Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionATP-dependent diacylglycerol kinase activity

DGKZ DGKE DGKD DGKK DGKI

2.08e-09111105GO:0004143
GeneOntologyMolecularFunctioncomplement binding

ITGAM C4A C4B C8A MASP2

8.28e-07321105GO:0001848
GeneOntologyMolecularFunctionlipid kinase activity

DGKZ DGKE DGKD DGKK DGKI

2.96e-06411105GO:0001727
GeneOntologyMolecularFunctionD-glucose:sodium symporter activity

SLC5A10 SLC5A9 SLC5A1

5.60e-0671103GO:0005412
GeneOntologyMolecularFunctionopsonin binding

ITGAM C4A C4B MASP2

1.01e-05251104GO:0001846
GeneOntologyMolecularFunctioncarbohydrate:monoatomic cation symporter activity

SLC5A10 SLC5A9 SLC5A1

1.05e-04171103GO:0005402
GeneOntologyMolecularFunctionhexose transmembrane transporter activity

SLC5A10 SLC5A9 SLC5A1

3.42e-04251103GO:0015149
GeneOntologyMolecularFunctionD-glucose transmembrane transporter activity

SLC5A10 SLC5A9 SLC5A1

3.42e-04251103GO:0055056
GeneOntologyMolecularFunctionmonosaccharide transmembrane transporter activity

SLC5A10 SLC5A9 SLC5A1

4.32e-04271103GO:0015145
GeneOntologyMolecularFunctionsugar transmembrane transporter activity

SLC5A10 SLC5A9 SLC5A1

5.35e-04291103GO:0051119
GeneOntologyMolecularFunctioncomplement component C1q complex binding

C4A C4B

1.31e-03101102GO:0001849
GeneOntologyBiologicalProcesslipid phosphorylation

DGKZ DGKE DGKD DGKK DGKI

1.69e-09111095GO:0046834
GeneOntologyBiologicalProcessdiacylglycerol metabolic process

DGKZ DGKE DGKD DGKK DGKI

3.35e-07281095GO:0046339
GeneOntologyBiologicalProcessphosphatidic acid biosynthetic process

DGKZ DGKE DGKD DGKK DGKI

1.24e-06361095GO:0006654
GeneOntologyBiologicalProcessphosphatidic acid metabolic process

DGKZ DGKE DGKD DGKK DGKI

2.42e-06411095GO:0046473
GeneOntologyBiologicalProcesshumoral immune response mediated by circulating immunoglobulin

NOD2 C4A C4B C8A MASP2

1.91e-05621095GO:0002455
GeneOntologyBiologicalProcesscomplement activation

FCN3 C4A C4B C8A MASP2

3.46e-05701095GO:0006956
GeneOntologyBiologicalProcesscomplement activation, classical pathway

