Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
HumanPhenoFatal liver failure in infancy

NPC1 COG4

1.04e-053102HP:0006583
HumanPhenoCryptophthalmos

FREM2 FREM1

5.18e-056102HP:0001126
MousePhenocryptophthalmos

FREM2 FREM1

6.44e-063212MP:0005242
DomainCalx_beta

FREM2 FREM1

7.20e-059272IPR003644
DomainCalx-beta

FREM2 FREM1

7.20e-059272PF03160
DomainMFS

MFSD6L SLC16A11 SLC16A2

4.97e-04108273PS50850
DomainMFS_dom

MFSD6L SLC16A11 SLC16A2

9.31e-04134273IPR020846
DomainMFS

SLC16A11 SLC16A2

5.51e-0377272IPR011701
DomainMFS_1

SLC16A11 SLC16A2

5.51e-0377272PF07690
Domain-

CD44 FREM1

8.61e-03972723.10.100.10
DomainC-type_lectin-like/link

CD44 FREM1

8.96e-0399272IPR016186
DomainCTDL_fold

CD44 FREM1

1.04e-02107272IPR016187
DomainCadherin

FREM2 FREM1

1.25e-02118272IPR002126
Domain-

TNS2 ARHGAP20 PLEKHB1

1.84e-023912732.30.29.30
Pubmed

A homozygous mutation p.Arg2167Trp in FREM2 causes isolated cryptophthalmos.

FREM2 FREM1

5.80e-07227229688405
Pubmed

The role of FREM2 and FRAS1 in the development of congenital diaphragmatic hernia.

FREM2 FREM1

3.48e-06427229618029
Pubmed

Differential localization profile of Fras1/Frem proteins in epithelial basement membranes of newborn and adult mice.

FREM2 FREM1

3.48e-06427218563433
Pubmed

Deficiency of FRAS1-related extracellular matrix 1 (FREM1) causes congenital diaphragmatic hernia in humans and mice.

FREM2 FREM1

3.48e-06427223221805
Pubmed

Frem1 activity is regulated by Sonic hedgehog signaling in the cranial neural crest mesenchyme during midfacial morphogenesis.

FREM2 FREM1

3.48e-06427236495293
Pubmed

Novel frem1-related mouse phenotypes and evidence of genetic interactions with gata4 and slit3.

FREM2 FREM1

5.80e-06527223536828
Pubmed

Spatiotemporal distribution of Fras1/Frem proteins during mouse embryonic development.

FREM2 FREM1

5.80e-06527217251066
Pubmed

Basement membrane localization of Frem3 is independent of the Fras1/Frem1/Frem2 protein complex within the sublamina densa.

FREM2 FREM1

5.80e-06527217596926
Pubmed

Mild recessive mutations in six Fraser syndrome-related genes cause isolated congenital anomalies of the kidney and urinary tract.

FREM2 FREM1

8.69e-06627224700879
Pubmed

Frem3, a member of the 12 CSPG repeats-containing extracellular matrix protein family, is a basement membrane protein with tissue distribution patterns distinct from those of Fras1, Frem2, and QBRICK/Frem1.

FREM2 FREM1

8.69e-06627217462874
Pubmed

Members of the Zyxin family of LIM proteins interact with members of the p130Cas family of signal transducers.

NEDD9 NUP210

2.08e-05927211782456
Pubmed

Cytoplasmic Metadherin (MTDH) provides survival advantage under conditions of stress by acting as RNA-binding protein.

NPC1 TNS2 FLNC NUP210

2.19e-0521427422199357
Pubmed

The extracellular matrix gene Frem1 is essential for the normal adhesion of the embryonic epidermis.

FREM2 FREM1

2.60e-051027215345741
Pubmed

Loss-of-function mutations in FREM2 disrupt eye morphogenesis.

FREM2 ECM2

3.18e-051127230802441
Pubmed

The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond.

SLC16A11 SLC16A2

5.25e-051427212739169
Pubmed

Sprouty1 haploinsufficiency prevents renal agenesis in a model of Fraser syndrome.

