Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	dendritic spine development	SHANK1 DLG5 RELN CDK5R1 ARID1B MTOR NLGN2	2.22e-06	141	87	7	GO:0060996
GeneOntologyBiologicalProcess	neuromuscular process	SHANK1 MTOR ATP8A2 KBTBD13 NLGN2 TNR ATP2B2 CHRNG	4.93e-06	225	87	8	GO:0050905
GeneOntologyBiologicalProcess	positive regulation of dendritic spine development	SHANK1 DLG5 RELN MTOR NLGN2	1.16e-05	70	87	5	GO:0060999
GeneOntologyBiologicalProcess	synaptic signaling	SHANK1 SLC6A9 RELN CDK5R1 ARID1B TRIO TSPOAP1 MTOR ACHE GRIA1 NLGN2 ACE TNR ATP2B2 CHRNG	1.29e-05	976	87	15	GO:0099536
GeneOntologyBiologicalProcess	modulation of chemical synaptic transmission	SHANK1 SLC6A9 RELN TRIO TSPOAP1 MTOR ACHE GRIA1 NLGN2 ACE TNR ATP2B2	2.16e-05	663	87	12	GO:0050804
GeneOntologyBiologicalProcess	regulation of trans-synaptic signaling	SHANK1 SLC6A9 RELN TRIO TSPOAP1 MTOR ACHE GRIA1 NLGN2 ACE TNR ATP2B2	2.19e-05	664	87	12	GO:0099177
GeneOntologyBiologicalProcess	anterograde trans-synaptic signaling	SHANK1 SLC6A9 RELN ARID1B TRIO TSPOAP1 MTOR ACHE GRIA1 NLGN2 ACE TNR ATP2B2 CHRNG	3.31e-05	931	87	14	GO:0098916
GeneOntologyBiologicalProcess	chemical synaptic transmission	SHANK1 SLC6A9 RELN ARID1B TRIO TSPOAP1 MTOR ACHE GRIA1 NLGN2 ACE TNR ATP2B2 CHRNG	3.31e-05	931	87	14	GO:0007268
GeneOntologyBiologicalProcess	trans-synaptic signaling	SHANK1 SLC6A9 RELN ARID1B TRIO TSPOAP1 MTOR ACHE GRIA1 NLGN2 ACE TNR ATP2B2 CHRNG	3.63e-05	939	87	14	GO:0099537
GeneOntologyBiologicalProcess	neuron cell-cell adhesion	CDK5R1 NLGN2 TNR	3.90e-05	16	87	3	GO:0007158
GeneOntologyBiologicalProcess	regulation of dendritic spine development	SHANK1 DLG5 RELN MTOR NLGN2	4.16e-05	91	87	5	GO:0060998
GeneOntologyBiologicalProcess	long-term memory	SHANK1 RELN MTOR GRIA1	4.99e-05	48	87	4	GO:0007616
GeneOntologyBiologicalProcess	dendrite development	SHANK1 DLG5 RELN CDK5R1 ARID1B MTOR ACHE NLGN2	8.54e-05	335	87	8	GO:0016358
GeneOntologyBiologicalProcess	regulation of neurotransmitter receptor activity	SHANK1 SLC6A9 RELN NLGN2	9.17e-05	56	87	4	GO:0099601
GeneOntologyBiologicalProcess	regulation of cellular component biogenesis	SHANK1 SPTBN5 USP10 DLG5 THBS2 CDK5R1 MTOR SPTA1 BAK1 DAAM2 RICTOR NLGN2 SIX1 ACE DYNC1H1	1.24e-04	1189	87	15	GO:0044087
GeneOntologyBiologicalProcess	synapse organization	SHANK1 DLG5 RELN THBS2 CDK5R1 ACHE GRIA1 NLGN2 SIX1 TNR ATP2B2	1.41e-04	685	87	11	GO:0050808
GeneOntologyBiologicalProcess	spinal cord development	RELN MTOR GRIA1 DAAM2 SUFU	1.49e-04	119	87	5	GO:0021510
GeneOntologyBiologicalProcess	regulation of AMPA receptor activity	SHANK1 RELN NLGN2	1.56e-04	25	87	3	GO:2000311
GeneOntologyBiologicalProcess	musculoskeletal movement	MTOR ATP8A2 KBTBD13 CHRNG	2.07e-04	69	87	4	GO:0050881
GeneOntologyBiologicalProcess	associative learning	SHANK1 RELN MTOR TNR ABCA7	2.25e-04	130	87	5	GO:0008306
GeneOntologyBiologicalProcess	regulation of signaling receptor activity	SHANK1 SLC6A9 RELN CDK5R1 NLGN2	2.33e-04	131	87	5	GO:0010469
GeneOntologyBiologicalProcess	multicellular organismal movement	MTOR ATP8A2 KBTBD13 CHRNG	2.57e-04	73	87	4	GO:0050879
GeneOntologyBiologicalProcess	'de novo' pyrimidine nucleobase biosynthetic process	CMPK1 MTOR	2.61e-04	6	87	2	GO:0006207
GeneOntologyBiologicalProcess	neuromuscular process controlling balance	SHANK1 NLGN2 TNR ATP2B2	2.71e-04	74	87	4	GO:0050885
GeneOntologyBiologicalProcess	synapse assembly	DLG5 RELN THBS2 ACHE GRIA1 NLGN2 SIX1	3.26e-04	308	87	7	GO:0007416
GeneOntologyBiologicalProcess	regulation of protein polymerization	SPTBN5 CDK5R1 MTOR SPTA1 DAAM2 RICTOR	4.39e-04	231	87	6	GO:0032271
GeneOntologyCellularComponent	excitatory synapse	SHANK1 SLC6A9 GRIA1 NLGN2 ATP2B2	8.94e-05	107	88	5	GO:0060076
GeneOntologyCellularComponent	TORC2 complex	MTOR RICTOR	6.19e-04	9	88	2	GO:0031932
GeneOntologyCellularComponent	spectrin	SPTBN5 SPTA1	6.19e-04	9	88	2	GO:0008091
GeneOntologyCellularComponent	bBAF complex	ARID1B SMARCA4	7.71e-04	10	88	2	GO:0140092
GeneOntologyCellularComponent	photoreceptor connecting cilium	SPTBN5 AHI1 ADGRV1	1.09e-03	48	88	3	GO:0032391
GeneOntologyCellularComponent	TOR complex	MTOR RICTOR	1.13e-03	12	88	2	GO:0038201
GeneOntologyCellularComponent	npBAF complex	ARID1B SMARCA4	1.54e-03	14	88	2	GO:0071564
GeneOntologyCellularComponent	postsynaptic membrane	SHANK1 SLC6A9 ACHE GRIA1 NLGN2 ATP2B2 CHRNG	1.61e-03	405	88	7	GO:0045211
GeneOntologyCellularComponent	neuron to neuron synapse	SHANK1 SLC6A9 DLG5 CDK5R1 GRIA1 NLGN2 TNR ATP2B2	1.62e-03	523	88	8	GO:0098984
GeneOntologyCellularComponent	extracellular matrix	A2M TRIL COL6A2 RELN THBS2 ACHE PLOD1 TNR SCARA3	1.76e-03	656	88	9	GO:0031012
GeneOntologyCellularComponent	collagen-containing extracellular matrix	A2M COL6A2 RELN THBS2 ACHE PLOD1 TNR SCARA3	1.76e-03	530	88	8	GO:0062023
GeneOntologyCellularComponent	external encapsulating structure	A2M TRIL COL6A2 RELN THBS2 ACHE PLOD1 TNR SCARA3	1.79e-03	658	88	9	GO:0030312
MousePheno	abnormal forebrain morphology	SHANK1 GMNC DLG5 RELN CDK5R1 ARID1B CENPA TRIO MTOR ACHE SPTA1 SARDH HSD17B2 SIX1 SUFU TNR ATP2B2 DYNC1H1 THOC6	1.29e-06	1072	72	19	MP:0000783
MousePheno	abnormal telencephalon morphology	SHANK1 GMNC DLG5 RELN CDK5R1 ARID1B TRIO MTOR ACHE SPTA1 SARDH HSD17B2 TNR ATP2B2 DYNC1H1 THOC6	2.78e-06	812	72	16	MP:0000787
MousePheno	abnormal cerebral hemisphere morphology	SHANK1 GMNC RELN CDK5R1 ARID1B TRIO ACHE SPTA1 SARDH HSD17B2 TNR ATP2B2 DYNC1H1	9.96e-06	599	72	13	MP:0008540
MousePheno	abnormal nervous system development	SHANK1 GMNC DLG5 RELN CDK5R1 ARID1B AHI1 CENPA MTOR RTTN SMARCA4 POR MLLT10 HSD17B2 SIX1 SUFU ATP2B2 DYNC1H1 THOC6	1.34e-05	1257	72	19	MP:0003861
MousePheno	abnormal hippocampus pyramidal cell layer	SHANK1 RELN CDK5R1 ARID1B TNR	3.15e-05	71	72	5	MP:0008284
MousePheno	abnormal temporal lobe morphology	SHANK1 GMNC RELN CDK5R1 ARID1B TRIO SARDH TNR ATP2B2	5.53e-05	337	72	9	MP:0000801
MousePheno	small kidney	NELL1 THBS2 ARID1B KCNT2 POR HSD17B2 SIX1 ACE ABCA7 SIX2	6.03e-05	425	72	10	MP:0002989
MousePheno	abnormal cerebellar granule layer morphology	RELN CDK5R1 AHI1 WDR81 ATP2B2	7.50e-05	85	72	5	MP:0000886
MousePheno	slow extinction of fear memory	CDK5R1 ARID1B	7.82e-05	3	72	2	MP:0012318
MousePheno	abnormal hippocampus layer morphology	SHANK1 RELN CDK5R1 ARID1B TNR	1.09e-04	92	72	5	MP:0000813
MousePheno	decreased startle reflex	SHANK1 ARID1B ATP8A2 GRIA1 NLGN2 ADGRV1 ATP2B2	1.50e-04	224	72	7	MP:0001489
MousePheno	lethality during fetal growth through weaning, complete penetrance	GMNC SLC6A9 NELL1 ARID1B AHI1 TRIO ACHE ATP8A2 SPTA1 SCNN1B RICTOR CALCRL SIX1 SUFU SIX2 DYNC1H1 CHRNG	1.90e-04	1269	72	17	MP:0011111
MousePheno	abnormal startle reflex	SHANK1 SEC61A2 ARID1B ATP8A2 SPTA1 WDR81 GRIA1 NLGN2 ADGRV1 SUFU ATP2B2	2.03e-04	591	72	11	MP:0001486
MousePheno	abnormal reflex	SHANK1 SEC61A2 SLC6A9 NELL1 RELN ARID1B ACHE ATP8A2 SPTA1 WDR81 GRIA1 NLGN2 ADGRV1 SIX1 SUFU ATP2B2 DYNC1H1	2.40e-04	1294	72	17	MP:0001961
