Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionSUMO ligase activity

RGPD4 RGPD8 RGPD3

1.35e-0520473GO:0061665
GeneOntologyMolecularFunctionglutamate receptor activity

GRIK2 GRIK4 GRM4

3.44e-0527473GO:0008066
GeneOntologyMolecularFunctionkainate selective glutamate receptor activity

GRIK2 GRIK4

8.09e-056472GO:0015277
GeneOntologyMolecularFunctionSUMO transferase activity

RGPD4 RGPD8 RGPD3

8.26e-0536473GO:0019789
GeneOntologyMolecularFunctionpeptidyl-prolyl cis-trans isomerase activity

RGPD4 RGPD8 RGPD3

2.22e-0450473GO:0003755
GeneOntologyMolecularFunctioncis-trans isomerase activity

RGPD4 RGPD8 RGPD3

2.64e-0453473GO:0016859
GeneOntologyMolecularFunctionglutamate-gated receptor activity

GRIK2 GRIK4

7.21e-0417472GO:0004970
GeneOntologyMolecularFunctionligand-gated sodium channel activity

GRIK2 GRIK4

8.10e-0418472GO:0015280
GeneOntologyMolecularFunctionligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential

GRIK2 GRIK4

1.45e-0324472GO:0099507
GeneOntologyMolecularFunctionmRNA 3'-UTR AU-rich region binding

AGO2 APOBEC1

2.11e-0329472GO:0035925
GeneOntologyMolecularFunctionubiquitin-like protein ligase activity

RGPD4 UBR2 RGPD8 RGPD3 UBR3

2.37e-03398475GO:0061659
GeneOntologyBiologicalProcessNLS-bearing protein import into nucleus

RGPD4 RGPD8 RGPD3 RGPD5

1.12e-0720474GO:0006607
GeneOntologyBiologicalProcesspositive regulation of glucokinase activity

RGPD4 RGPD8 RGPD3

9.23e-079473GO:0033133
GeneOntologyBiologicalProcesspositive regulation of hexokinase activity

RGPD4 RGPD8 RGPD3

1.32e-0610473GO:1903301
GeneOntologyBiologicalProcessregulation of glucokinase activity

RGPD4 RGPD8 RGPD3

3.12e-0613473GO:0033131
GeneOntologyBiologicalProcessregulation of hexokinase activity

RGPD4 RGPD8 RGPD3

3.97e-0614473GO:1903299
GeneOntologyBiologicalProcessubiquitin-dependent protein catabolic process via the N-end rule pathway

UBR2 UBR3

3.04e-054472GO:0071596
GeneOntologyBiologicalProcesspositive regulation of blood-brain barrier permeability

ANGPT1 TJP3

5.06e-055472GO:1905605
GeneOntologyBiologicalProcessprotein import into nucleus

RGPD4 ANGPT1 RGPD8 RGPD3 RGPD5

7.97e-05195475GO:0006606
GeneOntologyBiologicalProcessprotein peptidyl-prolyl isomerization

RGPD4 RGPD8 RGPD3

8.85e-0538473GO:0000413
GeneOntologyBiologicalProcessimport into nucleus

RGPD4 ANGPT1 RGPD8 RGPD3 RGPD5

9.20e-05201475GO:0051170
GeneOntologyBiologicalProcessprotein localization to nucleus

RGPD4 ANGPT1 RGPD8 SYNE1 RGPD3 RGPD5

1.64e-04362476GO:0034504
GeneOntologyBiologicalProcessregulation of blood-brain barrier permeability

ANGPT1 TJP3

2.26e-0410472GO:1905603
GeneOntologyBiologicalProcesssynaptic transmission, glutamatergic

CCR2 GRIK2 GRIK4 GRM4

2.31e-04132474GO:0035249
GeneOntologyBiologicalProcesspeptidyl-proline modification

RGPD4 RGPD8 RGPD3

2.54e-0454473GO:0018208
GeneOntologyBiologicalProcessglutamate receptor signaling pathway

GRIK2 GRIK4 GRM4

3.30e-0459473GO:0007215
GeneOntologyCellularComponentcytoplasmic periphery of the nuclear pore complex

RGPD4 RGPD8 RGPD3

6.31e-078483GO:1990723
GeneOntologyCellularComponentnuclear pore cytoplasmic filaments

RGPD4 RGPD8 RGPD3

1.35e-0610483GO:0044614
GeneOntologyCellularComponentannulate lamellae

RGPD4 RGPD8 RGPD3

4.06e-0614483GO:0005642
GeneOntologyCellularComponentnuclear pore nuclear basket

RGPD4 RGPD8 RGPD3

9.05e-0618483GO:0044615
GeneOntologyCellularComponentnuclear inclusion body

RGPD4 RGPD8 RGPD3

1.26e-0520483GO:0042405
GeneOntologyCellularComponentSUMO ligase complex

RGPD4 RGPD8 RGPD3

1.47e-0521483GO:0106068
GeneOntologyCellularComponentkainate selective glutamate receptor complex

GRIK2 GRIK4

7.70e-056482GO:0032983
GeneOntologyCellularComponentnuclear pore

RGPD4 RGPD8 RGPD3 RGPD5

8.48e-05101484GO:0005643
GeneOntologyCellularComponentperikaryon

CCR2 DDN GRIK2 GRIK4 CTSL

1.56e-04223485GO:0043204
GeneOntologyCellularComponentdendrite

CCR2 AGO2 SYNE1 DDN GRIK2 GRIK4 TANC1 GRM4

6.84e-04858488GO:0030425
GeneOntologyCellularComponentdendritic tree

CCR2 AGO2 SYNE1 DDN GRIK2 GRIK4 TANC1 GRM4

6.95e-04860488GO:0097447
GeneOntologyCellularComponentinclusion body

RGPD4 RGPD8 RGPD3

1.16e-0390483GO:0016234
GeneOntologyCellularComponentperinuclear region of cytoplasm

