Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	gated channel activity	KCND3 PIEZO1 TMC8 TMEM63C HTR3B RYR1 CHRNB3 RYR2	1.39e-05	334	66	8	GO:0022836
GeneOntologyMolecularFunction	monoatomic cation channel activity	KCND3 PIEZO1 SCN8A TMEM63C HTR3B RYR1 CHRNB3 RYR2	1.69e-05	343	66	8	GO:0005261
GeneOntologyMolecularFunction	monoatomic ion channel activity	KCND3 PIEZO1 SCN8A TMC8 TMEM63C HTR3B RYR1 CHRNB3 RYR2	1.92e-05	459	66	9	GO:0005216
GeneOntologyMolecularFunction	1-acylglycerol-3-phosphate O-acyltransferase activity	AGPAT5 MBOAT7 GPAT4	4.40e-05	21	66	3	GO:0003841
GeneOntologyMolecularFunction	channel activity	KCND3 PIEZO1 SCN8A TMC8 TMEM63C HTR3B RYR1 CHRNB3 RYR2	5.47e-05	525	66	9	GO:0015267
GeneOntologyMolecularFunction	passive transmembrane transporter activity	KCND3 PIEZO1 SCN8A TMC8 TMEM63C HTR3B RYR1 CHRNB3 RYR2	5.56e-05	526	66	9	GO:0022803
GeneOntologyMolecularFunction	ryanodine-sensitive calcium-release channel activity	RYR1 RYR2	6.43e-05	4	66	2	GO:0005219
GeneOntologyMolecularFunction	transporter activity	ABCG4 KCND3 PIEZO1 SCN8A TMC8 TMEM63C SLC15A5 ATP9B HTR3B STRA6 SLC36A2 RYR1 CHRNB3 RYR2	6.61e-05	1289	66	14	GO:0005215
GeneOntologyMolecularFunction	lysophosphatidic acid acyltransferase activity	AGPAT5 MBOAT7 GPAT4	6.64e-05	24	66	3	GO:0042171
GeneOntologyMolecularFunction	lysophospholipid acyltransferase activity	AGPAT5 MBOAT7 GPAT4	6.64e-05	24	66	3	GO:0071617
GeneOntologyMolecularFunction	ligand-gated monoatomic cation channel activity	TMEM63C HTR3B RYR1 CHRNB3 RYR2	1.00e-04	140	66	5	GO:0099094
GeneOntologyMolecularFunction	transmembrane transporter activity	ABCG4 KCND3 PIEZO1 SCN8A TMC8 TMEM63C SLC15A5 HTR3B STRA6 SLC36A2 RYR1 CHRNB3 RYR2	1.09e-04	1180	66	13	GO:0022857
GeneOntologyMolecularFunction	acylglycerol O-acyltransferase activity	AGPAT5 MBOAT7 GPAT4	1.60e-04	32	66	3	GO:0016411
GeneOntologyMolecularFunction	calcium-induced calcium release activity	RYR1 RYR2	1.60e-04	6	66	2	GO:0048763
GeneOntologyMolecularFunction	monoatomic ion transmembrane transporter activity	KCND3 PIEZO1 SCN8A TMC8 TMEM63C HTR3B SLC36A2 RYR1 CHRNB3 RYR2	2.59e-04	793	66	10	GO:0015075
GeneOntologyMolecularFunction	monoatomic cation transmembrane transporter activity	KCND3 PIEZO1 SCN8A TMEM63C HTR3B SLC36A2 RYR1 CHRNB3 RYR2	3.21e-04	664	66	9	GO:0008324
GeneOntologyMolecularFunction	glycosyltransferase activity	TMTC1 PIGA UGT2B15 UGT2B17 B4GALT5 TIPARP	3.76e-04	288	66	6	GO:0016757
GeneOntologyMolecularFunction	ligand-gated monoatomic ion channel activity	TMEM63C HTR3B RYR1 CHRNB3 RYR2	4.44e-04	193	66	5	GO:0015276
GeneOntologyMolecularFunction	ligand-gated channel activity	TMEM63C HTR3B RYR1 CHRNB3 RYR2	4.87e-04	197	66	5	GO:0022834
GeneOntologyMolecularFunction	retinoid binding	UGT2B15 UGT2B17 STRA6	5.36e-04	48	66	3	GO:0005501
GeneOntologyMolecularFunction	isoprenoid binding	UGT2B15 UGT2B17 STRA6	5.70e-04	49	66	3	GO:0019840
GeneOntologyMolecularFunction	hexosyltransferase activity	TMTC1 PIGA UGT2B15 UGT2B17 B4GALT5	6.65e-04	211	66	5	GO:0016758
GeneOntologyMolecularFunction	O-acyltransferase activity	AGPAT5 MBOAT7 GPAT4	9.82e-04	59	66	3	GO:0008374
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	VIPR1 CXCR3 OR2AK2 KISS1R GPR158 IL17RE TMEM63C OR1K1 FCRLA HTR3B OR4K15 CHRNB3	1.44e-03	1353	66	12	GO:0004888
GeneOntologyMolecularFunction	mechanosensitive monoatomic ion channel activity	PIEZO1 TMC8	1.59e-03	18	66	2	GO:0008381
GeneOntologyMolecularFunction	intracellularly gated calcium channel activity	RYR1 RYR2	1.59e-03	18	66	2	GO:0015278
GeneOntologyMolecularFunction	UDP-glycosyltransferase activity	PIGA UGT2B15 UGT2B17 B4GALT5	1.65e-03	153	66	4	GO:0008194
GeneOntologyMolecularFunction	retinoic acid binding	UGT2B15 UGT2B17	3.85e-03	28	66	2	GO:0001972
