Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	glucosyltransferase activity	ALG5 UGCG PLOD1	6.32e-05	22	71	3	GO:0046527
GeneOntologyMolecularFunction	RNA strand annealing activity	FXR1 FMR1	1.24e-04	5	71	2	GO:0033592
GeneOntologyBiologicalProcess	regulation of translation at presynapse, modulating synaptic transmission	FXR1 FMR1 FXR2	3.74e-08	3	70	3	GO:0099577
GeneOntologyBiologicalProcess	regulation of translation at presynapse	FXR1 FMR1 FXR2	3.74e-08	3	70	3	GO:0140244
GeneOntologyBiologicalProcess	regulation of translation at synapse, modulating synaptic transmission	FXR1 FMR1 FXR2	3.10e-06	9	70	3	GO:0099547
GeneOntologyBiologicalProcess	positive regulation of long-term neuronal synaptic plasticity	FXR1 FMR1 FXR2	6.06e-06	11	70	3	GO:0048170
GeneOntologyBiologicalProcess	regulation of translation at synapse	FXR1 FMR1 FXR2	1.04e-05	13	70	3	GO:0140243
GeneOntologyBiologicalProcess	Rab protein signal transduction	RAB12 RAB21 RAB4A	4.77e-05	21	70	3	GO:0032482
GeneOntologyBiologicalProcess	regulation of long-term synaptic potentiation	FXR1 FMR1 EIF2AK4 HNRNPK	7.93e-05	67	70	4	GO:1900271
GeneOntologyBiologicalProcess	positive regulation of receptor-mediated endocytosis	FMR1 PARD3 RAB21 HNRNPK	7.93e-05	67	70	4	GO:0048260
GeneOntologyBiologicalProcess	negative regulation of CREB transcription factor activity	SIK1 EIF2AK4	1.13e-04	5	70	2	GO:0032792
GeneOntologyBiologicalProcess	regulation of neuronal synaptic plasticity	FXR1 FMR1 FXR2 KMT2A	1.83e-04	83	70	4	GO:0048168
GeneOntologyBiologicalProcess	peripheral nervous system axon ensheathment	AKT2 PARD3 ADAM22	1.90e-04	33	70	3	GO:0032292
GeneOntologyBiologicalProcess	myelination in peripheral nervous system	AKT2 PARD3 ADAM22	1.90e-04	33	70	3	GO:0022011
GeneOntologyBiologicalProcess	positive regulation of long-term synaptic potentiation	FMR1 EIF2AK4 HNRNPK	2.08e-04	34	70	3	GO:1900273
GeneOntologyBiologicalProcess	regulation of long-term neuronal synaptic plasticity	FXR1 FMR1 FXR2	3.38e-04	40	70	3	GO:0048169
Domain	FXMRP1_C_core	FXR1 FMR1 FXR2	4.62e-08	3	68	3	IPR022034
Domain	Agenet-like_dom	FXR1 FMR1 FXR2	4.62e-08	3	68	3	IPR008395
Domain	Agenet	FXR1 FMR1 FXR2	4.62e-08	3	68	3	PF05641
Domain	FXMRP1_C_core	FXR1 FMR1 FXR2	4.62e-08	3	68	3	PF12235
Domain	AGENET_LIKE	FXR1 FMR1 FXR2	4.62e-08	3	68	3	PS51641
Domain	KH_1	FXR1 FMR1 FXR2 HNRNPK	1.08e-05	38	68	4	PF00013
Domain	-	FXR1 FMR1 FXR2 HNRNPK	1.20e-05	39	68	4	3.30.1370.10
Domain	FXR_C1	FXR1 FXR2	1.31e-05	2	68	2	PF16096
Domain	FXR_C1	FXR1 FXR2	1.31e-05	2	68	2	IPR032172
Domain	KH	FXR1 FMR1 FXR2 HNRNPK	1.33e-05	40	68	4	SM00322
Domain	KH_dom	FXR1 FMR1 FXR2 HNRNPK	1.33e-05	40	68	4	IPR004087
Domain	KH_TYPE_1	FXR1 FMR1 FXR2 HNRNPK	1.62e-05	42	68	4	PS50084
Domain	KH_dom_type_1	FXR1 FMR1 FXR2 HNRNPK	1.95e-05	44	68	4	IPR004088
Domain	PHD	PHF19 KDM5A ASH1L KMT2A	1.61e-04	75	68	4	PF00628
Domain	Gasdermin	GSDME GSDMC	1.94e-04	6	68	2	PF04598
Domain	Znf_PHD-finger	PHF19 KDM5A ASH1L KMT2A	1.97e-04	79	68	4	IPR019787
Domain	PHD	PHF19 KDM5A ASH1L KMT2A	3.11e-04	89	68	4	SM00249
Domain	Znf_PHD	PHF19 KDM5A ASH1L KMT2A	3.38e-04	91	68	4	IPR001965
Domain	VIT	PARP4 ITIH3	3.61e-04	8	68	2	PF08487
Domain	VIT	PARP4 ITIH3	3.61e-04	8	68	2	SM00609
Domain	Gasdermin	GSDME GSDMC	3.61e-04	8	68	2	IPR007677
Domain	ZF_PHD_2	PHF19 KDM5A ASH1L KMT2A	3.99e-04	95	68	4	PS50016
Domain	ZF_PHD_1	PHF19 KDM5A ASH1L KMT2A	4.15e-04	96	68	4	PS01359
Domain	SET	ASH1L KMT2A SMYD5	4.46e-04	41	68	3	PF00856
Domain	VIT	PARP4 ITIH3	5.77e-04	10	68	2	PS51468
Domain	VIT	PARP4 ITIH3	5.77e-04	10	68	2	IPR013694
Domain	SET	ASH1L KMT2A SMYD5	6.26e-04	46	68	3	SM00317
Domain	SET_dom	ASH1L KMT2A SMYD5	8.00e-04	50	68	3	IPR001214
Domain	SET	ASH1L KMT2A SMYD5	8.00e-04	50	68	3	PS50280
Domain	VWA	PARP4 VIT ITIH3	1.11e-03	56	68	3	PF00092
