Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ankyrin binding	SPTBN4 SPTB SPTBN1 SCN5A	3.49e-07	23	52	4	GO:0030506
GeneOntologyMolecularFunction	actin filament binding	SPTBN4 MYO1D SPTB SPTBN1 SPTBN2	3.06e-04	227	52	5	GO:0051015
GeneOntologyMolecularFunction	structural constituent of cytoskeleton	SPTBN4 SPTB SPTBN1 SPTBN2	3.65e-04	130	52	4	GO:0005200
GeneOntologyBiologicalProcess	inflammatory response to wounding	TGFB1 TLR4 EXTL3 HMOX1	2.12e-06	38	50	4	GO:0090594
GeneOntologyBiologicalProcess	wound healing involved in inflammatory response	TGFB1 TLR4 HMOX1	3.77e-06	13	50	3	GO:0002246
GeneOntologyBiologicalProcess	actin filament capping	SPTBN4 SPTB SPTBN1 SPTBN2	4.62e-06	46	50	4	GO:0051693
GeneOntologyBiologicalProcess	negative regulation of actin filament depolymerization	SPTBN4 SPTB SPTBN1 SPTBN2	7.59e-06	52	50	4	GO:0030835
GeneOntologyBiologicalProcess	microglia differentiation	TGFB1 TLR4 VPS13A	1.07e-05	18	50	3	GO:0014004
GeneOntologyBiologicalProcess	positive regulation of epithelial cell apoptotic process	TGFB1 HDAC3 ANO6 HMOX1	1.35e-05	60	50	4	GO:1904037
GeneOntologyBiologicalProcess	regulation of actin filament depolymerization	SPTBN4 SPTB SPTBN1 SPTBN2	1.44e-05	61	50	4	GO:0030834
GeneOntologyBiologicalProcess	actin filament depolymerization	SPTBN4 SPTB SPTBN1 SPTBN2	1.97e-05	66	50	4	GO:0030042
GeneOntologyBiologicalProcess	negative regulation of actin filament polymerization	SPTBN4 SPTB SPTBN1 SPTBN2	3.27e-05	75	50	4	GO:0030837
GeneOntologyBiologicalProcess	regulation of actin filament polymerization	SPTBN4 SPTB SPTBN1 SPTBN2 CCR7	3.74e-05	156	50	5	GO:0030833
GeneOntologyBiologicalProcess	dendritic cell chemotaxis	ANO6 CCR7 GPR183	4.68e-05	29	50	3	GO:0002407
GeneOntologyBiologicalProcess	negative regulation of protein depolymerization	SPTBN4 SPTB SPTBN1 SPTBN2	6.41e-05	89	50	4	GO:1901880
GeneOntologyBiologicalProcess	regulation of actin polymerization or depolymerization	SPTBN4 SPTB SPTBN1 SPTBN2 CCR7	6.82e-05	177	50	5	GO:0008064
GeneOntologyBiologicalProcess	negative regulation of protein polymerization	SPTBN4 SPTB SPTBN1 SPTBN2	6.99e-05	91	50	4	GO:0032272
GeneOntologyBiologicalProcess	regulation of cellular component size	SPTBN4 ANO6 SPTB SPTBN1 SPTBN2 CCR7 TTC3	7.08e-05	426	50	7	GO:0032535
GeneOntologyBiologicalProcess	regulation of actin filament length	SPTBN4 SPTB SPTBN1 SPTBN2 CCR7	7.38e-05	180	50	5	GO:0030832
GeneOntologyBiologicalProcess	regulation of actin filament-based process	TGFB1 SPTBN4 SPTB SPTBN1 SPTBN2 SCN5A CCR7	8.43e-05	438	50	7	GO:0032970
GeneOntologyBiologicalProcess	dendritic cell migration	ANO6 CCR7 GPR183	9.05e-05	36	50	3	GO:0036336
GeneOntologyBiologicalProcess	actin filament polymerization	SPTBN4 SPTB SPTBN1 SPTBN2 CCR7	9.53e-05	190	50	5	GO:0030041
GeneOntologyBiologicalProcess	negative regulation of protein-containing complex disassembly	SPTBN4 SPTB SPTBN1 SPTBN2	1.01e-04	100	50	4	GO:0043242
GeneOntologyBiologicalProcess	myeloid leukocyte differentiation	TGFB1 TLR4 VPS13A CCR7 GPR183 TNFRSF11B	1.04e-04	312	50	6	GO:0002573
GeneOntologyBiologicalProcess	tolerance induction to self antigen	TGFB1 CCR7	1.20e-04	7	50	2	GO:0002513
GeneOntologyBiologicalProcess	regulation of protein depolymerization	SPTBN4 SPTB SPTBN1 SPTBN2	1.22e-04	105	50	4	GO:1901879
GeneOntologyBiologicalProcess	regulation of protein-containing complex assembly	TGFB1 SPTBN4 SPTB SPTBN1 SPTBN2 TLR4 CCR7	1.67e-04	489	50	7	GO:0043254
GeneOntologyBiologicalProcess	multicellular organismal-level homeostasis	TGFB1 HDAC3 TLR4 VPS13A TRPM8 CCR7 GPR183 HMOX1 DYNC1H1 TNFRSF11B	1.69e-04	1043	50	10	GO:0048871
GeneOntologyBiologicalProcess	actin polymerization or depolymerization	SPTBN4 SPTB SPTBN1 SPTBN2 CCR7	1.97e-04	222	50	5	GO:0008154
GeneOntologyBiologicalProcess	positive regulation of transport	TGFB1 CACNA1B HDAC3 GALR1 LIPG ANO6 TLR4 SCN5A CCR7 DYNC1H1	2.26e-04	1081	50	10	GO:0051050
GeneOntologyBiologicalProcess	regulation of protein polymerization	SPTBN4 SPTB SPTBN1 SPTBN2 CCR7	2.37e-04	231	50	5	GO:0032271
GeneOntologyBiologicalProcess	interleukin-23 production	TGFB1 TLR4	2.56e-04	10	50	2	GO:0032627
GeneOntologyBiologicalProcess	regulation of interleukin-23 production	TGFB1 TLR4	2.56e-04	10	50	2	GO:0032667
GeneOntologyBiologicalProcess	regulation of actin cytoskeleton organization	TGFB1 SPTBN4 SPTB SPTBN1 SPTBN2 CCR7	3.19e-04	384	50	6	GO:0032956
GeneOntologyBiologicalProcess	chemokine production	TGFB1 TLR4 VPS13A HMOX1	3.20e-04	135	50	4	GO:0032602
GeneOntologyBiologicalProcess	protein depolymerization	SPTBN4 SPTB SPTBN1 SPTBN2	4.09e-04	144	50	4	GO:0051261
GeneOntologyBiologicalProcess	regulation of protein-containing complex disassembly	SPTBN4 SPTB SPTBN1 SPTBN2	4.09e-04	144	50	4	GO:0043244
GeneOntologyBiologicalProcess	regulation of cytoskeleton organization	TGFB1 SPTBN4 SPTB SPTBN1 SPTBN2 CCR7 DYNC1H1	4.64e-04	579	50	7	GO:0051493
GeneOntologyBiologicalProcess	regulation of cold-induced thermogenesis	HDAC3 TLR4 TRPM8 DYNC1H1	5.02e-04	152	50	4	GO:0120161
GeneOntologyBiologicalProcess	regulation of epithelial cell apoptotic process	TGFB1 HDAC3 ANO6 HMOX1	5.02e-04	152	50	4	GO:1904035
GeneOntologyBiologicalProcess	cold-induced thermogenesis	HDAC3 TLR4 TRPM8 DYNC1H1	5.53e-04	156	50	4	GO:0106106
GeneOntologyBiologicalProcess	positive regulation of chemokine (C-X-C motif) ligand 2 production	TGFB1 TLR4	5.93e-04	15	50	2	GO:2000343
GeneOntologyBiologicalProcess	osteoclast differentiation	TGFB1 TLR4 GPR183 TNFRSF11B	6.37e-04	162	50	4	GO:0030316
GeneOntologyBiologicalProcess	protein-containing complex disassembly	SPTBN4 SPTB SPTBN1 SPTBN2 SUPT16H	6.81e-04	291	50	5	GO:0032984
GeneOntologyBiologicalProcess	regulation of anatomical structure size	SPTBN4 ANO6 SPTB SPTBN1 SPTBN2 CCR7 TTC3	6.84e-04	618	50	7	GO:0090066
GeneOntologyBiologicalProcess	negative regulation of cytokine production	TGFB1 HDAC3 TLR4 CCR7 EXTL3 HMOX1	6.86e-04	444	50	6	GO:0001818
