Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	1-phosphatidylinositol-5-phosphate 4-kinase activity	PIP4K2B PIP4K2A	4.89e-06	3	26	2	GO:0016309
GeneOntologyMolecularFunction	1-phosphatidylinositol-4-phosphate 5-kinase activity	PIP4K2B PIP4K2A	5.84e-05	9	26	2	GO:0016308
GeneOntologyMolecularFunction	phosphatidylinositol kinase activity	PIP4K2B PIP4K2A	5.20e-04	26	26	2	GO:0052742
GeneOntologyMolecularFunction	calcium-activated cation channel activity	KCNN2 TRPC3	5.61e-04	27	26	2	GO:0005227
GeneOntologyMolecularFunction	monoatomic ion-gated channel activity	KCNN2 TRPC3	7.41e-04	31	26	2	GO:0022839
GeneOntologyMolecularFunction	microfilament motor activity	MYH2 MYH8	1.11e-03	38	26	2	GO:0000146
GeneOntologyMolecularFunction	lipid kinase activity	PIP4K2B PIP4K2A	1.30e-03	41	26	2	GO:0001727
GeneOntologyMolecularFunction	nuclear retinoic acid receptor binding	PRAMEF18 CNOT1	2.32e-03	55	26	2	GO:0042974
GeneOntologyMolecularFunction	calmodulin binding	KCNN2 MYH2 MYH8	3.22e-03	230	26	3	GO:0005516
GeneOntologyBiologicalProcess	1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process	PIP4K2B PIP4K2A	4.58e-06	3	26	2	GO:1902635
GeneOntologyBiologicalProcess	1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate metabolic process	PIP4K2B PIP4K2A	9.15e-06	4	26	2	GO:1902633
GeneOntologyBiologicalProcess	autophagosome-lysosome fusion	PIP4K2B PIP4K2A	1.00e-04	12	26	2	GO:0061909
GeneOntologyBiologicalProcess	muscle filament sliding	MYH2 MYH8	1.59e-04	15	26	2	GO:0030049
GeneOntologyBiologicalProcess	actin-myosin filament sliding	MYH2 MYH8	2.31e-04	18	26	2	GO:0033275
GeneOntologyBiologicalProcess	positive regulation of organelle assembly	PIP4K2B CNOT1 PIP4K2A	2.42e-04	97	26	3	GO:1902117
GeneOntologyBiologicalProcess	positive regulation of autophagosome assembly	PIP4K2B PIP4K2A	2.86e-04	20	26	2	GO:2000786
GeneOntologyBiologicalProcess	regulation of organelle assembly	PIP4K2B CNOT1 EVI5L PIP4K2A	3.93e-04	280	26	4	GO:1902115
GeneOntologyBiologicalProcess	positive regulation of vacuole organization	PIP4K2B PIP4K2A	4.50e-04	25	26	2	GO:0044090
GeneOntologyBiologicalProcess	actin-mediated cell contraction	KCNN2 MYH2 MYH8	5.34e-04	127	26	3	GO:0070252
GeneOntologyCellularComponent	muscle myosin complex	MYH2 MYH8	1.63e-04	16	25	2	GO:0005859
GeneOntologyCellularComponent	myosin filament	MYH2 MYH8	4.05e-04	25	25	2	GO:0032982
GeneOntologyCellularComponent	myosin II complex	MYH2 MYH8	5.09e-04	28	25	2	GO:0016460
Domain	PInositol-4-P-5-kinase	PIP4K2B PIP4K2A	3.60e-05	7	25	2	IPR023610
Domain	PIPK	PIP4K2B PIP4K2A	4.79e-05	8	25	2	PS51455
Domain	PIPKc	PIP4K2B PIP4K2A	4.79e-05	8	25	2	SM00330
Domain	-	PIP4K2B PIP4K2A	4.79e-05	8	25	2	3.30.800.10
Domain	PInositol-4-P-5-kinase_N	PIP4K2B PIP4K2A	4.79e-05	8	25	2	IPR027484
Domain	PInositol-4-P-5-kinase_C	PIP4K2B PIP4K2A	4.79e-05	8	25	2	IPR027483
Domain	-	PIP4K2B PIP4K2A	4.79e-05	8	25	2	3.30.810.10
Domain	PInositol-4-P-5-kinase_core	PIP4K2B PIP4K2A	4.79e-05	8	25	2	IPR002498
Domain	PIP5K	PIP4K2B PIP4K2A	4.79e-05	8	25	2	PF01504
Domain	Myosin_N	MYH2 MYH8	1.79e-04	15	25	2	IPR004009