Domain	Post-SET_dom	ASH1L KMT2A	1.52e-03	16	68	2	IPR003616
Domain	PostSET	ASH1L KMT2A	1.52e-03	16	68	2	SM00508
Domain	POST_SET	ASH1L KMT2A	1.52e-03	16	68	2	PS50868
Domain	Poly(ADP-ribose)pol_cat_dom	PARP6 PARP4	1.71e-03	17	68	2	IPR012317
Domain	PARP_CATALYTIC	PARP6 PARP4	1.71e-03	17	68	2	PS51059
Domain	PARP	PARP6 PARP4	1.71e-03	17	68	2	PF00644
Domain	-	PARP6 PARP4	1.71e-03	17	68	2	3.90.228.10
Domain	Zinc_finger_PHD-type_CS	PHF19 KDM5A ASH1L	1.72e-03	65	68	3	IPR019786
Domain	Znf_FYVE_PHD	PHF19 KDM5A ASH1L KMT2A	2.03e-03	147	68	4	IPR011011
Domain	Ca/CaM-dep_Ca-dep_prot_Kinase	MARK4 TSSK2 SIK1	2.04e-03	69	68	3	IPR020636
Domain	RAB	RAB12 RAB21 RAB4A	2.39e-03	73	68	3	PS51419
Domain	-	PARP4 VIT ITIH3	2.49e-03	74	68	3	3.40.50.410
Domain	Protein_kinase_ATP_BS	MARK4 TSSK2 SIK1 AKT2 ROS1 EIF2AK4	2.55e-03	379	68	6	IPR017441
Domain	BRCT	PARP4 SLF1	2.88e-03	22	68	2	SM00292
Domain	HAD-like_dom	ATP7A ATP2B3 PMM2	3.00e-03	79	68	3	IPR023214
Domain	-	PARP4 SLF1	3.15e-03	23	68	2	3.40.50.10190
Domain	VWFA	PARP4 VIT ITIH3	3.33e-03	82	68	3	PS50234
Domain	WGR_domain	PARP6 PARP4	3.42e-03	24	68	2	IPR008893
Domain	NA-bd_OB-fold	FXR1 RPS11 MCM4	3.44e-03	83	68	3	IPR012340
Domain	VWA	PARP4 VIT ITIH3	3.56e-03	84	68	3	SM00327
Domain	BRCT	PARP4 SLF1	4.01e-03	26	68	2	PS50172
Domain	Nucleotide-diphossugar_trans	ALG5 UGCG PLOD1	4.06e-03	88	68	3	IPR029044
Domain	AT_hook	ASH1L KMT2A	4.32e-03	27	68	2	SM00384
Domain	AT_hook_DNA-bd_motif	ASH1L KMT2A	4.32e-03	27	68	2	IPR017956
Domain	BRCT_dom	PARP4 SLF1	4.64e-03	28	68	2	IPR001357
Domain	Glycos_transf_2	ALG5 UGCG	5.32e-03	30	68	2	PF00535
Domain	Glyco_trans_2-like	ALG5 UGCG	5.32e-03	30	68	2	IPR001173
Domain	UBA	MARK4 SIK1	5.32e-03	30	68	2	SM00165
Domain	-	RAB12 MCM4 DDX51 MSH3 COASY RAB21 DNA2 RAB4A	5.56e-03	746	68	8	3.40.50.300
Domain	VWF_A	PARP4 VIT ITIH3	5.64e-03	99	68	3	IPR002035
Pubmed	Fragile X-related proteins regulate mammalian circadian behavioral rhythms.	FXR1 FMR1 FXR2	8.15e-09	3	71	3	18589395
Pubmed	Spatial control of nucleoporin condensation by fragile X-related proteins.	FXR1 FMR1 FXR2	8.15e-09	3	71	3	32706158
Pubmed	Trapping of messenger RNA by Fragile X Mental Retardation protein into cytoplasmic granules induces translation repression.	FXR1 FMR1 FXR2	8.15e-09	3	71	3	12417522
Pubmed	The fragile X mental retardation syndrome protein interacts with novel homologs FXR1 and FXR2.	FXR1 FMR1 FXR2	8.15e-09	3	71	3	7489725
Pubmed	Specific sequences in the fragile X syndrome protein FMR1 and the FXR proteins mediate their binding to 60S ribosomal subunits and the interactions among them.	FXR1 FMR1 FXR2	8.15e-09	3	71	3	8668200
Pubmed	Sub-synaptic, multiplexed analysis of proteins reveals Fragile X related protein 2 is mislocalized in Fmr1 KO synapses.	FXR1 FMR1 FXR2	8.15e-09	3	71	3	27770568
Pubmed	Discrimination of common and unique RNA-binding activities among Fragile X mental retardation protein paralogs.	FXR1 FMR1 FXR2	8.15e-09	3	71	3	19487368
Pubmed	Fragile X mental retardation protein has a unique, evolutionarily conserved neuronal function not shared with FXR1P or FXR2P.	FXR1 FMR1 FXR2	8.15e-09	3	71	3	20442204
Pubmed	LLPS of FXR proteins drives replication organelle clustering for β-coronaviral proliferation.	FXR1 FMR1 FXR2	8.15e-09	3	71	3	38587486
Pubmed	The fragile X-related proteins FXR1P and FXR2P contain a functional nucleolar-targeting signal equivalent to the HIV-1 regulatory proteins.	FXR1 FMR1 FXR2	8.15e-09	3	71	3	10888599
Pubmed	Evidence that fragile X mental retardation protein is a negative regulator of translation.	FXR1 FMR1 FXR2	8.15e-09	3	71	3	11157796
Pubmed	Fragile X-related protein family: a double-edged sword in neurodevelopmental disorders and cancer.	FXR1 FMR1 FXR2	8.15e-09	3	71	3	32878499
