Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	benzodiazepine receptor binding	RIMBP3 RIMBP3C RIMBP3B	6.88e-07	5	83	3	GO:0030156
GeneOntologyCellularComponent	Cul2-RING ubiquitin ligase complex	PRAMEF7 KLHDC3 PRAMEF12 PRAMEF8	2.69e-05	47	77	4	GO:0031462
GeneOntologyCellularComponent	manchette	RIMBP3 RIMBP3C RIMBP3B	1.47e-04	28	77	3	GO:0002177
MousePheno	abnormal large intestine morphology	PCSK5 PRAMEF7 IL17RE SRPK3 PRAMEF12 PRKDC PRAMEF8 KLRB1	1.93e-05	276	59	8	MP:0000489
MousePheno	abnormal cecum morphology	PRAMEF7 SRPK3 PRAMEF12 PRAMEF8 KLRB1	5.95e-05	99	59	5	MP:0000494
MousePheno	ectopic manchette	RIMBP3 RIMBP3C RIMBP3B	6.60e-05	19	59	3	MP:0009377
MousePheno	abnormal intestine morphology	PCSK5 PRAMEF7 IL17RE MAP3K14 SRPK3 PRAMEF12 PRKDC PRAMEF8 CTSD KLRB1	8.51e-05	546	59	10	MP:0000477
MousePheno	detached sperm flagellum	RIMBP3 RIMBP3C RIMBP3B	9.00e-05	21	59	3	MP:0008893
MousePheno	thymus cyst	MAP3K14 PRKDC	1.05e-04	4	59	2	MP:0014130
Domain	SCAN_BOX	ZNF24 ZSCAN31 ZKSCAN1 ZSCAN5DP PGBD1 ZNF396	1.49e-07	58	78	6	PS50804
Domain	SCAN	ZNF24 ZSCAN31 ZKSCAN1 ZSCAN5DP PGBD1 ZNF396	1.49e-07	58	78	6	PF02023
Domain	SCAN_dom	ZNF24 ZSCAN31 ZKSCAN1 ZSCAN5DP PGBD1 ZNF396	1.49e-07	58	78	6	IPR003309
Domain	Retrov_capsid_C	ZNF24 ZSCAN31 ZKSCAN1 ZSCAN5DP PGBD1 ZNF396	1.65e-07	59	78	6	IPR008916
Domain	PRAME_family	PRAMEF7 PRAMEF25 PRAMEF12 PRAMEF8	1.04e-06	19	78	4	IPR026271
Domain	SCAN	ZNF24 ZSCAN31 ZKSCAN1 PGBD1 ZNF396	3.61e-06	56	78	5	SM00431
Domain	SH3_2	RIMBP3 MPP4 ZDHHC6 RIMBP3C RIMBP3B	2.98e-05	86	78	5	IPR011511
Domain	SH3_2	RIMBP3 MPP4 ZDHHC6 RIMBP3C RIMBP3B	2.98e-05	86	78	5	PF07653
Domain	-	GTF3C2 DCAF10 PRPF4 WDR87 NBEA HERC1 BIRC6 PLXNA2	7.44e-05	333	78	8	2.130.10.10
Domain	WD40/YVTN_repeat-like_dom	GTF3C2 DCAF10 PRPF4 WDR87 NBEA HERC1 BIRC6 PLXNA2	7.76e-05	335	78	8	IPR015943
Domain	SH3	RIMBP3 DOCK5 MPP4 ZDHHC6 RIMBP3C RIMBP3B	2.87e-04	216	78	6	SM00326
Domain	SH3_domain	RIMBP3 DOCK5 MPP4 ZDHHC6 RIMBP3C RIMBP3B	3.16e-04	220	78	6	IPR001452
Domain	ARM-type_fold	DOCK5 USP34 MROH8 NBEA HEATR1 PRKDC TAF6	5.34e-04	339	78	7	IPR016024
Domain	WD40	GTF3C2 DCAF10 PRPF4 WDR87 NBEA HERC1	7.48e-04	259	78	6	PF00400
Domain	WD40	GTF3C2 DCAF10 PRPF4 WDR87 NBEA HERC1	8.94e-04	268	78	6	SM00320
Domain	WD40_repeat	GTF3C2 DCAF10 PRPF4 WDR87 NBEA HERC1	9.65e-04	272	78	6	IPR001680
Domain	WD_REPEATS_1	GTF3C2 DCAF10 PRPF4 WDR87 NBEA HERC1	1.08e-03	278	78	6	PS00678
Domain	WD_REPEATS_2	GTF3C2 DCAF10 PRPF4 WDR87 NBEA HERC1	1.10e-03	279	78	6	PS50082
Domain	WD_REPEATS_REGION	GTF3C2 DCAF10 PRPF4 WDR87 NBEA HERC1	1.10e-03	279	78	6	PS50294