MousePheno	abnormal posture	SLC6A9 RELN ACHE ATP8A2 ATP2B2 DYNC1H1 CHRNG	2.48e-04	243	72	7	MP:0001504
MousePheno	abnormal hippocampus morphology	SHANK1 GMNC RELN CDK5R1 ARID1B TRIO SARDH TNR	2.91e-04	331	72	8	MP:0000807
MousePheno	abnormal cutaneous collagen fibril morphology	THBS2 PLOD1 DSE	3.51e-04	27	72	3	MP:0008438
MousePheno	decreased kidney weight	ARID1B POR HSD17B2 ACE	3.66e-04	66	72	4	MP:0003918
MousePheno	delaminated Purkinje cell layer	RELN CDK5R1	3.87e-04	6	72	2	MP:0000884
MousePheno	abnormal brain development	GMNC DLG5 RELN CDK5R1 ARID1B AHI1 MTOR HSD17B2 SUFU DYNC1H1 THOC6	3.92e-04	638	72	11	MP:0000913
MousePheno	abnormal sensory capabilities/reflexes/nociception	SHANK1 SEC61A2 SLC6A9 NELL1 RELN CDK5R1 ARID1B ACHE ATP8A2 SPTA1 WDR81 GRIA1 NLGN2 ADGRV1 SIX1 SUFU ATP2B2 DYNC1H1	4.12e-04	1486	72	18	MP:0002067
MousePheno	abnormal telencephalon development	RELN CDK5R1 MTOR DYNC1H1 THOC6	4.74e-04	126	72	5	MP:0000934
MousePheno	embryonic growth retardation	DLG5 CENPA MTOR NOA1 RTTN POR RICTOR HSD17B2 SIX1 SUFU ACE THOC6	4.79e-04	763	72	12	MP:0003984
MousePheno	abnormal neuron number	RELN ARID1B ATP8A2 WDR81 SIX1 ATP2B2 SLC7A14 DYNC1H1 CHRNG	5.31e-04	456	72	9	MP:0008946
Domain	Pecanex_C	PCNX2 PCNX3 PCNX1	4.03e-07	4	88	3	PF05041
Domain	Pecanex	PCNX2 PCNX3 PCNX1	4.03e-07	4	88	3	IPR007735
Domain	Spectrin	SPTBN5 SYNE3 TRIO SPTA1	3.80e-06	23	88	4	PF00435
Domain	Spectrin_repeat	SPTBN5 SYNE3 TRIO SPTA1	9.99e-06	29	88	4	IPR002017
Domain	SPEC	SPTBN5 SYNE3 TRIO SPTA1	1.50e-05	32	88	4	SM00150
Domain	Spectrin/alpha-actinin	SPTBN5 SYNE3 TRIO SPTA1	1.50e-05	32	88	4	IPR018159
Domain	CARBOXYLESTERASE_B_2	ACHE CES3 NLGN2	3.54e-05	14	88	3	PS00941
Domain	COesterase	ACHE CES3 NLGN2	3.54e-05	14	88	3	PF00135
Domain	CarbesteraseB	ACHE CES3 NLGN2	3.54e-05	14	88	3	IPR002018
Domain	ARM-like	ARID1B MTOR XPO6 RTTN DAAM2 RICTOR USP35	2.86e-04	270	88	7	IPR011989
Domain	BRK	SMARCA4 CHD9	3.25e-04	6	88	2	SM00592
Domain	BRK_domain	SMARCA4 CHD9	3.25e-04	6	88	2	IPR006576
Domain	BRK	SMARCA4 CHD9	3.25e-04	6	88	2	PF07533
Domain	SIX1_SD	SIX1 SIX2	4.54e-04	7	88	2	IPR031701
Domain	SIX1_SD	SIX1 SIX2	4.54e-04	7	88	2	PF16878
Domain	SH3	SHANK1 DLG5 AHI1 TRIO TSPOAP1 SPTA1	5.50e-04	216	88	6	SM00326
Domain	SH3	SHANK1 DLG5 AHI1 TRIO TSPOAP1 SPTA1	5.50e-04	216	88	6	PS50002
Domain	Carboxylesterase_B_AS	ACHE CES3	6.03e-04	8	88	2	IPR019826
Domain	CARBOXYLESTERASE_B_1	ACHE CES3	6.03e-04	8	88	2	PS00122
Domain	SH3_domain	SHANK1 DLG5 AHI1 TRIO TSPOAP1 SPTA1	6.05e-04	220	88	6	IPR001452
Domain	-	ARID1B MTOR XPO6 RTTN DAAM2 RICTOR	6.35e-04	222	88	6	1.25.10.10
Domain	-	NELL1 THBS2 SHBG ADGRV1	1.06e-03	95	88	4	2.60.120.200
Domain	ARM-type_fold	PIK3C2B MTOR XPO6 RTTN DAAM2 RICTOR USP35	1.10e-03	339	88	7	IPR016024
Domain	EGF_dom	NELL1 THBS2	1.40e-03	12	88	2	IPR024731
Domain	EGF_3	NELL1 THBS2	1.40e-03	12	88	2	PF12947
Domain	Carboxylesterase_B_CS	ACHE NLGN2	1.66e-03	13	88	2	IPR019819
Domain	PI3/4_kinase_CS	PIK3C2B MTOR	2.21e-03	15	88	2	IPR018936
Domain	-	FASN ACHE CES3 NLGN2	2.42e-03	119	88	4	3.40.50.1820
Domain	AB_hydrolase	FASN ACHE CES3 NLGN2	2.42e-03	119	88	4	IPR029058
Domain	-	PIK3C2B MTOR	2.52e-03	16	88	2	1.10.1070.11
Domain	PI3Kc	PIK3C2B MTOR	2.52e-03	16	88	2	SM00146
Domain	Laminin_G	NELL1 THBS2 SHBG	2.59e-03	58	88	3	IPR001791
Domain	EGF_extracell	NELL1 RELN TNR	2.85e-03	60	88	3	IPR013111
Domain	EGF_2	NELL1 RELN TNR	2.85e-03	60	88	3	PF07974
Domain	PI3_PI4_kinase	PIK3C2B MTOR	3.20e-03	18	88	2	PF00454
Domain	PI3_4_KINASE_1	PIK3C2B MTOR	3.20e-03	18	88	2	PS00915
Domain	PI3_4_KINASE_2	PIK3C2B MTOR	3.20e-03	18	88	2	PS00916
Domain	PI3/4_kinase_cat_dom	PIK3C2B MTOR	3.20e-03	18	88	2	IPR000403
Domain	PI3_4_KINASE_3	PIK3C2B MTOR	3.20e-03	18	88	2	PS50290
Domain	ConA-like_dom	NELL1 THBS2 MALRD1 SHBG ADGRV1	3.77e-03	219	88	5	IPR013320
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	CCDC142 PCNX2 FASN CDK5R1 NADSYN1 SYNE3 PCNX3 TRIO PIK3C2B MTOR XPO6 RTTN SREBF1 PCNX1 NLGN2 SFI1 MLLT10 SUFU ABCA7 SCARA3 DYNC1H1	7.75e-13	1105	91	21	35748872
Pubmed	Hepatic mTORC2 activates glycolysis and lipogenesis through Akt, glucokinase, and SREBP1c.	MTOR SREBF1 RICTOR	1.73e-07	5	91	3	22521878
Pubmed	Lacrimal gland budding requires PI3K-dependent suppression of EGF signaling.	MTOR RICTOR SIX1 SIX2	1.49e-06	32	91	4	34193412
Pubmed	Disruption of the AMPK-TBC1D1 nexus increases lipogenic gene expression and causes obesity in mice via promoting IGF1 secretion.	FASN MTOR SREBF1	3.75e-06	12	91	3	27307439
Pubmed	Rictor phosphorylation on the Thr-1135 site does not require mammalian target of rapamycin complex 2.	MTOR RICTOR	6.77e-06	2	91	2	20501647
Pubmed	Analysis of the mutational status of SIX1/2 and microRNA processing genes in paired primary and relapsed Wilms tumors and association with relapse.	SIX1 SIX2	6.77e-06	2	91	2	33281191
Pubmed	Fat cell-specific ablation of rictor in mice impairs insulin-regulated fat cell and whole-body glucose and lipid metabolism.	MTOR RICTOR	6.77e-06	2	91	2	20332342
Pubmed	mTORC2 sustains thermogenesis via Akt-induced glucose uptake and glycolysis in brown adipose tissue.	MTOR RICTOR	6.77e-06	2	91	2	26772600
Pubmed	Involvement of Rictor/mTORC2 in cardiomyocyte differentiation of mouse embryonic stem cells in vitro.	MTOR RICTOR	6.77e-06	2	91	2	28123351
Pubmed	A carbazole alkaloid deactivates mTOR through the suppression of rictor and that induces apoptosis in lung cancer cells.	MTOR RICTOR	6.77e-06	2	91	2	25893736
Pubmed	Brg1 regulates pro-lipogenic transcription by modulating SREBP activity in hepatocytes.	SREBF1 SMARCA4	6.77e-06	2	91	2	29857051
Pubmed	Targeting mTORC2 inhibits colon cancer cell proliferation in vitro and tumor formation in vivo.	MTOR RICTOR	6.77e-06	2	91	2	20226010
Pubmed	Activation of sterol regulatory element-binding protein 1c and fatty acid synthase transcription by hepatitis C virus non-structural protein 2.	FASN SREBF1	6.77e-06	2	91	2	18420801
Pubmed	Occupancy and function of the -150 sterol regulatory element and -65 E-box in nutritional regulation of the fatty acid synthase gene in living animals.	FASN SREBF1	6.77e-06	2	91	2	12897158
Pubmed	Conditional disruption of rictor demonstrates a direct requirement for mTORC2 in skin tumor development and continued growth of established tumors.	MTOR RICTOR	6.77e-06	2	91	2	25740823
Pubmed	MTOR signaling is essential for the development of thymic epithelial cells and the induction of central immune tolerance.	MTOR RICTOR	6.77e-06	2	91	2	29099279
Pubmed	Reduced expression of FASN through SREBP-1 down-regulation is responsible for hypoxic cell death in HepG2 cells.	FASN SREBF1	6.77e-06	2	91	2	22786746
Pubmed	Glucose-dependent acetylation of Rictor promotes targeted cancer therapy resistance.	MTOR RICTOR	6.77e-06	2	91	2	26170313
