Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
MousePhenoincreased circulating type I collagen C-terminal telopeptide level

ITLN2 ITLN1

8.56e-056342MP:0031074
MousePhenodecreased circulating osteocalcin level

ITLN2 ITLN1

1.20e-047342MP:0030985
MousePhenodecreased osteoblast proliferation

ITLN2 ITLN1

1.20e-047342MP:0030439
MousePhenoincreased circulating interleukin-1 alpha level

ITLN2 ITLN1

1.59e-048342MP:0008638
MousePhenoabnormal circulating type I collagen C-terminal telopeptide level

ITLN2 ITLN1

1.59e-048342MP:0031072
MousePhenoincreased circulating interleukin-1 level

ITLN2 ITLN1 SECTM1

1.74e-0445343MP:0008591
DomainARM-type_fold

DNAAF5 CTIF VIRMA CIP2A MROH2B VPS35

1.18e-04339436IPR016024
DomainC2

RPGRIP1 PLCD1 C2CD2 SYT13

2.31e-04131434PF00168
DomainC2

RPGRIP1 PLCD1 C2CD2 SYT13

2.74e-04137434SM00239
DomainC2

RPGRIP1 PLCD1 C2CD2 SYT13

3.14e-04142434PS50004
Domain-

RPGRIP1 PLCD1 C2CD2 SYT13

3.67e-041484342.60.40.150
DomainATPase_dyneun-rel_AAA

MDN1 DNAH11

4.63e-0414432IPR011704
DomainAAA_5

MDN1 DNAH11

4.63e-0414432PF07728
DomainC2_dom

RPGRIP1 PLCD1 C2CD2 SYT13

5.42e-04164434IPR000008
DomainFibrinogen_C

ITLN2 ITLN1

1.75e-0327432PF00147
DomainFBG

ITLN2 ITLN1

2.02e-0329432SM00186
Domain-

ITLN2 ITLN1

2.16e-03304323.90.215.10
DomainFibrinogen_a/b/g_C_1

ITLN2 ITLN1

2.16e-0330432IPR014716
DomainFibrinogen_a/b/g_C_dom

ITLN2 ITLN1

2.46e-0332432IPR002181
DomainFIBRINOGEN_C_2

ITLN2 ITLN1

2.46e-0332432PS51406
DomainFIBRINOGEN_C_1

ITLN2 ITLN1

2.46e-0332432PS00514
DomainAAA+_ATPase

MDN1 ATAD2B DNAH11

4.42e-03144433IPR003593
DomainAAA

MDN1 ATAD2B DNAH11

4.42e-03144433SM00382
DomainHEAT_REPEAT

DNAAF5 MROH2B

1.13e-0270432PS50077
DomainP-loop_NTPase

GNL3L KIF3B MDN1 CHST4 ATAD2B DNAH11

1.25e-02848436IPR027417
Pubmed

Cloning of the novel gene intelectin, which is expressed in intestinal paneth cells in mice.

ITLN2 ITLN1

1.64e-0624529790983
Pubmed

Characterization of an intelectin-1 (Itln1) knockout mouse model.

ITLN2 ITLN1

1.64e-06245236072603
Pubmed

Intelectin1 ameliorates macrophage activation via inhibiting the nuclear factor kappa B pathway.

ITLN2 ITLN1

1.64e-06245234866068
Pubmed

VIRMA promotes the progression of head and neck squamous cell carcinoma by regulating UBR5 mRNA and m6A levels.

UBR5 VIRMA

1.64e-06245238577917
Pubmed

Recognition of microbial glycans by human intelectin-1.

ITLN2 ITLN1

1.64e-06245226148048
Pubmed

Comparative genomic and phylogenetic analyses of the intelectin gene family: implications for their origin and evolution.

ITLN2 ITLN1

1.64e-06245223643964
Pubmed

Human homologs of the Xenopus oocyte cortical granule lectin XL35.

ITLN2 ITLN1

1.64e-06245211181563
Pubmed

Omentin-1 inhibits the development of benign prostatic hyperplasia by attenuating local inflammation.

ITLN2 ITLN1

1.64e-06245238519941
Pubmed

Tetrahydroxystilbene glycoside improves endothelial dysfunction and hypertension in obese rats: The role of omentin-1.

