Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	somatodendritic compartment	CACNA1B RIN3 CSF1R DRP2 PNMT ZPR1 NTRK2 APBA1 C4A C4B ELK1 GNAS MAGEE1 LMTK3 TIAM2 HRH3 NRP1	3.99e-05	1228	96	17	GO:0036477
GeneOntologyCellularComponent	neuronal cell body	CACNA1B RIN3 CSF1R DRP2 PNMT ZPR1 NTRK2 C4A C4B ELK1 GNAS TIAM2 NRP1	1.13e-04	835	96	13	GO:0043025
GeneOntologyCellularComponent	dendrite	CACNA1B RIN3 DRP2 PNMT NTRK2 APBA1 C4A C4B ELK1 GNAS MAGEE1 LMTK3 HRH3	1.48e-04	858	96	13	GO:0030425
GeneOntologyCellularComponent	dendritic tree	CACNA1B RIN3 DRP2 PNMT NTRK2 APBA1 C4A C4B ELK1 GNAS MAGEE1 LMTK3 HRH3	1.52e-04	860	96	13	GO:0097447
GeneOntologyCellularComponent	cell body	CACNA1B RIN3 CSF1R DRP2 PNMT ZPR1 NTRK2 C4A C4B ELK1 GNAS TIAM2 NRP1	3.21e-04	929	96	13	GO:0044297
GeneOntologyCellularComponent	symbiont cell surface	C4A C4B	5.74e-04	8	96	2	GO:0106139
GeneOntologyCellularComponent	BRCA1-A complex	BARD1 MPND	5.74e-04	8	96	2	GO:0070531
GeneOntologyCellularComponent	perikaryon	CSF1R DRP2 PNMT ZPR1 NTRK2 TIAM2	5.75e-04	223	96	6	GO:0043204
GeneOntologyCellularComponent	other organism part	C4A C4B	7.36e-04	9	96	2	GO:0044217
GeneOntologyCellularComponent	axon	CACNA1B RIN3 PNMT ZPR1 NTRK2 C4A C4B ELK1 MAP7 LMTK3 TIAM2 NRP1	7.76e-04	891	96	12	GO:0030424
GeneOntologyCellularComponent	ubiquitin ligase complex	RNF144B RANBP10 MED30 UBE2D2 UBE2D3 NEURL2 BARD1	1.20e-03	352	96	7	GO:0000151
Domain	DUF4074	HOXB3 HOXD3	7.33e-05	3	93	2	IPR025281
Domain	DUF4074	HOXB3 HOXD3	7.33e-05	3	93	2	PF13293
Domain	C345C	NTN1 C4A C4B	7.73e-05	17	93	3	SM00643
Domain	NTR	NTN1 C4A C4B	1.09e-04	19	93	3	PF01759
Domain	Netrin_module_non-TIMP	NTN1 C4A C4B	1.09e-04	19	93	3	IPR018933
Domain	NTR	NTN1 C4A C4B	1.97e-04	23	93	3	PS50189
Domain	Netrin_domain	NTN1 C4A C4B	1.97e-04	23	93	3	IPR001134
Domain	Anaphylatoxin_comp_syst	C4A C4B	2.43e-04	5	93	2	IPR018081
Domain	Anaphylatoxn_comp_syst_dom	C4A C4B	2.43e-04	5	93	2	IPR001840
Domain	TIMP-like_OB-fold	NTN1 C4A C4B	2.86e-04	26	93	3	IPR008993
Domain	Homeobox_CS	HOXB3 HOXD3 HMX3 NKX1-1 SIX5 LHX3	3.35e-04	186	93	6	IPR017970
Domain	ANATO	C4A C4B	5.07e-04	7	93	2	SM00104
Domain	DM	DMRT2 DMRTB1	5.07e-04	7	93	2	PF00751
Domain	DM_2	DMRT2 DMRTB1	5.07e-04	7	93	2	PS50809
Domain	ANATO	C4A C4B	5.07e-04	7	93	2	PF01821
Domain	DM	DMRT2 DMRTB1	5.07e-04	7	93	2	SM00301
Domain	-	DMRT2 DMRTB1	5.07e-04	7	93	2	4.10.1040.10
Domain	DM_1	DMRT2 DMRTB1	5.07e-04	7	93	2	PS40000
Domain	ANAPHYLATOXIN_2	C4A C4B	5.07e-04	7	93	2	PS01178
Domain	ANAPHYLATOXIN_1	C4A C4B	5.07e-04	7	93	2	PS01177
Domain	DM_DNA-bd	DMRT2 DMRTB1	5.07e-04	7	93	2	IPR001275
Domain	Anaphylatoxin/fibulin	C4A C4B	5.07e-04	7	93	2	IPR000020
Domain	DMRT/dsx/mab-3	DMRT2 DMRTB1	6.74e-04	8	93	2	IPR026607
Domain	Thiol-ester_cl	C4A C4B	6.74e-04	8	93	2	PF10569
Domain	MacrogloblnA2_thiol-ester-bond	C4A C4B	6.74e-04	8	93	2	IPR019565
Domain	MacrogloblnA2_CS	C4A C4B	6.74e-04	8	93	2	IPR019742
Domain	Homeobox_metazoa	HOXB3 HOXD3 HMX3 NKX1-1	1.06e-03	90	93	4	IPR020479
Domain	A2M_N	C4A C4B	1.08e-03	10	93	2	PF01835
Domain	A2M_N	C4A C4B	1.08e-03	10	93	2	IPR002890
Domain	A-macroglobulin_rcpt-bd	C4A C4B	1.08e-03	10	93	2	IPR009048
Domain	ALPHA_2_MACROGLOBULIN	C4A C4B	1.08e-03	10	93	2	PS00477
Domain	A2M	C4A C4B	1.08e-03	10	93	2	PF00207
Domain	A2M_N_2	C4A C4B	1.08e-03	10	93	2	IPR011625
Domain	A2M_comp	C4A C4B	1.08e-03	10	93	2	IPR011626
Domain	A2M_N_2	C4A C4B	1.08e-03	10	93	2	PF07703
Domain	A2M_recep	C4A C4B	1.08e-03	10	93	2	PF07677
Domain	A2M_comp	C4A C4B	1.08e-03	10	93	2	PF07678
Domain	Macroglobln_a2	C4A C4B	1.08e-03	10	93	2	IPR001599
Domain	Homeobox	HOXB3 HOXD3 HMX3 NKX1-1 SIX5 LHX3	1.12e-03	234	93	6	PF00046