FREM2 FREM1

6.06e-051527223064016
Pubmed

Identification of a novel cell-adhesive protein spatiotemporally expressed in the basement membrane of mouse developing hair follicle.

FREM2 FREM1

6.92e-051627215878328
Pubmed

Breakdown of the reciprocal stabilization of QBRICK/Frem1, Fras1, and Frem2 at the basement membrane provokes Fraser syndrome-like defects.

FREM2 FREM1

6.92e-051627216880404
Pubmed

Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

TNS2 IGSF9B MED13L

7.21e-0510427310470851
Pubmed

A direct functional link between the multi-PDZ domain protein GRIP1 and the Fraser syndrome protein Fras1.

FREM2 FREM1

8.81e-051827214730302
Pubmed

PDGFRβ regulates craniofacial development through homodimers and functional heterodimers with PDGFRα.

FREM2 FREM1

1.21e-042127227856617
Pubmed

Basement membrane assembly of the integrin α8β1 ligand nephronectin requires Fraser syndrome-associated proteins.

FREM2 FREM1

2.33e-042927222613833
Pubmed

Candidate genetic analysis of plasma high-density lipoprotein-cholesterol and severity of coronary atherosclerosis.

NPC1 LCAT

4.67e-044127219878569
Pubmed

Chromosomal organization of candidate genes involved in cholesterol gallstone formation: a murine gallstone map.

NPC1 LCAT

6.14e-044727211208732
Cytoband16q22.1

PDPR LCAT COG4

3.75e-0511027316q22.1
CytobandEnsembl 112 genes in cytogenetic band chr16q22

PDPR LCAT COG4

1.70e-04183273chr16q22
Cytoband17p13.1

MFSD6L SLC16A11

2.20e-0311827217p13.1
CoexpressionGSE12484_HEALTHY_VS_PERIDONTITIS_NEUTROPHILS_UP

ADAM33 MFSD6L LCAT TMEM132D

1.21e-05139274M433
CoexpressionGSE8515_IL1_VS_IL6_4H_STIM_MAC_DN

NPC1 IGSF9B LCAT MYO15A

4.47e-05194274M5767
ToppCellE18.5-samps-Epithelial-Alveolar_epithelial-AT2_progenitor|E18.5-samps / Age Group, Lineage, Cell class and subclass

SLC16A11 TMEM174 LCAT PLEKHB1 TMEM132D

1.17e-08125275b5fed0e0295aa8ad323c318b59bf23cde3e758c8
ToppCellfacs-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l32-30|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MFSD6L IGSF9B PLEKHB1 TMEM132D

2.80e-061642743caf4cdaa0164907893fea61e251fd8b5fa926e4
ToppCelldroplet-Lung-18m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l39|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ADAM33 FLNC IGSF9B ECM2

4.71e-06187274218c9b4f28499389c43005d9626af2ac01066027
ToppCelldroplet-Lung-18m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ADAM33 FLNC IGSF9B ECM2

4.71e-06187274c7ac4b328efc2ebb72f71154661914193ff402ca
ToppCelldroplet-Lung-nan-18m-Mesenchymal-Airway_Smooth_Muscle|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAM33 FLNC IGSF9B ECM2

4.81e-0618827461f010c165826b434ca3d27553d4c9e13d2c0c51
ToppCell(2)_Fibroblasts-(20)_Fibro-1|World / Cell class and subclass of bone marrow stroma cells in homeostatis

CD44 ADAM33 FLNC ARHGAP20

4.81e-06188274409a7b69d02e87084ca955e3fe6c77230dee8861
ToppCelldroplet-Lung-nan-18m-Mesenchymal-bronchial_smooth_muscle_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAM33 FLNC IGSF9B ECM2

4.81e-061882747553ef7de3575af4cf34704b405b551c1af8eb83
ToppCell(2)_Fibroblasts-(22)_Fibro-3|World / Cell class and subclass of bone marrow stroma cells in homeostatis

