Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	EGF	SELL FRAS1 F12 SVEP1 GPR179 TMEFF2 ITGBL1 JAG1	7.58e-05	235	110	8	SM00181
Domain	FAM53	FAM53C FAM53B	1.03e-04	3	110	2	IPR029356
Domain	FAM53	FAM53C FAM53B	1.03e-04	3	110	2	PF15242
Domain	VWC_out	FRAS1 VWF JAG1	1.80e-04	19	110	3	SM00215
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	FAM193B FRAS1 SH2B3 KALRN ITGA5 GTF2IRD1 CIT TBC1D17 AATK PLEKHM2 FLCN TNKS1BP1 GNAZ ZNF839 PLXNA1 TOP3A	5.98e-07	1105	113	16	35748872
Pubmed	WNK3 interacts with NCC.	SLC12A3 WNK3	1.05e-05	2	113	2	27378340
Pubmed	Scatter factor/hepatocyte growth factor is essential for liver development.	HGF VWF	1.05e-05	2	113	2	7854452
Pubmed	Human Jagged 1 mutants cause liver defect in Alagille syndrome by overexpression of hepatocyte growth factor.	HGF JAG1	1.05e-05	2	113	2	16403414
Pubmed	The thiazide-sensitive Na-Cl cotransporter is regulated by a WNK kinase signaling complex.	SLC12A3 WNK3	3.13e-05	3	113	2	17975670
Pubmed	Renal and brain isoforms of WNK3 have opposite effects on NCCT expression.	SLC12A3 WNK3	3.13e-05	3	113	2	19470686
Pubmed	Activation of AMP-activated protein kinase by MAPO1 and FLCN induces apoptosis triggered by alkylated base mismatch in DNA.	FNIP2 FLCN	3.13e-05	3	113	2	22209521
Pubmed	Nutrient-induced FNIP degradation by SCFβ-TRCP regulates FLCN complex localization and promotes renal cancer progression.	FNIP2 FLCN	3.13e-05	3	113	2	28039480
Pubmed	Mouse venous thrombosis upon silencing of anticoagulants depends on tissue factor and platelets, not FXII or neutrophils.	VWF F12	3.13e-05	3	113	2	30898865
Pubmed	Loss of FLCN-FNIP1/2 induces a non-canonical interferon response in human renal tubular epithelial cells.	FNIP2 FLCN	3.13e-05	3	113	2	33459596
Pubmed	DYRK1A regulates the recruitment of 53BP1 to the sites of DNA damage in part through interaction with RNF169.	JCAD FAM53C FAM53B TNKS1BP1 CNOT2	5.07e-05	122	113	5	30773093
Pubmed	Adhesion dependent release of hepatocyte growth factor and interleukin-1 receptor antagonist from human blood granulocytes and monocytes: evidence for the involvement of plasma IgG, complement C3 and beta2 integrin.	HGF IL1RN	6.25e-05	4	113	2	15241561
Pubmed	Interaction of folliculin (Birt-Hogg-Dubé gene product) with a novel Fnip1-like (FnipL/Fnip2) protein.	FNIP2 FLCN	6.25e-05	4	113	2	18663353
Pubmed	Accumulation of gene polymorphisms related to plaque disruption and thrombosis is associated with cerebral infarction in subjects with type 2 diabetes.	VWF F12	6.25e-05	4	113	2	19933990
Pubmed	Folliculin variants linked to Birt-Hogg-Dubé syndrome are targeted for proteasomal degradation.	FNIP2 FLCN	6.25e-05	4	113	2	33137092
Pubmed	Intermolecular Interaction between Anchoring Subunits Specify Subcellular Targeting and Function of RGS Proteins in Retina ON-Bipolar Neurons.	RGS11 GPR179	6.25e-05	4	113	2	26961947
Pubmed	Bone marrow dendritic cells regulate hematopoietic stem/progenitor cell trafficking.	ZBTB46 SIGLEC1	6.25e-05	4	113	2	31039135
Pubmed	Folliculin-interacting proteins Fnip1 and Fnip2 play critical roles in kidney tumor suppression in cooperation with Flcn.	FNIP2 FLCN	6.25e-05	4	113	2	25775561
Pubmed	Impaired platelet aggregation and sustained bleeding in mice lacking the fibrinogen motif bound by integrin alpha IIb beta 3.	VWF ITGA5	6.25e-05	4	113	2	8918453
