Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	GTPase activator activity	TBC1D3E ARHGEF19 TBC1D3 TBC1D3H TBC1D3L TBC1D3D ARHGAP27 TBC1D3I TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F	1.51e-10	279	84	13	GO:0005096
GeneOntologyMolecularFunction	nucleoside-triphosphatase regulator activity	TBC1D3E ARHGEF19 TBC1D3 TBC1D3H TBC1D3L TBC1D3D ARHGAP27 TBC1D3I TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F	1.89e-07	507	84	13	GO:0060589
GeneOntologyMolecularFunction	GTPase regulator activity	TBC1D3E ARHGEF19 TBC1D3 TBC1D3H TBC1D3L TBC1D3D ARHGAP27 TBC1D3I TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F	1.89e-07	507	84	13	GO:0030695
GeneOntologyMolecularFunction	enzyme activator activity	TBC1D3E ARHGEF19 TBC1D3 TBC1D3H TBC1D3L TBC1D3D BAD ARHGAP27 TBC1D3I TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F	5.64e-07	656	84	14	GO:0008047
GeneOntologyMolecularFunction	enzyme regulator activity	TBC1D3E ARHGEF19 TBC1D3 TBC1D3H TBC1D3L TBC1D3D PPP1R15B BAD PAPLN SMO ARHGAP27 TBC1D3I TBC1D3G SSPOP TBC1D3C TBC1D3B HSPB1 TBC1D3K TBC1D3F	5.12e-06	1418	84	19	GO:0030234
GeneOntologyMolecularFunction	steroid 11-beta-monooxygenase activity	CYP11B1 CYP11B2	1.75e-05	2	84	2	GO:0004507
GeneOntologyMolecularFunction	corticosterone 18-monooxygenase activity	CYP11B1 CYP11B2	1.75e-05	2	84	2	GO:0047783
GeneOntologyMolecularFunction	heme binding	MPO CYP11B1 CYP11B2 CYP27B1 DUOX2	4.83e-04	154	84	5	GO:0020037
GeneOntologyMolecularFunction	molecular function activator activity	TBC1D3E ARHGEF19 TBC1D3 TBC1D3H TBC1D3L TBC1D3D BAD ARHGAP27 TBC1D3I TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F	5.92e-04	1233	84	14	GO:0140677
GeneOntologyMolecularFunction	tetrapyrrole binding	MPO CYP11B1 CYP11B2 CYP27B1 DUOX2	6.43e-04	164	84	5	GO:0046906
GeneOntologyMolecularFunction	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen	CYP11B1 CYP11B2	1.32e-03	13	84	2	GO:0016713
GeneOntologyBiologicalProcess	activation of GTPase activity	TBC1D3E ARHGEF19 TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3I TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F	2.43e-14	109	85	12	GO:0090630
GeneOntologyBiologicalProcess	positive regulation of GTPase activity	TBC1D3E ARHGEF19 TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3I TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F	3.52e-10	244	85	12	GO:0043547
GeneOntologyBiologicalProcess	regulation of GTPase activity	TBC1D3E ARHGEF19 TBC1D3 TBC1D3H TBC1D3L TBC1D3D ARHGAP27 TBC1D3I TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F	1.12e-09	335	85	13	GO:0043087
GeneOntologyBiologicalProcess	positive regulation of hydrolase activity	TBC1D3E ARHGEF19 LMF1 TBC1D3 TBC1D3H TBC1D3L TBC1D3D PPP1R15B BAD TBC1D3I TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F	1.76e-09	499	85	15	GO:0051345
GeneOntologyBiologicalProcess	regulation of hydrolase activity	TBC1D3E BCL2L12 ARHGEF19 LMF1 TBC1D3 TBC1D3H TBC1D3L TBC1D3D PPP1R15B BAD PAPLN ARHGAP27 TBC1D3I TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F	1.45e-08	878	85	18	GO:0051336
GeneOntologyBiologicalProcess	positive regulation of catalytic activity	TBC1D3E ARHGEF19 LMF1 TBC1D3 TBC1D3H TBC1D3L TBC1D3D PPP1R15B CYP27B1 BAD TBC1D3I TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F	3.96e-06	1028	85	16	GO:0043085
GeneOntologyBiologicalProcess	amino-acid betaine catabolic process	DMGDH BHMT	5.02e-05	3	85	2	GO:0006579
GeneOntologyBiologicalProcess	positive regulation of molecular function	TGFBR3 TBC1D3E ARHGEF19 LMF1 TBC1D3 TBC1D3H TBC1D3L TBC1D3D PPP1R15B CYP27B1 BAD TBC1D3I TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F	6.29e-05	1430	85	17	GO:0044093
GeneOntologyBiologicalProcess	regulation of blood volume by renal aldosterone	CYP11B1 CYP11B2	1.00e-04	4	85	2	GO:0002017
MousePheno	abnormal urine progesterone level	CYP11B1 CYP11B2	1.46e-05	2	54	2	MP:0011545
MousePheno	abnormal urine deoxycorticosterone level	CYP11B1 CYP11B2	1.46e-05	2	54	2	MP:0011552
MousePheno	decreased urine corticosterone level	CYP11B1 CYP11B2	1.46e-05	2	54	2	MP:0011550
MousePheno	increased urine deoxycorticosterone level	CYP11B1 CYP11B2	1.46e-05	2	54	2	MP:0011553
MousePheno	increased urine progesterone level	CYP11B1 CYP11B2	1.46e-05	2	54	2	MP:0011546
MousePheno	abnormal adrenal gland zona glomerulosa morphology	CYP11B1 CYP11B2	8.74e-05	4	54	2	MP:0008293
MousePheno	decreased urine aldosterone level	CYP11B1 CYP11B2	8.74e-05	4	54	2	MP:0011541
MousePheno	abnormal urine aldosterone level	CYP11B1 CYP11B2	8.74e-05	4	54	2	MP:0011539