ITLN2 ITLN1

1.64e-06245233647262
Pubmed

Omentin1 ameliorates myocardial ischemia-induced heart failure via SIRT3/FOXO3a-dependent mitochondrial dynamical homeostasis and mitophagy.

ITLN2 ITLN1

1.64e-06245236192726
Pubmed

Omentin-1 prevents inflammation-induced osteoporosis by downregulating the pro-inflammatory cytokines.

ITLN2 ITLN1

1.64e-06245229619269
Pubmed

Capture of heat-killed Mycobacterium bovis bacillus Calmette-Guérin by intelectin-1 deposited on cell surfaces.

ITLN2 ITLN1

1.64e-06245219179460
Pubmed

Omentin attenuates atherosclerotic lesion formation in apolipoprotein E-deficient mice.

ITLN2 ITLN1

1.64e-06245226714927
Pubmed

Innate BALB/c enteric epithelial responses to Trichinella spiralis: inducible expression of a novel goblet cell lectin, intelectin-2, and its natural deletion in C57BL/10 mice.

ITLN2 ITLN1

1.64e-06245215265922
Pubmed

Activation of ITLN-1 attenuates oxidative stress injury via activating SIRT1/PGC1-α signaling in neuroblastoma cells.

ITLN2 ITLN1

1.64e-06245237882238
Pubmed

Intelectin contributes to allergen-induced IL-25, IL-33, and TSLP expression and type 2 response in asthma and atopic dermatitis.

ITLN2 ITLN1

1.64e-06245228224996
Pubmed

ITLN1 inhibits tumor neovascularization and myeloid derived suppressor cells accumulation in colorectal carcinoma.

ITLN2 ITLN1

1.64e-06245234363021
Pubmed

Omentin prevents myocardial ischemic injury through AMP-activated protein kinase- and Akt-dependent mechanisms.

ITLN2 ITLN1

1.64e-06245224768874
Pubmed

The potential role of omentin-1 in obesity-related metabolic dysfunction-associated steatotic liver disease: evidence from translational studies.

ITLN2 ITLN1

1.64e-06245238082368
Pubmed

Methylation of human eukaryotic elongation factor alpha (eEF1A) by a member of a novel protein lysine methyltransferase family modulates mRNA translation.

EEF1AKMT4-ECE2 EEF1AKMT4

4.91e-06345228520920
Pubmed

Intelectin: a novel lipid raft-associated protein in the enterocyte brush border.

ITLN2 ITLN1

4.91e-06345216866365
Pubmed

Ontogenic changes in lactoferrin receptor and DMT1 in mouse small intestine: implications for iron absorption during early life.

ITLN2 ITLN1

4.91e-06345216936804
Pubmed

Baculovirus expression of mouse lactoferrin receptor and tissue distribution in the mouse.

ITLN2 ITLN1

4.91e-06345215222482
Pubmed

miR-584 mediates post-transcriptional expression of lactoferrin receptor in Caco-2 cells and in mouse small intestine during the perinatal period.

ITLN2 ITLN1

4.91e-06345219665576
Pubmed

Omentin-1 drives cardiomyocyte cell cycle arrest and metabolic maturation by interacting with BMP7.

ITLN2 ITLN1

4.91e-06345237344704
Pubmed

Intelectin-1 binds and alters the localization of the mucus barrier-modifying bacterium Akkermansia muciniphila.

ITLN2 ITLN1

4.91e-06345236413219
Pubmed

Nippostrongylus brasiliensis: identification of intelectin-1 and -2 as Stat6-dependent genes expressed in lung and intestine during infection.

ITLN2 ITLN1

9.81e-06445217420014
Pubmed

Molecular motors: the driving force behind mammalian left-right development.

KIF3B DNAH11

9.81e-06445210652513
Pubmed

Intelectin is required for IL-13-induced monocyte chemotactic protein-1 and -3 expression in lung epithelial cells and promotes allergic airway inflammation.

ITLN2 ITLN1

9.81e-06445219965981
Pubmed

Omentin protects against LPS-induced ARDS through suppressing pulmonary inflammation and promoting endothelial barrier via an Akt/eNOS-dependent mechanism.

ITLN2 ITLN1

9.81e-06445227607575
Pubmed

Deficiency of Omentin-1 leads to delayed fracture healing through excessive inflammation and reduced CD31hiEmcnhi vessels.