ANKRD13D RGPD4 CCR2 RGPD8 SYNE1 RGPD3 HMBS CTSL

1.19e-03934488GO:0048471
GeneOntologyCellularComponentaxon terminus

GRIK2 GRIK4 TANC1 GRM4

1.36e-03210484GO:0043679
GeneOntologyCellularComponentterminal bouton

GRIK2 GRIK4 GRM4

1.40e-0396483GO:0043195
GeneOntologyCellularComponentcytoplasmic stress granule

AGO2 HIPK2 PABPC5

1.40e-0396483GO:0010494
GeneOntologyCellularComponentsomatodendritic compartment

CCR2 AGO2 SYNE1 DDN GRIK2 GRIK4 TANC1 GRM4 CTSL

1.70e-031228489GO:0036477
GeneOntologyCellularComponentneuron projection terminus

GRIK2 GRIK4 TANC1 GRM4

1.99e-03233484GO:0044306
GeneOntologyCellularComponentsodium channel complex

GRIK2 GRIK4

2.01e-0329482GO:0034706
GeneOntologyCellularComponentendoribonuclease complex

AGO2 TSEN2

3.27e-0337482GO:1902555
GeneOntologyCellularComponentcytoplasmic ribonucleoprotein granule

AGO2 SYNE1 HIPK2 PABPC5

3.35e-03269484GO:0036464
GeneOntologyCellularComponentribonucleoprotein granule

AGO2 SYNE1 HIPK2 PABPC5

4.21e-03287484GO:0035770
GeneOntologyCellularComponentendonuclease complex

AGO2 TSEN2

4.39e-0343482GO:1905348
GeneOntologyCellularComponentionotropic glutamate receptor complex

GRIK2 GRIK4

4.80e-0345482GO:0008328
GeneOntologyCellularComponentneurotransmitter receptor complex

GRIK2 GRIK4

5.90e-0350482GO:0098878
MousePhenoelevated level of mitotic sister chromatid exchange

RGPD4 RGPD8 RGPD3

1.01e-0516383MP:0003701
MousePhenoincreased hepatocellular carcinoma incidence

RGPD4 RGPD8 RGPD3 PSMB9

3.74e-0570384MP:0003331
MousePhenoabnormal morula morphology

RGPD4 RGPD8 RGPD3

4.61e-0526383MP:0012058
MousePhenodecreased tumor latency

RGPD4 RGPD8 RGPD3

7.15e-0530383MP:0010308
MousePhenofailure of blastocyst formation

RGPD4 RGPD8 RGPD3

7.90e-0531383MP:0012129
MousePhenoabnormal tumor latency

RGPD4 RGPD8 RGPD3

1.05e-0434383MP:0010307
MousePhenoabnormal blastocyst formation

RGPD4 RGPD8 RGPD3

1.58e-0439383MP:0012128
MousePhenoincreased sarcoma incidence

RGPD4 RGPD8 RGPD3 PSMB9

1.63e-04102384MP:0002032
MousePhenoincreased lung tumor incidence

RGPD4 RGPD8 RGPD3 PSMB9

1.96e-04107384MP:0008014
MousePhenoincreased respiratory system tumor incidence

RGPD4 RGPD8 RGPD3 PSMB9

1.96e-04107384MP:0010298
MousePhenoincreased liver tumor incidence

RGPD4 RGPD8 RGPD3 PSMB9

2.26e-04111384MP:0008019
MousePhenoincreased hepatobiliary system tumor incidence

