Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyBiologicalProcessintermediate filament cytoskeleton organization

KRT5 KRT6A EVPL KRT6C PKP2 PLEC

1.84e-05991146GO:0045104
GeneOntologyBiologicalProcessintermediate filament-based process

KRT5 KRT6A EVPL KRT6C PKP2 PLEC

1.95e-051001146GO:0045103
GeneOntologyCellularComponentintermediate filament

KRT5 KRT6A NCKIPSD EVPL KRT6C PKP2 PLEC

2.93e-042271177GO:0005882
GeneOntologyCellularComponentphosphorylase kinase complex

PHKA1 PHKA2

3.07e-0451172GO:0005964
GeneOntologyCellularComponentprotein kinase complex

ERCC2 CEACAM5 INSRR CCNG2 PHKA1 PHKA2

3.93e-041701176GO:1902911
GeneOntologyCellularComponentpolymeric cytoskeletal fiber

CUL3 KNTC1 KRT5 KRT6A NCKIPSD TRIM54 EVPL KRT6C PDE4DIP TRIM55 TRIM63 PKP2 PLEC DNAH11

5.03e-0489911714GO:0099513
HumanPhenoStratum basale cleavage

KRT5 ITGB4 PLEC

1.18e-064353HP:0034193
HumanPhenoSkin fragility with non-scarring blistering

KRT5 ITGB4 PLEC

1.18e-064353HP:0007585
HumanPhenoIntra-epidermal blistering

KRT5 ITGB4 PLEC

5.86e-066353HP:0033802
HumanPhenoAplasia cutis congenita on trunk or limbs

KRT5 ITGB4 PLEC

5.86e-066353HP:0007589
HumanPhenoAcral blistering

KRT5 ITGB4 PLEC

2.43e-059353HP:0031045
HumanPhenoBlistering by anatomical location

KRT5 KRT6A ITGB4 PLEC

2.51e-0526354HP:0033800
HumanPhenoAbnormal dermatological laboratory findings

KRT5 ITGB4 PLEC

3.45e-0510353HP:0003340
HumanPhenoLamina lucida cleavage

KRT5 ITGB4 PLEC

3.45e-0510353HP:0003341
HumanPhenoOnychogryposis

KRT5 KRT6A ITGB4 PLEC

3.93e-0529354HP:0001805
HumanPhenoPalmoplantar blistering

KRT5 KRT6A PLEC

4.72e-0511353HP:0007446
HumanPhenoSubepidermal blistering

KRT5 ITGB4 PLEC

4.72e-0511353HP:0033804
HumanPhenoBlistering by histological location

KRT5 ITGB4 PLEC

8.11e-0513353HP:0033801
HumanPhenoOral mucosal blisters

KRT5 ITGB4 PLEC

1.03e-0414353HP:0200097
HumanPhenoCongenital pyloric atresia

ITGB4 PLEC

1.37e-043352HP:0004399
HumanPhenoMilia

KRT5 ITGB4 PLEC

1.89e-0417353HP:0001056
HumanPhenoPregnancy history

ITGB4 ABCB4 DNAAF3 PLEC NOS3 CCDC40 DNAH11

1.91e-04182357HP:0002686
HumanPhenoPast medical history

ITGB4 ABCB4 DNAAF3 PLEC NOS3 CCDC40 DNAH11

1.97e-04183357HP:0032443
HumanPhenoAbnormal axonemal organization of respiratory motile cilia

CCDC40 DNAH11

2.73e-044352HP:0012258
HumanPhenoProgressive microcephaly

PCLO IQSEC2 SMPD4 CC2D1A VPS53

3.46e-0491355HP:0000253
HumanPhenoAplasia of the bladder

ITGB4 PLEC

4.53e-045352HP:0010477
HumanPhenoElevated maternal circulating alpha-fetoprotein concentration

ITGB4 PLEC

4.53e-045352HP:0011432
DomainDUF3669_Znf

ZNF212 ZNF783 ZNF746 ZNF398 ZNF282

4.23e-1161125IPR022137
DomainDUF3669

ZNF212 ZNF783 ZNF746 ZNF398 ZNF282

4.23e-1161125PF12417
DomainCOS

TRIM54 TRIM67 TRIM55 TRIM63

5.84e-07121124PS51262
DomainCOS_domain

TRIM54 TRIM67 TRIM55 TRIM63

5.84e-07121124IPR017903
DomainAngiomotin

AMOTL1 AMOTL2

1.07e-0431122IPR009114
DomainGlyco_hydro_15/PHK

PHKA1 PHKA2

1.07e-0431122IPR011613
DomainPHK_A/B_su

PHKA1 PHKA2

1.07e-0431122IPR008734
DomainGlyco_hydro_15

PHKA1 PHKA2

1.07e-0431122PF00723
DomainAngiomotin_C

AMOTL1 AMOTL2

1.07e-0431122IPR024646
DomainAngiomotin_C

AMOTL1 AMOTL2

1.07e-0431122PF12240
DomainKeratin_2_head

KRT5 KRT6A KRT6C

3.88e-04241123IPR032444
DomainKeratin_2_head

KRT5 KRT6A KRT6C

3.88e-04241123PF16208
DomainKeratin_II

KRT5 KRT6A KRT6C

4.94e-04261123IPR003054
Domain-

EVPL PLEC

5.26e-04611223.90.1290.10
DomainSpectrin_repeat

EVPL SPTBN5 PLEC

6.85e-04291123IPR002017
DomainPlectin

EVPL PLEC

7.34e-0471122PF00681
DomainPlectin_repeat

EVPL PLEC

7.34e-0471122IPR001101
DomainPLEC

EVPL PLEC

7.34e-0471122SM00250
DomainBBOX

TRIM54 TRIM67 TRIM55 TRIM63

7.85e-04691124SM00336
Domain-

TRIM54 TRIM67 TRIM55 TRIM63

8.74e-047111244.10.45.10
DomainSPEC

EVPL SPTBN5 PLEC

9.17e-04321123SM00150
DomainSpectrin/alpha-actinin

EVPL SPTBN5 PLEC

9.17e-04321123IPR018159
Domainzf-B_box

TRIM54 TRIM67 TRIM55 TRIM63

9.21e-04721124PF00643
Domain6hp_glycosidase

PHKA1 PHKA2

9.75e-0481122IPR012341
DomainChond_GalNAc

CSGALNACT2 B4GALNT3

9.75e-0481122IPR008428
DomainCHGN

CSGALNACT2 B4GALNT3

9.75e-0481122PF05679
Domain-

PHKA1 PHKA2

9.75e-04811221.50.10.10
DomainAB_hydrolase_1

ABHD14A ABHD16B ABHD13

1.00e-03331123IPR000073
Domainzf-RING_UBOX

TRIM54 TRIM55 TRIM63

1.10e-03341123PF13445
DomainZnf-RING_LisH

TRIM54 TRIM55 TRIM63

1.10e-03341123IPR027370
DomainHydrolase_4

ABHD14A ABHD13

1.25e-0391122IPR022742
DomainHydrolase_4

ABHD14A ABHD13

1.25e-0391122PF12146
DomainFN3

VASN INSRR MDGA2 ITGB4 FNDC1 TRIM67

1.27e-031991126PS50853
DomainZF_BBOX

TRIM54 TRIM67 TRIM55 TRIM63

1.37e-03801124PS50119
DomainZnf_B-box

TRIM54 TRIM67 TRIM55 TRIM63

1.43e-03811124IPR000315
DomainFN3_dom

VASN INSRR MDGA2 ITGB4 FNDC1 TRIM67

1.63e-032091126IPR003961
Domaint-SNARE

KRT6A ZNF746 AMOTL2

2.18e-03431123IPR010989
Domain6-hairpin_glycosidase-like

PHKA1 PHKA2

2.66e-03131122IPR008928
Domainfn3

VASN INSRR ITGB4 FNDC1 TRIM67

2.94e-031621125PF00041
DomainPH_dom-like

ARHGAP26 IQSEC2 VPS36 PTPN21 ARHGEF25 SPTBN5 LRBA RASAL1

4.14e-034261128IPR011993
DomainFN3

VASN INSRR ITGB4 FNDC1 TRIM67

5.16e-031851125SM00060
DomainFd_Rdtase_FAD-bd

DUOX1 NOS3

5.70e-03191122IPR017927
DomainFAD_FR

DUOX1 NOS3

5.70e-03191122PS51384
DomainRiboflavin_synthase-like_b-brl

DUOX1 NOS3

5.70e-03191122IPR017938
PathwayREACTOME_TYPE_I_HEMIDESMOSOME_ASSEMBLY

KRT5 ITGB4 PLEC

1.92e-059883MM15117
PathwayREACTOME_TYPE_I_HEMIDESMOSOME_ASSEMBLY

KRT5 ITGB4 PLEC

3.74e-0511883M27372
Pubmed

Cytoplasmic plaque formation in hemidesmosome development is dependent on SoxF transcription factor function.

KRT5 VWF ITGB4 PLEC

9.10e-0813119422962592
Pubmed

Identification of muscle specific ring finger proteins as potential regulators of the titin kinase domain.

TRIM54 TRIM55 TRIM63

1.56e-074119311243782
Pubmed

E3-ligase knock down revealed differential titin degradation by autopagy and the ubiquitin proteasome system.

TRIM54 TRIM55 TRIM63

7.75e-076119334702928
Pubmed

A conserved acetylation switch enables pharmacological control of tubby-like protein stability.

CUL3 RANBP10 RNF25 CHD9 PHKA1 PHKA2 STRN PDE4DIP

1.07e-06223119833187986
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

ABCC3 RANBP10 ERCC2 PIEZO1 ARHGAP26 FRMD8 CC2D1A IRF5 SFI1 ITGB4 ZNF398 PLEC LRBA TTC38 RASAL1 BAHCC1

1.21e-0611051191635748872
Pubmed

Muscle-specific RING finger-1 interacts with titin to regulate sarcomeric M-line and thick filament structure and may have nuclear functions via its interaction with glucocorticoid modulatory element binding protein-1.

TRIM54 TRIM55 TRIM63

1.35e-067119311927605
Pubmed

Developmental regulation of MURF ubiquitin ligases and autophagy proteins nbr1, p62/SQSTM1 and LC3 during cardiac myofibril assembly and turnover.

TRIM54 TRIM55 TRIM63

3.23e-069119321185285
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

VGF CUL3 RANBP10 IQSEC2 JAKMIP3 STRN TRIM67 PDE4DIP ELAVL4 TNKS SSH2 PCDH8 RASAL1 TP53BP1

5.67e-069631191428671696
Pubmed

Amotl1 mediates sequestration of the Hippo effector Yap1 downstream of Fat4 to restrict heart growth.

AMOTL1 PKP2 AMOTL2

6.32e-0611119328239148
Pubmed

Interaction of the bullous pemphigoid antigen 1 (BP230) and desmoplakin with intermediate filaments is mediated by distinct sequences within their COOH terminus.

