Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	SCRT2 ZNF705A ZNF311 ZNF142 ZNF705EP ZNF507 SREBF2 SKOR1 ZBTB40 ZNF350 ZNF841 PPARA ZNF705B ADNP BATF2 ZNF705D ZNF461 ZNF705G	6.77e-05	1412	92	18	GO:0000981
GeneOntologyMolecularFunction	transition metal ion binding	CYP1A1 FBXO40 ZDHHC15 SLC11A2 L3MBTL1 KMT2B DYTN ADAMTS20 KDM7A TRIM68 PPARA ZCCHC7 PPM1K MDM2 ADNP ZNF512	9.77e-05	1189	92	16	GO:0046914
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	SCRT2 ZNF705A ZNF311 ZNF142 ZNF705EP ZNF507 SREBF2 SKOR1 ZNF350 ZNF841 PPARA ZNF705B ADNP BATF2 ZNF564 ZNF705D ZNF461 ZNF705G	1.03e-04	1459	92	18	GO:0000977
GeneOntologyMolecularFunction	zinc ion binding	FBXO40 ZDHHC15 SLC11A2 L3MBTL1 KMT2B DYTN ADAMTS20 KDM7A TRIM68 PPARA ZCCHC7 MDM2 ZNF512	2.17e-04	891	92	13	GO:0008270
GeneOntologyMolecularFunction	ubiquitin protein ligase activity	MKRN3 FBXO40 RNF181 MKRN1 CHFR TRIM68 MDM2 WDR24	3.21e-04	372	92	8	GO:0061630
GeneOntologyMolecularFunction	ubiquitin-protein transferase activity	MKRN3 FBXO40 RNF181 MKRN1 CHFR TRIM68 MDM2 BIRC6 WDR24	3.32e-04	473	92	9	GO:0004842
GeneOntologyMolecularFunction	ubiquitin-like protein ligase activity	MKRN3 FBXO40 RNF181 MKRN1 CHFR TRIM68 MDM2 WDR24	5.03e-04	398	92	8	GO:0061659
GeneOntologyMolecularFunction	ubiquitin-like protein transferase activity	MKRN3 FBXO40 RNF181 MKRN1 CHFR TRIM68 MDM2 BIRC6 WDR24	5.88e-04	512	92	9	GO:0019787
GeneOntologyMolecularFunction	aminoacyltransferase activity	MKRN3 FBXO40 RNF181 MKRN1 CHFR TRIM68 MDM2 BIRC6 WDR24	7.73e-04	532	92	9	GO:0016755
GeneOntologyMolecularFunction	acyltransferase activity	MKRN3 FBXO40 ZDHHC15 RNF181 MKRN1 CHFR TRIM68 MDM2 ELP3 BIRC6 WDR24	8.61e-04	775	92	11	GO:0016746
GeneOntologyBiologicalProcess	sensory processing	SHANK1 CHRFAM7A CHRNA7	7.98e-07	5	90	3	GO:0050893
GeneOntologyBiologicalProcess	behavioral response to nicotine	PPARA CHRFAM7A CHRNA7	1.29e-05	11	90	3	GO:0035095
GeneOntologyBiologicalProcess	positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure	CHRFAM7A CHRNA7	1.88e-05	2	90	2	GO:0001988
GeneOntologyBiologicalProcess	baroreceptor response to decreased systemic arterial blood pressure	CHRFAM7A CHRNA7	5.63e-05	3	90	2	GO:0001982
GeneOntologyBiologicalProcess	generation of ovulation cycle rhythm	CHRFAM7A CHRNA7	1.12e-04	4	90	2	GO:0060112
GeneOntologyBiologicalProcess	regulation of nervous system process	SHANK1 SREBF2 GRM1 CHRFAM7A CHRNA7 BEGAIN	1.18e-04	175	90	6	GO:0031644
GeneOntologyBiologicalProcess	response to food	CYP1A1 PPARA CHRFAM7A CHRNA7	1.20e-04	58	90	4	GO:0032094
GeneOntologyCellularComponent	spine apparatus membrane	CHRFAM7A CHRNA7	5.61e-05	3	91	2	GO:0098897
MousePheno	airway basal cell hyperplasia	CHRFAM7A CHRNA7	1.94e-05	2	62	2	MP:0011115
MousePheno	abnormal airway basal cell differentiation	CHRFAM7A CHRNA7	1.94e-05	2	62	2	MP:0011114
MousePheno	abnormal airway basal cell morphology	CHRFAM7A CHRNA7	1.94e-05	2	62	2	MP:0011113
MousePheno	abnormal nicotine-mediated receptor currents	CHRFAM7A CHRNA7	1.15e-04	4	62	2	MP:0009475
Domain	ZINC_FINGER_C2H2_2	SCRT2 ZNF705A ZNF311 ZNF142 ZNF507 ZBTB40 ZNF350 ZNF841 ZNF705B ADNP ZNF512 ZNF564 ZNF705D ZNF687 ZNF461 ZNF705G	6.87e-07	775	89	16	PS50157
Domain	ZINC_FINGER_C2H2_1	SCRT2 ZNF705A ZNF311 ZNF142 ZNF507 ZBTB40 ZNF350 ZNF841 ZNF705B ADNP ZNF512 ZNF564 ZNF705D ZNF687 ZNF461 ZNF705G	7.11e-07	777	89	16	PS00028
Domain	zf-C2H2	SCRT2 ZNF705A ZNF311 ZNF142 ZNF507 ZBTB40 ZNF350 ZNF841 ZNF705B ADNP ZNF512 ZNF564 ZNF705D ZNF687 ZNF461	8.91e-07	693	89	15	PF00096
Domain	Znf_C2H2/integrase_DNA-bd	SCRT2 ZNF705A ZNF311 ZNF142 ZNF507 ZBTB40 ZNF350 ZNF841 ZNF705B ADNP ZNF564 ZNF705D ZNF687 ZNF461 ZNF705G	9.07e-07	694	89	15	IPR013087
Domain	Znf_C2H2-like	SCRT2 ZNF705A ZNF311 ZNF142 ZNF507 ZBTB40 ZNF350 ZNF841 ZNF705B ADNP ZNF512 ZNF564 ZNF705D ZNF687 ZNF461 ZNF705G	9.77e-07	796	89	16	IPR015880
Domain	Znf_C2H2	SCRT2 ZNF705A ZNF311 ZNF142 ZNF507 ZBTB40 ZNF350 ZNF841 ZNF705B ADNP ZNF512 ZNF564 ZNF705D ZNF687 ZNF461 ZNF705G	1.13e-06	805	89	16	IPR007087