GeneOntologyBiologicalProcess	myeloid leukocyte cytokine production	TGFB1 TLR4 HMOX1	7.11e-04	72	50	3	GO:0061082
GeneOntologyBiologicalProcess	regulation of actin filament organization	SPTBN4 SPTB SPTBN1 SPTBN2 CCR7	7.81e-04	300	50	5	GO:0110053
GeneOntologyBiologicalProcess	negative regulation of protein-containing complex assembly	SPTBN4 SPTB SPTBN1 SPTBN2	8.15e-04	173	50	4	GO:0031333
GeneOntologyBiologicalProcess	phospholipid homeostasis	TGFB1 LIPG	8.60e-04	18	50	2	GO:0055091
GeneOntologyBiologicalProcess	macrophage differentiation	TGFB1 TLR4 VPS13A	8.64e-04	77	50	3	GO:0030225
GeneOntologyBiologicalProcess	adaptive thermogenesis	HDAC3 TLR4 TRPM8 DYNC1H1	8.69e-04	176	50	4	GO:1990845
GeneOntologyCellularComponent	spectrin	SPTBN4 SPTB SPTBN1 SPTBN2	3.92e-09	9	51	4	GO:0008091
GeneOntologyCellularComponent	spectrin-associated cytoskeleton	SPTB SPTBN1 SPTBN2	1.14e-06	9	51	3	GO:0014731
GeneOntologyCellularComponent	cortical actin cytoskeleton	SPTBN4 SPTB SPTBN1 SPTBN2	7.82e-05	93	51	4	GO:0030864
GeneOntologyCellularComponent	cell cortex	SPTBN4 MYO1D SPTB SPTBN1 SPTBN2 DYNC1H1	2.76e-04	371	51	6	GO:0005938
GeneOntologyCellularComponent	cortical cytoskeleton	SPTBN4 SPTB SPTBN1 SPTBN2	2.76e-04	129	51	4	GO:0030863
GeneOntologyCellularComponent	axolemma	MYO1D SPTBN1	1.19e-03	21	51	2	GO:0030673
GeneOntologyCellularComponent	cell surface	TGFB1 ADGRG2 LIPG ANO6 SPTB TLR4 SCN5A TRPM8 CCR7	1.32e-03	1111	51	9	GO:0009986
GeneOntologyCellularComponent	main axon	SPTBN4 MYO1D SPTBN1	1.34e-03	89	51	3	GO:0044304
MousePheno	renal tubular necrosis	TGFB1 SPTB TLR4 HMOX1	3.68e-07	21	41	4	MP:0004154
MousePheno	renal necrosis	TGFB1 SPTB TLR4 HMOX1	1.65e-06	30	41	4	MP:0003946
MousePheno	decreased dendritic cell number	TGFB1 VPS13A CCR7 GPR183	5.67e-05	72	41	4	MP:0008127
Domain	Spectrin_bsu	SPTBN4 SPTB SPTBN1 SPTBN2	5.34e-11	4	52	4	IPR016343
Domain	Actinin_actin-bd_CS	SPTBN4 SPTB SPTBN1 SPTBN2	4.55e-07	23	52	4	IPR001589
Domain	Spectrin	SPTBN4 SPTB SPTBN1 SPTBN2	4.55e-07	23	52	4	PF00435
Domain	ACTININ_2	SPTBN4 SPTB SPTBN1 SPTBN2	4.55e-07	23	52	4	PS00020
Domain	ACTININ_1	SPTBN4 SPTB SPTBN1 SPTBN2	4.55e-07	23	52	4	PS00019
Domain	Spectrin_repeat	SPTBN4 SPTB SPTBN1 SPTBN2	1.21e-06	29	52	4	IPR002017
Domain	PH_dom-spectrin-type	SPTBN4 SPTBN1 SPTBN2	1.69e-06	9	52	3	IPR001605
Domain	Spectrin/alpha-actinin	SPTBN4 SPTB SPTBN1 SPTBN2	1.81e-06	32	52	4	IPR018159
Domain	SPEC	SPTBN4 SPTB SPTBN1 SPTBN2	1.81e-06	32	52	4	SM00150
Domain	CH	SPTBN4 SPTB SPTBN1 SPTBN2	3.19e-05	65	52	4	SM00033
Domain	CH	SPTBN4 SPTB SPTBN1 SPTBN2	4.28e-05	70	52	4	PF00307
Domain	-	SPTBN4 SPTB SPTBN1 SPTBN2	4.52e-05	71	52	4	1.10.418.10
Domain	CH	SPTBN4 SPTB SPTBN1 SPTBN2	5.04e-05	73	52	4	PS50021
Domain	CH-domain	SPTBN4 SPTB SPTBN1 SPTBN2	5.61e-05	75	52	4	IPR001715
Domain	Ion_trans_dom	CACNA1B SCN5A TRPM8	3.94e-03	114	52	3	IPR005821
Domain	Ion_trans	CACNA1B SCN5A TRPM8	3.94e-03	114	52	3	PF00520
Pathway	REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS	SPTBN4 SPTB SPTBN1 SPTBN2	1.41e-08	10	42	4	MM15112
Pathway	REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS	SPTBN4 SPTB SPTBN1 SPTBN2 SCN5A	2.95e-08	31	42	5	M877
Pathway	REACTOME_NCAM_SIGNALING_FOR_NEURITE_OUT_GROWTH	SPTBN4 SPTB SPTBN1 SPTBN2	4.67e-06	38	42	4	MM14969
Pathway	REACTOME_COPI_MEDIATED_ANTEROGRADE_TRANSPORT	SPTBN4 SPTB SPTBN1 SPTBN2 DYNC1H1	1.24e-05	102	42	5	M27648
Pathway	REACTOME_COPI_MEDIATED_ANTEROGRADE_TRANSPORT	SPTBN4 SPTB SPTBN1 SPTBN2 DYNC1H1	1.78e-05	110	42	5	MM15350
Pathway	REACTOME_L1CAM_INTERACTIONS	SPTBN4 SPTB SPTBN1 SPTBN2 SCN5A	2.83e-05	121	42	5	M872
Pathway	REACTOME_NCAM_SIGNALING_FOR_NEURITE_OUT_GROWTH	SPTBN4 SPTB SPTBN1 SPTBN2	3.57e-05	63	42	4	M11187
Pathway	REACTOME_L1CAM_INTERACTIONS	SPTBN4 SPTB SPTBN1 SPTBN2	4.83e-05	68	42	4	MM14968
Pathway	WP_COVID19_AND_ENDOTHELIAL_CELL_SENESCENCE	ANO6 TLR4	8.62e-05	5	42	2	M46464
Pathway	REACTOME_ER_TO_GOLGI_ANTEROGRADE_TRANSPORT	SPTBN4 SPTB SPTBN1 SPTBN2 DYNC1H1	9.51e-05	156	42	5	M27097
Pathway	REACTOME_HIV_ELONGATION_ARREST_AND_RECOVERY	GTF2F2 POLR2B SUPT16H	1.26e-04	33	42	3	M27010
Pathway	REACTOME_ER_TO_GOLGI_ANTEROGRADE_TRANSPORT	SPTBN4 SPTB SPTBN1 SPTBN2 DYNC1H1	1.35e-04	168	42	5	MM14785
Pathway	REACTOME_TRANSPORT_TO_THE_GOLGI_AND_SUBSEQUENT_MODIFICATION	SPTBN4 SPTB SPTBN1 SPTBN2 DYNC1H1	2.22e-04	187	42	5	M961
Pathway	REACTOME_INFECTIOUS_DISEASE	TGFB1 HDAC3 GTF2F2 ANO6 POLR2B TLR4 SUPT16H RNF213 NUP188 HMOX1 DYNC1H1	2.39e-04	1081	42	11	M27548
Pathway	WP_OPIOID_RECEPTOR_PATHWAYS	CACNA1B TLR4 HMOX1	2.42e-04	41	42	3	M48338
Pathway	REACTOME_HIV_TRANSCRIPTION_ELONGATION	GTF2F2 POLR2B SUPT16H	2.79e-04	43	42	3	M29569
Pathway	REACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS	GTF2F2 POLR2B NUP188	2.99e-04	44	42	3	M109
Pathway	REACTOME_TRANSPORT_TO_THE_GOLGI_AND_SUBSEQUENT_MODIFICATION	SPTBN4 SPTB SPTBN1 SPTBN2 DYNC1H1	3.18e-04	202	42	5	MM15650
Pathway	REACTOME_TP53_REGULATES_TRANSCRIPTION_OF_DNA_REPAIR_GENES	GTF2F2 POLR2B SUPT16H	3.64e-04	47	42	3	MM15328
Pathway	REACTOME_HEME_SIGNALING	HDAC3 TLR4 HMOX1	4.12e-04	49	42	3	M41832
Pathway	REACTOME_FORMATION_OF_RNA_POL_II_ELONGATION_COMPLEX	GTF2F2 POLR2B SUPT16H	6.77e-04	58	42	3	M805
Pathway	REACTOME_FORMATION_OF_RNA_POL_II_ELONGATION_COMPLEX	GTF2F2 POLR2B SUPT16H	7.12e-04	59	42	3	MM14504
Pathway	REACTOME_TP53_REGULATES_TRANSCRIPTION_OF_DNA_REPAIR_GENES	GTF2F2 POLR2B SUPT16H	8.23e-04	62	42	3	M27618
Pathway	REACTOME_HIV_LIFE_CYCLE	GTF2F2 POLR2B SUPT16H NUP188	9.82e-04	149	42	4	M4076
Pathway	REACTOME_VIRAL_INFECTION_PATHWAYS	TGFB1 HDAC3 GTF2F2 ANO6 POLR2B TLR4 SUPT16H NUP188 DYNC1H1	1.01e-03	888	42	9	M48034
Pathway	WP_PLATELETMEDIATED_INTERACTIONS_WITH_VASCULAR_AND_CIRCULATING_CELLS	TGFB1 TLR4	1.15e-03	17	42	2	M39807
Pathway	REACTOME_TRANSCRIPTION_OF_THE_HIV_GENOME	GTF2F2 POLR2B SUPT16H	1.17e-03	70	42	3	M27008