KRT5 ITGB4 PLEC

6.32e-0611119312802069
Pubmed

Current insights into the formation and breakdown of hemidesmosomes.

KRT5 ITGB4 PLEC

6.32e-0611119316757171
Pubmed

Defining BMP functions in the hair follicle by conditional ablation of BMP receptor IA.

KRT5 KRT6A ITGB4

8.40e-0612119314610062
Pubmed

p63 Transcription Factor Regulates Nuclear Shape and Expression of Nuclear Envelope-Associated Genes in Epidermal Keratinocytes.

SUN1 ITGB4 PLEC

8.40e-0612119328595999
Pubmed

Cell cycle and adhesion defects in mice carrying a targeted deletion of the integrin beta4 cytoplasmic domain.

KRT5 ITGB4 PLEC

1.09e-051311939670011
Pubmed

The multiphosphorylation domain of the phosphorylase kinase alpha M and alpha L subunits is a hotspot of differential mRNA processing and of molecular evolution.

PHKA1 PHKA2

1.16e-05211928226841
Pubmed

Epidermolysis bullosa with congenital pyloric atresia: novel mutations in the beta 4 integrin gene (ITGB4) and genotype/phenotype correlations.

ITGB4 PLEC

1.16e-052119211328943
Pubmed

Placental expression of striatin & endothelial nitric oxide synthase in women with & without pre-eclampsia.

STRN NOS3

1.16e-052119237147942
Pubmed

Modeling and experimental validation of the binary complex of the plectin actin-binding domain and the first pair of fibronectin type III (FNIII) domains of the beta4 integrin.

ITGB4 PLEC

1.16e-052119215817481
Pubmed

Endothelial von Willebrand factor release due to eNOS deficiency predisposes to thrombotic microangiopathy in mouse aging kidney.

VWF NOS3

1.16e-052119220363914
Pubmed

Mammary mechanobiology - investigating roles for mechanically activated ion channels in lactation and involution.

KRT5 PIEZO1

1.16e-052119233262312
Pubmed

X-linked liver glycogenosis type II (XLG II) is caused by mutations in PHKA2, the gene encoding the liver alpha subunit of phosphorylase kinase.

PHKA1 PHKA2

1.16e-05211928733133
Pubmed

Cytokeratin 5/6 expression in pT1 bladder cancer predicts intravesical recurrence in patients treated with bacillus Calmette-Guérin instillation.

KRT5 KRT6A

1.16e-052119235527047
Pubmed

Widespread aplasia cutis congenita in sibs with PLEC1 and ITGB4 variants.

ITGB4 PLEC

1.16e-052119231184804
Pubmed

KIAA1549 promotes the development and chemoresistance of colorectal cancer by upregulating ERCC2.

ERCC2 KIAA1549

1.16e-052119237140813
Pubmed

cDNA cloning of a liver isoform of the phosphorylase kinase alpha subunit and mapping of the gene to Xp22.2-p22.1, the region of human X-linked liver glycogenosis.

PHKA1 PHKA2

1.16e-05211921372435
Pubmed

Expression of MuRF1 or MuRF2 is essential for the induction of skeletal muscle atrophy and dysfunction in a murine pulmonary hypertension model.

TRIM55 TRIM63

1.16e-052119232340625
Pubmed

Collapse of the keratin filament network through the expression of mutant keratin 6c observed in a case of focal plantar keratoderma.

KRT6A KRT6C

1.16e-052119223662636
Pubmed

Muscle ring finger 1 and muscle ring finger 2 are necessary but functionally redundant during developmental cardiac growth and regulate E2F1-mediated gene expression in vivo.

TRIM55 TRIM63

1.16e-052119223512667
Pubmed

New cardiac and skeletal protein aggregate myopathy associated with combined MuRF1 and MuRF3 mutations.

TRIM54 TRIM63

1.16e-052119225801283
Pubmed

Muscle RING-finger 2 and 3 maintain striated-muscle structure and function.

TRIM54 TRIM55

1.16e-052119227493870
Pubmed

Muscle ring finger 1, but not muscle ring finger 2, regulates cardiac hypertrophy in vivo.

TRIM55 TRIM63

1.16e-052119217272810
Pubmed

Comprehensive Gene Expression Analyses of Immunohistochemically Defined Subgroups of Muscle-Invasive Urinary Bladder Urothelial Carcinoma.

KRT5 KRT6A

1.16e-052119233435173
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

CUL3 ZNF212 PIEZO1 ARHGAP26 SUN1 KIAA1549 SMPD4 SFI1 CEMIP2 AMOTL2

1.47e-055291191014621295
Pubmed

Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.

KNTC1 CCP110 NCKIPSD KIAA1549 NEK4 STRN AMOTL1 PKP2 AMOTL2

2.41e-05446119924255178
Pubmed

Genetic variants in pachyonychia congenita-associated keratins increase susceptibility to tooth decay.

KRT6A KRT6C

3.47e-053119229357356
Pubmed

Making a connection: direct binding between keratin intermediate filaments and desmosomal proteins.

KRT5 KRT6A

3.47e-05311927525601
Pubmed

Cytokeratin 5/6 expression in bladder cancer: association with clinicopathologic parameters and prognosis.

KRT5 KRT6A

3.47e-053119229587848
Pubmed

Muscle RING-finger protein-1 (MuRF1) as a connector of muscle energy metabolism and protein synthesis.

TRIM54 TRIM63

3.47e-053119218222470
Pubmed

Transient association of titin and myosin with microtubules in nascent myofibrils directed by the MURF2 RING-finger protein.

TRIM55 TRIM63

3.47e-053119212414993
Pubmed

Differential expression of the motin family in the peri-implantation mouse uterus and their hormonal regulation.

AMOTL1 AMOTL2

3.47e-053119222813598
Pubmed

Comparative study on the histomorphology and molecular biology of radial artery conduits in patients with diabetes mellitus who underwent coronary bypass surgery.

VWF NOS3

3.47e-053119222972845
Pubmed

Plectin isoform-dependent regulation of keratin-integrin alpha6beta4 anchorage via Ca2+/calmodulin.

ITGB4 PLEC

3.47e-053119219419971
Pubmed

Identification and characterization of a novel tight junction-associated family of proteins that interacts with a WW domain of MAGI-1.

AMOTL1 AMOTL2

3.47e-053119216019084
Pubmed

Cytokeratin 5/6, c-Met expressions, and PTEN loss prognostic indicators in triple-negative breast cancer.

KRT5 KRT6A

3.47e-053119224326984
Pubmed

Factor-inhibiting hypoxia-inducible factor (FIH) catalyses the post-translational hydroxylation of histidinyl residues within ankyrin repeat domains.

HIF1AN TNKS

3.47e-053119221251231
Pubmed

Use of immunohistochemical markers can refine prognosis in triple negative breast cancer.

KRT5 KRT6A

3.47e-053119217650314
Pubmed

Structural basis of the interaction between integrin alpha6beta4 and plectin at the hemidesmosomes.

ITGB4 PLEC

3.47e-053119219242489
Pubmed

Cloning and characterization of multiple human genes and cDNAs encoding highly related type II keratin 6 isoforms.

KRT6A KRT6C

3.47e-05311927543104
Pubmed

Angiomotin belongs to a novel protein family with conserved coiled-coil and PDZ binding domains.

AMOTL1 AMOTL2

3.47e-053119212406577
Pubmed

Epidermolysis Bullosa with Pyloric Atresia

ITGB4 PLEC

3.47e-053119220301336
Pubmed

Glucoamylase-like domains in the alpha- and beta-subunits of phosphorylase kinase.

PHKA1 PHKA2

3.47e-053119212876330
Pubmed

Non-Muscle-Invasive Bladder Carcinoma with Respect to Basal Versus Luminal Keratin Expression.

KRT5 KRT6A

3.47e-053119233086575
Pubmed

Plakophilin 2 affects cell migration by modulating focal adhesion dynamics and integrin protein expression.

ITGB4 PKP2

3.47e-053119223884246
Pubmed

GRAF1 integrates PINK1-Parkin signaling and actin dynamics to mediate cardiac mitochondrial homeostasis.

ARHGAP26 PINK1

3.47e-053119238081847
Pubmed

MuRF1 is a muscle fiber-type II associated factor and together with MuRF2 regulates type-II fiber trophicity and maintenance.

TRIM55 TRIM63

3.47e-053119220149877
Pubmed

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.

CUL3 CCP110 RANBP10 ARHGAP26 IQSEC2 HIF1AN NEK4 STRN AMOTL1 DCAF11 PLEC SNRPD3 VPS53 TP53BP1 CCDC40

4.67e-0513211191527173435
Pubmed

AP-2 factors act in concert with Notch to orchestrate terminal differentiation in skin epidermis.

KRT5 KRT6A ITGB4

4.97e-0521119318824566
Pubmed

The RNF146 and tankyrase pathway maintains the junctional Crumbs complex through regulation of angiomotin.

AMOTL1 TNKS AMOTL2

5.74e-0522119327521426
Pubmed

Cytokinesis involves a nontranscriptional function of the Hippo pathway effector YAP.

AMOTL1 PLEC AMOTL2

6.58e-0523119326933062
Pubmed

Angiomotin-like proteins associate with and negatively regulate YAP1.

AMOTL1 AMOTL2

6.93e-054119221187284
Pubmed

Isolation of cDNA clones for the catalytic gamma subunit of mouse muscle phosphorylase kinase: expression of mRNA in normal and mutant Phk mice.

PHKA1 PHKA2

6.93e-05411923472241
Pubmed

Phosphorylation of human keratin 8 in vivo at conserved head domain serine 23 and at epidermal growth factor-stimulated tail domain serine 431.

KRT6A KRT6C

6.93e-05411929054461
Pubmed

Role of binding of plectin to the integrin beta4 subunit in the assembly of hemidesmosomes.

ITGB4 PLEC

6.93e-054119214668477
Pubmed

Angiomotin'g YAP into the nucleus for cell proliferation and cancer development.

AMOTL1 AMOTL2

6.93e-054119224003252
Pubmed

Cytokeratin 5/6 and cytokeratin 8/18 expression in triple negative breast cancers: clinicopathologic significance in South-Asian population.

KRT5 KRT6A

6.93e-054119229884220
Pubmed

Phosphorylase Kinase Deficiency

PHKA1 PHKA2

6.93e-054119221634085
Pubmed

Myosin accumulation and striated muscle myopathy result from the loss of muscle RING finger 1 and 3.

TRIM54 TRIM63

6.93e-054119217786241
Pubmed

The endothelial E3 ligase HECW2 promotes endothelial cell junctions by increasing AMOTL1 protein stability via K63-linked ubiquitination.