GeneOntologyMolecularFunction	neurotransmitter receptor activity	GPR158 HTR3B CHRNB3	4.44e-03	100	66	3	GO:0030594
GeneOntologyBiologicalProcess	estrogen metabolic process	UGT2B15 UGT2B17 HSD17B1 TIPARP	2.31e-05	52	66	4	GO:0008210
GeneOntologyCellularComponent	endoplasmic reticulum membrane	TMX2 ESYT2 PIGA AGPAT5 RETREG2 SBF1 MBOAT7 WFS1 PIEZO1 TMC8 UGT2B15 UGT2B17 TMEM39A GPAT4 SLC36A2 RYR1 RYR2 PROS1	1.03e-07	1293	68	18	GO:0005789
GeneOntologyCellularComponent	endoplasmic reticulum subcompartment	TMX2 ESYT2 PIGA AGPAT5 RETREG2 SBF1 MBOAT7 WFS1 PIEZO1 TMC8 UGT2B15 UGT2B17 TMEM39A GPAT4 SLC36A2 RYR1 RYR2 PROS1	1.10e-07	1299	68	18	GO:0098827
GeneOntologyCellularComponent	nuclear outer membrane-endoplasmic reticulum membrane network	TMX2 ESYT2 PIGA AGPAT5 RETREG2 SBF1 MBOAT7 WFS1 PIEZO1 TMC8 UGT2B15 UGT2B17 TMEM39A GPAT4 SLC36A2 RYR1 RYR2 PROS1	1.52e-07	1327	68	18	GO:0042175
GeneOntologyCellularComponent	junctional sarcoplasmic reticulum membrane	RYR1 RYR2	4.61e-04	10	68	2	GO:0014701
GeneOntologyCellularComponent	organelle membrane contact site	TMX2 ESYT2 MBOAT7	8.50e-04	57	68	3	GO:0044232
GeneOntologyCellularComponent	cation channel complex	KCND3 SCN8A HTR3B RYR1 RYR2	1.01e-03	235	68	5	GO:0034703
GeneOntologyCellularComponent	monoatomic ion channel complex	KCND3 SCN8A HTR3B RYR1 CHRNB3 RYR2	1.43e-03	378	68	6	GO:0034702
Domain	Ryanrecept_TM4-6	RYR1 RYR2	3.68e-05	3	66	2	IPR009460
Domain	RyR	RYR1 RYR2	3.68e-05	3	66	2	PF02026
Domain	Ryanodine_rcpt	RYR1 RYR2	3.68e-05	3	66	2	IPR003032
Domain	RR_TM4-6	RYR1 RYR2	3.68e-05	3	66	2	PF06459
Domain	Ryan_recept	RYR1 RYR2	3.68e-05	3	66	2	IPR013333
Domain	RIH_assoc	RYR1 RYR2	1.83e-04	6	66	2	PF08454
Domain	RIH_assoc-dom	RYR1 RYR2	1.83e-04	6	66	2	IPR013662
Domain	RIH_dom	RYR1 RYR2	1.83e-04	6	66	2	IPR000699
Domain	Ins145_P3_rcpt	RYR1 RYR2	1.83e-04	6	66	2	IPR014821
Domain	Ryanodine_recept-rel	RYR1 RYR2	1.83e-04	6	66	2	IPR015925
Domain	-	RYR1 RYR2	1.83e-04	6	66	2	1.25.10.30
Domain	RYDR_ITPR	RYR1 RYR2	1.83e-04	6	66	2	PF01365
Domain	Ins145_P3_rec	RYR1 RYR2	1.83e-04	6	66	2	PF08709
Domain	MIR	RYR1 RYR2	5.43e-04	10	66	2	PS50919
Domain	MIR	RYR1 RYR2	5.43e-04	10	66	2	PF02815
Domain	MIR	RYR1 RYR2	5.43e-04	10	66	2	SM00472
Domain	MIR_motif	RYR1 RYR2	5.43e-04	10	66	2	IPR016093
Domain	Ion_trans_dom	KCND3 SCN8A RYR1 RYR2	7.09e-04	114	66	4	IPR005821
Domain	Ion_trans	KCND3 SCN8A RYR1 RYR2	7.09e-04	114	66	4	PF00520
Domain	Acyltransferase	AGPAT5 GPAT4	1.43e-03	16	66	2	PF01553
Domain	PlsC	AGPAT5 GPAT4	1.62e-03	17	66	2	SM00563
Domain	Plipid/glycerol_acylTrfase	AGPAT5 GPAT4	1.62e-03	17	66	2	IPR002123
Domain	IQ	SCN8A CAMTA2 UBE3C	2.03e-03	71	66	3	PF00612
Domain	UDPGT	UGT2B15 UGT2B17	2.47e-03	21	66	2	PF00201
Domain	UDPGT	UGT2B15 UGT2B17	2.47e-03	21	66	2	PS00375
Domain	UDP_glucos_trans	UGT2B15 UGT2B17	2.47e-03	21	66	2	IPR002213
Domain	IQ	SCN8A CAMTA2 UBE3C	2.95e-03	81	66	3	SM00015
Domain	-	HTR3B CHRNB3	2.97e-03	23	66	2	1.20.120.370
Domain	Acetylcholine_rcpt_TM	HTR3B CHRNB3	2.97e-03	23	66	2	IPR027361
Domain	IQ_motif_EF-hand-BS	SCN8A CAMTA2 UBE3C	3.98e-03	90	66	3	IPR000048
Domain	HECT	HECW2 UBE3C	4.08e-03	27	66	2	PF00632
Domain	HECTc	HECW2 UBE3C	4.08e-03	27	66	2	SM00119
Domain	HECT_dom	HECW2 UBE3C	4.08e-03	27	66	2	IPR000569
Domain	HECT	HECW2 UBE3C	4.08e-03	27	66	2	PS50237
Domain	IQ	SCN8A CAMTA2 UBE3C	4.36e-03	93	66	3	PS50096
Domain	EF-hand_8	RYR1 RYR2	6.41e-03	34	66	2	PF13833
Pubmed	Expression of UDP Glucuronosyltransferases 2B15 and 2B17 is associated with methylation status in prostate cancer cells.	UGT2B15 UGT2B17	3.77e-06	2	68	2	32660355
Pubmed	Skeletal and cardiac ryanodine receptors exhibit different responses to Ca2+ overload and luminal ca2+.	RYR1 RYR2	3.77e-06	2	68	2	17259277