CD44 ADAM33 ECM2 FREM1

5.01e-061902743aed03b87ba2c8d479048c3ceef3ff5e38746c28
ToppCellPCW_07-8.5-Epithelial-Epithelial_neuroendo|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

FREM2 SLC16A11 PLEKHB1 TMEM132D

5.44e-06194274b30379f8dc41c86c746af9930541fbb4819d8fa0
ToppCellPCW_05-06-Epithelial|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

FREM2 PLEKHB1 TMEM132D NUP210

5.44e-0619427447a1369c22fcbfe00b08376eb610a61c355548db
ToppCellEnterocyte-C_02|Enterocyte / shred on cell type and cluster

CD44 FREM1 NUP210

7.49e-05136273daf11618c65e8fa2d77001b5c277d534cc012a4b
ToppCellCerebellum-Macroglia-ASTROCYTE|Cerebellum / BrainAtlas - Mouse McCarroll V32

CD44 LCAT FREM1

1.02e-0415127371841d2001200d1595c85c2b007ee20791a72927
ToppCellCerebellum-Macroglia-ASTROCYTE-Gja1|Cerebellum / BrainAtlas - Mouse McCarroll V32

CD44 LCAT FREM1

1.02e-0415127360aced0c1cc6b509b73308d03d58a3c44d712ef4
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_1|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

NEDD9 MFSD6L TMEM132D

1.17e-041582731cefb82b9bf79c687a119be568cfc15b14c6e040
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

FREM2 DESI2 TMEM132D

1.19e-04159273e6ff9d2bce62bf9ea173af80b688eeb40fa4ea4c
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ADAM33 ARHGAP20 ECM2

1.24e-04161273a006491c991e6a134be20ad75092a91f3b7c3c91
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ADAM33 ARHGAP20 ECM2

1.24e-041612734f25eeabb841b0b9204cdd4e71d5e131e7868184
ToppCell5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TNS2 ADAM33 ARHGAP20

1.43e-04169273c0824a93674e2bff0f09b2d2fab5bab016a2e379
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CD44 ADAM33 ARHGAP20

1.48e-041712735d31fc9b60329d4ae3c77e4ca679359d9314397d
ToppCellControl-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_3|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FREM2 ECM2 FREM1

1.48e-041712734ede831aed364cb5271f49a8b09bb6d0452f9b35
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_PAX6-Inh_L1-3_PAX6_NABP1|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ADAM33 FREM2 FREM1

1.53e-041732730d38206e25434386b1aec2078067efc67b496c10
ToppCellTCGA-Breast-Solid_Tissue_Normal-Breast_normal_tissue-Breast_normal_tissue|TCGA-Breast / Sample_Type by Project: Shred V9

ADAM33 ARHGAP20 FREM1

1.55e-041742730f3ec0d0d4344e10c9b48adc9174123f6402dc51
ToppCellTCGA-Breast-Solid_Tissue_Normal-Breast_normal_tissue-Breast_normal_tissue-3|TCGA-Breast / Sample_Type by Project: Shred V9

ADAM33 ARHGAP20 FREM1

1.55e-041742737f8f5fafae08676d2b90cab9802c3c9320f1370e
ToppCellTCGA-Breast-Solid_Tissue_Normal|TCGA-Breast / Sample_Type by Project: Shred V9

ADAM33 ARHGAP20 FREM1

1.55e-04174273e2f240d60bffbe8e6d60f0bb405b231bd3c96875
ToppCellTCGA-Breast-Solid_Tissue_Normal-Breast_normal_tissue|TCGA-Breast / Sample_Type by Project: Shred V9

ADAM33 ARHGAP20 FREM1

1.55e-041742731aadbf2642b6d1320ceabd92e6ff59e11f16c315
ToppCell10x3'2.3-week_17-19-Neuro-stroma-schwann_cells|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

FREM2 IGSF9B PLEKHB1

1.58e-041752738b010220cdfb680ec839572f4933adfb85045ea6
ToppCell3'-GW_trimst-1-SmallIntestine-Mesenchymal-mesothelial_cell-Mesothelium_(RGS5+)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ADAM33 FREM2 MYO15A