Domain	HOMEOBOX_1	HOXB3 HOXD3 HMX3 NKX1-1 SIX5 LHX3	1.17e-03	236	93	6	PS00027
Domain	HOX	HOXB3 HOXD3 HMX3 NKX1-1 SIX5 LHX3	1.19e-03	237	93	6	SM00389
Domain	HOMEOBOX_2	HOXB3 HOXD3 HMX3 NKX1-1 SIX5 LHX3	1.24e-03	239	93	6	PS50071
Domain	Homeobox_dom	HOXB3 HOXD3 HMX3 NKX1-1 SIX5 LHX3	1.24e-03	239	93	6	IPR001356
Domain	Galactose-bd-like	LAMB2 NTN1 SSPOP NRP1	1.25e-03	94	93	4	IPR008979
Domain	Laminin_N	LAMB2 NTN1	2.81e-03	16	93	2	IPR008211
Domain	LAMININ_NTER	LAMB2 NTN1	2.81e-03	16	93	2	PS51117
Domain	Laminin_N	LAMB2 NTN1	2.81e-03	16	93	2	PF00055
Domain	LamNT	LAMB2 NTN1	2.81e-03	16	93	2	SM00136
Domain	Terpenoid_cyclase/PrenylTrfase	C4A C4B	3.56e-03	18	93	2	IPR008930
Domain	FA58C	SSPOP NRP1	4.84e-03	21	93	2	SM00231
Domain	Homeobox_Antennapedia_CS	HOXB3 HOXD3	4.84e-03	21	93	2	IPR001827
Domain	FA58C_3	SSPOP NRP1	4.84e-03	21	93	2	PS50022
Domain	FA58C_1	SSPOP NRP1	4.84e-03	21	93	2	PS01285
Domain	FA58C_2	SSPOP NRP1	4.84e-03	21	93	2	PS01286
Pubmed	A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system.	RNF144B RNF113B UBE2D2 UBE2D3 BARD1 RFWD3	9.70e-07	118	96	6	19690564
Pubmed	Copy number analysis of complement C4A, C4B and C4A silencing mutation by real-time quantitative polymerase chain reaction.	C4A C4B	7.54e-06	2	96	2	22737222
Pubmed	Deficiency of C4 from donor or recipient mouse fails to prevent renal allograft rejection.	C4A C4B	7.54e-06	2	96	2	16565498
Pubmed	Complete deficiencies of complement C4A and C4B including 2-bp insertion in codon 1213 are genetic risk factors of systemic lupus erythematosus in Thai populations.	C4A C4B	7.54e-06	2	96	2	15998580
Pubmed	Structural polymorphism of murine C4 and its linkage to H-2.	C4A C4B	7.54e-06	2	96	2	7373044
Pubmed	High-throughput analysis of the C4 polymorphism by a combination of MLPA and isotype-specific ELISA's.	C4A C4B	7.54e-06	2	96	2	19062096
Pubmed	The chemical structure of the C4d fragment of the human complement component C4.	C4A C4B	7.54e-06	2	96	2	3696167
Pubmed	Restriction fragment length polymorphism of the murine C4 and Slp genes: two C4 groups.	C4A C4B	7.54e-06	2	96	2	1357031
Pubmed	Structural comparison of human C4A3 and C4B1 after proteolytic activation by C1s.	C4A C4B	7.54e-06	2	96	2	16098595
Pubmed	Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice.	C4A C4B	7.54e-06	2	96	2	19933335
Pubmed	Structural basis for the C4d.1/C4d.2 serologic allotypes of murine complement component C4.	C4A C4B	7.54e-06	2	96	2	2459207
Pubmed	Antigen-induced B cell apoptosis is independent of complement C4.	C4A C4B	7.54e-06	2	96	2	17645767
Pubmed	Increased frequency of C4B*Q0 alleles in patients with Henoch-Schönlein purpura.	C4A C4B	7.54e-06	2	96	2	15787745
Pubmed	Anti-DNA autoreactivity in C4-deficient mice.	C4A C4B	7.54e-06	2	96	2	12207352
Pubmed	Neuropil contraction in relation to Complement C4 gene copy numbers in independent cohorts of adolescent-onset and young adult-onset schizophrenia patients-a pilot study.	C4A C4B	7.54e-06	2	96	2	30026462
Pubmed	Synaptic targeting of N-type calcium channels in hippocampal neurons.	CACNA1B APBA1	7.54e-06	2	96	2	12177192
Pubmed	A molecular map of the human major histocompatibility complex class III region linking complement genes C4, C2 and factor B.	C4A C4B	7.54e-06	2	96	2	6559257
Pubmed	Complement C4A and C4B Gene Copy Number Study in Alzheimer's Disease Patients.	C4A C4B	7.54e-06	2	96	2	27758680
Pubmed	Genetically determined partial complement C4 deficiency states are not independent risk factors for SLE in UK and Spanish populations.	C4A C4B	7.54e-06	2	96	2	22387014
Pubmed	Complement C4 Is Reduced in iPSC-Derived Astrocytes of Autism Spectrum Disorder Subjects.	C4A C4B	7.54e-06	2	96	2	34299197
