Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	interleukin-22 receptor activity	IL22RA1 IFNAR2	1.28e-04	3	131	2	GO:0042018
GeneOntologyMolecularFunction	signaling adaptor activity	DAB2IP NLRP1 CARD10 IFNAR2 KSR1 GAB4	2.09e-04	129	131	6	GO:0035591
GeneOntologyMolecularFunction	cargo receptor activity	MRC1 LRP12 MIA3 SCARF2 SSC5D	2.43e-04	85	131	5	GO:0038024
GeneOntologyMolecularFunction	interferon receptor activity	IL22RA1 IFNAR2	4.22e-04	5	131	2	GO:0004904
Domain	FN_type2_col-bd	MRC1 MRC2 LY75	1.06e-04	14	127	3	IPR000562
Domain	FN2_2	MRC1 MRC2 LY75	1.06e-04	14	127	3	PS51092
Domain	FN2_1	MRC1 MRC2 LY75	1.06e-04	14	127	3	PS00023
Domain	fn2	MRC1 MRC2 LY75	1.06e-04	14	127	3	PF00040
Domain	FN2	MRC1 MRC2 LY75	1.06e-04	14	127	3	SM00059
Domain	C-type_lectin_CS	MRC1 BCAN MRC2 LY75	2.05e-04	43	127	4	IPR018378
Domain	Sterol-sensing	SCAP PTCH2	4.53e-04	5	127	2	PF12349
Domain	PH_dom-like	DAB2IP CNKSR1 TRIO CDC42BPB RGS12 PLEKHH3 SHC2 GAB4 TNS1 SNTA1	6.69e-04	426	127	10	IPR011993
Domain	SPOC_C	DIDO1 SPOCD1	6.76e-04	6	127	2	IPR012921
Domain	SPOC	DIDO1 SPOCD1	6.76e-04	6	127	2	PF07744
Domain	RICIN	MRC1 MRC2 LY75	8.88e-04	28	127	3	SM00458
Domain	RICIN_B_LECTIN	MRC1 MRC2 LY75	8.88e-04	28	127	3	PS50231
Domain	TFS2M	DIDO1 SPOCD1	9.42e-04	7	127	2	SM00510
Domain	TFIIS_M	DIDO1 SPOCD1	9.42e-04	7	127	2	PF07500
Domain	Ricin_B_lectin	MRC1 MRC2 LY75	1.09e-03	30	127	3	IPR000772
Domain	TFIIS_cen_dom	DIDO1 SPOCD1	1.25e-03	8	127	2	IPR003618
Domain	-	DIDO1 SPOCD1	1.25e-03	8	127	2	1.10.472.30
Domain	TFIIS_CENTRAL	DIDO1 SPOCD1	1.25e-03	8	127	2	PS51321
Domain	Kringle-like	MRC1 MRC2 LY75	1.32e-03	32	127	3	IPR013806
Domain	-	DAB2IP CNKSR1 TRIO CDC42BPB RGS12 PLEKHH3 SHC2 GAB4 TNS1	1.42e-03	391	127	9	2.30.29.30
Domain	-	COL7A1 TRIO ICAM4 IGSF5 BCAN IL22RA1 IFNAR2 CD19 NFATC3 PTPRO ROBO2 HCFC2	1.89e-03	663	127	12	2.60.40.10
Domain	Interfer-bind	IL22RA1 IFNAR2	1.99e-03	10	127	2	PF09294
Domain	Interferon/interleukin_rcp_dom	IL22RA1 IFNAR2	1.99e-03	10	127	2	IPR015373
Domain	C_TYPE_LECTIN_1	MRC1 BCAN MRC2 LY75	2.16e-03	80	127	4	PS00615
Domain	PTB	RGS12 SHC2 TNS1	2.52e-03	40	127	3	SM00462
Domain	Lectin_C	MRC1 BCAN MRC2 LY75	2.59e-03	84	127	4	PF00059
Domain	CLECT	MRC1 BCAN MRC2 LY75	2.59e-03	84	127	4	SM00034
Domain	C_TYPE_LECTIN_2	MRC1 BCAN MRC2 LY75	2.70e-03	85	127	4	PS50041
Domain	PTB/PI_dom	RGS12 SHC2 TNS1	2.71e-03	41	127	3	IPR006020
Domain	C-type_lectin-like	MRC1 BCAN MRC2 LY75	2.82e-03	86	127	4	IPR001304
Domain	Tissue_fac	IL22RA1 IFNAR2	2.90e-03	12	127	2	PF01108
Domain	Tissue_factor	IL22RA1 IFNAR2	2.90e-03	12	127	2	IPR001187
Domain	PH	DAB2IP CNKSR1 TRIO CDC42BPB PLEKHH3 GAB4 SNTA1	2.94e-03	278	127	7	SM00233
Domain	PH_DOMAIN	DAB2IP CNKSR1 TRIO CDC42BPB PLEKHH3 GAB4 SNTA1	3.00e-03	279	127	7	PS50003
Domain	PH_domain	DAB2IP CNKSR1 TRIO CDC42BPB PLEKHH3 GAB4 SNTA1	3.06e-03	280	127	7	IPR001849
Domain	FN3_dom	COL7A1 IL22RA1 IFNAR2 PTPRO ROBO2 HCFC2	3.08e-03	209	127	6	IPR003961
Domain	Ig-like_fold	COL7A1 TRIO ICAM4 IGSF5 BCAN IL22RA1 IFNAR2 CD19 NFATC3 PTPRO ROBO2 HCFC2	3.16e-03	706	127	12	IPR013783
Domain	SSD	SCAP PTCH2	3.41e-03	13	127	2	IPR000731
Domain	SSD	SCAP PTCH2	3.41e-03	13	127	2	PS50156
Domain	-	MRC1 MRC2	3.41e-03	13	127	2	2.10.10.10
Domain	-	LRP12 LDLRAD2 ALK	3.77e-03	46	127	3	4.10.400.10
Domain	LDrepeatLR_classA_rpt	LRP12 LDLRAD2 ALK	4.50e-03	49	127	3	IPR002172
Domain	LDLa	LRP12 LDLRAD2 ALK	4.50e-03	49	127	3	SM00192
Domain	LDLRA_2	LRP12 LDLRAD2 ALK	4.50e-03	49	127	3	PS50068
Domain	C-type_lectin-like/link	MRC1 BCAN MRC2 LY75	4.67e-03	99	127	4	IPR016186
Domain	-	LRP12 LDLRAD2 CSMD2	5.32e-03	52	127	3	2.60.120.290
Domain	CTDL_fold	MRC1 BCAN MRC2 LY75	6.14e-03	107	127	4	IPR016187
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	VWA5B2 DAB2IP TRPM4 PCNX3 TRIO PPRC1 DYRK1A IRAK1 CARD10 BCL9 CDC42BPB PLEKHH3 LPIN3 SCAP RPAP1 KCNH2 TMEM132A CABIN1 SOWAHB HR	9.69e-09	1105	134	20	35748872
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	DAB2IP NES LIMA1 MIA3 ZNF219 CTTNBP2 TRIO DYRK1A DIDO1 SYNPO BCL9 GRM2 CDC42BPB UBA1 NFATC3 CABIN1 TNS1	1.95e-07	963	134	17	28671696
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	NES LIMA1 USP22 TRIO DYRK1A KIAA1191 ZYX RGS12 RUSC2 LPIN3 KSR1 NFATC3 USP54 MEX3B	6.43e-06	861	134	14	36931259
Pubmed	Wnt produced by stretched roof-plate cells is required for the promotion of cell proliferation around the central canal of the spinal cord.	NES NEUROG1 GDF7	9.02e-06	11	134	3	30651295
Pubmed	Evidence for intrinsic development of olfactory structures in Pax-6 mutant mice.	NES TH ROBO2	9.02e-06	11	134	3	11074448
Pubmed	Oligomerization of the macrophage mannose receptor enhances gp120-mediated binding of HIV-1.	MRC1 MRC2	1.47e-05	2	134	2	19224860
Pubmed	Mannose receptor regulation of macrophage cell migration.	MRC1 MRC2	1.47e-05	2	134	2	17596337
Pubmed	Association of human mannose receptor in sexual transmission of human immunodeficiency virus in serodiscordant couples.	MRC1 MRC2	1.47e-05	2	134	2	23148569
Pubmed	CD4-independent infection of astrocytes by human immunodeficiency virus type 1: requirement for the human mannose receptor.	MRC1 MRC2	1.47e-05	2	134	2	15047828
Pubmed	Noninfectious entry of HIV-1 into peripheral and brain macrophages mediated by the mannose receptor.	MRC1 MRC2	1.47e-05	2	134	2	17360361
Pubmed	TANGO1 recruits ERGIC membranes to the endoplasmic reticulum for procollagen export.	COL7A1 MIA3	1.47e-05	2	134	2	26568311
Pubmed	HIV-1 Tat represses transcription from the mannose receptor promoter.	MRC1 MRC2	1.47e-05	2	134	2	11120831
Pubmed	The mannose receptor on murine liver sinusoidal endothelial cells is the main denatured collagen clearance receptor.	MRC1 MRC2	1.47e-05	2	134	2	17518370
Pubmed	The USP22 promotes the growth of cancer cells through the DYRK1A in pancreatic ductal adenocarcinoma.	USP22 DYRK1A	1.47e-05	2	134	2	32687947
Pubmed	Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.	TRIO CARD10 POLR2M SYNPO PLEKHH3 PHF1 THAP4 KSR1 SMG7 SLC4A1AP ROBO2 MAML2	1.55e-05	689	134	12	36543142
Pubmed	The human cytoplasmic dynein interactome reveals novel activators of motility.	MIA3 TRIO FPGS ENTR1 DYRK1A IRAK1 KIAA1191 RGS12 SMG7 NFATC3 PROSER3 TNRC6A USP54	2.74e-05	853	134	13	28718761
Pubmed	Neurogenin 2 is required for the development of ventral midbrain dopaminergic neurons.	NES TH NEUROG1	3.02e-05	16	134	3	16410412
Pubmed	Delayed dopaminergic neuron differentiation in Lrp6 mutant mice.	NES TH NEUROG1	3.66e-05	17	134	3	19795519
Pubmed	Distribution of murine mannose receptor expression from early embryogenesis through to adulthood.	MRC1 MRC2	4.41e-05	3	134	2	9560474
Pubmed	Three Novel Genetic Variants in the FAM110D, CACNA1A, and NLRP12 Genes Are Associated With Susceptibility to Hypertension Among Dai People.	FAM110D NLRP1	4.41e-05	3	134	2	33621312
Pubmed	Role of cannabinoid CB2 receptor in the reinforcing actions of ethanol.	OPRM1 TH	4.41e-05	3	134	2	23855434
Pubmed	HIV gp120 binds to mannose receptor on vaginal epithelial cells and induces production of matrix metalloproteinases.	MRC1 MRC2	4.41e-05	3	134	2	22132194