Pathway	REACTOME_INFLUENZA_INFECTION	TGFB1 GTF2F2 POLR2B NUP188	1.19e-03	157	42	4	M4669
Pathway	REACTOME_FGFR2_ALTERNATIVE_SPLICING	GTF2F2 POLR2B	1.29e-03	18	42	2	MM15334
Pathway	WP_EXTRAFOLLICULAR_AND_FOLLICULAR_B_CELL_ACTIVATION_BY_SARSCOV2	TLR4 CCR7 GPR183	1.38e-03	74	42	3	M45517
Pathway	REACTOME_SIGNALING_BY_FGFR2_IIIA_TM	GTF2F2 POLR2B	1.43e-03	19	42	2	M27739
Pathway	WP_ESTROGEN_SIGNALING	HDAC3 GTF2F2 POLR2B	1.54e-03	77	42	3	MM15934
Pathway	REACTOME_ASPARAGINE_N_LINKED_GLYCOSYLATION	SPTBN4 SPTB SPTBN1 SPTBN2 DYNC1H1	1.70e-03	293	42	5	MM15120
Pathway	REACTOME_RNA_POLYMERASE_II_PRE_TRANSCRIPTION_EVENTS	GTF2F2 POLR2B SUPT16H	1.79e-03	81	42	3	M865
Pathway	REACTOME_RNA_POLYMERASE_II_PRE_TRANSCRIPTION_EVENTS	GTF2F2 POLR2B SUPT16H	1.91e-03	83	42	3	MM15314
Pathway	REACTOME_ASPARAGINE_N_LINKED_GLYCOSYLATION	SPTBN4 SPTB SPTBN1 SPTBN2 DYNC1H1	2.08e-03	307	42	5	M894
Pathway	REACTOME_ABORTIVE_ELONGATION_OF_HIV_1_TRANSCRIPT_IN_THE_ABSENCE_OF_TAT	GTF2F2 POLR2B	2.11e-03	23	42	2	M3630
Pathway	REACTOME_DISEASES_OF_SIGNAL_TRANSDUCTION_BY_GROWTH_FACTOR_RECEPTORS_AND_SECOND_MESSENGERS	TGFB1 HDAC3 GTF2F2 POLR2B SPTBN1 RNF213	2.36e-03	464	42	6	M27547
Pathway	REACTOME_MEMBRANE_TRAFFICKING	SPTBN4 KIF26B SPTB SPTBN1 SPTBN2 DYNC1H1 DENND3	2.37e-03	630	42	7	M11480
Pubmed	Brain proteins interacting with the tetramerization region of non-erythroid alpha spectrin.	SPTBN4 SPTB SPTBN1 SPTBN2	1.45e-09	11	52	4	17607528
Pubmed	alphaII-betaV spectrin bridges the plasma membrane and cortical lattice in the lateral wall of the auditory outer hair cells.	SPTBN4 SPTB SPTBN1 SPTBN2	3.14e-09	13	52	4	18796539
Pubmed	A new spectrin, beta IV, has a major truncated isoform that associates with promyelocytic leukemia protein nuclear bodies and the nuclear matrix.	SPTBN4 SPTB SPTBN1	3.15e-09	3	52	3	11294830
Pubmed	β spectrin-dependent and domain specific mechanisms for Na+ channel clustering.	SPTBN4 SPTB SPTBN1	3.15e-09	3	52	3	32425157
Pubmed	Reciprocal regulation by TLR4 and TGF-β in tumor-initiating stem-like cells.	TGFB1 SPTBN1 TLR4	3.15e-09	3	52	3	23921128
Pubmed	Apparent structural differences at the tetramerization region of erythroid and nonerythroid beta spectrin as discriminated by phage displayed scFvs.	SPTB SPTBN1 SPTBN2	1.26e-08	4	52	3	21412925
Pubmed	Organization of focal adhesion plaques is disrupted by action of the HIV-1 protease.	SPTBN4 SPTB SPTBN1 SPTBN2	1.34e-08	18	52	4	12119179
Pubmed	TGF-β/β2-spectrin/CTCF-regulated tumor suppression in human stem cell disorder Beckwith-Wiedemann syndrome.	TGFB1 SPTBN1 SPTBN2	3.15e-08	5	52	3	26784546
Pubmed	Cell organization, growth, and neural and cardiac development require αII-spectrin.	SPTB SPTBN1 SPTBN2	3.75e-07	10	52	3	22159418
Pubmed	Loss of Hdac3 in osteoprogenitors increases bone expression of osteoprotegerin, improving systemic insulin sensitivity.	HDAC3 TNFRSF11B	2.19e-06	2	52	2	28840938
Pubmed	TRESK K+ Channel Activity Regulates Trigeminal Nociception and Headache.	KCNK18 TRPM8	2.19e-06	2	52	2	31308053
Pubmed	Hepatocellular cancer arises from loss of transforming growth factor beta signaling adaptor protein embryonic liver fodrin through abnormal angiogenesis.	TGFB1 SPTBN1	2.19e-06	2	52	2	18704924
Pubmed	Heme oxygenase-1 induction mitigates burn-associated early acute kidney injury via the TLR4 signaling pathway.	TLR4 HMOX1	2.19e-06	2	52	2	33962830
Pubmed	Association of reduced heme oxygenase-1 with excessive Toll-like receptor 4 expression in peripheral blood mononuclear cells in Behçet's disease.	TLR4 HMOX1	2.19e-06	2	52	2	18234118
Pubmed	Lipopolysaccaride induces autophagic signaling in macrophages via a TLR4, heme oxygenase-1 dependent pathway.	TLR4 HMOX1	2.19e-06	2	52	2	21307647
Pubmed	Crosstalk Between Transforming Growth Factor Beta-2 and Toll-Like Receptor 4 in the Trabecular Meshwork.	TGFB1 TLR4	2.19e-06	2	52	2	28346614
Pubmed	Heme Oxygenase-1 may Mediate Early Inflammatory Response of Intracerebral Hemorrhage through Toll-like Receptor 4 Signaling Pathway.	TLR4 HMOX1	2.19e-06	2	52	2	35702793
Pubmed	HDAC-mediated control of ERK- and PI3K-dependent TGF-β-induced extracellular matrix-regulating genes.	TGFB1 HDAC3	2.19e-06	2	52	2	20470885
Pubmed	C-reactive protein promotes inflammation through TLR4/NF-κB/TGF-β pathway in HL-1 cells.	TGFB1 TLR4	2.19e-06	2	52	2	31391207
Pubmed	Vitreous induces heme oxygenase-1 expression mediated by transforming growth factor-beta and reactive oxygen species generation in human retinal pigment epithelial cells.	TGFB1 HMOX1	2.19e-06	2	52	2	17277740
Pubmed	Caspase-3/7-mediated Cleavage of β2-spectrin is Required for Acetaminophen-induced Liver Damage.	SPTBN1 SPTBN2	2.19e-06	2	52	2	26884715
Pubmed	Heme Oxygenase-1 Protects the Liver from Septic Injury by Modulating TLR4-Mediated Mitochondrial Quality Control in Mice.	TLR4 HMOX1	2.19e-06	2	52	2	29028772
Pubmed	Attenuation of transforming growth factor-β-stimulated collagen production in fibroblasts by quercetin-induced heme oxygenase-1.	TGFB1 HMOX1	2.19e-06	2	52	2	21216973
Pubmed	The prognostic value of combined TGF-β1 and ELF in hepatocellular carcinoma.	TGFB1 SPTBN1	2.19e-06	2	52	2	25880619
Pubmed	TGFβ-Responsive HMOX1 Expression Is Associated with Stemness and Invasion in Glioblastoma Multiforme.	TGFB1 HMOX1	2.19e-06	2	52	2	27354342
Pubmed	HMOX-1 inhibits TGF-β-induced epithelial-mesenchymal transition in the MCF-7 breast cancer cell line.	TGFB1 HMOX1	2.19e-06	2	52	2	28627599
Pubmed	CCR7 enhances TGF-β1-induced epithelial-mesenchymal transition and is associated with lymph node metastasis and poor overall survival in gastric cancer.	TGFB1 CCR7	2.19e-06	2	52	2	26176983
Pubmed	Heme oxygenase-1 mediated cytoprotection against liver ischemia and reperfusion injury: inhibition of type-1 interferon signaling.	TLR4 HMOX1	2.19e-06	2	52	2	17589347