C4A C4B C8A MASP2

8.51e-05441094GO:0006958
HumanPhenoReduced circulating complement concentration

ITGAM C4A C4B C8A MASP2

3.47e-0558345HP:0004431
HumanPhenoAbnormality of complement system

ITGAM C4A C4B C8A MASP2

4.44e-0561345HP:0005339
DomainDAGK_acc

DGKZ DGKE DGKD DGKK DGKI

1.45e-09101085PF00609
DomainDiacylglycerol_kin_accessory

DGKZ DGKE DGKD DGKK DGKI

1.45e-09101085IPR000756
DomainDAGKa

DGKZ DGKE DGKD DGKK DGKI

1.45e-09101085SM00045
DomainDAGKc

DGKZ DGKE DGKD DGKK DGKI

1.13e-08141085SM00046
DomainDiacylglycerol_kinase_cat_dom

DGKZ DGKE DGKD DGKK DGKI

1.69e-08151085IPR001206
DomainDAGK

DGKZ DGKE DGKD DGKK DGKI

1.69e-08151085PS50146
DomainDAGK_cat

DGKZ DGKE DGKD DGKK DGKI

1.69e-08151085PF00781
DomainNAD/diacylglycerol_kinase

DGKZ DGKE DGKD DGKK DGKI

3.45e-08171085IPR016064
Domain-

RCCD1 RCC1L UBR5 HERC3 HERC4

1.43e-072210852.130.10.30
DomainRCC1/BLIP-II

RCCD1 RCC1L UBR5 HERC3 HERC4

1.82e-07231085IPR009091
DomainRCC1

RCCD1 RCC1L HERC3 HERC4

4.77e-06201084PF00415
DomainRCC1_1

RCCD1 RCC1L HERC3 HERC4

5.87e-06211084PS00625
DomainRCC1_2

RCCD1 RCC1L HERC3 HERC4

5.87e-06211084PS00626
DomainRCC1_3

RCCD1 RCC1L HERC3 HERC4

5.87e-06211084PS50012
DomainReg_chr_condens

RCCD1 RCC1L HERC3 HERC4

7.14e-06221084IPR000408
DomainNa/solute_symporter_CS

SLC5A10 SLC5A9 SLC5A1

1.03e-0581083IPR018212
DomainHECT

UBR5 HERC3 HECTD1 HERC4

1.67e-05271084PF00632
DomainHECTc

UBR5 HERC3 HECTD1 HERC4

1.67e-05271084SM00119
DomainHECT_dom

UBR5 HERC3 HECTD1 HERC4

1.67e-05271084IPR000569
DomainHECT

UBR5 HERC3 HECTD1 HERC4

1.67e-05271084PS50237
DomainC1_1

DGKZ DGKE DGKD DGKK DGKI

1.94e-05571085PF00130
DomainZF_DAG_PE_1

DGKZ DGKE DGKD DGKK DGKI

3.42e-05641085PS00479
DomainZF_DAG_PE_2

DGKZ DGKE DGKD DGKK DGKI

3.42e-05641085PS50081
DomainC1

DGKZ DGKE DGKD DGKK DGKI

3.69e-05651085SM00109
DomainPE/DAG-bd

DGKZ DGKE DGKD DGKK DGKI

3.98e-05661085IPR002219
DomainSSF

SLC5A10 SLC5A9 SLC5A1

3.98e-05121083PF00474
DomainNA_SOLUT_SYMP_2

SLC5A10 SLC5A9 SLC5A1

3.98e-05121083PS00457
DomainNa/solute_symporter

SLC5A10 SLC5A9 SLC5A1

3.98e-05121083IPR001734
DomainNA_SOLUT_SYMP_3

SLC5A10 SLC5A9 SLC5A1

3.98e-05121083PS50283
DomainAgo_hook

TNRC6B TNRC6A

9.90e-0531082PF10427
DomainTNRC6_PABC-bd

TNRC6B TNRC6A

9.90e-0531082IPR032226
DomainArgonaute_hook_dom

TNRC6B TNRC6A

9.90e-0531082IPR019486
DomainTNRC6-PABC_bdg

TNRC6B TNRC6A

9.90e-0531082PF16608
DomainMAM

MALRD1 PTPRK ALK

1.44e-04181083PF00629
DomainMAM_dom

MALRD1 PTPRK ALK

1.44e-04181083IPR000998
DomainMAM_2

MALRD1 PTPRK ALK

1.44e-04181083PS50060
DomainAnaphylatoxin_comp_syst

C4A C4B

3.28e-0451082IPR018081
DomainAnaphylatoxn_comp_syst_dom

C4A C4B

3.28e-0451082IPR001840
DomainANATO

C4A C4B

6.83e-0471082SM00104
DomainANAPHYLATOXIN_2

C4A C4B

6.83e-0471082PS01178
DomainANAPHYLATOXIN_1

C4A C4B

6.83e-0471082PS01177
DomainANATO

C4A C4B

6.83e-0471082PF01821
DomainAnaphylatoxin/fibulin

C4A C4B

6.83e-0471082IPR000020
DomainMacrogloblnA2_thiol-ester-bond

C4A C4B

9.07e-0481082IPR019565
DomainThiol-ester_cl

C4A C4B

9.07e-0481082PF10569
DomainMacrogloblnA2_CS

C4A C4B

9.07e-0481082IPR019742
DomainA2M

C4A C4B

1.45e-03101082PF00207
DomainA2M_N_2

C4A C4B

1.45e-03101082IPR011625
DomainA2M_comp

C4A C4B

1.45e-03101082IPR011626
DomainA2M_recep

C4A C4B

1.45e-03101082PF07677
DomainA2M_comp

C4A C4B

1.45e-03101082PF07678
DomainA2M_N

C4A C4B

1.45e-03101082PF01835
DomainA2M_N

C4A C4B

1.45e-03101082IPR002890
DomainA-macroglobulin_rcpt-bd

C4A C4B

1.45e-03101082IPR009048
DomainALPHA_2_MACROGLOBULIN

C4A C4B

1.45e-03101082PS00477
DomainA2M_N_2

C4A C4B

1.45e-03101082PF07703
DomainMacroglobln_a2

C4A C4B

1.45e-03101082IPR001599
DomainNA_SOLUT_SYMP_1

SLC5A9 SLC5A1

1.76e-03111082PS00456
Domain-

MALRD1 C8A ALK

2.38e-034610834.10.400.10
DomainLDLRA_1

MALRD1 C8A ALK

2.69e-03481083PS01209
DomainLDrepeatLR_classA_rpt

MALRD1 C8A ALK

2.86e-03491083IPR002172
DomainLDLa

MALRD1 C8A ALK

2.86e-03491083SM00192
DomainLDLRA_2

MALRD1 C8A ALK

2.86e-03491083PS50068
DomainPP2C_SIG

PPM1L PPM1N

2.88e-03141082SM00331
DomainPPM_1

PPM1L PPM1N

3.31e-03151082PS01032
DomainMAM_1

PTPRK ALK

3.77e-03161082PS00740
DomainPP2C

PPM1L PPM1N

4.26e-03171082IPR015655
DomainMAM

MALRD1 PTPRK

4.26e-03171082SM00137
DomainPropept_inh

PCSK1 CPA5

4.26e-03171082IPR009020
DomainC345C

C4A C4B

4.26e-03171082SM00643
DomainCUB_dom

MGAT3 DMBT1 MASP2

4.39e-03571083IPR000859
DomainTerpenoid_cyclase/PrenylTrfase

C4A C4B

4.77e-03181082IPR008930
DomainZn_pept

CPA5 CPZ

4.77e-03181082SM00631
DomainPP2C

PPM1L PPM1N

5.31e-03191082PF00481
DomainNTR

C4A C4B