Domain	WD40_repeat_dom	GTF3C2 DCAF10 PRPF4 WDR87 NBEA HERC1	1.51e-03	297	78	6	IPR017986
Domain	Kinase-like_dom	TAOK2 FLT1 CAMK2D KSR2 MAP3K14 SRPK3 PRKDC GRK1	1.89e-03	542	78	8	IPR011009
Domain	SH3	RIMBP3 DOCK5 MPP4 RIMBP3C RIMBP3B	2.10e-03	216	78	5	PS50002
Domain	-	PRAMEF7 PRAMEF25 KDM2B PRAMEF12 TLR7 PRAMEF8	2.24e-03	321	78	6	3.80.10.10
Domain	L_dom-like	PRAMEF7 PRAMEF25 KDM2B PRAMEF12 TLR7 PRAMEF8	2.49e-03	328	78	6	IPR032675
Domain	Ser/Thr_kinase_AS	TAOK2 CAMK2D KSR2 MAP3K14 SRPK3 GRK1	3.78e-03	357	78	6	IPR008271
Domain	S_TKc	TAOK2 CAMK2D KSR2 MAP3K14 SRPK3 GRK1	3.89e-03	359	78	6	SM00220
Domain	PROTEIN_KINASE_ST	TAOK2 CAMK2D KSR2 MAP3K14 SRPK3 GRK1	4.05e-03	362	78	6	PS00108
Domain	SH3_9	RIMBP3 RIMBP3C RIMBP3B	4.26e-03	78	78	3	PF14604
Domain	Prot_kinase_dom	TAOK2 FLT1 CAMK2D KSR2 MAP3K14 SRPK3 GRK1	4.31e-03	489	78	7	IPR000719
Domain	PROTEIN_KINASE_DOM	TAOK2 FLT1 CAMK2D KSR2 MAP3K14 SRPK3 GRK1	4.50e-03	493	78	7	PS50011
Domain	WD40_repeat_CS	GTF3C2 DCAF10 PRPF4 HERC1	4.94e-03	164	78	4	IPR019775
Domain	Protein_kinase_ATP_BS	TAOK2 FLT1 CAMK2D MAP3K14 SRPK3 GRK1	5.05e-03	379	78	6	IPR017441
Domain	Pkinase	TAOK2 CAMK2D KSR2 MAP3K14 SRPK3 GRK1	5.18e-03	381	78	6	PF00069
Domain	IPT	PKHD1L1 PLXNA2	5.65e-03	27	78	2	SM00429
Domain	TIG	PKHD1L1 PLXNA2	7.40e-03	31	78	2	PF01833
Domain	IPT	PKHD1L1 PLXNA2	7.87e-03	32	78	2	IPR002909
Pubmed	RIM-BP3 is a manchette-associated protein essential for spermiogenesis.	RIMBP3 RIMBP3C RIMBP3B	6.25e-08	4	88	3	19091768
Pubmed	Structure and evolution of RIM-BP genes: identification of a novel family member.	RIMBP3 RIMBP3C RIMBP3B	1.56e-07	5	88	3	17855024
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	TAOK2 DOC2A VWA5B2 PCSK5 USP34 TMEM259 IL17RE KSR2 INTS11 SREBF1 PRKDC HERC1 BIRC6	4.14e-06	1105	88	13	35748872
Pubmed	Integrative characterization of germ cell-specific genes from mouse spermatocyte UniGene library.	RIMBP3 RIMBP3C RIMBP3B	5.58e-06	14	88	3	17662146
Pubmed	An accessory role of TCRgammadelta (+) cells in the exacerbation of inflammatory bowel disease in TCRalpha mutant mice.	MAP3K14 PRKDC	6.33e-06	2	88	2	11298322
Pubmed	Non-viral reprogramming of fibroblasts into induced pluripotent stem cells by Sleeping Beauty and piggyBac transposons.	PGBD1 PRKDC	6.33e-06	2	88	2	24928388
Pubmed	Differential Expression of VEGFA Isoforms Regulates Metastasis and Response to Anti-VEGFA Therapy in Sarcoma.	FLT1 PRKDC	6.33e-06	2	88	2	28377452
Pubmed	Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.	MAP3K14 PRKDC	6.33e-06	2	88	2	18292290