Domain	ZnF_C2H2	SCRT2 ZNF705A ZNF311 ZNF142 ZNF507 ZBTB40 ZNF350 ZNF841 ZNF705B ADNP ZNF512 ZNF564 ZNF705D ZNF687 ZNF461 ZNF705G	1.19e-06	808	89	16	SM00355
Domain	-	SCRT2 ZNF705A ZNF311 ZNF142 ZNF507 ZBTB40 ZNF350 ZNF841 ZNF705B ZNF564 ZNF705D ZNF461 ZNF705G	1.91e-05	679	89	13	3.30.160.60
Domain	MKRN1_C	MKRN3 MKRN1	2.25e-05	2	89	2	PF15815
Domain	MKRN1_C	MKRN3 MKRN1	2.25e-05	2	89	2	IPR031644
Domain	AT_hook	PDS5B KMT2B ASH1L	2.82e-04	27	89	3	SM00384
Domain	AT_hook_DNA-bd_motif	PDS5B KMT2B ASH1L	2.82e-04	27	89	3	IPR017956
Domain	-	MKRN3 KMT2B RNF181 MKRN1 ASH1L CHFR KDM7A TRIM68 MDM2	2.87e-04	449	89	9	3.30.40.10
Domain	KRAB	ZNF705A ZNF311 ZNF350 ZNF705B ZNF564 ZNF705D ZNF461 ZNF705G	3.08e-04	358	89	8	PS50805
Domain	KRAB	ZNF705A ZNF311 ZNF350 ZNF705B ZNF564 ZNF705D ZNF461 ZNF705G	3.08e-04	358	89	8	PF01352
Domain	Znf_RING/FYVE/PHD	MKRN3 KMT2B RNF181 MKRN1 ASH1L CHFR KDM7A TRIM68 MDM2	3.38e-04	459	89	9	IPR013083
Domain	KRAB	ZNF705A ZNF311 ZNF350 ZNF705B ZNF564 ZNF705D ZNF461 ZNF705G	3.78e-04	369	89	8	SM00349
Domain	KRAB	ZNF705A ZNF311 ZNF350 ZNF705B ZNF564 ZNF705D ZNF461 ZNF705G	3.84e-04	370	89	8	IPR001909
Domain	PTX	ADGRG4 SVEP1	9.86e-04	10	89	2	SM00159
Domain	Pentaxin-related	ADGRG4 SVEP1	1.20e-03	11	89	2	IPR001759
Domain	Pentaxin	ADGRG4 SVEP1	1.20e-03	11	89	2	PF00354
Domain	Post-SET_dom	KMT2B ASH1L	2.58e-03	16	89	2	IPR003616
Domain	PostSET	KMT2B ASH1L	2.58e-03	16	89	2	SM00508
Domain	POST_SET	KMT2B ASH1L	2.58e-03	16	89	2	PS50868
Domain	ZF_RING_1	MKRN3 RNF181 MKRN1 CHFR TRIM68 MDM2	2.68e-03	291	89	6	PS00518
Domain	ZF_RING_2	MKRN3 RNF181 MKRN1 CHFR TRIM68 MDM2	3.01e-03	298	89	6	PS50089
Domain	RING	MKRN3 RNF181 MKRN1 CHFR TRIM68 MDM2	3.38e-03	305	89	6	SM00184
Domain	zf-C3HC4	MKRN3 RNF181 MKRN1 CHFR TRIM68	4.27e-03	223	89	5	PF00097
Domain	Znf_RING	MKRN3 RNF181 MKRN1 CHFR TRIM68 MDM2	4.67e-03	326	89	6	IPR001841
Domain	ADAM_spacer1	ADAMTS18 ADAMTS20	5.32e-03	23	89	2	IPR010294
Domain	-	CHRFAM7A CHRNA7	5.32e-03	23	89	2	1.20.120.370
Domain	ADAM_spacer1	ADAMTS18 ADAMTS20	5.32e-03	23	89	2	PF05986
Domain	Acetylcholine_rcpt_TM	CHRFAM7A CHRNA7	5.32e-03	23	89	2	IPR027361
Pubmed	Nicotine regulates multiple synaptic proteins by inhibiting proteasomal activity.	SHANK1 CHRFAM7A CHRNA7	6.43e-07	7	93	3	17898222
Pubmed	Enhancing cognitive function in chronic TBI: The Role of α7 nicotinic acetylcholine receptor modulation.	CHRFAM7A CHRNA7	7.07e-06	2	93	2	38070724
Pubmed	Inflammatory cytokines decrease the expression of nicotinic acetylcholine receptor during the cell maturation.	CHRFAM7A CHRNA7	7.07e-06	2	93	2	19626424
Pubmed	Episodic memory performance predicted by the 2bp deletion in exon 6 of the "alpha 7-like" nicotinic receptor subunit gene.	CHRFAM7A CHRNA7	7.07e-06	2	93	2	17012698
Pubmed	Cholinergic Pathway Suppresses Pulmonary Innate Immunity Facilitating Pneumonia After Stroke.	CHRFAM7A CHRNA7	7.07e-06	2	93	2	26451017
Pubmed	Genetic deletion of α7 nicotinic acetylcholine receptors induces an age-dependent Alzheimer's disease-like pathology.	CHRFAM7A CHRNA7	7.07e-06	2	93	2	34453977
Pubmed	Perinatal hypoxia-ischemia reduces α 7 nicotinic receptor expression and selective α 7 nicotinic receptor stimulation suppresses inflammation and promotes microglial Mox phenotype.	CHRFAM7A CHRNA7	7.07e-06	2	93	2	24757672
Pubmed	Inhibition of pancreatic acinar mitochondrial thiamin pyrophosphate uptake by the cigarette smoke component 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.	CHRFAM7A CHRNA7	7.07e-06	2	93	2	26999808
Pubmed	Positive allosteric modulators of α7 nicotinic acetylcholine receptors affect neither the function of other ligand- and voltage-gated ion channels and acetylcholinesterase, nor β-amyloid content.	CHRFAM7A CHRNA7	7.07e-06	2	93	2	27129924
Pubmed	Neuroprotection afforded by nicotine against oxygen and glucose deprivation in hippocampal slices is lost in alpha7 nicotinic receptor knockout mice.	CHRFAM7A CHRNA7	7.07e-06	2	93	2	17291692