Pubmed	Vital roles of mTOR complex 2 in Notch-driven thymocyte differentiation and leukemia.	MTOR RICTOR	6.77e-06	2	91	2	22473959
Pubmed	TOR complex 2 is needed for cell cycle progression and anchorage-independent growth of MCF7 and PC3 tumor cells.	MTOR RICTOR	6.77e-06	2	91	2	18831768
Pubmed	Polyunsaturated fatty acids decrease the expression of sterol regulatory element-binding protein-1 in CaCo-2 cells: effect on fatty acid synthesis and triacylglycerol transport.	FASN SREBF1	6.77e-06	2	91	2	12213084
Pubmed	Acetylcholinesterase level and molecular isoforms are altered in brain of Reelin Orleans mutant mice.	RELN ACHE	6.77e-06	2	91	2	14535959
Pubmed	Control of cortical neuron layering: lessons from mouse chimeras.	RELN CDK5R1	6.77e-06	2	91	2	18494254
Pubmed	A cellular stress response (CSR) that interacts with NADPH-P450 reductase (NPR) is a new regulator of hypoxic response.	POR SCARA3	6.77e-06	2	91	2	24491563
Pubmed	Adipocyte-specific mTORC2 deficiency impairs BAT and iWAT thermogenic capacity without affecting glucose uptake and energy expenditure in cold-acclimated mice.	MTOR RICTOR	6.77e-06	2	91	2	34541875
Pubmed	A DNA polymorphism at the alpha2-macroglobulin gene is associated with the severity of rheumatoid arthritis.	A2M ACE	6.77e-06	2	91	2	11036822
Pubmed	SREBP1 drives Keratin-80-dependent cytoskeletal changes and invasive behavior in endocrine-resistant ERα breast cancer.	SREBF1 KRT80	6.77e-06	2	91	2	31073170
Pubmed	Distinct roles of the mTOR components Rictor and Raptor in MO7e megakaryocytic cells.	MTOR RICTOR	6.77e-06	2	91	2	19341427
Pubmed	Mammalian target of rapamycin protein complex 2 regulates differentiation of Th1 and Th2 cell subsets via distinct signaling pathways.	MTOR RICTOR	6.77e-06	2	91	2	20620941
Pubmed	SREBP1/FASN/cholesterol axis facilitates radioresistance in colorectal cancer.	FASN SREBF1	6.77e-06	2	91	2	33665967
Pubmed	Regulation of SREBP1c expression by mTOR signaling in hepatocytes.	MTOR SREBF1	6.77e-06	2	91	2	20847591
Pubmed	Scavenger receptor-mediated uptake of cell-penetrating peptide nanocomplexes with oligonucleotides.	SCARA5 SCARA3	6.77e-06	2	91	2	22138034
Pubmed	Fatty acid synthase gene is up-regulated by hypoxia via activation of Akt and sterol regulatory element binding protein-1.	FASN SREBF1	6.77e-06	2	91	2	18281474
Pubmed	Insulin-induced de novo lipid synthesis occurs mainly via mTOR-dependent regulation of proteostasis of SREBP-1c.	MTOR SREBF1	6.77e-06	2	91	2	31541353
Pubmed	Mammalian target of rapamycin complex 2 (mTORC2) coordinates pulmonary artery smooth muscle cell metabolism, proliferation, and survival in pulmonary arterial hypertension.	MTOR RICTOR	6.77e-06	2	91	2	24270265
Pubmed	mTOR complex 2 in adipose tissue negatively controls whole-body growth.	MTOR RICTOR	6.77e-06	2	91	2	19497867
Pubmed	Activation of mTORC2 by association with the ribosome.	MTOR RICTOR	6.77e-06	2	91	2	21376236
Pubmed	Sterol regulatory element-binding protein-1/fatty acid synthase involvement in proliferation inhibition and apoptosis promotion induced by progesterone in endometrial cancer.	FASN SREBF1	6.77e-06	2	91	2	24105476
Pubmed	Rictor/mTORC2 pathway in oocytes regulates folliculogenesis, and its inactivation causes premature ovarian failure.	MTOR RICTOR	6.77e-06	2	91	2	25564616
Pubmed	Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy.	GMNC SEC61A2 SYNE3 KCNT2 NOA1 GRIA1 SARDH SUFU SEC22A DSE	1.28e-05	686	91	10	29987050
Pubmed	Identification of FMRP target mRNAs in the developmental brain: FMRP might coordinate Ras/MAPK, Wnt/β-catenin, and mTOR signaling during corticogenesis.	AHI1 MTOR SMARCA4	1.37e-05	18	91	3	33323119
Pubmed	Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.	SLC6A9 RELN ACHE SHBG GRIA1 NLGN2 CHRNG	1.44e-05	300	91	7	19086053
Pubmed	Distribution and association of mTOR with its cofactors, raptor and rictor, in cumulus cells and oocytes during meiotic maturation in mice.	MTOR RICTOR	2.03e-05	3	91	2	23440873
Pubmed	mTOR kinase inhibitors promote antibody class switching via mTORC2 inhibition.	MTOR RICTOR	2.03e-05	3	91	2	25385646
Pubmed	Depletion of Rictor, an essential protein component of mTORC2, decreases male lifespan.	MTOR RICTOR	2.03e-05	3	91	2	25059582
Pubmed	mTOR has a developmental stage-specific role in mitochondrial fitness independent of conventional mTORC1 and mTORC2 and the kinase activity.	MTOR RICTOR	2.03e-05	3	91	2	28813526
Pubmed	The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2.	MTOR RICTOR	2.03e-05	3	91	2	21358638
Pubmed	BRG1, INI1, and ARID1B Deficiency in Endometrial Carcinoma: A Clinicopathologic and Immunohistochemical Analysis of a Large Series From a Single Institution.	ARID1B SMARCA4	2.03e-05	3	91	2	32910019
Pubmed	Muscle inactivation of mTOR causes metabolic and dystrophin defects leading to severe myopathy.	MTOR RICTOR	2.03e-05	3	91	2	20008564
Pubmed	Epithelial-mesenchymal reprogramming by KLF4-regulated Rictor expression contributes to metastasis of non-small cell lung cancer cells.	MTOR RICTOR	2.03e-05	3	91	2	35982899
Pubmed	B7-H3 regulates lipid metabolism of lung cancer through SREBP1-mediated expression of FASN.	FASN SREBF1	2.03e-05	3	91	2	27939887
Pubmed	Proto-oncogene FBI-1 (Pokemon) and SREBP-1 synergistically activate transcription of fatty-acid synthase gene (FASN).	FASN SREBF1	2.03e-05	3	91	2	18682402
Pubmed	Clinical importance of FASN in relation to HIF-1α and SREBP-1c in gastric adenocarcinoma.	FASN SREBF1	2.03e-05	3	91	2	30914315
Pubmed	Deletion of Rictor in neural progenitor cells reveals contributions of mTORC2 signaling to tuberous sclerosis complex.	MTOR RICTOR	2.03e-05	3	91	2	23049074
Pubmed	Basal mTORC2 activity and expression of its components display diurnal variation in mouse perivascular adipose tissue.	MTOR RICTOR	2.03e-05	3	91	2	27016480
Pubmed	Genetic variation in genes of the fatty acid synthesis pathway and breast cancer risk.	FASN SREBF1	2.03e-05	3	91	2	19252981
Pubmed	FAS/SREBP-1c contributes to colorectal carcinogenesis through calcium signaling pathway and cAMP signaling pathway.	FASN SREBF1	2.03e-05	3	91	2	38143182
Pubmed	mTOR complex-2 activates ENaC by phosphorylating SGK1.	MTOR RICTOR	2.03e-05	3	91	2	20338997
Pubmed	TELO2 induced progression of colorectal cancer by binding with RICTOR through mTORC2.	MTOR RICTOR	2.03e-05	3	91	2	33416177
Pubmed	Tumor suppressive effect of scavenger receptor class A member 5 overexpression in colorectal cancer by regulating PI3K/AKT/mTOR pathway.	MTOR SCARA5	2.03e-05	3	91	2	34417976
Pubmed	MicroRNA-let-7a regulates cell autophagy by targeting Rictor in gastric cancer cell lines MGC-803 and SGC-7901.	MTOR RICTOR	2.03e-05	3	91	2	29328491
Pubmed	mTOR phosphorylated at S2448 binds to raptor and rictor.	MTOR RICTOR	2.03e-05	3	91	2	19145465
Pubmed	Morin Acts as a USP7 Inhibitor to Hold Back the Migration of Rheumatoid Arthritis Fibroblast-Like Synoviocytes in a "Prickle1-mTORC2" Dependent Manner.	MTOR RICTOR	2.03e-05	3	91	2	34331380