Pubmed	Specificity protein 1 and Smad-dependent regulation of human heme oxygenase-1 gene by transforming growth factor-beta1 in renal epithelial cells.	TGFB1 HMOX1	2.19e-06	2	52	2	17567933
Pubmed	Utilization of spectrins βI and βIII in diagnosis of hepatocellular carcinoma.	SPTB SPTBN2	2.19e-06	2	52	2	30798076
Pubmed	Inhibition of precursor B-cell malignancy progression by toll-like receptor ligand-induced immune responses.	TGFB1 TLR4	2.19e-06	2	52	2	27220664
Pubmed	Graphene oxide polarizes iNKT cells for production of TGFβ and attenuates inflammation in an iNKT cell-mediated sepsis model.	TGFB1 TLR4	2.19e-06	2	52	2	29973666
Pubmed	Epstein-Barr virus-induced genes: first lymphocyte-specific G protein-coupled peptide receptors.	CCR7 GPR183	2.19e-06	2	52	2	8383238
Pubmed	CCR7 Mediates TGF-β1-Induced Human Malignant Glioma Invasion, Migration, and Epithelial-Mesenchymal Transition by Activating MMP2/9 Through the Nuclear Factor KappaB Signaling Pathway.	TGFB1 CCR7	2.19e-06	2	52	2	28817313
Pubmed	Saucerneol D inhibits dendritic cell activation by inducing heme oxygenase-1, but not by directly inhibiting toll-like receptor 4 signaling.	TLR4 HMOX1	2.19e-06	2	52	2	25792017
Pubmed	[Effect of lutein on relieving oxidative stress in mice induced by D-galatose].	TLR4 HMOX1	2.19e-06	2	52	2	20726230
Pubmed	TLR4 signaling-induced heme oxygenase upregulation in the acute lung injury: role in hemorrhagic shock and two-hit induced lung inflammation.	TLR4 HMOX1	2.19e-06	2	52	2	23065289
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	TPP2 MYO1D USP11 SPTBN1 SPTBN2 PDCD11 NUP188 DYNC1H1	5.38e-06	653	52	8	22586326
Pubmed	4,7-Dimethoxy-5-methyl-1,3-benzodioxole from Antrodia camphorata inhibits LPS-induced inflammation via suppression of NF-κB and induction HO-1 in RAW264.7 cells.	TLR4 HMOX1	6.57e-06	3	52	2	26745712
Pubmed	De-ubiquitinating enzyme, USP11, promotes transforming growth factor β-1 signaling through stabilization of transforming growth factor β receptor II.	TGFB1 USP11	6.57e-06	3	52	2	27853171
Pubmed	High glucose promotes tumor invasion and increases metastasis-associated protein expression in human lung epithelial cells by upregulating heme oxygenase-1 via reactive oxygen species or the TGF-β1/PI3K/Akt signaling pathway.	TGFB1 HMOX1	6.57e-06	3	52	2	25661467
Pubmed	Microbiota-derived metabolite promotes HDAC3 activity in the gut.	HDAC3 TLR4	6.57e-06	3	52	2	32731255
Pubmed	Obesity- and aging-induced excess of central transforming growth factor-β potentiates diabetic development via an RNA stress response.	TGFB1 TLR4	6.57e-06	3	52	2	25086906
Pubmed	EBI2 operates independently of but in cooperation with CXCR5 and CCR7 to direct B cell migration and organization in follicles and the germinal center.	CCR7 GPR183	6.57e-06	3	52	2	21948984
Pubmed	TGF-beta1 stimulates HO-1 via the p38 mitogen-activated protein kinase in A549 pulmonary epithelial cells.	TGFB1 HMOX1	6.57e-06	3	52	2	12376363
Pubmed	Tenascin-C Participates Pulmonary Injury Induced by Paraquat Through Regulating TLR4 and TGF-β Signaling Pathways.	TGFB1 TLR4	6.57e-06	3	52	2	34463846
Pubmed	Activation of dendritic cells by human papillomavirus-like particles through TLR4 and NF-kappaB-mediated signalling, moderated by TGF-beta.	TGFB1 TLR4	6.57e-06	3	52	2	15661045
Pubmed	Transforming growth factor β1 enhances heme oxygenase 1 expression in human synovial fibroblasts by inhibiting microRNA 519b synthesis.	TGFB1 HMOX1	6.57e-06	3	52	2	28423042
Pubmed	Toll-like receptor 4 regulates heme oxygenase-1 expression after hemorrhagic shock induced acute lung injury in mice: requirement of p38 mitogen-activated protein kinase activation.	TLR4 HMOX1	6.57e-06	3	52	2	18827744
Pubmed	High mobility group box 1 activates Toll like receptor 4 signaling in hepatic stellate cells.	TGFB1 TLR4	6.57e-06	3	52	2	22841886
Pubmed	Transforming growth factor-beta differentially inhibits MyD88-dependent, but not TRAM- and TRIF-dependent, lipopolysaccharide-induced TLR4 signaling.	TGFB1 TLR4	6.57e-06	3	52	2	15623538
Pubmed	Increased expression of inflammatory genes in the neonatal mouse brain after hyperoxic reoxygenation.	TGFB1 HMOX1	6.57e-06	3	52	2	25423075
Pubmed	Osteoprotegerin Expression in Liver is Induced by IL13 through TGFβ.	TGFB1 TNFRSF11B	6.57e-06	3	52	2	35060690
Pubmed	TGF-beta1 Inhibits TLR-mediated odontoblast responses to oral bacteria.	TGFB1 TLR4	6.57e-06	3	52	2	19407153
Pubmed	Heme oxygenase-1 upregulation improves lipopolysaccharide-induced acute lung injury involving suppression of macrophage migration inhibitory factor.	TLR4 HMOX1	6.57e-06	3	52	2	20638132
Pubmed	Sodium Channel Nav1.5 Controls Epithelial-to-Mesenchymal Transition and Invasiveness in Breast Cancer Cells Through its Regulation by the Salt-Inducible Kinase-1.	TGFB1 SCN5A	6.57e-06	3	52	2	31819138
Pubmed	USP11 Enhances TGFβ-Induced Epithelial-Mesenchymal Plasticity and Human Breast Cancer Metastasis.	TGFB1 USP11	6.57e-06	3	52	2	29724812
Pubmed	Downregulation of IL7R, CCR7, and TLR4 in the cord blood of children with respiratory syncytial virus disease.	TLR4 CCR7	6.57e-06	3	52	2	23888080
Pubmed	TGF-β1-induced EMT promotes targeted migration of breast cancer cells through the lymphatic system by the activation of CCR7/CCL21-mediated chemotaxis.	TGFB1 CCR7	6.57e-06	3	52	2	25961925
Pubmed	LPS/TLR4 Signaling Enhances TGF-β Response Through Downregulating BAMBI During Prostatic Hyperplasia.	TGFB1 TLR4	6.57e-06	3	52	2	27243216
Pubmed	Impaired reciprocal regulation between SIRT6 and TGF-β signaling in fatty liver.	TGFB1 SPTBN1	6.57e-06	3	52	2	35506565
Pubmed	Rosiglitazone Regulates TLR4 and Rescues HO-1 and NRF2 Expression in Myometrial and Decidual Macrophages in Inflammation-Induced Preterm Birth.	TLR4 HMOX1	6.57e-06	3	52	2	28322133
Pubmed	Regional and mucosal memory T cells.	TGFB1 CCR7	6.57e-06	3	52	2	21739671