1.58e-04175273f5451c29c487b998778e50349b3d774d5e20fd28
ToppCell10x3'2.3-week_17-19-Neuro-stroma|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

FREM2 IGSF9B PLEKHB1

1.58e-041752730b579aeadcc06be83627391c0b01bd8605fdbdf3
ToppCell10x3'2.3-week_17-19-Neuro|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

FREM2 IGSF9B PLEKHB1

1.58e-04175273bbce8b1a160b414c0bf643c21c4e5e78fbccb7e1
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ADAM33 ARHGAP20 ECM2

1.63e-041772739ec7f1e64312d26d434b3312b58386715dbad644
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ADAM33 ARHGAP20 ECM2

1.63e-04177273016277dfd59b1793fddaaadc2b3f41622d76ce3a
ToppCell356C-Fibroblasts-Fibroblast-E-|356C / Donor, Lineage, Cell class and subclass (all cells)

ADAM33 ARHGAP20 ECM2

1.66e-04178273a493a277d175e5e153410a745b26ebe2e0839ea0
ToppCell10x5'v1-week_17-19-Hematopoietic-HSC/MPP_and_pro-MEP|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

ARHGAP20 PLEKHB1 FREM1

1.66e-04178273b8c301d65c0f37941e8e9414d55e90edb6ecc195
ToppCell356C-Fibroblasts-Fibroblast-E|356C / Donor, Lineage, Cell class and subclass (all cells)

ADAM33 ARHGAP20 ECM2

1.66e-04178273371218babddfd3d8a7bb82a46ce65327ee3fcf12
ToppCellControl-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ARHGAP20 ECM2 FREM1

1.72e-0418027308ae0f5d95c45feba68ad99788f7af7ff4c979af
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ADAM33 ARHGAP20 ECM2

1.72e-04180273c2746092ef251e9d5910fe96461afdd0624a24c6
ToppCellControl-Stromal_mesenchymal-Matrix_Fibroblast|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ARHGAP20 ECM2 FREM1

1.72e-041802739b1de1b4711adbf9a423f4d2d08f3f4c78f1f8f4
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ADAM33 ARHGAP20 ECM2

1.72e-0418027332c6a3886428d82fb4355d987c6d2645f333447b
ToppCellControl-Stromal_mesenchymal-Matrix_Fibroblast-Diff_MatrixFB|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ARHGAP20 ECM2 FREM1

1.74e-041812739e7d0f1afb8d9bc5a209ddb5314df3a25a0274d9
ToppCellPericytes-Cryobiopsy_01|World / lung cells shred on cell class, cell subclass, sample id

ADAM33 FLNC ECM2

1.77e-0418227346c213597445b1f4f09dc367f27702d24b201daf
ToppCellPCW_05-06-Epithelial-Epithelial_neuroendo-epi_neuroendocrine2[NE2]_(12)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

MFSD6L SLC16A11 TMEM132D

1.77e-04182273dc29e8735c3562ce32322351d28f7d9709208ebf
ToppCellfacs-Heart-RA|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD44 SLC16A2 ECM2

1.77e-041822738292e8e8474c930ffb88cbab4f6ebdb6f58db645
ToppCellPCW_05-06-Epithelial-Epithelial_airway-epi_proximal_progenitor1_(6)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

FREM2 PLEKHB1 TMEM132D

1.80e-04183273c5b10571599dc26476170b54b53f09c23e6b3117
ToppCellE15.5-Mesenchymal-mesenchymal_fibroblast-mesothelial_cell_of_visceral_pleura|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

ADAM33 FREM2 FLNC

1.80e-04183273274f274cf60daa30d6a4cd603a3af7823bfb8016
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FREM2 MYO15A FREM1

1.83e-04184273ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellCerebellum-Macroglia|Cerebellum / BrainAtlas - Mouse McCarroll V32

LCAT PLEKHB1 FREM1

1.83e-0418427391b047a01d2cad231308279ca37fa699630f7864
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FREM2 MYO15A FREM1

1.83e-041842732cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FREM2 MYO15A FREM1