AMOTL1 AMOTL2

6.93e-054119227498087
Pubmed

Angiomotin regulates endothelial cell migration during embryonic angiogenesis.

AMOTL1 AMOTL2

6.93e-054119217699752
Pubmed

Perturbation of the titin/MURF1 signaling complex is associated with hypertrophic cardiomyopathy in a fish model and in human patients.

TRIM55 TRIM63

6.93e-054119231628103
Pubmed

Rapid and widespread suppression of self-renewal by microRNA-203 during epidermal differentiation.

KRT5 ITGB4

6.93e-054119223571213
Pubmed

Striatin assembles a membrane signaling complex necessary for rapid, nongenomic activation of endothelial NO synthase by estrogen receptor alpha.

STRN NOS3

6.93e-054119215569929
Pubmed

Cleavage of phosphorylase kinase and calcium-free calmodulin by HIV-1 protease.

PHKA1 PHKA2

6.93e-05411921872871
Pubmed

A novel function of the proneural factor Ascl1 in progenitor proliferation identified by genome-wide characterization of its targets.

CEMIP2 CCNG2 TP53BP1

8.50e-0525119321536733
Pubmed

Human chromosome 7: DNA sequence and biology.

ZNF212 PCLO IRF5 ATP6V1F ABCB4 TMUB1 FASTK ZNF398 ZNF282

9.90e-05536119912690205
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

CUL3 KRT5 KRT6A VWF ARHGAP26 PCLO IQSEC2 NCKIPSD KIAA1549 STRN PDE4DIP SSH2 PLEC RASAL1 DNAH11

1.14e-0414311191537142655
Pubmed

High prevalence of respiratory ciliary dysfunction in congenital heart disease patients with heterotaxy.

CCDC40 DNAH11

1.15e-045119222499950
Pubmed

Role for keratins 6 and 17 during wound closure in embryonic mouse skin.

KRT5 KRT6A

1.15e-045119212557214
Pubmed

Unaltered striatal dopamine release levels in young Parkin knockout, Pink1 knockout, DJ-1 knockout and LRRK2 R1441G transgenic mice.

KHDRBS2 PINK1

1.15e-045119224733019
Pubmed

The diagnostic utility of D2-40, calretinin, CK5/6, desmin and MOC-31 in the differentiation of mesothelioma from adenocarcinoma in pleural effusion cytology.

KRT5 KRT6A

1.15e-045119223075894
Pubmed

Angiomotin is a novel Hippo pathway component that inhibits YAP oncoprotein.

AMOTL1 AMOTL2

1.15e-045119221205866
Pubmed

Location of phosphorylase kinase (Phk) in the mouse X chromosome.

PHKA1 PHKA2

1.15e-04511924726088
Pubmed

Airway hillocks are injury-resistant reservoirs of unique plastic stem cells.

KRT5 KRT6A

1.15e-045119238693267
Pubmed

Structural insights into Ca2+-calmodulin regulation of Plectin 1a-integrin β4 interaction in hemidesmosomes.

ITGB4 PLEC

1.15e-045119225703379
Pubmed

Pachyonychia Congenita

KRT6A KRT6C

1.15e-045119220301457
Pubmed

Three epidermal and one simple epithelial type II keratin genes map to human chromosome 12.

KRT5 KRT6A

1.15e-04511921713141
Pubmed

Homologous pairing preceding SPO11-mediated double-strand breaks in mice.

SUN1 PSMC3IP

1.15e-045119223318132
Pubmed

Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.

CACNA1B NAA15 PCLO IQSEC2 SUN1 STRN ELFN1 PDE4DIP ELAVL4 PLEC PCDH8 RASAL1 TP53BP1

1.47e-0411391191336417873
Pubmed

Ets1 blocks terminal differentiation of keratinocytes and induces expression of matrix metalloproteases and innate immune mediators.

KRT5 KRT6A ITGB4

1.64e-0431119320930145
Pubmed

ΔNp63 knockout mice reveal its indispensable role as a master regulator of epithelial development and differentiation.

KRT5 ITGB4 PKP2

1.64e-0431119322274697
Pubmed

An intrinsic gut leptin-melanocortin pathway modulates intestinal microsomal triglyceride transfer protein and lipid absorption.

VWF MTTP

1.73e-046119220164094
Pubmed

Identification of 14-3-3sigma mutation causing cutaneous abnormality in repeated-epilation mutant mouse.

KRT5 KRT6A

1.73e-046119216239341
Pubmed

Keratin 6 is not essential for mammary gland development.

KRT5 KRT6A

1.73e-046119216790075
Pubmed

Stem Cell Lineage Infidelity Drives Wound Repair and Cancer.

KRT5 ITGB4

1.73e-046119228434617
Pubmed

Angiomotin functions in HIV-1 assembly and budding.

AMOTL1 AMOTL2

1.73e-046119225633977
Pubmed

Molecular characterization of angiomotin/JEAP family proteins: interaction with MUPP1/Patj and their endogenous properties.

AMOTL1 AMOTL2

1.73e-046119217397395
Pubmed

Junctional Epidermolysis Bullosa

ITGB4 PLEC

1.73e-046119220301304
Pubmed

p63(+)Krt5(+) distal airway stem cells are essential for lung regeneration.

KRT5 KRT6A

1.73e-046119225383540
Pubmed

Characterization of the human COP9 signalosome complex using affinity purification and mass spectrometry.