Pubmed	Ryanodine receptor oligomeric interaction: identification of a putative binding region.	RYR1 RYR2	3.77e-06	2	68	2	14722100
Pubmed	The UDP glucuronosyltransferase gene superfamily: suggested nomenclature based on evolutionary divergence.	UGT2B15 UGT2B17	3.77e-06	2	68	2	1909870
Pubmed	Structural and functional interactions within ryanodine receptor.	RYR1 RYR2	3.77e-06	2	68	2	26009179
Pubmed	Androgen glucuronidation: an unexpected target for androgen deprivation therapy, with prognosis and diagnostic implications.	UGT2B15 UGT2B17	3.77e-06	2	68	2	24121496
Pubmed	Structure and Function of the Human Ryanodine Receptors and Their Association with Myopathies-Present State, Challenges, and Perspectives.	RYR1 RYR2	3.77e-06	2	68	2	32899693
Pubmed	Mouse UDP glucuronosyltransferase. cDNA and complete amino acid sequence and regulation.	UGT2B15 UGT2B17	3.77e-06	2	68	2	3117546
Pubmed	Novel associations of UDP-glucuronosyltransferase 2B gene variants with prostate cancer risk in a multiethnic study.	UGT2B15 UGT2B17	3.77e-06	2	68	2	24267955
Pubmed	Recent advances in understanding the ryanodine receptor calcium release channels and their role in calcium signalling.	RYR1 RYR2	3.77e-06	2	68	2	30542613
Pubmed	Differential expression of the androgen-conjugating UGT2B15 and UGT2B17 enzymes in prostate tumor cells during cancer progression.	UGT2B15 UGT2B17	3.77e-06	2	68	2	22170718
Pubmed	Localization and phenotype-specific expression of ryanodine calcium release channels in C57BL6 and DBA/2J mouse strains.	GPNMB RYR1	3.77e-06	2	68	2	21933672
Pubmed	Ryanodine receptors are expressed and functionally active in mouse spermatogenic cells and their inhibition interferes with spermatogonial differentiation.	RYR1 RYR2	3.77e-06	2	68	2	15280431
Pubmed	Expression of the ryanodine receptor isoforms in immune cells.	RYR1 RYR2	3.77e-06	2	68	2	11673493
Pubmed	B-lymphocytes from malignant hyperthermia-susceptible patients have an increased sensitivity to skeletal muscle ryanodine receptor activators.	RYR1 RYR2	3.77e-06	2	68	2	11673462
Pubmed	Localization of UDP glucuronosyltransferase gene(s) on mouse chromosome 5.	UGT2B15 UGT2B17	3.77e-06	2	68	2	3105095
Pubmed	UDP-glucuronosyltransferase 2B15 (UGT2B15) and UGT2B17 enzymes are major determinants of the androgen response in prostate cancer LNCaP cells.	UGT2B15 UGT2B17	3.77e-06	2	68	2	17848572
Pubmed	Crystal structures of wild type and disease mutant forms of the ryanodine receptor SPRY2 domain.	RYR1 RYR2	3.77e-06	2	68	2	25370123
Pubmed	Androgen and Estrogen Receptors in Breast Cancer Coregulate Human UDP-Glucuronosyltransferases 2B15 and 2B17.	UGT2B15 UGT2B17	3.77e-06	2	68	2	27496708
Pubmed	Ryanodine receptors in human pancreatic beta cells: localization and effects on insulin secretion.	RYR1 RYR2	3.77e-06	2	68	2	15033925
Pubmed	Comprehensive Characterization of Mouse UDP-Glucuronosyltransferase (Ugt) Belonging to the Ugt2b Subfamily: Identification of Ugt2b36 as the Predominant Isoform Involved in Morphine Glucuronidation.	UGT2B15 UGT2B17	3.77e-06	2	68	2	28228532
Pubmed	Thermodynamics of calmodulin binding to cardiac and skeletal muscle ryanodine receptor ion channels.	RYR1 RYR2	3.77e-06	2	68	2	18618700
Pubmed	Cellular specific expression of the androgen-conjugating enzymes UGT2B15 and UGT2B17 in the human prostate epithelium.	UGT2B15 UGT2B17	3.77e-06	2	68	2	15666817
Pubmed	The uridine diphosphate glucuronosyltransferase 2B15 D85Y and 2B17 deletion polymorphisms predict the glucuronidation pattern of androgens and fat mass in men.	UGT2B15 UGT2B17	3.77e-06	2	68	2	17698910
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	SBF1 IL17RE KLHL21 PIEZO1 SCN8A TSC2 UBE3C ARHGAP35 SNAPC4 GPAT4 RYR1	9.26e-06	1105	68	11	35748872
