Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	signal transduction in response to DNA damage	HINFP TICRR ABL1 ATR MAP3K20 GRB2 CDK1	2.37e-05	200	88	7	GO:0042770
GeneOntologyBiologicalProcess	cell junction assembly	ABL1 NRXN3 SHANK2 LGI2 SIPA1L1 ADGRB1 MDGA2 TSC1 NPHP4 ITGB4 VCL	3.00e-05	569	88	11	GO:0034329
Domain	SPAR_C	SIPA1L1 SIPA1L3 SIPA1L2	9.10e-08	3	85	3	PF11881
Domain	SIPA1L_C	SIPA1L1 SIPA1L3 SIPA1L2	9.10e-08	3	85	3	IPR021818
Domain	Rap_GAP	SIPA1L1 SIPA1L3 SIPA1L2	1.07e-05	10	85	3	PF02145
Domain	Rap_GAP_dom	SIPA1L1 SIPA1L3 SIPA1L2	1.46e-05	11	85	3	IPR000331
Domain	RAPGAP	SIPA1L1 SIPA1L3 SIPA1L2	1.46e-05	11	85	3	PS50085
Domain	FABD	ABL1 ABL2	2.05e-05	2	85	2	SM00808
Domain	F_actin_bind	ABL1 ABL2	2.05e-05	2	85	2	PF08919
Domain	F-actin_binding	ABL1 ABL2	2.05e-05	2	85	2	IPR015015
Domain	MBT	L3MBTL1 L3MBTL2	7.22e-04	9	85	2	SM00561
Domain	MBT	L3MBTL1 L3MBTL2	7.22e-04	9	85	2	PS51079
Domain	MBT	L3MBTL1 L3MBTL2	9.00e-04	10	85	2	PF02820
Domain	Mbt	L3MBTL1 L3MBTL2	9.00e-04	10	85	2	IPR004092
Domain	PROTEIN_KINASE_TYR	BMX ABL1 ABL2 PRAG1	1.00e-03	97	85	4	PS00109
Domain	Tyr_kinase_AS	BMX ABL1 ABL2 PRAG1	1.00e-03	97	85	4	IPR008266
Domain	KRAB_RELATED	SSX9P SSX1	1.10e-03	11	85	2	PS50806
Domain	SH2	BMX ABL1 ABL2 GRB2	1.17e-03	101	85	4	PF00017
Domain	Krueppel-associated_box-rel	SSX9P SSX1	1.55e-03	13	85	2	IPR003655
Domain	SH2	BMX ABL1 ABL2 GRB2	1.60e-03	110	85	4	SM00252
Domain	SH2	BMX ABL1 ABL2 GRB2	1.65e-03	111	85	4	PS50001
Domain	SH2	BMX ABL1 ABL2 GRB2	1.71e-03	112	85	4	IPR000980
Domain	-	BMX ABL1 ABL2 GRB2	1.71e-03	112	85	4	3.30.505.10
Domain	Pkinase_Tyr	BMX ABL1 ABL2 MAP3K20	2.86e-03	129	85	4	PF07714
Domain	Chromodomain_CS	CHD1 CBX4	2.99e-03	18	85	2	IPR023779
Domain	Ser-Thr/Tyr_kinase_cat_dom	BMX ABL1 ABL2 MAP3K20	3.64e-03	138	85	4	IPR001245
Domain	SAM_1	L3MBTL1 SHANK2 MAP3K20	3.68e-03	68	85	3	PF00536
Domain	PDZ	SHANK2 SIPA1L1 SIPA1L3 SIPA1L2	3.93e-03	141	85	4	PF00595
Domain	PDZ	SHANK2 SIPA1L1 SIPA1L3 SIPA1L2	4.67e-03	148	85	4	SM00228
Domain	-	SHANK2 SIPA1L1 SIPA1L3 SIPA1L2	4.89e-03	150	85	4	2.30.42.10
Domain	PDZ	SHANK2 SIPA1L1 SIPA1L3 SIPA1L2	5.01e-03	151	85	4	PS50106
Domain	PDZ	SHANK2 SIPA1L1 SIPA1L3 SIPA1L2	5.13e-03	152	85	4	IPR001478
Domain	Chromo_domain	CHD1 CBX4	5.29e-03	24	85	2	IPR023780
Domain	Chromo	CHD1 CBX4	6.20e-03	26	85	2	PF00385
Domain	CHROMO_1	CHD1 CBX4	7.17e-03	28	85	2	PS00598
Domain	CHROMO_2	CHD1 CBX4	7.17e-03	28	85	2	PS50013
Domain	TyrKc	BMX ABL1 ABL2	7.56e-03	88	85	3	SM00219
Domain	SAM	L3MBTL1 SHANK2 MAP3K20	7.56e-03	88	85	3	SM00454
Domain	Tyr_kinase_cat_dom	BMX ABL1 ABL2	7.56e-03	88	85	3	IPR020635
Pubmed	RapGAPs in brain: multipurpose players in neuronal Rap signalling.	SIPA1L1 SIPA1L3 SIPA1L2	1.68e-08	3	90	3	20576033
Pubmed	c-Abl kinase regulates the protein binding activity of c-Crk.	ABL1 ABL2 GRB2	6.69e-08	4	90	3	8194526
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	BMX ABL1 ABL2 ERCC6L STARD9 SIPA1L1 SIPA1L3 MAP3K20 CEP192 MPHOSPH9 CBX4 SIPA1L2 PRAG1	3.40e-07	861	90	13	36931259
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	LENG8 L3MBTL2 ERCC6L SMCHD1 GART PRPF38B TSC1 CHD1 SIPA1L2 CHAMP1 TOP1 XAB2 VCL	8.48e-07	934	90	13	33916271
Pubmed	SRC Homology 2 Domain Binding Sites in Insulin, IGF-1 and FGF receptor mediated signaling networks reveal an extensive potential interactome.	BMX ABL1 ABL2 GRB2	1.43e-06	32	90	4	22974441
Pubmed	The human cytoplasmic dynein interactome reveals novel activators of motility.	LENG8 TBC1D31 ABL2 L3MBTL2 SIPA1L1 SIPA1L3 TSC1 CEP192 MPHOSPH9 SIPA1L2 CPLANE1 VCL	2.08e-06	853	90	12	28718761
Pubmed	Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.	LENG8 SMCHD1 CHD1 CBX4 GREB1 CHAMP1 TOP1 XAB2	3.03e-06	341	90	8	32971831