Pubmed	Accumulated common variants in the broader fragile X gene family modulate autistic phenotypes.	FXR1 FMR1 FXR2	8.15e-09	3	71	3	26612855
Pubmed	Differential expression of FMR1, FXR1 and FXR2 proteins in human brain and testis.	FXR1 FMR1 FXR2	8.15e-09	3	71	3	9259278
Pubmed	Isolation of an FMRP-associated messenger ribonucleoprotein particle and identification of nucleolin and the fragile X-related proteins as components of the complex.	FXR1 FMR1 FXR2	3.26e-08	4	71	3	10567518
Pubmed	The nuclear microspherule protein 58 is a novel RNA-binding protein that interacts with fragile X mental retardation protein in polyribosomal mRNPs from neurons.	FXR1 FMR1 FXR2	3.26e-08	4	71	3	16571602
Pubmed	Tdrd3 is a novel stress granule-associated protein interacting with the Fragile-X syndrome protein FMRP.	FXR1 FMR1 FXR2	3.26e-08	4	71	3	18664458
Pubmed	A novel RNA-binding nuclear protein that interacts with the fragile X mental retardation (FMR1) protein.	FXR1 FMR1 FXR2	3.26e-08	4	71	3	10556305
Pubmed	Defining the membrane proteome of NK cells.	PARP4 DNAJC13 FXR1 ATP7A FMR1 FXR2 ALG5 RPS11 MCM4 DDX51 MSH3 FKBP8 PLEK HNRNPK	8.67e-08	1168	71	14	19946888
Pubmed	A highly conserved protein family interacting with the fragile X mental retardation protein (FMRP) and displaying selective interactions with FMRP-related proteins FXR1P and FXR2P.	FXR1 FMR1 FXR2	1.62e-07	6	71	3	11438699
Pubmed	C1orf106 is a colitis risk gene that regulates stability of epithelial adherens junctions.	FXR1 FMR1 FXR2 RPS11	2.70e-07	27	71	4	29420262
Pubmed	Identification of a long non-coding RNA-associated RNP complex regulating metastasis at the translational step.	FXR1 FXR2 HNRNPK	4.53e-07	8	71	3	23974796
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	FXR1 FMR1 RRP1B KDM5A FXR2 KMT2A ROS1 EIF2AK4 PARD3 RAB21 PLOD1 ITIH3 HP1BP3 TFPI	6.01e-07	1371	71	14	36244648
Pubmed	Fragile X related protein 1 clusters with ribosomes and messenger RNAs at a subset of dendritic spines in the mouse hippocampus.	FXR1 FMR1 FXR2	1.33e-06	11	71	3	22022532
Pubmed	FXR1P but not FMRP regulates the levels of mammalian brain-specific microRNA-9 and microRNA-124.	FXR1 FMR1 FXR2	1.33e-06	11	71	3	21957233
Pubmed	Fbxo4-mediated degradation of Fxr1 suppresses tumorigenesis in head and neck squamous cell carcinoma.	FXR1 FMR1 FXR2	1.33e-06	11	71	3	29142209
Pubmed	Dynamic patterns of histone H3 lysine 4 methyltransferases and demethylases during mouse preimplantation development.	KDM5A ASH1L KMT2A	2.30e-06	13	71	3	24619213
Pubmed	CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.	PARP4 DNAJC13 RRP1B FXR2 MCM4 FKBP8 RAB21 DNA2 PLOD1	3.98e-06	606	71	9	36538041
Pubmed	The fragile X syndrome protein FMRP associates with BC1 RNA and regulates the translation of specific mRNAs at synapses.	FXR1 FMR1	4.11e-06	2	71	2	12581522
Pubmed	The RNA-binding protein fragile X-related 1 regulates somite formation in Xenopus laevis.	FXR1 FMR1	4.11e-06	2	71	2	16000371
Pubmed	Comparative genomic sequence analysis of the FXR gene family: FMR1, FXR1, and FXR2.	FXR1 FXR2	4.11e-06	2	71	2	11735223
Pubmed	Highly conserved 3' UTR and expression pattern of FXR1 points to a divergent gene regulation of FXR1 and FMR1.	FXR1 FMR1	4.11e-06	2	71	2	8634689
Pubmed	Deficient Sleep in Mouse Models of Fragile X Syndrome.	FMR1 FXR2	4.11e-06	2	71	2	28919851
Pubmed	On the aggregation properties of FMRP--a link with the FXTAS syndrome?	FMR1 FXR2	4.11e-06	2	71	2	21446998
Pubmed	Mutsβ generates both expansions and contractions in a mouse model of the Fragile X-associated disorders.	FMR1 MSH3	4.11e-06	2	71	2	26420841
Pubmed	Dicer-derived microRNAs are utilized by the fragile X mental retardation protein for assembly on target RNAs.	FXR1 FMR1	4.11e-06	2	71	2	17057366