ITLN2 ITLN1

9.81e-06445234174367
Pubmed

Left-right development: the roles of nodal cilia.

KIF3B DNAH11

9.81e-06445210704402
Pubmed

CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.

DNAAF5 GNL3L MDN1 DCAF5 CIP2A VPS35 ATG2B

1.20e-0560645736538041
Pubmed

Strain-specific copy number variation in the intelectin locus on the 129 mouse chromosome 1.

ITLN2 ITLN1

1.63e-05545221324158
Pubmed

Identification of a novel, putative Rho-specific GDP/GTP exchange factor and a RhoA-binding protein: control of neuronal morphology.

ARHGEF28 MPRIP

1.63e-0554529199174
Pubmed

CIP2A Interacts with TopBP1 and Drives Basal-Like Breast Cancer Tumorigenesis.

UBR5 CIP2A

4.56e-05845234145035
Pubmed

Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family.

DNAAF5 ARHGEF28 EYA3 UBR5 DCAF5 CIP2A ATG2B

1.80e-0493145727432908
Pubmed

USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.

MDN1 VIRMA VPS35 MPRIP

2.40e-0423445436243803
Pubmed

Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.

KIF3B MDN1 MMP17 DCAF5 CIP2A DNAH11

2.50e-0468945636543142
Pubmed

Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

KIF3B MDN1 MICU2

3.36e-041044539205841
Pubmed

FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.

GNL3L MDN1 ANO3 HPR VPS35

4.45e-0449745536774506
Pubmed

DNA cloning using in vitro site-specific recombination.

GRM1 MAT2B SYT13 CIP2A VPS35 ENTPD6

5.30e-0479445611076863
Pubmed

Primary Ciliary Dyskinesia

DNAAF5 DNAH11

7.92e-043245220301301
Pubmed

RAD21 cooperates with pluripotency transcription factors in the maintenance of embryonic stem cell identity.

GNL3L MDN1 VIRMA

9.04e-0414645321589869
Pubmed

Protein kinase DYRK2 is a scaffold that facilitates assembly of an E3 ligase.

UBR5 DCAF5

9.48e-043545219287380
InteractionTUBB interactions

CTIF MDN1 GRM1 MICU2 UBR5 MAT2B VIRMA ITLN1 CIP2A

2.01e-05735439int:TUBB
InteractionZNF891 interactions

VIRMA ZNF891

2.66e-054432int:ZNF891
InteractionANO2 interactions

VIRMA ANO3

4.43e-055432int:ANO2
InteractionCLEC16A interactions

DNAAF5 GNL3L MDN1 VIRMA DCAF5 CIP2A VPS35 ATG2B

4.75e-05629438int:CLEC16A
InteractionCSPP1 interactions

RPGRIP1 UBR5 CIP2A VPS35

5.17e-0596434int:CSPP1
ToppCellASK440-Epithelial-Transformed_epithelium|ASK440 / Donor, Lineage and Cell class of Lung cells from Dropseq

DNAAF5 KLHL35 PDE4C ANO3 ITLN1

9.30e-07172465df3800bcd9777d02900eba0cfc26ab73de8a1d95
ToppCellHippocampus-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)|Hippocampus / BrainAtlas - Mouse McCarroll V32

MAT2B ANO3 DKK2 TUSC3

2.29e-0516146466554f59eaea4ba55a6c6724f9368e24e99c91e9
ToppCell368C-Fibroblasts-Fibroblast-J_(Lipofibroblast)-|368C / Donor, Lineage, Cell class and subclass (all cells)

ITLN2 ITLN1 HPR CHST4

2.58e-051664644d63c758d46e73311b864148c646bf081498dee7
ToppCell368C-Fibroblasts-Fibroblast-J_(Lipofibroblast)|368C / Donor, Lineage, Cell class and subclass (all cells)

ITLN2 ITLN1 HPR CHST4

2.58e-051664644160ccf9291072a6e2782f9ad141bc9a9747f3ad
ToppCell368C-Fibroblasts-Fibroblast-J_(Lipofibroblast)|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

ITLN2 ITLN1 HPR CHST4

2.71e-05168464e870d2e69316406f45112ed0bf324b24f902a99e
ToppCell368C-Fibroblasts-Fibroblast-J_(Lipofibroblast)-|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

