface of vascular endothelial and smooth muscle cells.	LPA PLG	3.13e-06	2	62	2	29990619
Pubmed	Reduction of experimental diabetic vascular leakage by delivery of angiostatin with a recombinant adeno-associated virus vector.	LPA PLG	3.13e-06	2	62	2	17293777
Pubmed	Plasminogen plays a crucial role in bone repair.	LPA PLG	3.13e-06	2	62	2	23456978
Pubmed	Disruption of the plasminogen gene in mice abolishes wound healing after myocardial infarction.	LPA PLG	3.13e-06	2	62	2	10854210
Pubmed	Gender affects skin wound healing in plasminogen deficient mice.	LPA PLG	3.13e-06	2	62	2	23527289
Pubmed	Dengue virus-induced autoantibodies bind to plasminogen and enhance its activation.	LPA PLG	3.13e-06	2	62	2	22079981
Pubmed	Plasminogen deficiency differentially affects recruitment of inflammatory cell populations in mice.	LPA PLG	3.13e-06	2	62	2	9490683
Pubmed	Kringle 5 of human plasminogen suppresses hepatocellular carcinoma growth both in grafted and xenografted mice by anti-angiogenic activity.	LPA PLG	3.13e-06	2	62	2	16481742
Pubmed	Apolipoprotein(a) inhibits the conversion of Glu-plasminogen to Lys-plasminogen: a novel mechanism for lipoprotein(a)-mediated inhibition of plasminogen activation.	LPA PLG	3.13e-06	2	62	2	18983515
Pubmed	Plasminogen Regulates Fracture Repair by Promoting the Functions of Periosteal Mesenchymal Progenitors.	LPA PLG	3.13e-06	2	62	2	34378815
Pubmed	Plasmin generation plays different roles in the formation and removal of arterial and venous thrombus in mice.	LPA PLG	3.13e-06	2	62	2	11848464
Pubmed	Effects of disruption of the plasminogen gene on thrombosis, growth, and health in mice.	LPA PLG	3.13e-06	2	62	2	7586361
Pubmed	Plasminogen/plasmin modulates bone metabolism by regulating the osteoblast and osteoclast function.	LPA PLG	3.13e-06	2	62	2	21239499
Pubmed	Plasminogen-independent initiation of the pro-urokinase activation cascade in vivo. Activation of pro-urokinase by glandular kallikrein (mGK-6) in plasminogen-deficient mice.	LPA PLG	3.13e-06	2	62	2	10642175
Pubmed	Plasminogen mRNA induction in the mouse brain after kainate excitation: codistribution with plasminogen activator inhibitor-2 (PAI-2) mRNA.	LPA PLG	3.13e-06	2	62	2	12225871
Pubmed	Fibrinogen deficiency reduces vascular accumulation of apolipoprotein(a) and development of atherosclerosis in apolipoprotein(a) transgenic mice.	LPA PLG	3.13e-06	2	62	2	9770530
Pubmed	Plasminogen activation is required for the development of radiation-induced dermatitis.	LPA PLG	3.13e-06	2	62	2	30323258
Pubmed	Plasminogen deficiency suppresses pancreatic ductal adenocarcinoma disease progression.	LPA PLG	3.13e-06	2	62	2	37971174
Pubmed	The plasminogen activation system enhances brain and heart invasion in murine relapsing fever borreliosis.	LPA PLG	3.13e-06	2	62	2	9884337
Pubmed	Colonic Lesions, Cytokine Profiles, and Gut Microbiota in Plasminogen-Deficient Mice.	LPA PLG	3.13e-06	2	62	2	26473342
Pubmed	Nonfibrinolytic functions of plasminogen.	LPA PLG	3.13e-06	2	62	2	10816371
Pubmed	Plasminogen is a critical regulator of cutaneous wound healing.	LPA PLG	3.13e-06	2	62	2	26791370