Pubmed	Adipose-derived mesenchymal stem cells protect against CMS-induced depression-like behaviors in mice via regulating the Nrf2/HO-1 and TLR4/NF-κB signaling pathways.	TLR4 HMOX1	6.57e-06	3	52	2	31796867
Pubmed	The complete amino acid sequence for brain beta spectrin (beta fodrin): relationship to globin sequences.	SPTB SPTBN1	6.57e-06	3	52	2	8479293
Pubmed	TLR4 signaling pathway in mouse Lewis lung cancer cells promotes the expression of TGF-β1 and IL-10 and tumor cells migration.	TGFB1 TLR4	6.57e-06	3	52	2	24211974
Pubmed	Osteoprotegerin promotes vascular fibrosis via a TGF-β1 autocrine loop.	TGFB1 TNFRSF11B	6.57e-06	3	52	2	21679949
Pubmed	Nodal β spectrins are required to maintain Na+ channel clustering and axon integrity.	SPTBN4 SPTB	6.57e-06	3	52	2	32052742
Pubmed	Developmental expression of brain beta-spectrin isoform messenger RNAs.	SPTB SPTBN1	6.57e-06	3	52	2	1467942
Pubmed	The influence of the genetic and non-genetic factors on bone mineral density and osteoporotic fractures in Chinese women.	SPTBN1 TNFRSF11B	6.57e-06	3	52	2	22798246
Pubmed	Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2.	SPTBN4 SPTB SPTBN1	7.08e-06	25	52	3	8493579
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	TPP2 NCAPG POLR2B SPTBN1 SPTBN2 SUPT16H PDCD11 RNF213 NUP188 EXTL3 DYNC1H1	7.46e-06	1440	52	11	30833792
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	HDAC3 MYO1D USP11 POLR2B SUPT16H VPS13A PDCD11 RNF213 NUP188 DDX55 TTC3	1.07e-05	1496	52	11	32877691
Pubmed	Competitive binding of E3 ligases TRIM26 and WWP2 controls SOX2 in glioblastoma.	TGFB1 GALE SPTB SPTBN2 MARF1 PDCD11 HMOX1 TTC3	1.23e-05	732	52	8	34732716
Pubmed	HO-1-STAT3 axis in mouse liver ischemia/reperfusion injury: regulation of TLR4 innate responses through PI3K/PTEN signaling.	TLR4 HMOX1	1.31e-05	4	52	2	21756853
Pubmed	TTC3 contributes to TGF-β1-induced epithelial-mesenchymal transition and myofibroblast differentiation, potentially through SMURF2 ubiquitylation and degradation.	TGFB1 TTC3	1.31e-05	4	52	2	30696809
Pubmed	Expression of Toll-like receptors 2 and 4 and the OPG-RANKL-RANK system in inflammatory external root resorption and external cervical resorption.	TLR4 TNFRSF11B	1.31e-05	4	52	2	23521017
Pubmed	Visualization of T Cell Migration in the Spleen Reveals a Network of Perivascular Pathways that Guide Entry into T Zones.	TLR4 CCR7	1.31e-05	4	52	2	32298648
Pubmed	TLR4 mediates LPS-induced HO-1 expression in mouse liver: role of TNF-alpha and IL-1beta.	TLR4 HMOX1	1.31e-05	4	52	2	12918124
Pubmed	Nuclear factor-κB binding motifs specify Toll-like receptor-induced gene repression through an inducible repressosome.	HDAC3 TLR4	1.31e-05	4	52	2	22891325
Pubmed	Loss of β2-spectrin prevents cardiomyocyte differentiation and heart development.	SPTBN1 SPTBN2	1.31e-05	4	52	2	24064296
Pubmed	TLR4, rather than TLR2, regulates wound healing through TGF-β and CCL5 expression.	TGFB1 TLR4	1.31e-05	4	52	2	24252748
Pubmed	Aberrant Toll receptor expression and endotoxin hypersensitivity in mice lacking a functional TGF-beta 1 signaling pathway.	TGFB1 TLR4	1.31e-05	4	52	2	15004187
Pubmed	SOCS3 promotes TLR4 response in macrophages by feedback inhibiting TGF-beta1/Smad3 signaling.	TGFB1 TLR4	1.31e-05	4	52	2	17920684
Pubmed	Transforming growth factor-β1 suppression of endotoxin-induced heme oxygenase-1 in macrophages involves activation of Smad2 and downregulation of Ets-2.	TGFB1 HMOX1	1.31e-05	4	52	2	21437904
Pubmed	The heme oxygenase-1/carbon monoxide pathway suppresses TLR4 signaling by regulating the interaction of TLR4 with caveolin-1.	TLR4 HMOX1	1.31e-05	4	52	2	19265160
Pubmed	The spectrin-based membrane skeleton stabilizes mouse megakaryocyte membrane systems and is essential for proplatelet and platelet formation.	SPTB SPTBN1	1.31e-05	4	52	2	21566095
Pubmed	Remarkable homology among the internal repeats of erythroid and nonerythroid spectrin.	SPTB SPTBN1	1.31e-05	4	52	2	3862089
Pubmed	β8 Integrin Expression and Activation of TGF-β by Intestinal Dendritic Cells Are Determined by Both Tissue Microenvironment and Cell Lineage.	TGFB1 CCR7	1.31e-05	4	52	2	27481847
Pubmed	Impaired TLR4 and HIF expression in cystic fibrosis bronchial epithelial cells downregulates hemeoxygenase-1 and alters iron homeostasis in vitro.	TLR4 HMOX1	1.31e-05	4	52	2	25239913
Pubmed	Loss of CD14 leads to disturbed epithelial-B cell crosstalk and impairment of the intestinal barrier after E. coli Nissle monoassociation.	TLR4 CCR7	1.31e-05	4	52	2	29335601
Pubmed	A Preliminary Study on Racial Differences in HMOX1, NFE2L2, and TGFβ1 Gene Polymorphisms and Radiation-Induced Late Normal Tissue Toxicity.	TGFB1 HMOX1	1.31e-05	4	52	2	26238954
Pubmed	Spectrin alpha II and beta II isoforms interact with high affinity at the tetramerization site.	SPTB SPTBN1	1.31e-05	4	52	2	12820899
Pubmed	Access to follicular dendritic cells is a pivotal step in murine chronic lymphocytic leukemia B-cell activation and proliferation.	CCR7 GPR183	1.31e-05	4	52	2	25252690
Pubmed	Voltage-Gated Sodium Channel Phosphorylation at Ser571 Regulates Late Current, Arrhythmia, and Cardiac Function In Vivo.	SPTBN4 SCN5A	1.31e-05	4	52	2	26187182
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	GTF2F2 MYO1D RBM12B POLR2B SPTBN1 SPTBN2 SUPT16H PDCD11 DDX55 DYNC1H1	1.46e-05	1257	52	10	36526897
Pubmed	The RNA polymerase II elongation complex.	GTF2F2 POLR2B SUPT16H	1.67e-05	33	52	3	12676794
Pubmed	TGF-β induces miR-30d down-regulation and podocyte injury through Smad2/3 and HDAC3-associated transcriptional repression.	TGFB1 HDAC3	2.19e-05	5	52	2	26432290
Pubmed	RANKL Impairs the TLR4 Pathway by Increasing TRAF6 and RANK Interaction in Macrophages.	TLR4 TNFRSF11B	2.19e-05	5	52	2	35463988
Pubmed	Regulation of B1 cell migration by signals through Toll-like receptors.	TLR4 CCR7	2.19e-05	5	52	2	17060475