Pubmed	Altered hippocampal synaptic plasticity in the FMR1 gene family knockout mouse models.	FMR1 FXR2	4.11e-06	2	71	2	19244359
Pubmed	The FXG: a presynaptic fragile X granule expressed in a subset of developing brain circuits.	FMR1 FXR2	4.11e-06	2	71	2	19193898
Pubmed	FXR1, an autosomal homolog of the fragile X mental retardation gene.	FXR1 FMR1	4.11e-06	2	71	2	7781595
Pubmed	Structural studies of the tandem Tudor domains of fragile X mental retardation related proteins FXR1 and FXR2.	FXR1 FXR2	4.11e-06	2	71	2	21072162
Pubmed	Oligomerization properties of fragile-X mental-retardation protein (FMRP) and the fragile-X-related proteins FXR1P and FXR2P.	FXR1 FMR1	4.11e-06	2	71	2	10527928
Pubmed	Different targets for the fragile X-related proteins revealed by their distinct nuclear localizations.	FXR1 FXR2	4.11e-06	2	71	2	10196376
Pubmed	Exaggerated behavioral phenotypes in Fmr1/Fxr2 double knockout mice reveal a functional genetic interaction between Fragile X-related proteins.	FMR1 FXR2	4.11e-06	2	71	2	16675531
Pubmed	The Fragile X proteins Fmrp and Fxr2p cooperate to regulate glucose metabolism in mice.	FMR1 FXR2	4.11e-06	2	71	2	25552647
Pubmed	WWP2 ubiquitylates RNA polymerase II for DNA-PK-dependent transcription arrest and repair at DNA breaks.	DNAJC13 FXR1 FMR1 RRP1B FXR2 RPS11 PLOD1 HNRNPK HP1BP3	4.48e-06	615	71	9	31048545
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	FXR1 FMR1 RRP1B FXR2 KMT2A MCM4 DDX51 PLOD1 HP1BP3	7.25e-06	653	71	9	22586326
Pubmed	The association of UBAP2L and G3BP1 mediated by small nucleolar RNA is essential for stress granule formation.	FXR1 FMR1 FXR2	1.06e-05	21	71	3	37059803
Pubmed	Transport kinetics of FMRP containing the I304N mutation of severe fragile X syndrome in neurites of living rat PC12 cells.	FXR1 FMR1	1.23e-05	3	71	2	15380484
Pubmed	Akt2 deficiency promotes cardiac induction of Rab4a and myocardial β-adrenergic hypersensitivity.	AKT2 RAB4A	1.23e-05	3	71	2	20728450
Pubmed	miR-142-3p down-regulation contributes to thyroid follicular tumorigenesis by targeting ASH1L and MLL1.	ASH1L KMT2A	1.23e-05	3	71	2	25238203
Pubmed	Fragile X Proteins FMRP and FXR2P Control Synaptic GluA1 Expression and Neuronal Maturation via Distinct Mechanisms.	FMR1 FXR2	1.23e-05	3	71	2	26051932
Pubmed	FXR1 regulates transcription and is required for growth of human cancer cells with TP53/FXR2 homozygous deletion.	FXR1 FXR2	1.23e-05	3	71	2	28767039
Pubmed	Differential regulation of Akt/protein kinase B isoforms during cell cycle progression.	AKT2 PARD3	1.23e-05	3	71	2	19166849
Pubmed	FXR2P Exerts a Positive Translational Control and Is Required for the Activity-Dependent Increase of PSD95 Expression.	FMR1 FXR2	1.23e-05	3	71	2	26109663
Pubmed	FMRP, FXR1 protein and Dlg4 mRNA, which are associated with fragile X syndrome, are involved in the ubiquitin-proteasome system.	FXR1 FMR1	1.23e-05	3	71	2	36732356
Pubmed	BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.	FXR1 RRP1B KDM5A FXR2 ALG5 RPS11 KMT2A MCM4 RAB21 PLOD1 HNRNPK HP1BP3	1.35e-05	1318	71	12	30463901
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	SPAM1 FXR1 FMR1 KDM5A FXR2 MARK4 ASH1L QTRT2 FKBP8 PARD3 DNA2	1.55e-05	1116	71	11	31753913
Pubmed	Fragile X related protein 1 (FXR1P) regulates proliferation of adult neural stem cells.	FXR1 FXR2	2.46e-05	4	71	2	28204491
Pubmed	Tumor suppressor mediated ubiquitylation of hnRNPK is a barrier to oncogenic translation.	FXR1 HNRNPK	2.46e-05	4	71	2	36329064
Pubmed	KDM5A noncanonically binds antagonists MLL1/2 to mediate gene regulation and promotes epithelial to mesenchymal transition.	KDM5A KMT2A	2.46e-05	4	71	2	37722486
Pubmed	Gasdermin D is the only Gasdermin that provides protection against acute Salmonella gut infection in mice.	GSDME GSDMC	2.46e-05	4	71	2	37988464