5.31e-03191082PF01759
DomainFibrinogen_CS

FCN3 TNN

5.31e-03191082IPR020837
DomainNetrin_module_non-TIMP

C4A C4B

5.31e-03191082IPR018933
DomainCARBOXYPEPT_ZN_2

CPA5 CPZ

5.31e-03191082PS00133
PathwayREACTOME_EFFECTS_OF_PIP2_HYDROLYSIS

DGKZ DGKE DGKD DGKK DGKI

2.68e-0725815MM14511
PathwayKEGG_MEDICUS_REFERENCE_LECTIN_PATHWAY_OF_COMPLEMENT_CASCADE_C4_C2_TO_C3_CONVERTASE_FORMATION

FCN3 C4A C4B MASP2

3.24e-0711814M47874
PathwayREACTOME_EFFECTS_OF_PIP2_HYDROLYSIS

DGKZ DGKE DGKD DGKK DGKI

4.04e-0727815M12123
PathwayBIOCARTA_LECTIN_PATHWAY

C4A C4B C8A MASP2

6.95e-0713814M4732
PathwayBIOCARTA_COMP_PATHWAY

C4A C4B C8A MASP2

4.57e-0620814M917
PathwayWP_COMPLEMENT_ACTIVATION

C4A C4B C8A MASP2

6.84e-0622814M39502
PathwayBIOCARTA_LECTIN_PATHWAY

C4A C4B MASP2

2.92e-0511813MM1430
PathwayWP_COMPLEMENT_SYSTEM_IN_NEURONAL_DEVELOPMENT_AND_PLASTICITY

FCN3 ITGAM C4A C4B C8A MASP2

3.22e-05106816M42535
PathwayBIOCARTA_CLASSIC_PATHWAY

C4A C4B C8A

7.91e-0515813M7146
PathwayWP_COMPLEMENT_ACTIVATION_CLASSICAL_PATHWAY

C4A C4B C8A

1.17e-0417813MM15944
PathwayBIOCARTA_COMP_PATHWAY

C4A C4B MASP2

1.17e-0417813MM1369
PathwayREACTOME_CELLULAR_HEXOSE_TRANSPORT

SLC5A10 SLC5A9 SLC5A1

1.66e-0419813MM14718
PathwayKEGG_GLYCEROLIPID_METABOLISM

DGKZ DGKE DGKD DGKI

1.76e-0449814M15902
PathwayREACTOME_CELLULAR_HEXOSE_TRANSPORT

SLC5A10 SLC5A9 SLC5A1

2.26e-0421813M27058
PathwayWP_GLP1_SECRETION_FROM_INTESTINE_TO_PORTAL_VEIN

PCSK1 SLC5A1

3.22e-045812M48329
PathwayREACTOME_FICOLINS_BIND_TO_REPETITIVE_CARBOHYDRATE_STRUCTURES_ON_THE_TARGET_CELL_SURFACE

FCN3 MASP2

3.22e-045812M27204
PathwayREACTOME_POST_TRANSCRIPTIONAL_SILENCING_BY_SMALL_RNAS

TNRC6B TNRC6A

4.82e-046812MM15083
PathwayREACTOME_COMPLEMENT_CASCADE

FCN3 C4A C4B C8A MASP2

5.18e-04115815M19752
PathwayKEGG_COMPLEMENT_AND_COAGULATION_CASCADES

C4A C4B C8A MASP2

6.59e-0469814M16894
PathwayREACTOME_ACTIVATION_OF_C3_AND_C5

C4A C4B

6.72e-047812MM14685
PathwayREACTOME_POST_TRANSCRIPTIONAL_SILENCING_BY_SMALL_RNAS

TNRC6B TNRC6A

6.72e-047812M46421
PathwayREACTOME_ACTIVATION_OF_C3_AND_C5

C4A C4B

8.93e-048812M27031
PathwayREACTOME_LECTIN_PATHWAY_OF_COMPLEMENT_ACTIVATION

FCN3 MASP2

8.93e-048812M27005
PathwayKEGG_MEDICUS_REFERENCE_CLASSICAL_PATHWAY_OF_COMPLEMENT_CASCADE_C4_C2_TO_C3_CONVERTASE_FORMATION

C4A C4B

8.93e-048812M47872
PathwayKEGG_MEDICUS_REFERENCE_LECTIN_PATHWAY_OF_COAGULATION_CASCADE_PROTHROMBIN_TO_THROMBIN

FCN3 MASP2

8.93e-048812M47784
PathwayKEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM

DGKZ DGKE DGKD DGKI

9.48e-0476814M9052
PathwayKEGG_GLYCEROPHOSPHOLIPID_METABOLISM

DGKZ DGKE DGKD DGKI

9.96e-0477814M9131
PathwayREACTOME_REGULATION_OF_PTEN_MRNA_TRANSLATION

TNRC6B TNRC6A

1.14e-039812M27810
PathwayREACTOME_REGULATION_OF_NPAS4_MRNA_TRANSLATION

TNRC6B TNRC6A

1.14e-039812M46436
PathwayREACTOME_INITIAL_TRIGGERING_OF_COMPLEMENT

FCN3 C4A C4B MASP2

1.15e-0380814M6121
PathwayREACTOME_COMPLEMENT_CASCADE

C4A C4B C8A MASP2

1.38e-0384814MM14653
PathwayREACTOME_REGULATION_OF_CDH11_MRNA_TRANSLATION_BY_MICRORNAS

TNRC6B TNRC6A

1.42e-0310812M48013
PathwayWP_COMPLEMENTMEDIATED_INFLAMMATION_OF_PULMONARY_ALVEOLUS_IN_COVID19_HYPOTHETICAL_PATHWAY

C8A MASP2

2.07e-0312812M48316
PathwayBIOCARTA_CLASSIC_PATHWAY

C4A C4B

2.07e-0312812MM1368
PathwayREACTOME_REGULATION_OF_NPAS4_GENE_EXPRESSION

TNRC6B TNRC6A

2.44e-0313812M46434
Pubmed

Diacylglycerol kinase delta regulates protein kinase C and epidermal growth factor receptor signaling.

DGKZ DGKE DGKD DGKK DGKI

1.44e-1011112517021016
Pubmed

Mannan-binding lectin-associated serine protease 2 is critical for the development of renal ischemia reperfusion injury and mediates tissue injury in the absence of complement C4.

C4A C4B MASP2

3.25e-083112324868011
Pubmed

An evolutionarily conserved G-protein coupled receptor family, SREB, expressed in the central nervous system.

GPR27 GPR173 GPR85

3.25e-083112310833454
Pubmed

Targeting of mannan-binding lectin-associated serine protease-2 confers protection from myocardial and gastrointestinal ischemia/reperfusion injury.

C4A C4B MASP2

1.30e-074112321502512
Pubmed

Functional analysis of Ficolin-3 mediated complement activation.

FCN3 C4A C4B

1.30e-074112321085669
Pubmed

Collectin-11 detects stress-induced L-fucose pattern to trigger renal epithelial injury.

C4A C4B MASP2

1.30e-074112327088797
Pubmed

Toward a structure-based comprehension of the lectin pathway of complement.

C4A C4B MASP2

3.24e-075112323911397
Pubmed

Essential role of mannose-binding lectin-associated serine protease-1 in activation of the complement factor D.