Pubmed	Selection of mutant µplasmin for amyloid-β cleavage in vivo.	LPA PLG	3.13e-06	2	62	2	32694536
Pubmed	Angiostatin: a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma.	LPA PLG	3.13e-06	2	62	2	7525077
Pubmed	Potential role of BRCA2 in a mitotic checkpoint after phosphorylation by hBUBR1.	BRCA2 BUB1B	3.13e-06	2	62	2	10749118
Pubmed	Contrasting roles of plasminogen deficiency in different rheumatoid arthritis models.	LPA PLG	3.13e-06	2	62	2	16052596
Pubmed	Functional corpora lutea are formed in matrix metalloproteinase inhibitor-treated plasminogen-deficient mice.	LPA PLG	3.13e-06	2	62	2	17122079
Pubmed	Role of plasminogen in propagation of scrapie.	LPA PLG	3.13e-06	2	62	2	16103174
Pubmed	Differential expression of oxidized/native lipoprotein(a) and plasminogen in human carotid and cerebral artery plaques.	LPA PLG	3.13e-06	2	62	2	21300353
Pubmed	Beta-amyloid (Abeta) causes detachment of N1E-115 neuroblastoma cells by acting as a scaffold for cell-associated plasminogen activation.	LPA PLG	3.13e-06	2	62	2	15737740
Pubmed	Selective behaviors altered in plasminogen-deficient mice are reconstituted with intracerebroventricular injection of plasminogen.	LPA PLG	3.13e-06	2	62	2	11306011
Cytoband	4p16.1	USP17L17 USP17L11 USP17L6P USP17L10 USP17L19 USP17L22 USP17L13 USP17L18	1.67e-13	79	62	8	4p16.1
Cytoband	Ensembl 112 genes in cytogenetic band chr4p16	USP17L17 USP17L11 USP17L6P USP17L10 USP17L19 USP17L22 USP17L13 USP17L18	7.12e-10	222	62	8	chr4p16
Cytoband	Ensembl 112 genes in cytogenetic band chr8p23	USP17L4 USP17L2 USP17L1 USP17L3 CSMD1 USP17L8	7.96e-07	234	62	6	chr8p23
Cytoband	8p23.1	USP17L4 USP17L2 USP17L1 USP17L3 USP17L8	2.21e-06	154	62	5	8p23.1
Cytoband	Ensembl 112 genes in cytogenetic band chr6q26	LPA PLG	2.13e-04	16	62	2	chr6q26
Cytoband	6q26	LPA PLG	2.71e-04	18	62	2	6q26
Cytoband	17q22	AKAP1 HSF5	1.64e-03	44	62	2	17q22
GeneFamily	Transient receptor potential cation channels	TRPC5 TRPM1	8.53e-04	28	28	2	249
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	TRPC5 CSMD1 AKAP1	2.69e-03	181	28	3	694
GeneFamily	Sterile alpha motif domain containing	SCML2 EPHA1	8.15e-03	88	28	2	760
Coexpression	MADAN_DPPA4_TARGETS	USP17L4 USP17L2 USP17L1 USP17L17 USP17L11 USP17L6P USP17L3 USP17L10 USP17L19 USP17L22 USP17L8 USP17L13 USP17L18	1.44e-20	86	62	13	MM1312
Coexpression	GRAESSMANN_RESPONSE_TO_MC_AND_SERUM_DEPRIVATION_DN	USP17L4 USP17L2 USP17L1 USP17L17 USP17L11 USP17L6P USP17L3 USP17L10 USP17L19 USP17L22 USP17L8 USP17L13 USP17L18	5.38e-19	112	62	13	MM1095
Coexpression	GERY_CEBP_TARGETS	USP17L4 USP17L2 USP17L1 USP17L17 USP17L11 USP17L6P USP17L3 USP17L10 USP17L19 USP17L22 USP17L8 USP17L13 USP17L18	6.39e-17	160	62	13	MM1155
Coexpression	GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_UP	ZMAT3 USP17L4 USP17L2 USP17L1 USP17L17 USP17L11 USP17L6P USP17L3 USP17L10 MTARC2 USP17L19 USP17L22 USP17L8 USP17L13 USP17L18	2.09e-11	647	62	15	MM981
Coexpression	MARSON_BOUND_BY_FOXP3_STIMULATED	USP17L4 USP17L2 USP17L1 USP17L17 USP17L11 LPA USP17L6P USP17L3 OS9 USP17L10 USP17L19 LY96 PLG ARIH1 USP17L22 USP17L8 USP17L13 USP17L18	3.00e-11	1072	62	18	MM1031