Pubmed	HIV-1 interaction with human mannose receptor (hMR) induces production of matrix metalloproteinase 2 (MMP-2) through hMR-mediated intracellular signaling in astrocytes.	MRC1 MRC2	4.41e-05	3	134	2	15955449
Pubmed	Molecular and genetic insights into progressive cardiac conduction disease.	TRPM4 KCNH2	4.41e-05	3	134	2	31087102
Pubmed	Distinct isoform-specific complexes of TANGO1 cooperatively facilitate collagen secretion from the endoplasmic reticulum.	COL7A1 MIA3	4.41e-05	3	134	2	27413011
Pubmed	Immune regulation by fibroblasts in tissue injury depends on uPARAP-mediated uptake of collectins.	MRC1 MRC2	4.41e-05	3	134	2	30366943
Pubmed	Neurospheres derived from human embryoid bodies treated with retinoic Acid show an increase in nestin and ngn2 expression that correlates with the proportion of tyrosine hydroxylase-positive cells.	NES TH	4.41e-05	3	134	2	17784840
Pubmed	DYRK1A controls the transition from proliferation to quiescence during lymphoid development by destabilizing Cyclin D3.	DYRK1A CD19	4.41e-05	3	134	2	26008897
Pubmed	Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.	CSMD2 IL22RA1 GAB4 ROBO2 MAML2 TOX2 TNS1	7.94e-05	265	134	7	19240061
Pubmed	EphB1 null mice exhibit neuronal loss in substantia nigra pars reticulata and spontaneous locomotor hyperactivity.	OPRM1 TH	8.80e-05	4	134	2	17561836
Pubmed	TANGO1 facilitates cargo loading at endoplasmic reticulum exit sites.	COL7A1 MIA3	8.80e-05	4	134	2	19269366
Pubmed	Murine Ksr interacts with MEK and inhibits Ras-induced transformation.	CNKSR1 KSR1	8.80e-05	4	134	2	9427625
Pubmed	The H2B deubiquitinase Usp22 promotes antibody class switch recombination by facilitating non-homologous end joining.	USP22 CD19	8.80e-05	4	134	2	29520062
Pubmed	CD44 binds to macrophage mannose receptor on lymphatic endothelium and supports lymphocyte migration via afferent lymphatics.	MRC1 LY75	8.80e-05	4	134	2	23603511
Pubmed	Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations.	DYRK1A CDC42BPB	8.80e-05	4	134	2	22495309
Pubmed	Loss of Roquin induces early death and immune deregulation but not autoimmunity.	IL22RA1 CD19	8.80e-05	4	134	2	21844204
Pubmed	M2-like macrophages are responsible for collagen degradation through a mannose receptor-mediated pathway.	MRC1 MRC2	8.80e-05	4	134	2	24019537
Pubmed	Induction of complement-fixing autoantibodies against type VII collagen results in subepidermal blistering in mice.	COL7A1 HR	8.80e-05	4	134	2	16920988
Pubmed	Patterning of the lateral ganglionic eminence by the Gsh1 and Gsh2 homeobox genes regulates striatal and olfactory bulb histogenesis and the growth of axons through the basal ganglia.	NES OPRM1 TH	1.36e-04	26	134	3	12724834
Pubmed	Neuropathy correlated with imbalanced Foxp3/IL-17 in bone marrow microenvironment of patients with acute myeloid leukemia.	NES TH	1.46e-04	5	134	2	27016413
Pubmed	Carbohydrate-specific signaling through the DC-SIGN signalosome tailors immunity to Mycobacterium tuberculosis, HIV-1 and Helicobacter pylori.	CNKSR1 KSR1	1.46e-04	5	134	2	19718030
Pubmed	Midbrain dopaminergic axons are guided longitudinally through the diencephalon by Slit/Robo signals.	TH ROBO2	1.46e-04	5	134	2	21118670
Pubmed	Generation of conditional ALK F1174L mutant mouse models for the study of neuroblastoma pathogenesis.	TH ALK	1.46e-04	5	134	2	31218818
Pubmed	Expression of PINK1 in the brain, eye and ear of mouse during embryonic development.	NES TH	1.46e-04	5	134	2	21126574
Pubmed	A unique expression pattern of Tbx10 in the hindbrain as revealed by Tbx10(LacZ) allele.	TH TBX10	1.46e-04	5	134	2	20162674
Pubmed	Neuregulin 1-erbB2 signaling is required for the establishment of radial glia and their transformation into astrocytes in cerebral cortex.	NES NEUROG1	1.46e-04	5	134	2	12649319
Pubmed	A protein-protein interaction map of the TNF-induced NF-κB signal transduction pathway.	ENTR1 DYRK1A THAP4 MRC2 TNRC6A ROBO2 USP54	1.78e-04	302	134	7	30561431
Pubmed	A systematic screen for CDK4/6 substrates links FOXM1 phosphorylation to senescence suppression in cancer cells.	ZNF219 ZFP36 NFATC3 SLBP	1.87e-04	73	134	4	22094256
Pubmed	A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.	DAB2IP ENTR1 DYRK1A IRAK1 POLR2M KIAA1191 ZYX ZFP36 RUSC2 LPIN3 KSR1 SMG7 RPAP1	1.96e-04	1038	134	13	26673895
Pubmed	Increased dosage of DYRK1A and DSCR1 delays neuronal differentiation in neocortical progenitor cells.	DYRK1A NFATC3	2.19e-04	6	134	2	24352425
Pubmed	CCL2/MCP-1 signaling drives extracellular matrix turnover by diverse macrophage subsets.	MRC1 MRC2	2.19e-04	6	134	2	33543002
Pubmed	HIV-1 Tat interaction with cyclin T1 represses mannose receptor and the bone morphogenetic protein receptor-2 transcription.	MRC1 MRC2	2.19e-04	6	134	2	16615932
Pubmed	Mind bomb 1 is essential for generating functional Notch ligands to activate Notch.	NES NEUROG1 MAML2	2.80e-04	33	134	3	16000382
Pubmed	Mash1 is required for glomus cell formation in the mouse carotid body.	NES TH	3.06e-04	7	134	2	15878769
Pubmed	NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21.	DYRK1A NFATC3	3.06e-04	7	134	2	16554754
Pubmed	Aberrant trajectory of ascending dopaminergic pathway in mice lacking Nkx2.1.	NES TH	3.06e-04	7	134	2	12821380
Pubmed	Ras regulates assembly of mitogenic signalling complexes through the effector protein IMP.	CNKSR1 KSR1	3.06e-04	7	134	2	14724641
Pubmed	Lack of the endosomal SNAREs vti1a and vti1b led to significant impairments in neuronal development.	NES TH	3.06e-04	7	134	2	21262811
Pubmed	HIV-1 envelope triggers polyclonal Ig class switch recombination through a CD40-independent mechanism involving BAFF and C-type lectin receptors.	MRC1 MRC2	3.06e-04	7	134	2	16547227
Pubmed	Cxcl12/Cxcr4 signaling controls the migration and process orientation of A9-A10 dopaminergic neurons.	NES TH	3.06e-04	7	134	2	24154522
Pubmed	Analysis of the midbrain-hindbrain boundary cell fate using a boundary cell-specific Cre-mouse strain.	TH CDH22	3.06e-04	7	134	2	18196597
Pubmed	Trio GEF mediates RhoA activation downstream of Slit2 and coordinates telencephalic wiring.	TRIO ROBO2	4.06e-04	8	134	2	30177526
Pubmed	NCAM and polysialyltransferase profiles match dopaminergic marker gene expression but polysialic acid is dispensable for development of the midbrain dopamine system.	NES TH	4.06e-04	8	134	2	19619134
Pubmed	EphA receptors direct the differentiation of mammalian neural precursor cells through a mitogen-activated protein kinase-dependent pathway.	NES TH	4.06e-04	8	134	2	15145949
Pubmed	HGprt deficiency disrupts dopaminergic circuit development in a genetic mouse model of Lesch-Nyhan disease.	NES TH	4.06e-04	8	134	2	35660973
Pubmed	Thyroid Hormone-Otx2 Signaling Is Required for Embryonic Ventral Midbrain Neural Stem Cells Differentiated into Dopamine Neurons.	NES TH	4.06e-04	8	134	2	25867707
Pubmed	Abnormalities of motor function, transcription and cerebellar structure in mouse models of THAP1 dystonia.	OPRM1 TH	4.06e-04	8	134	2	26376866