MousePheno	abnormal urine corticosterone level	CYP11B1 CYP11B2	8.74e-05	4	54	2	MP:0011548
MousePheno	decreased urine hormone level	CYP11B1 CYP11B2	8.74e-05	4	54	2	MP:0014459
MousePheno	increased adrenal gland zona fasciculata size	CYP11B1 CYP11B2	1.45e-04	5	54	2	MP:0014286
MousePheno	uterus adenomyosis	CYP11B1 CYP11B2	2.18e-04	6	54	2	MP:0009221
MousePheno	increased urine hormone level	CYP11B1 CYP11B2	2.18e-04	6	54	2	MP:0014458
MousePheno	adrenal gland hyperplasia	CYP11B1 CYP11B2	2.18e-04	6	54	2	MP:0009078
MousePheno	abnormal urine hormone level	CYP11B1 CYP11B2	3.04e-04	7	54	2	MP:0011538
MousePheno	pituitary gland hyperplasia	CYP11B1 CYP11B2	3.04e-04	7	54	2	MP:0000635
MousePheno	decreased thymus weight	CYP11B1 CYP11B2 BAD	3.55e-04	36	54	3	MP:0004956
MousePheno	increased circulating angiotensin II level	CYP11B1 CYP11B2	4.04e-04	8	54	2	MP:0031232
MousePheno	increased angiotensin II level	CYP11B1 CYP11B2	4.04e-04	8	54	2	MP:0031229
MousePheno	decreased circulating renin level	CYP11B1 CYP11B2	6.46e-04	10	54	2	MP:0003353
MousePheno	abnormal adrenocortical cell morphology	CYP11B1 CYP11B2	6.46e-04	10	54	2	MP:0008291
MousePheno	abnormal adrenal gland zona fasciculata size	CYP11B1 CYP11B2	7.88e-04	11	54	2	MP:0014284
MousePheno	uterus cyst	CYP11B1 CYP11B2	7.88e-04	11	54	2	MP:0009082
MousePheno	increased circulating pituitary hormone level	C14orf93 CYP11B1 CYP11B2 DUOX2	8.48e-04	110	54	4	MP:0005117
MousePheno	abnormal endometrium morphology	CYP11B1 CYP11B2 CYP27B1	8.85e-04	49	54	3	MP:0004896
MousePheno	abnormal circulating angiotensin II level	CYP11B1 CYP11B2	9.43e-04	12	54	2	MP:0031230
MousePheno	abnormal angiotensin II level	CYP11B1 CYP11B2	9.43e-04	12	54	2	MP:0031227
MousePheno	hypokalemia	CYP11B1 CYP11B2	9.43e-04	12	54	2	MP:0004119
MousePheno	enlarged pituitary gland	CYP11B1 CYP11B2	9.43e-04	12	54	2	MP:0000636
MousePheno	abnormal corpus luteum morphology	YBX2 CYP11B1 CYP11B2 CYP27B1	1.03e-03	116	54	4	MP:0002679
MousePheno	increased renin activity	CYP11B1 CYP11B2	1.29e-03	14	54	2	MP:0005582
MousePheno	decreased circulating mineralocorticoid level	CYP11B1 CYP11B2	1.29e-03	14	54	2	MP:0003374
MousePheno	increased urine osmolality	CYP11B1 CYP11B2	1.29e-03	14	54	2	MP:0008055
MousePheno	increased circulating adrenocorticotropin level	CYP11B1 CYP11B2	1.29e-03	14	54	2	MP:0001748
MousePheno	decreased circulating aldosterone level	CYP11B1 CYP11B2	1.29e-03	14	54	2	MP:0002667
MousePheno	endometrium hyperplasia	CYP11B1 CYP11B2	1.29e-03	14	54	2	MP:0009092
MousePheno	abnormal amino acid derivative level	C14orf93 C6orf89 DUOX2 BHMT	1.36e-03	125	54	4	MP:0021145
Domain	TBC	TBC1D3E TBC1D3H TBC1D3L TBC1D3D TBC1D3I TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F	8.34e-15	49	80	10	SM00164
Domain	RabGAP-TBC	TBC1D3E TBC1D3H TBC1D3L TBC1D3D TBC1D3I TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F	1.95e-14	53	80	10	PF00566
Domain	TBC_RABGAP	TBC1D3E TBC1D3H TBC1D3L TBC1D3D TBC1D3I TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F	2.91e-14	55	80	10	PS50086
Domain	Rab-GTPase-TBC_dom	TBC1D3E TBC1D3H TBC1D3L TBC1D3D TBC1D3I TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F	2.91e-14	55	80	10	IPR000195
Domain	DUF4939	RTL8B RTL8A RTL8C	8.89e-06	10	80	3	PF16297
Domain	DUF4939	RTL8B RTL8A RTL8C	8.89e-06	10	80	3	IPR032549
Domain	LDOC1-rel	RTL8B RTL8A RTL8C	1.22e-05	11	80	3	IPR032567
Domain	Cyt_P450_mitochondrial	CYP11B1 CYP11B2	1.81e-05	2	80	2	IPR002399
Domain	MAGE	TRO MAGEB18 MAGEB17	4.11e-04	34	80	3	SM01373
Domain	MAGE	TRO MAGEB18 MAGEB17	4.88e-04	36	80	3	PS50838
Domain	MAGE	TRO MAGEB18 MAGEB17	4.88e-04	36	80	3	PF01454
Domain	MHD_dom	TRO MAGEB18 MAGEB17	4.88e-04	36	80	3	IPR002190
Domain	Haem_peroxidase	MPO DUOX2	7.97e-04	10	80	2	IPR010255
Domain	An_peroxidase	MPO DUOX2	7.97e-04	10	80	2	PF03098
Domain	PEROXIDASE_3	MPO DUOX2	7.97e-04	10	80	2	PS50292
Domain	Haem_peroxidase_animal	MPO DUOX2	7.97e-04	10	80	2	IPR019791
Domain	-	MPO DUOX2	7.97e-04	10	80	2	1.10.640.10
Domain	Cyt_P450_CS	CYP11B1 CYP11B2 CYP27B1	1.52e-03	53	80	3	IPR017972
Domain	CYTOCHROME_P450	CYP11B1 CYP11B2 CYP27B1	1.87e-03	57	80	3	PS00086
Domain	-	CYP11B1 CYP11B2 CYP27B1	1.97e-03	58	80	3	1.10.630.10
Domain	p450	CYP11B1 CYP11B2 CYP27B1	1.97e-03	58	80	3	PF00067
Domain	Cyt_P450	CYP11B1 CYP11B2 CYP27B1	2.17e-03	60	80	3	IPR001128
Domain	MAGE_N	MAGEB18 MAGEB17	3.27e-03	20	80	2	SM01392
Domain	EPHD	KMT2D BRD1	3.96e-03	22	80	2	PS51805
Domain	MAGE_N	MAGEB18 MAGEB17	3.96e-03	22	80	2	PF12440
Domain	MAGE_N	MAGEB18 MAGEB17	3.96e-03	22	80	2	IPR021072