Pubmed	Differential expression of PRAMEL1, a cancer/testis antigen, during spermatogenesis in the mouse.	PRAMEF7 PRAMEF12 PRAMEF8	1.04e-05	17	88	3	23565261
Pubmed	Mouse Pramel1 regulates spermatogonial development by inhibiting retinoic acid signaling during spermatogenesis.	PRAMEF7 PRAMEF12 PRAMEF8	1.04e-05	17	88	3	37781892
Pubmed	The promoter of the oocyte-specific gene, Oog1, functions in both male and female meiotic germ cells in transgenic mice.	PRAMEF7 PRAMEF12 PRAMEF8	1.24e-05	18	88	3	23894331
Pubmed	Oogenesin is a novel mouse protein expressed in oocytes and early cleavage-stage embryos.	PRAMEF7 PRAMEF12 PRAMEF8	1.24e-05	18	88	3	12890732
Pubmed	Oocyte-specific gene Oog1 suppresses the expression of spermatogenesis-specific genes in oocytes.	PRAMEF7 PRAMEF12 PRAMEF8	1.24e-05	18	88	3	29731491
Pubmed	Identification of a new expanding family of genes characterized by atypical LRR domains. Localization of a cluster preferentially expressed in oocyte.	PRAMEF7 PRAMEF12 PRAMEF8	1.24e-05	18	88	3	14675769
Pubmed	Pramel15 facilitates zygotic nuclear DNMT1 degradation and DNA demethylation.	PRAMEF7 PRAMEF12 PRAMEF8	1.24e-05	18	88	3	39181896
Pubmed	ZAR1 and ZAR2 are required for oocyte meiotic maturation by regulating the maternal transcriptome and mRNA translational activation.	PRAMEF7 ZSCAN5DP PRAMEF12 PRAMEF8	1.46e-05	58	88	4	31598710
Pubmed	Pramel7 mediates ground-state pluripotency through proteasomal-epigenetic combined pathways.	PRAMEF7 PRAMEF12 PRAMEF8	1.47e-05	19	88	3	28604677
Pubmed	Preferentially Expressed Antigen in Melanoma (PRAME) and the PRAME Family of Leucine-Rich Repeat Proteins.	PRAMEF7 PRAMEF12 PRAMEF8	1.73e-05	20	88	3	26694250
Pubmed	Oog1, an oocyte-specific protein, interacts with Ras and Ras-signaling proteins during early embryogenesis.	PRAMEF7 PRAMEF12 PRAMEF8	1.73e-05	20	88	3	16580637
Pubmed	Pramel7 mediates LIF/STAT3-dependent self-renewal in embryonic stem cells.	PRAMEF7 PRAMEF12 PRAMEF8	1.73e-05	20	88	3	21425410
Pubmed	Intestinal gamma delta T cells develop in mice lacking thymus, all lymph nodes, Peyer's patches, and isolated lymphoid follicles.	MAP3K14 PRKDC	1.90e-05	3	88	2	15699117
Pubmed	Sertoli cell-only phenotype and scRNA-seq define PRAMEF12 as a factor essential for spermatogenesis in mice.	PRAMEF7 PRAMEF12 PRAMEF8	2.33e-05	22	88	3	31729367
Pubmed	Oogenesis specific genes (Nobox, Oct4, Bmp15, Gdf9, Oogenesin1 and Oogenesin2) are differentially expressed during natural and gonadotropin-induced mouse follicular development.	PRAMEF7 PRAMEF12 PRAMEF8	2.67e-05	23	88	3	19480014