Pubmed	SR protein kinases promote splicing of nonconsensus introns.	RBM19 SMCHD1 SIPA1L3 MAP3K20 PRPF38B PKD1L2 CPLANE1 TOP1	4.61e-06	361	90	8	26167880
Pubmed	Transcription factor Foxp3 and its protein partners form a complex regulatory network.	LENG8 ATR RBM19 SMCHD1 SIPA1L1 CBX4 TOP1 XAB2	5.52e-06	370	90	8	22922362
Pubmed	Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development.	BMX OXA1L L3MBTL2 RBM19 GART PRPF38B CHD1 SIPA1L2 TASOR2	5.77e-06	496	90	9	31343991
Pubmed	Integrin-mediated dendrite branch maintenance requires Abelson (Abl) family kinases.	ABL1 ABL2	6.62e-06	2	90	2	15987940
Pubmed	c-Abl and Arg tyrosine kinases regulate lysosomal degradation of the oncoprotein Galectin-3.	ABL1 ABL2	6.62e-06	2	90	2	20150913
Pubmed	ATR inhibitors VE-821 and VX-970 sensitize cancer cells to topoisomerase i inhibitors by disabling DNA replication initiation and fork elongation responses.	ATR TOP1	6.62e-06	2	90	2	25269479
Pubmed	Phosphorylation of DNA topoisomerase I by the c-Abl tyrosine kinase confers camptothecin sensitivity.	ABL1 TOP1	6.62e-06	2	90	2	15448168
Pubmed	The Abl and Arg kinases mediate distinct modes of phagocytosis and are required for maximal Leishmania infection.	ABL1 ABL2	6.62e-06	2	90	2	22665498
Pubmed	Global Regulation of Differential Gene Expression by c-Abl/Arg Oncogenic Kinases.	ABL1 ABL2	6.62e-06	2	90	2	28555614
Pubmed	The expression of the non-receptor tyrosine kinases Arg and c-abl is differently modulated in B lymphoid cells at different stages of differentiation.	ABL1 ABL2	6.62e-06	2	90	2	12220663
Pubmed	Loss of dendrite stabilization by the Abl-related gene (Arg) kinase regulates behavioral flexibility and sensitivity to cocaine.	ABL1 ABL2	6.62e-06	2	90	2	19805386
Pubmed	c-Abl and Arg are activated in human primary melanomas, promote melanoma cell invasion via distinct pathways, and drive metastatic progression.	ABL1 ABL2	6.62e-06	2	90	2	21892207
Pubmed	Integrin β4 and vinculin contained in exosomes are potential markers for progression of prostate cancer associated with taxane-resistance.	ITGB4 VCL	6.62e-06	2	90	2	25997717
Pubmed	Inhibition of cell migration by Abl family tyrosine kinases through uncoupling of Crk-CAS complexes.	ABL1 ABL2	6.62e-06	2	90	2	11279004
Pubmed	Predominant expression of murine Bmx tyrosine kinase in the granulo-monocytic lineage.	BMX ABL2	6.62e-06	2	90	2	9373244
Pubmed	Abl tyrosine kinase promotes dorsal ruffles but restrains lamellipodia extension during cell spreading on fibronectin.	ABL1 ABL2	6.62e-06	2	90	2	17686996
Pubmed	ABL tyrosine kinases: evolution of function, regulation, and specificity.	ABL1 ABL2	6.62e-06	2	90	2	20841568
Pubmed	Differential phosphorylation of c-Abl in cell cycle determined by cdc2 kinase and phosphatase activity.	ABL1 CDK1	6.62e-06	2	90	2	2183353
Pubmed	Inhibition of Grb2 expression demonstrates an important role in BCR-ABL-mediated MAPK activation and transformation of primary human hematopoietic cells.	ABL1 GRB2	6.62e-06	2	90	2	21072043
Pubmed	Combating acquired resistance to MAPK inhibitors in melanoma by targeting Abl1/2-mediated reactivation of MEK/ERK/MYC signaling.	ABL1 ABL2	6.62e-06	2	90	2	33122628
Pubmed	The vascular endothelial specific IL-4 receptor alpha-ABL1 kinase signaling axis regulates the severity of IgE-mediated anaphylactic reactions.	ABL1 IL4R	6.62e-06	2	90	2	29157947
Pubmed	Sipa1l3/SPAR3 is targeted to postsynaptic specializations and interacts with the Fezzin ProSAPiP1/Lzts3.	SIPA1L1 SIPA1L3	6.62e-06	2	90	2	26364583
Pubmed	The coupling of alpha6beta4 integrin to Ras-MAP kinase pathways mediated by Shc controls keratinocyte proliferation.	GRB2 ITGB4	6.62e-06	2	90	2	9171350
