Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	signal release from synapse	STXBP2 SYT8 GRM4 NRXN2 OTOF	3.18e-05	195	39	5	GO:0099643
GeneOntologyBiologicalProcess	neurotransmitter secretion	STXBP2 SYT8 GRM4 NRXN2 OTOF	3.18e-05	195	39	5	GO:0007269
GeneOntologyBiologicalProcess	neurotransmitter transport	STXBP2 SYT8 GRM4 NRXN2 OTOF	1.22e-04	259	39	5	GO:0006836
MousePheno	epididymis epithelium degeneration	BMP8B BMP8A	1.72e-05	3	34	2	MP:0004934
MousePheno	absent primordial germ cells	BMP8B MAD2L2	8.56e-05	6	34	2	MP:0008393
MousePheno	epididymis degeneration	BMP8B BMP8A	1.20e-04	7	34	2	MP:0004935
Domain	Inhibin_asu	BMP8B BMP8A	3.61e-04	13	41	2	IPR002405
Domain	TGFb_propeptide	BMP8B BMP8A	1.71e-03	28	41	2	PF00688
Domain	TGF-b_N	BMP8B BMP8A	1.71e-03	28	41	2	IPR001111
Domain	ZnF_U1	ZFR RBM20	1.84e-03	29	41	2	SM00451
Domain	Znf_U1	ZFR RBM20	1.84e-03	29	41	2	IPR003604
Domain	TGF-beta-rel	BMP8B BMP8A	2.24e-03	32	41	2	IPR015615
Domain	TGFb_CS	BMP8B BMP8A	2.24e-03	32	41	2	IPR017948
Domain	C2	SYT8 OTOF PLCH2	2.96e-03	131	41	3	PF00168
Domain	TGFB	BMP8B BMP8A	2.98e-03	37	41	2	SM00204
Domain	TGF_BETA_2	BMP8B BMP8A	2.98e-03	37	41	2	PS51362
Domain	TGF_beta	BMP8B BMP8A	2.98e-03	37	41	2	PF00019
Domain	TGF-b_C	BMP8B BMP8A	2.98e-03	37	41	2	IPR001839
Domain	TGF_BETA_1	BMP8B BMP8A	2.98e-03	37	41	2	PS00250
Domain	C2	SYT8 OTOF PLCH2	3.36e-03	137	41	3	SM00239
Domain	C2	SYT8 OTOF PLCH2	3.71e-03	142	41	3	PS50004
Domain	-	SYT8 OTOF PLCH2	4.17e-03	148	41	3	2.60.40.150
Domain	C2_dom	SYT8 OTOF PLCH2	5.55e-03	164	41	3	IPR000008
Domain	-	BMP8B BMP8A	9.50e-03	67	41	2	2.10.90.10
Domain	Cystine-knot_cytokine	BMP8B BMP8A	9.50e-03	67	41	2	IPR029034
Domain	BBOX	TRIM49 TRIM49C	1.01e-02	69	41	2	SM00336
Domain	Butyrophylin	TRIM49 TRIM49C	1.03e-02	70	41	2	IPR003879
Domain	-	TRIM49 TRIM49C	1.06e-02	71	41	2	4.10.45.10
Domain	zf-B_box	TRIM49 TRIM49C	1.09e-02	72	41	2	PF00643
Domain	ConA-like_dom	TRIM49 NRXN2 TRIM49C	1.22e-02	219	41	3	IPR013320
Domain	ZF_BBOX	TRIM49 TRIM49C	1.33e-02	80	41	2	PS50119
Domain	Znf_B-box	TRIM49 TRIM49C	1.37e-02	81	41	2	IPR000315
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	WDR19 KDM2B IGSF9 KEAP1 NRXN2 KIAA1614 PLCH2 DDHD1	1.67e-07	529	41	8	14621295
Pubmed	Human BMP8A suppresses luteinization of rat granulosa cells via the SMAD1/5/8 pathway.	BMP8B BMP8A	1.36e-06	2	41	2	31940275
Pubmed	The protective role of bone morphogenetic protein-8 in the glucocorticoid-induced apoptosis on bone cells.	BMP8B BMP8A	1.36e-06	2	41	2	21277400
Pubmed	Bone morphogenetic protein 8A plays a role in the maintenance of spermatogenesis and the integrity of the epididymis.	BMP8B BMP8A	1.36e-06	2	41	2	9463357
Pubmed	The gene encoding bone morphogenetic protein 8B is required for the initiation and maintenance of spermatogenesis in the mouse.	BMP8B BMP8A	1.36e-06	2	41	2	8682296