CUL3 NCKIPSD AMOTL1

1.80e-0432119318850735
Pubmed

Primary Ciliary Dyskinesia

DNAAF3 CCDC40 DNAH11

1.80e-0432119320301301
InteractionZNF767P interactions

ZNF212 ZNF767P ZNF783 ZNF746 TRIM55 TRIM63 ZNF398 ZNF282

1.17e-14161168int:ZNF767P
InteractionZNF783 interactions

ZNF212 ZNF767P ZNF783 ZNF746 ZNF398

2.60e-09111165int:ZNF783
InteractionZNF282 interactions

CUL3 ZNF212 ZNF767P ZNF746 ZNF398 ZNF282

2.97e-09231166int:ZNF282
InteractionZNF398 interactions

CUL3 ZNF212 ZNF767P ZNF783 ZNF746 ZNF398 ZNF282

4.73e-09431167int:ZNF398
InteractionZNF212 interactions

ZNF212 ZNF767P ZNF783 ZNF746 ZNF398 ZNF282

3.65e-07491166int:ZNF212
InteractionZNF667-AS1 interactions

TRIM54 TRIM55 TRIM63

1.84e-0651163int:ZNF667-AS1
InteractionKRT6C interactions

KRT5 KRT6A TRIM54 TRIM67 KRT6C PLEC

5.03e-06761166int:KRT6C
InteractionC1orf35 interactions

CUL3 ARHGAP26 TRIM54 CHD9 EVPL ARL4D TRIM67 TRIM55 TRIM63 PINK1

1.05e-0530411610int:C1orf35
InteractionKRT31 interactions

CUL3 KRT5 KRT6A VASN INPP5K CCDC187 ITGB4 PRR35 KRT6C PDE4DIP PKP2 AMOTL2

1.20e-0545311612int:KRT31
InteractionKRT14 interactions

CUL3 KRT5 KRT6A EVPL ARL4D TRIM67 KRT6C PLEC

1.55e-051921168int:KRT14
InteractionKRT5 interactions

CUL3 KRT5 KRT6A EVPL HIF1AN TRIM67 KRT6C PKP2

1.61e-051931168int:KRT5
InteractionGMDS interactions

CUL3 HIF1AN TRIM67 TNKS TTC38

2.67e-05611165int:GMDS
InteractionATXN3L interactions

TRIM54 TRIM55 TRIM63

2.96e-05111163int:ATXN3L
InteractionZNF649 interactions

CUL3 TRIM55 TRIM63

2.96e-05111163int:ZNF649
InteractionEVPL interactions

CUL3 KRT5 EVPL FNDC1 PDE4DIP PINK1

3.41e-051061166int:EVPL
InteractionUBASH3B interactions

CUL3 KRT5 KRT6A PTPN21 PRR35 TRIM67 TNKS

3.49e-051571167int:UBASH3B
InteractionKRT19 interactions

CUL3 KRT5 KRT6A SFI1 TRIM67 KRT6C AMOTL1 PLEC AMOTL2

3.74e-052821169int:KRT19
InteractionC8orf74 interactions

TRIM54 TRIM55 TRIM63

5.10e-05131163int:C8orf74
InteractionKRT38 interactions

CCP110 KRT5 KRT6A KRT6C AMOTL2 VPS53 CCDC40

6.23e-051721167int:KRT38
InteractionMTR interactions

CUL3 ARL4D NEK4 TRIM67 DCAF11 PLEC

6.53e-051191166int:MTR
InteractionZNF566 interactions

CUL3 TRIM55 TRIM63

8.04e-05151163int:ZNF566
InteractionCLEC12B interactions

PIEZO1 TUSC3 SUN1 GLB1L2 CEMIP2 CSGALNACT2 B4GALNT3

9.52e-051841167int:CLEC12B
InteractionCOPS8 interactions

CUL3 NCKIPSD IRF5 TRIM67 DCAF11 PINK1

9.79e-051281166int:COPS8
InteractionLINC00905 interactions

TRIM55 TRIM63

9.82e-0531162int:LINC00905
InteractionUBE2E3 interactions

CUL3 RNF25 TRIM54 ZNF746 TRIM55 TRIM63

1.16e-041321166int:UBE2E3
InteractionZNF57 interactions

CUL3 TRIM55 TRIM63

1.19e-04171163int:ZNF57
InteractionDCAF11 interactions

CUL3 TRIM67 TRIM55 TRIM63 DCAF11 LRBA

1.37e-041361166int:DCAF11
InteractionKRT16 interactions

CUL3 KRT5 KRT6A TRIM67 KRT6C AMOTL1 PLEC

1.46e-041971167int:KRT16
InteractionKRT18 interactions

CUL3 KNTC1 CCP110 KRT5 KRT6A TRIM67 KRT6C PDE4DIP PKP2 PLEC

1.56e-0441911610int:KRT18
InteractionVAC14 interactions

CUL3 PHKA1 TRIM67 PDE4DIP TRIM55 TRIM63 TP53BP1

1.65e-042011167int:VAC14
InteractionKRT84 interactions

CUL3 KRT5 KRT6A KRT6C

1.81e-04491164int:KRT84
InteractionACTG2 interactions

NEK4 TRIM67 PLEC PINK1

1.81e-04491164int:ACTG2
InteractionLINC00518 interactions

TRIM55 TRIM63

1.96e-0441162int:LINC00518
InteractionLYNX1 interactions

TRIM55 TRIM63

1.96e-0441162int:LYNX1
InteractionAPOBEC4 interactions

TRIM55 TRIM63

1.96e-0441162int:APOBEC4
InteractionGOLGA2P5 interactions

TRIM55 TRIM63

1.96e-0441162int:GOLGA2P5
InteractionKYAT1 interactions

TRIM67 TRIM55 TRIM63

1.97e-04201163int:KYAT1
InteractionPHTF1 interactions

KRT5 KRT6A KRT6C

1.97e-04201163int:PHTF1
InteractionIRF3 interactions

IRF5 TRIM67 TRIM55 TRIM63 VPS53 PINK1

2.25e-041491166int:IRF3
CytobandEnsembl 112 genes in cytogenetic band chr7q36

ZNF212 ZNF767P ZNF783 TMUB1 FASTK ZNF746 ZNF398 ZNF282 NOS3

3.99e-101591199chr7q36
Cytoband7q36.1

ZNF212 ZNF767P ZNF783 TMUB1 ZNF746 ZNF398 ZNF282

1.02e-097411977q36.1
Cytoband17q25

CEP295NL EVPL ITGB4

1.45e-0439119317q25
CytobandEnsembl 112 genes in cytogenetic band chr17q25

CEP295NL EVPL ITGB4 NOTUM CCDC40 BAHCC1

1.57e-043071196chr17q25
Cytoband12q13.13

KRT5 KRT6A KRT6C

7.21e-0467119312q13.13
GeneFamilyAbhydrolase domain containing

ABHD14A ABHD16B ABHD13

1.08e-04227734
GeneFamilyKeratins, type II

KRT5 KRT6A KRT6C

2.02e-0427773609
GeneFamilyEF-hand domain containing|Plakins

EVPL PLEC

4.93e-048772939
GeneFamilyFibronectin type III domain containing

INSRR ITGB4 FNDC1 TRIM67 ELFN1

6.03e-04160775555
GeneFamilyRing finger proteins|Tripartite motif containing|ARF GTPase family

TRIM54 TRIM67 TRIM55 TRIM63

7.22e-049577459
GeneFamilyBeta 4-glycosyltransferases

CSGALNACT2 B4GALNT3

2.34e-0317772425
ToppCellIPF-Epithelial-Basal|Epithelial / Disease state, Lineage and Cell class

ABCC3 KRT5 KRT6A KHDRBS2 ITGB4 ARL4D AMOTL1

7.61e-0719011874f15842b424eefadbfe451875e517cf70e29607f
ToppCelldroplet-Lung-1m-Endothelial-venous_endothelial|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

VWF ITGB4 CEMIP2 ARL4D AMOTL1 AMOTL2 NOS3

8.17e-0719211871990dc8a81594018a5bf596be99d0b5f0af0f58f
ToppCelldroplet-Lung-1m-Endothelial-venous_endothelial-vein_endothelial_cell-vein_endothelial_cell|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

VWF ITGB4 CEMIP2 ARL4D AMOTL1 AMOTL2 NOS3

8.17e-071921187845cc9c18b4436b07dd3ce7980052683937546d2
ToppCelldroplet-Lung-1m-Endothelial-venous_endothelial-vein_endothelial_cell|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

VWF ITGB4 CEMIP2 ARL4D AMOTL1 AMOTL2 NOS3

8.17e-071921187c72a082c93a8825adbfef37f889ba3a7052f201b
ToppCellcontrol|World / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

KRT5 PCLO TUSC3 SUN1 EVPL ITGB4 DUOX1

1.07e-06200118797f36d2c197e03d93a1fc59949d77ae90f6e6a9a
ToppCellNS-control|NS / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

KRT5 PCLO TUSC3 SUN1 EVPL ITGB4 DUOX1

1.07e-062001187ecbe89ff95d046155b984c8c150e0b9e7278f839
ToppCelldroplet-Marrow-BM-1m-Myeloid-basophil|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KRT6A IQSEC2 IRF5 PHKA2 BAHCC1 DNAH11

5.78e-0616811862e88d9cb7c80a4656fab290db8b45a5a0599d769
ToppCellTCGA-Liver-Primary_Tumor-Hepatocellular_Carcinoma-Hepatocellular_Carcinoma-8|TCGA-Liver / Sample_Type by Project: Shred V9

GPLD1 RANBP10 VWF ABCB4 ELFN1 PINK1

6.40e-061711186c4a919fe3d56ae6df2fcab6686abacc10befc053
ToppCellfacs-Heart-LV-3m-Endothelial-endothelial_cell_of_endocardium|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWF ITGB4 CEMIP2 PKP2 AMOTL2 NOS3

6.61e-061721186f2c17c49b375b28ad47dc6cabda62f1c238023dd
ToppCellfacs-Heart-LV-3m-Endothelial-endocardial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWF ITGB4 CEMIP2 PKP2 AMOTL2 NOS3

6.61e-0617211866ab4f01098dddb789df298ddf97b3c384405ee6c
ToppCellE18.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_mature|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

VWF IP6K3 MDGA2 ITGB4 CEMIP2 NOS3

7.30e-0617511862e54961846c65b185d9bd6e305dd81205579d890
ToppCellE18.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

VWF IP6K3 MDGA2 ITGB4 CEMIP2 NOS3

7.30e-061751186efa6a05f7417d46141b6e635f258c126b7a03aa1
ToppCellCaecum-Dendritic_cell-cDC1|Dendritic_cell / Region, Cell class and subclass

CC2D1A SFI1 CCNG2 DCAF11 VPS53 SNX22

7.54e-06176118607cde50e1c18fcc2c5028efe1a087db4ef4d4783
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_ZNF322P1|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

VGF CCNG2 FNDC1 ELFN1 PKP2 PCDH8

8.05e-0617811862a36475c260088f69f3b8c282d910e5eaa5c5c2d
ToppCelldroplet-Lung-LUNG-30m-Endothelial-Artery_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWF EVPL MDGA2 ITGB4 CEMIP2 NOS3

8.31e-061791186a09647750eba9d93c5efc1db3b555fefb5eec7b5
ToppCell3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CCP110 GLB1L2 SLC44A4 DNAAF3 CCDC40 DNAH11

8.58e-06180118692fb01b91261b3103454924cde56add337b41844
ToppCellAT1-AT2_cells-Donor_05|World / lung cells shred on cell class, cell subclass, sample id

CEACAM5 KHDRBS2 EVPL PTPN21 AMOTL2 SNX22

8.85e-061811186ca23ce4f2c7b684d8ddd0e8619b3b696023d75e3
ToppCellAT1-AT2_cells-Donor_02|World / lung cells shred on cell class, cell subclass, sample id

PCLO KHDRBS2 PTPN21 FNDC1 AMOTL2 SNX22

9.42e-0618311866821dca076318115d360ff426eb1218cfe104063
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_ZNF322P1|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

VGF CCNG2 FNDC1 ELFN1 PKP2 PCDH8

1.00e-0518511860b5a0df58ae2ad8261f40f152775747af4f3937a
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

VGF CCNG2 ELFN1 PKP2 ARHGAP28 PCDH8

1.10e-0518811866ee3f8f94ea7bdf652c9575fc65bff08070093a4
ToppCellfacs-Brain_Non-Myeloid-Striatum-3m-Macroglial-oligodendrocyte_precursor_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPLD1 KIAA1549 ABCB4 ELFN1 ELAVL4 SNX22

1.10e-0518811867471c194276161422326647f09022e94f3d1640c
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-3m-Macroglial-oligodendrocyte_precursor_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KHDRBS2 KIAA1549 TRIM67 ELFN1 ELAVL4 SNX22

1.10e-051881186a244fcd092d5bd544e503366b1439b0fbc1ee00e
ToppCellfacs-Brain_Non-Myeloid-Striatum-3m-Macroglial-Oligodendrocyte_progenitor_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPLD1 KIAA1549 ABCB4 ELFN1 ELAVL4 SNX22

1.10e-051881186053c251d3ddbeb866f34565aefca4535517b4387
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-3m-Macroglial-Oligodendrocyte_progenitor_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KHDRBS2 KIAA1549 TRIM67 ELFN1 ELAVL4 SNX22

1.10e-051881186c8530c9ff98666c64a94683261af4288cb790a7e
ToppCellfacs-Brain_Non-Myeloid-Cortex-3m-Macroglial-oligodendrocyte_precursor_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KHDRBS2 KIAA1549 ABCB4 TRIM67 ELFN1 SNX22

1.17e-0519011869b825b2586c7b173ff27fcf2abc5860faf50984a
ToppCellfacs-Brain_Non-Myeloid-Cortex-3m-Macroglial-Oligodendrocyte_progenitor_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KHDRBS2 KIAA1549 ABCB4 TRIM67 ELFN1 SNX22

1.17e-051901186d146af1926474328a7c822bc140c4dda66e1bbfb
ToppCelldroplet-Lung-nan-21m-Endothelial-Vein_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWF ITGB4 CEMIP2 ARL4D AMOTL2 NOS3

1.20e-05191118692b2faa72c184b6ae49530fd3b50848510904997
ToppCellCD8+_Memory_T_cell-CV-7|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster

KNTC1 MMS22L SUN1 SFI1 CEMIP2 LRBA

1.20e-0519111869454f642c3621370fa23640b631301346b300950
ToppCelldroplet-Lung-LUNG-1m-Endothelial-Vein_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWF ITGB4 CEMIP2 ARL4D AMOTL1 NOS3

1.20e-0519111869fc674a58f20b47255e4457d5195c8cff17b0414
ToppCelldroplet-Lung-LUNG-1m-Endothelial-vein_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWF ITGB4 CEMIP2 ARL4D AMOTL1 NOS3

1.20e-051911186c379a499dabf3c9ed80f47adbb2d949821c5b053
ToppCelldroplet-Lung-nan-21m-Endothelial-vein_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWF ITGB4 CEMIP2 ARL4D AMOTL2 NOS3

1.20e-051911186d0bbbf42d00165a53253c833adef65da6ec36bba
ToppCellsaliva-Severe-critical_progression_d12-22_no-steroids-Epithelial-Epithelial,_Airway-secretory_cell-Epi-Secretory|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

KRT5 PTPN21 SLC44A4 PHKA1 B4GALNT3 AMOTL2

1.24e-0519211868899d81306770adda893b5e146df1253971754c5
ToppCellsaliva-Severe-critical_progression_d12-22_no-steroids-Epithelial-Epithelial,_Airway-secretory_cell|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

KRT5 PTPN21 SLC44A4 PHKA1 B4GALNT3 AMOTL2

1.24e-0519211865fda9a465c9f77c7fa1a3ea07a2b0374bbc23b2a
ToppCelldroplet-Lung-21m-Endothelial-venous_endothelial|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

VWF ITGB4 CEMIP2 ARL4D AMOTL2 NOS3

1.31e-051941186db7b0c77ad88f7b74d85679f1fb8ee7140ac3f62
ToppCelldroplet-Lung-21m-Endothelial-venous_endothelial-vein_endothelial_cell|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