Pubmed	Assessment of complement C4 gene copy number using the paralog ratio test.	C4A C4B	7.54e-06	2	96	2	20506482
Pubmed	Polymerase chain reaction based C4AQ0 and C4BQ0 genotyping: association with systemic lupus erythematosus in southwest Han Chinese.	C4A C4B	7.54e-06	2	96	2	12480675
Pubmed	Low C4, C4A and C4B gene copy numbers are stronger risk factors for juvenile-onset than for adult-onset systemic lupus erythematosus.	C4A C4B	7.54e-06	2	96	2	26800705
Pubmed	Complement C4 maintains peripheral B-cell tolerance in a myeloid cell dependent manner.	C4A C4B	7.54e-06	2	96	2	23749435
Pubmed	Copy number variations of complement component C4 are associated with Behçet's disease but not with ankylosing spondylitis associated with acute anterior uveitis.	C4A C4B	7.54e-06	2	96	2	23918728
Pubmed	Murine complement C4 is not required for experimental autoimmune encephalomyelitis.	C4A C4B	7.54e-06	2	96	2	15390104
Pubmed	Molecular genetics of androgen-dependent and -independent expression of mouse sex-limited protein.	C4A C4B	7.54e-06	2	96	2	3037333
Pubmed	Evidence of a role for C4 in modulating interstitial inflammation in experimental glomerulonephritis.	C4A C4B	7.54e-06	2	96	2	11726230
Pubmed	Quantitative variations in the expression of the mouse serum antigen Ss and its sex-limited allotype Slp.	C4A C4B	7.54e-06	2	96	2	4216347
Pubmed	Importance of the alpha 3-fragment of complement C4 for the binding with C4b-binding protein.	C4A C4B	7.54e-06	2	96	2	1699796
Pubmed	Sequence determination of the thiolester site of the fourth component of human complement.	C4A C4B	7.54e-06	2	96	2	6950384
Pubmed	Molecular cloning and characterization of complementary and genomic DNA clones for mouse C4 and Slp.	C4A C4B	7.54e-06	2	96	2	2997024
Pubmed	Visual demonstration of the organization of the human complement C4 and 21-hydroxylase genes by high-resolution fluorescence in situ hybridization.	C4A C4B	7.54e-06	2	96	2	8660986
Pubmed	Constitutive expression of Slp genes in mouse strain B10.WR directed by C4 regulatory sequences.	C4A C4B	7.54e-06	2	96	2	3624865
Pubmed	Tissue-specific RNA processing for the complement C4 gene transcript in the H-2k mouse strain.	C4A C4B	7.54e-06	2	96	2	8428773
Pubmed	Determination of the loss of function complement C4 exon 29 CT insertion using a novel paralog-specific assay in healthy UK and Spanish populations.	C4A C4B	7.54e-06	2	96	2	21857912
Pubmed	Complement C4 deficiency--a plausible risk factor for non-tuberculous mycobacteria (NTM) infection in apparently immunocompetent patients.	C4A C4B	7.54e-06	2	96	2	24638111
Pubmed	Isolation of cDNA clones specifying the fourth component of mouse complement and its isotype, sex-limited protein.	C4A C4B	7.54e-06	2	96	2	6208559
Pubmed	The role of the histocompatibility-2-linked Ss-Slp region in the control of mouse complement.	C4A C4B	7.54e-06	2	96	2	4514997
Pubmed	Transcriptional repression of C4 complement by hepatitis C virus proteins.	C4A C4B	7.54e-06	2	96	2	21345967
Pubmed	The inheritance of susceptibility to the Gross leukemia virus in mice.	C4A C4B	7.54e-06	2	96	2	5919331
Pubmed	An ancient provirus has imposed androgen regulation on the adjacent mouse sex-limited protein gene.	C4A C4B	7.54e-06	2	96	2	3167981
Pubmed	The dichotomous size variation of human complement C4 genes is mediated by a novel family of endogenous retroviruses, which also establishes species-specific genomic patterns among Old World primates.	C4A C4B	7.54e-06	2	96	2	7545960