Pubmed	Sensorimotor gating and spatial learning in α7-nicotinic receptor knockout mice.	CHRFAM7A CHRNA7	7.07e-06	2	93	2	23521765
Pubmed	Effect of α7 nicotinic acetylcholine receptor activation on cardiac fibroblasts: a mechanism underlying RV fibrosis associated with cigarette smoke exposure.	CHRFAM7A CHRNA7	7.07e-06	2	93	2	28258105
Pubmed	The cholinergic anti-inflammatory system limits T cell infiltration into the neurodegenerative CNS, but cannot counteract complex CNS inflammation.	CHRFAM7A CHRNA7	7.07e-06	2	93	2	19344760
Pubmed	Loss of α7nAChR enhances endothelial-to-mesenchymal transition after myocardial infarction via NF-κB activation.	CHRFAM7A CHRNA7	7.07e-06	2	93	2	35926661
Pubmed	The alpha7 nicotinic receptor agonist 4OH-GTS-21 protects axotomized septohippocampal cholinergic neurons in wild type but not amyloid-overexpressing transgenic mice.	CHRFAM7A CHRNA7	7.07e-06	2	93	2	17640819
Pubmed	Contribution of α7 nicotinic receptor to airway epithelium dysfunction under nicotine exposure.	CHRFAM7A CHRNA7	7.07e-06	2	93	2	23431157
Pubmed	Bidirectional Regulation of Aggression in Mice by Hippocampal Alpha-7 Nicotinic Acetylcholine Receptors.	CHRFAM7A CHRNA7	7.07e-06	2	93	2	29114104
Pubmed	Autophagy is Involved in Neuroprotective Effect of Alpha7 Nicotinic Acetylcholine Receptor on Ischemic Stroke.	CHRFAM7A CHRNA7	7.07e-06	2	93	2	33995108
Pubmed	E-cigarette-induced pulmonary inflammation and dysregulated repair are mediated by nAChR α7 receptor: role of nAChR α7 in SARS-CoV-2 Covid-19 ACE2 receptor regulation.	CHRFAM7A CHRNA7	7.07e-06	2	93	2	32552811
Pubmed	Reduced CHRNA7 expression in C3H mice is associated with increases in hippocampal parvalbumin and glutamate decarboxylase-67 (GAD67) as well as altered levels of GABA(A) receptor subunits.	CHRFAM7A CHRNA7	7.07e-06	2	93	2	24836856
Pubmed	Modulation of the MAPKs pathways affects Aβ-induced cognitive deficits in Alzheimer's disease via activation of α7nAChR.	CHRFAM7A CHRNA7	7.07e-06	2	93	2	31904546
Pubmed	Studies of sperm from mutant mice suggesting that two neurotransmitter receptors are important to the zona pellucida-initiated acrosome reaction.	CHRFAM7A CHRNA7	7.07e-06	2	93	2	15948184
Pubmed	Alpha7 nicotinic acetylcholine receptor mediates chronic nicotine inhalation-induced cardiopulmonary dysfunction.	CHRFAM7A CHRNA7	7.07e-06	2	93	2	35678315
Pubmed	CYP1A1 induction in the colon by serum: involvement of the PPARα pathway and evidence for a new specific human PPREα site.	CYP1A1 PPARA	7.07e-06	2	93	2	21304969
Pubmed	Age-Associated Tooth Loss and Oral Microbial Dysbiosis in a Mouse Genetic Model of Chronic Nicotine Exposure.	CHRFAM7A CHRNA7	7.07e-06	2	93	2	33117372
Pubmed	Functional role of alpha7 nicotinic receptor in physiological control of cutaneous homeostasis.	CHRFAM7A CHRNA7	7.07e-06	2	93	2	12628457
Pubmed	Activation of α-7 nicotinic acetylcholine receptor reduces ischemic stroke injury through reduction of pro-inflammatory macrophages and oxidative stress.	CHRFAM7A CHRNA7	7.07e-06	2	93	2	25157794
Pubmed	Selective alpha7 nicotinic receptor activation by AZD0328 enhances cortical dopamine release and improves learning and attentional processes.	CHRFAM7A CHRNA7	7.07e-06	2	93	2	19615981
Pubmed	Splenic nerve denervation attenuates depression-like behaviors in Chrna7 knock-out mice via the spleen-gut-brain axis.	CHRFAM7A CHRNA7	7.07e-06	2	93	2	38944290
Pubmed	Nicotine withdrawal-induced inattention is absent in alpha7 nAChR knockout mice.	CHRFAM7A CHRNA7	7.07e-06	2	93	2	28243714
Pubmed	Mesenchymal Stem Cells or Interleukin-6 Improve Episodic Memory of Mice Lacking α7 Nicotinic Acetylcholine Receptors.	CHRFAM7A CHRNA7	7.07e-06	2	93	2	31202708
Pubmed	Prenatal nicotine exposure alters lung function and airway geometry through α7 nicotinic receptors.	CHRFAM7A CHRNA7	7.07e-06	2	93	2	22246862