Pubmed	Transient expression of MIDC-8 in the normal mouse brain.	NES LY75	4.06e-04	8	134	2	15755524
Pubmed	GTPase activating specificity of RGS12 and binding specificity of an alternatively spliced PDZ (PSD-95/Dlg/ZO-1) domain.	GRM2 RGS12	4.06e-04	8	134	2	9651375
Pubmed	Defining the molecular character of the developing and adult kidney podocyte.	NES SYNPO PTPRO	4.62e-04	39	134	3	21931791
Pubmed	The protomap is propagated to cortical plate neurons through an Eomes-dependent intermediate map.	LIMA1 BCAN PTPRO ROBO2	4.91e-04	94	134	4	23431145
Pubmed	Retinal ganglion cell axon guidance in the mouse optic chiasm: expression and function of robos and slits.	NES ROBO2	5.21e-04	9	134	2	10864955
Pubmed	Expression and possible roles of extracellular signal-related kinases 1-2 (ERK1-2) in mouse primordial germ cell development.	SOHLH1 NOBOX	5.21e-04	9	134	2	32418930
Pubmed	Transforming growth factor beta is required for differentiation of mouse mesencephalic progenitors into dopaminergic neurons in vitro and in vivo: ectopic induction in dorsal mesencephalon.	NES TH	5.21e-04	9	134	2	16741229
Pubmed	A complementary role for the tetraspanins CD37 and Tssc6 in cellular immunity.	CD19 LY75	5.21e-04	9	134	2	20709950
Pubmed	Interleukin-10-deficient mice develop chronic enterocolitis.	NES TH	5.21e-04	9	134	2	8402911
Pubmed	The mammalian ShcB and ShcC phosphotyrosine docking proteins function in the maturation of sensory and sympathetic neurons.	TH SHC2	5.21e-04	9	134	2	11163269
Pubmed	RECK modulates Notch signaling during cortical neurogenesis by regulating ADAM10 activity.	NES NEUROG1	5.21e-04	9	134	2	17558399
Pubmed	PITX2 is required for normal development of neurons in the mouse subthalamic nucleus and midbrain.	NES TH	5.21e-04	9	134	2	14975719
Pubmed	Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes?	LIMA1 OPRM1 CDH22 TMEM132A TNRC6A	5.28e-04	170	134	5	23314748
Pubmed	Information provided by the skeletal muscle and associated neurons is necessary for proper brain development.	NES TH	6.50e-04	10	134	2	12485625
Pubmed	Slit/Robo signals prevent spinal motor neuron emigration by organizing the spinal cord basement membrane.	NES ROBO2	6.50e-04	10	134	2	31356769
Pubmed	Voltage-gated potassium channel EAG2 controls mitotic entry and tumor growth in medulloblastoma via regulating cell volume dynamics.	NES KCNH2	6.50e-04	10	134	2	22855790
Pubmed	Emergence of the sensory nervous system as defined by Foxs1 expression.	TH NEUROG1	6.50e-04	10	134	2	17309606
Pubmed	Inhibitory effects of Robo2 on nephrin: a crosstalk between positive and negative signals regulating podocyte structure.	SYNPO ROBO2	6.50e-04	10	134	2	22840396
Pubmed	Radial and tangential migration of telencephalic somatostatin neurons originated from the mouse diagonal area.	NES TH	6.50e-04	10	134	2	26189100
Pubmed	Differential expression and dynamic changes of murine NEDD9 in progenitor cells of diverse tissues.	NES TH	6.50e-04	10	134	2	18282814
Pubmed	Defects During Mecp2 Null Embryonic Cortex Development Precede the Onset of Overt Neurological Symptoms.	NES GRM2 KCNH2	7.05e-04	45	134	3	25979088
Pubmed	Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	DIDO1 NACAD RUSC2 CABIN1	7.19e-04	104	134	4	9205841
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	DAB2IP MIA3 DDX31 TRIO ENTR1 CDC42BPB ZYX UBA1 SMG7 SLC4A1AP TNRC6A TNS1	7.72e-04	1049	134	12	27880917
Pubmed	Anuria, omphalocele, and perinatal lethality in mice lacking the CD34-related protein podocalyxin.	SYNPO PTPRO	7.92e-04	11	134	2	11435469
Pubmed	SIP1 expression patterns in brain investigated by generating a SIP1-EGFP reporter knock-in mouse.	GRM2 TH	7.92e-04	11	134	2	24243579
Pubmed	Temporally and Spatially Regulated Expression of the Linker Histone H1fx During Mouse Development.	NES TH	7.92e-04	11	134	2	28766996
Pubmed	Abnormal retinal development in the Btrc null mouse.	NES TH	7.92e-04	11	134	2	19705444
Pubmed	Expression of Neurogenin 1 in mouse embryonic stem cells directs the differentiation of neuronal precursors and identifies unique patterns of down-stream gene expression.	NES NEUROG1	7.92e-04	11	134	2	23288605
Pubmed	Slit proteins prevent midline crossing and determine the dorsoventral position of major axonal pathways in the mammalian forebrain.	TH ROBO2	7.92e-04	11	134	2	11804571
Pubmed	The spatio-temporal and subcellular expression of the candidate Down syndrome gene Mnb/Dyrk1A in the developing mouse brain suggests distinct sequential roles in neuronal development.	NES DYRK1A	7.92e-04	11	134	2	18364031
Pubmed	BTG1 mutation yields supercompetitive B cells primed for malignant transformation.	CD19 LY75	7.92e-04	11	134	2	36656933
Pubmed	The terminal nerve plays a prominent role in GnRH-1 neuronal migration independent from proper olfactory and vomeronasal connections to the olfactory bulbs.	TH ROBO2	7.92e-04	11	134	2	28970231
Pubmed	Urogenital and caudal dysgenesis in adrenocortical dysplasia (acd) mice is caused by a splicing mutation in a novel telomeric regulator.	TH NFATC3 TMEM208	8.01e-04	47	134	3	15537664
Cytoband	1p36.11	CNKSR1 ZDHHC18 FAM110D IL22RA1	4.75e-05	68	133	4	1p36.11
GeneFamily	C2-set domain containing\|Immunoglobulin like domain containing\|Scavenger receptors	MRC1 SCARF2 SSC5D LY75	5.22e-06	27	78	4	1253
GeneFamily	C-type lectin domain family	MRC1 MRC2 LY75	1.09e-03	47	78	3	494
GeneFamily	ADAM metallopeptidase domain containing\|CD molecules	MRC1 SPN ICAM4 CD19 MRC2 LY75 ALK	1.55e-03	394	78	7	471
Coexpression	GSE37532_TREG_VS_TCONV_CD4_TCELL_FROM_VISCERAL_ADIPOSE_TISSUE_UP	DAB2IP NES BCAN MRC2 ROBO2 TOX2 ALK INPP5J	4.58e-07	136	132	8	M8939
Coexpression	GSE18281_SUBCAPSULAR_CORTICAL_REGION_VS_WHOLE_MEDULLA_THYMUS_UP	COL7A1 CNKSR1 MIA3 NLRP1 BCL9 ZYX TMEM132A RNF39	7.90e-06	199	132	8	M7254
Coexpression	GSE3982_DC_VS_TH2_UP	ASPHD1 TRIO PPP1R15A IFNAR2 PHF1 TH MRC2 TNS1	8.20e-06	200	132	8	M5484
ToppCell	TCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-4\|TCGA-Prostate / Sample_Type by Project: Shred V9	NLRP1 SYNPO NACAD ZYX RUSC2 KSR1 ZNF469 MRC2	1.33e-07	195	133	8	5562665dd3beb70e2358aa32611a337bef5731c1
ToppCell	PND10-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP2-CAP2_G2M\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	LRP12 FAM110D RGS12 ZFP36 IFNAR2 PHF1 USP54	1.14e-06	179	133	7	327cc39161741ddbc4e8d45b9b3d30b3ce508929
ToppCell	TCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Colon_Adenocarcinoma-7\|TCGA-Colorectal / Sample_Type by Project: Shred V9	TRIO OLFML2B LRRC32 DIDO1 RUSC2 ZNF469 MRC2	1.59e-06	188	133	7	14bc73cf79c79c9f208369fd8d498e5b26e0114d
ToppCell	Parenchymal-10x5prime-Endothelial-Endothelia_vascular-VE_systemic_arterial\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	NES LRRC32 APLP1 GRM2 SHC2 TMEM132A TOX2	2.17e-06	197	133	7	ad4a3b5da2190be9495382a2952991e1de9f190d