Pubmed	The nuclear protein PH5P of the inter-alpha-inhibitor superfamily: a missing link between poly(ADP-ribose)polymerase and the inter-alpha-inhibitor family and a novel actor of DNA repair?	PARP4 ITIH3	2.46e-05	4	71	2	10100603
Pubmed	Loss of TRIM31 promotes breast cancer progression through regulating K48- and K63-linked ubiquitination of p53.	DNAJC13 FXR1 FMR1 RRP1B FXR2 RPS11 HNRNPK	2.47e-05	421	71	7	34650049
Pubmed	Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant.	FXR1 FMR1 FXR2 MARK4 FKBP8 PARD3 ADAM22	2.83e-05	430	71	7	32581705
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	DNAJC13 ATP7A RPS11 FKBP8 PARD3 RAB21 HNRNPK HP1BP3 SH3BP4	2.86e-05	777	71	9	35844135
Pubmed	SILAC-based proteomics of human primary endothelial cell morphogenesis unveils tumor angiogenic markers.	FXR1 FMR1 FXR2 RPS11 HNRNPK	2.87e-05	173	71	5	23979707
Pubmed	FBW7 suppresses ovarian cancer development by targeting the N6-methyladenosine binding protein YTHDF2.	DNAJC13 FXR1 FMR1 RRP1B RPS11 KMT2A EIF2AK4 HP1BP3	3.10e-05	601	71	8	33658012
Pubmed	CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.	FMR1 RRP1B FXR2 RPS11 KMT2A DDX51 HNRNPK HP1BP3	3.25e-05	605	71	8	28977666
Pubmed	Targeted and Interactome Proteomics Revealed the Role of PHD2 in Regulating BRD4 Proline Hydroxylation.	FXR1 FMR1 RRP1B FXR2 RPS11 HNRNPK HP1BP3	3.32e-05	441	71	7	31239290
Pubmed	EZH2 interacts with HP1BP3 to epigenetically activate WNT7B that promotes temozolomide resistance in glioblastoma.	DNAJC13 FXR1 RPS11 MCM4 FKBP8 RAB21 PLOD1 HNRNPK HP1BP3	3.70e-05	803	71	9	36517590
Pubmed	Large-scale proteomics and phosphoproteomics of urinary exosomes.	SNF8 PARP4 DNAJC13 SLC12A1 RPS11 COASY SAT2 RAB21 PLOD1 SH3BP4	3.98e-05	1016	71	10	19056867
Pubmed	Novel FMRP interaction networks linked to cellular stress.	FXR1 FMR1	4.09e-05	5	71	2	32525608
Pubmed	SARS-CoV-2 nucleocapsid protein binds host mRNAs and attenuates stress granules to impair host stress response.	FXR1 FMR1 RRP1B FXR2 RPS11 COASY HNRNPK	4.52e-05	463	71	7	34901782
Pubmed	A protein interaction landscape of breast cancer.	FXR1 FMR1 PHF19 FXR2 AKT2 MSH3 PLOD1 HP1BP3	4.52e-05	634	71	8	34591612
Pubmed	Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.	CRYBG2 FXR1 FMR1 PHF19 KMT2A MCM4 DNA2	4.90e-05	469	71	7	27634302
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	PARP4 FMR1 KMT2A EIF2AK4 FKBP8 DNA2 HP1BP3 SH3BP4	5.39e-05	650	71	8	38777146
Pubmed	Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.	DNAJC13 FXR1 FMR1 RRP1B FXR2 RPS11 KMT2A DDX51 HP1BP3	5.58e-05	847	71	9	35850772
Pubmed	Identification of Human Neuronal Protein Complexes Reveals Biochemical Activities and Convergent Mechanisms of Action in Autism Spectrum Disorders.	FXR1 FMR1 FXR2 MCM4	5.61e-05	101	71	4	26949739
Pubmed	SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation-Phosphorylation Cross-talk.	FXR1 FMR1 RRP1B FXR2 RPS11 PLOD1 HNRNPK HP1BP3	5.68e-05	655	71	8	35819319
Pubmed	ZZW-115-dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents.	FXR1 FMR1 RRP1B FXR2 MSH3 PLOD1 HP1BP3 TFPI	5.99e-05	660	71	8	32780723
Pubmed	Ash1l controls quiescence and self-renewal potential in hematopoietic stem cells.	ASH1L KMT2A	6.13e-05	6	71	2	25866973
Pubmed	Wdr1-mediated cell shape dynamics and cortical tension are essential for epidermal planar cell polarity.	CELSR1 PARD3	6.13e-05	6	71	2	25915128
Pubmed	Akt2 (Protein Kinase B Beta) Stabilizes ATP7A, a Copper Transporter for Extracellular Superoxide Dismutase, in Vascular Smooth Muscle: Novel Mechanism to Limit Endothelial Dysfunction in Type 2 Diabetes Mellitus.	ATP7A AKT2	6.13e-05	6	71	2	29301787