VWF ITGB4 CEMIP2 ARL4D AMOTL2 NOS3

1.31e-05194118617d530982789acc5e6889b215f3d433d138a41c4
ToppCelldroplet-Lung-21m-Endothelial-venous_endothelial-vein_endothelial_cell-vein_endothelial_cell|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

VWF ITGB4 CEMIP2 ARL4D AMOTL2 NOS3

1.31e-0519411865992b9409d5855eff2afc3acd201ccd25420d2e0
ToppCelldroplet-Lung-18m-Endothelial-venous_endothelial-vein_endothelial_cell-vein_endothelial_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

VWF ITGB4 CEMIP2 ARL4D AMOTL1 NOS3

1.35e-0519511860c15be3e7c238e329505dcbbe197a977d1019d45
ToppCelldroplet-Lung-18m-Endothelial-venous_endothelial|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

VWF ITGB4 CEMIP2 ARL4D AMOTL1 NOS3

1.35e-05195118645ac0fdbeb0982d798c613a6d15715d725608aa9
ToppCelldroplet-Lung-18m-Endothelial-venous_endothelial-vein_endothelial_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

VWF ITGB4 CEMIP2 ARL4D AMOTL1 NOS3

1.35e-0519511865b1f04a745467876b09113ee17ababd3fcf9fb01
ToppCellNS-control-d_0-4-Epithelial-Squamous|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

KRT6A CEACAM5 VWF VASN CCNG2 RASAL1

1.43e-051971186ab965a0ba87efd3329d24a1ec123985f46fc17c0
ToppCellcontrol-Epithelial-Squamous|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

KRT6A CEACAM5 VWF VASN CCNG2 RASAL1

1.47e-0519811866ba669ac1ed275ae309054941b1457e315766faa
ToppCell5'-Adult-Distal_Rectal|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ABCC3 CEACAM5 VASN SLC44A4 PKP2 B4GALNT3

1.47e-051981186db26c20321f9ab102d6484f22ddb2bde684067b1
ToppCellTracheal-NucSeq-Epithelial-Epi_airway_basal-Basal|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ABCC3 KRT5 KRT6A KHDRBS2 ITGB4 DUOX1

1.52e-05199118694a7867e800df352731796de8c24cba133c29622
ToppCell(02)_MMP9/10+-(1)_GFP|(02)_MMP9/10+ / shred by cell type by condition

KRT5 KRT6A PIEZO1 ITGB4 CEMIP2 PLEC

1.52e-051991186448ba982be804007f991d469eca9d885b21ae499
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-4M-Neuronal|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.

CACNA1B PCLO ARL4D PDE4DIP ELAVL4 PCDH8

1.52e-05199118677b4aa00f14b86ef5db0490be98787e063979541
ToppCellTracheal|World / Cell types per location group and 10X technology with lineage, and cell group designations

KRT5 KRT6A ITPRID1 ITGB4 PKP2 RASAL1

1.56e-052001186682960e28542a3d6c119047cd0131941932cfdea
ToppCellControl_saline-Endothelial-Endothelial-Vein|Control_saline / Treatment groups by lineage, cell group, cell type

VWF ITGB4 ARL4D ELFN1 PLEC NOS3

1.56e-052001186e5f876910bc8cb390d9b46a48d9b6d4d57235551
ToppCellNeuronal-Inhibitory-iA-iA_3(VIP)|Neuronal / cells hierarchy compared to all cells using T-Statistic

VGF CCNG2 ELFN1 PKP2 ARHGAP28 PCDH8

1.56e-05200118675649534a98bc738fca62d071de0978dc61eb24f
ToppCellThalamus-Endothelial-ENDOTHELIAL_STALK-Flt1_2|Thalamus / BrainAtlas - Mouse McCarroll V32

KRT5 VWF IP6K3 PIEZO1 NOS3

2.80e-05133118529b0c2c682c6b97823e7d8d8ba1f5114044b30ba
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Chodl|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

CCDC187 ITGB4 FNDC1 ARHGAP28 CCDC40

3.23e-0513711855cb84392e4483f50e09fb7395e2ec98f3eb6ecf3
ToppCellAT1-AT2_cells-Donor_04|World / lung cells shred on cell class, cell subclass, sample id

CEACAM5 KHDRBS2 PTPN21 AMOTL2 SNX22

3.58e-05140118545d52a086ced8d58e01ac51ac4a90338e8649b16
ToppCellCOVID-19-Heart-CM_5_(RYR2-)|COVID-19 / Disease (COVID-19 only), tissue and cell type

IP6K3 TRIM54 PHKA1 ASB8 TRIM63

4.10e-051441185f92e03dd784e31a9e5dbd4f4c3a6517ea19210cf
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Lmo1_Myl1|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

IP6K3 GLB1L2 ABCB4 ELFN1 PCDH8

4.24e-051451185590ba937c741ae67460f303eca88b1cd3ac87f64
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Lmo1_Fam159b|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

KRT5 GLB1L2 ELFN1 PKP2 PCDH8

4.82e-05149118598ae408d2d0347865875ff8bbd89d359decea526
ToppCell367C-Myeloid-Macrophage-FABP4+_Macrophage_2|367C / Donor, Lineage, Cell class and subclass (all cells)

ABCC3 SNX24 IRF5 NCF2 PKP2

6.00e-0515611851a0e081284a99c1b345990775015b8a2fa469496
ToppCell10x5'-Lung-Lymphocytic_T_CD4-T_CD4/CD8|Lung / Manually curated celltypes from each tissue

PCLO CCDC187 ARHGEF25 LRBA DNAH11

6.00e-05156118510d191e29b16cae8238e8df6c0ff38882253f34e
ToppCellfacs-Marrow-Granulocytes-3m-Lymphocytic|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KRT5 KRT6A KHDRBS2 GLB1L2 ARL4D

6.76e-0516011858590281165eab6514a9f6a022b900d4c222c1044
ToppCelldroplet-Liver-HEPATOCYTES-1m-Epithelial-Hepatocyte_(Pericentral)|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPLD1 ARL4D ABCB4 NOTUM MTTP

6.76e-051601185c42bcc6c7d113f0db43febb088b75ca4ac7cb7a3
ToppCellfacs-Lung-Endomucin-24m-Epithelial-Alveolar_Epithelial_Type_2|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABHD14A KRT5 NCKIPSD PTPN21 SNX22

7.17e-051621185497ae9f86a5e7946d0fde932b35719a382a6b691
ToppCellfacs-Lung-Endomucin-24m-Epithelial-type_II_pneumocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABHD14A KRT5 NCKIPSD PTPN21 SNX22

7.17e-0516211857b2949eba2b4aea239d96ed82aafab13b07624eb
ToppCell356C-Myeloid-Macrophage-FABP4+_Macrophage_4|356C / Donor, Lineage, Cell class and subclass (all cells)

GPLD1 ABCC3 SNX24 CCNG2 MTTP

7.17e-0516211857d43d59531cbefe3ac94953b7faf7156b2a31441
ToppCelldroplet-Lung-nan-18m-Myeloid-intermediate_monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARHGAP26 IRF5 NCF2 CSGALNACT2 SSH2

7.82e-051651185e32697321cef424c2ad4e11ee9da3e510d5ce505
ToppCelldroplet-Lung-nan-18m-Myeloid-Intermediate_Monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARHGAP26 IRF5 NCF2 CSGALNACT2 SSH2

7.82e-0516511850fbdd043e11aa8dbff4cd3a4da1b2feb49878a09
ToppCellfacs-Aorta-Heart-3m-Endothelial-endocardial_endothelial_cells|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWF IP6K3 SNX24 CEMIP2 NOS3

8.28e-051671185a4a795751644b22af616335379e64ae95175180c
ToppCellPND07-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_prolif|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

VWF EVPL CEMIP2 PLEC NOS3

8.51e-05168118532e4d82efaccf336d347e4063253c3635a3ec672
ToppCellfacs-Lung-Endomucin-24m-Endothelial-Vein_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWF ITGB4 CEMIP2 ARL4D NOS3

8.75e-0516911858dba7546adc6b1345933eec81fc77fc9611fae60
ToppCellfacs-Lung-Endomucin-24m-Endothelial-vein_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWF ITGB4 CEMIP2 ARL4D NOS3

8.75e-051691185d2862a7ddee6d7a65d84ef9d0800ba6f4690973f
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1-2_VIP_RPL41P3|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PARD3B ABCB4 FNDC1 ELFN1 ARHGAP28

9.00e-05170118531e3f57673c99f4d8ef30faa9c40e5f7f5bf6460
ToppCellfacs-Marrow-T-cells-3m-Hematologic-MPP_Fraction_B_+_C|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KNTC1 TRIM54 EVPL CCDC40 BAHCC1

9.00e-051701185d70aaa0f4e5034bb9f61b832b5f9123870936d3c
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Ptprt_Pkp2|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

IP6K3 ELFN1 AMOTL1 PKP2 PCDH8

9.00e-05170118514aa86a4f526ed6986afcb28c49225522055550c
ToppCellPND07-Epithelial-Epithelial_Airway-Basal-Basal-Basal_mature|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

KRT5 KRT6A EVPL ITGB4 DUOX1

9.77e-0517311851b2508cc890430bd4b2cf232c633928edb86c57e
ToppCelldroplet-Lung-LUNG-1m-Myeloid-Ccr7+_Dendritic|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IP6K3 PTPN21 DNAAF3 PDE4DIP BAHCC1

1.00e-0417411857be0c6248e77f2d0260b852b01e17892f7828f1b
ToppCellPCW_10-12-Epithelial-Epithelial_ciliated|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

CCDC187 GLB1L2 SLC44A4 DNAAF3 CFAP99

1.00e-041741185b8d1c556290d188f56aeefc17f03119686945fe7
ToppCellCV-Healthy-4|Healthy / Virus stimulation, Condition and Cluster

INSRR NCKIPSD CCNG2 AMOTL1 ZNF282

1.00e-04174118526544cc5f51cb4dc1251e62d9f80b6c956194d38
ToppCellPCW_10-12-Epithelial-Epithelial_ciliated-epi_ciliated_(14)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

CCDC187 GLB1L2 SLC44A4 DNAAF3 CFAP99

1.00e-04174118500cf27bc23af1472a507be31fba6245a8fdd901b
ToppCelldroplet-Lung-1m-Hematologic-myeloid-myeloid_dendritic_cell-Ccr7+_dendritic|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PTPN21 DNAAF3 PDE4DIP ARHGAP28 BAHCC1

1.03e-0417511851b910c08d2bfbcc77431ee66103e63a11a9d39fe
ToppCell3'-Parenchyma_lung-Epithelial-Epithelial_transtional-epithelial_cell_of_lung-Transitional_Club-AT2-Transitional_Club-AT2_L.0.4.1.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CC2D1A MDGA2 PHKA1 DUOX1 BAHCC1