Domain	Myosin_N	MYH2 MYH8	1.79e-04	15	25	2	PF02736
Domain	Myosin_tail_1	MYH2 MYH8	2.60e-04	18	25	2	PF01576
Domain	Myosin_tail	MYH2 MYH8	2.60e-04	18	25	2	IPR002928
Domain	Myosin-like_IQ_dom	MYH2 MYH8	2.90e-04	19	25	2	IPR027401
Domain	-	MYH2 MYH8	2.90e-04	19	25	2	4.10.270.10
Domain	MYOSIN_MOTOR	MYH2 MYH8	1.17e-03	38	25	2	PS51456
Domain	Myosin_head	MYH2 MYH8	1.17e-03	38	25	2	PF00063
Domain	Myosin_head_motor_dom	MYH2 MYH8	1.17e-03	38	25	2	IPR001609
Domain	MYSc	MYH2 MYH8	1.17e-03	38	25	2	SM00242
Domain	IQ	MYH2 MYH8	4.04e-03	71	25	2	PF00612
Domain	IQ	MYH2 MYH8	5.22e-03	81	25	2	SM00015
Domain	IQ_motif_EF-hand-BS	MYH2 MYH8	6.41e-03	90	25	2	IPR000048
Domain	IQ	MYH2 MYH8	6.83e-03	93	25	2	PS50096
Pathway	REACTOME_PI5P_REGULATES_TP53_ACETYLATION	PIP4K2B PIP4K2A	6.84e-05	9	20	2	M27655
Pathway	REACTOME_PI5P_REGULATES_TP53_ACETYLATION	PIP4K2B PIP4K2A	6.84e-05	9	20	2	MM15357
Pubmed	Phosphatidylinositol-5-Phosphate 4-Kinases Regulate Cellular Lipid Metabolism By Facilitating Autophagy.	PIP4K2B PIP4K2A	5.37e-07	2	26	2	29727621
Pubmed	Depletion of a putatively druggable class of phosphatidylinositol kinases inhibits growth of p53-null tumors.	PIP4K2B PIP4K2A	1.61e-06	3	26	2	24209622
Pubmed	Functional analysis of the biochemical activity of mammalian phosphatidylinositol 5 phosphate 4-kinase enzymes.	PIP4K2B PIP4K2A	1.61e-06	3	26	2	30718367
Pubmed	The function of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) explored using a specific inhibitor that targets the PI5P-binding site.	PIP4K2B PIP4K2A	1.61e-06	3	26	2	25495341
Pubmed	Pharmacological inhibition of PI5P4Kα/β disrupts cell energy metabolism and selectively kills p53-null tumor cells.	PIP4K2B PIP4K2A	1.61e-06	3	26	2	34001596
Pubmed	The Lipid Kinase PI5P4Kβ Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis.	PIP4K2B PIP4K2A	1.61e-06	3	26	2	26774281
Pubmed	Evolutionarily conserved structural changes in phosphatidylinositol 5-phosphate 4-kinase (PI5P4K) isoforms are responsible for differences in enzyme activity and localization.	PIP4K2B PIP4K2A	1.61e-06	3	26	2	23758345
Pubmed	Evaluation of embryonic and perinatal myosin gene mutations and the etiology of congenital idiopathic clubfoot.	MYH2 MYH8	3.22e-06	4	26	2	20357587
Pubmed	A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate.	PIP4K2B PIP4K2A	3.22e-06	4	26	2	9367159
Pubmed	PIP4Ks Suppress Insulin Signaling through a Catalytic-Independent Mechanism.	PIP4K2B PIP4K2A	3.22e-06	4	26	2	31091439
Pubmed	PI5P4Ks drive metabolic homeostasis through peroxisome-mitochondria interplay.	PIP4K2B PIP4K2A	3.22e-06	4	26	2	33984270
Pubmed	Sequential accumulation of mRNAs encoding different myosin heavy chain isoforms during skeletal muscle development in vivo detected with a recombinant plasmid identified as coding for an adult fast myosin heavy chain from mouse skeletal muscle.	MYH2 MYH8	5.37e-06	5	26	2	6196357
Pubmed	Multigene family for sarcomeric myosin heavy chain in mouse and human DNA: localization on a single chromosome.	MYH2 TK1	5.37e-06	5	26	2	6879174