Pubmed	Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression.	FXR1 FMR1 RRP1B FXR2 DDX51 HP1BP3	6.15e-05	332	71	6	25693804
Pubmed	Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia.	RRP1B KMT2A MCM4 HP1BP3	6.28e-05	104	71	4	26167872
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	FXR1 KDM5A MARK4 TSSK2 KMT2A SIK1 PARD3 RAB21 SH3BP4	6.32e-05	861	71	9	36931259
Pubmed	A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.	PARP4 GSDME FMR1 KDM5A BTBD1 PARD3 HNRNPK	7.05e-05	497	71	7	23414517
Pubmed	Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1.	PARP4 RRP1B TTLL1	8.22e-05	41	71	3	8724849
Pubmed	KAP1 facilitates reinstatement of heterochromatin after DNA replication.	FXR1 ALG5 RPS11 MCM4 MSH3 RAB21 HNRNPK PMM2	9.38e-05	704	71	8	29955894
Pubmed	TRIM65 regulates microRNA activity by ubiquitination of TNRC6.	FXR1 FMR1 RRP1B FXR2 DNA2 HP1BP3	1.02e-04	364	71	6	24778252
Pubmed	RNA-binding proteins with basic-acidic dipeptide (BAD) domains self-assemble and aggregate in Alzheimer's disease.	FXR1 FMR1 RRP1B FXR2 RPS11 PLOD1 HNRNPK HP1BP3	1.02e-04	713	71	8	29802200
Pubmed	Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.	RRP1B RPS11 ASH1L KMT2A MSH3 HNRNPK HP1BP3	1.09e-04	533	71	7	30554943
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	PARP4 DNAJC13 FXR1 FMR1 KDM5A FXR2 PLOD1 HNRNPK	1.14e-04	724	71	8	36232890
Pubmed	Skirting the pitfalls: a clear-cut nomenclature for H3K4 methyltransferases.	ASH1L KMT2A	1.14e-04	8	71	2	23130995
Pubmed	Plakophilins 1 and 3 bind to FXR1 and thereby influence the mRNA stability of desmosomal proteins.	FXR1 FMR1	1.14e-04	8	71	2	25225333
Pubmed	Tissue and developmental regulation of fragile X mental retardation 1 exon 12 and 15 isoforms.	FMR1 UGCG	1.14e-04	8	71	2	19362146
Pubmed	Using brain cell-type-specific protein interactomes to interpret neurodevelopmental genetic signals in schizophrenia.	FXR1 FMR1 BTBD1	1.16e-04	46	71	3	37207277
Pubmed	TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1.	FXR1 FMR1 RRP1B FXR2 RPS11 MCM4 DDX51 HNRNPK HP1BP3	1.32e-04	949	71	9	36574265
Pubmed	Structural basis of family-wide Rab GTPase recognition by rabenosyn-5.	RAB21 RAB4A	1.47e-04	9	71	2	16034420
Pubmed	SARS-CoV-2 N Protein Antagonizes Stress Granule Assembly and IFN Production by Interacting with G3BPs to Facilitate Viral Replication.	FXR1 FMR1 RRP1B HNRNPK HP1BP3	1.48e-04	245	71	5	35652658
GeneFamily	PHD finger proteins	PHF19 KDM5A ASH1L KMT2A	8.69e-05	90	47	4	88
GeneFamily	RAB, member RAS oncogene GTPases	RAB12 RAB21 RAB4A	6.42e-04	65	47	3	388
GeneFamily	Zinc fingers\|Zinc fingers PARP-type\|Poly(ADP-ribose) polymerases	PARP6 PARP4	8.77e-04	17	47	2	684
GeneFamily	Zinc fingers C2H2-type\|Lysine methyltransferases\|PR/SET domain family	ASH1L KMT2A	3.52e-03	34	47	2	487
Coexpression	GSE7348_LPS_VS_TOLERIZED_AND_LPS_STIM_MACROPHAGE_UP	ATP7A RRP1B NBEAL1 ALG5 QTRT2 DDX51 EIF2AK4	6.11e-07	181	71	7	M6849
Coexpression	GOLDRATH_EFF_VS_MEMORY_CD8_TCELL_DN	RRP1B SURF2 ASH1L DDX51 EIF2AK4 ADAM22	1.74e-05	200	71	6	M3044
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SEMA4D PARP4 CELSR1 DNAH17 AKT2 PARD3	4.80e-07	183	71	6	92fbd83a9d13ee91065cbd479fb298f1fd564568
Drug	4-aminohexanoic Acid	FXR1 FMR1 FXR2 SPIC	2.57e-07	18	71	4	CID000138490
Drug	VAI2	FXR1 FMR1 FXR2 HNRNPK TFPI PMM2	5.86e-07	97	71	6	CID003474204
Drug	ICI 182,780; Up 200; 1uM; HL60; HT_HG-U133A	TEX261 GSDME PDE8B TTLL1 FKBP8 PARD3 ADAM22	2.45e-06	194	71	7	1146_UP
Drug	Phenethicillin potassium salt [132-93-4]; Down 200; 10uM; MCF7; HT_HG-U133A	PDE8B DNAH17 KMT2A AKT2 FKBP8 ADAM22 TFPI	2.72e-06	197	71	7	6105_DN
Drug	GW8510; Up 200; 10uM; PC3; HT_HG-U133A	GABRR2 SPAM1 PDE8B UGCG SIK1 FKBP8	2.53e-05	186	71	6	7067_UP
Drug	0173570-0000 [211245-44-2]; Down 200; 10uM; MCF7; HT_HG-U133A	TEX261 MARK4 UGCG AKT2 ADAM22 TFPI	3.30e-05	195	71	6	4712_DN