GeneFamily	EF-hand domain containing\|Spectrins	SPTBN4 SPTB SPTBN1 SPTBN2	6.44e-10	7	39	4	1113
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	SPTBN4 SPTB SPTBN1 SPTBN2	9.85e-04	206	39	4	682
Coexpression	MITSIADES_RESPONSE_TO_APLIDIN_DN	NCAPG POLR2B SPTBN1 SUPT16H NUP188 TTC3	8.91e-06	250	51	6	M11318
ToppCell	E18.5-samps-Mesenchymal-Matrix_fibroblast-FB-1\|E18.5-samps / Age Group, Lineage, Cell class and subclass	KIF26B CCR7 GPR183 EXTL3 DISP1	1.18e-06	159	52	5	b4bc888e978b1b577721b891b0af6ba9a1607044
ToppCell	PBMC-Mild-cDC_9\|Mild / Compartment, Disease Groups and Clusters	CACNA1B NCAPG KIF26B TLR4 RNF213	2.41e-06	184	52	5	2e0c9a2c40c892a2d435eafb31f1f838de9baf15
ToppCell	Globus_pallidus-Neuronal\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	SPTBN4 CACNA1B SPTB SPTBN2 TTC3	2.82e-06	190	52	5	416de85d8841dac883faa6f5339b2fb461a09e82
ToppCell	5'-GW_trimst-2-LargeIntestine-Hematopoietic\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TLR4 RNF213 GPR183 HMOX1 DENND3	3.53e-06	199	52	5	5ceeed92f831d068ff4bb3994f420002338330e7
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW10-Mesenchymal-BMP_responsible_cell\|GW10 / Sample Type, Dataset, Time_group, and Cell type.	TGFB1 TLR4 CHD1L HMOX1 DENND3	3.62e-06	200	52	5	604a88633d4162337e394155c7346dbdef8b9f5a
ToppCell	3'_v3-GI_small-bowel-Lymphocytic_T_CD8-Trm/em_CD8\|GI_small-bowel / Manually curated celltypes from each tissue	TGFB1 SPTBN4 CCR7 GPR183	4.52e-05	169	52	4	17568e7aacfdcd96c469bae57d5ffad04954e9bd
ToppCell	droplet-Fat-SCAT-30m-Endothelial-nan\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GALR1 RBM12B KIF26B SPTBN1	4.95e-05	173	52	4	eb58b0189e71e38d4f4f1cf544a82cde8d1c86bc
ToppCell	BAL-Control-Myeloid-cDC-cDC-cDC_8\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SPTBN1 CCR7 GPR183 DENND3	5.65e-05	179	52	4	163f5430d72ea0c1b239ea5d21e53be536636d3d
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Hematopoietic-Myeloid-LYVE1+_Macrophage\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TGFB1 TLR4 HMOX1 DENND3	6.03e-05	182	52	4	de15a77b8d3527638bea5b04e0b2af03ac93bc18
ToppCell	Substantia_nigra-Neuronal\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	SPTBN4 CACNA1B SPTBN2 TTC3	6.56e-05	186	52	4	3f889083fcffe516388e9b03a5e23af2010ced33
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_pro-infl_II-D\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	TLR4 GPR183 HMOX1 TNFRSF11B	6.69e-05	187	52	4	2a7226adb4d15b92936603bdf05421c50b21f003
ToppCell	5'-GW_trimst-2-LargeIntestine-Hematopoietic-Myeloid-LYVE1+_Macrophage\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TLR4 GPR183 HMOX1 DENND3	6.83e-05	188	52	4	cb091912f9b627a78a8793a37df7f1de839f887f
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPTBN4 SPTB SPTBN2 TTC3	6.98e-05	189	52	4	f57200c93d39c9bce1adba0a6a1c178c028dd86b
ToppCell	BAL-Control-Myeloid-cDC-cDC-cDC_10\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	LIPG CCR7 GPR183 TNFRSF11B	7.41e-05	192	52	4	2c69f3f388b69fb1c1968c923cdbab90658883dd
ToppCell	BAL-Control-Myeloid-cDC-cDC-cDC_10\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	LIPG CCR7 GPR183 TNFRSF11B	7.41e-05	192	52	4	d5a7b546ebfb2e757dd9c64cb1b651f6ed0e0fc7
ToppCell	Entopeduncular-Neuronal\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	SPTBN4 CACNA1B SPTBN2 TTC3	7.41e-05	192	52	4	4c35e5c28a40b439044797ba1f06cb7c36b2a8de
ToppCell	control-Lymphoid-B_cell\|Lymphoid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	CCR7 GPR183 HMOX1 DENND3	7.72e-05	194	52	4	a5284adca931a78b1c4592925c4860853ebd24f1
ToppCell	3'-GW_trimst-2-SmallIntestine-Hematopoietic-Myeloid-LYVE1+_Macrophage\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TLR4 GPR183 HMOX1 DENND3	7.87e-05	195	52	4	028622b234551b185977fbee10c06851a45456a5
ToppCell	BAL-Control-cDC_10\|Control / Compartment, Disease Groups and Clusters	LIPG CCR7 GPR183 TNFRSF11B	8.03e-05	196	52	4	c32b7b7e6a4781c19c30c6e32d5563f82355deb0
ToppCell	3'-GW_trimst-2-LargeIntestine-Hematopoietic-Myeloid-LYVE1+_Macrophage\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TLR4 GPR183 HMOX1 DENND3	8.19e-05	197	52	4	b72dc02b76a782f08eb1350ce131b072caec1ab0
ToppCell	5'-GW_trimst-2-SmallIntestine-Hematopoietic-Myeloid-LYVE1+_Macrophage\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TLR4 GPR183 HMOX1 DENND3	8.35e-05	198	52	4	acb84681569651447d684aa3960f0510d7ff17e8
ToppCell	5'-GW_trimst-2-LargeIntestine-Hematopoietic-Myeloid\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TLR4 GPR183 HMOX1 DENND3	8.51e-05	199	52	4	f34c15df58fbdc6c90e30800e26fabbf828ad10b
ToppCell	wk_15-18-Hematologic-Myeloid-SPP1+_Mac\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	TLR4 GPR183 HMOX1 DENND3	8.51e-05	199	52	4	c7fc2ac1601346aac71e7620a8a440fde8d92dbd
ToppCell	wk_08-11-Hematologic-Myeloid-SPP1+_Mac\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	TGFB1 TLR4 GPR183 HMOX1	8.51e-05	199	52	4	d94cf750599366061066074e8007d707adf6fc5a
ToppCell	Sepsis-Leuk-UTI-Lymphocyte-T/NK-CD8+_Tcm\|Leuk-UTI / Disease, condition lineage and cell class	VPS13A CCR7 GPR183 TTC3	8.51e-05	199	52	4	6a1d84f61e1efaab541910926d6911122372659f
ToppCell	LPS_IL1RA-Endothelial-Endothelial\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	SPTBN1 RNF213 DISP1 DYNC1H1	8.68e-05	200	52	4	72ea9882a8ed26fa1534aeb6ba0d1897dccc20c5
ToppCell	LPS_IL1RA-Endothelial\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	SPTBN1 RNF213 DISP1 DYNC1H1	8.68e-05	200	52	4	5c092b2ecc081b5d04476c56333c338cd89ab984
ToppCell	LPS_IL1RA_TNF-Endothelial-Endothelial-Activated_Alv_Cap\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	SPTBN1 RNF213 DISP1 DYNC1H1	8.68e-05	200	52	4	89821a264e872ed53e08e9d3609d5cc5c314503e