RGPD4 RGPD8 RGPD3 PSMB9

2.26e-04111384MP:0010297
MousePhenoabnormal mitosis

RGPD4 RGPD8 RGPD3 SPART

3.89e-04128384MP:0004046
MousePhenoabnormal cell cycle

RGPD4 UBR2 RGPD8 RGPD3 HIPK2 SPART TEX11

4.38e-04520387MP:0003077
MousePhenoaneuploidy

RGPD4 RGPD8 RGPD3

5.98e-0461383MP:0004024
DomainGrip

RGPD4 RGPD8 RGPD3 RGPD5

1.25e-0811484SM00755
DomainGRIP

RGPD4 RGPD8 RGPD3 RGPD5

1.25e-0811484PF01465
DomainRan_BP1

RGPD4 RGPD8 RGPD3 RGPD5

1.87e-0812484PF00638
DomainGRIP_dom

RGPD4 RGPD8 RGPD3 RGPD5

1.87e-0812484IPR000237
DomainGRIP

RGPD4 RGPD8 RGPD3 RGPD5

1.87e-0812484PS50913
DomainRANBD1

RGPD4 RGPD8 RGPD3 RGPD5

1.87e-0812484PS50196
DomainRanBD

RGPD4 RGPD8 RGPD3 RGPD5

2.70e-0813484SM00160
DomainRan_bind_dom

RGPD4 RGPD8 RGPD3 RGPD5

2.70e-0813484IPR000156
DomainGCC2_Rab_bind

RGPD4 RGPD8 RGPD3

5.54e-077483IPR032023
DomainRab_bind

RGPD4 RGPD8 RGPD3

5.54e-077483PF16704
Domain-

RGPD4 RGPD8 RGPD3

1.89e-06104831.10.220.60
DomainTPR-like_helical_dom

RGPD4 RGPD8 COPE RGPD3 TANC1 TEX11 RGPD5

2.05e-06233487IPR011990
Domain-

RGPD4 RGPD8 COPE RGPD3 TANC1 TEX11

1.44e-052074861.25.40.10
DomainTPR

RGPD4 RGPD8 RGPD3 TANC1 TEX11

1.96e-05129485SM00028
DomainTPR_repeat

RGPD4 RGPD8 RGPD3 TANC1 TEX11

2.27e-05133485IPR019734
DomainTPR-contain_dom

RGPD4 RGPD8 RGPD3 TANC1 RGPD5

4.05e-05150485IPR013026
DomainTPR_REGION

RGPD4 RGPD8 RGPD3 TANC1 RGPD5

6.38e-05165485PS50293
DomainTPR

RGPD4 RGPD8 RGPD3 TANC1 RGPD5

6.38e-05165485PS50005
DomainANF_lig-bd_rcpt

GRIK2 GRIK4 GRM4

1.16e-0437483IPR001828
DomainANF_receptor

GRIK2 GRIK4 GRM4

1.16e-0437483PF01094
DomainZF_UBR

UBR2 UBR3

1.35e-047482PS51157
Domainzf-UBR

UBR2 UBR3

1.35e-047482PF02207
DomainZnf_UBR

UBR2 UBR3

1.35e-047482IPR003126
DomainZnF_UBR1

UBR2 UBR3

1.35e-047482SM00396
DomainPeripla_BP_I

GRIK2 GRIK4 GRM4

1.36e-0439483IPR028082
DomainIontro_rcpt

GRIK2 GRIK4

9.64e-0418482IPR001320
DomainLig_chan-Glu_bd

GRIK2 GRIK4

9.64e-0418482PF10613
DomainIono_rcpt_met

GRIK2 GRIK4

9.64e-0418482IPR001508
DomainGlu/Gly-bd

GRIK2 GRIK4

9.64e-0418482IPR019594
DomainLig_chan-Glu_bd

GRIK2 GRIK4

9.64e-0418482SM00918
DomainLig_chan

GRIK2 GRIK4

9.64e-0418482PF00060
DomainPBPe

GRIK2 GRIK4

9.64e-0418482SM00079
DomainTHIOL_PROTEASE_CYS

CTSL CAPN11

2.02e-0326482PS00139
DomainTHIOL_PROTEASE_ASN

CTSL CAPN11

2.18e-0327482PS00640
DomainTHIOL_PROTEASE_HIS

CTSL CAPN11

2.18e-0327482PS00639
DomainPept_cys_AS

CTSL CAPN11

2.34e-0328482IPR000169
DomainPH_dom-like

RGPD4 RGPD8 RGPD3 PLCD4 RGPD5

4.61e-03426485IPR011993
PathwayREACTOME_TRANSCRIPTIONAL_REGULATION_BY_SMALL_RNAS

RGPD4 AGO2 RGPD8 RGPD3

2.09e-0641324MM15200
PathwayREACTOME_GENE_SILENCING_BY_RNA

RGPD4 AGO2 RGPD8 RGPD3

4.31e-0649324MM14837
PathwayBIOCARTA_RANBP2_PATHWAY

RGPD4 RGPD8 RGPD3

8.47e-0618323MM1549
PathwayREACTOME_NUCLEAR_PORE_COMPLEX_NPC_DISASSEMBLY

RGPD4 RGPD8 RGPD3

9.92e-0540323MM14945
PathwayREACTOME_SUMOYLATION_OF_SUMOYLATION_PROTEINS

RGPD4 RGPD8 RGPD3

1.15e-0442323MM15039
PathwayREACTOME_TRANSPORT_OF_THE_SLBP_DEPENDANT_MATURE_MRNA

RGPD4 RGPD8 RGPD3

1.23e-0443323MM14609
PathwayREACTOME_SUMOYLATION_OF_UBIQUITINYLATION_PROTEINS

RGPD4 RGPD8 RGPD3

1.61e-0447323MM14939
PathwayREACTOME_TRANSPORT_OF_MATURE_MRNAS_DERIVED_FROM_INTRONLESS_TRANSCRIPTS

RGPD4 RGPD8 RGPD3

1.94e-0450323MM14610
PathwayREACTOME_SUMOYLATION_OF_DNA_REPLICATION_PROTEINS

RGPD4 RGPD8 RGPD3

2.05e-0451323MM15151
PathwayREACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS

GRIK2 GRIK4

2.22e-0410322M10272
PathwayREACTOME_NUCLEAR_ENVELOPE_BREAKDOWN

RGPD4 RGPD8 RGPD3

2.57e-0455323MM14917
PathwayREACTOME_SUMOYLATION_OF_RNA_BINDING_PROTEINS

RGPD4 RGPD8 RGPD3

3.01e-0458323MM15149
PathwayREACTOME_SNRNP_ASSEMBLY

RGPD4 RGPD8 RGPD3

3.01e-0458323MM14736
PathwayREACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS

GRIK2 GRIK4

3.25e-0412322MM15142
PathwayREACTOME_SUMOYLATION_OF_CHROMATIN_ORGANIZATION_PROTEINS

RGPD4 RGPD8 RGPD3

4.22e-0465323MM15147
PathwayREACTOME_SUMOYLATION

RGPD4 RGPD8 RGPD3 HIPK2

5.52e-04169324MM14919
PathwayREACTOME_REGULATION_OF_HSF1_MEDIATED_HEAT_SHOCK_RESPONSE

RGPD4 RGPD8 RGPD3

5.93e-0473323MM14948
PathwayREACTOME_GLUCOSE_METABOLISM

RGPD4 RGPD8 RGPD3

8.33e-0482323MM15394
PathwayREACTOME_SUMOYLATION_OF_DNA_DAMAGE_RESPONSE_AND_REPAIR_PROTEINS

RGPD4 RGPD8 RGPD3

8.94e-0484323MM14929
PathwayREACTOME_TRANSPORT_OF_MATURE_TRANSCRIPT_TO_CYTOPLASM

RGPD4 RGPD8 RGPD3

9.57e-0486323MM15413
PathwayREACTOME_CELLULAR_RESPONSE_TO_HEAT_STRESS

RGPD4 RGPD8 RGPD3

1.16e-0392323MM14951
PathwayREACTOME_AMPLIFICATION_OF_SIGNAL_FROM_THE_KINETOCHORES

RGPD4 RGPD8 RGPD3

1.48e-03100323MM14561
PathwayREACTOME_TRANSCRIPTIONAL_REGULATION_BY_RUNX1

AGO2 PSMB9 HIPK2 CTSL

1.93e-03237324M27786
PathwayREACTOME_ACTIVATION_OF_KAINATE_RECEPTORS_UPON_GLUTAMATE_BINDING

GRIK2 GRIK4

2.09e-0330322M18193
PathwayREACTOME_MITOTIC_PROPHASE

RGPD4 RGPD8 RGPD3

2.15e-03114323MM15361
PathwayREACTOME_MITOTIC_SPINDLE_CHECKPOINT

RGPD4 RGPD8 RGPD3

2.32e-03117323MM15387
PathwayREACTOME_ACTIVATION_OF_KAINATE_RECEPTORS_UPON_GLUTAMATE_BINDING

GRIK2 GRIK4

2.37e-0332322MM15143
PathwayREACTOME_REGULATION_OF_MECP2_EXPRESSION_AND_ACTIVITY

AGO2 HIPK2

2.37e-0332322M27900
PathwayREACTOME_RESOLUTION_OF_SISTER_CHROMATID_COHESION

RGPD4 RGPD8 RGPD3

3.06e-03129323MM14894
PathwayREACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS

TAS2R10 GRM4

3.16e-0337322MM15067
PathwayREACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS

TAS2R10 GRM4

3.51e-0339322M793
Pubmed

Complex genomic rearrangements lead to novel primate gene function.

RGPD4 RGPD8 RGPD3 RGPD5

1.21e-10749415710750
Pubmed

Microglial activation in an amyotrophic lateral sclerosis-like model caused by Ranbp2 loss and nucleocytoplasmic transport impairment in retinal ganglion neurons.

RGPD4 RGPD8 RGPD3

9.16e-08749330944974
Pubmed

Nucleoporin Nup358 drives the differentiation of myeloid-biased multipotent progenitors by modulating HDAC3 nuclear translocation.

RGPD4 RGPD8 RGPD3

9.16e-08749338838144
Pubmed

Nup358, a nucleoporin, functions as a key determinant of the nuclear pore complex structure remodeling during skeletal myogenesis.

RGPD4 RGPD8 RGPD3

9.16e-08749321205196
Pubmed

Haploinsufficiency of RanBP2 is neuroprotective against light-elicited and age-dependent degeneration of photoreceptor neurons.

RGPD4 RGPD8 RGPD3

9.16e-08749318949001
Pubmed

Selective impairment of a subset of Ran-GTP-binding domains of ran-binding protein 2 (Ranbp2) suffices to recapitulate the degeneration of the retinal pigment epithelium (RPE) triggered by Ranbp2 ablation.

RGPD4 RGPD8 RGPD3

9.16e-08749325187515
Pubmed

Interconversion of red opsin isoforms by the cyclophilin-related chaperone protein Ran-binding protein 2.

RGPD4 RGPD8 RGPD3

9.16e-0874939037092
Pubmed

Kinesin-1 and mitochondrial motility control by discrimination of structurally equivalent but distinct subdomains in Ran-GTP-binding domains of Ran-binding protein 2.

RGPD4 RGPD8 RGPD3

9.16e-08749323536549
Pubmed

Localization of the Ran-GTP binding protein RanBP2 at the cytoplasmic side of the nuclear pore complex.

RGPD4 RGPD8 RGPD3

9.16e-0874938603673
Pubmed

Retina-specifically expressed novel subtypes of bovine cyclophilin.

RGPD4 RGPD8 RGPD3

9.16e-0874937559465
Pubmed

Uncoupling phototoxicity-elicited neural dysmorphology and death by insidious function and selective impairment of Ran-binding protein 2 (Ranbp2).

RGPD4 RGPD8 RGPD3

9.16e-08749326632511
Pubmed

Mst1, RanBP2 and eIF4G are new markers for in vivo PI3K activation in murine and human prostate.

RGPD4 RGPD8 RGPD3

9.16e-08749317372272
Pubmed

Differential loss of prolyl isomerase or chaperone activity of Ran-binding protein 2 (Ranbp2) unveils distinct physiological roles of its cyclophilin domain in proteostasis.

RGPD4 RGPD8 RGPD3

9.16e-08749324403063
Pubmed

Distinct and atypical intrinsic and extrinsic cell death pathways between photoreceptor cell types upon specific ablation of Ranbp2 in cone photoreceptors.

RGPD4 RGPD8 RGPD3

9.16e-08749323818861
Pubmed

Proteostatic Remodeling of Small Heat Shock Chaperones─Crystallins by Ran-Binding Protein 2─and the Peptidyl-Prolyl cis-trans Isomerase and Chaperone Activities of Its Cyclophilin Domain.

RGPD4 RGPD8 RGPD3

9.16e-08749338657106
Pubmed

Genomic organization, expression, and localization of murine Ran-binding protein 2 (RanBP2) gene.

RGPD4 RGPD8 RGPD3

9.16e-08749311353387
Pubmed

Identification of RanBP2- and kinesin-mediated transport pathways with restricted neuronal and subcellular localization.