1.03e-041751185dbd9dac129fb6ae5f55e7b96d04b37585458dc4a
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_ZNF322P1|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

VGF CCNG2 FNDC1 PKP2 PCDH8

1.03e-0417511859d09636a103daa8f622c3dbfd1f1536aaec3b6bb
ToppCellfacs-Mammary_Gland-Mammary_Gland-18m-Epithelial-luminal_epithelial_cell_of_mammary_gland|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABCC3 VWF INSRR SLC44A4 ELFN1

1.03e-0417511850992de1c7bffcb6890584357a7a0a8955927da6c
ToppCellfacs-Marrow-KLS-18m-Lymphocytic-late_pro-B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MMS22L EVPL CC2D1A ITGB4 DNAH11

1.06e-0417611853766e0533b103ec92ac75eba3df02e287efc53fa
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Ptprt_Pkp2|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

GLB1L2 ELFN1 AMOTL1 PKP2 PCDH8

1.06e-04176118505ec715439f2eb1696f5d8855da0dd1dd70effd0
ToppCellfacs-Marrow-KLS-18m-Lymphocytic-late_pro_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MMS22L EVPL CC2D1A ITGB4 DNAH11

1.06e-041761185aa1bada2175d8370fc71939a607407155259d195
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_ZNF322P1|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

FNDC1 ELFN1 PKP2 ARHGAP28 PCDH8

1.09e-04177118584116796ca4c7007508c0f1a68a1135c7b922278
ToppCellTCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Squamous_Cell_Carcinoma-5|TCGA-Lung / Sample_Type by Project: Shred V9

KRT5 KRT6A FRMD8 ARL4D KRT6C

1.09e-041771185a0c7d08469c513cecf87777c19876884f1511570
ToppCellCV-Severe-7|Severe / Virus stimulation, Condition and Cluster

MMS22L SUN1 SFI1 CEMIP2 TNKS

1.09e-04177118582fdd6185b368f54f03de389427cbe3071d21a99
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_GGH|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

VGF CCNG2 ELFN1 PKP2 PCDH8

1.09e-041771185d7976eac7e27044f6a859cc0c3398d08576e8c01
ToppCellPosterior_cortex-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_2|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

TNFSF13 INSRR SPTBN5 TRIM63

1.10e-04931184af489f0dd76c3c1a84d164283149f550a7ece91c
ToppCellPosterior_cortex-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_2-Endothelial_Tip.Dcn.Coch_(Coch)|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

TNFSF13 INSRR SPTBN5 TRIM63

1.10e-04931184c1d0afcfa37c2dcbb12189b4ce56ae7c4bb7ba30
ToppCellPosterior_cortex-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_2-Endothelial_Tip.Dcn.Coch_(Coch)-|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

TNFSF13 INSRR SPTBN5 TRIM63

1.10e-049311840ea74c2820372d60d3804bf2c8bb0d03733dff98
ToppCellfacs-Marrow-Granulocytes-3m-Lymphocytic-naive_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KRT5 KRT6A KHDRBS2 GLB1L2 AMOTL1

1.12e-0417811856d9ecfaeb50d562899380de379ebf7b99fd8adc9
ToppCellfacs-Marrow-Granulocytes-3m-Lymphocytic-naive_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KRT5 KRT6A KHDRBS2 GLB1L2 AMOTL1

1.12e-041781185d3f518cd75b02e85d45cbb9b2eff30f0272512a8
ToppCellfacs-Lung-18m-Endothelial-venous_endothelial-vein_endothelial_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

VWF ITGB4 CEMIP2 B4GALNT3 NOS3

1.12e-041781185ebfae386a518ea33911ba3ff40464c94d18ef695
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

FNDC1 ELFN1 PKP2 ARHGAP28 PCDH8

1.12e-0417811853c973aac16988e88f5677d3d695dd772ccfd6570
ToppCellfacs-Lung-18m-Endothelial-venous_endothelial-vein_endothelial_cell-vein_endothelial_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

VWF ITGB4 CEMIP2 B4GALNT3 NOS3

1.12e-041781185ccd37575b60102f5e647c01546e8ff8fec638bd7
ToppCellfacs-Lung-18m-Endothelial-venous_endothelial|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

VWF ITGB4 CEMIP2 B4GALNT3 NOS3

1.12e-04178118587b04753650e45f12299c8456fb980d6c0d5961c
ToppCellTCGA-Adrenal-Primary_Tumor-Pheochromocytoma-Pheochromocytoma-1|TCGA-Adrenal / Sample_Type by Project: Shred V9

GPLD1 CACNA1B PCLO INSRR ELAVL4

1.15e-041791185431e1b29015ec817f778499106d24b19cfc825ae
ToppCellfacs-Lung-24m-Endothelial-venous_endothelial-vein_endothelial_cell|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

VWF ITGB4 CEMIP2 ARL4D NOS3

1.18e-041801185178648429686e6d4e6f3aafc350130e819788ecf
ToppCellfacs-Lung-24m-Endothelial-venous_endothelial-vein_endothelial_cell-vein_endothelial_cell|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

VWF ITGB4 CEMIP2 ARL4D NOS3

1.18e-041801185fcd5d5bf00ee728162b0aac4c81eb78e742cf6f2
ToppCellfacs-Lung-24m-Endothelial-venous_endothelial|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

VWF ITGB4 CEMIP2 ARL4D NOS3

1.18e-041801185c2a8f61c806f6f6f47743e9f7c9700705db43386
ToppCellfacs-Lung-3m-Endothelial-venous_endothelial-vein_endothelial_cell-vein_endothelial_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

VWF ITGB4 CEMIP2 ARL4D NOS3

1.21e-04181118572c28baf4fd417ff4a7068603830d55074960144
DrugDicyclomine hydrochloride [67-92-5]; Down 200; 11.6uM; PC3; HT_HG-U133A

VGF CEACAM5 ARHGAP26 IRF5 PTPN21 ITGB4 ZNF783 CCNG2 BAHCC1

8.25e-0719511894581_DN
Drugplakin

KRT6A EVPL ITGB4 SPTBN5 KRT6C PLEC

4.33e-06821186CID000018752
Drugmant-GTP

KRT6A SUN1 ITGB4 KRT6C PLEC

6.04e-06501185CID000128647
DrugLevocabastine hydrochloride [79547-78-7]; Down 200; 8.8uM; MCF7; HT_HG-U133A

GLB1L2 STRN FASTK PLEC ZNF282 VPS53 TTC38 BAHCC1

7.90e-0619411883509_DN
DrugPrilocaine hydrochloride [1786-81-8]; Down 200; 15.6uM; PC3; HT_HG-U133A

ABCC3 INPP5K PIEZO1 ITGB4 ZNF783 PDE4DIP DCAF11 TTC38

7.90e-0619411884284_DN
Drug2-propylpentanoic acid; Down 200; 50uM; MCF7; HT_HG-U133A_EA

INPP5K ZNF212 TUSC3 IRF5 CEMIP2 PLEC ZNF282 PINK1

8.52e-0619611881002_DN
DrugChlorpheniramine maleate [113-92-8]; Down 200; 10.2uM; MCF7; HT_HG-U133A

ABCC3 TUSC3 CC2D1A IRF5 GLB1L2 HIF1AN PHKA2 PDE4DIP

8.84e-0619711886773_DN
DrugL(-)-vesamicol hydrochloride [112709-59-8]; Down 200; 13.6uM; MCF7; HT_HG-U133A

VGF RANBP10 CC2D1A IRF5 PHKA2 FASTK DCAF11 PINK1

9.18e-0619811885475_DN
Drugalpha-estradiol; Down 200; 0.01uM; ssMCF7; HG-U133A

RANBP10 SNX24 CCNG2 FASTK PDE4DIP PSMC3IP JRKL TP53BP1

9.52e-061991188403_DN
DrugTrifluoperazine dihydrochloride [440-17-5]; Up 200; 8.4uM; MCF7; HT_HG-U133A

INPP5K SUN1 IRF5 PTPN21 CCNG2 TTC38 RASAL1

4.33e-0518011877420_UP
DrugCaLam

ABCC3 KRT6A ABCB4 KRT6C

4.90e-05391184CID004126474
DrugLY 294002; Up 200; 10uM; MCF7; HT_HG-U133A

ABCC3 INPP5K SFI1 ITGB4 CCNG2 PDE4DIP PINK1

5.51e-0518711875224_UP
Drugwortmannin from Penicillium funiculosum; Up 200; 0.01uM; MCF7; HT_HG-U133A

ERCC2 INPP5K IQSEC2 KHDRBS2 CC2D1A CCNG2 DCAF11

6.30e-0519111876959_UP
DrugBeta-Escin [11072-93-8]; Down 200; 3.2uM; MCF7; HT_HG-U133A

ARHGAP26 IQSEC2 IRF5 SFI1 PTPN21 PDE4DIP PLEC

6.30e-0519111873890_DN
Drugphorbol 12-myristate

GPLD1 KRT5 KRT6A NAA15 NCF2 KRT6C LRBA PCDH8

6.61e-052611188CID000107854
DrugRapamycin; Up 200; 0.1uM; PC3; HT_HG-U133A

SFI1 PTPN21 ITGB4 CCNG2 PDE4DIP ARHGAP28 AMOTL2

6.73e-0519311874466_UP
DrugIndapamide [26807-65-8]; Down 200; 10.6uM; MCF7; HT_HG-U133A

INPP5K IQSEC2 SUN1 ARL4D PLEC TTC38 BAHCC1

6.95e-0519411873859_DN
DrugAdiphenine hydrochloride [50-42-0]; Up 200; 11.4uM; PC3; HT_HG-U133A

SNX24 ARHGAP26 CHD9 PTPN21 STRN AMOTL2 TTC38

7.18e-0519511871831_UP
DrugAC1L9LMC

KNTC1 KRT6A ITGB4 KRT6C PLEC

7.22e-05831185CID000448113
DrugZuclopenthixol hydrochloride [633-59-0]; Down 200; 9.2uM; MCF7; HT_HG-U133A

RNF25 ITGB4 DCAF11 PLEC VPS53 TTC38 BAHCC1

7.41e-0519611877356_DN
DrugBetonicine [515-25-3]; Down 200; 25.2uM; HL60; HT_HG-U133A

SFI1 ITGB4 HIF1AN ZNF783 ARL4D FASTK PDE4DIP

7.41e-0519611872207_DN
DrugPhenylpropanolamine hydrochloride [154-41-6]; Down 200; 21.4uM; MCF7; HT_HG-U133A

VGF INPP5K IQSEC2 SUN1 PHKA2 PINK1 BAHCC1

7.41e-0519611873217_DN
DrugFenofibrate [49562-28-9]; Up 200; 11uM; MCF7; HT_HG-U133A