Pubmed	Stimulation of the α7 nicotinic acetylcholine receptor protects against sepsis by inhibiting Toll-like receptor via phosphoinositide 3-kinase activation.	CHRFAM7A CHRNA7	7.07e-06	2	93	2	24298024
Pubmed	Lung eosinophilia induced by house dust mites or ovalbumin is modulated by nicotinic receptor α7 and inhibited by cigarette smoke.	CHRFAM7A CHRNA7	7.07e-06	2	93	2	29975102
Pubmed	α7-nAChR Knockout Mice Decreases Biliary Hyperplasia and Liver Fibrosis in Cholestatic Bile Duct-Ligated Mice.	CHRFAM7A CHRNA7	7.07e-06	2	93	2	29580318
Pubmed	Alpha-7 Nicotinic Receptor Dampens Murine Osteoblastic Response to Inflammation and Age-Related Osteoarthritis.	CHRFAM7A CHRNA7	7.07e-06	2	93	2	35479080
Pubmed	[Activation of α7 nAChR improves white fat homeostasis and promotes beige adipogenesis and thermogenesis in obese mice].	CHRFAM7A CHRNA7	7.07e-06	2	93	2	38597441
Pubmed	Activation of Nicotinic Acetylcholine Receptors Decreases Apoptosis in Human and Female Murine Pancreatic Islets.	CHRFAM7A CHRNA7	7.07e-06	2	93	2	27471776
Pubmed	Targeting α-7 nicotinic acetylcholine receptor in the enteric nervous system: a cholinergic agonist prevents gut barrier failure after severe burn injury.	CHRFAM7A CHRNA7	7.07e-06	2	93	2	22688057
Pubmed	α7 Nicotinic acetylcholine receptor agonist attenuates neuropathological changes associated with intracerebral hemorrhage in mice.	CHRFAM7A CHRNA7	7.07e-06	2	93	2	22820264
Pubmed	Stimulation of α7-nAChRs coordinates autophagy and apoptosis signaling in experimental knee osteoarthritis.	CHRFAM7A CHRNA7	7.07e-06	2	93	2	33953172
Pubmed	Different Effects of Nicotine and N-Stearoyl-ethanolamine on Episodic Memory and Brain Mitochondria of α7 Nicotinic Acetylcholine Receptor Knockout Mice.	CHRFAM7A CHRNA7	7.07e-06	2	93	2	32028688
Pubmed	Genetic variation in CHRNA7 and CHRFAM7A is associated with nicotine dependence and response to varenicline treatment.	CHRFAM7A CHRNA7	7.07e-06	2	93	2	30089821
Pubmed	Nicotinic acetylcholine receptor activation reduces skeletal muscle inflammation of mdx mice.	CHRFAM7A CHRNA7	7.07e-06	2	93	2	20615555
Pubmed	Nicotine physical dependence in the mouse: involvement of the alpha7 nicotinic receptor subtype.	CHRFAM7A CHRNA7	7.07e-06	2	93	2	15896732
Pubmed	Activation of α7 Nicotinic Acetylcholine Receptor Ameliorates Zymosan-Induced Acute Kidney Injury in BALB/c Mice.	CHRFAM7A CHRNA7	7.07e-06	2	93	2	30429582
Pubmed	A transgenic mouse model reveals fast nicotinic transmission in hippocampal pyramidal neurons.	CHRFAM7A CHRNA7	7.07e-06	2	93	2	21501254
Pubmed	α7-cholinergic receptor mediates vagal induction of splenic norepinephrine.	CHRFAM7A CHRNA7	7.07e-06	2	93	2	21339364
Pubmed	Cardiopulmonary arrest and resuscitation disrupts cholinergic anti-inflammatory processes: a role for cholinergic α7 nicotinic receptors.	CHRFAM7A CHRNA7	7.07e-06	2	93	2	21368056
Pubmed	Genetic variation within the Chrna7 gene modulates nicotine reward-like phenotypes in mice.	CHRFAM7A CHRNA7	7.07e-06	2	93	2	24289814
Pubmed	Requisite role of the cholinergic alpha7 nicotinic acetylcholine receptor pathway in suppressing Gram-negative sepsis-induced acute lung inflammatory injury.	CHRFAM7A CHRNA7	7.07e-06	2	93	2	19949071
Pubmed	Expression of human apolipoprotein A-II and its effect on high density lipoproteins in transgenic mice.	CHRFAM7A CHRNA7	7.07e-06	2	93	2	1400473
Pubmed	Reversible inhibition of GABAA receptors by alpha7-containing nicotinic receptors on the vertebrate postsynaptic neurons.	CHRFAM7A CHRNA7	7.07e-06	2	93	2	17204496
Pubmed	Activation of Alpha 7 Cholinergic Nicotinic Receptors Reduce Blood-Brain Barrier Permeability following Experimental Traumatic Brain Injury.	CHRFAM7A CHRNA7	7.07e-06	2	93	2	26937017
Pubmed	α7 nicotinic receptors play a role in regulation of cardiac hemodynamics.	CHRFAM7A CHRNA7	7.07e-06	2	93	2	37017608
Pubmed	Impaired hippocampal theta oscillations in the mice null alpha7 nicotinic acetylcholine receptors.	CHRFAM7A CHRNA7	7.07e-06	2	93	2	23795917