Pathway	WP_17Q12_COPY_NUMBER_VARIATION_SYNDROME	TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3I TBC1D3G TBC1D3C TBC1D3B TBC1D3K	4.67e-11	99	49	9	M46448
Pathway	KEGG_MEDICUS_REFERENCE_STEROID_HORMONE_BIOSYNTHESIS_PROGESTERONE_TO_CORTISOL_CORTISONE	CYP11B1 CYP11B2	1.18e-04	5	49	2	M47522
Pathway	REACTOME_CHOLINE_CATABOLISM	DMGDH BHMT	1.76e-04	6	49	2	M27619
Pathway	REACTOME_CHOLINE_CATABOLISM	DMGDH BHMT	1.76e-04	6	49	2	MM15329
Pathway	REACTOME_METABOLIC_DISORDERS_OF_BIOLOGICAL_OXIDATION_ENZYMES	CYP11B1 CYP11B2 CYP27B1	2.19e-04	34	49	3	M27461
Pathway	WP_OXIDATION_BY_CYTOCHROME_P450	CYP11B1 CYP11B2 CYP27B1	4.42e-04	43	49	3	MM15873
Pathway	REACTOME_GLUCOCORTICOID_BIOSYNTHESIS	CYP11B1 CYP11B2	5.23e-04	10	49	2	M27076
Pathway	REACTOME_GLUCOCORTICOID_BIOSYNTHESIS	CYP11B1 CYP11B2	6.38e-04	11	49	2	MM14750
Pathway	REACTOME_MINERALOCORTICOID_BIOSYNTHESIS	CYP11B1 CYP11B2	7.64e-04	12	49	2	MM14749
Pubmed	TBC1D3, a hominoid oncoprotein, is encoded by a cluster of paralogues located on chromosome 17q12.	TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3I TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F	1.09e-29	11	86	11	16863688
Pubmed	DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.	TBC1D3E TBC1D3 TBC1D3H TBC1D3D TBC1D3G TBC1D3B TBC1D3F	6.93e-10	74	86	7	16625196
Pubmed	A low-copy repeat in Xq26 represents a novel putatively prenylated protein gene (CXX1) and its pseudogenes (DXS9914, DXS9915, and DXS9916).	RTL8B RTL8A RTL8C	1.46e-08	3	86	3	9403077
Pubmed	PRC17, a novel oncogene encoding a Rab GTPase-activating protein, is amplified in prostate cancer.	TBC1D3 TBC1D3D TBC1D3F	5.83e-08	4	86	3	12359748
Pubmed	Identification of novel sequences in the repertoire of hypervariable TRE17 genes from immortalized nonmalignant and malignant human keratinocytes.	TBC1D3 TBC1D3D TBC1D3F	5.83e-08	4	86	3	8406013
Pubmed	The Tre2 (USP6) oncogene is a hominoid-specific gene.	TBC1D3 TBC1D3D TBC1D3C	1.45e-07	5	86	3	12604796
Pubmed	Human TRE17 oncogene is generated from a family of homologous polymorphic sequences by single-base changes.	TBC1D3 TBC1D3D TBC1D3F	1.45e-07	5	86	3	8471161
Pubmed	RTL8 promotes nuclear localization of UBQLN2 to subnuclear compartments associated with protein quality control.	RTL8B RTL8A RTL8C	2.90e-07	6	86	3	35247097
Pubmed	Polymorphisms located in the region containing BHMT and BHMT2 genes as maternal protective factors for orofacial clefts.	DMGDH PCYT1A BHMT	5.07e-07	7	86	3	20662904
Pubmed	A family of neofunctionalized Ty3/gypsy retrotransposon genes in mammalian genomes.	RTL8B RTL8A RTL8C	2.37e-06	11	86	3	16093683
Pubmed	Transposable elements as a source of genetic innovation: expression and evolution of a family of retrotransposon-derived neogenes in mammals.	RTL8B RTL8A RTL8C	2.37e-06	11	86	3	15716091
Pubmed	Shh signaling regulates adrenocortical development and identifies progenitors of steroidogenic lineages.	CYP11B1 CYP11B2 SMO	5.21e-06	14	86	3	19955443
Pubmed	Phenotypic consequences of variation across the aldosterone synthase and 11-beta hydroxylase locus in a hypertensive cohort: data from the MRC BRIGHT Study.	CYP11B1 CYP11B2	6.04e-06	2	86	2	17651452
Pubmed	Common polymorphisms in the CYP11B1 and CYP11B2 genes: evidence for a digenic influence on hypertension.	CYP11B1 CYP11B2	6.04e-06	2	86	2	23150505
Pubmed	Expression of CYP11B1 and CYP11B2 in adrenal adenoma correlates with clinical characteristics of primary aldosteronism.	CYP11B1 CYP11B2	6.04e-06	2	86	2	34743356
Pubmed	GRAde: a long-read sequencing approach to efficiently identifying the CYP11B1/CYP11B2 chimeric form in patients with glucocorticoid-remediable aldosteronism.	CYP11B1 CYP11B2	6.04e-06	2	86	2	35012455
Pubmed	Role of genetic variation in regulation of aldosterone biosynthesis.	CYP11B1 CYP11B2	6.04e-06	2	86	2	21164264
Pubmed	Polymorphisms in CYP11B2 and CYP11B1 genes associated with primary hyperaldosteronism.	CYP11B1 CYP11B2	6.04e-06	2	86	2	20339375
Pubmed	Genetic analyses of the chimeric CYP11B1/CYP11B2 gene in a Korean family with glucocorticoid-remediable aldosteronism.	CYP11B1 CYP11B2	6.04e-06	2	86	2	20808686
Pubmed	The hamster adrenal cytochrome P450C11 has equipotent 11beta-hydroxylase and 19-hydroxylase activities, but no aldosterone synthase activity.	CYP11B1 CYP11B2	6.04e-06	2	86	2	8645611
Pubmed	Expression and localization of cytochrome P450(11beta,aldo) mRNA in the frog brain.	CYP11B1 CYP11B2	6.04e-06	2	86	2	12231255