Pubmed	T-cell-specific mTOR deletion in mice ameliorated CD4+ T-cell survival in lethal sepsis induced by severe invasive candidiasis.	MTOR RICTOR	2.03e-05	3	91	2	31668132
Pubmed	Coffin-Siris syndrome is a SWI/SNF complex disorder.	ARID1B SMARCA4	2.03e-05	3	91	2	23815551
Pubmed	Association of genetic polymorphisms in HSD17B1, HSD17B2 and SHBG genes with hepatocellular carcinoma risk.	SHBG HSD17B2	2.03e-05	3	91	2	24563232
Pubmed	SREBF1 Activity Is Regulated by an AR/mTOR Nuclear Axis in Prostate Cancer.	MTOR SREBF1	2.03e-05	3	91	2	29784665
Pubmed	Genome-wide shRNA screen reveals increased mitochondrial dependence upon mTORC2 addiction.	MTOR RICTOR	2.03e-05	3	91	2	21170086
Pubmed	Expression of the mTOR pathway regulators in human pituitary adenomas indicates the clinical course.	MTOR RICTOR	2.03e-05	3	91	2	23898069
Pubmed	Low pretreatment serum globulin may predict favorable prognosis for gastric cancer patients.	A2M SHBG	2.03e-05	3	91	2	26476541
Pubmed	mTOR Driven Gene Transcription Is Required for Cholesterol Production in Neurons of the Developing Cerebral Cortex.	MTOR SREBF1	2.03e-05	3	91	2	34204880
Pubmed	Myopathy caused by mammalian target of rapamycin complex 1 (mTORC1) inactivation is not reversed by restoring mitochondrial function.	MTOR RICTOR	2.03e-05	3	91	2	22143799
Pubmed	Involvement of mTORC1 and mTORC2 in regulation of glioblastoma multiforme growth and motility.	MTOR RICTOR	2.03e-05	3	91	2	19724909
Pubmed	Cytoplasmic and nuclear distribution of the protein complexes mTORC1 and mTORC2: rapamycin triggers dephosphorylation and delocalization of the mTORC2 components rictor and sin1.	MTOR RICTOR	2.03e-05	3	91	2	18614546
Pubmed	Histone modifications in FASN modulated by sterol regulatory element-binding protein 1c and carbohydrate responsive-element binding protein under insulin stimulation are related to NAFLD.	FASN SREBF1	2.03e-05	3	91	2	28027934
Pubmed	Metformin targets Clusterin to control lipogenesis and inhibit the growth of bladder cancer cells through SREBP-1c/FASN axis.	FASN SREBF1	2.03e-05	3	91	2	33649289
Pubmed	Critical roles of mTOR Complex 1 and 2 for T follicular helper cell differentiation and germinal center responses.	MTOR RICTOR	2.03e-05	3	91	2	27690224
Pubmed	Molecular effects of Eya1 domain mutations causing organ defects in BOR syndrome.	SIX1 SIX2	2.03e-05	3	91	2	11734542
Pubmed	mTORC2 signalling regulates M2 macrophage differentiation in response to helminth infection and adaptive thermogenesis.	MTOR RICTOR	2.03e-05	3	91	2	28128208
Pubmed	Rictor regulates FBXW7-dependent c-Myc and cyclin E degradation in colorectal cancer cells.	MTOR RICTOR	2.03e-05	3	91	2	22285861
Pubmed	Mutation in the transcriptional coactivator EYA4 causes dilated cardiomyopathy and sensorineural hearing loss.	SIX1 SIX2	2.03e-05	3	91	2	15735644
Pubmed	Cardiac mTOR complex 2 preserves ventricular function in pressure-overload hypertrophy.	MTOR RICTOR	2.03e-05	3	91	2	26598511
Pubmed	Mutations affecting components of the SWI/SNF complex cause Coffin-Siris syndrome.	ARID1B SMARCA4	2.03e-05	3	91	2	22426308
Pubmed	mTOR complex component Rictor interacts with PKCzeta and regulates cancer cell metastasis.	MTOR RICTOR	2.03e-05	3	91	2	20978191
Pubmed	Langerhans cell homeostasis in mice is dependent on mTORC1 but not mTORC2 function.	MTOR RICTOR	2.03e-05	3	91	2	23212520
Pubmed	mTOR direct crosstalk with STAT5 promotes de novo lipid synthesis and induces hepatocellular carcinoma.	MTOR SREBF1	2.03e-05	3	91	2	31409773
Pubmed	Angiotensin-converting enzyme and alpha-2-macroglobulin gene polymorphisms are not associated with Alzheimer's disease in Colombian patients.	A2M ACE	2.03e-05	3	91	2	14759632
Pubmed	mTORC1 maintains renal tubular homeostasis and is essential in response to ischemic stress.	MTOR RICTOR	2.03e-05	3	91	2	24958889
Pubmed	Regulation of fatty acid synthase expression in breast cancer by sterol regulatory element binding protein-1c.	FASN SREBF1	2.03e-05	3	91	2	12531699
Pubmed	Genes related to sex steroids, neural growth, and social-emotional behavior are associated with autistic traits, empathy, and Asperger syndrome.	SHBG POR CALCRL HSD17B2	2.63e-05	65	91	4	19598235
Pubmed	Interaction between NBS1 and the mTOR/Rictor/SIN1 complex through specific domains.	MTOR RICTOR	4.05e-05	4	91	2	23762398
Pubmed	mTORC1-independent autophagy regulates receptor tyrosine kinase phosphorylation in colorectal cancer cells via an mTORC2-mediated mechanism.	MTOR RICTOR	4.05e-05	4	91	2	28475179
Pubmed	Cortical malformations and epilepsy: new insights from animal models.	RELN CDK5R1	4.05e-05	4	91	2	10403203
Pubmed	Inhibition of DNA-dependent protein kinase reduced palmitate and oleate-induced lipid accumulation in HepG2 cells.	FASN SREBF1	4.05e-05	4	91	2	23184344
Pubmed	Ribavirin enhances interferon signaling via stimulation of mTOR and p53 activities.	MTOR RICTOR	4.05e-05	4	91	2	19619545
Pubmed	Pathological Ace2-to-Ace enzyme switch in the stressed heart is transcriptionally controlled by the endothelial Brg1-FoxM1 complex.	SMARCA4 ACE	4.05e-05	4	91	2	27601681
Pubmed	γ-Tocotrienol attenuates triglyceride through effect on lipogenic gene expressions in mouse hepatocellular carcinoma Hepa 1-6.	FASN SREBF1	4.05e-05	4	91	2	23727646
Pubmed	HCBP6 Modulates Triglyceride Homeostasis in Hepatocytes Via the SREBP1c/FASN Pathway.	FASN SREBF1	4.05e-05	4	91	2	25855506
Pubmed	CMPK1 and RBP3 are associated with corneal curvature in Asian populations.	CMPK1 MTOR	4.05e-05	4	91	2	24963161
Pubmed	TGF-β-induced activation of mTOR complex 2 drives epithelial-mesenchymal transition and cell invasion.	MTOR RICTOR	4.05e-05	4	91	2	22399812
Interaction	TOP3B interactions	CCDC142 PCNX2 USP10 FASN CDK5R1 NADSYN1 SYNE3 PCNX3 TRIO PIK3C2B MTOR XPO6 RTTN SREBF1 PCNX1 NLGN2 SFI1 MLLT10 SUFU ABCA7 SCARA3 DYNC1H1	3.56e-07	1470	90	22	int:TOP3B
Cytoband	6q25.1	CCDC170 ARID1B NUP43	6.04e-05	38	91	3	6q25.1
GeneFamily	MTOR complex 1\|MTOR complex 2	MTOR RICTOR	1.01e-04	5	58	2	1333
GeneFamily	SINE class homeoboxes	SIX1 SIX2	1.50e-04	6	58	2	525
GeneFamily	EF-hand domain containing\|Spectrins	SPTBN5 SPTA1	2.10e-04	7	58	2	1113
GeneFamily	C2-set domain containing\|Immunoglobulin like domain containing\|Scavenger receptors	SCARA5 SCARA3	3.37e-03	27	58	2	1253
ToppCell	Parenchymal-10x3prime_v2-Stromal-Fibroblastic-Fibro_myofibroblast\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	A2M COL6A2 THBS2 KCNT2 DAAM2 SCARA3 DSE	1.82e-07	200	91	7	251fd2923f108cd2086961d897244b392c32ad54
ToppCell	P15-Epithelial-airway_epithelial_cell-ciliated_cell_of_airway\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	PCNX3 PIK3C2B SCNN1B DAAM2 SFI1 ABCA7	1.23e-06	167	91	6	5c3d0763f73628c71c71f9883556bb4f1639f3cc