Pubmed	Abl family tyrosine kinases regulate sialylated ganglioside receptors for polyomavirus.	ABL1 ABL2	6.62e-06	2	90	2	20181697
Pubmed	Abl family nonreceptor tyrosine kinases modulate short-term synaptic plasticity.	ABL1 ABL2	6.62e-06	2	90	2	12626632
Pubmed	The Abl family kinases: mechanisms of regulation and signaling.	ABL1 ABL2	6.62e-06	2	90	2	12374288
Pubmed	Defective T cell development and function in the absence of Abelson kinases.	ABL1 ABL2	6.62e-06	2	90	2	18025176
Pubmed	Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	L3MBTL1 ZBED4 RBM19 SMCHD1 NPHP4	7.09e-06	102	90	5	9734811
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	ZBED4 LGI2 DNAJC16 STARD9 SIPA1L1 TSC1 CEP192 SIPA1L2	1.10e-05	407	90	8	12693553
Pubmed	Mutations in DONSON disrupt replication fork stability and cause microcephalic dwarfism.	TICRR ATR CDK1	1.33e-05	18	90	3	28191891
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	NRXN3 TBC1D31 SHANK2 ZBED4 STARD9 SMCHD1 SIPA1L3 SKIDA1 ANKRD30A TSC1 SIPA1L2 HSPA6 TOP1 TASOR2	1.97e-05	1442	90	14	35575683
Pubmed	Expression of the beta 4 integrin subunit induces monocytic differentiation of 32D/v-Abl cells.	ABL1 ITGB4	1.98e-05	3	90	2	12070014
Pubmed	Two distinct phosphorylation pathways have additive effects on Abl family kinase activation.	ABL1 ABL2	1.98e-05	3	90	2	12748290
Pubmed	Abl family kinases regulate FcγR-mediated phagocytosis in murine macrophages.	ABL1 ABL2	1.98e-05	3	90	2	23100514
Pubmed	Neuropilin-1 stimulates tumor growth by increasing fibronectin fibril assembly in the tumor microenvironment.	ABL1 ABL2	1.98e-05	3	90	2	22738912
Pubmed	Cell cycle-regulated phosphorylation of hamartin, the product of the tuberous sclerosis complex 1 gene, by cyclin-dependent kinase 1/cyclin B.	TSC1 CDK1	1.98e-05	3	90	2	14551205
Pubmed	SUMO-1 conjugation to topoisomerase I: A possible repair response to topoisomerase-mediated DNA damage.	UBE2I TOP1	1.98e-05	3	90	2	10759568
Pubmed	ArgBP2, a multiple Src homology 3 domain-containing, Arg/Abl-interacting protein, is phosphorylated in v-Abl-transformed cells and localized in stress fibers and cardiocyte Z-disks.	ABL1 ABL2	1.98e-05	3	90	2	9211900
Pubmed	Abi enhances Abl-mediated CDC2 phosphorylation and inactivation.	ABL1 CDK1	1.98e-05	3	90	2	15591787
Pubmed	Necdin downregulates CDC2 expression to attenuate neuronal apoptosis.	NDN CDK1	1.98e-05	3	90	2	17108174
Pubmed	Ubiquitination and degradation of the Arg tyrosine kinase is regulated by oxidative stress.	ABL1 ABL2	1.98e-05	3	90	2	15735735
Pubmed	Arg kinase regulates prefrontal dendritic spine refinement and cocaine-induced plasticity.	ABL1 ABL2	1.98e-05	3	90	2	22396406
Pubmed	S-adenosyl methionine regulates ubiquitin-conjugating enzyme 9 protein expression and sumoylation in murine liver and human cancers.	UBE2I CDK1	1.98e-05	3	90	2	22407595
Pubmed	Functional interaction between the c-Abl and Arg protein-tyrosine kinases in the oxidative stress response.	ABL1 ABL2	1.98e-05	3	90	2	12569093
Pubmed	Catalase is regulated by ubiquitination and proteosomal degradation. Role of the c-Abl and Arg tyrosine kinases.	ABL1 ABL2	1.98e-05	3	90	2	12950161
Pubmed	Grb2 and its apoptotic isoform Grb3-3 associate with heterogeneous nuclear ribonucleoprotein C, and these interactions are modulated by poly(U) RNA.	ABL1 GRB2	1.98e-05	3	90	2	9516488
Pubmed	An intrinsic S/G2 checkpoint enforced by ATR.	ATR CDK1	1.98e-05	3	90	2	30139873
Pubmed	PICH, a centromere-associated SNF2 family ATPase, is regulated by Plk1 and required for the spindle checkpoint.	ERCC6L CDK1	1.98e-05	3	90	2	17218258
Pubmed	Non-receptor tyrosine kinases c-Abl and Arg regulate the activity of C/EBPbeta.	ABL1 ABL2	1.98e-05	3	90	2	19563810
Pubmed	Glutathione peroxidase 1 is regulated by the c-Abl and Arg tyrosine kinases.	ABL1 ABL2	1.98e-05	3	90	2	12893824