Pubmed	Insights on the relationship between complement component C4 serum concentrations and C4 gene copy numbers in a Western Australian systemic lupus erythematosus cohort.	C4A C4B	7.54e-06	2	96	2	30041577
Pubmed	Restriction fragment analysis of H-2 recombinant mouse strains with crossovers between E alpha and C4 genes.	C4A C4B	7.54e-06	2	96	2	2572548
Pubmed	The complement component C4 of mammals.	C4A C4B	7.54e-06	2	96	2	2302180
Pubmed	Complete cDNA sequence of the fourth component of murine complement.	C4A C4B	7.54e-06	2	96	2	3862104
Pubmed	The BS variant of C4 protects against age-related loss of white matter microstructural integrity.	C4A C4B	7.54e-06	2	96	2	34358307
Pubmed	Acute renal allograft rejection: diagnostic significance of focal peritubular capillary C4d.	C4A C4B	7.54e-06	2	96	2	18360261
Pubmed	Gene CNVs and protein levels of complement C4A and C4B as novel biomarkers for partial disease remissions in new-onset type 1 diabetes patients.	C4A C4B	7.54e-06	2	96	2	22151770
Pubmed	C4d-positive chronic rejection: a frequent entity with a poor outcome.	C4A C4B	7.54e-06	2	96	2	18091514
Pubmed	Comprehensive approach to study complement C4 in systemic lupus erythematosus: Gene polymorphisms, protein levels and functional activity.	C4A C4B	7.54e-06	2	96	2	29080553
Pubmed	Schizophrenia risk from complex variation of complement component 4.	C4A C4B	7.54e-06	2	96	2	26814963
Pubmed	Genes for murine fourth complement component (C4) and sex-limited protein (Slp) identified by hybridization to C4- and Slp-specific cDNA.	C4A C4B	7.54e-06	2	96	2	6589636
Pubmed	C4 Deficiency is a predisposing factor for Streptococcus pneumoniae-induced autoantibody production.	C4A C4B	7.54e-06	2	96	2	25339671
Pubmed	A study of association of the complement C4 mutations with systemic lupus erythematosus in the Malaysian population.	C4A C4B	7.54e-06	2	96	2	17728371
Pubmed	Structure and organization of the C4 genes.	C4A C4B	7.54e-06	2	96	2	6149580
Pubmed	Sequence heterogeneity of murine complementary DNA clones related to the C4 and C4-Slp isoforms of the fourth complement component.	C4A C4B	7.54e-06	2	96	2	6149581
Pubmed	The follicular dendritic cell restricted epitope, FDC-M2, is complement C4; localization of immune complexes in mouse tissues.	C4A C4B	7.54e-06	2	96	2	12115608
Pubmed	Biochemistry and biology of anaphylatoxins.	C4A C4B	7.54e-06	2	96	2	3542363
Pubmed	C4 from C4-high and C4-low mouse strains have identical sequences in the region corresponding to the isotype-specific segment of human C4.	C4A C4B	7.54e-06	2	96	2	2387317
Pubmed	Promoter elements of the mouse complement C4 gene critical for transcription activation and start site location.	C4A C4B	7.54e-06	2	96	2	8132550
Pubmed	Substitution of a single amino acid (aspartic acid for histidine) converts the functional activity of human complement C4B to C4A.	C4A C4B	7.54e-06	2	96	2	2395880
Pubmed	Effects of Complement C4 Gene Copy Number Variations, Size Dichotomy, and C4A Deficiency on Genetic Risk and Clinical Presentation of Systemic Lupus Erythematosus in East Asian Populations.	C4A C4B	7.54e-06	2	96	2	26814708
Pubmed	cDNA clone spanning the alpha-gamma subunit junction in the precursor of the murine fourth complement component (C4).	C4A C4B	7.54e-06	2	96	2	6192448
Pubmed	Complete primary structure of human C4a anaphylatoxin.	C4A C4B	7.54e-06	2	96	2	6167582
Pubmed	Identification of the size and antigenic determinants of the human C4 gene by a polymerase chain-reaction-based amplification method.	C4A C4B	7.54e-06	2	96	2	16908004
Pubmed	Slp is an essential component of an EDTA-resistant activation pathway of mouse complement.	C4A C4B	7.54e-06	2	96	2	1438267