Pubmed	A new subfamily of structurally related human F-box proteins.	FBXO17 FBXO27	1.04e-04	5	113	2	12383498
Pubmed	GPR158/179 regulate G protein signaling by controlling localization and activity of the RGS7 complexes.	RGS11 GPR179	1.04e-04	5	113	2	22689652
Pubmed	Functional TFEB activation characterizes multiple models of renal cystic disease and loss of polycystin-1.	FNIP2 FLCN	1.04e-04	5	113	2	36794754
Pubmed	Inactivation of the FLCN tumor suppressor gene induces TFE3 transcriptional activity by increasing its nuclear localization.	FNIP2 FLCN	1.04e-04	5	113	2	21209915
Pubmed	Identification and characterization of a novel folliculin-interacting protein FNIP2.	FNIP2 FLCN	1.56e-04	6	113	2	18403135
Pubmed	An IL-4 signalling axis in bone marrow drives pro-tumorigenic myelopoiesis.	ZBTB46 SIGLEC1	1.56e-04	6	113	2	38057662
Pubmed	Differential onset of expression of alpha 7 and beta 1D integrins during mouse heart and skeletal muscle development.	VWF ITGA5	1.56e-04	6	113	2	9686317
Pubmed	GPR179 is required for high sensitivity of the mGluR6 signaling cascade in depolarizing bipolar cells.	RGS11 GPR179	1.56e-04	6	113	2	24790204
Pubmed	WNK3 kinase is a positive regulator of NKCC2 and NCC, renal cation-Cl- cotransporters required for normal blood pressure homeostasis.	SLC12A3 WNK3	1.56e-04	6	113	2	16275913
Pubmed	Beta1 integrin expression on endothelial cells is required for angiogenesis but not for vasculogenesis.	VWF ITGA5	1.56e-04	6	113	2	18058911
Pubmed	LRIT3 is essential to localize TRPM1 to the dendritic tips of depolarizing bipolar cells and may play a role in cone synapse formation.	RGS11 GPR179	2.17e-04	7	113	2	25997951
Pubmed	Fluid flow-induced left-right asymmetric decay of Dand5 mRNA in the mouse embryo requires a Bicc1-Ccr4 RNA degradation complex.	PKD2 NOTO	2.17e-04	7	113	2	34210974
Pubmed	Tissue Resident CCR2- and CCR2+ Cardiac Macrophages Differentially Orchestrate Monocyte Recruitment and Fate Specification Following Myocardial Injury.	ZBTB46 SIGLEC1	2.17e-04	7	113	2	30582448
Pubmed	Bridging expressed sequence alignments through targeted cDNA sequencing.	DIP2B CARMIL3	2.89e-04	8	113	2	15028280
Pubmed	Endothelial expression of the Notch ligand Jagged1 is required for vascular smooth muscle development.	VWF JAG1	2.89e-04	8	113	2	18245384
Pubmed	Diversity in tissue expression, substrate binding, and SCF complex formation for a lectin family of ubiquitin ligases.	FBXO17 FBXO27	2.89e-04	8	113	2	18203720
Pubmed	Targeting of the pulmonary capillary vascular niche promotes lung alveolar repair and ameliorates fibrosis.	ACKR3 JAG1	2.89e-04	8	113	2	26779814
Pubmed	Similar effects of all WNK3 variants on SLC12 cotransporters.	SLC12A3 WNK3	2.89e-04	8	113	2	21613606
Pubmed	Long noncoding RNA Hoxb3os is dysregulated in autosomal dominant polycystic kidney disease and regulates mTOR signaling.	HOXB2 PKD2	2.89e-04	8	113	2	29716997
Pubmed	Skp1 stabilizes the conformation of F-box proteins.	FBXO17 FBXO27	2.89e-04	8	113	2	21640084
Pubmed	Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.	ODAD2 ITGBL1 ZBTB46 AATK FAM218A CD53 RASEF FAM53B CSMD1 IL1RN	3.32e-04	814	113	10	23251661
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	DIP2B NCAM2 GTF2IRD1 TMEFF2 TASOR2 ZBTB46 ATP11B ACKR3 PKD2 RASEF GNAZ CSMD1 ZNF839 VPS13B	3.42e-04	1489	113	14	28611215
Pubmed	Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	FNIP2 JCAD DIP2B FRAS1	3.65e-04	103	113	4	10819331