RGPD4 RGPD8 RGPD3

9.16e-08749312191015
Pubmed

Ranbp2 haploinsufficiency mediates distinct cellular and biochemical phenotypes in brain and retinal dopaminergic and glia cells elicited by the Parkinsonian neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).

RGPD4 RGPD8 RGPD3

9.16e-08749322821000
Pubmed

Neuroprotection resulting from insufficiency of RANBP2 is associated with the modulation of protein and lipid homeostasis of functionally diverse but linked pathways in response to oxidative stress.

RGPD4 RGPD8 RGPD3

9.16e-08749320682751
Pubmed

The distribution of phosphorylated SR proteins and alternative splicing are regulated by RANBP2.

RGPD4 RGPD8 RGPD3

1.46e-07849322262462
Pubmed

The nucleoporin RanBP2 tethers the cAMP effector Epac1 and inhibits its catalytic activity.

RGPD4 RGPD8 RGPD3

1.46e-07849321670213
Pubmed

Zap70 and downstream RanBP2 are required for the exact timing of the meiotic cell cycle in oocytes.

RGPD4 RGPD8 RGPD3

1.46e-07849328745977
Pubmed

Critical role of RanBP2-mediated SUMOylation of Small Heterodimer Partner in maintaining bile acid homeostasis.

RGPD4 RGPD8 RGPD3

1.46e-07849327412403
Pubmed

Mice lacking Ran binding protein 1 are viable and show male infertility.

RGPD4 RGPD8 RGPD3

1.46e-07849321310149
Pubmed

The cyclophilin-like domain mediates the association of Ran-binding protein 2 with subunits of the 19 S regulatory complex of the proteasome.

RGPD4 RGPD8 RGPD3

2.19e-0794939733766
Pubmed

Loss of Ranbp2 in motoneurons causes disruption of nucleocytoplasmic and chemokine signaling, proteostasis of hnRNPH3 and Mmp28, and development of amyotrophic lateral sclerosis-like syndromes.

RGPD4 RGPD8 RGPD3

2.19e-07949328100513
Pubmed

Resolution of sister centromeres requires RanBP2-mediated SUMOylation of topoisomerase IIalpha.

RGPD4 RGPD8 RGPD3

2.19e-07949318394993
Pubmed

Impairments in age-dependent ubiquitin proteostasis and structural integrity of selective neurons by uncoupling Ran GTPase from the Ran-binding domain 3 of Ranbp2 and identification of novel mitochondrial isoforms of ubiquitin-conjugating enzyme E2I (ubc9) and Ranbp2.

RGPD4 RGPD8 RGPD3

2.19e-07949328877029
Pubmed

The docking of kinesins, KIF5B and KIF5C, to Ran-binding protein 2 (RanBP2) is mediated via a novel RanBP2 domain.

RGPD4 RGPD8 RGPD3

2.19e-07949311553612
Pubmed

Association of the kinesin-binding domain of RanBP2 to KIF5B and KIF5C determines mitochondria localization and function.

RGPD4 RGPD8 RGPD3

2.19e-07949317887960
Pubmed

The zinc finger cluster domain of RanBP2 is a specific docking site for the nuclear export factor, exportin-1.

RGPD4 RGPD8 RGPD3

2.19e-07949310601307
Pubmed

The RanBP2/RanGAP1*SUMO1/Ubc9 SUMO E3 ligase is a disassembly machine for Crm1-dependent nuclear export complexes.

RGPD4 RGPD8 RGPD3

3.13e-071049327160050
Pubmed

Parkin ubiquitinates and promotes the degradation of RanBP2.

RGPD4 RGPD8 RGPD3

3.13e-071049316332688
Pubmed

Cyclophilin-related protein RanBP2 acts as chaperone for red/green opsin.

RGPD4 RGPD8 RGPD3

3.13e-07104938857542
Pubmed

Ran-dependent docking of importin-beta to RanBP2/Nup358 filaments is essential for protein import and cell viability.

RGPD4 RGPD8 RGPD3

3.13e-071049321859863
Pubmed

An Rtn4/Nogo-A-interacting micropeptide modulates synaptic plasticity with age.

RGPD4 RGPD8 RGPD3

4.30e-071149335771867
Pubmed

RanBP2 modulates Cox11 and hexokinase I activities and haploinsufficiency of RanBP2 causes deficits in glucose metabolism.

RGPD4 RGPD8 RGPD3

4.30e-071149317069463
Pubmed

T-cell receptor (TCR) signaling promotes the assembly of RanBP2/RanGAP1-SUMO1/Ubc9 nuclear pore subcomplex via PKC-θ-mediated phosphorylation of RanGAP1.

RGPD4 RGPD8 RGPD3

4.30e-071149334110283
Pubmed

Ankyrin-G induces nucleoporin Nup358 to associate with the axon initial segment of neurons.

RGPD4 RGPD8 RGPD3

7.44e-071349331427429
Pubmed

Glutamatergic gene variants impact the clinical profile of efficacy and side effects of haloperidol.

GRIK2 GRIK4 GRM4

7.44e-071349320859245
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

RGPD4 AGO2 RGPD8 SYNE1 RGPD3 SAFB2 DDN GRIK2 GRM4 ITIH4

7.80e-07963491028671696
Pubmed

Limited expression of nuclear pore membrane glycoprotein 210 in cell lines and tissues suggests cell-type specific nuclear pores in metazoans.

RGPD4 RGPD8 RGPD3

1.18e-061549314697343
Pubmed

Terminal differentiation of cortical neurons rapidly remodels RanGAP-mediated nuclear transport system.