Pubmed	Myosin heavy chain isoforms of the murine masseter muscle during pre- and post-natal development.	MYH2 MYH8	5.37e-06	5	26	2	12919077
Pubmed	Distribution and localization of phosphatidylinositol 5-phosphate, 4-kinase alpha and beta in the brain.	PIP4K2B PIP4K2A	5.37e-06	5	26	2	32449185
Pubmed	Developmental pattern of mouse skeletal myosin heavy chain gene transcripts in vivo and in vitro.	MYH2 MYH8	5.37e-06	5	26	2	3829126
Pubmed	Organization of human and mouse skeletal myosin heavy chain gene clusters is highly conserved.	MYH2 MYH8	8.05e-06	6	26	2	10077619
Pubmed	Distinct myogenic programs of embryonic and fetal mouse muscle cells: expression of the perinatal myosin heavy chain isoform in vitro.	MYH2 MYH8	8.05e-06	6	26	2	1728586
Pubmed	Spatial and temporal changes in myosin heavy chain gene expression in skeletal muscle development.	MYH2 MYH8	8.05e-06	6	26	2	10588881
Pubmed	Branches of the B cell antigen receptor pathway are directed by protein conduits Bam32 and Carma1.	PIP4K2B PIP4K2A	8.05e-06	6	26	2	14614850
Pubmed	Localization of mRNAs for phosphatidylinositol phosphate kinases in the mouse brain during development.	PIP4K2B PIP4K2A	1.13e-05	7	26	2	15018809
Pubmed	Diversity in transcriptional start site selection and alternative splicing affects the 5'-UTR of mouse striated muscle myosin transcripts.	MYH2 MYH8	1.13e-05	7	26	2	16819597
Pubmed	A fast Myosin super enhancer dictates muscle fiber phenotype through competitive interactions with Myosin genes.	MYH2 MYH8	1.13e-05	7	26	2	35210422
Pubmed	Phosphatidylinositol-4-phosphate 5-kinases and phosphatidylinositol 4,5-bisphosphate synthesis in the brain.	PIP4K2B PIP4K2A	1.50e-05	8	26	2	20622009
Pubmed	Btk-dependent regulation of phosphoinositide synthesis.	PIP4K2B PIP4K2A	1.50e-05	8	26	2	15046600
Pubmed	Transdifferentiation of esophageal smooth to skeletal muscle is myogenic bHLH factor-dependent.	MYH2 MYH8	1.93e-05	9	26	2	10725239
Pubmed	Acceleration of somitic myogenesis in embryos of myogenin promoter-MRF4 transgenic mice.	MYH2 MYH8	2.41e-05	10	26	2	8950513
Pubmed	PI(5)P regulates autophagosome biogenesis.	PIP4K2B PIP4K2A	2.41e-05	10	26	2	25578879
Pubmed	Modulation of contractile protein gene expression in fetal murine crural muscles: emergence of muscle diversity.	MYH2 MYH8	2.94e-05	11	26	2	8136524
Pubmed	Dysregulation of nuclear receptor COUP-TFII impairs skeletal muscle development.	MYH2 MYH8	3.53e-05	12	26	2	28600496
Pubmed	The inhibition of differentiation caused by TGFbeta in fetal myoblasts is dependent upon selective expression of PKCtheta: a possible molecular basis for myoblast diversification during limb histogenesis.	MYH2 MYH8	4.17e-05	13	26	2	8948582
Pubmed	Contractile protein gene expression in primary myotubes of embryonic mouse hindlimb muscles.	MYH2 MYH8	4.17e-05	13	26	2	8404542
Pubmed	Defective excitation-contraction coupling is partially responsible for impaired contractility in hindlimb muscles of Stac3 knockout mice.	MYH2 MYH8	4.86e-05	14	26	2	27184118
Pubmed	Slow and fast fiber isoform gene expression is systematically altered in skeletal muscle of the Sox6 mutant, p100H.	MYH2 MYH8	7.26e-05	17	26	2	16124007