Pubmed	MAGE-B4, a binding partner of PRAMEF12, is dispensable for spermatogenesis and male fertility in mice.	PRAMEF7 PRAMEF12 PRAMEF8	3.46e-05	25	88	3	37451217
Pubmed	Incomplete reactivation of Oct4-related genes in mouse embryos cloned from somatic nuclei.	PRAMEF7 PRAMEF12 PRAMEF8	3.46e-05	25	88	3	12620990
Pubmed	Inhibition of DNA-dependent protein kinase reduced palmitate and oleate-induced lipid accumulation in HepG2 cells.	SREBF1 PRKDC	3.79e-05	4	88	2	23184344
Pubmed	Homeostatic regulation of intestinal villous epithelia by B lymphocytes.	MAP3K14 PRKDC	3.79e-05	4	88	2	11884426
Pubmed	Identification and characterization of two novel human SCAN domain-containing zinc finger genes ZNF396 and ZNF397.	ZNF24 ZNF396	3.79e-05	4	88	2	12801647
Pubmed	Expression profiling in transgenic FVB/N embryonic stem cells overexpressing STAT3.	PRAMEF7 PRAMEF12 PRAMEF8	3.90e-05	26	88	3	18500982
Pubmed	Differences in gene expression between mouse and human for dynamically regulated genes in early embryo.	PRAMEF7 PRAMEF12 PRAMEF8	4.90e-05	28	88	3	25089626
Pubmed	Thirteen Ovary-Enriched Genes Are Individually Not Essential for Female Fertility in Mice.	PRAMEF7 PRAMEF12 PRAMEF8	6.05e-05	30	88	3	38786026
Pubmed	LSM14B is essential for oocyte meiotic maturation by regulating maternal mRNA storage and clearance.	PRAMEF7 PRAMEF12 PRAMEF8	7.36e-05	32	88	3	37889087
Pubmed	Retinoic acid receptors are required for skeletal growth, matrix homeostasis and growth plate function in postnatal mouse.	PRAMEF7 PRAMEF12 PRAMEF8	9.66e-05	35	88	3	19389355
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	TAOK2 ZNF24 POP4 GTF3C2 ZKSCAN1 DROSHA NOL6 INTS11 KDM2B ECT2L HEATR1 URB2 TAF6	9.81e-05	1497	88	13	31527615
Pubmed	Developmental SMAD6 loss leads to blood vessel hemorrhage and disrupted endothelial cell junctions.	FLT1 SMAD6	1.32e-04	7	88	2	30098998
Pubmed	Progressive loss of the spongiotrophoblast layer of Birc6/Bruce mutants results in embryonic lethality.	FLT1 BIRC6	1.32e-04	7	88	2	15887267
Pubmed	Association and mutation analyses of 16p11.2 autism candidate genes.	TAOK2 DOC2A	1.75e-04	8	88	2	19242545
Pubmed	Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo.	USP34 PRAMEF7 MPP4 PRAMEF12 PRAMEF8 BIRC6	1.84e-04	326	88	6	17015433
Pubmed	Mbd3, a component of the NuRD co-repressor complex, is required for development of pluripotent cells.	PRAMEF7 PRAMEF12 PRAMEF8	2.20e-04	46	88	3	17287250
Pubmed	The ubiquitin-specific protease USP36 SUMOylates EXOSC10 and promotes the nucleolar RNA exosome function in rRNA processing.	POP4 GTF3C2 PRPF4 NOL6 HEATR1 PRKDC URB2	2.30e-04	483	88	7	36912080