Pubmed	Type 1 and type 3 ryanodine receptors are selectively involved in muscarinic antinociception in mice: an antisense study.	RYR1 RYR2	1.13e-05	3	68	2	18403125
Pubmed	Copy-number variations (CNVs) of the human sex steroid metabolizing genes UGT2B17 and UGT2B28 and their associations with a UGT2B15 functional polymorphism.	UGT2B15 UGT2B17	1.13e-05	3	68	2	19572376
Pubmed	Circ_0057583 facilitates brain microvascular endothelial cell injury through modulating miR-204-5p/NR4A1 axis.	HECW2 NR4A1	1.13e-05	3	68	2	34767155
Pubmed	Estrogen maintains myometrial tumors in a lymphangioleiomyomatosis model.	TSC2 GPNMB	1.13e-05	3	68	2	26880751
Pubmed	Heterogeneous gene expression and functional activity of ryanodine receptors in resistance and conduit pulmonary as well as mesenteric artery smooth muscle cells.	RYR1 RYR2	1.13e-05	3	68	2	18434746
Pubmed	Regulation of Human UGT2B15 and UGT2B17 by miR-376c in Prostate Cancer Cell Lines.	UGT2B15 UGT2B17	1.13e-05	3	68	2	26163549
Pubmed	Forkhead box protein A1 regulates UDP-glucuronosyltransferase 2B15 gene transcription in LNCaP prostate cancer cells.	UGT2B15 UGT2B17	1.13e-05	3	68	2	20736324
Pubmed	SPRY domains in ryanodine receptors (Ca(2+)-release channels).	RYR1 RYR2	1.13e-05	3	68	2	9204703
Pubmed	The ryanodine receptor/calcium channel genes are widely and differentially expressed in murine brain and peripheral tissues.	RYR1 RYR2	1.13e-05	3	68	2	7876312
Pubmed	Ryanodine receptors are expressed in epidermal keratinocytes and associated with keratinocyte differentiation and epidermal permeability barrier homeostasis.	RYR1 RYR2	1.13e-05	3	68	2	21881589
Pubmed	Dendritic differentiation of cerebellar Purkinje cells is promoted by ryanodine receptors expressed by Purkinje and granule cells.	RYR1 RYR2	1.13e-05	3	68	2	24123915
Pubmed	Epigenetic regulation of steroid inactivating UDP-glucuronosyltransferases by microRNAs in prostate cancer.	UGT2B15 UGT2B17	1.13e-05	3	68	2	26385605
Pubmed	Genetic variations in UGT2B28, UGT2B17, UGT2B15 genes and the risk of prostate cancer: A case-control study.	UGT2B15 UGT2B17	1.13e-05	3	68	2	28882566
Pubmed	Isoform-dependent formation of heteromeric Ca2+ release channels (ryanodine receptors).	RYR1 RYR2	1.13e-05	3	68	2	12213830
Pubmed	Dopamine D1 receptor signaling system regulates ryanodine receptor expression in ethanol physical dependence.	RYR1 RYR2	1.13e-05	3	68	2	23278119
Pubmed	Expression of the ryanodine receptor type 3 calcium release channel during development and differentiation of mammalian skeletal muscle cells.	RYR1 RYR2	1.13e-05	3	68	2	9242641
Pubmed	Bidirectional coupling between ryanodine receptors and Ca2+ release-activated Ca2+ (CRAC) channel machinery sustains store-operated Ca2+ entry in human T lymphocytes.	RYR1 RYR2	1.13e-05	3	68	2	22948152
Pubmed	Direct association of the reticulon protein RTN1A with the ryanodine receptor 2 in neurons.	RYR1 RYR2	1.13e-05	3	68	2	23454728
Pubmed	Developmental changes in expression of the three ryanodine receptor mRNAs in the mouse brain.	RYR1 RYR2	1.13e-05	3	68	2	10788707
Pubmed	Activators of the farnesoid X receptor negatively regulate androgen glucuronidation in human prostate cancer LNCAP cells.	UGT2B15 UGT2B17	1.13e-05	3	68	2	17988216
Pubmed	Calcineurin upregulates local Ca(2+) signaling through ryanodine receptor-1 in airway smooth muscle cells.	RYR1 RYR2	1.13e-05	3	68	2	25239916
Pubmed	Ca(2+)-induced Ca2+ release in myocytes from dyspedic mice lacking the type-1 ryanodine receptor.	RYR1 RYR2	1.13e-05	3	68	2	7621815
Pubmed	A gene-specific cerebral types 1, 2, and 3 RyR protein knockdown induces an antidepressant-like effect in mice.	RYR1 RYR2	1.13e-05	3	68	2	18643873