Pubmed	Tbx15 controls skeletal muscle fibre-type determination and muscle metabolism.	MYH2 ACACA	1.01e-04	20	26	2	26299309
Pubmed	NotI flanking sequences: a tool for gene discovery and verification of the human genome.	LAMA3 PIP4K2B	1.12e-04	21	26	2	12136098
Pubmed	A new role for the calcineurin/NFAT pathway in neonatal myosin heavy chain expression via the NFATc2/MyoD complex during mouse myogenesis.	MYH2 MYH8	1.23e-04	22	26	2	24301466
Pubmed	Synemin acts as a regulator of signalling molecules during skeletal muscle hypertrophy.	MYH2 MYH8	2.01e-04	28	26	2	25179606
Pubmed	HOXA5 Participates in Brown Adipose Tissue and Epaxial Skeletal Muscle Patterning and in Brown Adipocyte Differentiation.	MYH2 MYH8	2.63e-04	32	26	2	33732701
Pubmed	Myosin heavy chain-embryonic regulates skeletal muscle differentiation during mammalian development.	MYH2 MYH8	2.80e-04	33	26	2	32094117
Pubmed	Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS.	PIP4K2B CUL7 ACACA PIP4K2A	2.83e-04	432	26	4	23455922
Pubmed	Temporal regulation of the Mediator complex during muscle proliferation, differentiation, regeneration, aging, and disease.	MYH2 MYH8	3.91e-04	39	26	2	38690566
Pubmed	Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells.	APEH ACACA TK1 CNOT1 CLPTM1 PSMB4	4.27e-04	1367	26	6	32687490
Pubmed	Identification and characterization of proteins interacting with SIRT1 and SIRT3: implications in the anti-aging and metabolic effects of sirtuins.	LAMA3 ACACA	4.33e-04	41	26	2	19343720
Pubmed	Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.	PIP4K2B MYH2 MYH8 CUL7 PIP4K2A	5.05e-04	910	26	5	36736316
Pubmed	HOXA5 plays tissue-specific roles in the developing respiratory system.	MYH2 MYH8	5.45e-04	46	26	2	28827394
Pubmed	A conserved acetylation switch enables pharmacological control of tubby-like protein stability.	PIP4K2B CUL7 PIP4K2A	6.06e-04	223	26	3	33187986
Pubmed	PIKES Analysis Reveals Response to Degraders and Key Regulatory Mechanisms of the CRL4 Network.	PIP4K2B PIP4K2A	6.18e-04	49	26	2	31973889
Pubmed	Global mapping of herpesvirus-host protein complexes reveals a transcription strategy for late genes.	APEH PIP4K2B CNOT1 PIP4K2A	6.24e-04	533	26	4	25544563
Pubmed	Host E3 ligase HUWE1 attenuates the proapoptotic activity of the MERS-CoV accessory protein ORF3 by promoting its ubiquitin-dependent degradation.	APEH ACACA CNOT1 PSMB4	6.28e-04	534	26	4	35032548
Pubmed	Six1 homeoprotein drives myofiber type IIA specialization in soleus muscle.	MYH2 MYH8	6.44e-04	50	26	2	27597886
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	KCNN2 LAMA3 CERS6 ACACA CNOT1 EVI5L	6.71e-04	1489	26	6	28611215
Interaction	GPBP1L1 interactions	PIP4K2B IL3RA CNOT1 PIP4K2A	3.65e-06	86	25	4	int:GPBP1L1
GeneFamily	Myosin heavy chains	MYH2 MYH8	8.67e-05	15	17	2	1098
Drug	dimolybdenum	APEH ACACA	3.47e-06	3	25	2	CID000142899
Disease	autosomal dominant hyaline body myopathy (implicated_via_orthology)	MYH2 MYH8	2.84e-05	10	24	2	DOID:0111269 (implicated_via_orthology)