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-kidney_interstitial_fibroblast_5\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	A2M COL6A2 NUP43 DAAM2 NLGN2 PLOD1	1.41e-06	171	91	6	2a34685f7d83d1cf9a88d304173cbca868c5f9fd
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	A2M GMNC RELN SPTA1 SFI1 ADGRV1	2.15e-06	184	91	6	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	A2M GMNC RELN SPTA1 SFI1 ADGRV1	2.15e-06	184	91	6	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	A2M GMNC RELN SPTA1 SFI1 ADGRV1	2.15e-06	184	91	6	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	facs-Mammary_Gland-Mammary_Gland-3m-Mesenchymal-stromal_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL6A2 THBS2 SCARA5 CALCRL ACE SCARA3	2.22e-06	185	91	6	3cd0686a14e734a0f243070ab939adcb4c454478
ToppCell	facs-Mammary_Gland-Mammary_Gland-3m-Mesenchymal-stromal_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL6A2 THBS2 SCARA5 CALCRL ACE SCARA3	2.22e-06	185	91	6	00258f458cbf6d36449db95528a6b5038d731d2d
ToppCell	facs-Mammary_Gland-Mammary_Gland-3m-Mesenchymal\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL6A2 THBS2 SCARA5 CALCRL ACE SCARA3	2.22e-06	185	91	6	a94694e226856bc5b168464f52d76004145717a5
ToppCell	3'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_2_(NPY+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	A2M COL6A2 SCARA5 DAAM2 HSD17B2 DSE	2.29e-06	186	91	6	d3509a579871ba6a8c4edd6137b28f271c9dbe70
ToppCell	PND07-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	COL6A2 THBS2 KCNT2 TRIO SCARA5 SCARA3	2.67e-06	191	91	6	9f478f36a0b895e607e3bb77fa0f9f03cc0f33fc
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCNX2 CDK5R1 AHI1 TSPOAP1 GRIA1 ATP2B2	2.84e-06	193	91	6	be28070c049e7cb68bcd54f582226eb2f5e4bc1c
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCNX2 CDK5R1 AHI1 TSPOAP1 GRIA1 ATP2B2	2.84e-06	193	91	6	0c652ebe22ce5d2927599dd97ef1920547858395
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Neuronal-neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCNX2 CDK5R1 AHI1 TSPOAP1 GRIA1 ATP2B2	2.84e-06	193	91	6	8689a70a33a7c3823dc647d41ac0160e7c3ae396
ToppCell	wk_08-11-Hematologic-Meg-ery-Definitive_erythroblast\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	SLC6A9 RELN SYNE3 SPTA1 RICTOR ABCA7	2.84e-06	193	91	6	be75abfdf5301cf33df8ee9ed92504d44fdf19a6
ToppCell	PND07-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_mature\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	COL6A2 THBS2 KCNT2 TRIO SCARA5 SCARA3	2.84e-06	193	91	6	051f61156b0e2e95292b2d8377faf3190b50f264
ToppCell	3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	A2M COL6A2 THBS2 KCNT2 DAAM2 SCARA3	2.92e-06	194	91	6	8fae8061b350336299aa81f378e07deadbd55123
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	CCDC170 A2M COL6A2 KCNT2 DAAM2 HSD17B2	2.92e-06	194	91	6	90efdbd7f1c85fd7fd622b10340250b1d8fc1197
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	CCDC170 A2M COL6A2 KCNT2 DAAM2 HSD17B2	2.92e-06	194	91	6	df82cce5ebeb73740b02cf816c6df82253cfd566
ToppCell	3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	A2M COL6A2 THBS2 KCNT2 DAAM2 SCARA3	2.92e-06	194	91	6	4d7d24390fdb379f943ddcc70a63f23955e10163
ToppCell	mild-low-quality_cells\|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	A2M DLG5 ARID1B RTTN PCSK7 SFI1	3.19e-06	197	91	6	e4331969bd911d1ebb5453f40a7057297b5389b4
ToppCell	mild-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	A2M ARID1B RTTN PCSK7 RICTOR SFI1	3.39e-06	199	91	6	f0b0097df0026496470a80d8cc9375ffd8389b00
ToppCell	Bronchial-NucSeq-Stromal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	A2M COL6A2 THBS2 KCNT2 SCARA5 GRIA1	3.48e-06	200	91	6	389cc775c8419d90fb77cd794376d2160a7bf44e
ToppCell	COVID-19_Mild\|World / 5 Neutrophil clusters in COVID-19 patients	DLG5 RELN TSPOAP1 PCNX1 ADGRV1	1.52e-05	152	91	5	2ff0980dfd8d430cca14649151d856edef115720
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FASN THBS2 SCARA5 GRIA1 SIX1	2.00e-05	161	91	5	a006491c991e6a134be20ad75092a91f3b7c3c91
ToppCell	AT1_cells-IPF_01\|World / lung cells shred on cell class, cell subclass, sample id	KCNT2 ACHE C1orf167 ABCA7 KRT80	2.06e-05	162	91	5	ae2ba4f21f6f6c512006fa531d670b88be7c04c9
ToppCell	LPS_only-Epithelial_airway-Club_cells-Airway\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SCNN1B HSD17B2 SIX1 SIX2 KRT80	2.19e-05	164	91	5	b1243b10591e1e15a94952e39ffbf382eae6aae8
ToppCell	LPS_only-Epithelial_airway-Club_cells\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SCNN1B HSD17B2 SIX1 SIX2 KRT80	2.19e-05	164	91	5	c5b2001280a43da855017361a3f6071a0e492848
ToppCell	droplet-Marrow-BM-30m-Lymphocytic-NK_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TSPOAP1 ADGRV1 ACE DSE KRT80	2.19e-05	164	91	5	b77995958c938e10a526118f75d78cee72e0b207
ToppCell	LPS_only-Epithelial_airway\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SCNN1B HSD17B2 SIX1 SIX2 KRT80	2.19e-05	164	91	5	56e6934e6c7503a300d7be06762d45a1d6f1ae0f
ToppCell	facs-Heart-RV-24m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GMNC COL6A2 THBS2 SCARA5 CES3	2.38e-05	167	91	5	3e3d8f6df2feefafad5b44ba0ebf5b5a0fe4ed58
ToppCell	facs-Heart-RV-24m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GMNC COL6A2 THBS2 SCARA5 CES3	2.38e-05	167	91	5	3ad9f3122dbe96580f640388ef920ea209fc2349
ToppCell	367C-Fibroblasts-Fibroblast-G\|367C / Donor, Lineage, Cell class and subclass (all cells)	A2M SLC6A9 COL6A2 GRIA1 HSD17B2	2.45e-05	168	91	5	8c95093b1ea45826f62893edd3c410fe53b563a4
ToppCell	367C-Fibroblasts-Fibroblast-G-\|367C / Donor, Lineage, Cell class and subclass (all cells)	A2M SLC6A9 COL6A2 GRIA1 HSD17B2	2.45e-05	168	91	5	b8c65542a0701ae31f49d332d87a64578e24b4e3
ToppCell	10x3'2.3-week_12-13-Myeloid_DC-DC-DC1\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	PCNX2 MALRD1 RAB32 PIGZ DSE	2.67e-05	171	91	5	04346d4eb726875e3537e215ea081a0318ca4ddd
ToppCell	COVID-19-Heart-T_cell\|COVID-19 / Disease (COVID-19 only), tissue and cell type	RELN ATP8A2 SPTA1 TNR ATP2B2	2.67e-05	171	91	5	b2e753e811a7639956994609f73efcdb62d04f82
ToppCell	3'-Broncho-tracheal-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	COL6A2 THBS2 KCNT2 TRIO SCARA5	2.75e-05	172	91	5	e37c0b5b547a7345179ab258dd2141fec7064c17
ToppCell	Children_(3_yrs)-Mesenchymal-myofibroblast_cell-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	A2M THBS2 KCNT2 DAAM2 SCARA3	2.82e-05	173	91	5	1f16d47f5548e257e4b17f8070c5619780a9c5fd
ToppCell	droplet-Marrow-nan-3m-Lymphocytic-NK_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RASA2 PIK3C2B PCNX1 ACE KRT80	2.98e-05	175	91	5	cf53a15bfb37b6019e7052ffdf594a9ac040900e
ToppCell	facs-Heart-RV-18m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL6A2 THBS2 SCARA5 ACE SCARA3	3.07e-05	176	91	5	c0a084f7a8645262d61971f094689e02bf15b113
ToppCell	facs-Heart-RV-18m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL6A2 THBS2 SCARA5 ACE SCARA3	3.07e-05	176	91	5	cccf9201f6e2da7524b911a5961d3b227edab222