Pubmed	A de novo unequal cross-over mutation between CYP11B1 and CYP11B2 genes causes familial hyperaldosteronism type I.	CYP11B1 CYP11B2	6.04e-06	2	86	2	20634641
Pubmed	Hereditary hypertension caused by chimaeric gene duplications and ectopic expression of aldosterone synthase.	CYP11B1 CYP11B2	6.04e-06	2	86	2	1303253
Pubmed	Aldosterone decreases glucose-stimulated insulin secretion in vivo in mice and in murine islets.	CYP11B1 CYP11B2	6.04e-06	2	86	2	21519965
Pubmed	Diagnosis of glucocorticoid-remediable aldosteronism in hypertensive children.	CYP11B1 CYP11B2	6.04e-06	2	86	2	21625068
Pubmed	Genetic screening for glucocorticoid-remediable aldosteronism (GRA): experience of three clinical centres in Poland.	CYP11B1 CYP11B2	6.04e-06	2	86	2	16110193
Pubmed	Chimeric CYP11B2/CYP11B1 causing 11β-hydroxylase deficiency in Chinese patients with congenital adrenal hyperplasia.	CYP11B1 CYP11B2	6.04e-06	2	86	2	26066897
Pubmed	Role of steroid 11 beta-hydroxylase and steroid 18-hydroxylase in the biosynthesis of glucocorticoids and mineralocorticoids in humans.	CYP11B1 CYP11B2	6.04e-06	2	86	2	1741400
Pubmed	Effects of intron conversion in the human CYP11B2 gene on its transcription and blood pressure regulation in transgenic mice.	CYP11B1 CYP11B2	6.04e-06	2	86	2	32540969
Pubmed	Inhibition of aldosterone synthase (CYP11B2) by torasemide prevents atrial fibrosis and atrial fibrillation in mice.	CYP11B1 CYP11B2	6.04e-06	2	86	2	26047574
Pubmed	Aldosterone synthase knockout mouse as a model for sodium-induced endothelial sodium channel up-regulation in vascular endothelium.	CYP11B1 CYP11B2	6.04e-06	2	86	2	26324851
Pubmed	Cytotoxicity and decreased corticosterone production in adrenocortical Y-1 cells by 3-methylsulfonyl-DDE and structurally related molecules.	CYP11B1 CYP11B2	6.04e-06	2	86	2	18651133
Pubmed	Microsatellite polymorphism analysis allows the individual assignment of the rat 11 beta-hydroxylase gene (Cyp11b1) and the rat aldosterone synthase gene (Cyp11b2) to chromosome 7 using rat x mouse somatic cell hybrids and identifies differences between and within various rat strains.	CYP11B1 CYP11B2	6.04e-06	2	86	2	7669222
Pubmed	A new presentation of the chimeric CYP11B1/CYP11B2 gene with low prevalence of primary aldosteronism and atypical gene segregation pattern.	CYP11B1 CYP11B2	6.04e-06	2	86	2	22083159
Pubmed	Aldosterone-dependent and -independent regulation of the epithelial sodium channel (ENaC) in mouse distal nephron.	CYP11B1 CYP11B2	6.04e-06	2	86	2	22933298
Pubmed	Structural and functional analysis of the promoter region of the gene encoding mouse steroid 11 beta-hydroxylase.	CYP11B1 CYP11B2	6.04e-06	2	86	2	2783417
Pubmed	Cloning and expression of a cDNA for human cytochrome P-450aldo as related to primary aldosteronism.	CYP11B1 CYP11B2	6.04e-06	2	86	2	2256920
Pubmed	Editorial: polymorphisms in CYP11B genes and 11-hydroxylase activity.	CYP11B1 CYP11B2	6.04e-06	2	86	2	15699546
Pubmed	Cyp11b1 is induced in the murine gonad by luteinizing hormone/human chorionic gonadotropin and involved in the production of 11-ketotestosterone, a major fish androgen: conservation and evolution of the androgen metabolic pathway.	CYP11B1 CYP11B2	6.04e-06	2	86	2	18162527
Pubmed	Chronic activation of adrenal Gq signaling induces Cyp11b2 expression in the zona fasciculata and hyperaldosteronism.	CYP11B1 CYP11B2	6.04e-06	2	86	2	38341019
Pubmed	Association of DNA polymorphisms within the CYP11B2/CYP11B1 locus and postoperative hypertension risk in the patients with aldosterone-producing adenomas.	CYP11B1 CYP11B2	6.04e-06	2	86	2	20708777
Pubmed	Molecular genetic studies on the biosynthesis of aldosterone in humans.	CYP11B1 CYP11B2	6.04e-06	2	86	2	22217843
Pubmed	Mechanistic study of polychlorinated biphenyl 126-induced CYP11B1 and CYP11B2 up-regulation.	CYP11B1 CYP11B2	6.04e-06	2	86	2	16396990
Pubmed	Adrenal CYP11B1/2 expression in primary aldosteronism: immunohistochemical analysis using novel monoclonal antibodies.	CYP11B1 CYP11B2	6.04e-06	2	86	2	24837548
Pubmed	Aldosterone deficiency in mice burdens respiration and accentuates diet-induced hyperinsulinemia and obesity.	CYP11B1 CYP11B2	6.04e-06	2	86	2	30046010
Pubmed	Familial and phenotypic associations of the aldosterone Renin ratio.	CYP11B1 CYP11B2	6.04e-06	2	86	2	19820005
Pubmed	[123 I]Iodometomidate for molecular imaging of adrenocortical cytochrome P450 family 11B enzymes.	CYP11B1 CYP11B2	6.04e-06	2	86	2	18397978
Pubmed	Glucocorticoid-suppressible hyperaldosteronism results from hybrid genes created by unequal crossovers between CYP11B1 and CYP11B2.	CYP11B1 CYP11B2	6.04e-06	2	86	2	1518866