ToppCell	Caecum-ILC\|Caecum / Region, Cell class and subclass	IGSF5 PTGER1 HOXA9 MRC2 MAML2 TOX2 MEX3B	2.39e-06	200	133	7	a9a1f03b4f415da860fb52eaedb07f0743692c98
ToppCell	Caecum-(3)_ILC-(30)_ILC\|Caecum / shred on region, Cell_type, and subtype	IGSF5 PTGER1 HOXA9 MRC2 MAML2 TOX2 MEX3B	2.39e-06	200	133	7	ccd323997613b65f0189c0c66d76fbf273e18c03
ToppCell	Caecum-ILC-ILC\|Caecum / Region, Cell class and subclass	IGSF5 PTGER1 HOXA9 MRC2 MAML2 TOX2 MEX3B	2.39e-06	200	133	7	3ac18c3ef335cb83d6a826f6c7519a5e7804929d
ToppCell	Caecum-(3)_ILC\|Caecum / shred on region, Cell_type, and subtype	IGSF5 PTGER1 HOXA9 MRC2 MAML2 TOX2 MEX3B	2.39e-06	200	133	7	6857863b3200162c250123688af2cba681afcb35
ToppCell	(5)_Fibroblast-B_(Myofibroblast)\|World / Lung cell shreds - cell class (v4) and cell subclass (v4)	SCARF2 OLFML2B PTGER1 SSC5D MRC2 ROBO2 HR	2.39e-06	200	133	7	9bbaa666d0f3b4782c1b4b95e0fa5fc1467842d8
ToppCell	droplet-Liver-Hepatocytes-24m-Myeloid-macrophage/monocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPN NLRP1 PHF1 PTPRO SLC9A7 RELT	7.81e-06	157	133	6	d8e283414a770f05d71f0455d0822e9a9660b115
ToppCell	droplet-Liver-Hepatocytes-24m-Myeloid-myeloid_leukocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPN NLRP1 PHF1 PTPRO SLC9A7 RELT	7.81e-06	157	133	6	165e98bf944572cafbc06ef43c9eab7bd6bea1c2
ToppCell	PBMC-Mild-Myeloid-cDC-cDC-cDC_6\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	MRC1 ICAM4 HOXA9 ZNF469 HACD1 INPP5J	8.39e-06	159	133	6	6115cb03c2ad08e4c1b65893d522f685ff0bc692
ToppCell	PBMC-Mild-Myeloid-cDC-cDC-cDC_6\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	MRC1 ICAM4 HOXA9 ZNF469 HACD1 INPP5J	8.70e-06	160	133	6	a90eb621481fd07a821495db07d1032e109fd386
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Degenerative_Podocyte\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	NES ZNF219 APLP1 SYNPO ZNF469 PTPRO	1.07e-05	166	133	6	dc443a3327dc8f9a0d808c3c6e06b0834d45f5c2
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c12-FOXP3\|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)	LIMA1 ZNF446 THAP4 SSC5D SCAP TOX2	1.19e-05	169	133	6	c8691c4f707d46b2865fe46eabe24ea4d03c7b43
ToppCell	droplet-Kidney-nan-3m-Epithelial-Pecam____kidney_capillary_endothelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NES SCARF2 OLFML2B SYNPO MRC2 ROBO2	1.31e-05	172	133	6	073a503dc922e3e3ac3528e249b0f8b74402110b
ToppCell	NS-moderate-d_07-13-Lymphoid-NK\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	NES ASPHD1 LRRC32 BCAN HACD1 MOCS1	1.45e-05	175	133	6	f6cd24d22f62469319f9d244e3e5de527d3d4d94
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Degenerative_Podocyte\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	NES APLP1 SYNPO PTPRO KCNH2 ROBO2	1.81e-05	182	133	6	cde8fa4f42d25545abaa9ee885b4b1e24a5a8e08
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_epithelium-respiratory_basal_cell-Basal_resting\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	COL7A1 ICAM4 ZFP36 NFATC3 TNS1 HACD1	1.86e-05	183	133	6	ec2af3402b51f11466d2a5783a6b33746b6a7fc9
ToppCell	Mesenchymal_cells-Osteoblasts\|Mesenchymal_cells / Lineage and Cell class	FAM110D ZNF469 SHC2 KCNH2 ROBO2 CREB3L3	1.86e-05	183	133	6	d6b52d52fe9a7a6c798947f05420d79fe12e4662
ToppCell	normal_Lung-Fibroblasts-Myofibroblasts\|normal_Lung / Location, Cell class and cell subclass	COL7A1 SCARF2 PTGER1 SSC5D ZNF469 ROBO2	1.92e-05	184	133	6	0b336489c10e8c3c957795dd845454f03404382b
ToppCell	3'_v3-lymph-node_spleen-Lymphocytic_Invariant-Inducer-like\|lymph-node_spleen / Manually curated celltypes from each tissue	PPP1R15A ZFP36 HOXA9 MRC2 PTCH2 TOX2	1.92e-05	184	133	6	d97471a4fe17cba6880ccf1a04cc00c741558124
ToppCell	droplet-Kidney-KIDNEY-1m-Epithelial-Pecam____kidney_capillary_endothelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SCARF2 OLFML2B SYNPO GPR88 MRC2 ROBO2	1.92e-05	184	133	6	1c857126c0ea0671f0d60b048efca288d348d653
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	NES APLP1 SYNPO PTPRO KCNH2 ROBO2	2.04e-05	186	133	6	1094c7140131454b2583200e1c01e81ccab3db23
ToppCell	10x_5'_v1-Non-neoplastic-Myeloid-Mono-Mono_anti-infl-Z\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	MRC1 ASPHD1 OLFML2B LPIN3 PTCH2 TNS1	2.04e-05	186	133	6	f73cb91e74a806858650ae97f543fc779ba4cff8
ToppCell	10x_5'_v1-Non-neoplastic-Myeloid-Mono-Mono_anti-infl\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	MRC1 ASPHD1 OLFML2B LPIN3 PTCH2 TNS1	2.04e-05	186	133	6	8694ca16c9780729f4fba67ba20e35745f1eb4e9
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Endothelial-endothelial_cell\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAM110D LRRC32 CARD10 SYNPO CDC42BPB RUSC2	2.11e-05	187	133	6	3548a9914c2b2f5d805798ce22ab26eab6d03897
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Endothelial-endothelial_cell\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAM110D LRRC32 CARD10 SYNPO CDC42BPB RUSC2	2.11e-05	187	133	6	f4de4b7af1fdfbd628b1f509c060c1079d2e5437
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Endothelial\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAM110D LRRC32 CARD10 SYNPO CDC42BPB RUSC2	2.11e-05	187	133	6	81754e965848b718be20ee97ce072ce426938a69
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Degenerative_Podocyte\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	NES APLP1 SYNPO PTPRO MRC2 ROBO2	2.17e-05	188	133	6	9db778c1d9e622a68337212296e3a1ed8f771fa5
ToppCell	TCGA-Breast-Primary_Tumor-Breast_Carcinoma-Infiltrating_Lobular_Carcinoma-6\|TCGA-Breast / Sample_Type by Project: Shred V9	SCARF2 FAM110D LRRC32 ZFP36 SSC5D PTCH2	2.17e-05	188	133	6	c90669b51e1902fe7726555290c91c92a911df83
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	NES APLP1 SYNPO PTPRO MRC2 ROBO2	2.17e-05	188	133	6	047c4e0b03fc8334e38c48977e41d26dbe229d47
ToppCell	Mesenchymal_cells-Osteoblasts\|World / Lineage and Cell class	FAM110D ZNF469 SHC2 KCNH2 ROBO2 CREB3L3	2.17e-05	188	133	6	89f7f5a51be7e046a63e2413f86c521ae4b6718f
ToppCell	droplet-Lung-30m-Hematologic-myeloid-alveolar_macrophage-alveolar_macrophage\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MRC1 LRP12 LIMA1 LY75 TNS1 HR	2.24e-05	189	133	6	98f517af255ef234eefc3ed7e6c1d63331ab8af0
ToppCell	droplet-Lung-30m-Hematologic-myeloid-alveolar_macrophage\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MRC1 LRP12 LIMA1 LY75 TNS1 HR	2.24e-05	189	133	6	f7e9b6e6a4de297b660a5b6c9a62f860c147185e
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Degenerative_Podocyte\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	NES COL7A1 APLP1 SYNPO PTPRO KCNH2	2.44e-05	192	133	6	ef0aba777072429a6ab7dcfcc305673975946580
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	NES COL7A1 APLP1 SYNPO PTPRO KCNH2	2.52e-05	193	133	6	3eaa0461618582a1754400624350d269d24e750a
ToppCell	droplet-Fat-Mat-18m-Endothelial\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DAB2IP FAM110D LRRC32 SYNPO KCNH2 TNS1	2.52e-05	193	133	6	54024a373e42e1c0bcc327dc084564b83b63a9d4