ToppCell	wk_15-18-Epithelial-Proximal_epithelial-Proximal_secretory_3\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	GMNC SCNN1B SIX1 SIX2 KRT80	3.07e-05	176	91	5	8d9d0fb46c418b2067be58aec822e8c2b1561461
ToppCell	343B-Fibroblasts-Fibroblast-A_(Fibroblast_progenitors)-\|343B / Donor, Lineage, Cell class and subclass (all cells)	A2M COL6A2 THBS2 SCARA5 SCARA3	3.07e-05	176	91	5	2e94bbe17c0bb65dc58b4ebc0cb829258bd7373b
ToppCell	PND07-28-samps-Mesenchymal-Myofibroblast-myofibroblast_-_mature_-_DCN\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	COL6A2 THBS2 KCNT2 SCARA5 SCARA3	3.07e-05	176	91	5	08f94b78b27feeb113dbfadbfa7fe34d08b2809b
ToppCell	343B-Fibroblasts-Fibroblast-A_(Fibroblast_progenitors)\|343B / Donor, Lineage, Cell class and subclass (all cells)	A2M COL6A2 THBS2 SCARA5 SCARA3	3.07e-05	176	91	5	f33ab41d121b59d871ad7d48ca021524a027d2ef
ToppCell	Posterior_cortex-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Syt6-Excitatory_Neuron.Slc17a7-Slc17a8.Syt6-Lancl3_(Cortical_Subplate_pyramidal_cells)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	CCDC142 SCARA5 HSD17B2 KRT80	3.21e-05	88	91	4	fcc15c5c30517c63a835b28627c5f779d9bcd17e
ToppCell	Posterior_cortex-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Syt6-Excitatory_Neuron.Slc17a7-Slc17a8.Syt6-Lancl3_(Cortical_Subplate_pyramidal_cells)-\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	CCDC142 SCARA5 HSD17B2 KRT80	3.21e-05	88	91	4	7838c65160cf81c02b923fc34f566c0610c8d81b
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m-Neuronal-neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL6A2 RELN CDK5R1 ACHE GRIA1	3.32e-05	179	91	5	479116ac65488c60104a053530830763ec1f95b2
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL6A2 RELN CDK5R1 ACHE GRIA1	3.32e-05	179	91	5	1dfc0cb8b369aef35c59f3d4c52603dc9f3728c1
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL6A2 RELN CDK5R1 ACHE GRIA1	3.32e-05	179	91	5	69a1b3b05c921de6343ffe6ad998aa2b804312a7
ToppCell	Children_(3_yrs)-Mesenchymal-myofibroblast_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	A2M THBS2 KCNT2 DAAM2 SCARA3	3.41e-05	180	91	5	01f2e5d96016823482f89ba503d007d4bd88eeac
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	A2M COL6A2 THBS2 KCNT2 SIX1	3.50e-05	181	91	5	c6d2a13df3b74fade3b0c71e285b4c14c8e52413
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	A2M COL6A2 THBS2 KCNT2 SIX1	3.50e-05	181	91	5	c62b0a2422377ffadaab63edd538e87a06fa5017
ToppCell	Fetal_29-31_weeks-Mesenchymal-myofibroblast_cell-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	COL6A2 THBS2 KCNT2 TRIO SCARA3	3.60e-05	182	91	5	ed6ae0fd8653f213fe29906a6a4e0729a62e1b75
ToppCell	LPS_only-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	NDST3 NELL1 DAAM2 NLGN2 SCARA3	3.69e-05	183	91	5	12daaea821e49bc94a01e2496331e92a80d27339
ToppCell	COVID-19-Fibroblasts-Adventitial_FB\|COVID-19 / group, cell type (main and fine annotations)	A2M COL6A2 THBS2 KCNT2 SCARA5	3.89e-05	185	91	5	a5aebf2b9b05b550d021272731d68af9a6b1229d
ToppCell	facs-MAT-Fat-3m-Epithelial-nan\|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NDST3 SPTA1 ADGRV1 TNR	3.98e-05	93	91	4	dbfaa7f23d25f5c286ab7ca3ca795b734cb95153
ToppCell	facs-MAT-Fat-3m-Epithelial-epithelial_cell\|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NDST3 SPTA1 ADGRV1 TNR	3.98e-05	93	91	4	0d6d1d8dd9c91ba31eb35a4b5979d087890936c1
ToppCell	facs-MAT-Fat-3m-Epithelial\|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NDST3 SPTA1 ADGRV1 TNR	3.98e-05	93	91	4	abffb1fd5a919b7c08e62e1c3c08a8dd8783a4ca
ToppCell	5'-GW_trimst-2-LargeIntestine-Mesenchymal-fibroblastic-Stromal_2_(CH25H+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NELL1 COL6A2 AHI1 HSD17B2 PLOD1	3.99e-05	186	91	5	360c3e9e5c3a943e68e6939b4a47821bfc75b553
ToppCell	5'-Adult-Distal_Rectal-Mesenchymal-fibroblastic-Stromal_1_(CCL11+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	A2M TRIL COL6A2 KCNT2 SCARA5	3.99e-05	186	91	5	f07e0c0d9c80ac9d8d679950e7d0c812becb85a3
ToppCell	kidney_cells-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	A2M COL6A2 ATP8A2 DAAM2 DSE	4.09e-05	187	91	5	d591a3c216997663ab77710fed0d230ffc37e41a
ToppCell	droplet-Liver-HEPATOCYTES-1m-Mesenchymal-hepatic_stellate_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL6A2 RELN THBS2 ACHE DAAM2	4.09e-05	187	91	5	b6ecf55014f246461bf1ca12f24cb4d046661fa4
ToppCell	Adult-Epithelial-club_cell-D231\|Adult / Lineage, Cell type, age group and donor	NELL1 SCNN1B ADGRV1 HSD17B2 SIX1	4.09e-05	187	91	5	ee59d7d3de5879738ff0b9c3ea5e4847fb48cb86
ToppCell	droplet-Liver-HEPATOCYTES-1m-Mesenchymal-hepatic_stellate_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL6A2 RELN THBS2 ACHE DAAM2	4.09e-05	187	91	5	9fb15f24b9b364b0c4704ec98aec236eaec5411c
ToppCell	kidney_cells-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	A2M COL6A2 ATP8A2 DAAM2 DSE	4.09e-05	187	91	5	d1dc8c9a2c2cd10c640257161a75e7730ec5bb41
ToppCell	kidney_cells-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	A2M COL6A2 ATP8A2 DAAM2 DSE	4.09e-05	187	91	5	ac8e092b37e042975e2ee057d3f7c6821e58e8b5
ToppCell	droplet-Liver-HEPATOCYTES-1m-Mesenchymal\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL6A2 RELN THBS2 ACHE DAAM2	4.09e-05	187	91	5	e6afbaed352310a1cb49571a2aae18be1f533c9a
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_2_(NPY+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	A2M COL6A2 ATP8A2 DAAM2 DSE	4.20e-05	188	91	5	997dcfc4f08738ab398d8abc15e4fd2fc6619862
ToppCell	Mesenchymal-chondrocyte\|World / Lineage, Cell type, age group and donor	A2M COL6A2 KCNT2 DAAM2 SCARA3	4.20e-05	188	91	5	7b1e3f8a941eaa68e89c562129a92314642eec66
ToppCell	Globus_pallidus-Neuronal\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	PCNX2 CDK5R1 TSPOAP1 ATP2B2 SLC7A14	4.41e-05	190	91	5	416de85d8841dac883faa6f5339b2fb461a09e82
ToppCell	droplet-Limb_Muscle-nan-24m-Mesenchymal-mesenchymal_stem_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL6A2 THBS2 SCARA5 ACE SCARA3	4.41e-05	190	91	5	ad0f5605db6b694445ec9bd5dc8d2d834358c0f9
ToppCell	droplet-Mammary_Gland-nan-18m-Mesenchymal-stromal_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL6A2 THBS2 SCARA5 ACE SCARA3	4.41e-05	190	91	5	47077579496c5340e99f61499427a3a36b566da3
ToppCell	droplet-Mammary_Gland-nan-18m-Mesenchymal-stromal_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL6A2 THBS2 SCARA5 ACE SCARA3	4.53e-05	191	91	5	a57cf0519d749febc0b69fe0b098b7ba53d63258
ToppCell	facs-Pancreas-Endocrine-24m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NELL1 RELN SCNN1B USP35 SLC7A14	4.53e-05	191	91	5	3387b95a3f2445c672d407922fdce3a91eabaef8
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	A2M COL6A2 THBS2 KCNT2 DAAM2	4.53e-05	191	91	5	39092a0aff8097617820c59f5fea9ee2bb4f63a2
