Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	Homeobox_CS	HOXB2 RHOXF2B RHOXF2	3.56e-03	186	31	3	IPR017970
Domain	Homeobox	HOXB2 RHOXF2B RHOXF2	6.74e-03	234	31	3	PF00046
Domain	PHD	KDM7A KMT2D	6.86e-03	75	31	2	PF00628
Domain	HOMEOBOX_1	HOXB2 RHOXF2B RHOXF2	6.90e-03	236	31	3	PS00027
Domain	HOX	HOXB2 RHOXF2B RHOXF2	6.98e-03	237	31	3	SM00389
Domain	Homeobox_dom	HOXB2 RHOXF2B RHOXF2	7.14e-03	239	31	3	IPR001356
Domain	HOMEOBOX_2	HOXB2 RHOXF2B RHOXF2	7.14e-03	239	31	3	PS50071
Domain	Znf_PHD-finger	KDM7A KMT2D	7.59e-03	79	31	2	IPR019787
Domain	PHD	KDM7A KMT2D	9.54e-03	89	31	2	SM00249
Domain	Znf_PHD	KDM7A KMT2D	9.96e-03	91	31	2	IPR001965
Domain	ZF_PHD_2	KDM7A KMT2D	1.08e-02	95	31	2	PS50016
Domain	ZF_PHD_1	KDM7A KMT2D	1.10e-02	96	31	2	PS01359
Domain	-	HOXB2 RHOXF2B RHOXF2	1.13e-02	283	31	3	1.10.10.60
Pubmed	Cloning and characterization of Ehox, a novel homeobox gene essential for embryonic stem cell differentiation.	RHOXF2B RHOXF2	7.69e-07	2	31	2	12087094
Pubmed	Rhox homeobox gene cluster: recent duplication of three family members.	RHOXF2B RHOXF2	7.69e-07	2	31	2	16496311
Pubmed	Identification of a tandem duplicated array in the Rhox alpha locus on mouse chromosome X.	RHOXF2B RHOXF2	7.69e-07	2	31	2	16465597
Pubmed	Cloning and characterization of the 5'-flanking region of the Ehox gene.	RHOXF2B RHOXF2	7.69e-07	2	31	2	16414020
Pubmed	The RHOX5 homeodomain protein mediates transcriptional repression of the netrin-1 receptor gene Unc5c.	RHOXF2B RHOXF2	2.31e-06	3	31	2	18077458
Pubmed	The rhox homeobox gene family shows sexually dimorphic and dynamic expression during mouse embryonic gonad development.	RHOXF2B RHOXF2	2.31e-06	3	31	2	18562707
Pubmed	SNIP1 Recruits TET2 to Regulate c-MYC Target Genes and Cellular DNA Damage Response.	XRN2 CHERP RRP12 STAT5A HLF	3.20e-06	259	31	5	30404004
Pubmed	Rhox: a new homeobox gene cluster.	RHOXF2B RHOXF2	4.61e-06	4	31	2	15707895
Pubmed	Expression of a novel homeobox gene Ehox in trophoblast stem cells and pharyngeal pouch endoderm.	RHOXF2B RHOXF2	7.68e-06	5	31	2	14648851
Pubmed	Cloning of the gene for spinocerebellar ataxia 2 reveals a locus with high sensitivity to expanded CAG/glutamine repeats.	KMT2D CHERP	1.15e-05	6	31	2	8896557
Pubmed	A census of human transcription factors: function, expression and evolution.	HOXB2 KMT2D NEUROD2 ZNF593 RHOXF2 STAT5A HLF	1.23e-05	908	31	7	19274049
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	XRN2 CHERP DYNC1H1 RRP12 MCM3AP IQGAP1	2.11e-05	653	31	6	22586326
Pubmed	A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.	RHOXF2B NEUROD2 ZNF593 RHOXF2 RNF146 STAT5A	3.35e-05	709	31	6	22988430
Pubmed	Low BACH2 Expression Predicts Adverse Outcome in Chronic Lymphocytic Leukaemia.	KDM7A DYNC1H1 ETF1	3.37e-05	70	31	3	35008187
Pubmed	Cell-cell adhesion defects in Mrj mutant trophoblast cells are associated with failure to pattern the chorion during early placental development.	RHOXF2B RHOXF2	3.44e-05	10	31	2	21972064
Pubmed	A major X-linked locus affects kidney function in mice.	RHOXF2B RHOXF2	5.05e-05	12	31	2	23011808
Pubmed	Deletion of the Syncytin A receptor Ly6e impairs syncytiotrophoblast fusion and placental morphogenesis causing embryonic lethality in mice.	RHOXF2B RHOXF2	5.05e-05	12	31	2	29500366