Pubmed	Diminished α7 nicotinic acetylcholine receptor (α7nAChR) rescues amyloid-β induced atrial remodeling by oxi-CaMKII/MAPK/AP-1 axis-mediated mitochondrial oxidative stress.	CHRFAM7A CHRNA7	7.07e-06	2	93	2	36603528
Pubmed	Endogenous signaling through alpha7-containing nicotinic receptors promotes maturation and integration of adult-born neurons in the hippocampus.	CHRFAM7A CHRNA7	7.07e-06	2	93	2	20592195
Pubmed	Activation of α7nAChR Promotes Diabetic Wound Healing by Suppressing AGE-Induced TNF-α Production.	CHRFAM7A CHRNA7	7.07e-06	2	93	2	26650489
Pubmed	Increased sensitivity to nicotine-induced seizures in mice expressing the L250T alpha 7 nicotinic acetylcholine receptor mutation.	CHRFAM7A CHRNA7	7.07e-06	2	93	2	11854451
Pubmed	Lack of modulation of nicotinic acetylcholine alpha-7 receptor currents by kynurenic acid in adult hippocampal interneurons.	CHRFAM7A CHRNA7	7.07e-06	2	93	2	22848433
Pubmed	Nicotine prevents synaptic impairment induced by amyloid-β oligomers through α7-nicotinic acetylcholine receptor activation.	CHRFAM7A CHRNA7	7.07e-06	2	93	2	23842742
Pubmed	Abeta(1-42) modulation of Akt phosphorylation via alpha7 nAChR and NMDA receptors.	CHRFAM7A CHRNA7	7.07e-06	2	93	2	17292512
Pubmed	Impaired attention is central to the cognitive deficits observed in alpha 7 deficient mice.	CHRFAM7A CHRNA7	7.07e-06	2	93	2	16650968
Pubmed	Microglial cell response in α7 nicotinic acetylcholine receptor-deficient mice after systemic infection with Escherichia coli.	CHRFAM7A CHRNA7	7.07e-06	2	93	2	35413868
Pubmed	Circulating brain microvascular endothelial cells (cBMECs) as potential biomarkers of the blood-brain barrier disorders caused by microbial and non-microbial factors.	CHRFAM7A CHRNA7	7.07e-06	2	93	2	23637989
Pubmed	Genomic organization and partial duplication of the human alpha7 neuronal nicotinic acetylcholine receptor gene (CHRNA7).	CHRFAM7A CHRNA7	7.07e-06	2	93	2	9782083
Pubmed	Long-term improvements in sensory inhibition with gestational choline supplementation linked to α7 nicotinic receptors through studies in Chrna7 null mutation mice.	CHRFAM7A CHRNA7	7.07e-06	2	93	2	24462939
Pubmed	Probing the putative α7 nAChR/NMDAR complex in human and murine cortex and hippocampus: Different degrees of complex formation in healthy and Alzheimer brain tissue.	CHRFAM7A CHRNA7	7.07e-06	2	93	2	29261717
Pubmed	Altered hippocampal circuit function in C3H alpha7 null mutant heterozygous mice.	CHRFAM7A CHRNA7	7.07e-06	2	93	2	18199426
Pubmed	Stroke-induced activation of the α7 nicotinic receptor increases Pseudomonas aeruginosa lung injury.	CHRFAM7A CHRNA7	7.07e-06	2	93	2	22490926
Pubmed	Kynurenic acid blunts A1 astrocyte activation against neurodegeneration in HIV-associated neurocognitive disorders.	CHRFAM7A CHRNA7	7.07e-06	2	93	2	36997969
Pubmed	A phenotype for the alpha 7 nicotinic acetylcholine receptor null mutant.	CHRFAM7A CHRNA7	7.07e-06	2	93	2	15364017
Pubmed	Choline, an alpha7 nicotinic acetylcholine receptor agonist, alleviates hyperalgesia in a rat osteoarthritis model.	CHRFAM7A CHRNA7	7.07e-06	2	93	2	23769729
Pubmed	Mice deficient in CHRNA7, a subunit of the nicotinic acetylcholine receptor, produce sperm with impaired motility.	CHRFAM7A CHRNA7	7.07e-06	2	93	2	15944242
Pubmed	Dendritic spine alterations in the hippocampus and parietal cortex of alpha7 nicotinic acetylcholine receptor knockout mice.	CHRFAM7A CHRNA7	7.07e-06	2	93	2	23270857
Pubmed	Neuronal nicotinic alpha7 receptors modulate inflammatory cytokine production in the skin following ultraviolet radiation.	CHRFAM7A CHRNA7	7.07e-06	2	93	2	18077004
Pubmed	Smoking in adult attention-deficit/hyperactivity disorder: interaction between 15q13 nicotinic genes and Temperament Character Inventory scores.	CHRFAM7A CHRNA7	7.07e-06	2	93	2	19462340