Pubmed	Identification of mutations in the cardiac ryanodine receptor gene in families affected with arrhythmogenic right ventricular cardiomyopathy type 2 (ARVD2).	RYR1 RYR2	1.13e-05	3	68	2	11159936
Pubmed	Tissue distribution and relative gene expression of UDP-glucuronosyltransferases (2B7, 2B15, 2B17) in the human fetus.	UGT2B15 UGT2B17	1.13e-05	3	68	2	23223495
Pubmed	Intracellular calcium release channel expression during embryogenesis.	RYR1 RYR2	1.13e-05	3	68	2	9986730
Pubmed	Androgen receptor mediates the expression of UDP-glucuronosyltransferase 2 B15 and B17 genes.	UGT2B15 UGT2B17	1.13e-05	3	68	2	18302198
Pubmed	The nuclear receptor Shp regulates morphine withdrawal syndrome via modulation of Ugt2b expression in mice.	UGT2B15 UGT2B17	1.13e-05	3	68	2	30689982
Pubmed	Molecular identification of the ryanodine receptor pore-forming segment.	RYR1 RYR2	1.13e-05	3	68	2	10473538
Pubmed	Chromosomal localization of murine ryanodine receptor genes RYR1, RYR2, and RYR3 by in situ hybridization.	RYR1 RYR2	1.13e-05	3	68	2	7959768
Pubmed	The organization of proteins in the human red blood cell membrane. A review.	RYR1 RYR2	1.13e-05	3	68	2	4600883
Pubmed	Regulation of mouse egg activation: presence of ryanodine receptors and effects of microinjected ryanodine and cyclic ADP ribose on uninseminated and inseminated eggs.	RYR1 RYR2	1.13e-05	3	68	2	7635066
Pubmed	A glutathione deficit alters dopamine modulation of L-type calcium channels via D2 and ryanodine receptors in neurons.	RYR1 RYR2	2.25e-05	4	68	2	18206662
Pubmed	Increase of ryanodine receptors by dopamine D1 receptors is negatively regulated by γ-aminobutyric acid type B receptors in primary cultures of mouse cerebral cortical neurons.	RYR1 RYR2	2.25e-05	4	68	2	22504960
Pubmed	Calmodulin modulates the termination threshold for cardiac ryanodine receptor-mediated Ca2+ release.	RYR1 RYR2	2.25e-05	4	68	2	23992453
Pubmed	Ryanodine receptor calcium release channels: lessons from structure-function studies.	RYR1 RYR2	2.25e-05	4	68	2	23413940
Pubmed	Requirement for the ryanodine receptor type 3 for efficient contraction in neonatal skeletal muscles.	RYR1 RYR2	2.25e-05	4	68	2	9384575
Pubmed	Partial cloning and differential expression of ryanodine receptor/calcium-release channel genes in human tissues including the hippocampus and cerebellum.	RYR1 RYR2	2.25e-05	4	68	2	9607712
Pubmed	S100A1 Protein Does Not Compete with Calmodulin for Ryanodine Receptor Binding but Structurally Alters the Ryanodine Receptor·Calmodulin Complex.	RYR1 RYR2	2.25e-05	4	68	2	27226555
Pubmed	Calcitrol (1alpha,25-dihydroxyvitamin D3) inhibits androgen glucuronidation in prostate cancer cells.	UGT2B15 UGT2B17	2.25e-05	4	68	2	18281521
Pubmed	Impacts of the Glucuronidase Genotypes UGT1A4, UGT2B7, UGT2B15 and UGT2B17 on Tamoxifen Metabolism in Breast Cancer Patients.	UGT2B15 UGT2B17	2.25e-05	4	68	2	26176234
Pubmed	Hypoxia differently modulates gene expression of inositol 1,4,5-trisphosphate receptors in mouse kidney and HEK 293 cell line.	RYR1 RYR2	2.25e-05	4	68	2	19120137
Pubmed	FKBP binding characteristics of cardiac microsomes from diverse vertebrates.	RYR1 RYR2	2.25e-05	4	68	2	11237759
Pubmed	Conserved and divergent functions of Nfix in skeletal muscle development during vertebrate evolution.	RYR1 RYR2	2.25e-05	4	68	2	23482488
Pubmed	Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.	VIPR1 TSC2 HTR3B ARHGAP35 SDC2 CHRNB3	2.74e-05	300	68	6	19086053
Pubmed	Role of leaky neuronal ryanodine receptors in stress-induced cognitive dysfunction.	RYR1 RYR2	3.75e-05	5	68	2	22939628
Pubmed	Intracellular calcium-release channels: regulators of cell life and death.	RYR1 RYR2	3.75e-05	5	68	2	9124414
Pubmed	Presenilins regulate calcium homeostasis and presynaptic function via ryanodine receptors in hippocampal neurons.	RYR1 RYR2	3.75e-05	5	68	2	23918386