Drug	Verapamyl hydrochloride [152-11-4]; Up 200; 8.2uM; PC3; HG-U133A	DNAJC13 FMR1 UGCG SIK1 MSH3 TFPI	3.30e-05	195	71	6	1927_UP
Drug	Fluspirilen [1841-19-6]; Down 200; 8.4uM; PC3; HT_HG-U133A	TEX261 SEMA4D RRP1B MARK4 TSSK2 TTLL1	3.30e-05	195	71	6	6662_DN
Drug	novobiocin sodium, USP; Down 200; 100uM; SKMEL5; HG-U133A	ASH1L MCM4 MSH3 FKBP8 PARD3 HP1BP3	3.30e-05	195	71	6	632_DN
Drug	Progesterone [57-83-0]; Up 200; 12.8uM; PC3; HT_HG-U133A	SPAM1 PDE8B PLCH2 KMT2A ATP2B3 ADAM22	3.39e-05	196	71	6	6646_UP
Drug	Riluzole hydrochloride; Up 200; 14.8uM; HL60; HT_HG-U133A	TEX261 GSDME KDM5A MARK4 KMT2A ADAM22	3.49e-05	197	71	6	2334_UP
Drug	Tocopherol (R,S) [10191-41-0]; Up 200; 9.2uM; HL60; HT_HG-U133A	DNAJC13 GSDME RRP1B UGCG TTLL1 FKBP8	3.59e-05	198	71	6	1320_UP
Drug	Sulfanilamide [63-74-1]; Up 200; 23.2uM; MCF7; HT_HG-U133A	GABRR2 SPAM1 KMT2A AKT2 FKBP8 ADAM22	3.69e-05	199	71	6	3449_UP
Drug	Cefsulodin sodium salt [52152-93-9]; Up 200; 7.2uM; PC3; HT_HG-U133A	TEX261 GABRR2 FXR2 PLCH2 AKT2 TTLL1	3.69e-05	199	71	6	4067_UP
Drug	(-) -Levobunolol hydrochloride [27912-14-7]; Down 200; 12.2uM; PC3; HT_HG-U133A	SPAM1 PDE8B MARK4 TTLL1 ATP2B3 ADAM22	3.69e-05	199	71	6	4016_DN
Drug	Pralidoxime chloride [51-15-0]; Up 200; 23.2uM; PC3; HT_HG-U133A	PARP6 CRYBG2 FXR2 UGCG FKBP8 ADAM22	3.80e-05	200	71	6	6283_UP
Drug	AC1NB8R3	FXR1 FMR1 FXR2 KMT2A HNRNPK TFPI	5.39e-05	213	71	6	CID004489307
Drug	trimethoprim-sulfamethoxazole	FXR1 FMR1 FXR2 HNRNPK	5.41e-05	66	71	4	CID000358641
Disease	malignant pleural mesothelioma (implicated_via_orthology)	FXR1 FMR1 FXR2	1.22e-08	3	69	3	DOID:7474 (implicated_via_orthology)
Disease	fragile X syndrome (implicated_via_orthology)	FXR1 FMR1 FXR2	1.22e-08	3	69	3	DOID:14261 (implicated_via_orthology)
Disease	autism spectrum disorder (implicated_via_orthology)	FXR1 FMR1 KDM5A FXR2 ASH1L	2.93e-05	152	69	5	DOID:0060041 (implicated_via_orthology)
Disease	diamine acetyltransferase 2 measurement	FXR2 SAT2	8.03e-05	6	69	2	EFO_0802465
Disease	pneumococcal meningitis	CELSR1 ROS1	1.50e-04	8	69	2	EFO_1001114
Disease	NEURAL TUBE DEFECTS, SUSCEPTIBILITY TO	CELSR1 PARD3	1.50e-04	8	69	2	C3891448
Disease	HDL cholesterol change measurement, response to simvastatin, response to fenofibrate	CELSR1 MSH3	1.50e-04	8	69	2	EFO_0007805, GO_1901557, GO_1903491
Disease	blood nickel measurement	SLC12A1 UGCG PLEK GSDMC	1.83e-04	120	69	4	EFO_0007583
Disease	developmental disorder of mental health (implicated_via_orthology)	GABRR2 ASH1L PARD3	2.09e-04	49	69	3	DOID:0060037 (implicated_via_orthology)
Disease	congenital disorder of glycosylation type I (implicated_via_orthology)	ALG5 PMM2	5.55e-04	15	69	2	DOID:0050570 (implicated_via_orthology)
Disease	pentachlorophenol measurement	UGCG PLEK GSDMC	6.77e-04	73	69	3	EFO_0022071
Disease	parathion measurement	UGCG PLEK GSDMC	6.77e-04	73	69	3	EFO_0022070
Disease	potassium chromate measurement	UGCG PLEK GSDMC	6.77e-04	73	69	3	EFO_0022072
Disease	mercuric chloride measurement	UGCG PLEK GSDMC	6.77e-04	73	69	3	EFO_0022068
Disease	heptachlor epoxide measurement	UGCG PLEK GSDMC	6.77e-04	73	69	3	EFO_0022067
Disease	methoxychlor measurement	UGCG PLEK GSDMC	6.77e-04	73	69	3	EFO_0022069
Disease	4,6-dinitro-o-cresol measurement	UGCG PLEK GSDMC	6.77e-04	73	69	3	EFO_0022053
Disease	2,4,5-trichlorophenol measurement	UGCG PLEK GSDMC	6.77e-04	73	69	3	EFO_0022052
Disease	azinphos methyl measurement	UGCG PLEK GSDMC	6.77e-04	73	69	3	EFO_0022055
Disease	aldrin measurement	UGCG PLEK GSDMC	6.77e-04	73	69	3	EFO_0022054
Disease	dicofol measurement	UGCG PLEK GSDMC	6.77e-04	73	69	3	EFO_0022060
Disease	disulfoton measurement	UGCG PLEK GSDMC	6.77e-04	73	69	3	EFO_0022062
Disease	dieldrin measurement	UGCG PLEK GSDMC	6.77e-04	73	69	3	EFO_0022061