Pubmed	Evidence that Mothers-against-dpp-related 1 (Madr1) plays a role in the initiation and maintenance of spermatogenesis in the mouse.	BMP8B BMP8A	4.06e-06	3	41	2	9076678
Pubmed	Requirement of Bmp8b for the generation of primordial germ cells in the mouse.	BMP8B BMP8A	4.06e-06	3	41	2	10894154
Pubmed	Osteogenic activity of the fourteen types of human bone morphogenetic proteins (BMPs).	BMP8B BMP8A	4.06e-06	3	41	2	12925636
Pubmed	BMP8B increases brown adipose tissue thermogenesis through both central and peripheral actions.	BMP8B BMP8A	4.06e-06	3	41	2	22579288
Pubmed	Mutation in Bmp7 exacerbates the phenotype of Bmp8a mutants in spermatogenesis and epididymis.	BMP8B BMP8A	4.06e-06	3	41	2	11784057
Pubmed	Estrogen mediated epithelial proliferation in the uterus is directed by stromal Fgf10 and Bmp8a.	BMP8B BMP8A	4.06e-06	3	41	2	25451979
Pubmed	Characterization and chromosomal localization of PTPRO, a novel receptor protein tyrosine phosphatase, expressed in hematopoietic stem cells.	BMP8B BMP8A	8.12e-06	4	41	2	9434160
Pubmed	Evidence that mouse Bmp8a (Op2) and Bmp8b are duplicated genes that play a role in spermatogenesis and placental development.	BMP8B BMP8A	8.12e-06	4	41	2	8843393
Pubmed	Amyloid precursor protein regulates netrin-1-mediated commissural axon outgrowth.	ZBTB20 DCC	1.35e-05	5	41	2	22782894
Pubmed	EZH2 and BCL6 Cooperate to Assemble CBX8-BCOR Complex to Repress Bivalent Promoters, Mediate Germinal Center Formation and Lymphomagenesis.	KDM2B ZFR YLPM1	1.95e-05	44	41	3	27505670
Pubmed	Conserved chromosomal location and genomic structure of human and mouse fatty-acid amide hydrolase genes and evaluation of clasper as a candidate neurological mutation.	BMP8B BMP8A	2.03e-05	6	41	2	9878243
Pubmed	Colocalization of BMP 7 and BMP 2 RNAs suggests that these factors cooperatively mediate tissue interactions during murine development.	BMP8B BMP8A	2.03e-05	6	41	2	7605753
Pubmed	The Bmp8 gene is expressed in developing skeletal tissue and maps near the Achondroplasia locus on mouse chromosome 4.	BMP8B BMP8A	2.84e-05	7	41	2	9070944
Pubmed	Characterisation of the mouse diabetes susceptibilty locus Nidd/SJL: islet cell destruction, interaction with the obesity QTL Nob1, and effect of dietary fat.	BMP8B BMP8A	2.84e-05	7	41	2	12107726
Pubmed	Gene structure and evolution of testicular haploid germ cell-specific genes, Oxct2a and Oxct2b.	BMP8B BMP8A	4.86e-05	9	41	2	15028287
Pubmed	Osteogenic protein-2. A new member of the transforming growth factor-beta superfamily expressed early in embryogenesis.	BMP8B BMP8A	4.86e-05	9	41	2	1460021
Pubmed	Ermap, a gene coding for a novel erythroid specific adhesion/receptor membrane protein.	BMP8B BMP8A	7.41e-05	11	41	2	10721728
Pubmed	Bmp7 regulates germ cell proliferation in mouse fetal gonads.	BMP8B BMP8A	1.05e-04	13	41	2	18391523