Pubmed	Protein kinase C-epsilon regulates local calcium signaling in airway smooth muscle cells.	RYR1 RYR2	3.75e-05	5	68	2	19011160
Pubmed	Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins.	ESYT2 RETREG2 MBOAT7 WFS1 PIEZO1 ARHGAP35 GPAT4	5.47e-05	499	68	7	22810586
Pubmed	Membrane depolarization causes a direct activation of G protein-coupled receptors leading to local Ca2+ release in smooth muscle.	RYR1 RYR2	5.62e-05	6	68	2	19549818
Pubmed	Rectification of muscle and nerve deficits in paralyzed ryanodine receptor type 1 mutant embryos.	RYR1 RYR2	5.62e-05	6	68	2	26025922
Pubmed	Roles of I(f) and intracellular Ca2+ release in spontaneous activity of ventricular cardiomyocytes during murine embryonic development.	RYR1 RYR2	5.62e-05	6	68	2	23463619
Pubmed	FKBP12.6 and cADPR regulation of Ca2+ release in smooth muscle cells.	RYR1 RYR2	5.62e-05	6	68	2	14592808
Pubmed	A calcium-induced calcium release mechanism supports luteinizing hormone-induced testosterone secretion in mouse Leydig cells.	RYR1 RYR2	5.62e-05	6	68	2	20519450
Pubmed	Essential Roles of Intracellular Calcium Release Channels in Muscle, Brain, Metabolism, and Aging.	RYR1 RYR2	5.62e-05	6	68	2	25966694
Pubmed	HIV-1 Tat activates neuronal ryanodine receptors with rapid induction of the unfolded protein response and mitochondrial hyperpolarization.	RYR1 RYR2	5.62e-05	6	68	2	19009018
Pubmed	Steroidogenic enzymes and stem cell markers are upregulated during androgen deprivation in prostate cancer.	UGT2B15 UGT2B17	5.62e-05	6	68	2	21365123
Pubmed	IP3Rs are sufficient for dendritic cell Ca2+ signaling in the absence of RyR1.	RYR1 RYR2	5.62e-05	6	68	2	16844763
Pubmed	Developmental expression of the calcium release channels during early neurogenesis of the mouse cerebral cortex.	RYR1 RYR2	7.86e-05	7	68	2	11860456
Pubmed	Weak activity of UDP-glucuronosyltransferase toward Bisphenol analogs in mouse perinatal development.	UGT2B15 UGT2B17	7.86e-05	7	68	2	26074487
Pubmed	Human immunodeficiency virus-1 Tat activates calpain proteases via the ryanodine receptor to enhance surface dopamine transporter levels and increase transporter-specific uptake and Vmax.	RYR1 RYR2	7.86e-05	7	68	2	20962236
Pubmed	Hetero-oligomer formation of mouse UDP-glucuronosyltransferase (UGT) 2b1 and 1a1 results in the gain of glucuronidation activity towards morphine, an activity which is absent in homo-oligomers of either UGT.	UGT2B15 UGT2B17	1.05e-04	8	68	2	32093886
Pubmed	Roles of IP3R and RyR Ca2+ channels in endoplasmic reticulum stress and beta-cell death.	RYR1 RYR2	1.05e-04	8	68	2	19033399
Pubmed	Simultaneous evaluation of six human glucuronidation activities in liver microsomes using liquid chromatography-tandem mass spectrometry.	UGT2B15 UGT2B17	1.05e-04	8	68	2	22579593
Pubmed	Sequential docking, molecular differentiation, and positioning of T-Tubule/SR junctions in developing mouse skeletal muscle.	RYR1 RYR2	1.05e-04	8	68	2	11784029
Pubmed	The configuration of the 17-hydroxy group variably influences the glucuronidation of beta-estradiol and epiestradiol by human UDP-glucuronosyltransferases.	UGT2B15 UGT2B17	1.05e-04	8	68	2	18719240
Pubmed	Associations between polymorphisms in glucuronidation and sulfation enzymes and mammographic breast density in premenopausal women in the United States.	UGT2B15 UGT2B17	1.05e-04	8	68	2	20142249
Pubmed	AAV-mediated intramuscular delivery of myotubularin corrects the myotubular myopathy phenotype in targeted murine muscle and suggests a function in plasma membrane homeostasis.	RYR1 RYR2	1.68e-04	10	68	2	18434328
Pubmed	ACMG recommendations for reporting of incidental findings in clinical exome and genome sequencing.	TSC2 RYR1 RYR2	1.94e-04	57	68	3	23788249