Pubmed	Evidence for a new human CYP1A1 regulation pathway involving PPAR-alpha and 2 PPRE sites.	CYP1A1 PPARA	7.07e-06	2	93	2	15521013
Pubmed	Performance deficit of alpha7 nicotinic receptor knockout mice in a delayed matching-to-place task suggests a mild impairment of working/episodic-like memory.	CHRFAM7A CHRNA7	7.07e-06	2	93	2	16923147
Pubmed	NMR structural analysis of alpha-bungarotoxin and its complex with the principal alpha-neurotoxin-binding sequence on the alpha 7 subunit of a neuronal nicotinic acetylcholine receptor.	CHRFAM7A CHRNA7	7.07e-06	2	93	2	11790782
Pubmed	A role of the subdiaphragmatic vagus nerve in depression-like phenotypes in mice after fecal microbiota transplantation from Chrna7 knock-out mice with depression-like phenotypes.	CHRFAM7A CHRNA7	7.07e-06	2	93	2	33422641
Pubmed	Nicotinic ACh receptor α7 inhibits PDGF-induced migration of vascular smooth muscle cells by activating mitochondrial deacetylase sirtuin 3.	CHRFAM7A CHRNA7	7.07e-06	2	93	2	30270436
Pubmed	Activation of α-7 Nicotinic Acetylcholine Receptor Attenuates Cardiac Inflammation Through NLRP3/Caspase-1/IL-18 Pathway.	CHRFAM7A CHRNA7	7.07e-06	2	93	2	34988776
Pubmed	Genetic deletion of α7 nAChRs reduces hippocampal granule and pyramidal cell number in both sexes but impairs pattern separation in males only.	CHRFAM7A CHRNA7	7.07e-06	2	93	2	37746145
Pubmed	A 2-base pair deletion polymorphism in the partial duplication of the alpha7 nicotinic acetylcholine gene (CHRFAM7A) on chromosome 15q14 is associated with schizophrenia.	CHRFAM7A CHRNA7	7.07e-06	2	93	2	19631623
Pubmed	Deletion of the alpha7 nicotinic receptor subunit gene results in increased sensitivity to several behavioral effects produced by alcohol.	CHRFAM7A CHRNA7	7.07e-06	2	93	2	15770102
Pubmed	Downregulation of mGluR1-mediated signaling underlying autistic-like core symptoms in Shank1 P1812L-knock-in mice.	SHANK1 GRM1	7.07e-06	2	93	2	37880287
Pubmed	Cortical synaptic NMDA receptor deficits in α7 nicotinic acetylcholine receptor gene deletion models: implications for neuropsychiatric diseases.	CHRFAM7A CHRNA7	7.07e-06	2	93	2	24326163
Pubmed	Loss of α7 nicotinic acetylcholine receptors in GABAergic neurons causes sex-dependent decreases in radial glia-like cell quantity and impairments in cognitive and social behavior.	CHRFAM7A CHRNA7	7.07e-06	2	93	2	33398432
Pubmed	Functional role of alpha7 nicotinic receptor in chronic neuropathic and inflammatory pain: studies in transgenic mice.	CHRFAM7A CHRNA7	7.07e-06	2	93	2	23811428
Pubmed	beta-Amyloid activates presynaptic alpha7 nicotinic acetylcholine receptors reconstituted into a model nerve cell system: involvement of lipid rafts.	CHRFAM7A CHRNA7	7.07e-06	2	93	2	20374280
Pubmed	Proteome profile of the cerebellum from α7 nicotinic acetylcholine receptor deficient mice.	CHRFAM7A CHRNA7	7.07e-06	2	93	2	38185761
Pubmed	Alpha 7 subunit of nAChR regulates migration of human mesenchymal stem cells.	CHRFAM7A CHRNA7	7.07e-06	2	93	2	20720594
Pubmed	α7 nicotinic acetylcholine receptor-mediated neuroprotection against dopaminergic neuron loss in an MPTP mouse model via inhibition of astrocyte activation.	CHRFAM7A CHRNA7	7.07e-06	2	93	2	22624500
Pubmed	Involvement of acetylcholine-α7nAChR in the protective effects of arterial baroreflex against ischemic stroke.	CHRFAM7A CHRNA7	7.07e-06	2	93	2	23106973
Pubmed	Suppression of neuroinflammation by an allosteric agonist and positive allosteric modulator of the α7 nicotinic acetylcholine receptor GAT107.	CHRFAM7A CHRNA7	7.07e-06	2	93	2	33902624
Pubmed	Impaired performance of alpha7 nicotinic receptor knockout mice in the five-choice serial reaction time task.	CHRFAM7A CHRNA7	7.07e-06	2	93	2	17019565
Pubmed	Dilinoleoylphosphatidylcholine ameliorates scopolamine-induced impairment of spatial learning and memory by targeting alpha7 nicotinic ACh receptors.	CHRFAM7A CHRNA7	7.07e-06	2	93	2	19100751