Pubmed	Aldosterone deficiency and mineralocorticoid receptor antagonism prevent angiotensin II-induced cardiac, renal, and vascular injury.	CYP11B1 CYP11B2	6.04e-06	2	86	2	22622494
Pubmed	Mutation analysis of CYP11B1 and CYP11B2 in patients with increased 18-hydroxycortisol production.	CYP11B1 CYP11B2	6.04e-06	2	86	2	15062555
Pubmed	Procollagen I-expressing renin cell precursors.	CYP11B1 CYP11B2	6.04e-06	2	86	2	23761669
Pubmed	Disturbed homeostasis in sodium-restricted mice heterozygous and homozygous for aldosterone synthase gene disruption.	CYP11B1 CYP11B2	6.04e-06	2	86	2	17075030
Pubmed	Polymorphic variation in the 11beta-hydroxylase gene associates with reduced 11-hydroxylase efficiency.	CYP11B1 CYP11B2	6.04e-06	2	86	2	17075029
Pubmed	Characterization of two genes encoding human steroid 11 beta-hydroxylase (P-450(11) beta).	CYP11B1 CYP11B2	6.04e-06	2	86	2	2592361
Pubmed	CYP11B2-CYP11B1 haplotypes associated with decreased 11 beta-hydroxylase activity.	CYP11B1 CYP11B2	6.04e-06	2	86	2	15507509
Pubmed	Polymorphism of CYP11B2 determines salt sensitivity in Japanese.	CYP11B1 CYP11B2	6.04e-06	2	86	2	17296872
Pubmed	Aldosterone deficiency prevents high-fat-feeding-induced hyperglycaemia and adipocyte dysfunction in mice.	CYP11B1 CYP11B2	6.04e-06	2	86	2	23314847
Pubmed	Effect of variation in CYP11B1 and CYP11B2 on corticosteroid phenotype and hypothalamic-pituitary-adrenal axis activity in hypertensive and normotensive subjects.	CYP11B1 CYP11B2	6.04e-06	2	86	2	17980006
Pubmed	Association between aldosterone production and variation in the 11beta-hydroxylase (CYP11B1) gene.	CYP11B1 CYP11B2	6.04e-06	2	86	2	16984984
Pubmed	Evidence for local aldosterone synthesis in the large intestine of the mouse.	CYP11B1 CYP11B2	6.04e-06	2	86	2	35288482
Pubmed	Homeostatic responses in the adrenal cortex to the absence of aldosterone in mice.	CYP11B1 CYP11B2	6.04e-06	2	86	2	15731365
Pubmed	Salt-sensitive blood pressure in mice with increased expression of aldosterone synthase.	CYP11B1 CYP11B2	6.04e-06	2	86	2	18039983
Pubmed	Cyp11b1 null mouse, a model of congenital adrenal hyperplasia.	CYP11B1 CYP11B2	6.04e-06	2	86	2	19029289
Pubmed	Genetic variation at the locus encompassing 11-beta hydroxylase and aldosterone synthase accounts for heritability in cortisol precursor (11-deoxycortisol) urinary metabolite excretion.	CYP11B1 CYP11B2	6.04e-06	2	86	2	15522937
Pubmed	Immune escape of colorectal tumours via local LRH-1/Cyp11b1-mediated synthesis of immunosuppressive glucocorticoids.	CYP11B1 CYP11B2	1.81e-05	3	86	2	36861295
Pubmed	Adrenal-Specific KO of the Circadian Clock Protein BMAL1 Alters Blood Pressure Rhythm and Timing of Eating Behavior.	CYP11B1 CYP11B2	1.81e-05	3	86	2	36778748
Pubmed	Neurosteroid biosynthesis: genes for adrenal steroidogenic enzymes are expressed in the brain.	CYP11B1 CYP11B2	1.81e-05	3	86	2	8111631
Pubmed	The roles of cAMP and cAMP-dependent protein kinase in the expression of cholesterol side chain cleavage and steroid 11 beta-hydroxylase genes in mouse adrenocortical tumor cells.	CYP11B1 CYP11B2	1.81e-05	3	86	2	2546938
Pubmed	Kidney function in mice lacking aldosterone.	CYP11B1 CYP11B2	1.81e-05	3	86	2	16118390
Pubmed	Interaction of CYP11B1 (cytochrome P-45011 beta) with CYP11A1 (cytochrome P-450scc) in COS-1 cells.	CYP11B1 CYP11B2	1.81e-05	3	86	2	10411633
Pubmed	Differential effects of high and low steroidogenic factor-1 expression on CYP11B2 expression and aldosterone production in adrenocortical cells.	CYP11B1 CYP11B2	1.81e-05	3	86	2	18974272
Pubmed	Evidence of interaction between genes in the folate/homocysteine metabolic pathway in controlling risk of non-syndromic oral cleft.	DMGDH BHMT	1.81e-05	3	86	2	29356306
Pubmed	Aldosterone-induced coronary dysfunction in transgenic mice involves the calcium-activated potassium (BKCa) channels of vascular smooth muscle cells.	CYP11B1 CYP11B2	1.81e-05	3	86	2	17984374
Pubmed	Different isozymes of mouse 11 beta-hydroxylase produce mineralocorticoids and glucocorticoids.	CYP11B1 CYP11B2	1.81e-05	3	86	2	1686470
Pubmed	Identification and characterization of two upstream elements that regulate adrenocortical expression of steroid 11 beta-hydroxylase.	CYP11B1 CYP11B2	1.81e-05	3	86	2	2233742
Pubmed	Substrate-induced modulation of protein-protein interactions within human mitochondrial cytochrome P450-dependent system.	CYP11B1 CYP11B2	1.81e-05	3	86	2	33271253