Pubmed	Human chromosome 11 DNA sequence and analysis including novel gene identification.	TRIM49 NRXN2 TRIM49C	1.17e-04	80	41	3	16554811
Pubmed	New Dyscalc loci for myocardial cell necrosis and calcification (dystrophic cardiac calcinosis) in mice.	BMP8B BMP8A	1.22e-04	14	41	2	11526197
Pubmed	Trim43a, Trim43b, and Trim43c: Novel mouse genes expressed specifically in mouse preimplantation embryos.	TRIM49 TRIM49C	1.41e-04	15	41	2	19703589
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	ZFR KEAP1 STBD1 PLCH2 YLPM1	1.47e-04	430	41	5	35044719
Pubmed	Global comparative transcriptome analysis of cartilage formation in vivo.	BMP8B BMP8A	1.61e-04	16	41	2	19272164
Pubmed	Mili, a mammalian member of piwi family gene, is essential for spermatogenesis.	BMP8B BMP8A	1.82e-04	17	41	2	14736746
Pubmed	Dysfunction of programmed embryo senescence is linked to genetic developmental defects.	BMP8B BMP8A	2.05e-04	18	41	2	37017267
Pubmed	Identification of a genomic reservoir for new TRIM genes in primate genomes.	TRIM49 TRIM49C	2.29e-04	19	41	2	22144910
Pubmed	KDM2B regulates hippocampal morphogenesis by transcriptionally silencing Wnt signaling in neural progenitors.	KDM2B ZBTB20	6.17e-04	31	41	2	37838801
Pubmed	Forkhead box a2 (FOXA2) is essential for uterine function and fertility.	BMP8B BMP8A	7.00e-04	33	41	2	28049832
Pubmed	Integrated Transcriptome and Network Analysis Reveals Spatiotemporal Dynamics of Calvarial Suturogenesis.	BMP8B BMP8A	7.00e-04	33	41	2	32640236
Pubmed	Phox2a Defines a Developmental Origin of the Anterolateral System in Mice and Humans.	POU6F2 DCC	1.03e-03	40	41	2	33238113
Pubmed	Human variation in alcohol response is influenced by variation in neuronal signaling genes.	POU6F2 GRM4 CNGB1	1.09e-03	171	41	3	20201926
GeneFamily	Bone morphogenetic proteins\|Astacins	BMP8B BMP8A	1.26e-04	11	28	2	455
GeneFamily	WD repeat domain containing	WDR19 DCAF6 EML4	7.54e-03	262	28	3	362
GeneFamily	PHD finger proteins	SHPRH KDM2B	8.52e-03	90	28	2	88
GeneFamily	Ring finger proteins	SHPRH TRIM49 TRIM49C	8.61e-03	275	28	3	58
GeneFamily	Ring finger proteins\|Tripartite motif containing\|ARF GTPase family	TRIM49 TRIM49C	9.45e-03	95	28	2	59
GeneFamily	Basic leucine zipper proteins\|BTB domain containing	ZBTB20 KEAP1	1.82e-02	134	28	2	861
CoexpressionAtlas	FacebaseRNAseq_e10.5_Medial Nasal Eminence_top-relative-expression-ranked_500	BMP8B POU6F2 ZBTB20 SYT8 NRXN2 ALS2CL PLCH2	2.64e-05	488	39	7	Facebase_RNAseq_e10.5_Medial Nasal Eminence_500
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	POU6F2 BMP8A DCC CNGB1 PLCH2	4.87e-07	170	41	5	3174ea9cf93892a8b41de10fd4ff6f06bb41502d
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2-Exc_L3-4_RORB_SEMA6D\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	POU6F2 BMP8A DCC CNGB1 PLCH2	5.31e-07	173	41	5	9a2d42f8d9cb834856522661d524abb91c4637c5