RANBP10 SUN1 IRF5 PTPN21 CCNG2 PDE4DIP RASAL1

7.41e-0519611877432_UP
DrugMetoprolol-(+,-) (+)-tartrate salt [56392-17-7]; Up 200; 5.8uM; PC3; HT_HG-U133A

ARHGAP26 EVPL IRF5 SFI1 GLB1L2 PDE4DIP VPS53

7.41e-0519611874508_UP
DrugZardaverine [101975-10-4]; Down 200; 15uM; MCF7; HT_HG-U133A

ABCC3 INPP5K TUSC3 EVPL FASTK PLEC TTC38

7.65e-0519711877347_DN
DrugPNU-0251126 [267429-19-6]; Down 200; 1uM; MCF7; HT_HG-U133A

INPP5K IRF5 ZNF783 CCNG2 STRN PDE4DIP VPS53

7.65e-0519711874714_DN
Drugrosiglitazone; Up 200; 10uM; MCF7; HT_HG-U133A_EA

VGF RANBP10 SUN1 NCKIPSD PDE4DIP VPS53 PINK1

7.65e-0519711871013_UP
DrugHexylcaine hydrochloride [532-76-3]; Up 200; 13.4uM; MCF7; HT_HG-U133A

VGF ERCC2 ARL4D PHKA2 STRN PDE4DIP PINK1

7.65e-0519711873447_UP
DrugMethiazole; Down 200; 15uM; MCF7; HT_HG-U133A

ABCC3 EVPL FASTK PDE4DIP PLEC ZNF282 TTC38

7.65e-0519711874354_DN
DrugFolic acid [59-30-3]; Down 200; 9uM; MCF7; HT_HG-U133A

VGF CC2D1A IRF5 PTPN21 PHKA2 PLEC TP53BP1

7.65e-0519711877201_DN
DrugKynurenine, 3-hydroxy (R,S) [2147-61-7]; Up 200; 17.8uM; MCF7; HT_HG-U133A

ABCC3 IQSEC2 SFI1 ITGB4 DUOX1 PDE4DIP VPS53

7.65e-0519711872654_UP
DrugOxethazaine [126-27-2]; Down 200; 8.6uM; MCF7; HT_HG-U133A

VGF KNTC1 INPP5K ITGB4 CCNG2 PLEC TTC38

7.65e-0519711874829_DN
DrugAmitryptiline hydrochloride [549-18-8]; Down 200; 12.8uM; MCF7; HT_HG-U133A

VGF INPP5K PCLO NCKIPSD SFI1 JRKL RASAL1

7.65e-0519711875453_DN
Drug(cis-) Nanophine [5072-45-7]; Down 200; 26.8uM; MCF7; HT_HG-U133A

ERCC2 ZNF212 SUN1 EVPL ITGB4 ZNF783 PHKA2

7.65e-0519711874363_DN
DrugIndomethacin [53-86-1]; Down 200; 11.2uM; MCF7; HT_HG-U133A

ABHD14A INPP5K ZNF212 NCKIPSD PTPN21 STRN DCAF11

7.65e-0519711875468_DN
DrugMeropenem [96036-03-2]; Down 200; 10.4uM; MCF7; HT_HG-U133A

INPP5K RNF25 EVPL CC2D1A PTPN21 PHKA2 PLEC

7.90e-0519811877180_DN
DrugMelatonin [73-31-4]; Down 200; 17.2uM; MCF7; HT_HG-U133A

ABCC3 INPP5K ZNF783 SPTBN5 PDE4DIP PLEC TTC38

7.90e-0519811875393_DN
DrugIsometheptene mucate; Down 200; 8.2uM; MCF7; HT_HG-U133A

GPLD1 INPP5K KHDRBS2 SFI1 PTPN21 CCNG2 PDE4DIP

7.90e-0519811876524_DN
DrugPentetic acid [67-43-6]; Down 200; 10.2uM; PC3; HT_HG-U133A

ARHGAP26 IQSEC2 SUN1 CC2D1A PDE4DIP VPS53 TTC38

7.90e-0519811874669_DN
DrugPhenformin hydrochloride [834-28-6]; Up 200; 16.6uM; PC3; HT_HG-U133A

ABCC3 SFI1 ITGB4 ZNF783 CCNG2 PDE4DIP RASAL1

7.90e-0519811873725_UP
DrugTolfenamic acid [13710-19-5]; Down 200; 15.2uM; PC3; HT_HG-U133A

EVPL HIF1AN CEMIP2 ASB8 PDE4DIP DCAF11 TTC38

7.90e-0519811872120_DN
DrugICI 182,780; Up 200; 1uM; MCF7; HT_HG-U133A

ABCC3 PTPN21 ZNF783 CCNG2 STRN PDE4DIP TTC38

7.90e-0519811876965_UP
DrugPractolol [6673-35-4]; Down 200; 15uM; PC3; HT_HG-U133A

TUSC3 RNF25 PTPN21 ITGB4 HIF1AN CCNG2 PLEC

8.15e-0519911874603_DN
DrugZomepirac sodium salt [64092-48-4]; Down 200; 12.8uM; HL60; HT_HG-U133A

SUN1 SFI1 ITGB4 STRN PDE4DIP VPS53 BAHCC1

8.15e-0519911872713_DN
DrugBupropion hydrochloride [31677-93-7]; Up 200; 14.4uM; MCF7; HT_HG-U133A

PCLO IQSEC2 SUN1 CC2D1A ITGB4 HIF1AN SPTBN5

8.15e-0519911876256_UP
DrugAlfuzosin hydrochloride [81403-68-1]; Down 200; 9.4uM; MCF7; HT_HG-U133A

VGF IQSEC2 IRF5 PTPN21 PDE4DIP RASAL1 BAHCC1

8.15e-0519911873203_DN
DrugTolfenamic acid [13710-19-5]; Up 200; 15.2uM; MCF7; HT_HG-U133A

ERCC2 ARHGAP26 IQSEC2 SFI1 ABCB4 PKP2 TTC38

8.41e-0520011875454_UP
DrugDiazoxide [364-98-7]; Up 200; 17.4uM; HL60; HG-U133A

VGF CC2D1A NCF2 HIF1AN ZNF783 FASTK RASAL1

8.41e-0520011871368_UP
DrugAC1L1R04

KNTC1 EVPL ELAVL4 PLEC

1.03e-04471184CID000008439
DrugNSC648766

ABCC3 ERCC2 ABCB4 CCNG2 PLEC

1.24e-04931185CID000003199
DrugD-alanyl-D-lactate

TRIM55 TRIM63

1.59e-0441182CID005487001
DrugMMTP

INSRR MTTP

1.59e-0441182CID000018391
Diseasevisceral heterotaxy (implicated_via_orthology)

CC2D1A PHKA2 DNAAF3 DNAH11

1.40e-05371174DOID:0050545 (implicated_via_orthology)
DiseaseJunctional epidermolysis bullosa with pyloric atresia

ITGB4 PLEC

1.56e-0521172cv:C5676875
DiseaseEpidermolysis Bullosa Simplex With Pyloric Atresia

ITGB4 PLEC

1.56e-0521172C2677349
DiseaseEPIDERMOLYSIS BULLOSA, JUNCTIONAL 5B, WITH PYLORIC ATRESIA

ITGB4 PLEC

1.56e-0521172226730
DiseaseEpidermolysis bullosa with pyloric atresia

ITGB4 PLEC

4.66e-0531172C1856934
DiseaseEpidermolysis Bullosa Herpetiformis Dowling-Meara

KRT5 ITGB4

4.66e-0531172C0079295
DiseaseEpidermolysis Bullosa Simplex Kobner

KRT5 ITGB4

4.66e-0531172C0079299
DiseaseWeber-Cockayne Syndrome

KRT5 ITGB4

4.66e-0531172C0080333
DiseaseEpidermolysis Bullosa

KRT5 ITGB4

9.30e-0541172C0014527
DiseaseGlycogen phosphorylase kinase deficiency

PHKA1 PHKA2

9.30e-0541172cv:C0268147
DiseaseEpidermolysis Bullosa Simplex

KRT5 ITGB4

1.55e-0451172C0079298
DiseaseAplasia Cutis Congenita

ITGB4 PLEC

2.31e-0461172C0282160
Diseaseseptic shock

MMS22L ARHGAP26

3.23e-0471172EFO_0006834
Diseaseepidermolysis bullosa simplex (is_implicated_in)

KRT5 PLEC

3.23e-0471172DOID:4644 (is_implicated_in)
Diseasediverticular disease

MMS22L SNX24 PIEZO1 NOTUM ELFN1 PKP2

3.67e-042361176EFO_0009959
DiseasePrimary ciliary dyskinesia

DNAAF3 CCDC40 DNAH11

3.94e-04361173cv:C0008780
Diseaseglycogen storage disease (is_implicated_in)

PHKA1 PHKA2

5.51e-0491172DOID:2747 (is_implicated_in)
DiseasePrimary Ciliary Dyskinesia

DNAAF3 CCDC40 DNAH11

8.68e-04471173C4551720
DiseasePrimary biliary cirrhosis

IRF5 ABCB4 NOS3

8.68e-04471173C0008312
Diseasecholestasis (biomarker_via_orthology)

ABCC3 ABCB4 NOS3

9.80e-04491173DOID:13580 (biomarker_via_orthology)
Diseasedisease recurrence, colon carcinoma

ZNF767P ZNF746 AMOTL1

1.10e-03511173EFO_0004952, EFO_1001950
Diseasehypothyroidism (implicated_via_orthology)

PHKA1 DUOX1

1.18e-03131172DOID:1459 (implicated_via_orthology)
Diseasehippocampal volume

PARD3B ITPRID1 STRN ZNF398 PLEC DNAH11

1.22e-032971176EFO_0005035
DiseaseKartagener syndrome (implicated_via_orthology)

DNAAF3 DNAH11

1.38e-03141172DOID:0050144 (implicated_via_orthology)
Diseasebrain measurement, neuroimaging measurement

SNX24 HIF1AN DNAAF3 STRN SSH2 PLEC BAHCC1 DNAH11

1.60e-035501178EFO_0004346, EFO_0004464
DiseasePontoneocerebellar hypoplasia

PCLO VPS53

1.80e-03161172cv:C1261175
DiseaseGlycogen storage disease

PHKA1 PHKA2

2.04e-03171172cv:C0017919
DiseaseGastric ulcer

VGF NOS3

2.29e-03181172C0038358
Diseasefamilial hyperlipidemia (biomarker_via_orthology)

MTTP NOS3

2.55e-03191172DOID:1168 (biomarker_via_orthology)
DiseaseCholecystitis

ABCB4 LRBA

2.55e-03191172HP_0001082
Diseaseautism spectrum disorder (implicated_via_orthology)

NAA15 CHD9 PKP2 LRBA

3.20e-031521174DOID:0060041 (implicated_via_orthology)
Diseaseplatelet-to-lymphocyte ratio