Pubmed	Role of UDP-glucuronosyltransferase isoforms in 13-cis retinoic acid metabolism in humans.	UGT2B15 UGT2B17	2.45e-04	12	68	2	20308471
Pubmed	New molecular components supporting ryanodine receptor-mediated Ca(2+) release: roles of junctophilin and TRIC channel in embryonic cardiomyocytes.	RYR1 RYR2	2.45e-04	12	68	2	19095005
Pubmed	Brn3a and Nurr1 mediate a gene regulatory pathway for habenula development.	SCN8A RTN4RL2 SDC2 CHRNB3	3.21e-04	166	68	4	19906978
Pubmed	A directed protein interaction network for investigating intracellular signal transduction.	TMX2 RETREG2 SBF1 MBOAT7 WFS1 PDS5A TSC2 NR4A1 SNAPC4	3.32e-04	1124	68	9	21900206
Pubmed	MED12 regulates a transcriptional network of calcium-handling genes in the heart.	RYR1 RYR2	3.38e-04	14	68	2	28724790
Interaction	OPALIN interactions	AGPAT5 SBF1 MBOAT7 WFS1 PDS5A TSC2 UBE3C GPAT4	2.78e-07	209	63	8	int:OPALIN
Interaction	STARD3NL interactions	AGPAT5 MBOAT7 WFS1 GPAT4	2.10e-05	52	63	4	int:STARD3NL
Cytoband	4q13	UGT2B15 UGT2B17	2.31e-04	15	69	2	4q13
Cytoband	7q36.3	ESYT2 UBE3C	6.01e-04	24	69	2	7q36.3
GeneFamily	Ryanodine receptors\|Protein phosphatase 1 regulatory subunits	RYR1 RYR2	2.34e-05	3	51	2	287
GeneFamily	1-acylglycerol-3-phosphate O-acyltransferases	AGPAT5 GPAT4	4.22e-04	11	51	2	46
Drug	Ryanodine	NR4A1 RYR1 RYR2	5.50e-06	12	68	3	ctd:D012433
Drug	(+)-Isoproterenol (+)-bitartrate salt [14638-70-1]; Up 200; 11uM; PC3; HT_HG-U133A	ABCG4 CXCR3 ATP9B HTR3B HSD17B1 RYR1	1.74e-05	182	68	6	6663_UP
Drug	Androstane-3,17-diol	UGT2B15 UGT2B17 NR1I3	2.01e-05	18	68	3	ctd:D015113
Drug	2-hydroxycarbazole	RYR1 RYR2	2.63e-05	3	68	2	CID000093551
Drug	cis-diammineplatinum(II	RYR1 RYR2	2.63e-05	3	68	2	CID000159790
Drug	2-hydroxyheptanoic acid	RYR1 RYR2	2.63e-05	3	68	2	CID002750949
Drug	Ryanodyl 3-(pyridine-3-carboxylate	RYR1 RYR2	2.63e-05	3	68	2	CID005748312
Drug	8N3-cADPR	RYR1 RYR2	2.63e-05	3	68	2	CID000127713
Drug	aminodantrolene	RYR1 RYR2	2.63e-05	3	68	2	CID009570289
Drug	MK-886; Down 200; 1uM; MCF7; HG-U133A	ABCG4 VIPR1 SBF1 PDS5A TMEM39A NR4A1	2.72e-05	197	68	6	601_DN
Drug	2,2',3,5',6-pentachlorobiphenyl	NR1I3 RYR1 RYR2	2.80e-05	20	68	3	ctd:C032904
Drug	Piribedil hydrochloride [78213-63-5]; Up 200; 12uM; PC3; HT_HG-U133A	SBF1 KCND3 HSD17B1 ARHGAP35 SDC2 RYR2	2.97e-05	200	68	6	6333_UP
Drug	PCB74	RYR1 RYR2	5.25e-05	4	68	2	CID000036218
Drug	148504-47-6	RYR1 RYR2	5.25e-05	4	68	2	CID006444275
Drug	SC 38249	RYR1 RYR2	5.25e-05	4	68	2	CID000134834
Drug	AC1L1U7A	RYR1 RYR2	5.25e-05	4	68	2	CID000035682
Disease	congenital myopathy 1A (implicated_via_orthology)	RYR1 RYR2	1.39e-05	3	64	2	DOID:3529 (implicated_via_orthology)
Disease	malignant hyperthermia (implicated_via_orthology)	RYR1 RYR2	1.39e-05	3	64	2	DOID:8545 (implicated_via_orthology)
Disease	cholic acid glucuronide measurement	UGT2B15 UGT2B17	1.39e-05	3	64	2	EFO_0800574
Disease	X-25937 measurement	UGT2B15 UGT2B17	2.77e-05	4	64	2	EFO_0800937
Disease	X-24574 measurement	UGT2B15 UGT2B17	9.66e-05	7	64	2	EFO_0800897
Disease	deoxycholic acid glucuronide measurement	UGT2B15 UGT2B17	1.29e-04	8	64	2	EFO_0800575
Disease	obsolete_red blood cell distribution width	GPR158 HECW2 PIEZO1 TMC8 UGT2B15 SLC15A5 PDS5A AK9 TIPRL NR1I3 CHRNB3	1.38e-04	1347	64	11	EFO_0005192
Disease	4-androsten-3alpha,17alpha-diol monosulfate (3) measurement	UGT2B15 UGT2B17	2.06e-04	10	64	2	EFO_0022090
Disease	DNA repair protein RAD51 homolog 4 measurement	UGT2B15 UGT2B17	2.52e-04	11	64	2	EFO_0801531
Disease	5alpha-androstan-3beta,17beta-diol monosulfate (2) measurement	UGT2B15 UGT2B17	3.01e-04	12	64	2	EFO_0800291
Disease	androstenediol (3alpha, 17alpha) monosulfate (3) measurement	UGT2B15 UGT2B17	3.56e-04	13	64	2	EFO_0800293