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2-Exc_L3-4_RORB_PRSS12\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	POU6F2 BMP8A DCC GRM4 CNGB1	5.31e-07	173	41	5	8ac2e9d39c0f76e674f8bd59d1da246bab4867c8
ToppCell	Neuronal-Excitatory-eC(RORB)-eC_1-FILIP1L\|Neuronal / cells hierarchy compared to all cells using T-Statistic	POU6F2 BMP8A DCC CNGB1 PLCH2	1.09e-06	200	41	5	f6af5ef02625aaae21e885e1ebd195e34731e53a
ToppCell	Neuronal-Excitatory-eC(RORB)-eC_1-FILIP1L-\|Neuronal / cells hierarchy compared to all cells using T-Statistic	POU6F2 BMP8A DCC CNGB1 PLCH2	1.09e-06	200	41	5	53f61e28c3ad6399f63c54e06120ecb5ebbf90d9
ToppCell	Neuronal-Excitatory-eC(RORB)-eC_1-FILIP1L--L3-5\|Neuronal / cells hierarchy compared to all cells using T-Statistic	POU6F2 BMP8A DCC CNGB1 PLCH2	1.09e-06	200	41	5	c1f243ae929f7791e040437470033abf749b44cc
ToppCell	5'-Adult-LymphNode-Hematopoietic-Plasma_cells-IgA_plasma_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	LIME1 BMP8A DCC TOR3A	1.41e-05	160	41	4	e44b3c74c76b4632ada7f5bd6d09434b02d79743
ToppCell	Basal_cells-SSc-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	IGSF9 SYT8 KIAA1614 PLCH2	1.55e-05	164	41	4	85487a303194f5244956ec1ca2d1758d38117f41
ToppCell	5'-Adult-LymphNode-Hematopoietic-Plasma_cells-IgG_plasma_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	LIME1 BMP8A DCC TOR3A	1.71e-05	168	41	4	f5a18123f84c62211d9279e9c41e90122e4c4895
ToppCell	5'-Adult-LymphNode-Hematopoietic-Plasma_cells\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	LIME1 BMP8A DCC TOR3A	2.00e-05	175	41	4	6a093c74a6f3daeff07759d6eec542fc5c709149
ToppCell	droplet-Liver-LIVER_HEP-30m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WDR19 ART5 CNGB1 DDHD1	2.05e-05	176	41	4	5e46a09a36b9645b1b1fcb0b64bd0898561af3a9
ToppCell	cellseq2-Immune-Lymphocytic_B-Lymphocytic_B-Plasma\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	LIME1 BMP8B DCC TOR3A	2.65e-05	188	41	4	33360f1c30315d9772731c9067834dc059172b79
ToppCell	cellseq2-Immune-Lymphocytic_B-Lymphocytic_B\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	LIME1 BMP8B DCC TOR3A	2.82e-05	191	41	4	17746a32f723c078aba1f7e320b0e3f1ab8bf5c6
ToppCell	cellseq2-Immune-Lymphocytic_B\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	LIME1 BMP8B DCC TOR3A	2.82e-05	191	41	4	c2c450df810f83163987cd0f7ed9b50025cd3de1
ToppCell	NS-moderate-d_16-33-Myeloid-Monocyte-derived_Macrophage\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	HELZ2 STXBP2 TCN2 OTOF	3.06e-05	195	41	4	d87c83d2d421c9291d0a10bc9db850e9fb337667
ToppCell	moderate-Myeloid-Monocyte-derived_Macrophage\|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	HELZ2 STXBP2 TCN2 OTOF	3.06e-05	195	41	4	9c9634906168239cf978adb398787692437bf9e7