ToppCell	droplet-Mammary_Gland-nan-18m-Mesenchymal\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL6A2 THBS2 SCARA5 ACE SCARA3	4.53e-05	191	91	5	19c67a812b8ce97472d316acd15aeefe8736000d
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	A2M COL6A2 THBS2 KCNT2 DAAM2	4.53e-05	191	91	5	ee5f1b1c59029c46cbb1a00935c03b9317bb9da9
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	A2M COL6A2 THBS2 KCNT2 DAAM2	4.64e-05	192	91	5	5105e4b577408b4e1a62d0a44c23c2b830ccad88
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	A2M COL6A2 THBS2 KCNT2 DAAM2	4.64e-05	192	91	5	d3c1ad4667a1e223a83ca0fcd5991a0b96f1199a
ToppCell	facs-Limb_Muscle-ForelimbandHindlimb-3m-Mesenchymal-mesenchymal_stem_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL6A2 SCARA5 ACE PLOD1 SCARA3	4.64e-05	192	91	5	beac6b3c191b11add8e39e8d04562b478ea8929e
ToppCell	LPS-IL1RA-Stromal_mesenchymal\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	NELL1 COL6A2 THBS2 DAAM2 SCARA3	4.64e-05	192	91	5	4e47a02007f562f29ba5910df64d32a0167d0bd1
ToppCell	3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts-Peribronchial_fibroblasts_L.2.1.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	A2M COL6A2 THBS2 KCNT2 SCARA5	4.64e-05	192	91	5	c5f8e766453f87847b740d6988c524b3d0ef3765
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	A2M COL6A2 KCNT2 DAAM2 HSD17B2	4.76e-05	193	91	5	f1199518c3626fd29bfce65070dd21a660671213
ToppCell	LV-01._Fibroblast_I\|LV / Chamber and Cluster_Paper	COL6A2 KCNT2 SCARA5 CHD9 CALCRL	4.76e-05	193	91	5	dc17f3b9758936d428cf17f77a1ce6d4c479b165
ToppCell	RV-02._Fibroblast_II\|RV / Chamber and Cluster_Paper	COL6A2 KCNT2 SCARA5 CHD9 CALCRL	4.87e-05	194	91	5	11c79a8c56ece42713b04b321982e41e239f07a5
ToppCell	LV-02._Fibroblast_II\|LV / Chamber and Cluster_Paper	COL6A2 KCNT2 SCARA5 CHD9 CALCRL	4.87e-05	194	91	5	014d2feb5db2a6a35ef759761a41e466e108c3c1
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CCDC170 A2M THBS2 KCNT2 DAAM2	4.87e-05	194	91	5	cf0244a29934e515446ac917d3c30672b460fb04
ToppCell	COVID-19-Heart-Fib_2\|Heart / Disease (COVID-19 only), tissue and cell type	PCNX2 COL6A2 THBS2 KCNT2 SCARA5	4.87e-05	194	91	5	d91c9f2ec47319051fc398320693fddbe8bbd4d6
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	A2M COL6A2 THBS2 KCNT2 DAAM2	4.87e-05	194	91	5	e03ba6caed59fa64d4d9b042593469d4a6a3dc10
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CCDC170 A2M THBS2 KCNT2 DAAM2	4.87e-05	194	91	5	ba7f971fb9a19423602da60770f23d9fead4a451
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	A2M COL6A2 THBS2 KCNT2 DAAM2	4.87e-05	194	91	5	ebb038f94f49f5c655578d1b018676e10c6b7e3c
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	A2M COL6A2 THBS2 KCNT2 DAAM2	4.99e-05	195	91	5	edd4cd8402af81737b2074f9dce71cc6ab09be7e
ToppCell	RV-02._Fibroblast_II\|World / Chamber and Cluster_Paper	COL6A2 KCNT2 SCARA5 CHD9 CALCRL	4.99e-05	195	91	5	ce90b30dcdb56d4cd925cdb79fd9d7cefd998f48
ToppCell	RA-02._Fibroblast_II\|RA / Chamber and Cluster_Paper	COL6A2 ARID1B KCNT2 SCARA5 CHD9	4.99e-05	195	91	5	6a02ebbeb3199447ddce64d92d8809436e040eba
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	A2M COL6A2 KCNT2 DAAM2 HSD17B2	5.12e-05	196	91	5	2b36b9a40fe415917afccff99ad9c3474e087d0d
ToppCell	facs-Aorta-Heart-3m-Mesenchymal-fibroblast_of_cardiac_tissue\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL6A2 THBS2 SCARA5 POR SCARA3	5.12e-05	196	91	5	2029f58ce6a7b8c35d3a7496c3341391990909ce
ToppCell	nucseq-Mesenchymal-Fibroblastic\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	A2M COL6A2 THBS2 SCARA5 GRIA1	5.12e-05	196	91	5	7d8505dac15fa59935ccf592afc54b04c4c6554f
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	A2M COL6A2 THBS2 DAAM2 HSD17B2	5.24e-05	197	91	5	6d027119a5f7ca2aac1b10837e43f9a2bb54db85
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	A2M COL6A2 THBS2 KCNT2 DAAM2	5.24e-05	197	91	5	ae0435f4b4a9cdedb1c201fc56921048390097bf
Drug	phosalone	A2M MTOR ACHE ATP8A2	2.88e-07	15	89	4	CID000004793
Drug	pyrenebutyl methylphosphonofluoridate	A2M FASN ACHE	4.77e-06	9	89	3	CID000125653
Drug	chlorpyrifos-methyl	ACHE ATP8A2 SHBG	6.79e-06	10	89	3	CID000021803
Drug	Pyrazinamide [ 98-96-4]; Up 200; 32.4uM; MCF7; HT_HG-U133A	DLG5 AHI1 TRIO PCNX1 ABCA7 SCARA3 CHRNG	1.32e-05	199	89	7	4962_UP
Drug	carmustine; Down 200; 100uM; MCF7; HT_HG-U133A	PCNX2 A2M CDK5R1 AHI1 SREBF1 PCNX1 SFI1	1.32e-05	199	89	7	6888_DN
Disease	Schizophrenia	SHANK1 NDST3 SLC6A9 RELN CDK5R1 AHI1 MTOR ACHE SREBF1 GRIA1 DAAM2 NLGN2 ACE	2.44e-06	883	89	13	C0036341
Disease	Acute Confusional Senile Dementia	A2M RELN ACHE ACE ABCA7	1.27e-05	99	89	5	C0546126
Disease	Alzheimer's Disease, Focal Onset	A2M RELN ACHE ACE ABCA7	1.27e-05	99	89	5	C0750900
Disease	Alzheimer Disease, Early Onset	A2M RELN ACHE ACE ABCA7	1.27e-05	99	89	5	C0750901
Disease	Presenile dementia	A2M RELN ACHE ACE ABCA7	1.27e-05	99	89	5	C0011265
Disease	Alzheimer Disease, Late Onset	A2M RELN ACHE ACE ABCA7	1.27e-05	99	89	5	C0494463
Disease	Familial Alzheimer Disease (FAD)	A2M RELN ACHE ACE ABCA7	1.34e-05	100	89	5	C0276496
Disease	Alzheimer's Disease	A2M RELN ACHE ACE ABCA7	1.41e-05	101	89	5	C0002395
Disease	cerebellar ataxia, mental retardation and dysequlibrium syndrome (is_implicated_in)	ATP8A2 WDR81	5.38e-05	4	89	2	DOID:0050997 (is_implicated_in)
Disease	Intellectual Disability	FASN AHI1 TRIO MTOR ATP8A2 RTTN GRIA1 DYNC1H1	6.30e-05	447	89	8	C3714756
Disease	Dysequilibrium syndrome	ATP8A2 WDR81	8.94e-05	5	89	2	C0394006
Disease	MENTAL RETARDATION, AUTOSOMAL DOMINANT 12	ARID1B SMARCA4	8.94e-05	5	89	2	C3281201
Disease	Developmental Academic Disorder	ACHE POR GRIA1	9.16e-05	29	89	3	C1330966
Disease	Learning Disorders	ACHE POR GRIA1	9.16e-05	29	89	3	C0023186
Disease	Learning Disturbance	ACHE POR GRIA1	9.16e-05	29	89	3	C0751263
Disease	Adult Learning Disorders	ACHE POR GRIA1	9.16e-05	29	89	3	C0751262
Disease	Learning Disabilities	ACHE POR GRIA1	9.16e-05	29	89	3	C0751265
Disease	autism spectrum disorder (implicated_via_orthology)	SHANK1 NDST3 ARID1B CHD9 NLGN2	9.95e-05	152	89	5	DOID:0060041 (implicated_via_orthology)
Disease	cancer (implicated_via_orthology)	CMPK1 ARID1B CENPA MTOR SMARCA4 PIGZ	1.64e-04	268	89	6	DOID:162 (implicated_via_orthology)
Disease	vitamin D deficiency	NADSYN1 SMARCA4 PCNX1	1.91e-04	37	89	3	EFO_0003762
Disease	male breast carcinoma	CCDC170 MLLT10	2.49e-04	8	89	2	EFO_0006861
Disease	Carcinoma, Small Cell	MTOR SMARCA4	3.19e-04	9	89	2	C0262584
Disease	Kidney Failure, Chronic	FASN SREBF1 ACE	4.16e-04	48	89	3	C0022661
Disease	cortical thickness	A2M GMNC NELL1 RELN ARID1B MALRD1 SREBF1 USP35 ADGRV1 CALCRL MLLT10	5.19e-04	1113	89	11	EFO_0004840
Disease	myeloid white cell count	DLG5 AHI1 RASA2 XPO6 TADA2B SREBF1 CES3 CALCRL TNR ABCA7	5.24e-04	937	89	10	EFO_0007988
Disease	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	MTOR SMARCA4 MLLT10	5.57e-04	53	89	3	C1961099