ToppCell	droplet-Fat-Mat-18m-Endothelial-endothelial_cell\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DAB2IP FAM110D LRRC32 SYNPO KCNH2 TNS1	2.52e-05	193	133	6	81d908594d2983ba7e7c1ec25afdde4315d9690e
ToppCell	COVID-19-kidney-FLT1+PLVAP+EC\|kidney / Disease (COVID-19 only), tissue and cell type	LRRC32 SYNPO PPP1R15A SHC2 TOX2 TNS1	2.52e-05	193	133	6	479abb1cd2eb978b8a4fdb900069a6329fc8cade
ToppCell	390C-Endothelial_cells-Endothelial-B_(Artery)\|390C / Donor, Lineage, Cell class and subclass (all cells)	NES LRRC32 ICAM4 SYNPO TMEM132A TOX2	2.59e-05	194	133	6	f8a59bd4609d147d8a706bf606e9e8173c9992a3
ToppCell	390C-Endothelial_cells-Endothelial-B_(Artery)-\|390C / Donor, Lineage, Cell class and subclass (all cells)	NES LRRC32 ICAM4 SYNPO TMEM132A TOX2	2.59e-05	194	133	6	04b1acc2e879feafb43f75435281c5acd8d23be2
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CTTNBP2 OLFML2B NLRP1 APLP1 SYNPO PTPRO	2.59e-05	194	133	6	1374600957c7d7f0b05fd2c1186f521b9096d4ef
ToppCell	droplet-Fat-Mat-18m-Endothelial-Cd36+\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DAB2IP FAM110D LRRC32 SYNPO KCNH2 TNS1	2.59e-05	194	133	6	74d0eaa76f6d9af14110dfe5b4bf9751b99ff6e3
ToppCell	Sepsis-ICU-SEP-Myeloid-cDC1\|ICU-SEP / Disease, condition lineage and cell class	LDLRAD2 SRPK1 PPP1R15A LPIN3 HOXA9 SLC9A7	2.82e-05	197	133	6	e3174e90ea6136f1aa3a4a185b86458e35d51fd4
ToppCell	(1)_T_cell-(15)_Treg\|(1)_T_cell / shred on Cell_type and subtype	MRC1 LIMA1 LRRC32 IFNAR2 TOX2 HACD1	2.82e-05	197	133	6	6e7723e8b977be35c60cc11ac7cfa4f71339441e
ToppCell	Transverse-T_cell-Treg\|T_cell / Region, Cell class and subclass	LIMA1 LRRC32 OPRM1 GDF7 TOX2 HACD1	2.82e-05	197	133	6	b7a1637e4baadd657f6279f4aa96cd590c9cd8c9
ToppCell	Sigmoid-T_cell-Treg\|T_cell / Region, Cell class and subclass	MRC1 LIMA1 OPRM1 GDF7 TOX2 HACD1	2.90e-05	198	133	6	e2d2f9f209f77d0c48cfe3e9902c0ae0795511b2
ToppCell	wk_08-11-Mesenchymal-Myofibro_&_SMC-Pericyte\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	NES OLFML2B LRRC32 PLEKHH3 TNS1 MOCS1	2.90e-05	198	133	6	72aad5b2dcd8b0bde58828fa4f8129fe6cb6a21d
ToppCell	Parenchymal-10x3prime_v2-Stromal-Myofibroblastic-Muscle_smooth_airway_ASM\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	LRP12 KSR1 SSC5D RPAP1 KCNH2 SPOCD1	2.90e-05	198	133	6	cc2b5b632e73e44bb60050f0db10d8f0dbb859fa
ToppCell	Parenchymal-10x5prime-Epithelial-Epi_airway_neuro-secretory-Neuroendocrine\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	ASPHD1 APLP1 NACAD RNF39 MEX3B INPP5J	2.90e-05	198	133	6	d6812494874be0c14361ac2ac3e418b335bb8f55
ToppCell	PSB-critical-LOC-Epithelial-Basal\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	COL7A1 ICAM4 PLEKHH3 TMEM132A TNS1 HACD1	2.99e-05	199	133	6	2add64c3e4cb6384ec381f34c3f1f77e13e3f27c
ToppCell	Sepsis-Bac-SEP-Myeloid-cDC1\|Bac-SEP / Disease, condition lineage and cell class	LIMA1 LPIN3 HOXA9 GDF7 MRC2 SLC9A7	3.07e-05	200	133	6	cd381644fd8b8674a017d267bfbb00f2668294ae
ToppCell	Parenchymal-10x5prime-Stromal-Fibroblastic-Fibro_myofibroblast\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	COL7A1 OLFML2B PTGER1 SSC5D MRC2 ROBO2	3.07e-05	200	133	6	54806080b5e97859ee6a4a9b4f19e22021c218f5
ToppCell	PBMC-Control-Lymphocyte-T/NK-CD4+_T-Treg-Treg_2\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SCARF2 SRPK1 PLEKHH3 KCNH2 HACD1	4.46e-05	130	133	5	0f9d3e6297f48ae14d24ac997d8d3a94f337d4d4
ToppCell	PBMC-Control-Lymphocyte-T/NK-CD4+_T-Treg-Treg_2\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	SCARF2 SRPK1 PLEKHH3 KCNH2 HACD1	4.46e-05	130	133	5	fc68a648161dd314d9ee6612fd039cb12171b8c6
ToppCell	Frontal_cortex-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	KCNH2 TNRC6A TOX2 ALK INPP5J	7.49e-05	145	133	5	8b13b576fd2e6e33ccb146860a91a53cee0cdd4d
ToppCell	TCGA-Breast-Primary_Tumor-Breast_Carcinoma-Mucinous_Carcinoma-1\|TCGA-Breast / Sample_Type by Project: Shred V9	ASPHD1 APLP1 KCNH2 ROBO2 DLEC1	8.51e-05	149	133	5	649eb3441fa859591ea85f1ed5fcf08af272a32b
ToppCell	3'-Child09-12-SmallIntestine-Hematopoietic-B_cells-STAT1+_Naive_B\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	APLP1 PLEKHH3 PHF1 PTPRO RELT	9.35e-05	152	133	5	dd728aa3ffdb2c415730a62678f69cf0e8af09df
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c08-GZMK-FOS_h\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	ZNF219 SCARF2 OPRM1 ZNF41 ZNF513	9.35e-05	152	133	5	6aad62b5b5ad2f78c6600f37960338d40628a439
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Degenerative_Podocyte\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	NES APLP1 SYNPO ZNF469 PTPRO	9.64e-05	153	133	5	c1335e7d7407412431ed4d8c7dfcb2c6086d8483
ToppCell	PBMC-Severe-cDC_1\|Severe / Compartment, Disease Groups and Clusters	NLRP1 SYNPO TMEM132A MOCS1	1.02e-04	81	133	4	6d1e524f000b71c935359afc801a1d31f218fec8
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell__prolif\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DAB2IP TICRR LRRC32 MAMSTR TOX2	1.03e-04	155	133	5	59035d792c26d870a8b097939e97fa47859ba68c
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-1M-Radial_glial-gliogenic/outer_RGCs_and_astrocytes\|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.	LIMA1 OLFML2B IGSF5 BCAN AGBL3	1.09e-04	157	133	5	2c1219ee19a6246a3b9f5c2c1a37f26ea934a822
ToppCell	PBMC-Severe-Myeloid-cDC-cDC-cDC_4\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	MRC1 ZNF219 OLFML2B HOXA9 SLC9A7	1.09e-04	157	133	5	f896997490bb2eec598c6581f161220e70f9a991
ToppCell	PBMC-Severe-Myeloid-cDC-cDC-cDC_4\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	MRC1 ZNF219 OLFML2B HOXA9 SLC9A7	1.09e-04	157	133	5	14a8516346a89a89f1119b744625bd9844a74a03
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_epithelium-respiratory_basal_cell-Basal_resting-Basal_resting_L.0.0.0.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ASPHD1 TMEM79 ICAM4 PPP1R15A ZFP36	1.23e-04	161	133	5	0d863d7d369391dd6148e1de6d6f8033dcb8fe0f
ToppCell	severe_influenza-cDC\|severe_influenza / disease group, cell group and cell class (v2)	CNKSR1 CTTNBP2 RGS12 HOXA9 HACD1	1.23e-04	161	133	5	7716315b8bda904b346cea47edc2c0b507a345c2
ToppCell	PBMC-Control-Myeloid-cDC-cDC-cDC_11\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	LIMA1 LDLRAD2 HOXA9 MRC2 SLC9A7	1.30e-04	163	133	5	a09449a502627aa369db600dba5bda93de7ce5c0
ToppCell	5'-Adult-Appendix-Hematopoietic-T_cells-ILC3\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	IGSF5 HOXA9 SLC9A7 TOX2 MEX3B	1.30e-04	163	133	5	00e791358a7eb6c3e95f87afe22153845012e4a1
ToppCell	PBMC-Control-Myeloid-cDC-cDC-cDC_11\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	LIMA1 LDLRAD2 HOXA9 MRC2 SLC9A7	1.34e-04	164	133	5	ed888b55d9c685096fd785878fcb264f4fee88d6
ToppCell	PND01-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_B-B-B_prolif\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SPN PPRC1 ZNF692 FCHO1 CD19	1.37e-04	165	133	5	66f0364098d82629aa2ec1dfe0c5ad23de7c2c12