C4A C4B MASP2

3.24e-075112320038603
Pubmed

A role for Mac-1 (CDIIb/CD18) in immune complex-stimulated neutrophil function in vivo: Mac-1 deficiency abrogates sustained Fcgamma receptor-dependent neutrophil adhesion and complement-dependent proteinuria in acute glomerulonephritis.

ITGAM C4A C4B

3.24e-07511239382884
Pubmed

The lectin pathway of complement activation is a critical component of the innate immune response to pneumococcal infection.

C4A C4B MASP2

1.13e-067112322792067
Pubmed

C3 opsonization regulates endocytic handling of apoptotic cells resulting in enhanced T-cell responses to cargo-derived antigens.

ITGAM C4A C4B

1.80e-068112324474777
Pubmed

Deficiency of decay-accelerating factor and complement receptor 1-related gene/protein y on murine platelets leads to complement-dependent clearance by the macrophage phagocytic receptor CRIg.

ITGAM C4A C4B

7.00e-0612112318524992
Pubmed

Copy number analysis of complement C4A, C4B and C4A silencing mutation by real-time quantitative polymerase chain reaction.

C4A C4B

1.03e-052112222737222
Pubmed

Deficiency of C4 from donor or recipient mouse fails to prevent renal allograft rejection.

C4A C4B

1.03e-052112216565498
Pubmed

Complete deficiencies of complement C4A and C4B including 2-bp insertion in codon 1213 are genetic risk factors of systemic lupus erythematosus in Thai populations.

C4A C4B

1.03e-052112215998580
Pubmed

Structural polymorphism of murine C4 and its linkage to H-2.

C4A C4B

1.03e-05211227373044
Pubmed

High-throughput analysis of the C4 polymorphism by a combination of MLPA and isotype-specific ELISA's.

C4A C4B

1.03e-052112219062096
Pubmed

The chemical structure of the C4d fragment of the human complement component C4.

C4A C4B

1.03e-05211223696167
Pubmed

Restriction fragment length polymorphism of the murine C4 and Slp genes: two C4 groups.

C4A C4B

1.03e-05211221357031
Pubmed

Structural comparison of human C4A3 and C4B1 after proteolytic activation by C1s.

C4A C4B

1.03e-052112216098595
Pubmed

Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice.

C4A C4B

1.03e-052112219933335
Pubmed

Regulation of DMBT1 via NOD2 and TLR4 in intestinal epithelial cells modulates bacterial recognition and invasion.

NOD2 DMBT1

1.03e-052112217548659
Pubmed

Structural basis for the C4d.1/C4d.2 serologic allotypes of murine complement component C4.

C4A C4B

1.03e-05211222459207
Pubmed

Antigen-induced B cell apoptosis is independent of complement C4.

C4A C4B

1.03e-052112217645767
Pubmed

Role of GW182 protein in the cell.

TNRC6B TNRC6A

1.03e-052112229791863
Pubmed

Increased frequency of C4B*Q0 alleles in patients with Henoch-Schönlein purpura.

C4A C4B

1.03e-052112215787745
Pubmed

Anti-DNA autoreactivity in C4-deficient mice.

C4A C4B

1.03e-052112212207352
Pubmed

Neuropil contraction in relation to Complement C4 gene copy numbers in independent cohorts of adolescent-onset and young adult-onset schizophrenia patients-a pilot study.

C4A C4B

1.03e-052112230026462
Pubmed

A molecular map of the human major histocompatibility complex class III region linking complement genes C4, C2 and factor B.

C4A C4B

1.03e-05211226559257
Pubmed

Complement C4A and C4B Gene Copy Number Study in Alzheimer's Disease Patients.

C4A C4B

1.03e-052112227758680
Pubmed

Genetically determined partial complement C4 deficiency states are not independent risk factors for SLE in UK and Spanish populations.

C4A C4B

1.03e-052112222387014
Pubmed

Complement C4 Is Reduced in iPSC-Derived Astrocytes of Autism Spectrum Disorder Subjects.

C4A C4B

1.03e-052112234299197
Pubmed

Assessment of complement C4 gene copy number using the paralog ratio test.

C4A C4B

1.03e-052112220506482
Pubmed

Ficolin-3 and MASP-2 gene variants in Siberian arctic populations: Summarized evidence of selective pressure for the high frequency of lectin complement pathway deficiency.

FCN3 MASP2

1.03e-052112236574978
Pubmed

Polymerase chain reaction based C4AQ0 and C4BQ0 genotyping: association with systemic lupus erythematosus in southwest Han Chinese.

C4A C4B

1.03e-052112212480675
Pubmed

Low C4, C4A and C4B gene copy numbers are stronger risk factors for juvenile-onset than for adult-onset systemic lupus erythematosus.

C4A C4B

1.03e-052112226800705
Pubmed

Complement C4 maintains peripheral B-cell tolerance in a myeloid cell dependent manner.

C4A C4B

1.03e-052112223749435
Pubmed

Copy number variations of complement component C4 are associated with Behçet's disease but not with ankylosing spondylitis associated with acute anterior uveitis.

C4A C4B

1.03e-052112223918728
Pubmed

Murine complement C4 is not required for experimental autoimmune encephalomyelitis.

C4A C4B

1.03e-052112215390104
Pubmed

Molecular genetics of androgen-dependent and -independent expression of mouse sex-limited protein.

C4A C4B

1.03e-05211223037333
Pubmed

Multiple domains of MASP-2, an initiating complement protease, are required for interaction with its substrate C4.

C4B MASP2

1.03e-052112222071314
Pubmed

Evidence of a role for C4 in modulating interstitial inflammation in experimental glomerulonephritis.

C4A C4B

1.03e-052112211726230
Pubmed

Quantitative variations in the expression of the mouse serum antigen Ss and its sex-limited allotype Slp.

C4A C4B

1.03e-05211224216347
Pubmed

Importance of the alpha 3-fragment of complement C4 for the binding with C4b-binding protein.

C4A C4B

1.03e-05211221699796
Pubmed

Sequence determination of the thiolester site of the fourth component of human complement.