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Activated_Alv_Cap\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	SPTBN1 RNF213 DISP1 DYNC1H1	8.68e-05	200	52	4	79e51afb57ca38aacebd0298e5e727b55c0cfff9
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW10-Mesenchymal\|GW10 / Sample Type, Dataset, Time_group, and Cell type.	TGFB1 TLR4 HMOX1 DENND3	8.68e-05	200	52	4	5c638c80661017c85f9390f1b398ac7728c8f001
ToppCell	Control_saline-Endothelial-Endothelial-Activated_Alv_Cap\|Control_saline / Treatment groups by lineage, cell group, cell type	SPTBN1 RNF213 DISP1 DYNC1H1	8.68e-05	200	52	4	be55cef682ba87250dad97689332c8820b3a7420
ToppCell	wk_08-11-Hematologic-Myeloid\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	TGFB1 TLR4 GPR183 HMOX1	8.68e-05	200	52	4	148e09e27e4a563bdd1fbe9a593cd938885cbb1b
Drug	ADPribulose	SPTBN4 SPTB SPTBN1 SPTBN2	1.70e-08	13	52	4	CID000197570
Drug	dimethyl adipimidate	SPTBN4 SPTB SPTBN1 SPTBN2	6.34e-07	30	52	4	CID000025738
Drug	phenylhydrazine	SPTBN4 SPTB SPTBN1 SPTBN2 HMOX1	1.22e-06	82	52	5	CID000007516
Drug	plakin	SPTBN4 SPTB SPTBN1 SPTBN2 DYNC1H1	1.22e-06	82	52	5	CID000018752
Drug	p-hydroxyphenylpyruvate	TGFB1 SPTBN4 SPTB SPTBN1 SPTBN2	2.05e-06	91	52	5	CID000000979
Drug	1,1'-azobis(N,N-dimethylformamide	SPTBN4 GALE SPTB SPTBN1 SPTBN2 HMOX1	2.69e-06	173	52	6	CID000004278
Drug	2-nitro-5-thiocyanobenzoic acid	SPTBN4 SPTB SPTBN1 SPTBN2	4.37e-06	48	52	4	CID000092266
Drug	MAPS	SPTBN4 SPTB SPTBN1 SPTBN2 SCN5A DYNC1H1	4.76e-06	191	52	6	CID000066161
Drug	PRODAN	SPTBN4 SPTBN1 SPTBN2	5.01e-06	15	52	3	CID000028127
Drug	6-propionyl-2-(dimethylamino)naphthalene	SPTB SPTBN1 SPTBN2	6.16e-06	16	52	3	CID000107729
Drug	dimyristoylphosphatidylcholine	SPTBN4 SPTB SPTBN1 SPTBN2	1.39e-05	64	52	4	CID000026197
Drug	cocoa butter	TGFB1 TLR4 HMOX1	1.68e-05	22	52	3	ctd:C052387
Drug	AC1L1HCM	SPTB SPTBN1 SPTBN2	1.68e-05	22	52	3	CID000004072
Drug	lipopolysaccharide, E. coli O26-B6	TGFB1 TLR4 CCR7 HMOX1 TNFRSF11B	2.00e-05	145	52	5	ctd:C433788
Drug	2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid ethyl amide	TGFB1 TLR4 HMOX1	2.20e-05	24	52	3	ctd:C518860
Drug	zinc mesoporphyrin	TGFB1 HMOX1	3.06e-05	4	52	2	ctd:C058069
Drug	aristolactam	TGFB1 CACNA1B	3.06e-05	4	52	2	CID000096710
Drug	AC1L1DDF	HDAC3 CCR7 HMOX1 TNFRSF11B	3.20e-05	79	52	4	CID000002302
Drug	Actinomycin C2	GALE SPTBN1	5.09e-05	5	52	2	CID000122716
Drug	ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate	TGFB1 TLR4 HMOX1	6.40e-05	34	52	3	ctd:C507035
Drug	baicalin	TGFB1 TLR4 HMOX1	7.61e-05	36	52	3	ctd:C038044
Drug	Titanium	TGFB1 TLR4 TNFRSF11B	7.61e-05	36	52	3	ctd:D014025
Drug	Fluphenazine dihydrochloride [146-56-5]; Up 200; 7.8uM; PC3; HT_HG-U133A	MYO1D LIPG SPTBN1 HMOX1 DENND3	8.01e-05	194	52	5	5880_UP
Drug	Lobelanidine hydrochloride [6112-86-3]; Down 200; 10.6uM; MCF7; HT_HG-U133A	MYO1D ADGRG2 SPTBN1 CHD1L MTERF4	8.61e-05	197	52	5	5500_DN
Drug	Sodium Cholate	TGFB1 TLR4 HMOX1	1.05e-04	40	52	3	ctd:D020358
Drug	myrrh resin	TGFB1 HMOX1	1.07e-04	7	52	2	ctd:C587573
Drug	di-2-pyridyl ketone	HMOX1 DYNC1H1	1.07e-04	7	52	2	CID000088065
Disease	spinocerebellar ataxia type 5 (implicated_via_orthology)	SPTBN4 SPTB SPTBN1 SPTBN2	7.29e-12	4	50	4	DOID:0050882 (implicated_via_orthology)
Disease	lung disease (biomarker_via_orthology)	TGFB1 TLR4 HMOX1	2.88e-05	35	50	3	DOID:850 (biomarker_via_orthology)
Disease	pathological myopia	GTF2F2 SPTBN1 TMEM68 PGBD2	3.82e-05	111	50	4	EFO_0004207
Disease	Inflammation	TGFB1 TLR4 HMOX1 TNFRSF11B	6.47e-05	127	50	4	C0021368
Disease	Fibrosis	TGFB1 TLR4 HMOX1	8.48e-05	50	50	3	C0016059
Disease	Cirrhosis	TGFB1 TLR4 HMOX1	8.48e-05	50	50	3	C1623038
Disease	Pneumonia	TGFB1 TLR4 HMOX1	1.07e-04	54	50	3	C0032285
Disease	Pneumonitis	TGFB1 TLR4 HMOX1	1.07e-04	54	50	3	C3714636
Disease	Lobar Pneumonia	TGFB1 TLR4 HMOX1	1.07e-04	54	50	3	C0032300
Disease	Experimental Lung Inflammation	TGFB1 TLR4 HMOX1	1.07e-04	54	50	3	C0887898
Disease	factor VIII deficiency (is_implicated_in)	TGFB1 HMOX1	1.53e-04	11	50	2	DOID:12134 (is_implicated_in)
Disease	pulmonary emphysema (is_implicated_in)	TGFB1 HMOX1	1.53e-04	11	50	2	DOID:9675 (is_implicated_in)
Disease	cystic fibrosis (is_marker_for)	TGFB1 TLR4 HMOX1	1.61e-04	62	50	3	DOID:1485 (is_marker_for)
Disease	chronic obstructive pulmonary disease (is_implicated_in)	TGFB1 TLR4 HMOX1	1.69e-04	63	50	3	DOID:3083 (is_implicated_in)
Disease	epilepsy (implicated_via_orthology)	KCNK18 CACNA1B SCN5A DYNC1H1	1.70e-04	163	50	4	DOID:1826 (implicated_via_orthology)
Disease	Centriacinar Emphysema	TGFB1 HMOX1	1.84e-04	12	50	2	C0221227
Disease	Panacinar Emphysema	TGFB1 HMOX1	1.84e-04	12	50	2	C0264393
Disease	Focal Emphysema	TGFB1 HMOX1	1.84e-04	12	50	2	C2350878
Disease	lung disease (implicated_via_orthology)	TLR4 HMOX1	2.17e-04	13	50	2	DOID:850 (implicated_via_orthology)
Disease	Anemia, Hemolytic, Acquired	SPTB HMOX1	2.17e-04	13	50	2	C0002879
Disease	Anemia, Hemolytic	SPTB HMOX1	2.17e-04	13	50	2	C0002878
Disease	Anemia, Microangiopathic	SPTB HMOX1	2.17e-04	13	50	2	C0002889
Disease	Microangiopathic hemolytic anemia	SPTB HMOX1	2.17e-04	13	50	2	C0221021
Disease	type 1 diabetes mellitus (is_marker_for)	TGFB1 HDAC3 TLR4	2.51e-04	72	50	3	DOID:9744 (is_marker_for)
Disease	sickle cell anemia (is_marker_for)	TGFB1 HMOX1	2.53e-04	14	50	2	DOID:10923 (is_marker_for)
Disease	Diabetic Asymmetric Polyneuropathy	TGFB1 TLR4	2.53e-04	14	50	2	C0393835
Disease	Diabetic Neuralgia	TGFB1 TLR4	2.53e-04	14	50	2	C0751074
Disease	Diabetic Neuropathies	TGFB1 TLR4	2.53e-04	14	50	2	C0011882
Disease	Asymmetric Diabetic Proximal Motor Neuropathy	TGFB1 TLR4	2.53e-04	14	50	2	C0271674
Disease	Symmetric Diabetic Proximal Motor Neuropathy	TGFB1 TLR4	2.53e-04	14	50	2	C0271673
Disease	Diabetic Mononeuropathy	TGFB1 TLR4	2.53e-04	14	50	2	C0271678
Disease	Diabetic Autonomic Neuropathy	TGFB1 TLR4	2.53e-04	14	50	2	C0271686
Disease	Diabetic Amyotrophy	TGFB1 TLR4	2.53e-04	14	50	2	C0271685