ToppCell	356C-Fibroblasts-Fibroblast-D\|356C / Donor, Lineage, Cell class and subclass (all cells)	COL7A1 SCARF2 SHC2 PRR19 HR	1.41e-04	166	133	5	7286a37b2827f3747469ffd0d76cbe81116db7ee
ToppCell	remission-HSPC\|World / disease stage, cell group and cell class	ICAM4 HOXA9 KCNH2 MEX3B HACD1	1.41e-04	166	133	5	d269ee6f7adb55b05dcb5eaea96629ccb0b2d6e3
ToppCell	Influenza_Severe-cDC\|Influenza_Severe / Disease group and Cell class	CNKSR1 CTTNBP2 RGS12 KCNH2 SLC9A7	1.41e-04	166	133	5	b40bdf0f7f381e25be61188e9f6c294d25a8b824
ToppCell	facs-Brain_Non-Myeloid-Striatum-3m-Neuronal-neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VWA5B2 OPRM1 TH DLEC1 TOX2	1.41e-04	166	133	5	548d0d6c0ffd564036ddba78620734220ebb73d7
ToppCell	facs-Brain_Non-Myeloid-Striatum-3m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VWA5B2 OPRM1 TH DLEC1 TOX2	1.41e-04	166	133	5	80e164a89d22098cabe4a99a78283ba69ea0561e
ToppCell	356C-Fibroblasts-Fibroblast-D-\|356C / Donor, Lineage, Cell class and subclass (all cells)	COL7A1 SCARF2 SHC2 PRR19 HR	1.41e-04	166	133	5	7c2eee0a4f45795a956acf936b85bdb35f1b1624
ToppCell	367C-Lymphocytic-NK_cells-NK_cell_E\|NK_cells / Donor, Lineage, Cell class and subclass (all cells)	NACAD RUSC2 LPIN3 PTPRO MRC2	1.45e-04	167	133	5	b5d15773be32cd277125fd3b4056a8fefaefa5ec
ToppCell	368C-Myeloid-Dendritic-pDC\|368C / Donor, Lineage, Cell class and subclass (all cells)	IFNAR2 ZNF469 RPAP1 RELT SNTA1	1.45e-04	167	133	5	1e2fc1637769405a61f4c7e44945712a1888a299
ToppCell	TCGA-Mesothelium-Primary_Tumor-Mesothelioma-Biphasic\|TCGA-Mesothelium / Sample_Type by Project: Shred V9	NES SCARF2 OLFML2B TH ZNF469	1.45e-04	167	133	5	9062577a4b7902c9a888d706589d1b05221c0fa8
ToppCell	TCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Squamous_Cell_Carcinoma-4\|TCGA-Lung / Sample_Type by Project: Shred V9	OLFML2B PTGER1 SSC5D ZNF469 MRC2	1.49e-04	168	133	5	aefea14b8b1c1b6a05f827effd22ba15274fddc9
ToppCell	390C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_5\|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)	MRC1 LRP12 ICAM4 BCL9 SPOCD1	1.49e-04	168	133	5	d7d19c93d1c3dd994e18e28d5f36ae7773ff5d7f
ToppCell	3'_v3-bone_marrow-Myeloid_Mac-Intermediate_macrophages\|bone_marrow / Manually curated celltypes from each tissue	MRC1 ASPHD1 SPOCD1 TNS1 MEX3B	1.49e-04	168	133	5	8ade4d098aeecda2d80c1cad1cebe9a063eae948
ToppCell	wk_15-18-Hematologic-Myeloid-CMP\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	LDLRAD2 SPN HOXA9 CREB3L3 INPP5J	1.49e-04	168	133	5	9fc9c93ab7513bf4dfefc866b97c703208a238c9
ToppCell	390C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_5\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	MRC1 LRP12 ICAM4 BCL9 SPOCD1	1.54e-04	169	133	5	d2def7229fe9d6b0c70cfed349ede491c8c137a0
ToppCell	wk_08-11-Mesenchymal-Myofibro_&_SMC-Myofibro_2\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	IRAK1 GRM2 HOXA9 ROBO2 ZNF513	1.58e-04	170	133	5	fefb07a7e308b620f946b9ff2b01e1796446fe38
ToppCell	COVID-19_Convalescent-Hematopoietic_SC\|COVID-19_Convalescent / Disease group, lineage and cell class	ICAM4 HOXA9 KCNH2 MEX3B HACD1	1.58e-04	170	133	5	8a73d5334eed1cd9fdcc3ebeae0bdf9f945c228a
ToppCell	E18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-PMP-PMP_prolif\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SCARF2 SHC2 SLBP USP54 C4orf46	1.58e-04	170	133	5	b1a16600754e0c12f7d39c9221f1b03135833f16
ToppCell	PBMC-Convalescent-Hematopoietic-HSPC-HSPC\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ICAM4 HOXA9 KCNH2 MEX3B HACD1	1.62e-04	171	133	5	2031797d579ce373921affad70da6e50eec13664
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Degenerative_Podocyte\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	NES SYNPO KIAA1191 PTPRO C4orf46	1.62e-04	171	133	5	f047a0cc2ce0a062ec502aa9cb91b1202f437f29
ToppCell	facs-Marrow-T-cells-3m-Myeloid-granulocytopoietic_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TICRR LRP12 PTCH2 HCFC2 LY75	1.62e-04	171	133	5	913bae728b5e653771a27c79a309eb023699f1d0
ToppCell	remission-HSPC\|remission / disease stage, cell group and cell class	ICAM4 HOXA9 KCNH2 MEX3B HACD1	1.62e-04	171	133	5	41b424e58470a2fc25632aea50a37c7c5ea17645
ToppCell	facs-Marrow-T-cells-3m-Myeloid-granulocytopoietic_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TICRR LRP12 PTCH2 HCFC2 LY75	1.62e-04	171	133	5	f28b2336057e353b96a6ff4581ec9fd0ca0789d9
ToppCell	PBMC-Convalescent-Hematopoietic-HSPC-HSPC-\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ICAM4 HOXA9 KCNH2 MEX3B HACD1	1.62e-04	171	133	5	a4e13b304ef414722ffdc06560deeab41785e956
ToppCell	PBMC-Convalescent-Hematopoietic-HSPC\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ICAM4 HOXA9 KCNH2 MEX3B HACD1	1.62e-04	171	133	5	172db31a37b72fb87fe5f0f79da51866b90dd1ad
ToppCell	Thalamus-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1-Endothelial_Tip.Dcn_(Dcn)\|Thalamus / BrainAtlas - Mouse McCarroll V32	NLRP1 LPIN3 CBY3 MRC2	1.67e-04	92	133	4	bbaf5a131f860198840e34843b7c841bcc98d9c4
ToppCell	Thalamus-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1-Endothelial_Tip.Dcn_(Dcn)-\|Thalamus / BrainAtlas - Mouse McCarroll V32	NLRP1 LPIN3 CBY3 MRC2	1.67e-04	92	133	4	e6aa2b8ca9235a7291ee41d976b886fec185835d
ToppCell	PBMC-Convalescent-Hematopoietic-HSPC-HSPC-\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	ICAM4 HOXA9 KCNH2 MEX3B HACD1	1.67e-04	172	133	5	8fd3db757d54949bd583d5f0eadf63a32342cb9d
ToppCell	5'-GW_trimst-2-SmallIntestine-Hematopoietic-B_cells-CLP\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	LDLRAD2 SPN HOXA9 GAB4 TOX2	1.67e-04	172	133	5	37ff83f53e99df62691d078ca6801b2c0ec2b123
Drug	Methylprednisolone, 6-alpha [83-43-2]; Up 200; 10.6uM; MCF7; HT_HG-U133A	LRP12 OLFML2B BCAN ZNF446 RUSC2 KSR1 MRC2 TBX10 TNS1 SNTA1 HR	1.73e-08	196	130	11	6785_UP
Drug	S(+)-Terguride [37686-84-3]; Down 200; 11.8uM; PC3; HT_HG-U133A	TRPM4 DDX31 FPGS ZNF692 ZYX ZFP36 RUSC2 NFATC3 TMEM132A TNS1	1.93e-07	196	130	10	6299_DN
Drug	Cefotaxime sodium salt [64485-93-4]; Down 200; 8.4uM; PC3; HT_HG-U133A	TRPM4 LRP12 CNKSR1 SPN ZNF446 SMG7 RPAP1 NFATC3 CABIN1	1.94e-06	196	130	9	5830_DN
Drug	3-alpha-Hydroxy-5-beta-androstan-17-one [53-42-9]; Up 200; 13.8uM; MCF7; HT_HG-U133A	BRME1 SYNPO ZNF446 RGS12 PHF1 HOXA9 NEUROG1 KCNH2 HR	2.02e-06	197	130	9	3639_UP
Drug	Acebutolol hydrochloride [34381-68-5]; Up 200; 10.8uM; MCF7; HT_HG-U133A	LRP12 OPRM1 RUSC2 TH KCNH2 CABIN1 ALK SNTA1 MOCS1	2.11e-06	198	130	9	1493_UP
Drug	Ampyrone [83-07-8]; Down 200; 19.6uM; MCF7; HT_HG-U133A	CNKSR1 ASPHD1 SPN ICAM4 PPP1R15A RGS12 HOXA9 TBX10	1.67e-05	195	130	8	6845_DN
Drug	Palmatine chloride [3486-67-7]; Up 200; 10.4uM; MCF7; HT_HG-U133A	APLP1 ZYX RGS12 RPAP1 SLC9A7 CABIN1 ALK MOCS1	1.67e-05	195	130	8	2795_UP
Drug	5140203; Down 200; 15uM; MCF7; HT_HG-U133A_EA	LRP12 CNKSR1 ZDHHC18 ZNF219 FCHO1 IFNAR2 SMG7 CABIN1	1.67e-05	195	130	8	908_DN
Drug	Acacetin [480-44-4]; Down 200; 14uM; PC3; HT_HG-U133A	TRIO SPN APLP1 PPP1R15A ZNF446 PHF1 CABIN1 MOCS1	1.67e-05	195	130	8	4324_DN