KNTC1 RANBP10 VWF IP6K3 STRN PLEC

3.31e-033631176EFO_0008446
DiseaseBronchiectasis

CCDC40 DNAH11

3.42e-03221172C0006267
DiseaseParoxysmal atrial fibrillation

VWF SUN1 PKP2 NOS3

3.51e-031561174C0235480
Diseasefamilial atrial fibrillation

VWF SUN1 PKP2 NOS3

3.51e-031561174C3468561
DiseasePersistent atrial fibrillation

VWF SUN1 PKP2 NOS3

3.51e-031561174C2585653
Diseaseasparaginase hypersensitivity

CACNA1B IP6K3 ARHGAP28

3.59e-03771173EFO_0004881
Diseasesphingomyelin 24:1 measurement

MMS22L TUSC3

3.73e-03231172EFO_0010398
DiseaseAtrial Fibrillation

VWF SUN1 PKP2 NOS3

3.84e-031601174C0004238

Protein segments in the cluster

PeptideGeneStartEntry
LNRDDIGIILINQYI

ATP6V1F

56

Q16864
GIRLNLILIRYTGDN

ABHD13

96

Q7L211
QLQRLAEELRRGYQE

CEP295NL

106

Q96MC4
VLHRLIQEQLRYGNL

AMOTL2

11

Q9Y2J4
IVIEGERGNRQRIYS

BAHCC1

1941

Q9P281
QVLQLGYNRLRNLTE

ELFN1

111

P0C7U0
RLQEVYRQQREAVLG

CCDC187

671

A0A096LP49
GRDRIVFGNIQQIYE

ARHGEF25

201

Q86VW2
VDGLGLQQGLERLYE

ARL4D

171

P49703
QDQLRGGRYLLELEL

B4GALNT3

701

Q6L9W6
GGRYLLELELLEQGQ

B4GALNT3

706

Q6L9W6
ERVDGNRQIIGYVIG

CEACAM5

71

P06731
EGEGYINLNQVRRRD

C4orf47

71

A7E2U8
QLLGLLNVYLEQEER

CCNG2

16

Q16589
GIQELRVDLANLYIR

DNAH11

2886

Q96DT5
GTVLQRLIQEQLRYG

AMOTL1

96

Q8IY63
ASLNGYRLGDRVLQV

ELAVL4

361

P26378
RRQQQIERELNGYLE

CACNA1B

376

Q00975
LLQQGQERLVERYHG

ABHD16B

126

Q9H3Z7
AQTVYRQLLLGRDQL

RASAL1

726

O95294
RELQALSEQLGREYG

RANBP10

516

Q6VN20
LNRLVTGIDNYGQGR

INTS6

101

Q9UL03
GIRQGELQLLRTAAY

ABCC3

516

O15438
QRAAIILGYRIQGVI

KIAA1549

1266

Q9HCM3
EQLGTLQLLSQRGYR

ABHD14A

111

Q9BUJ0
LDYGAEVRVINLIGQ

ASB8

171

Q9H765
AILREGALYQRQVEQ

CFAP99

301

D6REC4
GALYQRQVEQELQRV

CFAP99

306

D6REC4
VYLQPGQIRVVDGRL

DUOX1

661

Q9NRD9
AEGLRQLLGEEKYRQ

FASTK

406

Q14296
LRVGELTQQALQRYL

PARD3B

21

Q8TEW8
QYINNLRRQLDSIVG

KRT6C

216

P48668
GAAGILLRYLQEQNR

PSMC3IP

11

Q9P2W1
LRGNQLIDYKILGLQ

NCF2

101

P19878
FQLGDRAQQIREGIL

ITPRID1

926

Q6ZRS4
QQRGGEERLYLQQTL

HIF1AN

136

Q9NWT6
QYINNLRRQLDSIVG

KRT6A

216

P02538
QLLGNVIEQYIGRFL

MMS22L

1021

Q6ZRQ5
GEQGLLNAYRQVQEV

FRMD8

226

Q9BZ67
NSGVRLDGYARLVQQ

PHKA1

6

P46020
RDLLVGIYQRIQGRE

IQSEC2

926

Q5JU85
GIYQRIQGRELRTND

IQSEC2

931

Q5JU85
QYINNLRRQLDSIVG

KRT5

221

P13647
GEIQLQINYDLGNLI

PCLO

4696

Q9Y6V0
RRLQGFRLEEYLIGQ

PINK1

146

Q9BXM7
GILRRSNLNIFQYIG

MTTP

641

P55157
LGRNGQVTYRLLEAE

PCDH8

526

O95206
VIRGLGVQLLEQVYD

NEK4

786

P51957
GIIDRGQYLQLQELE

EVPL

1706

Q92817
DLAQVLAYLLRRGQV

DCAF11

41

Q8TEB1
LAYLLRRGQVRLVQG

DCAF11

46

Q8TEB1
ALQRAYALLQEQVGG

JAKMIP3

511

Q5VZ66
NIRAIQLSRDGQYLL

LRBA

2781

P50851
REDIAVIRNYGNLLL

ERCC2

511

P18074
LRGYGIREVNLLNKE

KNTC1

846

P50748
RNYRAGLLQNNLEEG

JRKL

336

Q9Y4A0
LDRGLILQLQGQDLY

IRF5

321

Q13568
GNIGLVALIYIEQRL

OR5K3

41

A6NET4
RRGEVGIYQVQLRAL

ITGB4

401

P16144
GYIFGLENLIRILQD

IP6K3

391

Q96PC2
ELLLYQNQVLREAGL

NAA15

191

Q9BXJ9
QNQVLREAGLYREAL

NAA15

196

Q9BXJ9
DRIVAYRLGIRQAGQ

MDGA2

666

Q7Z553
GRYQIINGLRRFEIE

SMPD4

711

Q9NXE4
RNFNVNYLREIIGVV

ABCB4

461

P21439
EAGDVIGVLRDQQRY

NOS3

1141

P29474
AQIDLNGRIRNGSVY

PTPN21

381

Q16825
ALGDYARVEQRLGQL

PRR35

411

P0CG20
VQEGLRLYIQNLGRE

NOTUM

356

Q6P988
LQERRNVGANGIGYQ

CSGALNACT2

96

Q8N6G5
ALGQQQYLTRLRELQ

CHD9

2376

Q3L8U1
LARYLVDVRQEQLQG

DNAAF3

411

Q8N9W5
DRGLVLNAEGRYLQD

FNDC1

1361

Q4ZHG4
NLGLIIFRDQVVRYG

CUL3

141

Q13618
RNLNLDIYVIGLQEL

INPP5K

41

Q9BT40
RAQRQELGVNLYEVQ

CCDC40

321

Q4G0X9
RAQLEQGGVGIRREY

CC2D1A

891

Q6P1N0
QERLGSELIQGLGYR

CEMIP2

331

Q9UHN6
QERVLAQLRAALYGI

CCP110

856

O43303
EGSLILNLRQGYNLE

INSRR

351

P14616
EIRQEQLRELSYLNG

KHDRBS2

166

Q5VWX1
QRSVFNLQIYGVLGL

SLC44A4

436

Q53GD3
LHRIYLRGRNEEQGI

DCK

186

P27707
QGYTVLRILVENRGR

GLB1L2

476

Q8IW92
LRILVENRGRVNYGE

GLB1L2

481

Q8IW92
NSGVRLDGYARLVQQ

PHKA2

6

P46019
YQGQLLQEGATRLLR

SFI1

881

A8K8P3
KQGRQLLRQYLQEVG

STRN

156

O43815
LLLQYLLQGGARQRG

VGF

331

O15240
ETRGINEQGLYRIVG

ARHGAP26

401

Q9UNA1
NEQGLYRIVGVNSRV

ARHGAP26

406

Q9UNA1
AYLRRLQGLEQDVLQ

NCKIPSD

51

Q9NZQ3
GNLLRYQQQLEGALE

SPTBN5

2351

Q9NRC6
GLQRNLLVENIIDIY

TRIM63

91

Q969Q1
VLGTLLQEYGLLQRR

ZNF767P

66

Q75MW2
LQEYGLLQRRLENVE

ZNF767P

71

Q75MW2
GVYGLQRNLLVENII

TRIM54

91

Q9BYV2
LLEAIVQRYQQGRGA

TRIM67

181

Q6ZTA4
VGGLLYLRRNNLEFI

TUSC3

211

Q13454
ALQQALNERDGLYGR

TEX13D

131

A0A0J9YY54
LNERDGLYGRLLQIE

TEX13D

136

A0A0J9YY54
GVYGLQRNLLVENII

TRIM55

91

Q9BYV6
RYAEAVQLLGGELQR

TTC30B

26

Q8N4P2
TLVIQQRGVRIYDGE

VPS36

16

Q86VN1
ILQRVREIRYQGGNR

VWF

1561

P04275
LEQRRQGLETYLQAV

SNX24

71

Q9Y343
LEDLQNRGVRYILNV

SSH2

326

Q76I76
IQNQRLYEIGGNIGE

ARHGAP28

686

Q9P2N2
LYQRQQERGGIIDLE

RNF25

241

Q96BH1
AAGYNRVRIVQLLLQ

TNKS

376

O95271
TLLQEYGLLQRRLEN

ZNF398

101

Q8TD17
QLHNGRVNYRELLLE

GPLD1

41

P80108
IIDLIYLNGLRNEGR

TTLL2

411

Q9BWV7
VILSLEQGNRLREQY

TP53BP1

1586

Q12888
RDGRVAQLEQVYIRG

SNRPD3

51

P62318
SRVIDRELYQQLQRG

PLEC

3126

Q15149
TRRRQYGEVANLLQG

VPS53

166

Q5VIR6
LEQRRQGLEAYIQGI

SNX22

76

Q96L94
LRVGLQRYLQGSSVQ

VASN

476

Q6EMK4
IRYRIVQLGGSNAQR

TTC38

401

Q5R3I4
VLGTLLQEYGLLQRR

ZNF212

96

Q9UDV6
LQEYGLLQRRLENVE

ZNF212

101

Q9UDV6
DYLGVRIQLRREQGA

PIEZO1

2381

Q92508
YFLLQILRRIGAVGQ

SUN1

221

O94901
VLGTLLQEYGLLQRR

ZNF746

66

Q6NUN9
LQEYGLLQRRLENVE

ZNF746

71

Q6NUN9
REQQVRLIYQGQLLG

TMUB1

136

Q9BVT8
GYIRTVLGQQILGQL

PKP2

11

Q99959
RGLQAQGYGVRIQDA

TNFSF13

146

O75888
TLLQEYGLLQRRLEN

ZNF282

156

Q9UDV7
TLLQEYGLLQRRLEN

ZNF783

101

Q6ZMS7
YGLLQRRLENVENLL

ZNF783

106

Q6ZMS7
ELQALRQYLGGRDSL

PDE4DIP

676

Q5VU43