Pubmed	Structural studies on the murine fourth component of complement (C4). IV. Demonstration that C4 and Slp are encoded by separate loci.	C4A C4B	7.54e-06	2	96	2	7365238
Pubmed	Genetic deficiency of complement isoforms C4A or C4B predicts improved survival of metastatic renal cell carcinoma.	C4A C4B	7.54e-06	2	96	2	19150565
Pubmed	Interaction between the labile binding sites of the fourth (C4) and fifth (C5) human complement proteins and erythrocyte cell membranes.	C4A C4B	7.54e-06	2	96	2	7391573
Pubmed	Elevated levels of endogenous apoptotic DNA and IFN-alpha in complement C4-deficient mice: implications for induction of systemic lupus erythematosus.	C4A C4B	7.54e-06	2	96	2	17506029
Pubmed	Peritubular capillary C4d deposition in lupus nephritis different from antibody-mediated renal rejection.	C4A C4B	7.54e-06	2	96	2	17971360
Pubmed	Low C4 gene copy numbers are associated with superior graft survival in patients transplanted with a deceased donor kidney.	C4A C4B	7.54e-06	2	96	2	23715124
Pubmed	Identification of the 5'-flanking regulatory region responsible for the difference in transcriptional control between mouse complement C4 and Slp genes.	C4A C4B	7.54e-06	2	96	2	3464002
Pubmed	Complete nucleotide and derived amino acid sequences of the fourth component of mouse complement (C4). Evolutionary aspects.	C4A C4B	7.54e-06	2	96	2	2993295
Pubmed	Clinical features of patients with homozygous complement C4A or C4B deficiency.	C4A C4B	7.54e-06	2	96	2	29928053
Pubmed	Analysis of C4 and the C4 binding protein in the MRL/lpr mouse.	C4A C4B	7.54e-06	2	96	2	17971229
Pubmed	Genetic deficiency of C4 presenting with recurrent infections and a SLE-like disease. Genetic and immunologic studies.	C4A C4B	7.54e-06	2	96	2	6881182
Pubmed	Identification of the site of sulfation of the fourth component of human complement.	C4A C4B	7.54e-06	2	96	2	3944109
Pubmed	Partial C4 deficiency in juvenile idiopathic arthritis patients.	C4A C4B	7.54e-06	2	96	2	17921792
Pubmed	Complement activation and complement receptors on follicular dendritic cells are critical for the function of a targeted adjuvant.	C4A C4B	7.54e-06	2	96	2	21880985
Pubmed	Amino acid sequence around the thiol and reactive acyl groups of human complement component C4.	C4A C4B	7.54e-06	2	96	2	6978711
Pubmed	Plasma Complement 3 and Complement 4 Are Promising Biomarkers for Distinguishing NMOSD From MOGAD and Are Associated With the Blood-Brain-Barrier Disruption in NMOSD.	C4A C4B	7.54e-06	2	96	2	35898513
Pubmed	Overexpression of schizophrenia susceptibility factor human complement C4A promotes excessive synaptic loss and behavioral changes in mice.	C4A C4B	7.54e-06	2	96	2	33353966
Pubmed	Sequence comparison of alleles of the fourth component of complement (C4) and sex-limited protein (Slp).	C4A C4B	7.54e-06	2	96	2	3008092
Pubmed	Borrelia burgdorferi outer surface protein C (OspC) binds complement component C4b and confers bloodstream survival.	C4A C4B	7.54e-06	2	96	2	28873507
Pubmed	The molecular basis for the difference in immune hemolysis activity of the Chido and Rodgers isotypes of human complement component C4.	C4A C4B	7.54e-06	2	96	2	6609966
Pubmed	Heterogeneity and linkage of equine C4 and steroid 21-hydroxylase genes.	C4A C4B	7.54e-06	2	96	2	2900855
Pubmed	Studies on the murine Ss protein: demonstration that the Ss protein is functionally the fourth component of complement.	C4A C4B	7.54e-06	2	96	2	276882
Pubmed	Amino acid sequence of a polymorphic segment from fragment C4d of human complement component C4.	C4A C4B	7.54e-06	2	96	2	6832377