Coexpression	BRUINS_UVC_RESPONSE_LATE	USP17L4 USP17L2 USP17L1 USP17L17 USP17L11 USP17L6P USP17L3 USP17L10 MTARC2 USP17L19 USP17L22 PCGF5 USP17L8 EPHA1 USP17L13 USP17L18	1.23e-08	1198	62	16	MM1062
Coexpression	GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP	ZMAT3 USP17L4 USP17L2 USP17L1 USP17L17 USP17L11 USP17L6P USP17L3 USP17L10 MTARC2 USP17L19 USP17L22 USP17L8 USP17L13 USP17L18	1.21e-07	1226	62	15	MM979
Coexpression	CUI_DEVELOPING_HEART_TRABECULAR_ATRIAL_CARDIOMYOCYTE	FBN2 RTN4 OS9 AKAP1 NOMO1	6.63e-05	179	62	5	M39308
Coexpression	MARTORIATI_MDM4_TARGETS_NEUROEPITHELIUM_UP	ZMAT3 FBN2 NOMO2 NOMO3 NOMO1	7.75e-05	185	62	5	MM1115
Coexpression	RANKIN_ANGIOGENIC_TARGETS_OF_VHL_HIF2A_UP	LPA PLG	8.21e-05	6	62	2	MM555
Drug	troglitazone; Down 200; 10uM; PC3; HG-U133A	PCNX2 BRCA2 NPRL3 NDRG2 C2CD5 SOS2	5.05e-06	193	52	6	431_DN
Drug	2-propylpentanoic acid; Down 200; 500uM; MCF7; HT_HG-U133A	BRCA2 UBTF MTARC2 AKAP1 FAAH SOS2	5.68e-06	197	52	6	6999_DN
Drug	Aminocaproic Acid	LPA PLG	1.53e-05	3	52	2	DB00513
Disease	primary ovarian insufficiency (implicated_via_orthology)	USP17L4 USP17L2 USP17L1 USP17L17 USP17L11 USP17L6P USP17L3 USP17L10 USP17L19 USP17L22 USP17L8 USP17L13 USP17L18	3.09e-25	46	61	13	DOID:5426 (implicated_via_orthology)
Disease	congenital heart disease (implicated_via_orthology)	USP17L4 USP17L2 USP17L1 USP17L17 USP17L11 USP17L6P USP17L3 USP17L10 USP17L19 USP17L22 USP17L8 USP17L13 USP17L18	1.13e-22	69	61	13	DOID:1682 (implicated_via_orthology)
Disease	chronic kidney disease, APOL1 risk genotype carrier status	LPA PLG	4.19e-05	5	61	2	EFO_0003884, EFO_0009324
Disease	plasma plasminogen measurement	LPA PLG	4.19e-05	5	61	2	EFO_0006309
Disease	angiostatin measurement	LPA PLG	6.27e-05	6	61	2	EFO_0008024
Disease	lipoprotein A measurement, apolipoprotein A 1 measurement	LPA PLG	8.77e-05	7	61	2	EFO_0004614, EFO_0006925
Disease	Childhood Medulloblastoma	SCML2 BRCA2 BRD4	9.78e-05	43	61	3	C0278510
Disease	Melanotic medulloblastoma	SCML2 BRCA2 BRD4	9.78e-05	43	61	3	C1275668
Disease	Medullomyoblastoma	SCML2 BRCA2 BRD4	9.78e-05	43	61	3	C0205833
Disease	Desmoplastic Medulloblastoma	SCML2 BRCA2 BRD4	9.78e-05	43	61	3	C0751291
Disease	Adult Medulloblastoma	SCML2 BRCA2 BRD4	9.78e-05	43	61	3	C0278876
Disease	Medulloblastoma	SCML2 BRCA2 BRD4	1.54e-04	50	61	3	C0025149
Disease	alcoholic liver disease	DHX15 FBN2 MTARC2	6.63e-04	82	61	3	EFO_0008573
Disease	sphingomyelin 22:0 measurement	ACTN2 CSMD1	7.80e-04	20	61	2	EFO_0010395
Disease	pantothenic acid mesurement	LY96 RECK	7.80e-04	20	61	2	EFO_0010519
Disease	Deep Vein Thrombosis	LPA PLG	8.61e-04	21	61	2	C0149871
Disease	Venous Thrombosis	LPA PLG	8.61e-04	21	61	2	C0042487
Disease	triglycerides:total lipids ratio, high density lipoprotein cholesterol measurement	FZD9 LPA PLG STAT5B	8.82e-04	206	61	4	EFO_0004612, EFO_0020947
Disease	sleep duration, low density lipoprotein cholesterol measurement	LPA PLG PKD1L3	8.97e-04	91	61	3	EFO_0004611, EFO_0005271