Pubmed	A role of DNA-PK for the metabolic gene regulation in response to insulin.	SREBF1 PRKDC	2.81e-04	10	88	2	19303849
Pubmed	DUX is a non-essential synchronizer of zygotic genome activation.	PRAMEF7 PRAMEF12 PRAMEF8	2.81e-04	50	88	3	31806660
Pubmed	Transcriptome analysis of mouse stem cells and early embryos.	USP34 PRAMEF7 ZSCAN5DP PRAMEF12 PRAMEF8 BIRC6	3.27e-04	363	88	6	14691545
Pubmed	Local generation of fumarate promotes DNA repair through inhibition of histone H3 demethylation.	KDM2B PRKDC	3.43e-04	11	88	2	26237645
Pubmed	Sequence- and target-independent angiogenesis suppression by siRNA via TLR3.	FLT1 TLR7	3.43e-04	11	88	2	18368052
Pubmed	The TFIIIC90 subunit of TFIIIC interacts with multiple components of the RNA polymerase III machinery and contains a histone-specific acetyltransferase activity.	GTF3C2 TAF6	4.11e-04	12	88	2	10523658
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	USP34 PRAMEF7 ZNF24 KLHDC3 CAMK2D PRAMEF12 HEATR1 HERC1 PRAMEF8 GEN1	4.15e-04	1084	88	10	11544199
Pubmed	KAP1 facilitates reinstatement of heterochromatin after DNA replication.	DAP3 PRPF4 NOL6 INTS11 HEATR1 PRKDC URB2 BIRC6	4.20e-04	704	88	8	29955894
Pubmed	An abundance of X-linked genes expressed in spermatogonia.	PRAMEF7 PRAMEF12 PRAMEF8	4.59e-04	59	88	3	11279525
Pubmed	EB1-binding-myomegalin protein complex promotes centrosomal microtubules functions.	TAOK2 PRKDC BIRC6	5.57e-04	63	88	3	29162697
Pubmed	High-throughput screening of mouse knockout lines identifies true lean and obese phenotypes.	BRS3 KSR2	6.51e-04	15	88	2	18719666
Pubmed	The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.	GTF3C2 PRPF4 DROSHA NOL6 HEATR1 PRKDC URB2 BIRC6	6.87e-04	759	88	8	35915203
Pubmed	Nucleolar proteome dynamics.	POP4 MROH8 PRPF4 NOL6 PRKDC URB2	6.96e-04	419	88	6	15635413
Pubmed	A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome.	USP34 CCDC60 TOPAZ1 NOL6 HERC1 CTSD	7.04e-04	420	88	6	28065597
Pubmed	The FBXL5-IRP2 axis is integral to control of iron metabolism in vivo.	TMPRSS6 SMAD6	7.42e-04	16	88	2	21907140
Pubmed	Target gene analysis by microarrays and chromatin immunoprecipitation identifies HEY proteins as highly redundant bHLH repressors.	FLT1 SMAD6	8.40e-04	17	88	2	22615585
Pubmed	Genome-wide meta-analysis identifies new susceptibility loci for migraine.	ZDHHC6 KSR2 NBEA	1.04e-03	78	88	3	23793025
Pubmed	A protein-protein interaction map of the TNF-induced NF-κB signal transduction pathway.	PCSK5 PRPF4 MRC2 NOL6 HEATR1	1.04e-03	302	88	5	30561431