ITLN2 ITLN1 HPR CHST4

2.71e-05168464403aba73a0f9ffb32252288d075fad8a588ca440
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_D_(IT_RORB_THEMIS_LINC00507)_6|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ARHGEF28 GRM1 ANO3 DKK2

3.25e-051764640710689e66deba179b0a8038cdd56b4834984f12
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_D_(IT_RORB_THEMIS_LINC00507)_6-Exc_L6_THEMIS_LINC00343|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ARHGEF28 GRM1 ANO3 DKK2

3.32e-05177464921783ed0fe20294d2f384d9136924b679df01bb
ToppCellASK440-Epithelial-Transformed_epithelium|Epithelial / Donor, Lineage and Cell class of Lung cells from Dropseq

DNAAF5 KLHL35 ANO3 ITLN1

3.39e-0517846486f1741636ed3e85bb4a65f84949b718fc38c290
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_D_(IT_RORB_THEMIS_LINC00507)_6-Exc_L6_THEMIS_LINC00343|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ARHGEF28 GRM1 ANO3 DKK2

3.39e-051784646f61490d79cd1727ed2d5cc673823dd4efdafac1
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_D_(IT_RORB_THEMIS_LINC00507)_6|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ARHGEF28 GRM1 ANO3 DKK2

3.47e-05179464445eeb0356d9fd894aa33dd9f45d893b21424149
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_D_(IT_RORB_THEMIS_LINC00507)_6|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ARHGEF28 GRM1 ANO3 DKK2

3.47e-051794641ac79c82c52fa95bb4e170ab20fec0f648db2134
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_D_(IT_RORB_THEMIS_LINC00507)_6-Exc_L6_THEMIS_LINC00343|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ARHGEF28 GRM1 ANO3 DKK2

3.47e-05179464065a50952e8703fa07767beb6b73a090bf378ca6
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_D_(IT_RORB_THEMIS_LINC00507)_6-Exc_L6_THEMIS_LINC00343|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ARHGEF28 GRM1 ANO3 DKK2

3.62e-051814649de2f2cc5f02e0ca599c9e0d2cb1e1e4b5aac112
ToppCell5'-Adult-LymphNode-Endothelial-blood_vessel_EC-Mature_arterial_EC|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

F8 HPR DKK2 TUSC3

3.70e-051824640639011cdd1c437ea8b7230896a4e6e5d7244ac2
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_D_(IT_RORB_THEMIS_LINC00507)_6|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ARHGEF28 GRM1 ANO3 DKK2

3.70e-0518246431efc06d6b073e8e341648207093e5f33c6f9183
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_D_(IT_RORB_THEMIS_LINC00507)_6|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ARHGEF28 GRM1 ANO3 DKK2

3.86e-05184464ca35a3d2b536c8b2bf5c4d635605e5a3ae94a428
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_D_(IT_RORB_THEMIS_LINC00507)_6-Exc_L6_THEMIS_EGR3|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ARHGEF28 GRM1 ANO3 DKK2

4.03e-0518646477b09af860183606a1775eba921e2071e4a7dd4e
DrugPirenperone [ 75444-65-4]; Up 200; 10.2uM; MCF7; HT_HG-U133A

PKNOX2 MST1R CTIF PLCD1 GRM1 SYT13

2.15e-061984465639_UP
Diseaselevel of intelectin-1 in blood serum

ITLN2 ITLN1

2.07e-062432OBA_2044678
Diseasecesarean section, anxiety

MAT2B DKK2

5.78e-058432EFO_0005230, EFO_0009636
Diseaselow density lipoprotein cholesterol measurement, physical activity