Drug	Lomefloxacin hydrochloride [98079-52-8]; Up 200; 10.4uM; MCF7; HT_HG-U133A	TRIO DYRK1A BRME1 ZNF446 SMG7 MRC2 PTCH2 HR	1.67e-05	195	130	8	3620_UP
Drug	Clofilium tosylate [92953-10-1]; Down 200; 7.8uM; MCF7; HT_HG-U133A	NES TRPM4 DDX31 ZNF446 ZYX TH KCNH2 HR	1.73e-05	196	130	8	3187_DN
Drug	prochlorperazine dimaleate salt; Down 200; 10uM; PC3; HT_HG-U133A	ASPHD1 OLFML2B NLRP1 BCAN RGS12 SMG7 TNS1 ALK	1.73e-05	196	130	8	4439_DN
Drug	Lovastatin [75330-75-5]; Up 200; 9.8uM; PC3; HT_HG-U133A	ICAM4 NLRP1 SMG7 NFATC3 SLC9A7 TNS1 ALK HR	1.73e-05	196	130	8	6633_UP
Drug	Napelline [5008-52-6]; Up 200; 11.2uM; MCF7; HT_HG-U133A	APLP1 BCAN RUSC2 SHC2 NFATC3 SNTA1 MOCS1 HR	1.73e-05	196	130	8	6824_UP
Drug	Cefamandole sodium salt [30034-03-8]; Down 200; 8.2uM; MCF7; HT_HG-U133A	ZNF219 SPN RUSC2 RPAP1 TBX10 HCFC2 SNTA1 HR	1.73e-05	196	130	8	4718_DN
Drug	Orphenadrine hydrochloride [341-69-5]; Down 200; 13uM; PC3; HT_HG-U133A	ASPHD1 TRIO OLFML2B ZNF446 TH TNS1 ALK HR	1.80e-05	197	130	8	3801_DN
Drug	Cyclacillin [3485-14-1]; Down 200; 11.8uM; PC3; HT_HG-U133A	TRPM4 ZNF219 TRIO BCAN ZNF446 TNS1 ALK HR	1.80e-05	197	130	8	3800_DN
Drug	Nitrarine dihydrochloride [20069-05-0]; Up 200; 10.6uM; MCF7; HT_HG-U133A	SPN SYNPO ZNF446 RUSC2 KSR1 TNS1 SNTA1 HR	1.80e-05	197	130	8	6043_UP
Drug	Minaprine dihydrochloride [25953-17-7]; Down 200; 10.8uM; MCF7; HT_HG-U133A	ZNF219 SPN ZNF446 ZYX SMG7 NFATC3 CABIN1 MOCS1	1.80e-05	197	130	8	4814_DN
Drug	alpha-Santonin [481-06-1]; Down 200; 16.2uM; MCF7; HT_HG-U133A	COL7A1 LRP12 MIA3 SPN RGS12 PHF1 ALK SNTA1	1.86e-05	198	130	8	4353_DN
Drug	fullerene C60	VWA5B2 TRPM4 COL7A1 ZNF219 TRIO PPRC1 ENTR1 SRPK1 CARD10 PPP1R15A PTGER1 IL22RA1 CDC42BPB RGS12 ZFP36 PRKAG3 GDF7 CD19 PTCH2 TNS1 SNTA1 MOCS1	3.87e-05	1498	130	22	ctd:C069837
Drug	S-312-d	APLP1 CABIN1	9.67e-05	3	130	2	CID000129003
Drug	LY294002; Down 200; 10uM; MCF7; HT_HG-U133A	DDX31 PPRC1 ZYX NFATC3 KCNH2 ALK INPP5J	1.24e-04	193	130	7	5965_DN
Drug	Leflunomide [75706-12-6]; Up 200; 14.8uM; MCF7; HT_HG-U133A	RGS12 AGBL3 KCNH2 SLC9A7 ALK SNTA1 MOCS1	1.28e-04	194	130	7	6102_UP
Drug	Protriptyline hydrochloride [1225-55-4]; Down 200; 13.4uM; PC3; HT_HG-U133A	LRP12 SPN FPGS SYNPO BCL9 TH CABIN1	1.32e-04	195	130	7	6338_DN
Drug	Rapamycin; Down 200; 0.1uM; PC3; HT_HG-U133A	CNKSR1 ZDHHC18 BCL9 SMG7 RPAP1 NFATC3 SNTA1	1.32e-04	195	130	7	1207_DN
Drug	Scopoletin [92-61-5]; Down 200; 20.8uM; MCF7; HT_HG-U133A	TRPM4 CNKSR1 ASPHD1 APLP1 PPP1R15A RGS12 SMG7	1.32e-04	195	130	7	6510_DN
Drug	Etifenin [63245-28-3]; Down 200; 12.4uM; MCF7; HT_HG-U133A	ZNF219 ZNF446 RGS12 RUSC2 KCNH2 TBX10 INPP5J	1.32e-04	195	130	7	4117_DN
Drug	Mephentermine hemisulfate [1212-72-2]; Down 200; 9.4uM; MCF7; HT_HG-U133A	TRPM4 ASPHD1 RGS12 RUSC2 HCFC2 MOCS1 HR	1.32e-04	195	130	7	4707_DN
Drug	Diphenidol hydrochloride [3254-89-5]; Up 200; 11.6uM; MCF7; HT_HG-U133A	TRPM4 ASPHD1 PPP1R15A RGS12 TH SHC2 ALK	1.32e-04	195	130	7	7406_UP
Drug	Tiapride hydrochloride [51012-33-0]; Down 200; 11uM; MCF7; HT_HG-U133A	TRIO PPP1R15A RGS12 RUSC2 TBX10 SNTA1 HR	1.32e-04	195	130	7	4686_DN
Drug	Alfadolone acetate [23930-37-2]; Down 200; 10.2uM; MCF7; HT_HG-U133A	LRP12 APLP1 ZNF446 IFNAR2 NFATC3 KCNH2 CABIN1	1.36e-04	196	130	7	6506_DN
Drug	Azapropazone [13539-59-8]; Down 200; 13.4uM; PC3; HT_HG-U133A	TRPM4 CNKSR1 PPP1R15A FCHO1 RPAP1 TMEM132A TNS1	1.36e-04	196	130	7	7277_DN
Drug	Benzonatate [104-31-4]; Down 200; 6.6uM; MCF7; HT_HG-U133A	NES MIA3 ASPHD1 BCL9 ZNF446 TH INPP5J	1.36e-04	196	130	7	5435_DN
Drug	Aspartic acid, N-acetyl (R,S) [997-55-7]; Down 200; 22.8uM; MCF7; HT_HG-U133A	LRP12 PPP1R15A BCL9 RGS12 RUSC2 CABIN1 HR	1.36e-04	196	130	7	4125_DN
Drug	Condelphine [7633-69-4]; Down 200; 8.8uM; PC3; HT_HG-U133A	COL7A1 CNKSR1 ZDHHC18 FPGS APLP1 NFATC3 MOCS1	1.36e-04	196	130	7	6357_DN
Drug	wortmannin from Penicillium funiculosum; Down 200; 0.01uM; PC3; HT_HG-U133A	ZNF219 SPN OLFML2B NLRP1 TNS1 INPP5J HR	1.36e-04	196	130	7	4467_DN
Drug	3-Acetylcoumarin [3949-36-8]; Down 200; 21.2uM; MCF7; HT_HG-U133A	COL7A1 LRP12 TRIO BCAN RGS12 TNS1 SNTA1	1.36e-04	196	130	7	5624_DN
Drug	Pyrantel tartrate [33401-94-4]; Down 200; 11.2uM; MCF7; HT_HG-U133A	COL7A1 ZNF219 BCAN SMG7 TBX10 SNTA1 INPP5J	1.41e-04	197	130	7	2260_DN
Drug	CP-320650-01 [172079-28-6]; Down 200; 10uM; PC3; HT_HG-U133A	DDX31 SPN BCL9 ZNF446 MRC2 TMEM132A TNS1	1.41e-04	197	130	7	4557_DN
Drug	Lisuride (S)(-) [18016-80-3]; Down 200; 11.8uM; MCF7; HT_HG-U133A	COL7A1 LRP12 DYRK1A APLP1 RUSC2 HOXA9 HCFC2	1.41e-04	197	130	7	1545_DN
Drug	Guanadrel sulfate [22195-34-2]; Up 200; 7.6uM; PC3; HT_HG-U133A	RGS12 KSR1 KCNH2 MRC2 PTCH2 SLC9A7 HR	1.41e-04	197	130	7	3698_UP
Drug	Phenazopyridine hydrochloride [136-40-3]; Down 200; 16uM; MCF7; HT_HG-U133A	TRPM4 ZYX RGS12 OPRM1 RUSC2 HOXA9 NFATC3	1.41e-04	197	130	7	6100_DN
Drug	Pirenperone [ 75444-65-4]; Up 200; 10.2uM; MCF7; HT_HG-U133A	TRIO ICAM4 APLP1 ZNF446 PTCH2 TBX10 CABIN1	1.41e-04	197	130	7	3316_UP
Drug	LY 294002; Down 200; 10uM; MCF7; HT_HG-U133A	NES DDX31 TRIO ZNF446 TH RPAP1 KCNH2	1.41e-04	197	130	7	5236_DN
Drug	Norgestrel-(-)-D [797-63-7]; Down 200; 12.8uM; PC3; HT_HG-U133A	COL7A1 TRIO ZNF446 SMG7 SLC9A7 CABIN1 HR	1.41e-04	197	130	7	3708_DN
Drug	Diltiazem hydrochloride [33286-22-5]; Up 200; 8.8uM; PC3; HG-U133A	SYNPO BCL9 PTGER1 ZYX RUSC2 SMG7 ALK	1.41e-04	197	130	7	1948_UP
Drug	11-deoxy-16,16-dimethyl Prostaglandin E2; Down 200; 10uM; MCF7; HT_HG-U133A	COL7A1 ZNF219 TRIO RGS12 RUSC2 PHF1 MOCS1	1.45e-04	198	130	7	7514_DN
Drug	Dilazep dihydrochloride [20153-98-4]; Up 200; 6uM; MCF7; HT_HG-U133A	COL7A1 SPN OLFML2B NLRP1 APLP1 PTCH2 TNS1	1.45e-04	198	130	7	2294_UP
Drug	Yohimbine hydrochloride [65-19-0]; Up 200; 10.2uM; MCF7; HT_HG-U133A	LRP12 RGS12 NFATC3 PTPRO SLC9A7 SNTA1 INPP5J	1.45e-04	198	130	7	6777_UP
Drug	Delcorine; Up 200; 8.4uM; MCF7; HT_HG-U133A	APLP1 RGS12 RUSC2 HOXA9 TNS1 SNTA1 MOCS1	1.45e-04	198	130	7	6033_UP
Drug	Mebendazole [31431-39-7]; Up 200; 13.6uM; PC3; HT_HG-U133A	DDX31 TRIO DYRK1A RGS12 OPRM1 TNS1 HR	1.45e-04	198	130	7	3671_UP
Drug	Tetramisole hydrochloride [16595-80-5]; Up 200; 16.6uM; MCF7; HT_HG-U133A	ICAM4 BCAN HOXA9 KSR1 CD19 TNS1 ALK	1.45e-04	198	130	7	4412_UP
Drug	Oxaprozin [21256-18-8]; Down 200; 13.6uM; MCF7; HT_HG-U133A	LRP12 MIA3 ASPHD1 SPN ALK SNTA1 MOCS1	1.50e-04	199	130	7	4352_DN
Drug	wortmannin; Down 200; 0.01uM; ssMCF7; HG-U133A	NES COL7A1 PPRC1 ZNF446 ZFP36 NFATC3 DLEC1	1.50e-04	199	130	7	404_DN
Drug	Ungerine nitrate; Up 200; 10.2uM; MCF7; HT_HG-U133A	LRRC32 RGS12 KCNH2 SLC9A7 ALK SNTA1 HR	1.50e-04	199	130	7	6076_UP
Drug	Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; MCF7; HT_HG-U133A	LRP12 DYRK1A RGS12 PLEKHH3 RUSC2 PHF1 TNS1	1.50e-04	199	130	7	3872_UP
Drug	Podophyllotoxin [518-28-5]; Down 200; 9.6uM; PC3; HT_HG-U133A	TRPM4 FPGS BCL9 ZNF692 FCHO1 ZNF446 SNTA1	1.50e-04	199	130	7	5841_DN
Drug	Desipramine	NES PPP1R15A TH KCNH2	1.50e-04	47	130	4	ctd:D003891
Drug	Famprofazone [22881-35-2]; Up 200; 10.6uM; MCF7; HT_HG-U133A	COL7A1 DYRK1A GRM2 RGS12 TNS1 MOCS1 HR	1.54e-04	200	130	7	6029_UP