Pubmed	Recombination of two homologous MHC class III genes of the mouse (C4 and Slp) that accounts for the loss of testosterone dependence of sex-limited protein expression.	C4A C4B	7.54e-06	2	96	2	3794341
Pubmed	Complement and c4 null alleles in severe chronic adult periodontitis.	C4A C4B	7.54e-06	2	96	2	17257223
Pubmed	Three extra copies of a C4-related gene in H-2w7 mice are C4/Slp hybrid genes generated by multiple recombinational events.	C4A C4B	7.54e-06	2	96	2	2272665
Pubmed	Multiple C4/Slp genes distinguished by expression after transfection.	C4A C4B	7.54e-06	2	96	2	3023818
Pubmed	Mutation analysis of Netrin 1 and HMX3 genes in patients with superior semicircular canal dehiscence syndrome.	HMX3 NTN1	7.54e-06	2	96	2	22779713
Pubmed	Fine-tuned characterization of RCCX copy number variants and their relationship with extended MHC haplotypes.	C4A C4B	7.54e-06	2	96	2	22785613
Pubmed	Association between complement 4 copy number variation and systemic lupus erythematosus: a meta-analysis.	C4A C4B	7.54e-06	2	96	2	32691186
Pubmed	Genetic deficiency in complement component 4b does not alter radiation-induced lung disease in mice.	C4A C4B	7.54e-06	2	96	2	23259761
Pubmed	Lack of evidence of a specific role for C4A gene deficiency in determining disease susceptibility among C4-deficient patients with systemic lupus erythematosus (SLE).	C4A C4B	7.54e-06	2	96	2	11168010
GeneFamily	Receptor Tyrosine Kinases\|CD molecules	CSF1R NTRK2 LMTK3	3.63e-04	40	63	3	321
GeneFamily	C3 and PZP like, alpha-2-macroglobulin domain containing	C4A C4B	4.23e-04	9	63	2	1234
GeneFamily	Polypeptide N-acetylgalactosaminyltransferases	GALNTL6 GALNT10	2.18e-03	20	63	2	433
Coexpression	BENPORATH_SUZ12_TARGETS	ZFYVE28 CACNA1B HOXB3 RIN3 DMRT2 HOXD3 GGN NTRK2 HMX3 POMC SIX5 NTN1 CLIC6 GNAS NRP1	4.59e-06	1035	95	15	M9898
Coexpression	HUTTMANN_B_CLL_POOR_SURVIVAL_UP	ZSCAN32 RIN3 EHBP1L1 FADS1 ARHGEF1 NCAN C1orf159 C4A	9.26e-06	284	95	8	M19993
Coexpression	PEREZ_TP53_TARGETS	RNF144B ZFYVE28 ZNF750 GALNT10 ADO NEURL2 CGAS NTN1 C4A LHX3 GNAS CHST2 MAGEE1 MAP7 MN1	2.66e-05	1201	95	15	M4391
Coexpression	GSE13547_CTRL_VS_ANTI_IGM_STIM_BCELL_2H_DN	ACTL7B GALNT10 BTBD6 SSPOP MN1 SH2B1	3.44e-05	168	95	6	M2991
ToppCell	facs-Marrow-T-cells-3m-Myeloid-promonocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EHBP1L1 CSF1R APBA1 HAL TIAM2 NRP1	1.86e-06	170	96	6	a78d9789c3e7c84a36e1bd380192d7aba4a4d443
ToppCell	facs-Marrow-T-cells-3m-Myeloid-monocyte_+_promonocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EHBP1L1 CSF1R APBA1 HAL TIAM2 NRP1	1.86e-06	170	96	6	ff68600b945b3a5437b14e5411b3db800d0ccbe5
ToppCell	Fetal_29-31_weeks-Immune-monocyte\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	RNF144B RIN3 EHBP1L1 CSF1R OSCAR ARHGAP30	4.36e-06	197	96	6	48a8169a4d33c6a68d66bcd936861c75cb4b60ef
ToppCell	COVID-19-lung-Macrophage_VCANhi_FCN1hi\|COVID-19 / Disease (COVID-19 only), tissue and cell type	RNF144B RIN3 EHBP1L1 CSF1R OSCAR ARHGAP30	4.49e-06	198	96	6	ea34096bee852a7e996f097fa279381afa8f86ff
ToppCell	kidney_cells-Adult_normal_reference-Immune-Myeloid-Monocytic-Non-classical_Monocyte\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	RNF144B RIN3 CSF1R OSCAR ARHGAP30 HAL	4.62e-06	199	96	6	0a9783808528bc4c6d797d849a9177330c8fb867
Disease	level of triacylglycerol (56:6) in blood serum	FADS1 ZPR1 NCAN	1.54e-05	16	91	3	OBA_2020007
Disease	triacylglycerol 56:7 measurement	FADS1 ZPR1 NCAN	9.78e-05	29	91	3	EFO_0010434
Disease	1-stearoyl-2-linoleoyl-GPC (18:0/18:2) measurement	FADS1 ZPR1	1.40e-04	6	91	2	EFO_0800404
Disease	triacylglycerol 56:8 measurement	FADS1 ZPR1 NCAN	1.88e-04	36	91	3	EFO_0010435
Disease	X-24870 measurement	FADS1 ZPR1	1.96e-04	7	91	2	EFO_0022143