Pubmed	Comparative analysis of apoptosis and inflammation genes of mice and humans.	DAP3 TLR7 BIRC6	1.12e-03	80	88	3	12819136
Pubmed	Mfsd2a Is a Transporter for the Essential ω-3 Fatty Acid Docosahexaenoic Acid (DHA) in Eye and Is Important for Photoreceptor Cell Development.	SREBF1 GRK1	1.17e-03	20	88	2	27008858
Pubmed	Assessment of Alzheimer's disease case-control associations using family-based methods.	PGBD1 CTSD	1.41e-03	22	88	2	18830724
Pubmed	A forward genetic screen reveals roles for Nfkbid, Zeb1, and Ruvbl2 in humoral immunity.	MAP3K14 PRKDC	1.55e-03	23	88	2	22761313
Pubmed	Twist1 controls a cell-specification switch governing cell fate decisions within the cardiac neural crest.	PLXNA2 SMAD6	1.83e-03	25	88	2	23555309
Pubmed	Gamma-radiation sensitivity and polymorphisms in RAD51L1 modulate glioma risk.	PRKDC GEN1	2.13e-03	27	88	2	20610542
Pubmed	Conditionals by inversion provide a universal method for the generation of conditional alleles.	FLT1 DROSHA	2.13e-03	27	88	2	23918385
Pubmed	Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins.	TAOK2 FLT1 TLR7	2.18e-03	101	88	3	23382219
Pubmed	Proteomics analysis of nucleolar SUMO-1 target proteins upon proteasome inhibition.	NOL6 PRKDC	2.29e-03	28	88	2	19596686
Pubmed	Functional genomics identifies therapeutic targets for MYC-driven cancer.	CAMK2D CTSD GRK1	2.31e-03	103	88	3	22623531
Pubmed	TRIM65 regulates microRNA activity by ubiquitination of TNRC6.	POP4 GTF3C2 DCAF10 DROSHA NOL6	2.35e-03	364	88	5	24778252
Pubmed	A conserved acetylation switch enables pharmacological control of tubby-like protein stability.	ZNF24 GTF3C2 SLAIN1 BIRC6	2.52e-03	223	88	4	33187986
Interaction	PGBD1 interactions	ZNF24 ZKSCAN1 PGBD1 ZNF396	3.92e-06	29	75	4	int:PGBD1
Cytoband	Ensembl 112 genes in cytogenetic band chr7q11	SPDYE11 SPDYE17 SPDYE10 SPDYE13 SPDYE15 SPDYE8 SPDYE9 SPDYE14	6.21e-08	271	89	8	chr7q11
Cytoband	1p36.21	PRAMEF7 PRAMEF25 PRAMEF12 PRAMEF8	7.20e-06	63	89	4	1p36.21
Cytoband	7q11.23	SPDYE10 SPDYE8 SPDYE9 SPDYE14	3.98e-05	97	89	4	7q11.23
Cytoband	18q12	ZNF24 ZNF396	2.86e-04	13	89	2	18q12
Cytoband	22q11.21	RIMBP3 RIMBP3C RIMBP3B	1.34e-03	111	89	3	22q11.21
GeneFamily	PRAME family	PRAMEF7 PRAMEF25 PRAMEF12 PRAMEF8	6.19e-07	24	52	4	686
GeneFamily	WD repeat domain containing	GTF3C2 DCAF10 PRPF4 WDR87 NBEA HERC1	1.02e-04	262	52	6	362
GeneFamily	Speedy/RINGO cell cycle regulator family	SPDYE8 SPDYE9	5.26e-04	12	52	2	756
GeneFamily	Mitogen-activated protein kinase kinase kinases\|RAF family	TAOK2 MAP3K14	2.15e-03	24	52	2	654