Drug	Tropicamide [1508-75-4]; Up 200; 14uM; MCF7; HT_HG-U133A	COL7A1 SYNPO RUSC2 PHF1 KCNH2 SLC9A7 HR	1.54e-04	200	130	7	3619_UP
Drug	aceperone	TRIO TH	1.93e-04	4	130	2	CID000013122
Drug	POPOP	TRIO NLRP1	1.93e-04	4	130	2	CID000015732
Drug	Methadyl Acetate	OPRM1 KCNH2	1.93e-04	4	130	2	ctd:D008692
Disease	brain ischemia (biomarker_via_orthology)	NES IRAK1 PPP1R15A OPRM1 TH	8.76e-05	102	129	5	DOID:2316 (biomarker_via_orthology)
Disease	long QT syndrome (is_implicated_in)	KCNH2 SNTA1	3.93e-04	7	129	2	DOID:2843 (is_implicated_in)
Disease	thioredoxin domain-containing protein 12 measurement	COL7A1 GRM2 SCAP	6.65e-04	39	129	3	EFO_0008298
Disease	margarate 17:0 measurement	GPR88 ALK	6.69e-04	9	129	2	EFO_0021066
Disease	serum gamma-glutamyl transferase measurement	ZDHHC18 PCNX3 FAM53A DYRK1A IRAK1 NLRP1 CDC42BPB FCHO1 ZYX SLC9A7 SLBP CABIN1	6.90e-04	914	129	12	EFO_0004532
Disease	Congenital long QT syndrome	KCNH2 SNTA1	1.02e-03	11	129	2	cv:C1141890
Disease	Long QT syndrome	KCNH2 SNTA1	1.22e-03	12	129	2	cv:C0023976
Disease	neuroimaging measurement, brain volume measurement	MRC1 CTTNBP2 ASPHD1 POLR2M ITPRID1 PROSER3	1.65e-03	286	129	6	EFO_0004346, EFO_0006930
Disease	T wave morphology measurement	OLFML2B KCNH2	1.67e-03	14	129	2	EFO_0008398
Disease	von Willebrand factor measurement, coronary artery disease	DAB2IP MIA3 DDX31 FCHO1	1.82e-03	118	129	4	EFO_0001645, EFO_0004629
Disease	Alopecia, Male Pattern	ZFP36 HR	1.92e-03	15	129	2	C4083212
Disease	Androgenetic Alopecia	ZFP36 HR	1.92e-03	15	129	2	C0162311
Disease	Female pattern alopecia (disorder)	ZFP36 HR	1.92e-03	15	129	2	C0263477
Disease	Romano-Ward Syndrome	KCNH2 SNTA1	2.19e-03	16	129	2	C0035828
Disease	Psychoses, Substance-Induced	GRM2 OPRM1	2.47e-03	17	129	2	C0033941
Disease	Pseudopelade	ZFP36 HR	3.09e-03	19	129	2	C0086873
Disease	Alopecia	ZFP36 HR	3.09e-03	19	129	2	C0002170
Disease	response to methotrexate, neurotoxicity	DAB2IP TLX1NB	3.09e-03	19	129	2	EFO_0011057, GO_0031427
Disease	Psychoses, Drug	GRM2 OPRM1	3.77e-03	21	129	2	C0033937
Disease	Ovarian Failure, Premature	SOHLH1 NOBOX	3.77e-03	21	129	2	C0085215

Protein segments in the cluster

Peptide	Gene	Start	Entry
YGVSSSGPLSPTRWP	AGBL3	76	Q8NEM8
TWSLSEFPSPLGGPE	CARD10	476	Q9BWT7
LTSPSGTILSPGWPG	CSMD2	756	Q7Z408
SILGSGDSLPSSPLW	CREB3L3	66	Q68CJ9
GDSLPSSPLWSPEGS	CREB3L3	71	Q68CJ9
GVGTPPTGWDCLPSD	PRKAG3	106	Q9UGI9
SAASSPGGPVSLGWP	C4orf46	26	Q504U0
FWDDPPSAFPSGLGS	FAM220BP	161	B1ANY3
DTSLIPWASPSAGPL	GRM2	481	Q14416
TAVGDPSTRSWPPGS	APLP1	221	P51693
QFPAPLGWSGTEAPT	DYRK1A	561	Q13627
AAPPGSPSSFWTSGL	CBY3	16	A6NI87
LAPPPTSASGASRSW	KIRREL3-AS3	126	Q8N7Y1
DGPCGSWGTSITLPP	NOBOX	481	O60393
AWPSELSSPGPEASL	BCAN	481	Q96GW7
PRPSSGTLASASPDW	DAB2IP	946	Q5VWQ8
PLASSPGPWGLEALA	FCHO1	526	O14526
RLSASWEPLSGPSTP	FCHO1	831	O14526
SPIPWGGLSGFPSDS	LPIN3	106	Q9BQK8
SCSPAPSPGSWVNLS	OPRM1	21	P35372
PSPALGSAGSLWIAA	LDLRAD2	236	Q5SZI1
LGLLPTGSAEPPADW	GPR88	91	Q9GZN0
EGIHLSWEPPTSPSG	HCFC2	691	Q9Y5Z7
APSGIITSPGWPSEY	LRP12	56	Q9Y561
AWPPPTELGSSGSAL	LIMA1	531	Q9UHB6
PPSPASDAESWGSGA	NEUROG1	176	Q92886
SWSSPKPIGPLTDLG	ERVS71-1	231	P61550
SPSSSAWAKLGPTPL	ITPRID1	1016	Q6ZRS4
PLWTSIGASTGSPLP	SPN	76	P16150
AVSWDFSGTTPPPRG	ASPHD1	226	Q5U4P2
PWGESPSSGPSSPES	KCNH2	926	Q12809
PPQPSSLGSTTFWEG	HR	906	O43593
EPSPLAGDGAPWSGS	PCNX3	216	Q9H6A9
LSAASLPWPPGSSQL	KSR1	201	Q8IVT5
PAGLGLTPSAWEASS	PTGER1	376	P34995
APTSTAVLGSWGSPP	NLRP1	176	Q9C000
WLEPTPGALSFAGLP	HOXA9	111	P31269
TLGHTGSDAPSPWPL	NES	1191	P48681
GSDAPSPWPLGSEEA	NES	1196	P48681
NWDPDRPSAPTIGGS	LY75	301	O60449
PTPSLTGSCPQGWAS	MRC2	661	Q9UBG0
WPSSGGSEPSVTVPL	CDC42BPB	1641	Q9Y5S2
WFTSGSSTALPGPNP	KIAA1191	191	Q96A73
APLGTSPYSWSRSGP	DDX31	56	Q9H8H2
SGAAPWQPLAAPSGA	IRAK1	556	P51617
CLSPGSWASAAPSGP	MOCS1	461	Q9NZB8
ESPAPGPGLAGWSHL	FAM182B	91	Q5T319
GTQPTFPSPSSEGLW	IFNAR2	476	P48551
TPEIPSGNISSGWPD	PTPRO	271	Q16827
GWSALPLSAPSGNAS	LRRC32	296	Q14392
WSALPSSAGPSPGPF	MAML2	461	Q8IZL2
LSSLPSLGFSLPTWG	IGSF5	251	Q9NSI5
SGPAPGLGPASWCLE	BRME1	286	Q0VDD7
IPGKPSASTPTLWDG	CABIN1	1466	Q9Y6J0
RVSWGPAESPPGSFS	POLR2M	76	Q6EEV4
APGSTLWLSCGVPPD	CD19	191	P15391
WSPSLTPLLMSGGPA	CTTNBP2	691	Q8WZ74
STPSELAGPESLPSW	ENTR1	216	Q96C92
PLSSWPGSGPAGGST	GAB4	21	Q2WGN9
PASRPGLSGVSWPDD	BCL9	581	O00512
AAGWAGSPPTLLPLS	HACD1	16	B0YJ81
SSPWASGEKPPAGSE	DIDO1	1616	Q9BTC0
SALGPPGPSLWEGTD	MAMSTR	121	Q6ZN01
SPSDQGPSPWGLLES	IL22RA1	521	Q8N6P7
LWSAPSPEPGGSASL	FPGS	486	Q05932
AASGVVPGSLWPSPE	GADD45GIP1	66	Q8TAE8
WSTGSGPESSQTLPP	COL7A1	631	Q02388
LWAAGTPSPSAPGAR	CDH22	36	Q9UJ99
EGGCLLWSPGPSSSS	DLEC1	1331	Q9Y238
GSPEKGSPSLAWAPS	SCAP	951	Q12770
GSPSLAWAPSAEGSI	SCAP	956	Q12770
TGKWPSLPETPTGLA	PPRC1	776	Q5VV67
LSPGSKPSTWVSCPG	PPP1R15A	211	O75807
GSPLAPSGTSVPFWV	ICAM4	36	Q14773
LNWLPGSPSAEPGKS	MRC1	301	P22897
GASSLWDPASPAPTS	PHF1	11	O43189
SGGSGPGSLWSKPTP	MEX3B	256	Q6ZN04
PAWDDPGSTGSPNLR	HSFX1	46	Q9UBD0
TGSLPPLGSWRSGLS	RUSC2	851	Q8N2Y8
DGTSFLLTAGPSSWP	SOHLH1	301	Q5JUK2
PPSAALLAGALWSPG	PLEKHH3	581	Q7Z736
GGTSVGWDSPPASPL	SNTA1	181	Q13424
DGDASPPSPARWSLG	SLBP	16	Q14493
PLASGTAWLGLPPAS	TMEM132A	756	Q24JP5
WSAEASGKPSPSDPG	MIA3	1716	Q5JRA6
GGDISPVSPSRAWSP	SYNPO	886	Q8N3V7
PPWSPAATSSGNLSS	PTCH2	1181	Q9Y6C5
SPESGPGSWTSPPLL	GDF7	166	Q7Z4P5
FEGTPWSPSLPASSD	SMG7	981	Q92540
QAEDLGSWSPPAGSP	PROSER3	446	Q2NL68
TEWQRSGAPPPSGSA	SRPK1	236	Q96SB4
STSPLDGAPWPGLLL	SSC5D	131	A1L4H1
APAGWGTTPASPTLS	OLFML2B	466	Q68BL8
SLWVPSGEGSAALAP	SOWAHB	566	A6NEL2
PPPGSGDASDWTSSD	FAM110D	201	Q8TAY7
LLGPAPGVSWTAGSP	ALK	101	Q9UM73
SPAWTDSASLGPEPL	CNKSR1	336	Q969H4
SSEEGPSGLPGPWAF	INPP5J	936	Q15735
PTTSSGWEPRLGSPF	TBX10	21	O75333
HWGASPSGAPTLPFA	TLX1NB	46	P0CAT3
GPGLSASEGWAPPHS	ZNF513	501	Q8N8E2
DISLDLPGSSTPFWP	USP22	326	Q9UPT9
LPGSSTPFWPLSPGS	USP22	331	Q9UPT9
PGPGLRSDWHASSPL	TICRR	1441	Q7Z2Z1
TDGWSSINCGTLPPP	RGS12	561	O14924
SLPWDVGSTGTAPPG	SHC2	381	P98077
FPSLSSPSGTAWGPP	PRR19	266	A6NJB7
SPSGTAWGPPTAFDL	PRR19	271	A6NJB7
PKEGLPDTAGSSPWL	SPOCD1	1016	Q6ZMY3
PSGLEQPSPSWSSRA	SCARF2	536	Q96GP6
SQSVPGAWPGASPLS	TNS1	731	Q9HBL0
GAWPGASPLSSQPLS	TNS1	736	Q9HBL0
SEAATLPWGTGPQPS	TMEM79	71	Q9BSE2
GPWSLSPSDSSPSGV	ZFP36	36	P26651
DENWLSPRPASGPSS	NFATC3	251	Q12968
SWQPGTPGTLPASAY	ROBO2	541	Q9HCK4
EFLPTSWSPVGAGPT	RPAP1	596	Q9BWH6
PDQLTSSGAPFWSGP	UBA1	731	P22314
VLGPWFTADSGTPAP	TMEM208	141	Q9BTX3
PGPAAWEGLSGAATP	ZNF446	286	Q9NWS9
APPLDATWPFGASPS	ZNF469	1786	Q96JG9
GSPLEDPSSWPPGSV	ZNF469	2191	Q96JG9
GDPGTASAPPAWLLL	UBAP1L	66	F5GYI3
GQLCSPEPDWLPSSG	UNQ6494/PRO21346	101	Q6UXR6
TEAGPSWGDLPDSPQ	RELT	371	Q969Z4
SPTSASLPWALLGPG	VWA5B2	1101	Q8N398
DSPPWSPALAAEGRG	ZNF41	6	P51814
PGPSNPTSSGDWDSS	TOX2	451	Q96NM4
AGGTAPLPPWKSPSS	ZYX	191	Q15942
SGPPLTTTLPAWCGL	SLC9A7	616	Q96T83
TWLSDPPGAGTYPTL	THAP4	431	Q8WY91
TSLWGPPSSSDPRGI	TNRC6A	1926	Q8NDV7
SPLSLDAGLGQAPWS	TRPM4	546	Q8TD43
AAPAPPRWSSSGSGS	ZDHHC18	41	Q9NUE0
TWVEGASSPRPPSSG	ZNF219	586	Q9P2Y4
WSSIPASPASRPGSF	TRIO	2486	O75962
AGHTFSWGPSLSPTP	ZNF692	116	Q9BU19
WGTPPATGTEASPTA	RNF39	116	Q9H2S5
SAWNSDPVPGSRTPG	USP54	1616	Q70EL1
LTGSPWPGTAAPAAS	TH	41	P07101
GAGTPLPWASSSPTS	FAM53A	231	Q6NSI3
PAEGLDFPSGWGLSP	NACAD	241	O15069
SPSPPTDATGSLGEW	SLC4A1AP	16	Q9BWU0