Disease	level of Phosphatidylcholine (17:0_18:2) in blood serum	FADS1 ZPR1	1.96e-04	7	91	2	OBA_2045086
Disease	1-palmitoyl-2-linoleoyl-GPC (16:0/18:2) measurement	FADS1 ZPR1	2.60e-04	8	91	2	EFO_0800610
Disease	1-palmitoyl-2-stearoyl-GPC (16:0/18:0) measurement	FADS1 ZPR1	2.60e-04	8	91	2	EFO_0800396
Disease	cholesteryl esters to total lipids in small LDL percentage	FADS1 ZPR1 NCAN	2.99e-04	42	91	3	EFO_0022255
Disease	1-stearoyl-2-arachidonoyl-GPE (18:0/20:4) measurement	FADS1 ZPR1	3.34e-04	9	91	2	EFO_0800403
Disease	linoleoyl-arachidonoyl-glycerol (18:2/20:4) [1] measurement	FADS1 NCAN	4.17e-04	10	91	2	EFO_0800499
Disease	1-stearoyl-2-oleoyl-GPI (18:0/18:1) measurement	FADS1 ZPR1	4.17e-04	10	91	2	EFO_0800469
Disease	Neuroblastoma	NTRK2 BARD1 GNAS	4.17e-04	47	91	3	C0027819
Disease	omega-3 polyunsaturated fatty acid measurement	FADS1 ZPR1 ZMIZ2 NCAN	4.97e-04	118	91	4	EFO_0010119
Disease	linoleoyl-arachidonoyl-glycerol (18:2/20:4) [2] measurement	FADS1 NCAN	6.08e-04	12	91	2	EFO_0800500
Disease	triacylglycerol 54:9 measurement	FADS1 ZPR1	6.08e-04	12	91	2	EFO_0010427
Disease	triacylglycerol 53:2 measurement	FADS1 ZPR1	6.08e-04	12	91	2	EFO_0021484
Disease	level of Phosphatidylinositol (16:0_18:1) in blood serum	FADS1 ZPR1	6.08e-04	12	91	2	OBA_2045152
Disease	level of Phosphatidylinositol (18:0_20:3) in blood serum	FADS1 ZPR1	6.08e-04	12	91	2	OBA_2045157
Disease	1-stearoyl-2-linoleoyl-GPI (18:0/18:2) measurement	FADS1 ZPR1	7.18e-04	13	91	2	EFO_0800413
Disease	level of Triacylglycerol (53:3) in blood serum	FADS1 ZPR1	9.62e-04	15	91	2	OBA_2045165
Disease	phosphatidate measurement	FADS1 ZPR1	9.62e-04	15	91	2	EFO_0020047
Disease	1-stearoyl-2-arachidonoyl-GPI (18:0/20:4) measurement	FADS1 ZPR1	1.10e-03	16	91	2	EFO_0800184
Disease	diacylglycerol 36:2 measurement	FADS1 ZPR1	1.10e-03	16	91	2	EFO_0010355
Disease	level of Phosphatidylcholine (18:0_18:2) in blood serum	FADS1 ZPR1	1.10e-03	16	91	2	OBA_2045090
Disease	Tactile Amnesia	POMC HRH3	1.24e-03	17	91	2	C0750906
Disease	Amnestic State	POMC HRH3	1.24e-03	17	91	2	C0750907
Disease	Dissociative Amnesia	POMC HRH3	1.24e-03	17	91	2	C0236795
Disease	Hysterical amnesia	POMC HRH3	1.24e-03	17	91	2	C0233750
Disease	Temporary Amnesia	POMC HRH3	1.24e-03	17	91	2	C0233796
Disease	Amnesia	POMC HRH3	1.24e-03	17	91	2	C0002622
Disease	Global Amnesia	POMC HRH3	1.24e-03	17	91	2	C0262497
Disease	renal cell carcinoma (is_implicated_in)	CSF1R C4A C4B	1.28e-03	69	91	3	DOID:4450 (is_implicated_in)
Disease	Manic Disorder	NTRK2 NCAN POMC	1.39e-03	71	91	3	C0024713
Disease	Lupus Erythematosus, Systemic	PCNX3 C4A C4B	1.39e-03	71	91	3	C0024141
Disease	triacylglycerol 56:3 measurement	FADS1 ZPR1	1.39e-03	18	91	2	EFO_0010430
Disease	level of Phosphatidylinositol (18:0_18:1) in blood serum	FADS1 ZPR1	1.39e-03	18	91	2	OBA_2045155
Disease	diacylglycerol 36:3 measurement	FADS1 ZPR1	1.39e-03	18	91	2	EFO_0020062
Disease	sodium-coupled monocarboxylate transporter 1 measurement	FADS1 ZPR1	1.55e-03	19	91	2	EFO_0802076
Disease	level of Phosphatidylcholine (16:0_18:2) in blood serum	FADS1 ZPR1	1.72e-03	20	91	2	OBA_2045071
Disease	Manic	NTRK2 NCAN POMC	1.83e-03	78	91	3	C0338831
Disease	Depression, Bipolar	NTRK2 NCAN POMC	1.89e-03	79	91	3	C0005587
Disease	level of Phosphatidylinositol (18:0_18:2) in blood serum	FADS1 ZPR1	1.90e-03	21	91	2	OBA_2045156
Disease	triacylglycerol 54:6 measurement	FADS1 ZPR1	2.09e-03	22	91	2	EFO_0010424
Disease	level of Phosphatidylinositol (18:0_20:4) in blood serum	FADS1 ZPR1	2.28e-03	23	91	2	OBA_2045158
Disease	West Syndrome	NTRK2 POMC	2.48e-03	24	91	2	C0037769