1.83e-041842732b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

NEDD9 DESI2 TMEM132D

1.83e-0418427329c95b814a0b1ad8734ed68b77df29c08594e5ec
ToppCellE17.5-Mesenchymal-mesenchymal_fibroblast-mesothelial_cell_of_visceral_pleura|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

ADAM33 FREM2 FLNC

1.83e-04184273607b55022de21ddb6a2d75e085df76df7abf6624
ToppCellTCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-4|TCGA-Pancreas / Sample_Type by Project: Shred V9

MED13L ECM2 FREM1

1.83e-0418427367164bb6bcae7322cb89b585c7aa10bce35b0ecd
ToppCellfacs-Skin-nan-24m-Mesenchymal|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAM33 ARHGAP20 ECM2

1.86e-041852738433a337625ff8398520e223ef92bf9bb0beb14c
ToppCelldroplet-Limb_Muscle-Pre-Sort-18m-Macroglial-unknown|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FREM2 IGSF9B PLEKHB1

1.86e-0418527311c147f3f5570c4761d2bcff3bad28146b4a5861
ToppCellfacs-Skin-nan-24m-Mesenchymal-fibroblast|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAM33 ARHGAP20 ECM2

1.86e-04185273049d793d043d5d434f143025de49dd210d18756c
ToppCellControl-Epithelial-Mesothelial|Epithelial / Disease state, Lineage and Cell class

ADAM33 FLNC ECM2

1.86e-041852730af540323c0113203ba6c1a4cb32d2fb9cf79d39
ToppCellfacs-Skin-nan-24m-Mesenchymal-nan|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAM33 ARHGAP20 ECM2

1.86e-0418527363200c42565eea596f9b00728e70e544b8d50a7f
ToppCellPCW_07-8.5-Epithelial-Epithelial_neuroendo-epi_neuroendocrine2[NE2]_(12)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

SLC16A11 PLEKHB1 TMEM132D

1.89e-04186273c7983281a290201567b398e9ea6baddb96c692bb
ToppCellwk_08-11-Epithelial-Proximal_epithelial-Pulmonary_NE_precursor|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

SLC16A11 PLEKHB1 NUP210

1.89e-04186273dfd67d67c103c942de6c8acef8d81e57a9886154
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

NEDD9 FREM2 TMEM132D

1.89e-041862735c4ffe4e4d5536ae9f8794277fe032c693e7dd56
ToppCellCOPD-Epithelial-ATII|Epithelial / Disease state, Lineage and Cell class

NPC1 CD44 FREM2

1.92e-04187273030af361f8bdcd0aff4ec1922702833325cf74d8
ToppCelldroplet-Limb_Muscle-Pre-Sort-18m-Macroglial-Schwann_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FREM2 IGSF9B PLEKHB1

1.95e-041882733b8b9161f0fdcbde302ce5b4c0bc874628211109
ToppCelldroplet-Limb_Muscle-Pre-Sort-18m-Macroglial|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FREM2 IGSF9B PLEKHB1

1.95e-04188273c2101ded71fb16b8ddbc1f883911b1ed2a533ffc
ToppCellPCW_10-12-Epithelial-Epithelial_neuroendo-epi_NE_progenitor_(7)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

FREM2 SLC16A11 TMEM132D

1.95e-041882733cfba3addcc9058f4ec31ad96261f79988f551a0
ToppCellhuman_hepatoblastoma-Tumor_cells-T5|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

CD44 FREM2 FREM1

1.95e-04188273b070a0667f1ee9b825b267b6c389b7c42fc436f9
ToppCellFetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ARHGAP20 ECM2 FREM1

1.98e-04189273203c80030df08ae112f9ae4043709f455d87ce89
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

NPC1 CD44 NEDD9

1.98e-041892738c8ca3b30d9be6c854615459a7bfba82b427c8bc
ToppCellfacs-Skin-nan-18m-Mesenchymal-nan|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAM33 ARHGAP20 ECM2