Pubmed	Mislocalization of protein kinase A drives pathology in Cushing's syndrome.	CYP11B1 CYP11B2	1.81e-05	3	86	2	35830806
Pubmed	Diversity of human copy number variation and multicopy genes.	TBC1D3E TBC1D3G	1.81e-05	3	86	2	21030649
Pubmed	The prolactin regulatory element-binding regulates of the 11beta-hydroxylase gene.	CYP11B1 CYP11B2	1.81e-05	3	86	2	18801336
Pubmed	Differential regulation of aldosterone synthase and 11beta-hydroxylase transcription by steroidogenic factor-1.	CYP11B1 CYP11B2	1.81e-05	3	86	2	11932209
Pubmed	Testis-enriched ferlin, FER1L5, is required for Ca2+-activated acrosome reaction and male fertility.	FER1L4 FER1L6	1.81e-05	3	86	2	36696506
Pubmed	Aldosterone postnatally, but not at birth, is required for optimal induction of renal mineralocorticoid receptor expression and sodium reabsorption.	CYP11B1 CYP11B2	1.81e-05	3	86	2	21467193
Pubmed	Control of renin secretion from kidneys with renin cell hyperplasia.	CYP11B1 CYP11B2	1.81e-05	3	86	2	24285498
Pubmed	Expression of the steroidogenic enzyme P450scc in the central and peripheral nervous systems during rodent embryogenesis.	CYP11B1 CYP11B2	1.81e-05	3	86	2	7750493
Pubmed	Antiaging Gene Klotho Regulates Adrenal CYP11B2 Expression and Aldosterone Synthesis.	CYP11B1 CYP11B2	1.81e-05	3	86	2	26471128
Pubmed	Molecular Recognition in Mitochondrial Cytochromes P450 That Catalyze the Terminal Steps of Corticosteroid Biosynthesis.	CYP11B1 CYP11B2	1.81e-05	3	86	2	28355486
Pubmed	Angiotensin II induces coordinated calcium bursts in aldosterone-producing adrenal rosettes.	CYP11B1 CYP11B2	1.81e-05	3	86	2	32245948
Pubmed	Zona Glomerulosa-Derived Klotho Modulates Aldosterone Synthase Expression in Young Female Mice.	CYP11B1 CYP11B2	3.61e-05	4	86	2	38573585
Pubmed	Adrenal Abcg1 Controls Cholesterol Flux and Steroidogenesis.	CYP11B1 CYP11B2	3.61e-05	4	86	2	38301271
Pubmed	Crosstalk between androgen receptor and WNT/β-catenin signaling causes sex-specific adrenocortical hyperplasia in mice.	CYP11B1 CYP11B2	3.61e-05	4	86	2	37102205
Pubmed	Familial varieties of primary aldosteronism.	CYP11B1 CYP11B2	3.61e-05	4	86	2	11903322
Pubmed	Regulation of aldosterone and cortisol production by the transcriptional repressor neuron restrictive silencer factor.	CYP11B1 CYP11B2	3.61e-05	4	86	2	19342457
Pubmed	Cutting Edge: De Novo Glucocorticoid Synthesis by Thymic Epithelial Cells Regulates Antigen-Specific Thymocyte Selection.	CYP11B1 CYP11B2	3.61e-05	4	86	2	29440508
Pubmed	The aldo-keto reductase AKR1B7 coexpresses with renin without influencing renin production and secretion.	CYP11B1 CYP11B2	3.61e-05	4	86	2	23303406
Pubmed	Single-Cell Resolution and Quantitation of Targeted Glucocorticoid Delivery in the Thymus.	CYP11B1 CYP11B2	3.61e-05	4	86	2	30917317
Pubmed	Beta-Catenin Causes Adrenal Hyperplasia by Blocking Zonal Transdifferentiation.	CYP11B1 CYP11B2	3.61e-05	4	86	2	32320669
Pubmed	β-Catenin-Driven Differentiation Is a Tissue-Specific Epigenetic Vulnerability in Adrenal Cancer.	CYP11B1 CYP11B2	3.61e-05	4	86	2	37129912
Pubmed	Twin genes and endocrine disease: CYP21 and CYP11B genes.	CYP11B1 CYP11B2	3.61e-05	4	86	2	8372604
Pubmed	Wnt/β-catenin activation cooperates with loss of p53 to cause adrenocortical carcinoma in mice.	CYP11B1 CYP11B2	3.61e-05	4	86	2	32561853
Pubmed	β-Catenin and FGFR2 regulate postnatal rosette-based adrenocortical morphogenesis.	CYP11B1 CYP11B2	3.61e-05	4	86	2	32245949
Interaction	CLIC3 interactions	SEPHS2 TBC1D3 PROSER2 TBC1D3C TBC1D3K	6.48e-06	63	84	5	int:CLIC3
Cytoband	Ensembl 112 genes in cytogenetic band chr17q12	TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3I TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F	5.74e-15	149	86	11	chr17q12
Cytoband	17q12	TBC1D3 TBC1D3H TBC1D3C TBC1D3B TBC1D3F	1.28e-06	99	86	5	17q12
Cytoband	Ensembl 112 genes in cytogenetic band chr8q24	NRBP2 ADCK5 CYP11B1 CYP11B2 BOP1 EXT1 FER1L6	4.96e-06	355	86	7	chr8q24
Cytoband	8q24.3	NRBP2 ADCK5 BOP1	1.28e-03	113	86	3	8q24.3
Cytoband	8p21.3	PHYHIP PEBP4	2.33e-03	38	86	2	8p21.3
Cytoband	22q13.33	IL17REL BRD1	2.33e-03	38	86	2	22q13.33
Cytoband	5q14.1	DMGDH BHMT	2.46e-03	39	86	2	5q14.1
Cytoband	Ensembl 112 genes in cytogenetic band chrXq26	RTL8B RTL8A RTL8C	4.14e-03	171	86	3	chrXq26
GeneFamily	Cytochrome P450 family 11	CYP11B1 CYP11B2	1.81e-05	3	45	2	1007
GeneFamily	Ferlin family	FER1L4 FER1L6	9.03e-05	6	45	2	828
GeneFamily	MAGE family	TRO MAGEB18 MAGEB17	1.33e-04	40	45	3	1136
GeneFamily	Autophagy related	ATG4B ATG2B	3.05e-03	33	45	2	1022