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-2M-Stem_cells-neuroepithelial-like_cells\|Organoid-2M / Sample Type, Dataset, Time_group, and Cell type.	DOCK5 BRS3 TMPRSS6 PGBD1 URB2 GEN1	1.64e-07	127	85	6	9071cd0953c8bb6746dc9cd13d153e3d6ef40b08
Disease	Sacral agenesis	PCSK5 GDF6	1.12e-04	7	69	2	C0344490
Disease	pulmonary non-tuberculous mycobacterial infection	FLT1 TRPM2	8.98e-04	19	69	2	MONDO_0018469
Disease	taurocholate measurement	DOCK5 IDNK	9.96e-04	20	69	2	EFO_0010538
Disease	obsolete_red blood cell distribution width	DOCK5 MROH8 ZKSCAN1 COG1 TMEM259 TMPRSS6 KDM2B HERC1 BIRC6 SMAD6	1.11e-03	1347	69	10	EFO_0005192
Disease	unipolar depression, depressive symptom measurement	ZSCAN31 KSR2	1.69e-03	26	69	2	EFO_0003761, EFO_0007006
Disease	triacylglycerol 50:1 measurement	PCSK5 GTF3C2	1.82e-03	27	69	2	EFO_0010408
Disease	FEV/FEC ratio	PCSK5 USP34 FLT1 ZSCAN31 ZKSCAN1 MRC2 KSR2 HERC1 SMAD6	2.18e-03	1228	69	9	EFO_0004713
Disease	Drug habituation	PRPF4 CSMD3 MYO5C	2.51e-03	115	69	3	C0013170
Disease	Substance-Related Disorders	PRPF4 CSMD3 MYO5C	2.51e-03	115	69	3	C0236969
Disease	Drug abuse	PRPF4 CSMD3 MYO5C	2.51e-03	115	69	3	C0013146
Disease	Drug Use Disorders	PRPF4 CSMD3 MYO5C	2.51e-03	115	69	3	C0013222
Disease	Drug Dependence	PRPF4 CSMD3 MYO5C	2.51e-03	115	69	3	C1510472
Disease	Substance Dependence	PRPF4 CSMD3 MYO5C	2.51e-03	115	69	3	C0038580
Disease	Substance Use Disorders	PRPF4 CSMD3 MYO5C	2.51e-03	115	69	3	C0038586
Disease	Organic Mental Disorders, Substance-Induced	PRPF4 CSMD3 MYO5C	2.51e-03	115	69	3	C0029231
Disease	Prescription Drug Abuse	PRPF4 CSMD3 MYO5C	2.51e-03	115	69	3	C4316881
Disease	heart conduction disease (implicated_via_orthology)	CAMK2D SREBF1	2.55e-03	32	69	2	DOID:10273 (implicated_via_orthology)
Disease	Substance abuse problem	PRPF4 CSMD3 MYO5C	2.57e-03	116	69	3	C0740858

Protein segments in the cluster

Peptide	Gene	Start	Entry
PAWFRCLKTLISLNH	URB2	406	Q14146
IAHLCLQSSLRKWNP	nan	206	Q6ZRG5
SLCPDNEDLLWRKKH	CEP295NL	66	Q96MC4
CQASKTPELHRWLRI	ARSH	151	Q5FYA8
CLSILNTWHGRPEEK	BIRC6	4666	Q9NR09
RLSHEEPLLCEKNHW	CSMD3	1041	Q7Z407
KDHLSDIQRIIWGCP	ECT2L	761	Q008S8
EPLFRQLCALHWLLE	CCDC60	151	Q8IWA6
ALCDLHPSWKEIQAL	RIMBP3B	681	A6NNM3
ALCDLHPSWKEIQAL	RIMBP3C	681	A6NJZ7
LHNPCKWLSRVFIEQ	LINS1	431	Q8NG48
HLGAAWIDKCRPNLL	INTS11	186	Q5TA45
KLRIQNGWLCHLAPE	KSR2	821	Q6VAB6
LDLHLAPLVWKQLCC	HERC1	4596	Q15751
PLKLEAALCQRHDWH	IL17RE	296	Q8NFR9
KFWNDILRKLQPCHS	PCSK5	1171	Q92824
DTDVRHTWKSNCLPL	PLXNA2	1731	O75051
LQLHPKGWATLLRCS	DCAF10	416	Q5QP82
RLQAACHRLKLWPEL	NOL6	481	Q9H6R4
CLLYDLLHSPWLQAL	MPP4	51	Q96JB8