1.98e-0418927329287525120be2953b76881ba3cfc4379c265e7a
ToppCellfacs-Skin-nan-18m-Mesenchymal-fibroblast|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAM33 ARHGAP20 ECM2

1.98e-041892737150dad9a92a715487c2d8130fa01b752ea69663
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

NPC1 CD44 NEDD9

1.98e-041892735d902a4660a27548764bf04c6de152b565da835c
ToppCellfacs-Skin-nan-18m-Mesenchymal|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAM33 ARHGAP20 ECM2

1.98e-041892736e4c0effd5192fd00052abc048fdb87a74fb6554
ToppCell10x5'v1-week_12-13-Mesenchymal_fibro-stroma-endosteal_fibroblast|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

ADAM33 FLNC SLC16A2

1.98e-04189273473b01c9162b12b90a617c600238436177a0d18d
ToppCell(4)_Endothelial_cells-(40)_EC-arterial|(4)_Endothelial_cells / Cell class and subclass of bone marrow stroma cells in homeostatis

CD44 FLNC ECM2

2.01e-04190273ff774faf3f12759d11e50ed7d189288bb79e22e1
ToppCellPCW_07-8.5-Epithelial-Epithelial_airway-epi_intermediate_(1)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

FREM2 TMEM132D NUP210

2.01e-04190273c95032bb3ee2b3d40fdf48016acb46d6f78a48a6
ToppCell10x5'v1-week_14-16-Mesenchymal_fibro-stroma-endosteal_fibroblast|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

FLNC IGSF9B ECM2

2.04e-0419127344b1f62fdee03b157fe545f2ae6ff84f8929a8ac
ToppCellControl-Stromal_mesenchymal|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ADAM33 ARHGAP20 FREM1

2.04e-0419127314057205ddb9b4bbc582d1358d13cf36d979a61b
ToppCellPCW_13-14-Epithelial-Epithelial_neuroendo-epi_neuroendocrine2[NE2]_(12)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

PLEKHB1 TMEM132D NUP210

2.04e-0419127319832ddd559a353e1618fe853d79e3edfec6dcda
ToppCell10x5'v1-week_12-13-Mesenchymal_fibro-stroma|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

ADAM33 FLNC SLC16A2

2.08e-041922734ed5040594ba2d0639f0990697504ecef872ca70
ToppCelldroplet-Lung-18m-Mesenchymal-myofibroblast|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ADAM33 FLNC ECM2

2.08e-041922732cc712186e37fb21a964c032765c36a8b4a852cf
ToppCellPCW_07-8.5-Epithelial-Epithelial_alveolar-distal|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

FREM2 PLEKHB1 NUP210

2.08e-04192273b7c01e12b3e9be960a741b08835f1dfff65d0d47
ToppCell10x5'v1-week_12-13-Mesenchymal_fibro|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

ADAM33 FLNC SLC16A2

2.08e-04192273d4f5d6653564c2c5d0f5f7c932d89cb1b1412844
ToppCellPericytes|World / lung cells shred on cell class, cell subclass, sample id

ADAM33 FLNC ECM2

2.08e-04192273057ad22b878c0c5fb59ed1412ca13db945c57a5a
ToppCellPCW_05-06-Epithelial-Epithelial_proliferating|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

FREM2 PLEKHB1 NUP210

2.11e-041932735f0eba7b1440beb891d94a288f7f18a4e13c3a88
ToppCellPCW_07-8.5-Epithelial-Epithelial_alveolar-distal-epi_CTGF^high_distal_(3)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

FREM2 PLEKHB1 NUP210

2.11e-04193273ab78fb1603ea6f720ba2d30148fe65dccf271fe1
ToppCell3'-GW_trimst-1.5-SmallIntestine-Mesenchymal-myocytic|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CD44 FREM2 FLNC

2.11e-04193273b1893193766ae41bf2ab6ed4083285c9c814e608
ToppCellParenchymal-NucSeq-Stromal-Fibroblastic-Fibro_perichondrial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ADAM33 FLNC FREM1