Coexpression	NIKOLSKY_BREAST_CANCER_8Q23_Q24_AMPLICON	NRBP2 ADCK5 CYP11B1 CYP11B2 BOP1 EXT1 FER1L6	7.44e-07	157	84	7	M17936
CoexpressionAtlas	Mesoderm Day 15_vs_Mesoderm Day 30-Confounder_removed-fold2.0_adjp0.05	TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F	1.03e-10	90	86	9	PCBC_ratio_MESO-15_vs_MESO-30_cfr-2X-p05
CoexpressionAtlas	DE cord blood_vs_DE blastocyst-Confounder_removed-fold2.0_adjp0.05	JCAD TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3G TBC1D3C TBC1D3B CNGA4 TBC1D3K TBC1D3F	3.87e-09	242	86	11	PCBC_ratio_DE cord blood_vs_DE blastocyst_cfr-2X-p05
CoexpressionAtlas	Endoderm Differentiated Cells-reprogram_OSKM-L_vs_Endoderm Differentiated Cells-reprogram_NA-Confounder_removed-fold2.0_adjp0.05	TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3G TBC1D3C TBC1D3B CNGA4 TBC1D3K TBC1D3F	1.52e-08	213	86	10	PCBC_ratio_DE_from-OSKM-L_vs_DE_from-ESC_cfr-2X-p05
CoexpressionAtlas	Endoderm Differentiated Cells-method_mRNA_vs_Endoderm Differentiated Cells-method_NA-Confounder_removed-fold2.0_adjp0.05	TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3G TBC1D3C TBC1D3B CNGA4 TBC1D3K TBC1D3F	1.52e-08	213	86	10	PCBC_ratio_DE_from-mRNA_vs_DE_from-ESC_cfr-2X-p05
CoexpressionAtlas	Mesoderm Day 5-reprogram_OSKM-L_vs_Mesoderm Day 5-reprogram_NA-Confounder_removed-fold2.0_adjp0.05	TBC1D3 TBC1D3H TBC1D3L TBC1D3D PAPLN TBC1D3G TBC1D3C TBC1D3B CNGA4 TBC1D3K TBC1D3F	1.82e-08	281	86	11	PCBC_ratio_MESO-5_from-OSKM-L_vs_MESO-5_from-ESC_cfr-2X-p05
CoexpressionAtlas	Mesoderm Day 5-method_mRNA_vs_Mesoderm Day 5-method_NA-Confounder_removed-fold2.0_adjp0.05	TBC1D3 TBC1D3H TBC1D3L TBC1D3D PAPLN TBC1D3G TBC1D3C TBC1D3B CNGA4 TBC1D3K TBC1D3F	1.82e-08	281	86	11	PCBC_ratio_MESO-5_from-mRNA_vs_MESO-5_from-ESC_cfr-2X-p05
CoexpressionAtlas	Mesoderm Day 5_vs_Endoderm Differentiated Cells-Confounder_removed-fold2.0_adjp0.05	JCAD TBC1D3 TBC1D3H TBC1D3L TBC1D3D EXT1 TBC1D3G TBC1D3C TBC1D3B TBC1D3K TBC1D3F	6.87e-08	320	86	11	PCBC_ratio_MESO-5_vs_DE_cfr-2X-p05
CoexpressionAtlas	Mesoderm Day 5_vs_Pluripotent Stem Cells-Confounder_removed-fold2.0_adjp0.05	JCAD NRBP2 ARL6IP6 TBC1D3 TBC1D3H TBC1D3L TBC1D3D ADCK5 TRO BAD EXT1 PROSER2 TBC1D3G TBC1D3C ABCA7 TBC1D3B HERPUD1 TBC1D3K TBC1D3F	1.34e-07	1153	86	19	PCBC_ratio_MESO-5_vs_SC_cfr-2X-p05
CoexpressionAtlas	ratio_induced-Ectoderm_vs_StemCell_top-relative-expression-ranked_1000	DMGDH JCAD ENDOD1 NRBP2 TBC1D3 TBC1D3H ZNF862 FER1L4 SLC4A10 NTN5 IFITM10 SSPOP TBC1D3C TBC1D3B PRRT4 TBC1D3F	1.88e-06	986	86	16	PCBC_ratio_ECTO_vs_SC_1000
CoexpressionAtlas	Mesoderm Day 15_vs_Mesoderm Day 5-Confounder_removed-fold2.0_adjp0.05	MEP1A TGFBR3 NRBP2 TBC1D3 TBC1D3H TBC1D3L TBC1D3D C6orf89 TBC1D3G TBC1D3C TBC1D3B HERPUD1 TBC1D3K BHMT TBC1D3F	1.86e-05	1049	86	15	PCBC_ratio_MESO-15_vs_MESO-5_cfr-2X-p05
CoexpressionAtlas	Ectoderm Differentiated Cells_vs_Endoderm Differentiated Cells-Confounder_removed-fold2.0_adjp0.05	TGFBR3 ENDOD1 NRBP2 TBC1D3 TBC1D3H TBC1D3L TBC1D3D RTL8B SMO TBC1D3G TBC1D3C ABCA7 TBC1D3B TBC1D3K TBC1D3F	2.48e-05	1075	86	15	PCBC_ratio_ECTO_vs_DE_cfr-2X-p05
CoexpressionAtlas	Ectoderm Differentiated Cells_vs_Pluripotent Stem Cells-Confounder_removed-fold2.0_adjp0.05	TGFBR3 ENDOD1 NRBP2 TBC1D3 TBC1D3H TBC1D3L TBC1D3D C6orf89 RTL8B TRO BAD TBC1D3G TBC1D3C ABCA7 TBC1D3B TBC1D3K TBC1D3F	6.97e-05	1466	86	17	PCBC_ratio_ECTO_vs_SC_cfr-2X-p05
Disease	adrenal cortical adenoma (is_marker_for)	CYP11B1 CYP11B2	6.04e-06	2	73	2	DOID:0050891 (is_marker_for)
Disease	Glucocorticoid-remediable aldosteronism	CYP11B1 CYP11B2	6.04e-06	2	73	2	C1260386
Disease	congenital adrenal hyperplasia (implicated_via_orthology)	CYP11B1 CYP11B2	1.81e-05	3	73	2	DOID:0050811 (implicated_via_orthology)
Disease	primary hyperaldosteronism (is_implicated_in)	CYP11B1 CYP11B2	6.01e-05	5	73	2	DOID:446 (is_implicated_in)
Disease	Conn Syndrome	CYP11B1 CYP11B2	9.00e-05	6	73	2	C1384514
Disease	Hyperaldosteronism	CYP11B1 CYP11B2	9.00e-05	6	73	2	C0020428
Disease	protocadherin alpha-7 measurement	CYP11B1 CYP11B2	1.26e-04	7	73	2	EFO_0801973
Disease	limb-girdle muscular dystrophy (implicated_via_orthology)	FER1L4 FER1L6	1.26e-04	7	73	2	DOID:11724 (implicated_via_orthology)
Disease	Alzheimer disease	MPO ABCA7	1.67e-04	8	73	2	cv:C0002395
Disease	pancreatic cancer (is_implicated_in)	MPO BAD SMO HSPB1	1.75e-04	112	73	4	DOID:1793 (is_implicated_in)
Disease	Calcium channel blocker use measurement	TRIM46 USP38 CYP11B2 CYP27B1 SLC4A10	1.89e-04	213	73	5	EFO_0009930
Disease	primary bacterial infectious disease (implicated_via_orthology)	DUOX2 SMO	2.15e-04	9	73	2	DOID:0050338 (implicated_via_orthology)