Pubmed	Direct interaction of Jak1 and v-Abl is required for v-Abl-induced activation of STATs and proliferation.	ABL1 ABL2	1.98e-05	3	90	2	9774693
Pubmed	ATR promotes clearance of damaged DNA and damaged cells by rupturing micronuclei.	ATR CDK1	1.98e-05	3	90	2	37788673
Pubmed	ShcA regulates thymocyte proliferation through specific transcription factors and a c-Abl-dependent signaling axis.	ABL1 ABL2	1.98e-05	3	90	2	25691660
Pubmed	Catalase activity is regulated by c-Abl and Arg in the oxidative stress response.	ABL1 ABL2	1.98e-05	3	90	2	12777400
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	SLC6A6 TBC1D31 L3MBTL2 ERCC6L SEM1 DNAJC16 TSC1 CHD1 MPHOSPH9 VCL	2.04e-05	733	90	10	34672954
Pubmed	Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.	BMX ABL1 ABL2 SHANK2 GRB2 ZP2 NXPH3	2.43e-05	329	90	7	17474147
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	ABL1 SHANK2 ZBED4 PCNX4 RBM19 SIPA1L3 CEP192 SIPA1L2 NPHP4 PRAG1 ITGB4 IL4R	2.79e-05	1105	90	12	35748872
Pubmed	Tarp regulates early Chlamydia-induced host cell survival through interactions with the human adaptor protein SHC1.	ABL1 ABL2 GRB2	3.26e-05	24	90	3	20624904
Pubmed	L3MBTL1, a histone-methylation-dependent chromatin lock.	L3MBTL1 L3MBTL2 CHD1	3.26e-05	24	90	3	17540172
Pubmed	Direct role for the replication protein treslin (Ticrr) in the ATR kinase-mediated checkpoint response.	TICRR ATR	3.96e-05	4	90	2	23696651
Pubmed	Abl knockout differentially affects p130 Crk-associated substrate, vinculin, and paxillin in blood vessels of mice.	ABL1 VCL	3.96e-05	4	90	2	19542491
Pubmed	Characterization of non-canonical Polycomb Repressive Complex 1 subunits during early mouse embryogenesis.	L3MBTL1 L3MBTL2	3.96e-05	4	90	2	27081692
Pubmed	Abl family kinases modulate T cell-mediated inflammation and chemokine-induced migration through the adaptor HEF1 and the GTPase Rap1.	ABL1 ABL2	3.96e-05	4	90	2	22810897
Pubmed	c-ABL modulates MAP kinases activation downstream of VEGFR-2 signaling by direct phosphorylation of the adaptor proteins GRB2 and NCK1.	ABL1 GRB2	3.96e-05	4	90	2	22327338
Pubmed	Localization and phosphorylation of Abl-interactor proteins, Abi-1 and Abi-2, in the developing nervous system.	ABL1 ABL2	3.96e-05	4	90	2	10995551
Pubmed	The Src family kinase Hck interacts with Bcr-Abl by a kinase-independent mechanism and phosphorylates the Grb2-binding site of Bcr.	ABL1 GRB2	3.96e-05	4	90	2	9407116
Pubmed	A positive role for c-Abl in Atm and Atr activation in DNA damage response.	ABL1 ATR	3.96e-05	4	90	2	20798688
Pubmed	Arg interacts with cortactin to promote adhesion-dependent cell edge protrusion.	ABL1 ABL2	3.96e-05	4	90	2	19414610
Pubmed	Coexistence of phosphotyrosine-dependent and -independent interactions between Cbl and Bcr-Abl.	ABL1 GRB2	3.96e-05	4	90	2	14725908
Pubmed	Transient inhibition of p53 homologs protects ovarian function from two distinct apoptotic pathways triggered by anticancer therapies.	ABL1 ABL2	3.96e-05	4	90	2	29988075
Pubmed	Bidirectional signaling links the Abelson kinases to the platelet-derived growth factor receptor.	ABL1 ABL2	3.96e-05	4	90	2	14993293
Pubmed	ATR controls the UV-related upregulation of the CDKN1A mRNA in a Cdk1/HuR-dependent manner.	ATR CDK1	3.96e-05	4	90	2	23813879
Pubmed	Activation of extracellular signal-regulated kinase 2 by a novel Abl-binding protein, ST5.	ABL1 GRB2	3.96e-05	4	90	2	9632734
Pubmed	UHRF2, a ubiquitin E3 ligase, acts as a small ubiquitin-like modifier E3 ligase for zinc finger protein 131.	UBE2I CBX4	3.96e-05	4	90	2	23404503
Pubmed	Signal transduction by the alpha 6 beta 4 integrin: distinct beta 4 subunit sites mediate recruitment of Shc/Grb2 and association with the cytoskeleton of hemidesmosomes.	GRB2 ITGB4	3.96e-05	4	90	2	7556090