Disease	Sarcomatoid Renal Cell Carcinoma	SHANK1 MTOR ACHE MLLT10	6.20e-04	128	89	4	C1266043
Disease	Chromophobe Renal Cell Carcinoma	SHANK1 MTOR ACHE MLLT10	6.20e-04	128	89	4	C1266042
Disease	Collecting Duct Carcinoma of the Kidney	SHANK1 MTOR ACHE MLLT10	6.20e-04	128	89	4	C1266044
Disease	Papillary Renal Cell Carcinoma	SHANK1 MTOR ACHE MLLT10	6.20e-04	128	89	4	C1306837
Disease	Renal Cell Carcinoma	SHANK1 MTOR ACHE MLLT10	6.20e-04	128	89	4	C0007134
Disease	Coffin-Siris syndrome	ARID1B SMARCA4	6.87e-04	13	89	2	C0265338
Disease	Malformations of Cortical Development	MTOR DYNC1H1	8.00e-04	14	89	2	C1955869
Disease	Cortical Dysplasia	MTOR DYNC1H1	8.00e-04	14	89	2	C0431380
Disease	Liver carcinoma	A2M FASN ARID1B CENPA MTOR SREBF1 ACE	8.69e-04	507	89	7	C2239176
Disease	response to irinotecan	TRIL SYNE3	9.21e-04	15	89	2	EFO_0004829
Disease	autosomal recessive polycystic kidney disease (implicated_via_orthology)	MTOR ACE	1.05e-03	16	89	2	DOID:0110861 (implicated_via_orthology)
Disease	Conventional (Clear Cell) Renal Cell Carcinoma	SHANK1 MTOR ACHE MLLT10	1.07e-03	148	89	4	C0279702
Disease	schizophrenia (implicated_via_orthology)	RELN MTOR NLGN2	1.15e-03	68	89	3	DOID:5419 (implicated_via_orthology)
Disease	Autistic Disorder	SHANK1 RELN AHI1 GRIA1 ACE	1.18e-03	261	89	5	C0004352
Disease	autosomal dominant intellectual developmental disorder (is_implicated_in)	TRIO GRIA1	1.19e-03	17	89	2	DOID:0060307 (is_implicated_in)
Disease	ischemia (implicated_via_orthology)	ARID1B SCNN1B	1.19e-03	17	89	2	DOID:326 (implicated_via_orthology)
Disease	complex trait	CENPA RASA2 ACHE OASL PCSK7	1.39e-03	271	89	5	EFO_0010578
Disease	Meningioma	MLLT10 SUFU	1.49e-03	19	89	2	C0025286
Disease	epilepsy (implicated_via_orthology)	CDK5R1 KCNT2 TRIO DYNC1H1	1.52e-03	163	89	4	DOID:1826 (implicated_via_orthology)
Disease	end stage renal disease (implicated_via_orthology)	MTOR ACE	1.65e-03	20	89	2	DOID:783 (implicated_via_orthology)
Disease	Lung diseases	A2M SCNN1B ACE	1.71e-03	78	89	3	C0024115
Disease	type 2 diabetes mellitus (is_implicated_in)	MTOR SHBG SREBF1 ACE	1.81e-03	171	89	4	DOID:9352 (is_implicated_in)
Disease	COVID-19 (is_implicated_in)	A2M ACE	1.82e-03	21	89	2	DOID:0080600 (is_implicated_in)
Disease	Arthrogryposis	DYNC1H1 CHRNG	1.82e-03	21	89	2	C0003886
Disease	hypothyroidism (biomarker_via_orthology)	RELN CDK5R1 PLOD1	1.84e-03	80	89	3	DOID:1459 (biomarker_via_orthology)
Disease	complement factor H-like 1 protein measurement	KCNT2 ATP8A2	2.00e-03	22	89	2	EFO_0600092
Disease	hepatocellular carcinoma (is_marker_for)	CENPA MTOR RICTOR SARDH SIX1	2.21e-03	301	89	5	DOID:684 (is_marker_for)
Disease	cortical surface area measurement	GMNC NELL1 RELN ARID1B PCNX3 ATP8A2 SREBF1 USP35 ADGRV1 CALCRL SUFU	2.38e-03	1345	89	11	EFO_0010736
Disease	nephrotic syndrome (implicated_via_orthology)	SCNN1B ACE	2.38e-03	24	89	2	DOID:1184 (implicated_via_orthology)
Disease	Left Ventricular Hypertrophy	MTOR ACE	2.58e-03	25	89	2	C0149721
Disease	Lymphatic Metastasis	MTOR SHBG	2.79e-03	26	89	2	C0024232
Disease	lysophosphatidylethanolamine 16:0 measurement	GRIA1 TNR	2.79e-03	26	89	2	EFO_0010366
Disease	Depressive Symptoms	FASN ACE	2.79e-03	26	89	2	C0086132
Disease	alcohol use disorder (implicated_via_orthology)	ARID1B SREBF1 SMARCA4 CHRNG	2.92e-03	195	89	4	DOID:1574 (implicated_via_orthology)
Disease	lissencephaly (implicated_via_orthology)	CDK5R1 DYNC1H1	3.01e-03	27	89	2	DOID:0050453 (implicated_via_orthology)
Disease	acute kidney failure (implicated_via_orthology)	MTOR ACE	3.01e-03	27	89	2	DOID:3021 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
NVGLLDQRLALQWVQ	ACHE	201	P22303
TLQGSLLWAAGQRQQ	C1orf167	866	Q5SNV9
LLWAAGQRQQGQCLL	C1orf167	871	Q5SNV9
GQRQQGQCLLLWQAR	C1orf167	876	Q5SNV9
VDRSLLLQGWQDQGF	CDK5R1	181	Q15078
LGLDLDAQQARVGQW	ACE	1246	P12821
DAQQARVGQWLLLFL	ACE	1251	P12821
IAQRGGWVAALNLGN	BAK1	171	Q16611
WAFLKLLGANGNANI	AHI1	476	Q8N157
SELLFQQWQRQGLVA	CHRNG	396	P07510
ILRQQGVFGDVQLGW	ADGRV1	1271	Q8WXG9
GYLVGNQQAWLALRQ	CCDC142	716	Q17RM4
LGRVQEFNSGLLHWQ	ARID1B	1876	Q8NFD5
GQILWFRGLNRIQTQ	ATP2B2	1126	Q01814
LRGTQLRNTQWVFGI	ATP8A2	271	Q9NTI2
VQGWALTRQQLQALL	ABCA7	1211	Q8IZY2
KGNRIAQWQSFQLEG	A2M	171	P01023
SIGQLKIWDFRQQGN	NUP43	191	Q8NFH3
GIQRVLFGNNLNFWL	NDST3	266	O95803
RLQLWDIAGQERFGN	RAB32	76	Q13637
DLWNNGNLVQDVFLG	RASA2	256	Q15283
WENAELRGQLLGVTQ	TSPOAP1	401	O95153
NGGYFQQWQLLDRIL	DAAM2	391	Q86T65
IGFIQERAWLRQQGK	POR	541	P16435
LQGLVLGQEFSIRWN	MGAM2	891	Q2M2H8
QRNQLLETRWSFLQG	KRT80	106	Q6KB66
VRGLWAGQQQELVFL	PCNX1	1946	Q96RV3
CVRGLWAGQQQELIF	PCNX2	1781	A6NKB5
WAGQQQELIFLRNRN	PCNX2	1786	A6NKB5
GLWAGQQQELVFLRN	PCNX3	1736	Q9H6A9
GDESFQVGILRQWQL	PCSK7	596	Q16549
NGQLLRERNLLQQSW	DLG5	251	Q8TDM6
ARWNEIFGNNLGALA	DSE	96	Q9UL01
LLGDQGWQNDDRVQV	KCNT2	21	Q6UVM3
RANVEFFNNWGIELL	RICTOR	741	Q6R327
INLWLGQRNQKHGLF	NELL1	186	Q92832
LQANWYRIQGGQVDI	RELN	1616	P78509
FGQWSLGNNKDNRIQ	PLOD1	576	Q02809
GLTILQVNNWFINAR	MEIS3P2	286	A8K0S8
QVLQDWLGLGIYGIQ	OASL	481	Q15646
QGFWENVLLGEVNIR	PIK3C2B	1596	O00750
DSRGQLLWQIFGNQG	MALRD1	966	Q5VYJ5
NGNQLREYQLEGLNW	CHD9	856	Q3L8U1
GVDFNWQAQALLALQ	CENPA	81	P49450
LWGILGAIQAQQQEV	COL6A2	11	P12110
FLNQLQSGVNRWIRE	DYNC1H1	241	Q14204
QAGLRAWTQVLLGQA	DYNC1H1	916	Q14204
IDGFPRNQDNLQGWN	CMPK1	91	P30085
IFQERLLAGQQVWDA	CCDC170	276	Q8IYT3
WGQGIDIQRALQQVR	GRIA1	331	P42261
NQGFLDVVAALRWVQ	CES3	196	Q6UWW8
FGLELAQWLIQRGVQ	FASN	1896	P49327
LQDRGLWAVINNAGV	HSD17B2	156	P37059
GAFVTLQIWLRQAQG	SEC22A	286	Q96IW7
AANNIVWLLSNLGGQ	SCNN1B	511	P51168
VNQSLGLFLAQVRGW	SCARA3	181	Q6AZY7
VQRLEGALWGLQAQA	SCARA5	146	Q6ZMJ2
GNYGLLDQIQALRWL	NLGN2	231	Q8NFZ4
FFNGEVQAILRRNWN	CALCRL	386	Q16602
AIGRIDFLQGNQSAW	NOA1	541	Q8NC60
FLKLGEWQLNLQGIN	MTOR	1751	P42345
QNAQRIGAAALWALI	RTTN	2156	Q86VV8
WALQAYQGQLLQEGA	SFI1	876	A8K8P3
RFSGNFLVNLLGQWA	SEC61A2	311	Q9H9S3
FSQLLRNFGQWLQVE	SYNE3	806	Q6ZMZ3
QLLLDAIEQFGFGNW	TADA2B	76	Q86TJ2
FWAAGLLDNRELQQA	GMNC	41	A6NCL1
GLEWLVSLYNNNLNG	SMARCA4	761	P51532
LWAQGQRLDVDQALN	SHBG	366	P04278
ETQGRFQLLGDIWSN	SIGLEC8	91	Q9NYZ4
LQQGGNLERLGRFLW	SIX1	21	Q15475
GWIQNGGLFIASNRQ	SARDH	146	Q9UL12
QQWLQEGLELQKFGR	SPTBN5	1201	Q9NRC6
LFNRAQLGIADENGW	SHANK1	301	Q9Y566
GDFAQAAQQLWLALR	SREBF1	596	P36956
ERQWSEGQQFLLEQG	MLLT10	721	P55197
LGFLLSWRQDNLNGT	PRY	6	O14603
IGFNNVLNVLNLAVW	SLC7A14	211	Q8TBB6
LRALGLLQQQGQLWT	nan	91	Q6ZTK2
LFRLNNFGLLNSNWG	TRMT61B	171	Q9BVS5
VWVGGQLFQADRALL	KBTBD13	11	C9JR72
QAQQVSGLLAQLWRA	USP35	191	Q9P2H5
LQQQGRFLAGVAWDG	TRIL	456	Q7L0X0
AQQWNGQGILELLRT	SUFU	211	Q9UMX1
GWIVFQRRQNGQTDF	TNR	1176	Q92752
ILSAGQGRCVNQWQL	THOC6	271	Q86W42
QNLKRGNWGNQIEFV	SLC6A9	96	P48067
IGLAQQWDQLYQLGL	SPTA1	2236	P02549
AQALQAAWQRLQVGL	PIGZ	331	Q86VD9
LQQGGNIERLGRFLW	SIX2	21	Q9NPC8
LQQLNNQREWGFLCD	ZBTB1	11	Q9Y2K1
QIGLNGWLRIDDQTV	USP10	756	Q14694
RVSNDNQFLWELIGG	THBS2	296	P35442
IEELLNNFAQQIGAW	XPO6	31	Q96QU8
AQGRELVFALWQQLG	WDR81	896	Q562E7
AALALQEQWLQAGNG	TRIO	3041	O75962
ALNQWALDFEGNLQR	NADSYN1	11	Q6IA69