Pubmed	Identification of an alternatively processed nicotinic receptor alpha7 subunit RNA in mouse brain.	CHRFAM7A CHRNA7	7.07e-06	2	93	2	14499477
Cytoband	9q33.2	OR1L6 PAPPA-AS1 OR1L4	6.98e-05	39	93	3	9q33.2
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	SCRT2 ZNF705A ZNF311 ZNF142 ZNF507 ZBTB40 ZNF350 ZNF841 ZNF705B ZNF512 ZNF564 ZNF705D ZNF461 ZNF705G	4.36e-07	718	69	14	28
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L5_PT-L5_PT_ALM_Slco2a1\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	IVNS1ABP FRAS1 KLHL1 TAFA1 ADAMTS18	8.37e-06	133	92	5	9d7a08170d38ae9b2ff10a0fa505aeb3aae2824d
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L5_PT\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	IVNS1ABP FRAS1 KLHL1 TAFA1 ADAMTS18	8.69e-06	134	92	5	cb676d5bbc468bd3ce1b6712d41c986ee9221ac5
ToppCell	Cerebellum-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)\|Cerebellum / BrainAtlas - Mouse McCarroll V32	SHANK1 SCRT2 SKOR1 GRM1 ADNP	2.51e-05	167	92	5	9efb9511a211d0824bb97f82c1a5860c43d2138f
ToppCell	Cerebellum-Neuronal-Inhibitory\|Cerebellum / BrainAtlas - Mouse McCarroll V32	SHANK1 SCRT2 SKOR1 GRM1 ADNP	2.51e-05	167	92	5	904c613aac3f9919a432b110bb1dcc832b5aec0a
ToppCell	368C-Lymphocytic-ILC\|368C / Donor, Lineage, Cell class and subclass (all cells)	PDS5B EML4 TAFA1 RNF32-DT ZNF461	2.82e-05	171	92	5	3b3143e4aa6520ee9c6b6f2482206ad3d8205d14
ToppCell	facs\|World / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KMT2B NCKAP1 SREBF2 ECM1 BIRC6	2.82e-05	171	92	5	5bcb96ed7fc15548f2dc9cf47482f890640cb39c
ToppCell	facs\|World / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	KMT2B NCKAP1 SREBF2 ECM1 BIRC6	2.82e-05	171	92	5	bb71e816dde44fda6af0ad98d979be9f8740fda6
ToppCell	368C-Lymphocytic-ILC-ILC-2\|368C / Donor, Lineage, Cell class and subclass (all cells)	PDS5B EML4 TAFA1 RNF32-DT ZNF461	2.82e-05	171	92	5	fd01076574dcc82bfd4a1538812500543b16794f
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_PAX6-Inh_L1_PAX6_CA4\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ZNF311 WFDC5 CHRFAM7A SVEP1 CHRNA7	2.90e-05	172	92	5	0f2771e1e24fd2235ceb96663f0513b4dd6552d1
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1-6_VIP_RCN1\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ADAMTS18 WFDC5 CHRFAM7A STAC CHRNA7	4.10e-05	185	92	5	538db481c82b02e5d3b8e03b166f754cc936901e
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	IVNS1ABP TBC1D4 PPM1K GRM1 SYT13	4.89e-05	192	92	5	ee27d27e3d269764dbe8711d0b37ff9331a298a9
ToppCell	human_hepatoblastoma\|World / Sample and Cell Type and Tumor Cluster (all cells)	FRAS1 XRN2 EML4 ADAMTS18 PPP6R3	5.01e-05	193	92	5	e6a688bc834f845ff64dae1be64f073eec5091a1
ToppCell	Tracheal-10x3prime_v2-Stromal-Myofibroblastic-Muscle_smooth_airway_ASM\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	FBXO40 ZDHHC15 FRS3 LRP1B STAC	5.66e-05	198	92	5	cbb63b255bdc92a557c5db1f08f7766ed9346607
Disease	lung cancer (is_implicated_in)	CYP1A1 XRN2 LRP1B CHRNA7	6.33e-05	74	85	4	DOID:1324 (is_implicated_in)
Disease	cognitive disorder (implicated_via_orthology)	CHRFAM7A CHRNA7	1.22e-04	6	85	2	DOID:1561 (implicated_via_orthology)
Disease	rheumatoid arthritis (biomarker_via_orthology)	CHRFAM7A CHRNA7	1.22e-04	6	85	2	DOID:7148 (biomarker_via_orthology)
Disease	sarcoma (is_implicated_in)	SREBF2 MDM2	2.27e-04	8	85	2	DOID:1115 (is_implicated_in)
Disease	nicotine dependence (implicated_via_orthology)	CHRFAM7A CHRNA7	5.31e-04	12	85	2	DOID:0050742 (implicated_via_orthology)
Disease	gallbladder cancer (is_implicated_in)	CYP1A1 LRP1B	6.27e-04	13	85	2	DOID:3121 (is_implicated_in)
Disease	chronic obstructive pulmonary disease (is_implicated_in)	CYP1A1 LRP1B CHRNA7	8.09e-04	63	85	3	DOID:3083 (is_implicated_in)
Disease	1,3,7-trimethylurate measurement	CYP1A1 FRAS1	8.40e-04	15	85	2	EFO_0021172
Disease	Schizophrenia	SHANK1 SREBF2 PPARA GRM1 ADNP CHRFAM7A CHRNA7 GFRA3 SLC23A3	9.98e-04	883	85	9	C0036341