Pubmed	CDK1-mediated phosphorylation of Abi1 attenuates Bcr-Abl-induced F-actin assembly and tyrosine phosphorylation of WAVE complex during mitosis.	ABL1 CDK1	3.96e-05	4	90	2	21900237
Pubmed	The polycomb protein Pc2 is a SUMO E3.	UBE2I CBX4	3.96e-05	4	90	2	12679040
Pubmed	ALDH2 is associated to alcohol dependence and is the major genetic determinant of "daily maximum drinks" in a GWAS study of an isolated rural Chinese sample.	SIPA1L1 B3GAT1	3.96e-05	4	90	2	24277619
Pubmed	Reciprocal regulation of Abl and receptor tyrosine kinases.	ABL1 ABL2	3.96e-05	4	90	2	19275932
Pubmed	SHP-2 is a novel target of Abl kinases during cell proliferation.	ABL1 ABL2	3.96e-05	4	90	2	18827006
Pubmed	Abelson family kinases regulate Frizzled planar cell polarity signaling via Dsh phosphorylation.	ABL1 ABL2	3.96e-05	4	90	2	20837657
Pubmed	Compartmentalization of the SUMO/RNF4 pathway by SLX4 drives DNA repair.	UBE2I SMCHD1 GART CBX4 CHAMP1 HSPA6 XAB2	4.08e-05	357	90	7	37059091
Pubmed	Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry.	ABL1 ABL2 MAP3K20 CDK1	5.17e-05	78	90	4	17192257
Pubmed	New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing.	ABCA12 STARD9 SMCHD1 ADGRB1 FAM186B ITGB4 HSPA6 TOP1	5.71e-05	513	90	8	25798074
Pubmed	Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry.	ABL1 ABL2 CHD1	6.47e-05	30	90	3	12522270
Pubmed	Interaction between c-Abl and Arg tyrosine kinases and proteasome subunit PSMA7 regulates proteasome degradation.	ABL1 ABL2	6.59e-05	5	90	2	16678104
Pubmed	Abl protein-tyrosine kinase selects the Crk adapter as a substrate using SH3-binding sites.	ABL1 GRB2	6.59e-05	5	90	2	7926767
Pubmed	Proline-rich sequences mediate the interaction of the Arg protein tyrosine kinase with Crk.	ABL1 ABL2	6.59e-05	5	90	2	8875975
Pubmed	Hamartin and tuberin interaction with the G2/M cyclin-dependent kinase CDK1 and its regulatory cyclins A and B.	TSC1 CDK1	6.59e-05	5	90	2	11444800
Pubmed	Detection in primary chronic myeloid leukaemia cells of p210BCR-ABL1 in complexes with adaptor proteins CBL, CRKL, and GRB2.	ABL1 GRB2	6.59e-05	5	90	2	16955467
Pubmed	Mutant p53 perturbs DNA replication checkpoint control through TopBP1 and Treslin.	TICRR ATR	6.59e-05	5	90	2	28439015
Pubmed	Sphingosine 1-phosphate induces membrane ruffling and increases motility of human umbilical vein endothelial cells via vascular endothelial growth factor receptor and CrkII.	ABL1 ABL2	6.59e-05	5	90	2	11956190
Pubmed	An electrophoretic mobility shift assay identifies a mechanistically unique inhibitor of protein sumoylation.	UBE2I TOP1	6.59e-05	5	90	2	23601649
Interaction	PXN interactions	ABL1 ABL2 SIPA1L3 GART GRB2 CEP192 MPHOSPH9 SIPA1L2 PRAG1 HSPA6 VCL	1.78e-07	334	86	11	int:PXN
Interaction	YWHAH interactions	TICRR ABL1 ABL2 ERCC6L STARD9 SIPA1L1 SIPA1L3 MAP3K20 GRB2 TSC1 CEP192 MPHOSPH9 CBX4 SIPA1L2 PRAG1 HOMER3 VCL CPEB1	7.38e-07	1102	86	18	int:YWHAH
Interaction	ODF2 interactions	TBC1D31 SIPA1L1 SIPA1L3 PRPF38B CEP192 MPHOSPH9 SIPA1L2	5.10e-06	158	86	7	int:ODF2
Interaction	YWHAG interactions	TICRR ABL1 ABL2 ERCC6L STARD9 SIPA1L1 SIPA1L3 MAP3K20 GRB2 PRPF38B TSC1 CEP192 MPHOSPH9 CBX4 SIPA1L2 PRAG1 VCL	1.76e-05	1248	86	17	int:YWHAG
Interaction	NIN interactions	TBC1D31 UBE2I L3MBTL2 SIPA1L1 SIPA1L3 NDN CEP192 SIPA1L2 CPLANE1	2.25e-05	359	86	9	int:NIN
Interaction	GARNL3 interactions	SIPA1L1 SIPA1L3 SIPA1L2	2.64e-05	14	86	3	int:GARNL3
Interaction	LATS2 interactions	ABL1 OXA1L SIPA1L1 SIPA1L3 TSC1 CEP192 MPHOSPH9 SIPA1L2	3.27e-05	289	86	8	int:LATS2
Interaction	SFN interactions	ABL1 ABL2 ERCC6L SIPA1L1 SIPA1L3 MAP3K20 CEP192 MPHOSPH9 CBX4 CDK1 SIPA1L2 VCL	3.65e-05	692	86	12	int:SFN