RGPD4 RGPD8 RGPD3

3.97e-062249327717094
Pubmed

Glutamate can act as a signaling molecule in mouse preimplantation embryos†.

GRIK2 GRIK4 GRM4

5.21e-062449335746896
Pubmed

Parent-of-origin effects of A1CF and AGO2 on testicular germ-cell tumors, testicular abnormalities, and fertilization bias.

AGO2 APOBEC1

5.83e-06349227582469
Pubmed

Distinct Subunit Domains Govern Synaptic Stability and Specificity of the Kainate Receptor.

GRIK2 GRIK4

5.83e-06349227346345
Pubmed

Mammalian microtubule P-body dynamics are mediated by nesprin-1.

AGO2 SYNE1

1.16e-05449224862572
Pubmed

Distribution of kainate receptor subunits at hippocampal mossy fiber synapses.

GRIK2 GRIK4

1.16e-05449212954862
Pubmed

Identification of a novel Ran binding protein 2 related gene (RANBP2L1) and detection of a gene cluster on human chromosome 2q11-q12.

RGPD8 RGPD5

1.16e-0544929480752
Pubmed

Tex19.1 inhibits the N-end rule pathway and maintains acetylated SMC3 cohesin and sister chromatid cohesion in oocytes.

UBR2 UBR3

1.16e-05449232232464
Pubmed

The human RNA kinase hClp1 is active on 3' transfer RNA exons and short interfering RNAs.

AGO2 TSEN2

1.16e-05449217495927
Pubmed

Developmental expression patterns of kainate receptors in the mouse spinal cord.

GRIK2 GRIK4

1.94e-05549223076118
Pubmed

Identification of the immunoproteasome as a novel regulator of skeletal muscle differentiation.

PSMB9 CTSL

1.94e-05549224164898
Pubmed

Determination of kainate receptor subunit ratios in mouse brain using novel chimeric protein standards.

GRIK2 GRIK4

1.94e-05549226448475
Pubmed

Biochemical and assembly properties of GluR6 and KA2, two members of the kainate receptor family, determined with subunit-specific antibodies.

GRIK2 GRIK4

1.94e-0554928288598
Pubmed

Kainate receptors: pharmacology, function and therapeutic potential.

GRIK2 GRIK4

1.94e-05549218793656
Pubmed

Complete Disruption of the Kainate Receptor Gene Family Results in Corticostriatal Dysfunction in Mice.

GRIK2 GRIK4

1.94e-05549228228252
Pubmed

Kainate receptor subunits underlying presynaptic regulation of transmitter release in the dorsal horn.

GRIK2 GRIK4

1.94e-05549212223554
Pubmed

Transsynaptic Modulation of Kainate Receptor Functions by C1q-like Proteins.

GRIK2 GRIK4

1.94e-05549227133466
Pubmed

CD2AP in mouse and human podocytes controls a proteolytic program that regulates cytoskeletal structure and cellular survival.

DDN CTSL

1.94e-05549221911934
Pubmed

Molecular determinants of kainate receptor trafficking.

GRIK2 GRIK4

1.94e-05549218358623
Pubmed

Development of laminar distributions of kainate receptors in the somatosensory cortex of mice.

GRIK2 GRIK4

1.94e-0554929593973
Pubmed

Preferential assembly of heteromeric kainate and AMPA receptor amino terminal domains.

GRIK2 GRIK4

1.94e-05549229058671
Pubmed

Peering through the pore: nuclear pore complex structure, assembly, and function.

RGPD4 RGPD8 RGPD3

2.14e-053849312791264
Pubmed

Altered activity, social behavior, and spatial memory in mice lacking the NTAN1p amidase and the asparagine branch of the N-end rule pathway.

UBR2 UBR3

2.91e-05649210805755
Pubmed

N-glycan content modulates kainate receptor functional properties.

GRIK2 GRIK4

2.91e-05649228714086
Pubmed

Neto1 is an auxiliary subunit of native synaptic kainate receptors.

GRIK2 GRIK4

2.91e-05649221734292
Pubmed

Alternative ubiquitin activation/conjugation cascades interact with N-end rule ubiquitin ligases to control degradation of RGS proteins.

UBR2 UBR3

4.07e-05749221816346
Pubmed

Short-term plasticity of kainate receptor-mediated EPSCs induced by NMDA receptors at hippocampal mossy fiber synapses.

GRIK2 GRIK4

4.07e-05749217428973
Pubmed

Glutamate binding and conformational flexibility of ligand-binding domains are critical early determinants of efficient kainate receptor biogenesis.

GRIK2 GRIK4

4.07e-05749219342380
Pubmed

C9orf72 protein quality control by UBR5-mediated heterotypic ubiquitin chains.

RGPD4 METTL13 AGO2 RGPD8 COPE RGPD3 SPART STT3A RGPD5

5.70e-05125749937317656
Pubmed

Splicing and editing of ionotropic glutamate receptors: a comprehensive analysis based on human RNA-Seq data.

GRIK2 GRIK4

6.96e-05949234100982
Pubmed

Expression of glutamate receptor subunit genes during development of the mouse retina.

GRIK2 GRIK4

6.96e-0594929051806
Pubmed

Human immunodeficiency virus type 1 Vpr links proteasomal degradation and checkpoint activation.

UBR2 UBR3

6.96e-05949217855541
Pubmed

Do Gametes Woo? Evidence for Their Nonrandom Union at Fertilization.

AGO2 APOBEC1

1.06e-041149228978771
Pubmed

HIV-1 Vpr function is mediated by interaction with the damage-specific DNA-binding protein DDB1.