C4A C4B

1.03e-05211226950384
Pubmed

Molecular cloning and characterization of complementary and genomic DNA clones for mouse C4 and Slp.

C4A C4B

1.03e-05211222997024
Pubmed

Endocannabinoids and diacylglycerol kinase activity.

DGKZ DGKE

1.03e-052112221194521
Pubmed

No association of TDP-43 with sporadic frontotemporal dementia.

TARDBP MASP2

1.03e-052112217614162
Pubmed

Visual demonstration of the organization of the human complement C4 and 21-hydroxylase genes by high-resolution fluorescence in situ hybridization.

C4A C4B

1.03e-05211228660986
Pubmed

Constitutive expression of Slp genes in mouse strain B10.WR directed by C4 regulatory sequences.

C4A C4B

1.03e-05211223624865
Pubmed

Tissue-specific RNA processing for the complement C4 gene transcript in the H-2k mouse strain.

C4A C4B

1.03e-05211228428773
Pubmed

Determination of the loss of function complement C4 exon 29 CT insertion using a novel paralog-specific assay in healthy UK and Spanish populations.

C4A C4B

1.03e-052112221857912
Pubmed

A novel assay to quantitate MASP-2/ficolin-3 complexes in serum.

FCN3 MASP2

1.03e-052112223142462
Pubmed

Complement C4 deficiency--a plausible risk factor for non-tuberculous mycobacteria (NTM) infection in apparently immunocompetent patients.

C4A C4B

1.03e-052112224638111
Pubmed

Isolation of cDNA clones specifying the fourth component of mouse complement and its isotype, sex-limited protein.

C4A C4B

1.03e-05211226208559
Pubmed

The role of the histocompatibility-2-linked Ss-Slp region in the control of mouse complement.

C4A C4B

1.03e-05211224514997
Pubmed

Transcriptional repression of C4 complement by hepatitis C virus proteins.

C4A C4B

1.03e-052112221345967
Pubmed

The inheritance of susceptibility to the Gross leukemia virus in mice.

C4A C4B

1.03e-05211225919331
Pubmed

An ancient provirus has imposed androgen regulation on the adjacent mouse sex-limited protein gene.

C4A C4B

1.03e-05211223167981
Pubmed

The dichotomous size variation of human complement C4 genes is mediated by a novel family of endogenous retroviruses, which also establishes species-specific genomic patterns among Old World primates.

C4A C4B

1.03e-05211227545960
Pubmed

Insights on the relationship between complement component C4 serum concentrations and C4 gene copy numbers in a Western Australian systemic lupus erythematosus cohort.

C4A C4B

1.03e-052112230041577
Pubmed

Cleavage of the CD11b extracellular domain by the leukocyte serprocidins is critical for neutrophil detachment during chemotaxis.

ITGAM LYST

1.03e-052112221403131
Pubmed

Restriction fragment analysis of H-2 recombinant mouse strains with crossovers between E alpha and C4 genes.

C4A C4B

1.03e-05211222572548
Pubmed

The complement component C4 of mammals.

C4A C4B

1.03e-05211222302180
Pubmed

Complete cDNA sequence of the fourth component of murine complement.

C4A C4B

1.03e-05211223862104
Pubmed

The BS variant of C4 protects against age-related loss of white matter microstructural integrity.

C4A C4B

1.03e-052112234358307
Pubmed

Acute renal allograft rejection: diagnostic significance of focal peritubular capillary C4d.

C4A C4B

1.03e-052112218360261
Pubmed

Gene CNVs and protein levels of complement C4A and C4B as novel biomarkers for partial disease remissions in new-onset type 1 diabetes patients.

C4A C4B

1.03e-052112222151770
Pubmed

C4d-positive chronic rejection: a frequent entity with a poor outcome.

C4A C4B

1.03e-052112218091514
Pubmed

Comprehensive approach to study complement C4 in systemic lupus erythematosus: Gene polymorphisms, protein levels and functional activity.

C4A C4B

1.03e-052112229080553
Pubmed

Schizophrenia risk from complex variation of complement component 4.

C4A C4B

1.03e-052112226814963
Pubmed

Genes for murine fourth complement component (C4) and sex-limited protein (Slp) identified by hybridization to C4- and Slp-specific cDNA.

C4A C4B

1.03e-05211226589636
Pubmed

C4 Deficiency is a predisposing factor for Streptococcus pneumoniae-induced autoantibody production.

C4A C4B

1.03e-052112225339671
Pubmed

A study of association of the complement C4 mutations with systemic lupus erythematosus in the Malaysian population.

C4A C4B

1.03e-052112217728371
Pubmed

Structure and organization of the C4 genes.

C4A C4B

1.03e-05211226149580
Pubmed

Sequence heterogeneity of murine complementary DNA clones related to the C4 and C4-Slp isoforms of the fourth complement component.

C4A C4B

1.03e-05211226149581
Pubmed

The follicular dendritic cell restricted epitope, FDC-M2, is complement C4; localization of immune complexes in mouse tissues.

C4A C4B

1.03e-052112212115608
Pubmed

Biochemistry and biology of anaphylatoxins.

C4A C4B

1.03e-05211223542363
Pubmed

C4 from C4-high and C4-low mouse strains have identical sequences in the region corresponding to the isotype-specific segment of human C4.

C4A C4B

1.03e-05211222387317
Pubmed

Promoter elements of the mouse complement C4 gene critical for transcription activation and start site location.

C4A C4B

1.03e-05211228132550
Pubmed

Substitution of a single amino acid (aspartic acid for histidine) converts the functional activity of human complement C4B to C4A.

C4A C4B

1.03e-05211222395880
Pubmed

Effects of Complement C4 Gene Copy Number Variations, Size Dichotomy, and C4A Deficiency on Genetic Risk and Clinical Presentation of Systemic Lupus Erythematosus in East Asian Populations.

C4A C4B

1.03e-052112226814708
Pubmed

cDNA clone spanning the alpha-gamma subunit junction in the precursor of the murine fourth complement component (C4).

C4A C4B

1.03e-05211226192448
Pubmed

Complete primary structure of human C4a anaphylatoxin.