Disease	triacylglycerol 52:6 measurement	ZPR1 NCAN	2.69e-03	25	91	2	EFO_0010418
Disease	diacylglycerol 34:2 measurement	FADS1 ZPR1	2.69e-03	25	91	2	EFO_0010353
Disease	level of Sterol ester (27:1/18:2) in blood serum	FADS1 ZPR1	2.91e-03	26	91	2	OBA_2045194
Disease	level of Sterol ester (27:1/16:0) in blood serum	FADS1 NCAN	2.91e-03	26	91	2	OBA_2045191

Protein segments in the cluster

Peptide	Gene	Start	Entry
APGPEPAAAAVGSSM	ZNF385C	196	Q66K41
QPEVGASGPAMAEPH	AMER3	846	Q8N944
DAPLELGDSSPQGPM	ARHGEF1	341	Q92888
MPNVAPAAIHAAPGD	ELK1	111	P19419
SPMPLGTAQGDPGEA	ACTL7B	6	Q9Y614
SGNEPRSAPAMEPDG	BARD1	16	Q99728
PGNSDPNMIPDGDFN	C4B	961	P0C0L5
VDFADPQGPSLPGMD	AMBN	181	Q9NP70
PENEEGGAQGSPMPE	AMBN	316	Q9NP70
SDRDAASGPEAPMQP	ADO	31	Q96SZ5
ASGPEAPMQPGFPEN	ADO	36	Q96SZ5
TGAEAAPAAPPAKMA	BTBD6	41	Q96KE9
MAEAAEPEGVAPGPQ	CLIC6	1	Q96NY7
DMDGAPSSAVGPGLP	CACNA1B	2076	Q00975
NARGAPMDPTESPAA	CGAS	26	Q8N884
EMKPVAAGAAAPPGE	ASH2L	31	Q9UBL3
AAADPPPAMPQAAGA	SLC25A16	11	P16260
PGLSMFAGQAAQPDP	NTN1	26	O95631
MAAATADPGAGNPQP	RANBP10	1	Q6VN20
QGPSAEAHEGAPDPM	RAVER2	31	Q9HCJ3
PAPAGMASSQGGPAL	RFWD3	21	Q6PCD5
MHNPDGSASPTADPG	OCEL1	1	Q9H607
MGPEAAPAATHAAPQ	ZFYVE28	696	Q9HCC9
AMTAENPTPGDLAPA	RNF144B	11	Q7Z419
GEMQAPNAPGLPADV	MAGEE1	26	Q9HCI5
EVGPAAPAMAPAPAS	MAP7	421	Q14244
ADPSDPFESPVMAGG	GALNT10	306	Q86SR1
MPEPGPDAAGTASAQ	HMX3	1	A6NHT5
ASAPPEFLDPLMGAA	LMTK3	726	Q96Q04
AQGDSNPPRDPGVEM	PCNX3	106	Q9H6A9
AETPMFPGNGDEQPL	POMC	56	P01189
MGAAAAEGQAPDPSP	EHBP1L1	1306	Q8N3D4
ECAPAPGAPAHAEGM	LAMB2	291	P55268
SFPDEPSLAEMGPAN	LHX3	256	Q9UBR4
PPHAGEGEMAQPADS	GGN	221	Q86UU5
APEFEPHPMASNGGG	HOXD3	331	P31249
MAAPEPLSPAGGAGE	MPND	1	Q8N594
EDMGPSARGLPAAQP	NEURL2	211	Q9BR09
LAASGMAPGPFAGPQ	MED30	6	Q96HR3
PAQPMSPGEATQSGA	MYBBP1A	6	Q9BQG0
GPEARPASSAPGMQA	OSCAR	221	Q8IYS5
SFDLEPDSNPPGGMF	NRP1	191	O14786
AMLGPSLSPGQDPEG	CSF1R	681	P07333
PMVAPQSGDPDPGAS	IGLL5	41	B9A064
GDAMSPDFIPSQPEG	HAL	86	P42357
EEAGASPGMPGQPEQ	DMRT2	66	Q9Y5R5
AVAMPSLAGPPFGAE	DMRTB1	151	Q96MA1
SGNLDYNGAPPMAPS	HOXB3	381	P14651
EDLPPMGGPSNFAQN	BCL9L	641	Q86UU0
MGPNATAEEGAPSAA	ABCA2	376	Q9BZC7
CDDQRPMDGDSPSPG	APBA1	391	Q02410
MAPDPVAAETAAQGP	FADS1	1	O60427
MERAPPDGPLNASGA	HRH3	1	Q9Y5N1
GEAAAMIPPPQSSGN	C1orf159	191	Q96HA4
EASQMPPPAGGTSDD	SCNN1D	751	P51172
GPGVDVPAPDMNTGE	GLUD2	216	P49448
GSVGASGPLEPPAMN	DRP2	66	Q13474
PGNSDPNMIPDGDFN	C4A	961	P0C0L4
AAGAAFSPGEDDPGM	ARHGAP30	536	Q7Z6I6
SPGMAAEGDQLSLPP	RIN3	401	Q8TB24
MAESQGPESFGPQRP	MN1	156	Q10571
ADPSDPFESPVMAGG	GALNTL6	301	Q49A17
MDAPGALAQTAAPGP	RHOF	1	Q9HBH0
MNGAPSPEDGASPSS	SH2B1	1	Q9NRF2
PPAAFGGAECQGPTM	SSPOP	3016	A2VEC9
APPAPAAAAQEAMDG	NKX1-1	26	Q15270
MAAPPSPGRTADQAD	RNF113B	1	Q8IZP6
AAAPGAGPSPAEEME	GNAS	36	Q5JWF2
EEPALPGTPMNAGAE	NCAN	991	O14594
MATLPAEPSAGPAAG	SIX5	1	Q8N196
PLVAAAMEGPSNPGD	SHROOM4	736	Q9ULL8
AAAFRPMGPAGPAAQ	SMARCD2	56	Q92925
GDPFAAPQMAPAFAA	AGFG2	231	O95081
APAAAAGMAGVAAPP	CHST2	136	Q9Y4C5
AHGPDAVLMAEGNPP	NTRK2	631	Q16620
MSGADRSPNAGAAPD	PNMT	1	P11086
LPAAEAMATPSPAGG	TNRC18	1181	O15417
APSSPDDSSGMGPLN	ZNF750	501	Q32MQ0
MAAAAAAGPSPGSGP	VPS51	1	Q9UID3
DPPAQCSAGPVGDDM	UBE2D2	16	P62837
MEAAVAPGRDAPAPA	SCLY	1	Q96I15
MAASGAVEPGPPGAA	ZPR1	1	O75312
PPMASDAVPGQEGSD	ZSCAN32	346	Q9NX65
SEAEGSFLAPGMPDP	TIAM2	261	Q8IVF5
SPAADNPEMSGGGAP	SMTNL1	16	A8MU46
RAPPASGDGFEPQMV	TRAPPC12	166	Q8WVT3
ADAADAAGFPVPPDM	VCL	931	P18206
DPPAQCSAGPVGDDM	UBE2D3	16	P61077
PAGAEELSSAMANPP	ZDBF2	2276	Q9HCK1
GDGQPSLEPPMAAAF	PTBP3	281	O95758
PSMSGAGEAPEPALD	ZMIZ2	871	Q8NF64
MAAAAPNAGGSAPET	TIMM22	1	Q9Y584
DTPAGGEPLQADGMA	ZBTB49	696	Q6ZSB9
MSDSQGPPALGPEAA	WSCD1	121	Q658N2
PAPEDAPAQAAGEAG	PRRT1B	71	A0A1B0GWB2
PDAMFGQPGALGSTP	YTHDF2	101	Q9Y5A9
MPANEDAPQPGEHGS	ZNF81	1	P51508
APPPEGGMEQALAGA	ZNF263	346	O14978