Disease	Diabetic Polyneuropathies	TGFB1 TLR4	2.53e-04	14	50	2	C0271680
Disease	migraine disorder	TGFB1 KIF26B RNF213 TRPM8 TMEM68	3.42e-04	357	50	5	MONDO_0005277
Disease	Sjogren's syndrome (implicated_via_orthology)	TGFB1 CCR7	3.77e-04	17	50	2	DOID:12894 (implicated_via_orthology)
Disease	Pulmonary Emphysema	TGFB1 HMOX1	3.77e-04	17	50	2	C0034067
Disease	Uremia	TGFB1 TNFRSF11B	3.77e-04	17	50	2	C0041948
Disease	carotid artery disease (is_marker_for)	TGFB1 TNFRSF11B	4.72e-04	19	50	2	DOID:3407 (is_marker_for)
Disease	inflammatory bowel disease (is_implicated_in)	TGFB1 ANO6	4.72e-04	19	50	2	DOID:0050589 (is_implicated_in)
Disease	Lung Injury	TLR4 HMOX1	5.79e-04	21	50	2	C0273115
Disease	Chronic Lung Injury	TLR4 HMOX1	5.79e-04	21	50	2	C2350344
Disease	impotence (biomarker_via_orthology)	TGFB1 HDAC3	6.36e-04	22	50	2	DOID:1875 (biomarker_via_orthology)
Disease	myocardial infarction (is_implicated_in)	TGFB1 LIPG TLR4	6.40e-04	99	50	3	DOID:5844 (is_implicated_in)
Disease	coronary artery disease (is_implicated_in)	LIPG TLR4 HMOX1	6.59e-04	100	50	3	DOID:3393 (is_implicated_in)
Disease	Acute Kidney Insufficiency	TGFB1 TLR4 HMOX1	6.79e-04	101	50	3	C1565662
Disease	Acute kidney injury	TGFB1 TLR4 HMOX1	6.79e-04	101	50	3	C2609414
Disease	Kidney Failure, Acute	TGFB1 TLR4 HMOX1	6.79e-04	101	50	3	C0022660
Disease	sciatic neuropathy (implicated_via_orthology)	TLR4 HMOX1	6.96e-04	23	50	2	DOID:11446 (implicated_via_orthology)
Disease	brain ischemia (biomarker_via_orthology)	TGFB1 SCN5A HMOX1	6.99e-04	102	50	3	DOID:2316 (biomarker_via_orthology)
Disease	Septicemia	TGFB1 TLR4	7.58e-04	24	50	2	C0036690
Disease	Sepsis	TGFB1 TLR4	7.58e-04	24	50	2	C0243026
Disease	Severe Sepsis	TGFB1 TLR4	7.58e-04	24	50	2	C1719672
Disease	Pyemia	TGFB1 TLR4	7.58e-04	24	50	2	C0034189
Disease	interstitial lung disease (is_marker_for)	TGFB1 HMOX1	8.23e-04	25	50	2	DOID:3082 (is_marker_for)
Disease	atopic dermatitis (is_implicated_in)	TGFB1 TLR4	8.91e-04	26	50	2	DOID:3310 (is_implicated_in)
Disease	anogenital venereal wart (is_marker_for)	TGFB1 TLR4	8.91e-04	26	50	2	DOID:11168 (is_marker_for)
Disease	acute kidney failure (implicated_via_orthology)	TLR4 HMOX1	9.61e-04	27	50	2	DOID:3021 (implicated_via_orthology)
Disease	Hyperplasia	TGFB1 HMOX1	1.03e-03	28	50	2	C0020507
Disease	pneumonia (is_marker_for)	TGFB1 CCR7	1.03e-03	28	50	2	DOID:552 (is_marker_for)
Disease	Developmental Academic Disorder	TLR4 HMOX1	1.11e-03	29	50	2	C1330966
Disease	Learning Disorders	TLR4 HMOX1	1.11e-03	29	50	2	C0023186
Disease	Learning Disturbance	TLR4 HMOX1	1.11e-03	29	50	2	C0751263
Disease	Adult Learning Disorders	TLR4 HMOX1	1.11e-03	29	50	2	C0751262
Disease	Learning Disabilities	TLR4 HMOX1	1.11e-03	29	50	2	C0751265
Disease	cardiovascular age measurement	SPTBN1 SCN5A	1.11e-03	29	50	2	EFO_0803380
Disease	pulmonary hypertension (is_implicated_in)	TGFB1 HMOX1	1.19e-03	30	50	2	DOID:6432 (is_implicated_in)
Disease	Adult T-Cell Lymphoma/Leukemia	CCR7 GPR183	1.27e-03	31	50	2	C0023493
Disease	asthma (is_marker_for)	TGFB1 TLR4 HMOX1	1.29e-03	126	50	3	DOID:2841 (is_marker_for)
Disease	hypertension (implicated_via_orthology)	TGFB1 LIPG HMOX1	1.35e-03	128	50	3	DOID:10763 (implicated_via_orthology)
Disease	Cholestasis, Extrahepatic	TGFB1 TLR4	1.35e-03	32	50	2	C0005398
Disease	pulmonary sarcoidosis (is_marker_for)	CCR7 HMOX1	1.35e-03	32	50	2	DOID:13406 (is_marker_for)
Disease	Behcet's disease (is_marker_for)	TLR4 HMOX1	1.44e-03	33	50	2	DOID:13241 (is_marker_for)
Disease	Chronic Obstructive Airway Disease	TGFB1 HMOX1	1.44e-03	33	50	2	C0024117
Disease	Chronic Airflow Obstruction	TGFB1 HMOX1	1.44e-03	33	50	2	C1527303
Disease	Global developmental delay	CACNA1B SPTBN2 SUPT16H	1.50e-03	133	50	3	C0557874
Disease	IGA Glomerulonephritis	TGFB1 GPR183	1.52e-03	34	50	2	C0017661
Disease	daytime rest measurement	KIF26B SPTB TLR4 DENND3	1.57e-03	295	50	4	EFO_0007828
Disease	type 2 diabetes mellitus (is_marker_for)	TGFB1 TLR4 TNFRSF11B	1.60e-03	136	50	3	DOID:9352 (is_marker_for)

Protein segments in the cluster

Peptide	Gene	Start	Entry
AFHMYLALVKVFNTY	ADGRG2	716	Q8IZP9
VHFCKLIFAIYKMSF	CCR7	126	P32248
YKQVLDTYMFHSFLK	DENND3	401	A2RUS2
VGKVYAALMIFDFYK	CACNA1B	1851	Q00975
YLFTLAYEKMHQFYK	DISP1	931	Q96F81
YAFVMFKTLKDYNTA	RBM12B	326	Q8IXT5
MEHVIYSVKFFISYA	ANO6	841	Q4KMQ2
YKNVMLFFAKGKFYH	KCNK18	366	Q7Z418
VFFTLHIYQYRMEKS	KIF26B	681	Q2KJY2
GMKAFVSYVQAYAKH	DDX55	421	Q8NHQ9
VLKDFYVHTVMTCYF	PCNX4	966	Q63HM2
VYHYQMKIHVFSYKN	LIPG	346	Q9Y5X9
YFYILFTIFTMKSKE	OR5K3	216	A6NET4
FYLTDRVMTVSFHKY	HDAC3	181	O15379
LTHFVRFFLMFYKEK	MGAT4D	301	A6NG13
QFLKLDYFQKLYMHS	PRAMEF12	261	O95522
LFKKYSFMAVIHFAG	GALE	76	Q14376
FICKFIHYFFTVSML	GALR1	106	P47211
RHKCINFFVKVYGYM	EXTL3	876	O43909
VVIYHGMSALQKKYY	CHD1L	276	Q86WJ1
IFLHEFSMAYTKYVG	MARF1	1506	Q9Y4F3
IYFTMESLKQIHFLY	DYNC1H1	3811	Q14204
GFKLVMASLYHIYVA	HMOX1	46	P09601
MLFSAFEKHQYYNLK	GTF2F2	186	P13984
EYKFQYAYFRMGIKH	MTERF4	231	Q7Z6M4
FIYFFACKGYKRKVM	GPR183	306	P32249
KVLLEYADKMFTYVF	SCN5A	1236	Q14524
FCETKKAYFLGYMVH	POLR2B	356	P30876
HLKNFDMVIVYKDYS	SUPT16H	851	Q9Y5B9
VTYYHYFSKMKALAV	SPTBN1	271	Q01082
EEFIHYLKYVMVVYK	NCAPG	46	Q9BPX3
YHIFFDKVFTSVKLM	PGBD2	346	Q6P3X8
HMKYSILPDYYKFIV	TMEM17	66	Q86X19
YYSLIKMVFAAAKAS	RNF213	2956	Q63HN8
MKFFFKRYLDYEKQH	PDCD11	1831	Q14690
FLHSFTMYKLYQKLF	TNFRSF11B	371	O00300
ENGRFAKYKYFTHVM	VPS13A	3066	Q96RL7
DFYYFMAKIFIHKGR	TMEM68	136	Q96MH6
YYHYFSKMKALAVEG	SPTBN2	276	O15020
KEMVFFLFAKHYLFC	TMEM247	191	A6NEH6
YDKFKQSTHSIYMFF	TGFB1	121	P01137
VLTFAYKHALVNKMY	TPP2	1181	P29144
IFFTEYKYHITKIVM	TTC3	196	P53804
SFLDKMSFYNELYKH	NUP188	466	Q5SRE5
YVVSFYHYFSKMKAL	SPTBN4	276	Q9H254
IITYVVAFYHYFSKM	SPTB	266	P11277
VAFYHYFSKMKVLAV	SPTB	271	P11277
GKFFYVKAYLMVHQK	ZNF25	236	P17030
QSKMYHCDIYVKVFY	ZNF429	141	Q86V71
IVFAYFYMVVKKCFK	TRPM8	1016	Q7Z2W7
VVAVLVYKFYFHLML	TLR4	646	O00206
MVADVFSHRFYKLYQ	USP11	541	P51784
TYEKFLHRYKMISEF	MYO1D	631	O94832