Pubmed	Poly(ADP-ribosyl)ation of BRD7 by PARP1 confers resistance to DNA-damaging chemotherapeutic agents.	ASCC2 XRN2 RNF146 RRP12 IQGAP1	6.57e-05	486	31	5	30940648
Pubmed	Quantitative trait loci for periosteal circumference (PC): identification of single loci and epistatic effects in F2 MRL/SJL mice.	HOXB2 STAT5A	6.95e-05	14	31	2	12753872
Pubmed	Tissue-Specific Regulation of the Wnt/β-Catenin Pathway by PAGE4 Inhibition of Tankyrase.	XRN2 CHERP DYNC1H1 RNF146	7.72e-05	256	31	4	32698014
Pubmed	Functional proteomic analysis of human nucleolus.	XRN2 ZNF593 RRP12	1.16e-04	106	31	3	12429849
Pubmed	ARHGEF18/p114RhoGEF Coordinates PKA/CREB Signaling and Actomyosin Remodeling to Promote Trophoblast Cell-Cell Fusion During Placenta Morphogenesis.	RHOXF2B RHOXF2	1.17e-04	18	31	2	33842485
Pubmed	Targeted inactivation of MLL3 histone H3-Lys-4 methyltransferase activity in the mouse reveals vital roles for MLL3 in adipogenesis.	ASCC2 KMT2D	1.45e-04	20	31	2	19047629
Pubmed	Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition.	KDM7A KMT2D	1.60e-04	21	31	2	27626377
Pubmed	TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1.	XRN2 CHERP ZNF593 DYNC1H1 RRP12 IQGAP1	1.67e-04	949	31	6	36574265
Pubmed	CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.	ASCC2 XRN2 CHERP RRP12 IQGAP1	1.83e-04	605	31	5	28977666
Pubmed	Lupus nephritis susceptibility loci in women with systemic lupus erythematosus.	XRN2 ARMH4	1.92e-04	23	31	2	24925725
Pubmed	MYC multimers shield stalled replication forks from RNA polymerase.	AEN XRN2 CHERP RRP12 IQGAP1 ETF1	2.09e-04	989	31	6	36424410
Pubmed	DNA methylation regulates long-range gene silencing of an X-linked homeobox gene cluster in a lineage-specific manner.	RHOXF2B RHOXF2	2.10e-04	24	31	2	17182866
Pubmed	The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.	XRN2 CHERP DYNC1H1 IQGAP1 ETF1	2.34e-04	638	31	5	33239621
Pubmed	SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation-Phosphorylation Cross-talk.	XRN2 CHERP RRP12 MCM3AP IQGAP1	2.64e-04	655	31	5	35819319
Pubmed	Maternal DNA Methylation Regulates Early Trophoblast Development.	RHOXF2B RHOXF2	2.86e-04	28	31	2	26812015
Pubmed	Specification of jaw identity by the Hand2 transcription factor.	RHOXF2B RHOXF2	2.86e-04	28	31	2	27329940
Pubmed	Identification of different proteins binding to Na, K-ATPase α1 in LPS-induced ARDS cell model by proteomic analysis.	DYNC1H1 RRP12 IQGAP1	2.87e-04	144	31	3	35681168
Pubmed	Identification of a USP9X Substrate NFX1-123 by SILAC-Based Quantitative Proteomics.	ASCC2 XRN2 RRP12 IQGAP1	3.64e-04	384	31	4	31059266
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	XRN2 KMT2D LIN37 DYNC1H1 IQGAP1 ETF1	3.74e-04	1103	31	6	34189442
Pubmed	Nucleolar proteome dynamics.	XRN2 DYNC1H1 RRP12 ETF1	5.05e-04	419	31	4	15635413
Pubmed	Lysine demethylase 7a regulates murine anterior-posterior development by modulating the transcription of Hox gene cluster.	HOXB2 KDM7A	5.58e-04	39	31	2	33257809
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	ASCC2 XRN2 DYNC1H1 RRP12 IQGAP1 ETF1	7.46e-04	1257	31	6	36526897
Pubmed	ABCE1 is a highly conserved RNA silencing suppressor.	RRP12 IQGAP1 ETF1	7.92e-04	204	31	3	25659154