Disease	chylomicron measurement, very low density lipoprotein cholesterol measurement	FZD9 LPA PLG	1.39e-03	106	61	3	EFO_0008317, EFO_0008596
Disease	chylomicron measurement, very low density lipoprotein cholesterol measurement, phospholipid measurement	FZD9 LPA PLG	1.51e-03	109	61	3	EFO_0004639, EFO_0008317, EFO_0008596
Disease	free cholesterol measurement, chylomicron measurement, very low density lipoprotein cholesterol measurement	FZD9 LPA PLG	1.55e-03	110	61	3	EFO_0008317, EFO_0008591, EFO_0008596
Disease	Beta blocking agent use measurement	FBN2 LPA NPRL3	1.72e-03	114	61	3	EFO_0009929
Disease	glycoprotein measurement	LPA PLG PKD1L3	1.94e-03	119	61	3	EFO_0004555

Protein segments in the cluster

Peptide	Gene	Start	Entry
LCNEPLDMYSYLHNQ	BUB1B	131	O60566
QILNGTPLYMYQDCP	EPHA1	56	P21709
QQMYLCYSQPGIPTL	AKAP1	741	Q92667
PDQAQYCIKRMPAYS	ACTN2	856	P35609
LSPNYPEEYGNNMNC	CSMD1	596	Q96PZ7
DVRLMFSNCYKYNPP	BRD4	421	O60885
YLDFYMQNTPGLPQC	DCP2	46	Q8IU60
IAPQYYDMSNFPQCE	DHX15	761	O43143
CAPNNGYFMIPLYDK	NOMO3	71	P69849
HCVNNYTQSYPMRNP	RECK	196	O95980
MYIPLDPDYNADCPN	SPINK13	41	Q1W4C9
AQDMPCQICYLNYPN	ARIH1	181	Q9Y4X5
CAPNNGYFMIPLYDK	NOMO2	71	Q5JPE7
QVCSQDGPLYQSYPM	PCGF5	231	Q86SE9
MTNNYSYPPCTLTDE	INTS1	771	Q8N201
LINSSCDQPLGYPMY	PCNX2	1816	A6NKB5
YPLCENNVYMLSPNA	NPRL3	326	Q12980
NNVYMLSPNASVCLY	NPRL3	331	Q12980
CAPNNGYFMIPLYDK	NOMO1	71	Q15155
QYPERPIIFLSMCYN	FZD9	261	O00144
SNYPALLKCPDYDQM	CACNG5	256	Q9UF02
LMSSPNCEIYYQSPL	BRCA2	3216	P51587
NYPNAGLIMNYCRNP	LPA	66	P08519
YPNAGLIMNYCRNPD	LPA	181	P08519
IMNYCRNPDAVAAPY	LPA	301	P08519
MNYCRNPDAVAAPYC	LPA	416	P08519
YPNAGLIMNYCRNPD	LPA	751	P08519
IMNYCRNPDPVAAPY	LPA	871	P08519
TPENYPNDGLTMNYC	LPA	1651	P08519
ELCMNLPYNSTSYPN	CORIN	461	Q9Y5Q5
NFQVAYPDYCPLLIM	MTARC2	201	Q969Z3
YCDKMQYPISINVNP	LY96	36	Q9Y6Y9
YALYKQATEGPCNMP	ECI2	66	O75521
NVPQSMFSYDCSNPL	FAAH	186	O00519
TLGNYTCICPPEYMQ	FBN2	1711	P35556
ELNMPFPAHLTYCYN	C2CD5	471	Q86YS7
VNYMCPLNSDGYPDS	DDB1	676	Q16531
YYPQNNISSCMGYPD	MOXD2P	471	A6NHM9
QVNAALLDYTMCNYP	NR5A2	476	O00482
MQESLYPAAQLCPSF	RTN4	586	Q9NQC3
PNSEANPLNAYYLKC	RTTN	2201	Q86VV8
CNYFQNPSMQSSYPV	HSF5	336	Q4G112
QYQNQPYCLRIEPDM	SOS2	971	Q07890
YQYPSLDQLADMIPC	NDRG2	116	Q9UN36
LMTLYLGFQYQPNCT	PKD1L3	556	Q7Z443
PIDQNMYPNQRDSAY	SHROOM4	176	Q9ULL8
SPAVCPQAHYNMYPQ	STAT5B	731	P51692
YPNAGLTMNYCRNPD	PLG	416	P00747
CHPSLQPEEYMAYVQ	OS9	246	Q13438
PSNPYCACYMSLFQV	MC2R	246	Q01718
QYPECLDMQPYMSQQ	USP17L3	296	A6NCW0
QYPECLDMQPYMSQQ	USP17L4	296	A6NCW7
SGNYLNPACRNPMYI	SCML2	551	Q9UQR0
QYPECLDMQPYMSQT	USP17L18	296	D6R9N7
QYPECLDMQPYMSQQ	USP17L13	296	C9JLJ4
QYPECLDMQPYMSQT	USP17L19	296	D6RCP7
QYPECLDMQPYMSQQ	USP17L1	296	Q7RTZ2
LYAMEINPPCGENLY	TRPM1	1021	Q7Z4N2
YYAANSCPPPARMSN	ZMAT3	101	Q9HA38
QYPECLDMQPYMSQQ	USP17L8	296	P0C7I0
PPYRQMFYQLCDLNV	GTF3C5	401	Q9Y5Q8
EIYYNVNINCMDPLG	TRPC5	56	Q9UL62
QYPECLDMQPYMSQQ	USP17L6P	296	Q6QN14
PPNSYSLYCAELMAN	UBTF	301	P17480
QYPECLDMQPYMSQQ	USP17L22	296	D6RA61
QYPECLDMQPYMSQQ	USP17L17	296	D6RBQ6
QYPECLDMQPYMSQQ	USP17L2	296	Q6R6M4
QCLTYKPPLANYMLF	USP17L10	96	C9JJH3
QYPECLDMQPYMSQQ	USP17L10	296	C9JJH3
QYPECLDMQPYMSQT	USP17L11	296	C9JVI0