Disease	schizophrenia (implicated_via_orthology)	PPARA CHRFAM7A CHRNA7	1.01e-03	68	85	3	DOID:5419 (implicated_via_orthology)
Disease	chronic myeloid leukemia (is_implicated_in)	CYP1A1 MDM2	1.66e-03	21	85	2	DOID:8552 (is_implicated_in)
Disease	bone density, lean body mass	ZBTB40 PPP6R3	1.66e-03	21	85	2	EFO_0003923, EFO_0004995
Disease	hepatocellular carcinoma (is_implicated_in)	KMT2B PPARA MDM2 LRP1B	1.88e-03	181	85	4	DOID:684 (is_implicated_in)
Disease	response to clopidogrel, cardiovascular event measurement	CER1 PPM1K	1.99e-03	23	85	2	EFO_0006919, GO_1903493
Disease	Neurodevelopmental Disorders	NCKAP1 ASH1L ADNP	2.48e-03	93	85	3	C1535926

Protein segments in the cluster

Peptide	Gene	Start	Entry
LALCGVTCLCRHMHP	SYT13	21	Q7L8C5
HMLIHGLSCPYCRST	ADNP	506	Q9H2P0
LEGCSHPVVMKGLCA	CTDP1	111	Q9Y5B0
CHMSCPHLSPSKSLI	ASH1L	1536	Q9NR48
AVDSLLCSMCHVHPN	BIRC6	3541	Q9NR09
LHMEKHGCSLPSPLC	BEGAIN	156	Q9BUH8
CQCDHLTHFGVLMDL	ADGRG4	2716	Q8IZF6
CSHCLPAKFTTMHLP	CER1	206	O95813
CHRVGHRCETKFMPA	ADAMTS18	546	Q8TE60
SVIQCHMHACPADVS	ADAMTS20	1406	P59510
VCGRMACSPTHDEHL	CHRNA7	406	P36544
RMLANHALSTPHCAC	RNF32-DT	11	Q8NI28
LECVKFASHCLMNHP	PDS5B	331	Q9NTI5
GPAAADFCHTHMEKC	PPM1K	131	Q8N3J5
ICGHLCQKHLDMFLS	PAPPA-AS1	46	Q5QFB9
TPIYGLTMKHACCEH	CYP1A1	491	P04798
HGTLKPLHCACMVSD	ASB8	51	Q9H765
SGLEHSCPMPHLACS	MBD3L1	111	Q8WWY6
CEHMGLAHLSCASIK	OR52E2	181	Q8NGJ4
HCPNCAVLHGSSLMK	KDM7A	81	Q6ZMT4
HSSCLACMGPAPSHC	FRAS1	656	Q86XX4
HLCLLAPGKTHTCAC	LRP1B	3286	Q9NZR2
HEMLAHRAVLACCSP	IVNS1ABP	41	Q9Y6Y0
KMCLNPHCLALHSFI	HMGXB3	786	Q12766
KFTAHHCLSGCPLAE	L3MBTL1	636	Q9Y468
CLHPDLMKVACGDIH	OR51I1	181	Q9H343
HCFLLRTGMVHCLSE	PDE1B	236	Q01064
PLAVGCLTKCSHAFH	PMS2P11	21	Q13670
IALGMSFLDCGHTCH	SLC11A2	531	P49281
PMVCLLCASKGLHEL	KMT2B	1201	Q9UMN6
VCGRMACSPTHDEHL	CHRFAM7A	316	Q494W8
LLCTHFMSCTHELCP	NCKAP1	571	Q9Y2A7
TLRSKMGKCCHHCFP	POTEB3	56	A0JP26
IHPMSCFSIHKTRCA	OXGR1	136	Q96P68
MCVVCSHHSQISPIL	SCYL3	441	Q8IZE3
CALDIKHHCAAITPG	GLG1	1071	Q92896
LHDCVSLQPCMHTFC	CHFR	311	Q96EP1
HCHPMDILGTCATEQ	GFRA3	271	O60609
ICQMCFLSGLHSKSH	DYTN	251	A2CJ06
RHMVKCQGLCPSLHD	FRS3	251	O43559
TLHVHERLCPMDCAS	BATF2	76	Q8N1L9
AVMCKPHRCPHISFT	ELP3	91	Q9H9T3
ISCHLLCGATFHMCK	FBXO40	36	Q9UH90
FHMCKEAEHQLLCPL	FBXO40	46	Q9UH90
TLMHQIPCHSGIVCD	NSMAF	796	Q92636
ACSRAHMECPPAHTC	CRIPAK	311	Q8N1N5
LCPHCVSLQTGSHMD	IL25	111	Q9H293
KHIPGLIHNMTARCC	ECM1	436	Q16610
LGHTDCVKCLAIHPD	EML4	306	Q9HC35
NMHHALCPGHVGLCD	GRM1	426	Q13255
CLAARKAQAMCTGHH	GJB5	216	O95377
MECLCAHPPAGLQHL	LRRC43	186	Q8N309
CRFHKCLSVGMSHNA	PPARA	156	Q07869
LHGDSCDMCGLQVLH	MKRN1	231	Q9UHC7
HCLLMLLGSCSISHL	OR1L4	141	Q8NGR5
RHCLLMLLGSCSISH	OR1L6	176	Q8NGR2
SACAMLLCHGSLQHT	TAFA1	16	Q7Z5A9
HHFSCKMLTPRHCTG	SKOR1	941	P84550
MRAAGVGLVDCHCHL	TATDN3	1	Q17R31
MRSHTGEKPFGCAHC	SCRT2	231	Q9NQ03
EMPCHHLFHSSCILP	RNF181	91	Q9P0P0
PLGHCHRCSEPMFTI	LRRC28	311	Q86X40
VHGKTGHLMACFTCA	MDM2	451	Q00987
FPHCEHTSCGSLPMI	SVEP1	3056	Q4LDE5
SLMLHLCRGPSCHGL	SLC23A3	141	Q6PIS1
DGMTALHKAACARHC	SHANK1	246	Q9Y566
MPSHCLVHLHKNCIP	PPOX	406	P50336
RPCECSLCGKVFMHH	ZNF564	101	Q8TBZ8
LRCLSPMNHLCHKDS	WFDC5	86	Q8TCV5
PMSIDCGHSFCHSCL	TRIM68	26	Q6AZZ1
KMTHTGERPYACHLC	ZNF705A	191	Q6ZN79
LHGDICDMCGLQTLH	MKRN3	261	Q13064
IHHKCTDGLAPQRCM	STAC	146	Q99469
FHACRAMHASLPGKA	SREBF2	921	Q12772
HHCLCGADADLIMLG	XRN2	226	Q9H0D6
KMTHTGERPYTCHLC	ZNF705EP	191	A8MWA4
KMTHTGERPYACHLC	ZNF705G	191	A8MUZ8
KLCEACPMHSLHKLC	TBC1D4	451	O60343
CPMHSLHKLCERIEG	TBC1D4	456	O60343
VMHTGEKPHRCSLCE	ZNF350	226	Q9GZX5
SVHMRCHTGEKPLHC	ZNF841	441	Q6ZN19
KMTHTGERPYACHLC	ZNF705B	191	P0CI00
KMTHTGERPYACHLC	ZNF705D	191	P0CH99
CGYVCSHPPSLKSHM	ZNF507	791	Q8TCN5
ASHMHLKCKCHGLSG	WNT3A	196	P56704
CPVPKMLDHSCLFRH	ZCCHC7	286	Q8N3Z6
SHCEVFHKCPICPMA	ZNF687	786	Q8N1G0
VECRHHSCPMLFATA	ZNF142	316	P52746
MHCHLDAPANAISVC	WDR24	21	Q96S15
SMCAVCHHVVKGLFV	WDR24	741	Q96S15
HIEICPPGMSHSACS	PPP6R3	286	Q5H9R7
MFTCHHCGKQLRSLA	ZNF512	196	Q96ME7
RIHTGEKPHECMICG	ZNF461	461	Q8TAF7
RLHTGDRPFMCKHCL	ZBTB40	856	Q9NUA8
LIKPDRCHHCSVCAM	ZDHHC15	136	Q96MV8
KCEVCGMAFHHSSVL	ZNF311	556	Q5JNZ3
CCHFLMKLLHPSNCL	KLHL1	301	Q9NR64