C4A C4B

1.03e-05211226167582
Pubmed

Identification of the size and antigenic determinants of the human C4 gene by a polymerase chain-reaction-based amplification method.

C4A C4B

1.03e-052112216908004
Pubmed

Slp is an essential component of an EDTA-resistant activation pathway of mouse complement.

C4A C4B

1.03e-05211221438267
Pubmed

Structural studies on the murine fourth component of complement (C4). IV. Demonstration that C4 and Slp are encoded by separate loci.

C4A C4B

1.03e-05211227365238
Pubmed

Genetic deficiency of complement isoforms C4A or C4B predicts improved survival of metastatic renal cell carcinoma.

C4A C4B

1.03e-052112219150565
Pubmed

Interaction between the labile binding sites of the fourth (C4) and fifth (C5) human complement proteins and erythrocyte cell membranes.

C4A C4B

1.03e-05211227391573
Pubmed

Elevated levels of endogenous apoptotic DNA and IFN-alpha in complement C4-deficient mice: implications for induction of systemic lupus erythematosus.

C4A C4B

1.03e-052112217506029
Pubmed

Peritubular capillary C4d deposition in lupus nephritis different from antibody-mediated renal rejection.

C4A C4B

1.03e-052112217971360
Pubmed

Low C4 gene copy numbers are associated with superior graft survival in patients transplanted with a deceased donor kidney.

C4A C4B

1.03e-052112223715124
Pubmed

Identification of the 5'-flanking regulatory region responsible for the difference in transcriptional control between mouse complement C4 and Slp genes.

C4A C4B

1.03e-05211223464002
Pubmed

Complete nucleotide and derived amino acid sequences of the fourth component of mouse complement (C4). Evolutionary aspects.

C4A C4B

1.03e-05211222993295
Pubmed

Clinical features of patients with homozygous complement C4A or C4B deficiency.

C4A C4B

1.03e-052112229928053
Pubmed

Analysis of C4 and the C4 binding protein in the MRL/lpr mouse.

C4A C4B

1.03e-052112217971229
Pubmed

Inhibition of neutrophil elastase suppresses the development of skin tumors in hairless mice.

LYST HR

1.03e-05211228757756
Pubmed

Genetic deficiency of C4 presenting with recurrent infections and a SLE-like disease. Genetic and immunologic studies.

C4A C4B

1.03e-05211226881182
Pubmed

Identification of the site of sulfation of the fourth component of human complement.

C4A C4B

1.03e-05211223944109
Pubmed

Partial C4 deficiency in juvenile idiopathic arthritis patients.

C4A C4B

1.03e-052112217921792
GeneFamilyEF-hand domain containing|Diacylglycerol kinases

DGKZ DGKE DGKD DGKK DGKI

3.25e-10107851178
GeneFamilyComplement system|Sushi domain containing

ITGAM C4A C4B C8A

1.70e-0536784492
GeneFamilyC3 and PZP like, alpha-2-macroglobulin domain containing

C4A C4B

6.49e-0497821234
GeneFamilyProtein phosphatases, Mg2+/Mn2+ dependent

PPM1L PPM1N

2.40e-0317782701
GeneFamilyCarboxypeptidases

CPA5 CPZ

3.66e-03217821321
GeneFamilyAnkyrin repeat domain containing

SHANK2 ANKRD17 DGKI HECTD1 ARAP1

3.94e-03242785403
GeneFamilyG protein-coupled receptors, Class A orphans

GPR27 GPR173 GPR85

4.66e-0378783262
GeneFamilyAtaxins|Trinucleotide repeat containing

TNRC6B TNRC6A

5.17e-0325782775
GeneFamilyFibrinogen C domain containing

FCN3 TNN

5.17e-0325782554
GeneFamilyWD repeat domain containing

WDR33 FBXW2 LYST DCAF5 PWP2

5.50e-03262785362
GeneFamilySterile alpha motif domain containing

DGKD SHANK2 ARAP1

6.52e-0388783760
GeneFamilyWD repeat domain containing|Caspase recruitment domain containing|Apoptosome

NOD2 CASP12

7.39e-0330782959
ToppCellhuman_hepatoblastoma-Tumor_cells-T2|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

LYST SHANK2 PTPRK FARS2 TNRC6A MAP3K13 C8A

4.80e-071871127f3e37c18ac6471c7992609bbddfa4975571c815c
ToppCellTuft-tuft-1|World / Class top

DGKD SLC5A1 DGKI TSPYL5 C4B DMBT1

4.27e-0616811268ddc2ec483ed2c6c0fb2ae521c6861ceb6d32e34
ToppCellfacs-Marrow-B-cells-18m-Hematologic-MPP_Fraction_B_+_C|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TMEM86B URB2 CD163L1 PWP2 ALPK3 HLTF

6.35e-0618011267368ab31c3273374ef260f0d710d4eea83cbc4a2
ToppCellrenal_cortex_nuclei|World / Celltypes from Cells and Nuclei per compartment and clinical group

TNRC6B ARID1B SHANK2 PTPRK TNRC6A ANKRD17

9.18e-061921126e8cc4d08fcfceeab75a02558817e4ccd7dbafe3a
ToppCellTracheal-NucSeq|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations

TNRC6B ARID1B SHANK2 UBR5 TNRC6A HERC4

1.13e-05199112694b94b17ca18b8dc27b91da1f2ccf89e03cc7035
DrugAC1L4Q08

DGKZ DGKE DGKD DGKI

7.01e-07151114CID000161747
Drug1-stearoyl-2-arachidonoyl-sn-glycerol

NOX5 DGKZ DGKE DGKD DGKI

1.44e-06401115CID000001398
Drug1,2-dicaprin

NOX5 DGKZ DGKE DGKD DGKI

4.04e-06491115CID000001321
Drugdiradylglycerol

NOX5 DGKZ DGKE DGKD DGKI

4.94e-06511115CID006437874
Drug1,3-DCG

NOX5 DGKZ DGKE DGKD NOD2 DGKI

6.73e-06941116CID000150911
DrugDiC8

NOX5 DGKZ DGKE DGKD ITGAM RPS6KA6 DGKI

7.51e-061461117CID000001323
Drugoctylglucopyranoside

NOX5 TM9SF1 DGKZ DGKE DGKD ZBTB32 DGKI

1.54e-051631117CID000062080
DrugR59949

NOX5 DGKZ DGKE DGKD DGKI

2.37e-05701115CID000657356
DiseaseComplement deficiency disease

FCN3 C4A C4B C8A MASP2

1.31e-07331085C0272242
DiseaseAntibody Deficiency Syndrome

FCN3 C4A C8A

3.12e-05171083C0003257
Diseaseresponse to cranial radiation therapy, short-term memory

TMEM86B AGXT2 ARID1B MALRD1

7.07e-05601084EFO_0004335, EFO_0010950
DiseaseImmunologic Deficiency Syndromes

FCN3 C4A C8A

8.01e-05231083C0021051
Diseasebrain measurement, hippocampal volume

ZNF326 MALRD1

1.97e-0461082EFO_0004464, EFO_0005035
DiseaseLarge cell carcinoma of lung

ALPK3 RPS6KA6 MYO18B

2.19e-04321083C0345958
DiseaseX-21448 measurement

DGKD USP40

5.86e-04101082EFO_0800816
Diseasegastric adenocarcinoma (is_implicated_in)

RTEL1 UBR5

7.14e-04111082DOID:3717 (is_implicated_in)
Diseasegamma-glutamylleucine measurement

NALF1 FARS2

1.01e-03131082EFO_0021140
Diseasetriacylglycerol 46:2 measurement

PMPCB DNAJC2

1.17e-03141082EFO_0010402
Diseasesystemic lupus erythematosus (is_implicated_in)

NOD2 C4A C4B

1.54e-03621083DOID:9074 (is_implicated_in)
Diseasebrain infarction

SNX33 ALK

1.95e-03181082EFO_0004277
Diseasetype 2 diabetes mellitus (biomarker_via_orthology)

PCSK1 ITGAM CAPN10 CASP12

2.12e-031471084DOID:9352 (biomarker_via_orthology)
Diseaseblood metabolite measurement