UBR2 UBR3

1.27e-041249217360488
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

RGPD4 RGPD8 ZBED4 SYNE1 RGPD3 SAFB2 PABPC5 CAPN11 RGPD5

1.62e-04144249935575683
Pubmed

DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration.

CCR2 AGO2

1.75e-041449221297615
Pubmed

Tlx1/3 and Ptf1a control the expression of distinct sets of transmitter and peptide receptor genes in the developing dorsal spinal cord.

GRIK2 GRIK4 GRM4

2.08e-048149322723691
Pubmed

Proximity labeling of endogenous RICTOR identifies mTOR complex 2 regulation by ADP ribosylation factor ARF1.

RGPD4 RGPD8 RGPD3 RGPD5

2.42e-0421549435973513
Pubmed

The ubiquitin ligase Uhrf2 is a master regulator of cholesterol biosynthesis and is essential for liver regeneration.

RGPD4 RGPD8 RGPD3

2.48e-048649337253089
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

UBR2 FRAS1 ZBED4 SYNE1 DDN

2.67e-0440749512693553
Pubmed

Comprehensive identification of phosphorylation sites in postsynaptic density preparations.

RGPD4 RGPD8 RGPD3 SAFB2

3.18e-0423149416452087
Pubmed

Insights into specificity, redundancy and new cellular functions of C/EBPa and C/EBPb transcription factors through interactome network analysis.

RGPD4 RGPD8 RGPD3

3.75e-049949327746211
Pubmed

Long-term potentiation modulates synaptic phosphorylation networks and reshapes the structure of the postsynaptic interactome.

SYNE1 DDN GRIK2 ITIH4

4.35e-0425149427507650
Pubmed

Cytosolic quality control of mislocalized proteins requires RNF126 recruitment to Bag6.

UBR2 UBR3

4.41e-042249224981174
Pubmed

Genome-wide association study identifies five new schizophrenia loci.

ITIH4 STT3A

4.83e-042349221926974
Pubmed

HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.

AGO2 SYNE1 SAFB2 TMCO3 ITIH4 STT3A

6.44e-0475449635906200
Pubmed

The imprinted Igf2-Igf2r axis is critical for matching placental microvasculature expansion to fetal growth.

ANGPT1 APOBEC1

7.18e-042849234963058
Pubmed

Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.

PLCD4 GRIK2 GRIK4 GRM4

8.47e-0430049419086053
Pubmed

Interaction of Sox2 with RNA binding proteins in mouse embryonic stem cells.

RGPD4 RGPD8 RGPD3

9.25e-0413549331077711
Pubmed

Large-scale analysis of the human ubiquitin-related proteome.

UBR2 AGO2 COPE SPART

9.91e-0431349416196087
Pubmed

KCMF1 (potassium channel modulatory factor 1) Links RAD6 to UBR4 (ubiquitin N-recognin domain-containing E3 ligase 4) and lysosome-mediated degradation.

UBR2 UBR3

9.98e-043349225582440
Pubmed

Systematic analysis of human protein complexes identifies chromosome segregation proteins.

RGPD4 RGPD8 SYNE1 COPE RGPD3 TSEN2 RGPD5

1.11e-03115549720360068
Pubmed

A direct physical interaction between Nanog and Sox2 regulates embryonic stem cell self-renewal.

RGPD4 RGPD8 RGPD3

1.16e-0314649323892456
Pubmed

Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression.

AGO2 RGPD8 SYNE1 RGPD3

1.23e-0333249425693804
Pubmed

Loss of Rearranged L-Myc Fusion (RLF) results in defects in heart development in the mouse.

TEX11 CTSL

1.32e-033849227930960
Pubmed

Systematic identification of factors for provirus silencing in embryonic stem cells.

RGPD4 RGPD8 RGPD3

1.33e-0315349326365490
Pubmed

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.

UBR2 FRAS1 COPE GRIK2 TMCO3 CTSL STT3A

1.39e-03120149735696571
InteractionRGPD4 interactions

RGPD4 RGPD8 RGPD3 RGPD5

2.01e-0722484int:RGPD4
InteractionRGPD2 interactions

RGPD4 RGPD8 RGPD3 RGPD5

4.77e-0727484int:RGPD2
InteractionRGPD3 interactions

RGPD4 RGPD8 RGPD3 RGPD5

4.69e-0647484int:RGPD3
InteractionRGPD1 interactions

RGPD4 RGPD8 RGPD3 RGPD5

5.55e-0649484int:RGPD1
InteractionAKIRIN2 interactions

RGPD8 RGPD3 PSMB9 RGPD5

2.88e-0574484int:AKIRIN2
InteractionRGPD8 interactions

RGPD4 RGPD8 RGPD3 RGPD5

2.88e-0574484int:RGPD8
InteractionTAS2R10 interactions

TAS2R10 RTP4

5.53e-055482int:TAS2R10
InteractionRGPD5 interactions

RGPD4 RGPD8 RGPD3 RGPD5

8.01e-0596484int:RGPD5
Cytoband2q13

RGPD8 RGPD3 RGPD5

5.45e-05684932q13
Cytoband11q13.2

ANKRD13D GPR152

1.17e-034749211q13.2
CytobandEnsembl 112 genes in cytogenetic band chr6p21

UBR2 PSMB9 GRM4 CAPN11

2.04e-03503494chr6p21
Cytoband11q23.3

HMBS STT3A

3.18e-037849211q23.3
CytobandEnsembl 112 genes in cytogenetic band chr2q12

RGPD4 RGPD3

3.51e-0382492chr2q12
GeneFamilyTetratricopeptide repeat domain containing|Bardet-Biedl syndrome associated|BBSome