Disease	lactosyl-N-nervonoyl-sphingosine (d18:1/24:1) measurement	ABCA7 HERPUD1	2.15e-04	9	73	2	EFO_0800517
Disease	protein FAM163B measurement	CYP11B1 CYP11B2	2.15e-04	9	73	2	EFO_0802936
Disease	androstenedione measurement	CYP11B1 CYP11B2	2.68e-04	10	73	2	EFO_0007972
Disease	3-hydroxyanthranilate 3,4-dioxygenase measurement	CYP11B1 CYP11B2	3.27e-04	11	73	2	EFO_0021862
Disease	cell growth regulator with EF hand domain protein 1 measurement	CYP11B1 CYP11B2	3.27e-04	11	73	2	EFO_0801461
Disease	granulysin measurement	CYP11B1 FBXW5	6.21e-04	15	73	2	EFO_0008144
Disease	CCL4 measurement	TBC1D3 TBC1D3F	1.11e-03	20	73	2	EFO_0004751
Disease	visual epilepsy (biomarker_via_orthology)	BAD SMO BRD1	1.46e-03	90	73	3	DOID:11832 (biomarker_via_orthology)
Disease	peak expiratory flow	DMGDH JCAD TGFBR3 CYP27B1 ZC3H12D BRD1	1.47e-03	498	73	6	EFO_0009718
Disease	apolipoprotein L1 measurement	CYP11B1 CYP11B2	1.75e-03	25	73	2	EFO_0021854
Disease	pre-eclampsia (is_implicated_in)	CYP11B2 CD46	1.75e-03	25	73	2	DOID:10591 (is_implicated_in)
Disease	acute kidney failure (implicated_via_orthology)	MPO CYP27B1	2.04e-03	27	73	2	DOID:3021 (implicated_via_orthology)
Disease	pulse pressure measurement	JCAD TGFBR3 MXRA5 ARL6IP6 CYP11B2 FBRSL1 CD46 BRD1 SSPOP CCDC157	2.19e-03	1392	73	10	EFO_0005763
Disease	selenium measurement	DMGDH BHMT	2.35e-03	29	73	2	EFO_0006331

Protein segments in the cluster

Peptide	Gene	Start	Entry
GWIQPRRPRDPTPSF	BOP1	266	Q14137
EFPFGLEPRVATRWD	BHMT	266	Q93088
PGFAWEPFRGLELPR	FBRSL1	891	Q9HCM7
RPAAAPRRPFSWEDV	BRD1	686	O95696
SPFRGRSRSAPPNLW	BAD	91	Q92934
PRLWSFRSGQPARVP	AJAP1	61	Q9UKB5
RAPSVPPFLRWAGYR	BCL2L12	31	Q9HB09
PWPSPAVFFRRNVRG	ADCK5	21	Q3MIX3
RAGPVRFPSWKFPDR	CCDC157	31	Q569K6
FPIPDLRSDQERGPW	ATG2B	756	Q96BY7
FPAGAEVTNRPSPWR	ATG4B	206	Q9Y4P1
NFPFRRSYWCGPRPP	ABCA7	766	Q8IZY2
EDFRRPLQGEWRRPP	RBM12B	681	Q8IXT5
PLQGEWRRPPEDDFR	RBM12B	686	Q8IXT5
GWFPFRPRPVQNFPN	HERPUD1	306	Q15011
FPVAPEELRAPGSRW	ARHGEF19	51	Q8IW93
QFPEPNSFRPARWLG	CYP27B1	421	O15528
PRRPPLQWRYSEVSF	NRBP2	351	Q9NSY0
WQRGRIPFFVKPPNA	GNL2	451	Q13823
PPRYEFLWGPRARAE	MAGEB17	266	A8MXT2
NSDPPRYEFLWGPRA	MAGEB18	261	Q96M61
RRECPFPSWRFPGLL	CD46	6	P15529
WVRCPFEQRRFPTPP	IL17REL	281	Q6ZVW7
RAWPPSPGRFRVEEG	JCAD	926	Q9P266
QRPELQFFPLRKGPW	FER1L4	866	A9Z1Z3
FPRNTERPPETGPWR	LMTK3	1011	Q96Q04
PFQRSRWDPETGRSP	DUOX2	151	Q9NRD8
FRAPRPAPGGAEQRW	ENDOD1	81	O94919
VLQAPRPRPRTFFSW	FBXW5	546	Q969U6
RERSPSPSFRWPFSG	PCYT1A	326	P49585
PNPRVPLSRVFFASW	MPO	521	P05164
DPDAPSRAEPRQRFW	PEBP4	96	Q96S96
VPFSLLRGPSWDPFR	HSPB1	6	P04792
DPARPDGSWTFAQRP	ABT1	201	Q9ULW3
WSPGQPSFLQPRELR	CASC3	476	O15234
PRFPDALRPFVPWDQ	EXT1	56	Q16394
FRPLPQPREAWGLSD	CPLANE1	2251	Q9H799
EPGVWVARPPRFRAQ	C14orf93	436	Q9H972
EARVPLDGAFWIPRP	IFITM10	51	A6NMD0
LFPRPERYNPQRWLD	CYP11B1	416	P15538
RPGREAAQWFPPQDR	HASPIN	26	Q8TF76
RPSFRRTNWFEPVGS	DMGDH	506	Q9UI17
LFPRPERYNPQRWLD	CYP11B2	416	P19099
FPFPYPWRRPLNRSQ	C6orf89	226	Q6UWU4
EGGPRPWILEPSRFF	NUP210L	676	Q5VU65
PWGRVGFPSISPFRF	GPRASP1	1056	Q5JY77
LIPNGFPLERPWARF	FER1L6	231	Q2WGJ9
RRWRNPIPFPETFDG	RTL8A	21	Q9BWD3
RRWRNPIPFPETFDG	RTL8B	21	Q17RB0
RRWRNPIPFPETFDG	RTL8C	21	A6ZKI3
FRRTDVPAQPGPTRW	TRIM46	466	Q7Z4K8
VRARFRSPSNPPAAW	SSPOP	2736	A2VEC9
PGFWRDPSQPIFSRR	NTN5	256	Q8WTR8
PFREGRPGEWRTPAA	PROSER2	216	Q86WR7
NGLRDPNTRWTFPIP	MEP1A	66	Q16819
WHVRREPGGRPFYLP	ARHGAP27	46	Q6ZUM4
PQDSPYGRWRFQIPA	PHYHIP	196	Q92561
PRLPTDLDVEGPWFR	TBC1D3L	456	B9A6J9
RLGPRAGFRFWPPFF	PPP1R15B	11	Q5SWA1
AGFRFWPPFFPRRSQ	PPP1R15B	16	Q5SWA1
FPAAAGSRAQPRRWP	ARL6IP6	91	Q8N6S5
WVYPDPAQPGFERLR	CNGA4	201	Q8IV77
PRLPTDLDVEGPWFR	TBC1D3B	456	A6NDS4
PRLPTDLDVEGPWFR	TBC1D3H	456	P0C7X1
SGQRPRRWCPPPFFY	YBX2	216	Q9Y2T7
RPFEPQALGLSPSWR	SEPHS2	36	Q99611
PNSRPPEYEFFWGLR	TRO	596	Q12816
PRLPTDLDVEGPWFR	TBC1D3F	456	A6NER0
RAEGFPPPAIEWQRD	PAPLN	1066	O95428
PDTWERFVRRFGPLQ	SLC27A3	406	Q5K4L6
RDDRGWFVTPLGPNP	SLC4A10	796	Q6U841
LPQGRSPFAPRESWR	PRRT4	541	C9JH25
PRLPTDLDVEGPWFR	TBC1D3E	456	A0A087X179
RGWPDFLRCTPDRFP	SMO	161	Q99835
RIFFEASRPPWFTPR	USP38	506	Q8NB14
PRSDRFPGRSVWAEP	ZC3H12D	441	A2A288
NPELFRKFGRGPEPW	ZNF862	51	O60290
PIWAARFRSIRDPPG	ZNF862	211	O60290
KEPFRPGSFRPNWQL	TRIM10	61	Q9UDY6
PRLPTDLDVEGPWFR	TBC1D3D	456	A0A087WVF3
PRLPTDLDVEGPWFR	TBC1D3G	456	Q6DHY5
PRLPTDLDVEGPWFR	TBC1D3	456	Q8IZP1
PRLPTDLDVEGPWFR	TBC1D3K	456	A0A087X1G2
PRLPTDLDVEGPWFR	TBC1D3I	456	A0A087WXS9
PRLPTDLDVEGPWFR	TBC1D3C	456	Q6IPX1
LPFPFPDISRRVWNE	TGFBR3	401	Q03167
ELRRFELPFDWPRCP	KMT2D	81	O14686
ELRPYFRDRGWPLPG	LMF1	551	Q96S06
GTPAPQISWIFPDRR	MXRA5	1976	Q9NR99