Interaction	GKAP1 interactions	L3MBTL2 NDN NPHP4 VCL	4.40e-05	46	86	4	int:GKAP1
Interaction	RB1 interactions	ABL1 L3MBTL1 UBE2I L3MBTL2 GART GRB2 B3GAT1 CBX4 CDK1	4.64e-05	394	86	9	int:RB1
Interaction	RPGRIP1L interactions	SIPA1L1 SIPA1L3 CEP192 MPHOSPH9 SIPA1L2 CPLANE1 NPHP4	5.01e-05	225	86	7	int:RPGRIP1L
Interaction	RALGAPA2 interactions	SIPA1L1 SIPA1L3 SIPA1L2 NPHP4	5.21e-05	48	86	4	int:RALGAPA2
Interaction	MIA3 interactions	LENG8 DNAJC16 B3GAT1 SCFD1 TMEM87A HOMER3 NXPH3	5.91e-05	231	86	7	int:MIA3
Interaction	YWHAQ interactions	TICRR ABL1 ABL2 STARD9 SIPA1L1 SIPA1L3 MAP3K20 GRB2 TSC1 CEP192 MPHOSPH9 CBX4 SIPA1L2 ITGB4 VCL	7.03e-05	1118	86	15	int:YWHAQ
Interaction	FBF1 interactions	GRB2 TSC1 CEP192 SCFD1 VCL TASOR2	9.17e-05	171	86	6	int:FBF1
Interaction	YWHAB interactions	TICRR ABL1 ABL2 STARD9 SIPA1L1 SIPA1L3 MAP3K20 GRB2 TSC1 CEP192 MPHOSPH9 CBX4 SIPA1L2 ITGB4	9.35e-05	1014	86	14	int:YWHAB
Interaction	POLD1 interactions	ATR SIPA1L1 CHD1 CEP192 CBX4 CDK1 TOP1 VCL	9.61e-05	337	86	8	int:POLD1
Interaction	LATS1 interactions	UBE2I L3MBTL2 SIPA1L1 SIPA1L3 CEP192 MPHOSPH9 CDK1 SIPA1L2 NPHP4	1.08e-04	440	86	9	int:LATS1
Interaction	CEP63 interactions	TBC1D31 PCNX4 SIPA1L1 CEP192 MPHOSPH9 CDK1	1.18e-04	179	86	6	int:CEP63
Interaction	FGFR4 interactions	ABL2 GRB2 TSC1 CEP192 CDK1 SCFD1 TMEM87A NXPH3 VCL	1.46e-04	458	86	9	int:FGFR4
Interaction	CNTRL interactions	TBC1D31 PRPF38B TSC1 CEP192 MPHOSPH9 NPHP4	1.78e-04	193	86	6	int:CNTRL
Interaction	NEK4 interactions	ABCA12 STARD9 SMCHD1 ADGRB1 CDK1 NPHP4 FAM186B ITGB4 HSPA6 TOP1	1.84e-04	582	86	10	int:NEK4
Interaction	VTI1A interactions	B3GAT1 SCFD1 CLEC12A B4GALT5	1.93e-04	67	86	4	int:VTI1A
Interaction	UHRF2 interactions	UBE2I ATR SMCHD1 CDK1 CHAMP1 TASOR2	2.16e-04	200	86	6	int:UHRF2
GeneFamily	SH2 domain containing	BMX ABL1 ABL2 GRB2	1.73e-04	101	50	4	741
GeneFamily	Sterile alpha motif domain containing\|MBT domain containing	L3MBTL1 L3MBTL2	2.67e-04	9	50	2	1263
GeneFamily	PDZ domain containing	SHANK2 SIPA1L1 SIPA1L3 SIPA1L2	8.19e-04	152	50	4	1220
ToppCell	LPS-antiTNF-Endothelial-Endothelial-FOXM1\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TICRR MMS22L TBC1D31 ERCC6L MPHOSPH9 CDK1	1.07e-06	163	91	6	5285318c52aa31c9b22dc2ffff078e32e408604d
ToppCell	3'-GW_trimst-1-SmallIntestine-Mesenchymal-myocytic-myofibroblast_(RSPO2+)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NRXN3 TBC1D31 ADGRB1 SIPA1L2 VCL	1.13e-05	143	91	5	39060dc1d87505a16e2df95140087c731f099570
ToppCell	PND14-Immune-Immune_Myeloid-Dendritic\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MMS22L ERCC6L MPHOSPH9 CDK1 SIPA1L2	2.45e-05	168	91	5	9b8a74abb83c64f0b5829dcb4275f722c82b45dc
ToppCell	PND14-Immune-Immune_Myeloid-Dendritic-cDC1\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MMS22L ERCC6L MPHOSPH9 CDK1 SIPA1L2	2.45e-05	168	91	5	4b152b8d0f4a66faf664dfacb7914b18d60ce64a
ToppCell	PND14-Immune-Immune_Myeloid-Dendritic-cDC1-cDC1_G2M\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MMS22L ERCC6L MPHOSPH9 CDK1 SIPA1L2	2.45e-05	168	91	5	c3169ad8f4130ef18777ed86770bb722ffb5db85
ToppCell	LPS-IL1RA+antiTNF-Endothelial-Endothelial-FOXM1\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TICRR MMS22L TBC1D31 ERCC6L CDK1	2.52e-05	169	91	5	e0607af8ae8609d43e26ff2a2cab92650bfcd5b7
ToppCell	facs-Lung-3m-Hematologic-lymphocytic-CD4-positive,_alpha-beta_T_cell-CD4-positive,_alpha-beta_T_cell_l21\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	L3MBTL2 RBM19 CEP192 CDK1 PRAG1	2.67e-05	171	91	5	f1fdc0ec3399ed6955976d02be7e5fc329a64276
ToppCell	wk_20-22-Epithelial-Proximal_epithelial-Deuterosomal\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	CCDC30 PNMA8A WFDC6 CDK1 CCDC171	2.67e-05	171	91	5	52aec5f6677fe2f7a36fb5b18117a4cffaeff58f