RGPD4 RGPD8 RGPD3 TANC1 RGPD5

1.96e-06115335769
GeneFamilyGlutamate ionotropic receptor kainate type subunits

GRIK2 GRIK4

3.22e-0553321199
GeneFamilyUbiquitin protein ligase E3 component n-recognins

UBR2 UBR3

6.75e-057332785
GeneFamilyAnkyrin repeat domain containing

ANKRD13D TANC1 POTEA

9.61e-03242333403
Diseaseprostate carcinoma (is_marker_for)

ANGPT1 HMBS

5.39e-0423442DOID:10286 (is_marker_for)
Diseasenighttime rest measurement

LYZL4 TANC1

5.87e-0424442EFO_0007827
DiseaseBipolar Disorder

SYNE1 GRIK2 GRIK4 GRM4 ITIH4

6.98e-04477445C0005586
Diseaseplatelet component distribution width

METTL13 ANGPT1 SYNE1 PSMB9 NHLRC2 TEX11

8.48e-04755446EFO_0007984
Diseaseamyotrophic lateral sclerosis (is_marker_for)

CCR2 ITIH4

8.60e-0429442DOID:332 (is_marker_for)
DiseaseGlobal developmental delay

SPART STT3A PNPO

1.04e-03133443C0557874
Diseaseretinal detachment, retinal break

FRAS1 SMYD1

1.25e-0335442EFO_0005773, EFO_0010698
Diseaseneurodegenerative disease (implicated_via_orthology)

UBR2 UBR3 GRIK2

1.33e-03145443DOID:1289 (implicated_via_orthology)
DiseaseDevelopmental delay (disorder)

SPART STT3A

1.40e-0337442C0424605
Diseaseoral microbiome measurement

FRAS1 GRIK2

1.80e-0342442EFO_0801229

Protein segments in the cluster

PeptideGeneStartEntry
RHNANVGKENRQGWA

ANKRD13D

61

Q6ZTN6
VARLFWHMDQQNRQG

APOBEC1

116

P41238
AARRANQTGHFFWMG

GRM4

296

Q14833
GQAACHMAQGRWEAA

COPE

221

O14579
HMAQGRWEAAEGLLQ

COPE

226

O14579
NMDVNGGGWTVIQHR

ANGPT1

316

Q15389
RAFWMENNGHIAGEQ

CCDC70

196

Q6NSX1
VALMQKNWRHARQQG

CAPN11

446

Q9UMQ6
SRQPMDFQASHWARG

DDN

51

O94850
VQGVWDMRNKQFHTG

AGO2

431

Q9UKV8
GWNRQAGAAGSRMNF

ITIH4

646

Q14624
MGQHGNNVQWRALSE

RGPD5

301

Q99666
MGQHGNNVQWRALSE

RGPD8

301

O14715
GNHWSGARIGKNNMA

FRAS1

3011

Q86XX4
TMAGTQQLADWRNTH

HIPK2

741

Q9H2X6
MRESQDAAGAHGWNR

LEXM

1

Q3ZCV2
FQMRGSDWCGDHGRN

LYZL4

76

Q96KX0
ANGLMAWLAGSQARH

GPR152

46

Q8TDT2
MEFWQGQTNRLHDRI

PNPO

216

Q9NVS9
FWSRNGHDGSMDVQQ

NPIPB7

91

O75200
GHDGSMDVQQRAWRS

NPIPB7

96

O75200
AHLMVAGWDQREGGQ

PSMB9

116

P28065
QRGDILWIAMAGTHQ

NHLRC2

351

Q8NBF2
AAANRAIWHMNGVRL

PABPC5

156

Q96DU9
MGQHGNNVQWRALSE

RGPD3

301

A6NKT7
RGWNNFHTIMRNILG

CCR2

196

P41597
AGLQRMGWHNRVGQI

HMBS

191

P08397
REGWMVRVHQVANSQ

METTL13

176

Q8N6R0
QDDANGQWNGMVREL

GRIK2

491

Q13002
FRQIGQWHVAEGLSM

GRIK4

386

Q16099
FWSRNGHDGSMDVQQ

NPIPB9

106

F8W1W9
GHDGSMDVQQRAWRS

NPIPB9

111

F8W1W9
QIRHMLFSWAERQAG

PIDD1

831

Q9HB75
RGSGKNNMGAWRDHD

POTEA

36

Q6S8J7
EHWTSQGQVRMRLFG

RTP4

76

Q96DX8
WRHNRQMQSNVTGLR

TAS2R10

201

Q9NYW0
HSVEWAAELMRRQGQ

TSEN2

106

Q8NCE0
MGQHGNNVQWRALSE

RGPD4

301

Q7Z3J3
QNDGMTVWHARQARG

PLCD4

41

Q9BRC7
HRGRGVAAMQSRQWV

TMCO3

36

Q6UWJ1
ELGQTWANLDHMVGQ

SYNE1

7106

Q8NF91
LSGWAMRNTNNHNGH

GCM2

61

O75603
VMRAGLTNWHAGNIE

SMYD1

396

Q8NB12
TWNNTHISRVGQAMA

STT3A

546

P46977
HIQGEQGWEDFQQRM

TANC1

781

Q9C0D5
HNRLYGMNEEGWRRA

CTSL

36

P07711
HTGPGWESARQMQQK

SPART

66

Q8N0X7
AHQTGRQLTAESMNW

TEX11

401

Q8IYF3
EHQARAWQGAMDAGA

SAFB2

856

Q14151
VDSRHPQGQWRQDSM

TJP3

871

O95049
HSNMWVRNGLQIKGQ

UBR3

681

Q6ZT12
QVHAGMWRRNGFSLV

UBR2

661

Q8IWV8
MWRAHRAIVLQENGG

ZBED4

331

O75132