Disease	endrin measurement	UGCG PLEK GSDMC	6.77e-04	73	69	3	EFO_0022064
Disease	endosulfan measurement	UGCG PLEK GSDMC	6.77e-04	73	69	3	EFO_0022063
Disease	heptachlor measurement	UGCG PLEK GSDMC	6.77e-04	73	69	3	EFO_0022066
Disease	ethion measurement	UGCG PLEK GSDMC	6.77e-04	73	69	3	EFO_0022065
Disease	chlorpyrifos measurement	UGCG PLEK GSDMC	6.77e-04	73	69	3	EFO_0022057
Disease	cadmium chloride measurement	UGCG PLEK GSDMC	6.77e-04	73	69	3	EFO_0022056
Disease	diazinon measurement	UGCG PLEK GSDMC	6.77e-04	73	69	3	EFO_0022059
Disease	dibutyl phthalate measurement	UGCG PLEK GSDMC	6.77e-04	73	69	3	EFO_0022058
Disease	environmental exposure measurement	UGCG PLEK GSDMC	6.77e-04	73	69	3	EFO_0008360
Disease	DDT metabolite measurement	UGCG PLEK GSDMC	7.04e-04	74	69	3	EFO_0007886
Disease	Abnormality of refraction	SEMA4D DNAJC13 PHF19 RRP1B KDM5A PLCH2 PARD3	9.87e-04	673	69	7	HP_0000539
Disease	Adenocarcinoma of large intestine	MARK4 AKT2 ROS1	1.50e-03	96	69	3	C1319315
Disease	blood cobalt measurement	UGCG PLEK GSDMC	1.73e-03	101	69	3	EFO_0007577
Disease	cerebral white matter volume change measurement, age at assessment	KMT2A VIT	1.96e-03	28	69	2	EFO_0008007, EFO_0021499

Protein segments in the cluster

Peptide	Gene	Start	Entry
IPGVGGKTRLEKQFK	PTPRG	1141	P23470
KLLGKGTFGKVILVR	AKT2	156	P31751
QKNKVGERKGLVSRG	FAM228A	171	Q86W67
GKKLGLGTVVGLVNK	ASH1L	356	Q9NR48
LGKGAFGAVIKVQNK	EIF2AK4	596	Q9P2K8
KVRVITLVKNRGKGG	ALG5	131	Q9Y673
GQGQGESLRVKKKAL	GSDMC	191	Q9BYG8
LLRGKQGGFENKKRI	GSDME	236	O60443
QGNLGGNKKKIRGKR	ADAM22	836	Q9P0K1
QEVRKHLKGVLGGRK	CELSR1	2706	Q9NYQ6
QGKLTKLAVQIGKAG	ATP2B3	361	Q16720
GKIGKLQGVQRIKVS	ATP7A	191	Q04656
LNRGVIKQVKGKGAS	HP1BP3	211	Q5SSJ5
TLGIANKGGKRKQLY	NBEAL1	606	Q6ZS30
FKLQVIIIGSRGVGK	RAB12	41	Q6IQ22
FLTKKLNIGGKRVNL	RAB21	56	Q9UL25
GSKIINVGGKYVKLQ	RAB4A	51	P20338
SKKFKILIEGVLGQG	MAMDC2	136	Q7Z304
IKKGILLQLFGGTRK	MCM4	476	P33991
KKKGNIFIGIVGVQP	MSH3	381	P20585
NLVGKVIGKNGKVIQ	FXR2	301	P51116
NLVGKVIGKNGKVIQ	FXR1	291	P51114
GQGGKIRHFVSLKKL	PDE8B	366	O95263
FLKQKGIQSLGVKGR	PARP4	1606	Q9UKK3
LKKLQIFGAGPKVVG	KDM5A	236	P29375
SAGGGQKVRLLKKAL	PLOD1	71	Q02809
TKVVNGCRLGKIKNL	QTRT2	6	Q9H974
IKALFRKGKVLAQQG	FKBP8	306	Q14318
NLVGKVIGKNGKLIQ	FMR1	291	Q06787
LGRNTIKKGKYIKIG	DNAH17	3501	Q9UFH2
LVLGGFGKRKAPKVQ	DDX51	161	Q8N8A6
FGNKQKVLGKALSLI	BTBD1	261	Q9H0C5
KTQGKLNTRPGKVIF	CRYBG2	976	Q8N1P7
RLFIGGKKVGINPKI	UGCG	111	Q16739
GVKVVKALKRSNNGI	DNAJC13	456	O75165
LLRTIGKGNFAKVKL	MARK4	61	Q96L34
KTGKLQIGRKGVQIV	KMT2A	286	Q03164
AIQLEKGGKFTVRGK	SPAM1	406	P38567
KFKIGFLRLGQIQKV	DNA2	691	P51530
RGQGIGSKIIKKVAE	SAT2	101	Q96F10
RKKGLLKGQTGFRIF	GABRR2	421	P28476
KEGFGLGLQLKKILG	PARP6	121	Q2NL67
IGKRLNIQLKKGTEG	PARD3	456	Q8TEW0
FLQKLRQKIKIGVVG	PMM2	31	O15305
IFQNKKRVLLGETGK	RPS11	16	P62280
GGAQLLKRKRKLGVV	RRP1B	516	Q14684
AKVVRGFQLKLGKVS	SH3BP4	556	Q9P0V3
QGKTAGLVKASGRKL	ITIH3	121	Q06033
FRGVIIKQGCLLKQG	PLEK	241	P08567
AVIGKGGKNIKALRT	HNRNPK	56	P61978
TKGFLGLNKIKGLAR	SIK1B	596	A0A0B4J2F2
TKGFLGLNKIKGLAR	SIK1	596	P57059
GIRGLFKKAGKLNIT	SLC12A1	856	Q13621
RGLVQKRGKKQLGSL	SURF2	221	Q15527
VCKGDQGGLRTLQKK	SEMA4D	256	Q92854
QQKGGKGRKKLRLFE	SPIC	101	Q8N5J4
RAIKKLKALGTGFGI	SNF8	146	Q96H20
INRKVLGSRVFGNKK	COASY	421	Q13057
LGSRVFGNKKQLKIL	COASY	426	Q13057
GKVKQALGLKGLFLR	PLCH2	886	O75038
VLGFTGGKLIQRKKQ	STX17	266	P56962
KILVRKVAGQSGYKG	VIT	101	Q6UXI7
KGGALKKGAIARTLQ	PHF19	156	Q5T6S3
KKGNGAIVSQVKALR	ROS1	1411	P08922
FTKGKRGKRLGILVV	TEX261	166	Q6UWH6
ACKKGFIQRISKGGL	TFPI	266	P10646
FIQRISKGGLIKTKR	TFPI	271	P10646
LGSGKIQVSKKIGQR	SLF1	721	Q9BQI6
GMGRIFKGNLLQKKA	SMIM21	26	Q3B7S5
KREKNVGVFQKSLGL	TOPAZ1	1076	Q8N9V7
SVGIQAKVKAFGKRL	THAP10	191	Q9P2Z0
AKGKGLFATQLIRKG	SMYD5	31	Q6GMV2
VLRKKGYIVGINLGK	TSSK2	6	Q96PF2
GKAQGKGIFLINKLS	TTLL1	141	O95922