2.11e-04193273e5016959f24370579a8770787e96869f264cf7b3
ToppCell10x5'v1-week_12-13-Mesenchymal_fibro-stroma-arteriolar_fibroblast|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

ADAM33 FLNC IGSF9B

2.11e-041932733d85c28f6ebdcb15e875ad01d52d6c138fbf8525
ToppCellP28-Mesenchymal-myocytic_cell-aortic_smooth_muscle_cell|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

CD44 ADAM33 ECM2

2.14e-041942733c661c6768c3f05d2aba03d329adb257ca201b2d
ToppCellPCW_07-8.5-Epithelial|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

FREM2 TMEM132D NUP210

2.14e-04194273f63ceedb88a9abc8644ee94adfd541e7817c1e3a
ToppCellwk_08-11-Epithelial-Proximal_epithelial-Pulmonary_neuroendocrine|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

SLC16A11 PLEKHB1 NUP210

2.14e-04194273ccff0b5814f5de2d42720018e7f5dc5dcdafb568
ToppCellP15-Mesenchymal-myocytic_cell-aortic_smooth_muscle_cell|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

CD44 ADAM33 ECM2

2.14e-041942735f04d21c4e2d36e74b6c5889aa97fd98f75a0973
ToppCellPCW_05-06-Epithelial-Epithelial_alveolar-distal-epi_SOX9^high_Etv5^medium_distal_(2)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

FREM2 PLEKHB1 NUP210

2.14e-04194273413112ee8df7407fd418d57c2ff11aad3a6ec259
ToppCellPCW_05-06-Epithelial-Epithelial_alveolar-distal|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

FREM2 PLEKHB1 NUP210

2.14e-04194273acd5ba9a097595d4caab4f05440531c65a4aa7bc
ToppCelldroplet-Lung-nan-3m-Mesenchymal-Myofibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAM33 FLNC ECM2

2.17e-04195273d32716a12014522492becbde1088dc1106308490
ToppCelldroplet-Lung-nan-3m-Mesenchymal-pulmonary_interstitial_fibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAM33 FLNC ECM2

2.17e-04195273b913d5df50c88a3a255f516a1aa42419c6701e1e
ToppCellIPF-Stromal-Fibroblast|World / Disease state, Lineage and Cell class

ADAM33 FLNC ECM2

2.17e-041952739c32756edb54f0c211185d9a98073fe01fd1526a
ToppCell-Cryobiopsy_01|World / lung cells shred on cell class, cell subclass, sample id

ADAM33 ECM2 FREM1

2.17e-04195273e5b0afbea85575851cf9eb50a9ac42c67bbf3d7c
ToppCell5'-GW_trimst-1-SmallIntestine-Mesenchymal-mesothelial_cell|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ADAM33 FREM2 MYO15A

2.20e-04196273429de4119c8b2193c992d36a6af84f806730cbee
ToppCell5'-GW_trimst-1-SmallIntestine-Mesenchymal-mesothelial_cell-Mesothelium_(RGS5+)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ADAM33 FREM2 MYO15A

2.20e-041962738c8a73d9d9581b8d9a9babfa93459d12fb9eb3ac
ToppCell3'-Broncho-tracheal-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts-Peribronchial_fibroblasts_L.2.1.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ADAM33 ECM2 FREM1

2.20e-04196273e7bfd4fb400ae0c473131d0fa306c26be08a6d03
ToppCellP15-Mesenchymal-myocytic_cell|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

CD44 ADAM33 ECM2

2.20e-0419627341ae5b0d81ad09a6663335d899b4a1e4976c3b62
Drugprochlorperazine dimaleate salt; Up 200; 10uM; MCF7; HG-U133A

NPC1 CD44 GPATCH8 MED13L MYO15A

2.88e-06193275455_UP
DrugICI 182,780; Down 200; 0.01uM; MCF7; HT_HG-U133A_EA

CD44 MED13L SLC16A2 NUP210

5.75e-051802741076_DN
DrugSB10

CD44 MYO15A

6.06e-0510272CID000046019
Drugquinocarcin

CD44 MYO15A

7.40e-0511272CID000158486
DrugMevalonic-D, L acid lactone [674-26-0]; Down 200; 30.8uM; MCF7; HT_HG-U133A