Disease	dilated cardiomyopathy 1S (implicated_via_orthology)	MYH2 MYH8	2.84e-05	10	24	2	DOID:0110454 (implicated_via_orthology)
Disease	distal arthrogryposis type 2B3 (implicated_via_orthology)	MYH2 MYH8	2.84e-05	10	24	2	DOID:0111602 (implicated_via_orthology)
Disease	inclusion body myositis (implicated_via_orthology)	MYH2 MYH8	2.84e-05	10	24	2	DOID:3429 (implicated_via_orthology)
Disease	congenital myopathy 6 (implicated_via_orthology)	MYH2 MYH8	2.84e-05	10	24	2	DOID:0080719 (implicated_via_orthology)
Disease	distal arthrogryposis type 2A (implicated_via_orthology)	MYH2 MYH8	2.84e-05	10	24	2	DOID:0111605 (implicated_via_orthology)
Disease	familial hypertrophic cardiomyopathy (implicated_via_orthology)	MYH2 MYH8	2.84e-05	10	24	2	DOID:0080326 (implicated_via_orthology)
Disease	distal arthrogryposis type 1 (implicated_via_orthology)	MYH2 MYH8	2.84e-05	10	24	2	DOID:0111596 (implicated_via_orthology)
Disease	distal myopathy (implicated_via_orthology)	MYH2 MYH8	4.16e-05	12	24	2	DOID:11720 (implicated_via_orthology)
Disease	myotonia congenita (implicated_via_orthology)	MYH2 MYH8	4.16e-05	12	24	2	DOID:2106 (implicated_via_orthology)
Disease	restrictive cardiomyopathy (implicated_via_orthology)	MYH2 MYH8	4.92e-05	13	24	2	DOID:397 (implicated_via_orthology)
Disease	distal arthrogryposis (implicated_via_orthology)	MYH2 MYH8	6.61e-05	15	24	2	DOID:0050646 (implicated_via_orthology)
Disease	myopathy (implicated_via_orthology)	MYH2 MYH8	6.99e-04	48	24	2	DOID:423 (implicated_via_orthology)
Disease	cardiomyopathy (implicated_via_orthology)	MYH2 MYH8	1.52e-03	71	24	2	DOID:0050700 (implicated_via_orthology)
Disease	dilated cardiomyopathy (implicated_via_orthology)	MYH2 MYH8	1.93e-03	80	24	2	DOID:12930 (implicated_via_orthology)
Disease	RS-10-hydroxywarfarin to RS-warfarin ratio measurement	CERS6 TRPC3	3.60e-03	110	24	2	EFO_0803335
Disease	obsolete_red blood cell distribution width	APEH CERS6 TK1 CLPTM1 PSMB4	4.05e-03	1347	24	5	EFO_0005192
Disease	gestational age	KCNN2 PNMA5	5.60e-03	138	24	2	EFO_0005112
Disease	Liver carcinoma	KCNN2 ACACA TK1	7.80e-03	507	24	3	C2239176
Disease	electrocardiography	KCNN2 EXOG CNOT1	8.81e-03	530	24	3	EFO_0004327

Protein segments in the cluster

Peptide	Gene	Start	Entry
FCVFVRLMQEYRLRE	EVI5L	216	Q96CN4
SYEMFRNERAIRFVV	ACACA	141	Q13085
RDLVERCMRVLYYRD	PSMB4	211	P28070
RRMLECLFYVFDPEV	LRRC9	466	Q6ZRR7
VMDRVKFQRIYQFAR	LAMA3	2486	Q16787
RIAMTYERIFFICLE	KCNN2	206	Q9H2S1
REALFCIQYNVRAFM	MYH8	811	P13535
EYQRMVERREAIFCI	MYH2	806	Q9UKX2
VFREQLCRHTRLFYM	CUL7	976	Q14999
LENLQMLYVRRVCFF	PRAMEF18	266	Q5VWM3
NRIEMYCRELTERFE	EXOG	176	Q9Y2C4
LMRRVRRFQIAQYKC	TK1	36	P04183
VFVICRRYLVMQRLF	IL3RA	321	P26951
FCIFMVRLIFERFVA	CERS6	46	Q6ZMG9
KEYCPMVFRNLRERF	PIP4K2A	91	P48426
ARFQLFLRRYEEFMV	FADS6	331	Q8N9I5
RLHQMCRVRDVLDFY	MRPL50	116	Q8N5N7
LRMRVFGLCFVRFAI	SLC22A24	346	Q8N4F4
KEYCPMVFRNLRERF	PIP4K2B	96	P78356
ERMENIRFCRQYLVF	APEH	56	P13798
MYRIGCLRDDVVFFI	CLPTM1	566	O96005
EVFNCMLRNLFEEYR	CNOT1	886	A5YKK6
LCAYRVLGRMFRRED	PNMA5	46	Q96PV4
FQKVMLRRYERCCLE	ZNF695	106	Q8IW36
RLEMEFQRCQYVVGR	VAX2	116	Q9UIW0
YFIMRIVNFPKCRRR	TRPC3	706	Q13507