Disease	X-19141 measurement	UGT2B15 UGT2B17	3.56e-04	13	64	2	EFO_0800799
Disease	5alpha-androstan-3alpha,17alpha-diol monosulfate measurement	UGT2B15 UGT2B17	4.14e-04	14	64	2	EFO_0800283
Disease	depressive disorder (is_implicated_in)	HTR3B CHRNB3	6.17e-04	17	64	2	DOID:1596 (is_implicated_in)
Disease	sweet liking measurement	KISS1R TMEM63C	6.93e-04	18	64	2	EFO_0010156
Disease	5alpha-androstan-3alpha,17beta-diol monosulfate (1) measurement	UGT2B15 UGT2B17	6.93e-04	18	64	2	EFO_0800288
Disease	etiocholanolone glucuronide measurement	UGT2B15 UGT2B17	7.73e-04	19	64	2	EFO_0800362
Disease	androsterone glucuronide measurement	UGT2B15 UGT2B17	8.58e-04	20	64	2	EFO_0800317
Disease	alcohol use disorder (implicated_via_orthology)	VIPR1 RYR1 CHRNB3 RYR2	8.62e-04	195	64	4	DOID:1574 (implicated_via_orthology)
Disease	X-24947 measurement	UGT2B15 UGT2B17	1.04e-03	22	64	2	EFO_0800910
Disease	lymphocyte count, response to vaccine	HECW2 PXMP2	1.04e-03	22	64	2	EFO_0004587, EFO_0004645
Disease	West Syndrome	PIGA TSC2	1.24e-03	24	64	2	C0037769
Disease	metabolite measurement	MBOAT7 PXMP2 UGT2B15 UGT2B17 WDFY4 SLC36A2	1.34e-03	560	64	6	EFO_0004725
Disease	epiandrosterone sulfate measurement	UGT2B15 UGT2B17	1.35e-03	25	64	2	EFO_0021120
Disease	obsessive-compulsive symptom measurement	TMTC1 TMEM63C	2.07e-03	31	64	2	EFO_0007802

Protein segments in the cluster

Peptide	Gene	Start	Entry
FDRAFLPALYSLLFL	CXCR3	51	P49682
LARSFALLLPVYALG	ESYT2	116	A0FGR8
SFVLRRLPLFYTLFL	CHRNB3	226	Q05901
LVLGIFFLALRLLAY	ABCG4	621	Q9H172
LVLLSRFDRLLFQSY	HTR3B	406	O95264
YFLGFLLLAARLPLD	GPNMB	6	Q14956
LFEYRARRFLSLPST	CAMTA2	611	O94983
RARLGLYIFARVSLF	AQR	1296	O60306
LQRFYHRLLRPLSLF	CCDC87	11	Q9NVE4
PRRSLLAALFFFSLS	B4GALT5	11	O43286
AAFRGLSRLTILYLF	RTN4RL2	221	Q86UN3
YLPLALHLASEFFLR	PDS5A	66	Q29RF7
LLRIPAFSRDLYLLL	ADAMTS19	166	Q8TE59
RRPLFRSCFILLPYL	TIPARP	401	Q7Z3E1
SAFLELFILRLAYRS	NR4A1	441	P22736
AFFTRPFYKALLRIL	HECW2	1326	Q9P2P5
RPRDRFLYAKLLGLL	NR1I3	306	Q14994
ILLLPFLAILASYAR	OR2AK2	221	Q8NG84
YLLRLFAAPSRYRFI	KCND3	241	Q9UK17
ILYFEPSTFRCILLR	GPR158	471	Q5T848
RFLLLFSYIIPISLR	ATP9B	411	O43861
RPLLLLAYFSRLCAK	IL17RE	586	Q8NFR9
LLRLGSLFCYSTRLF	TMEM63C	561	Q9P1W3
RELQPFLFLTFSLLY	OR4K15	21	Q8NH41
PSRALERAFALYNLL	KISS1R	196	Q969F8
SYLLFFRALSLLGLP	MBOAT7	81	Q96N66
CRGLLALLFPLRYSF	SBF1	251	O95248
RPLFVLFLLLYVASL	OR1K1	26	Q8NGR3
LEAVRLPFVRRFYLL	KLHL21	221	Q9UJP4
RYCFLLPLRIALAFT	GPAT4	171	Q86UL3
LPLQRSAARLLFSFY	FCRLA	196	Q7L513
TLRYFTTERFLPLLR	HSD17B1	251	P14061
RLLLYVRASPLFYES	IDI2-AS1	91	Q9NZ38
ASRALRLAPFVYLLL	HEPACAM	11	Q14CZ8
GFLFAIFLILLLVYR	SDC2	156	P34741
FLTLLPLFIFQLLYR	SLC15A5	306	A6NIM6
LSRNFYTLRFLALFL	RYR1	4556	P21817
TLARDLYAFYPLLIR	RYR2	3361	Q92736
FPFLSIRRSALLYIA	AK9	1826	Q5TCS8
LSLRYDLTVPFARYL	HARS2	126	P49590
LRPFFLLSVSLLAYF	RETREG2	101	Q8NC44
FGLAALYAPVLLLRA	SFT2D3	91	Q587I9
LYAPVLLLRARKFAL	SFT2D3	96	Q587I9
SRLYMLSFLPFLVLL	SLC36A2	201	Q495M3
ILLFLAFLLLFLYRR	SMIM28	61	A0A1B0GU29
EFLLSLRYFRIFIAL	SMIM7	46	Q9BQ49
LYLKFRLPEISRFSA	PROS1	311	P07225
RRKLYLAALPLAFEA	ARHGAP35	336	Q9NRY4
NRRVLYAATFLLFPL	STRA6	506	Q9BX79
LCYLLLPATRLFRAL	ANGEL1	6	Q9UNK9
LFHSLPLLRYIFVRE	PIGA	106	P37287
YLLSALLSAAFLLVR	TMX2	26	Q9Y320
YSRLARSTLLLIPLF	VIPR1	336	P32241
IRSYFTFLRFLLLLN	TMC8	106	Q8IU68
LACLLFLLAFLSYNR	TMTC1	171	Q8IUR5
ALPRRALAQYLLFLR	PXMP2	16	Q9NR77
PSSFFLLLRFFLRID	TIPRL	176	O75663
YFLFHRPLRLLNLLI	TMEM39A	411	Q9NV64
PCYLILTLLRFSFDL	USP35	801	Q9P2H5
LLLYFLASPSLRTRF	WDFY4	1646	Q6ZS81
ALYILSPFNLIRRIA	SCN8A	111	Q9UQD0
YLLLRARFLAAFTLP	SNAPC4	1361	Q5SXM2
RFSGLSLVYLLFLLL	PIEZO1	26	Q92508
LAELFNIPFLYSLRF	UGT2B15	161	P54855
RLLSAFLPARFYQAL	AGPAT5	36	Q9NUQ2
LAELLNIPFLYSLRF	UGT2B17	161	O75795
FLSTLARLPHLYRNF	TSC2	846	P49815
PKVRLLYSLAFNARF	UBE3C	441	Q15386
VYSPLALRRLTAFLE	ZAR1	181	Q86SH2
LLRASIGYFLFLFAL	WFS1	556	O76024