Pubmed	Charcot-Marie-Tooth Hereditary Neuropathy Overview	DYNC1H1 MCM3AP	8.45e-04	48	31	2	20301532
Cytoband	14q23.1	PRKCH ARMH4	4.68e-04	47	31	2	14q23.1
Cytoband	15q26.1	AEN IQGAP1	6.18e-04	54	31	2	15q26.1
Cytoband	Xq24	RHOXF2B RHOXF2	8.67e-04	64	31	2	Xq24
Cytoband	Ensembl 112 genes in cytogenetic band chrXq24	RHOXF2B RHOXF2	1.38e-03	81	31	2	chrXq24
Cytoband	17q11.2	CORO6 STAT5A	2.53e-03	110	31	2	17q11.2
Cytoband	Ensembl 112 genes in cytogenetic band chr14q23	PRKCH ARMH4	3.51e-03	130	31	2	chr14q23
GeneFamily	PHD finger proteins	KDM7A KMT2D	2.81e-03	90	16	2	88
GeneFamily	PRD class homeoboxes and pseudogenes	RHOXF2B RHOXF2	2.93e-03	92	16	2	521
Coexpression	HEIDENBLAD_AMPLICON_8Q24_UP	AEN DYNC1H1 HLF	1.55e-05	41	31	3	M18260
Coexpression	EPPERT_CE_HSC_LSC	HOXB2 PRKCH HLF	1.55e-05	41	31	3	M19233
Disease	Charcot-Marie-Tooth disease	DYNC1H1 MCM3AP	6.79e-04	42	27	2	cv:C0007959
Disease	mean corpuscular hemoglobin concentration	ASCC2 XRN2 NEUROD2 PPP1R16A ARMH4	2.96e-03	1105	27	5	EFO_0004528
Disease	obsolete_red blood cell distribution width	XRN2 NEUROD2 RNF146 IQGAP1 ARMH4	6.86e-03	1347	27	5	EFO_0005192
Disease	Mammary Carcinoma, Animal	NSMF STAT5A	7.46e-03	142	27	2	C1257925
Disease	stomach cancer (is_marker_for)	KMT2D HLF	7.46e-03	142	27	2	DOID:10534 (is_marker_for)
Disease	Animal Mammary Neoplasms	NSMF STAT5A	7.46e-03	142	27	2	C0024667
Disease	rheumatoid arthritis	PRKCH NEUROD2 IQGAP1	8.44e-03	462	27	3	EFO_0000685
Disease	Mammary Neoplasms, Experimental	NSMF STAT5A	8.83e-03	155	27	2	C0024668
Disease	prostate cancer (is_marker_for)	KMT2D STAT5A	8.94e-03	156	27	2	DOID:10283 (is_marker_for)
Disease	Carcinomatosis	NSMF STAT5A	9.72e-03	163	27	2	C0205699
Disease	Carcinoma, Spindle-Cell	NSMF STAT5A	9.72e-03	163	27	2	C0205697
Disease	Undifferentiated carcinoma	NSMF STAT5A	9.72e-03	163	27	2	C0205698
Disease	Anaplastic carcinoma	NSMF STAT5A	9.72e-03	163	27	2	C0205696
Disease	Carcinoma	NSMF STAT5A	9.84e-03	164	27	2	C0007097

Protein segments in the cluster

Peptide	Gene	Start	Entry
KRRSRQHQRFMARKA	AEN	31	Q8WTP8
TRANHNRRTMADRKR	ASCC2	736	Q9H1I8
KVMNRRRRNGFKRHK	ARMH4	736	Q86TY3
RQKRLQAMQKRRLHR	CCDC74A	361	Q96AQ1
ARMHQARKRYRDRLQ	IQGAP1	816	P46940
HSRRKMRKLRDHNVR	KDM7A	506	Q6ZMT4
SARFPHQRRKKRREM	LIN37	66	Q96GY3
RLRRLRNKTAHQMKV	MCM3AP	1311	O60318
RKRRQRQLHPKMRTR	NUPR2	81	A6NF83
NFRKHLRMVGSRRVK	NSMF	261	Q6X4W1
RRRKNNMAAKRSRDA	HLF	231	Q16534
FQNRRMKHKRQTQHR	HOXB2	191	P14652
FFRAKMRARRRKGQE	CHERP	716	Q8IWX8
MSRRVVRQSKFRHVF	CORO6	1	Q6QEF8
HRKLQARLDQMRKFR	DYNC1H1	456	Q14204
MSSHRRKAKGRNRRS	FMR1NB	1	Q8N0W7
RKAKGRNRRSHRAMR	FMR1NB	6	Q8N0W7
RYRRKRHISVRDMNA	R3HDML	51	Q9H3Y0
RLHSKDQRKRMRAFQ	RTL5	356	Q5HYW3
QLQQRSLMRRHRKKK	LRRTM3	451	Q86VH5
RMSTQERLKHAQKRR	PPP1R16A	16	Q96I34
NMVQYRRNEHGRRRK	RNF146	151	Q9NTX7
RAKWRRHQRALMARN	RHOXF2B	186	P0C7M4
MRRHFRMKLRNLFTK	RRP12	996	Q5JTH9
FRNMSLKRIKRADRR	STAT5A	416	P42229
APRAKMNQQRSRRFR	XRN2	106	Q9H0D6
HKNMRVLSRTSKFRR	nan	306	A8MX80
RAKWRRHQRALMARN	RHOXF2	186	Q9BQY4
RAHSLARQMKAKRRR	ZNF593	11	O00488
RKNMRVLSRTSKFRR	nan	276	A8MV72
RKNMRVLSRISKFRR	nan	306	Q8N9G6
RKNMRVLSRTSKFRR	nan	306	A8MUA0
SALRFARLRMEKRHN	ETF1	186	P62495
RNLTMSPLHKRRQRR	KMT2D	1601	O14686
FKHFTRKRQRAMRRR	PRKCH	151	P24723
RKRQRAMRRRVHQIN	PRKCH	156	P24723
LRRQKANARERNRMH	NEUROD2	121	Q15784