ToppCell	Parenchyma_Control_(B.)-Epithelial-TX-Basal_1\|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type	IGSF9 SYT8 CNGB1 PLCH2	3.18e-05	197	41	4	2701864e49878c5f323f5133e2c4b0a5a7fff7f5
ToppCell	Lung_Parenchyma-Control-Epithelial-Epithelial-Basal_1\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	IGSF9 SYT8 CNGB1 PLCH2	3.18e-05	197	41	4	751f19b00f92e1334f653b870d3f7c0c149ff41a
ToppCell	Lung_Parenchyma-Control-Epithelial-Epithelial-Basal_1-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	IGSF9 SYT8 CNGB1 PLCH2	3.18e-05	197	41	4	58d809ccb8cc4b1e76acf0b8f996cd0e2637290c
Disease	diabetes mellitus (implicated_via_orthology)	BMP8B BMP8A	5.70e-04	26	40	2	DOID:9351 (implicated_via_orthology)
Disease	forced expiratory volume	POU6F2 ZFAT BMP8A DCC EML4 RBM20	6.34e-04	789	40	6	EFO_0004314
Disease	acute lymphoblastic leukemia (is_marker_for)	KDM2B TCN2	9.78e-04	34	40	2	DOID:9952 (is_marker_for)
Disease	retinitis pigmentosa (is_implicated_in)	WDR19 CNGB1	1.42e-03	41	40	2	DOID:10584 (is_implicated_in)
Disease	Hepatomegaly	PEPD KEAP1	2.45e-03	54	40	2	C0019209
Disease	response to alcohol	ZFAT CNGB1	4.67e-03	75	40	2	EFO_0005526
Disease	feeling "fed-up" measurement	DCC YLPM1	4.79e-03	76	40	2	EFO_0009588
Disease	Autistic Disorder	POU6F2 NRXN2 TCN2	5.31e-03	261	40	3	C0004352

Protein segments in the cluster

Peptide	Gene	Start	Entry
EDMRLHRLPGHWHSR	ALS2CL	936	Q60I27
HIMDEHWRGEALREK	CNTRL	2226	Q7Z7A1
TDHLHLRIERMHWPG	GRM4	496	Q14833
WDRHTAEHLMLLEAD	DCAF6	746	Q58WW2
RDRMDPWAHDRKHHP	RBM20	701	Q5T481
WPDMHRLADRIHLEE	PEPD	326	P12955
KDLRPPDLWIHHEEM	DCC	1146	P43146
WILADEQDVHMHDPR	MAD2L2	171	Q9UI95
EPRLHMEWIRETHIG	KIAA1614	586	Q5VZ46
PVADDRWHMVLLTRD	NRXN2	106	Q9P2S2
PLDDGAAHVMHREVW	KDM2B	1056	Q8NHM5
MVERDRALGHQEPHW	BMP8A	111	Q7Z5Y6
ERDEWHLVAPMLTRR	KEAP1	446	Q14145
SMEHRLEWTRLVDEP	EML4	621	Q9HC35
LPDERWMSYEERHLL	DDHD1	566	Q8NEL9
RNLALGHPEEMERWH	HELZ2	281	Q9BYK8
MVERDRALGHQEPHW	BMP8B	111	P34820
MLRHSPSLWELVEEH	CCDC24	1	Q8N4L8
EHVALLALRHWEDIP	OTOF	1661	Q9HC10
LQHWADMLAHARRPI	SYT8	356	Q8NBV8
HRPIEWAAEEHREKL	TRIM49	126	P0CI25
PVLERWMAEAEARHR	POU6F2	576	P78424
LHWNMHEDRRNEPII	SHPRH	21	Q149N8
PIAALEMRRDLQHWD	WDR19	746	Q8NEZ3
QHLLPWMDRLSLEHL	TCN2	36	P20062
DPARLVAWVLHRLEM	CNGB1	251	Q14028
DDGLWITLLHLDHMR	RWDD3	136	Q9Y3V2
ELDRDRHMLVHGDKW	ZFAT	416	Q9P243
DRVDHEEWEMVPRHS	STBD1	196	O95210
HMPEIALVRFLVWDH	PLCH2	826	O75038
HRPIEWAAEEHREKL	TRIM49C	126	P0CI26
LDEDDDLWVELRHMH	STXBP2	281	Q15833
LAKRPDRMHHDWVSL	IGSF9	546	Q9P2J2
HVWCHPEEEERMHDE	ZNF829	11	Q3KNS6
HWETAPRHMMRLDIR	YLPM1	1986	P49750
LPRDHHMEDPSWITR	ZBTB20	276	Q9HC78
HMEDPSWITRIHERS	ZBTB20	281	Q9HC78
MEEEQHHWDDRRRMP	ZFR	671	Q96KR1
GWSREEITMEHLEPH	TOR3A	291	Q9H497
PEEQEHMRRWLHERF	AGPAT5	271	Q9NUQ2
MDLLRPHWLEVSRDI	LIME1	96	Q9H400
EEMAHHALLRESWEA	ART5	56	Q96L15