ToppCell	droplet-Liver-Npc-18m-Myeloid-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TBC1D31 GRB2 PKD1L2 CHAMP1 CLEC12A	2.82e-05	173	91	5	9ba55e21d1037ec3150d77895e52f0b051df65da
ToppCell	3'-Distal_airway-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Deuterosomal-Deuterosomal_L.0.3.4.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ERCC6L PNMA8A WFDC6 CDK1 CCDC171	2.90e-05	174	91	5	0227fea1678baa9168bd47c3b4aacb2592bb5867
ToppCell	3'-Distal_airway-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ERCC6L PNMA8A WFDC6 CDK1 CCDC171	2.90e-05	174	91	5	c2f8c59fca5f1ff6ffa6dc8cfce62da4b19fe9b3
ToppCell	3'-Distal_airway-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Deuterosomal\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ERCC6L PNMA8A WFDC6 CDK1 CCDC171	2.90e-05	174	91	5	84024c04b0ce9f7068677d2d99ede56882b7dbd2
ToppCell	LPS-IL1RA-Endothelial-Endothelial-FOXM1\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TICRR MMS22L TBC1D31 ERCC6L CDK1	3.41e-05	180	91	5	334e2b1f6eb7d4ece20b1c7b02107863f913237f
ToppCell	TCGA-Breast-Primary_Tumor-Breast_Carcinoma-Infiltrating_Ductal_Carcinoma-5\|TCGA-Breast / Sample_Type by Project: Shred V9	ERCC6L ABCA12 WSB2 CDK1 TOP1	3.60e-05	182	91	5	9e48d5b634603bc7a8d29290202a311457678328
ToppCell	TCGA-Liver-Primary_Tumor-Hepatocellular_Carcinoma-Hepatocellular_Carcinoma-5\|TCGA-Liver / Sample_Type by Project: Shred V9	TICRR MMS22L TBC1D31 ERCC6L CDK1	3.69e-05	183	91	5	f604a8b62c7088fad8365dbf8d910fc980bd3ba8
ToppCell	15-Trachea-Epithelial-Multiciliated_precursor\|Trachea / Age, Tissue, Lineage and Cell class	ERCC6L PNMA8A WFDC6 CDK1 CCDC171	3.89e-05	185	91	5	9a8b8360d99375b726ca8e3c9a3f9b08919892d7
ToppCell	facs-Skin-Anagen-3m-Epithelial-actively_dividing_stem_cell\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TICRR MMS22L ERCC6L MPHOSPH9 CDK1	4.31e-05	189	91	5	bfa3ed1360991a3e32fad133017c413f8adc1eba
ToppCell	facs-Skin-Anagen-3m-Epithelial-keratinocyte_stem_cell\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TICRR MMS22L ERCC6L MPHOSPH9 CDK1	4.31e-05	189	91	5	96f10c63656e446b4bb712f012e91ae986f8c2d0
ToppCell	Control-Endothelial-Endothelial-FOXM1\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TICRR MMS22L TBC1D31 ERCC6L CDK1	4.31e-05	189	91	5	1e1499b062d9c647c8f38b0c4e0d871d159be5dd
ToppCell	human_hepatoblastoma-Tumor_cells-T1\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	TICRR MMS22L TBC1D31 CEP192 MPHOSPH9	4.76e-05	193	91	5	4b9fa2a4424f8abe63fa7bee78db93dda04ab15f
ToppCell	human_hepatoblastoma-Tumor_cells-T9\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	CHD1 CBX4 PRAG1 HSPA6 TOP1	5.50e-05	199	91	5	e9c83555d2197b740797a9f33b64f8f7a7ba1ee2
ToppCell	Control_saline-Epithelial_alveolar-AT_1-Differentiating_AT2\|Control_saline / Treatment groups by lineage, cell group, cell type	SLC6A6 MMS22L NRXN3 PCNX4 TMEM87A	5.63e-05	200	91	5	eac33be484dc443794e66e473f03e98406c2983e
Disease	Large cell carcinoma of lung	BMX ABL1 ATR	1.15e-04	32	87	3	C0345958
Disease	vestibular neuronitis	SLC30A8 ANKRD30A	2.38e-04	8	87	2	EFO_0007537
Disease	breast carcinoma	ANO9 NRXN3 L3MBTL2 CCDC30 SKIDA1 SLC30A8 ANKRD30A CEP192 GREB1 TASOR2	8.33e-04	1019	87	10	EFO_0000305
Disease	serum IgE measurement	CCDC195 SIPA1L2 IL4R	9.06e-04	64	87	3	EFO_0004579
Disease	focal segmental glomerulosclerosis	CCDC30 GRB2	1.00e-03	16	87	2	EFO_0004236
Disease	autism spectrum disorder (implicated_via_orthology)	NRXN3 SHANK2 TSC1 CHD1	1.08e-03	152	87	4	DOID:0060041 (implicated_via_orthology)
Disease	bipolar disorder, sex interaction measurement	ADGRB1 SIPA1L2	1.28e-03	18	87	2	EFO_0008343, MONDO_0004985