CRAT FOXH1

2.18e-03191082EFO_0005664
DiseaseLupus Erythematosus, Systemic

ITGAM C4A C4B

2.27e-03711083C0024141
Diseaselean body mass

PCSK1 HEXIM2 SOCS2 MST1R DGKI MASP2

2.75e-033791086EFO_0004995

Protein segments in the cluster

PeptideGeneStartEntry
LLSGGTWTQAGQGQL

URB2

211

Q14146
EVQTGFGRLGSHFWG

AGXT2

321

Q9BYV1
VFAAAAAGTQGWQGL

AMOTL2

671

Q9Y2J4
LEARDGHSQLGGWNG

ARSD

361

P51689
QLNTATWGNLTGLGG

CELF2

231

O95319
GSSGWSGGLAQNRST

C8A

426

P07357
AAWLTRQGSFQGGFR

C4B

1286

P0C0L5
NAVGTSSGWNRIGTG

ADORA2A-AS1

46

P86434
QAGRQALAAARGSWG

ALPK3

1251

Q96L96
GGGSRLNSGNRWFDK

CRAT

311

P43155
GSWRVGQTAGGSRNF

CAPN10

521

Q9HC96
EFNSGLLHWQLGGGD

ARID1B

1881

Q8NFD5
HSGIWSFEGIGGNQD

ANKRD17

2456

O75179
SGDATWGLRLVGGSN

CD163L1

576

Q9NR16
RGNGAGIVWFTTDSG

CASP12

221

Q6UXS9
GGGNGSKNWSEDDLQ

DNAJC2

446

Q99543
GGSWALAGNQAIGEL

ARMCX4

1221

Q5H9R4
NQASEGSWAGAGAGN

ARMCX4

1271

Q5H9R4
WANSGDQISGGFLVG

ARMCX4

1426

Q5H9R4
GFLVGIVDQANGGSW

ARMCX4

1436

Q5H9R4
LAVSADGGLFGWGNS

RCC1L

296

Q96I51
LLLDAAGQVFSWGGG

RCCD1

171

A6NED2
WGGNNGSTLTAAVLA

ISYNA1

66

Q9NPH2
ARQGASAGTEWGAGA

NOX5

111

Q96PH1
GRNSGPNRAQGSWAT

CACNA1F

1826

O60840
EGGGWLVFQRRQDGS

FCN3

126

O75636
ANTLIGNWDRSFGGG

PMPCB

316

O75439
GNWDRSFGGGMNLSS

PMPCB

321

O75439
LGTGNDLARVLGWGA

DGKK

576

Q5KSL6
WQNGGARGAFAKDLG

FOXH1

131

O75593
RGLIRTGGWFDGTQQ

MGAT3

456

Q09327
DRGQLFSWGAGSDGQ

HERC3

101

Q15034
GLSGLLNASGGSWRE

FAM89B

26

Q8N5H3
IGVDLNRNWKSGFGG

CPA5

266

Q8WXQ8
LQGNLWGTEALGALG

HR

881

O43593
GPGATGQAAANWTAG

GPR27

231

Q9NS67
GQAAANWTAGFGRGP

GPR27

236

Q9NS67
TLSGAIFGWGRNKFG

HERC4

206

Q5GLZ8
IFGWGRNKFGQLGLN

HERC4

211

Q5GLZ8
ASGGLRFGASAAQGW

PPM1N

61

Q8N819
FSNNGGQWLVSGGDD

DCAF5

61

Q96JK2
GINQGQRSSGGGDHW

RIPPLY3

156

P57055
LSTAQGAISRGLGGW

EHBP1L1

546

Q8N3D4
IARDVAGATWGNGSG

GNL1

311

P36915
RIGNGKFSLSGGNWD

RPS6KA6

636

Q9UK32
GGLDASGANLWASAN

MSLNL

41

Q96KJ4
WNRGQTGANGGRKFL

KLHL5

86

Q96PQ7
LWARTGGGGEAAAYN

LRIT1

361

Q9P2V4
ATGFGQGNIRALWQS

HPDL

346

Q96IR7
LQWLGSGAQGAVFLG

MAP3K13

171

O43283
DSNTFRWGLGNGISI

MALRD1

1111

Q5VYJ5
LSNGSNGWFRFILDG

HECTD1

686

Q9ULT8
GFGDGFWRQRDLDSN

GRHL3

596

Q8TE85
QRQGGWSTDGGGRLL

DACT2

366

Q5SW24
AEGAGYNGWTSGRQN

CPZ

301

Q66K79
NLSWTGNRGFISVAG

FBXL4

351

Q9UKA2
LGTGNDLARTLNWGG

DGKI

461

O75912
GGGSDLRLWTVNGDL

LYST

3681

Q99698
GATGQAAANWIAGFG

GPR173

236

Q9NS66
DIGTASGWGLTQRGF

MASP2

566

O00187
LGTGNDLARVLGWGS

DGKD

406

Q16760
SGQAAANWLAGFGRG

GPR85

236

P60893
KTLGFNLESGWGSGR

HLTF

176

Q14527
GTGNDLSNTLGWGTG

DGKE

311

P52429
GTGNDLARTLNWGGG

DGKZ

381

Q13574
SGEGFNVNVAWAGGL

HDAC7

751

Q8WUI4
RGSSFLAGEASWLNG

FBXW2

411

Q9UKT8
GWATSAPGNARFGQG

DMBT1

646

Q9UGM3
GWATSAPGNARFGQG

DMBT1

906

Q9UGM3
WATSAPGNARFGQGS

DMBT1

1296

Q9UGM3
WGLPFLNGTEANGTG

SLC22A6

86

Q4U2R8
GLWLSLGGFHERGQD

NIT1

121

Q86X76
RAGAQAAGSTWLQGF

MFSD14C

26

Q5VZR4
RAGAQAAGSTWLQGF

MFSD14B

26

Q5SR56
SAWLTRQGSFQGGFR

C4A

1286

P0C0L4
WPLLGSAQGQFSAGG

PTPRK

21

Q15262
RGGEGLLSSQHQWQF

PHF20

926

Q9BVI0
GAGGQFLSGQEWYRQ

RTEL1

671

Q9NZ71
NTGRSQGGWSYRDGN

SPATA22

101

Q8NHS9
GSNSGAAIGWGSASN

TARDBP

376

Q13148
EDLAGAVGGLGWNSR

HEXIM2

56

Q96MH2
GGFISFNGSWRVQGI

PPM1L

246

Q5SGD2
LEPSGNGGEGTRSQW

SOCS2

6

O14508
DGWLQGQNSRGETGL

SNX33

36

Q8WV41
QEGGFRSLWRGNGIN

SLC25A41

141

Q8N5S1
AAGGLAVGGFEWNAT

SLC5A9

101

Q2M3M2
GEQGQPWGRFGAALT

ITGAM

511

P11215
NFFRAWNGGFSGNLE

PRXL2A

161

Q9BRX8
WNGGFSGNLEGEGFI

PRXL2A

166

Q9BRX8
GVRALSLGGQVWGNF

SV2A

421

Q7L0J3
GGVAWQAGLRTGDFL

SHANK2

671

Q9UPX8
AAGGGGGWNDNTSLL

ALK

876

Q9UM73
LQLGNGAGNRFWAAN

ARAP1

606

Q96P48
QWRANPSRGGGGVSF

STK19

16

P49842
VGQRWEQGRSFGSLA

TTC24

306

A2A3L6
LNWQGGGGDAASSQE

TRAPPC11

701

Q7Z392
LQFLGFWGNRVGDEG

NOD2

901

Q9HC29
GGEASLQGCRWGANG

RNF112

206

Q9ULX5
GGGWIVFQRRNTGQL

TNN

1106

Q9UQP3
RANEQGAFWGLIAGL

SLC5A10

466

A0PJK1
SGDWIAFGCSGLGQL

PWP2

341

Q15269
GAGNNWAKGRYTEGA

TUBB8B

96

A6NNZ2
LAQGGSAGWGALLFT

TMEM86B

166

Q8N661
GGGAQDARGLFWVLD

MYO18B

1026

Q8IUG5
ARNGAGPEWGGFEEN

YIPF3

11

Q9GZM5
GNRWGGCADNLSYGL

WNT11

151

O96014
LGWGSEAAGFQESRG

TMEM204

76

Q9BSN7
SQQLGRRGQWALGEG

ZBTB32

51

Q9Y2Y4
GGRSGSNWGRGSNMN

WDR33

1306

Q9C0J8
GAASGIAIGGFEWNA

SLC5A1

91

P13866
SAGAQDRIGWAFGLG

FARS2

301

O95363
WNAAQGGTAGSLRQR

USP40

1091

Q9NVE5
GWVAGNLSARGDGAA

MST1R

836

Q04912
NTNKGGGVWESGAAN

TNRC6A

566

Q8NDV7
QQLGIQGLGLDSGSW

ZNF282

11

Q9UDV7
SAGSGDDFDQGDNGW

TM9SF1

276

O15321
GQNEIGTWGNGGNAS

TNRC6B

776

Q9UPQ9
GRLAGNTLGSRWSSG

UBR5

121

O95071
ALAQQWRGTSSGFGR

VWA5B1

931

Q5TIE3
AQVQAGAGWGGLEAA

TSPYL5

51

Q86VY4
GAGWGGLEAAASAQL

TSPYL5

56

Q86VY4
SFGGRNQGGSSWEAP

ZNF326

121

Q5BKZ1
CARNWSRGAAGGDGQ

NALF1

191

B1AL88
RQGKGSIFVWASGNG

PCSK1

296

P29120
SIFVWASGNGGRQGD

PCSK1

301

P29120