QKPLRWHDALLLCES	MRC2	1141	Q9UBG0
WRLLRKLQKCHNEPA	MROH8	456	Q9H579
ESDLKHLSWCPSIRQ	PRAMEF12	306	O95522
HLSWCPSIRQLKELD	PRAMEF12	311	O95522
WLCVEKLDLLPENHA	FER1L6-AS2	86	Q96M78
QDRIPWLCNLHDILL	IDNK	56	Q5T6J7
LWTRIDLNHCKSITP	KDM2B	1101	Q8NHM5
RKHWSDCLQQPDAAL	DOC2A	366	Q14183
LHAELLQWSDKPCVP	DOCK5	1266	Q9H7D0
NHSWDVLCRRLLEKP	COG1	396	Q8WTW3
SNLWVPSIHCKLLDI	CTSD	101	P07339
QLRCHFTWKLLIEAP	IFIT1B	16	Q5T764
SRSPINCLEHVRDKW	TMEM259	91	Q4ZIN3
WPNHYACEKLLVLLT	GEN1	366	Q17RS7
LDQSCLPHDIRWELN	KLHDC3	351	Q9BQ90
LLKPAQKCLEWLIHR	HEATR1	106	Q9H583
CDKLRAHPLFKDLNW	GRK1	446	Q15835
ESDLKHLSWCPSIRQ	PRAMEF8	306	Q5VWM4
HLSWCPSIRQLKELD	PRAMEF8	311	Q5VWM4
ITASEALKHPWICQR	CAMK2D	261	Q13557
LHKLISPLQCLNHVW	MAP3K14	226	Q99558
LRHQPWKQLCLELRA	GDF6	221	Q6KF10
PDAHLWVKNCRDLLQ	DAP3	156	P51398
LKAHWLSIEGCQPAI	TAF6	131	P49848
ELLKPVWIRCTHSEN	DROSHA	406	Q9NRR4
NLPSLELLIWRCLFH	SLC35G3	66	Q8N808
WLDRCIAAHQRPDKQ	QTRT1	181	Q9BXR0
RWPDLQHAVELKPLC	SMAD6	231	O43541
SWLPLLAKRCHSDTQ	SFRP5	91	Q5T4F7
CWLPLDMELLHRQVL	LMBR1L	261	Q6UX01
ALCDLHPSWKEIQAL	RIMBP3	681	Q9UFD9
KLWSVPDCNLLHTLR	PRPF4	256	O43172
LKQLCDHILFNPAIW	NBEA	591	Q8NFP9
WLKNRTLDEHLTCLL	PRAMEF25	156	A6NGN4
RSHIPLLSELWFQLC	SPDYE10	191	P0DUX0
RSHIPLLSELWFQLC	SPDYE11	191	P0DTA3
RSHIPLLSELWFQLC	SPDYE8	191	P0DUD1
KSLTPLQWCRHVLDN	SLAIN1	201	Q8ND83
PLHELWKQYIRDLCS	POP4	101	O95707
QHPLALLARVWVLCK	TAOK2	1141	Q9UL54
ALAQLRELCHQWLRP	PGBD1	61	Q96JS3
LDLACSLLWNLIRHL	SREBF1	621	P36956
EKRASAADCLQHPWL	SRPK3	551	Q9UPE1
LVALFALCWLPNHLL	BRS3	276	P32247
LLLGDDSCNPSHLWL	CFAP20DC	316	Q6ZVT6
WLCPYKLDLHQRICL	NDUFV1-DT	201	Q8NBR9
ESDLKHLSWCPSIRQ	PRAMEF7	306	Q5VXH5
HLSWCPSIRQLKELD	PRAMEF7	311	Q5VXH5
ENLQELKRLCHWGPI	ZDHHC6	11	Q9H6R6
LCRLWLRPETHTKEQ	ZNF24	76	P17028
RELCHQWLRPEIHTK	ZSCAN31	61	Q96LW9
CHLWLRPDLHTKEQI	ZSCAN5DP	66	P0CG00
RSHIPLLSELWFQLC	SPDYE13	191	A0A494C0Z2
RSHIPLLSELWFQLC	SPDYE14	191	P0DUD3
RSHIPLLSELWFQLC	SPDYE15	191	P0DUD4
RSHIPLLSELWFQLC	SPDYE17	191	P0DUD2
LRQEHWPSFENLLKC	TRPM2	1406	O94759
LKELRISHWPNECIR	nan	76	Q8N8P6
HWNFTDIRCLLPKLS	PKHD1L1	1286	Q86WI1
EKHFNLCLEERDWLP	TLR7	921	Q9NYK1
LDLVKWLLAHCGRPQ	PRKDC	1166	P78527
WPCDRLDVLNRHNLL	TOPAZ1	1446	Q8N9V7
AAKADCWLRAQHLPD	VWA5B2	1191	Q8N398
RSHIPLLSELWFQLC	SPDYE9	191	A0A494C191
PVWKCLHLTKDFREQ	GTF3C2	306	Q8WUA4
REALSRLKELCHQWL	ZKSCAN1	71	P17029
RLKELCHQWLRPEIN	ZKSCAN1	76	P17029
HLALFPKLWTELCQT	USP34	3181	Q70CQ2
LCHLWLRPEVHTKEQ	ZNF396	76	Q96N95
LQCRGEAAHKWSLPE	FLT1	51	P17948
HPSWELFQEICPLLK	WDR87	1281	Q6ZQQ6
LASSCLWHLQGPKDL	TMPRSS6	241	Q8IU80
LREKCLLFSHTVNPW	KLRB1	101	Q12918
CLLPHGTDENWLQKL	MYO5C	511	Q9NQX4
TEEAWKRHLQSPLCK	NECAB2	341	Q7Z6G3