C2CD2 HPR DNAH11

1.24e-0466433EFO_0003940, EFO_0004611
Diseasecystatin-F measurement

KIF3B ENTPD6

2.46e-0416432EFO_0008104
DiseaseSLAM family member 7 measurement

ITLN2 ITLN1

2.78e-0417432EFO_0008287
Diseasebrain age measurement

EEF1AKMT4-ECE2 EEF1AKMT4

3.88e-0420432EFO_0010602
Diseasehaptoglobin measurement

HPR CHST4

4.28e-0421432EFO_0004640
Diseaseage of onset of Alzheimer disease

ANO3 TUSC3

1.06e-0333432OBA_2001000
DiseasePrimary ciliary dyskinesia

DNAAF5 DNAH11

1.27e-0336432cv:C0008780
DiseasePrimary Ciliary Dyskinesia

DNAAF5 DNAH11

2.15e-0347432C4551720
DiseaseDNA methylation

MDN1 ANO3 MROH2B TUSC3 DNAH11

2.56e-03656435GO_0006306
Diseaseapolipoprotein B measurement

PDE4C HPR CHST4 ENTPD6 DNAH11

2.68e-03663435EFO_0004615
DiseaseIGFBP-3 measurement

PKNOX2 MPRIP

2.83e-0354432EFO_0004626

Protein segments in the cluster

PeptideGeneStartEntry
LKNPRRQIAMWHQLH

SYT13

411

Q7L8C5
QNRRWHHGNMKHPPG

CTIF

246

O43310
RNNRKVNIPHWQMAH

AIFM3

476

Q96NN9
QSPALRDRHWHQLMK

DNAH11

1401

Q96DT5
GWQNLGRPHTKMSHI

DKK2

161

Q9UBU2
QHRMLPSGLSWHEQI

ATG2B

1201

Q96BY7
QQQRRKSGQPVHHEW

ANO3

966

Q9BYT9
KQHNMPFWRITNHGD

EYA3

546

Q99504
MRAQQSLLGHWKHGR

ARHGEF28

1521

Q8N1W1
HVPNKSPMQHWRNSS

ITLN1

151

Q8WWA0
AWARSKNPQEMLHLH

MDN1

4146

Q9NU22
RRNWIQTIMKHVHPT

MPRIP

471

Q6WCQ1
ANMDHWQQRFPTHVK

MAT2B

211

Q9NZL9
PWQAKMVSHHNLTTG

HPR

116

P00739
AFRHKQRNPMDVWHN

ATAD2B

1111

Q9ULI0
GRHSMTRAPKHLWRQ

PDE4C

21

Q08493
WHMEQAIHSRVKPIQ

DCAF5

81

Q96JK2
RIHPQSWVHQIALRM

F8

2326

P00451
HSGSMDQRQKLQHWI

PLCD1

131

P51178
AMQARHAHVPQLRWE

EEF1AKMT4-ECE2

96

P0DPD8
RRRHQQKDPGMSQSH

C2CD2

636

Q9Y426
NKSPMQHWRNSALLR

ITLN2

166

Q8WWU7
PLMQTISHQHWKVRV

DNAAF5

211

Q86Y56
GQVPKGQHMWHRLSV

GRM1

901

Q13255
AMRKTALWHTGHLQP

FAM27D1

61

Q5T7N8
KHPDVVQRQHMLWTG

POLR3E

411

Q9NVU0
PKHATNIMRSWLFQH

PKNOX2

296

Q96KN3
KAGWRQRLSMHQRPQ

RPGRIP1

106

Q96KN7
FVMMHWKQRHSRSRP

TCEAL8

96

Q8IYN2
QHGPWQTRMRKISNH

ENTPD6

21

O75354
RHLVSLQPAQMHRFW

MMP17

361

Q9ULZ9
TNPNRHQMGWAKRNV

GNL3L

491

Q9NVN8
HQMGWAKRNVDHRPK

GNL3L

496

Q9NVN8
LKNRMHRGLWVPQHQ

MICU2

391

Q8IYU8
CPWSHRRHVMQQGEQ

MROH2B

1181

Q7Z745
AMQARHAHVPQLRWE

EEF1AKMT4

96

P0DPD7
TEHIPRKMPWQSSNH

CIP2A

561

Q8TCG1
HLQTWVHNITRGKGM

CHST4

301

Q8NCG5
QMWNHIRGPPYAHKN

TUSC3

246

Q13454
MWHLVGHQRNNRQVT

SECTM1

116

Q8WVN6
HWKLHPITRLENQQM

KIF3B

611

O15066
NKLWVRMQHQGHSRD

VPS35

191

Q96QK1
PWRLHVNMGTTLHRV

VIRMA

986

Q69YN4
VQQHRHARLPVKWMA

MST1R

1241

Q04912
IRKQHKIPGGHWRQM

ZNF891

161

A8MT65
PRSMQWAVRNTQHQR

UBR5

1711

O95071
HKGRWRHKMAVVQGQ

KLHL35

381

Q6PF15