Disease	interleukin-2 receptor subunit alpha measurement	PRPF38B TASOR2	1.74e-03	21	87	2	EFO_0010587
Disease	breast cancer (is_marker_for)	LETMD1 L3MBTL1 TSC1 CDK1	2.22e-03	185	87	4	DOID:1612 (is_marker_for)
Disease	unipolar depression, response to selective serotonin reuptake inhibitor	CYP2D7 CBX4	2.27e-03	24	87	2	EFO_0003761, EFO_0005658
Disease	isthmus cingulate cortex volume measurement	CYP2D7 LGI2	2.67e-03	26	87	2	EFO_0010310

Protein segments in the cluster

Peptide	Gene	Start	Entry
GKVVGWKTVFDPHRP	B3GAT1	236	Q9P2W7
AFIHSTGTVWNPPKK	CPED1	286	A4D0V7
AHAGAKFPIKWTAPE	ABL2	441	P42684
KAHGTPTWVKKELEP	ADGRB1	1536	O14514
KWLGSRKSKPHRESG	DNAH10OS	116	P0CZ25
PSSGMDPKSKRHLWK	ABCA12	2416	Q86UK0
GTKFPVKWSAPEVFH	BMX	571	P51813
QWTSGIHKDKDKPPS	CCDC171	436	Q6TFL3
KETSEKFTWPAKGRP	ANKRD30A	366	Q9BXX3
PKKWERPVAESLGHK	FAM186B	426	Q8IYM0
FPLHKGEGRLKKTWA	ANO9	151	A1A5B4
FSKDPTIKLGGHWKP	B4GALT5	141	O43286
AKPPKVDGAEFWKSS	CHD1	76	O14646
VPPFISREWKGHKEK	CFAP91	96	Q7Z4T9
GDPAKPRAWSKHAQK	RBM19	81	Q9Y4C8
HESPPKKKAVAWVSA	PNMA8A	341	Q86V59
AKDSIPRSHWKKTPV	ENTPD5	111	O75356
AWGAPRSSKLHLSPK	LETMD1	36	Q6P1Q0
SGPPKKRHKGWSPES	GREB1	306	Q4ZG55
VPPRTIHAKFTDWKG	L3MBTL2	281	Q969R5
PHPWKQVKGRIYSKF	MMS22L	501	Q6ZRQ5
SPKKKRWEAASSLHP	LENG8	351	Q96PV6
SAVNDPWKSGKSHPK	CCDC195	96	A0A1B0GUA6
PWKSGKSHPKSGILE	CCDC195	101	A0A1B0GUA6
PATKRNWIPAGKHAL	HOMER3	21	Q9NSC5
KDLPSGPEKHFSWKE	PCNX4	341	Q63HM2
AGWFEKTGHKLQPPK	L3MBTL1	361	Q9Y468
AHAPKWESKDFRPNK	NRXN3	1451	Q9Y4C0
KLAREWHPDKNKDPG	DNAJC16	51	Q9Y2G8
KYPSHTKASPVDSWK	MPHOSPH9	356	Q99550
PPREGFLESFKKGWK	OXA1L	356	Q15070
KPHPWFFGKIPRAKA	GRB2	56	P62993
KAAGSRKIHFNWLPP	ITGB4	1136	P16144
LKKGRFWITPDPYHK	MDGA2	331	Q7Z553
KFPWGPRAHAETTKM	MAGEA13P	266	A6NCF6
VSPWKSSAVPTKHAK	NPHP4	1091	O75161
KPKAARSGPWKDSAY	PKD1L2	1736	Q7Z442
KWPTSGQLFLGHPKA	FUCA2	401	Q9BTY2
KGVKAPHSSRPRAWK	GUCA1ANB	36	X6R8D5
PLVEWSKPVKGHSKA	ATR	2561	Q13535
WKGSFKPSEHVKPRA	IL4R	111	P24394
PWPHGTATFTIQKKA	CPLANE1	3046	Q9H799
ITSKHASPDKWNDKP	CHAMP1	81	Q96JM3
KSHPPDKWAQGAGAK	CBX4	191	O00257
WHRGKLASLPPTKKQ	CCDC30	641	Q5VVM6
HAGAKFPIKWTAPES	ABL1	396	P00519
GWAASKSKEKVPARP	ADGRF2	91	Q8IZF7
GGWTKVEYRKKPHRP	MAP3K20	766	Q9NYL2
KPDFRWSKDPSSKSG	CEP192	1131	Q8TEP8
SLSVEWPGKDGKHPR	CPEB1	336	Q9BZB8
HWPFRVVSEGGKPKV	HSPA6	91	P17066
KKHQFKWPSGHPRFR	HINFP	366	Q9BQA5
KWTPGMRVKTFHGPS	ERCC6L	166	Q2NKX8
GKVDASWDPKSPFKQ	LRRC72	201	A6NJI9
PPSAKVKKIFGWGDF	NXPH3	91	O95157
DPFKATGKPHTLWVA	XAB2	386	Q9HCS7
AFPTKKKWESGHCLK	TATDN1	241	Q6P1N9
GKPPQREKWSSKIDF	SLC6A6	36	P31641
KKTLPDWKRSLPHFR	SMCHD1	1781	A6NHR9
SGKIWHRKPSPATRD	TBC1D31	11	Q96DN5
WNKSSKKFVPHGDIP	LGI2	401	Q8N0V4
HAPKWESKDFRPNKV	NRXN3	446	Q9HDB5
RAAAASPRPGFWKDK	SKIDA1	121	Q1XH10
RSGPGKEKVAPLWHS	SIPA1L1	1351	O43166
TKWHGPPSKVLGSYK	SIPA1L2	1181	Q9P2F8
FSKQPVRNKHPTGWK	SIPA1L3	1446	O60292
RGPWIHESKHPAFAK	SEM1	41	Q6ZVN7
HGKAVKTFWTEYKPP	STARD9	1021	Q9P2P6
INKRSGPKRGKHAWT	SSX1	151	Q16384
KPFTTKPVHLWTKPD	SHANK2	1776	Q9UPX8
FPKWKPGSLASHVKN	CDK1	241	P06493
KFGEKAPPAPSHVWR	CLEC12A	26	Q5QGZ9
LKDEAVWKKPFRFHP	CYP2D7	421	A0A087X1C5
LFWGSKHFWPEVPKK	TNMD	46	Q9H2S6
AWPPYHTGGTIKKTK	WFDC6	86	Q9BQY6
KPPSKRLTFGWHRAE	SLC30A8	126	Q8IWU4
KLPLPSKSVDWTHFG	TSC1	666	Q92574
PKHSGKTTPDIIKDW	TICRR	1671	Q7Z2Z1
WRKDHPFGFVAVPTK	UBE2I	16	P63279
INKASGPKRGKHAWT	SSX9P	151	Q7RTT3
FKVTHVEPWEKGSRK	PRPF38B	91	Q5VTL8
HDEARKWSSKPGIPA	VCL	906	P18206
PVDKFWQKHKGSPFP	SCFD1	321	Q8WVM8
PLEKAFKGSGHWLPA	PRAG1	881	Q86YV5
RHGIPTAQWKAFTKP	GART	116	P22102
TSLPPGHWTAAVKKE	TASOR2	1891	Q5VWN6
KFHKACPKWYPSRVG	TECRL	91	Q5HYJ1
AELKPGRPHQFDWKS	WSB2	11	Q9NYS7
WKRHPERGKPEKVHS	ZNF438	701	Q7Z4V0
TVEFPSSPGTKKWHA	ZP2	61	Q05996
PPGHKWKEVRHDNKV	TOP1	396	P11387
KGFPSQCHPERKWKV	ZNF248	71	Q8NDW4
AADRSKWHIPIPSGK	TMEM87A	36	Q8NBN3
KKSPAWKHFFISPRD	ZBED4	116	O75132
PWKKHSTFGDVRKLI	NDN	221	Q99608