CD44 NEDD9 TNS2 PLEKHB1

7.85e-051952743459_DN
Drugmonastrol; Up 200; 100uM; MCF7; HG-U133A

CD44 TNS2 GPATCH8 PLEKHB1

7.85e-05195274596_UP
DrugTrimetazidine dihydrochloride [13171-25-0]; Down 200; 11.8uM; MCF7; HT_HG-U133A

CD44 NEDD9 DESI2 NUP210

8.00e-051962742876_DN
DrugErythromycin [114-07-8]; Down 200; 5.4uM; MCF7; HT_HG-U133A

TNS2 GPATCH8 PLEKHB1 COG4

8.32e-051982741510_DN
DrugMolindone hydrochloride [15622-65-8]; Down 200; 12.8uM; MCF7; HT_HG-U133A

CD44 TNS2 PLEKHB1 NUP210

8.49e-051992747337_DN
Drugchlorpromazine hydrochloride; Up 200; 1uM; MCF7; HG-U133A

CD44 NEDD9 MED13L SLC16A2

8.49e-05199274426_UP
DiseaseMarles Greenberg Persaud syndrome

FREM2 FREM1

8.06e-072272C1855425
DiseaseFraser syndrome (implicated_via_orthology)

FREM2 FREM1

4.83e-064272DOID:0090001 (implicated_via_orthology)
DiseaseUnilateral agenesis of kidney

FREM2 FREM1

2.25e-058272C0266294
Diseaselactate measurement

PDPR ARHGAP20

5.85e-0439272EFO_0007745
Diseasecutaneous melanoma, hair color

MED13L ARHGAP20

1.47e-0362272EFO_0000389, EFO_0003924

Protein segments in the cluster

PeptideGeneStartEntry
TPVRTGHGYVYEYPS

NEDD9

156

Q14511
HQPIVETYYGPGRLY

COG4

286

Q9H9E3
GYIETHYGPDGQPVV

ADAM33

91

Q9BZ11
AYGGHPYPFSGIFEI

DESI2

41

Q9BSY9
YHVAFYFAGVPPIIG

SLC16A2

476

P36021
YVVEPGYLGFTVHPG

NUP210

341

Q8TEM1
TALVGGGYFVPYVHL

SLC16A11

251

Q8NCK7
PYGGHRDVAYIVVCP

MED13L

1411

Q71F56
VGVYAGREHFVYGEP

MAGEC2

256

Q9UBF1
PYGVHYTVPYAEGVY

MYO15A

371

Q9UKN7
LYVSYVFHSPVGVGG

FREM2

2676

Q5SZK8
SGPRGVVHFYGYSVV

MFSD6L

316

Q8IWD5
AGATEPEYYHYIPPA

GPATCH8

386

Q9UKJ3
HTGEPGFMLYIPIEY

PDPR

671

Q8NCN5
YGGDEIPYSPFRIHA

FLNC

1616

Q14315
PPRYGQIEYVHYPGV

FREM1

1436

Q5H8C1
GPPVYFVLEEGHDYT

NPC1

886

O15118
GGYIFYTFSTVHPIP

CD44

191

P16070
IPGYVFGHMEPGLEY

ECM2

571

O94769
YDHGFPYTDPVGVLY

LCAT

351

P04180
EEAPYPLIGHEYPYG

ARHGAP20

251

Q9P2F6
GTPVELYYTVHPGGE

TMEM132D

221

Q14C87
HGVSYVVPIYEGYPL

ACTL7A

221

Q9Y615
GYYPPHVDPEYAGRA

IGSF9B

76

Q9UPX0
SYYGPPYAGPGVTHV

PLEKHB1

191

Q9UF11
YTYRGSISGHPYLPE

SMRP1

71

Q8NCR6
FHGATVVQYIPPPYG

TMEM174

131

Q8WUU8
GRYGHPGYPALVTYS

TNS2

776

Q63HR2