Pubmed	Microfibril-associated glycoprotein-2 interacts with fibrillin-1 and fibrillin-2 suggesting a role for MAGP-2 in elastic fiber assembly.	VWF JAG1	3.71e-04	9	113	2	12122015
Pubmed	Characterization of new members of the human type II keratin gene family and a general evaluation of the keratin gene domain on chromosome 12q13.13.	KRT84 KRT80	3.71e-04	9	113	2	15737194
Pubmed	Identification of a tankyrase-binding motif shared by IRAP, TAB182, and human TRF1 but not mouse TRF1. NuMA contains this RXXPDG motif and is a novel tankyrase partner.	HOXB2 TNKS1BP1	3.71e-04	9	113	2	12080061
Pubmed	Single-cell analysis of murine long-term hematopoietic stem cells reveals distinct patterns of gene expression during fetal migration.	ITGA5 SLAMF1	3.71e-04	9	113	2	22276210
Pubmed	Structural basis for FLCN RagC GAP activation in MiT-TFE substrate-selective mTORC1 regulation.	FNIP2 FLCN	4.63e-04	10	113	2	36103527
Pubmed	The contribution of genetic factors to thrombotic and bleeding outcomes in coronary patients randomised to IIb/IIIa antagonists.	VWF IL1RN	4.63e-04	10	113	2	12082590
Pubmed	Hnf4a deletion in the mouse kidney phenocopies Fanconi renotubular syndrome.	SLC12A3 JAG1	4.63e-04	10	113	2	30046000
Pubmed	Haploinsufficiency of the mouse Forkhead Box f1 gene causes defects in gall bladder development.	HGF ITGA5	4.63e-04	10	113	2	11809759
Pubmed	A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.	FOXJ2 GTF2IRD1 ZBTB1 OTP PEX2 CNOT2 PLXNA1 ZMYM3 TOP3A	5.25e-04	709	113	9	22988430
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	FRAS1 TNFSF9 NAGA ITGA5 SPAG5 ACKR3 PKD2 FLCN TNKS1BP1 FUCA2 PLXNA1 DSE	5.45e-04	1201	113	12	35696571
Pubmed	Suppression of Notch signalling by the COUP-TFII transcription factor regulates vein identity.	VWF JAG1	5.65e-04	11	113	2	15875024
Pubmed	The Auxiliary Calcium Channel Subunit α2δ4 Is Required for Axonal Elaboration, Synaptic Transmission, and Wiring of Rod Photoreceptors.	RGS11 GPR179	5.65e-04	11	113	2	28262416
Pubmed	Depletion of mammalian CCR4b deadenylase triggers elevation of the p27Kip1 mRNA level and impairs cell growth.	TNKS1BP1 CNOT2	6.76e-04	12	113	2	17452450
Pubmed	Notch signaling promotes nephrogenesis by downregulating Six2.	SLC12A3 JAG1	6.76e-04	12	113	2	27633993
Pubmed	Human Ccr4-Not complexes contain variable deadenylase subunits.	TNKS1BP1 CNOT2	6.76e-04	12	113	2	19558367
Pubmed	Expression of Notch signaling pathway genes in mouse embryos lacking beta4galactosyltransferase-1.	JAG1 MESP2	6.76e-04	12	113	2	16412699
Pubmed	Reconstitution of recombinant human CCR4-NOT reveals molecular insights into regulated deadenylation.	TNKS1BP1 CNOT2	6.76e-04	12	113	2	31320642
Pubmed	Compartmentalised expression of Delta-like 1 in epithelial somites is required for the formation of intervertebral joints.	JAG1 MESP2	6.76e-04	12	113	2	17572911
Pubmed	Identification of novel genetic Loci associated with thyroid peroxidase antibodies and clinical thyroid disease.	SH2B3 KALRN	7.97e-04	13	113	2	24586183
Pubmed	Inhibition of notch1-dependent cardiomyogenesis leads to a dilated myopathy in the neonatal heart.	VWF JAG1	7.97e-04	13	113	2	20558824
Pubmed	Post-developmental plasticity of the primary rod pathway allows restoration of visually guided behaviors.	RGS11 GPR179	7.97e-04	13	113	2	36179691
Pubmed	Tbx6 controls left-right asymmetry through regulation of Gdf1.	PKD2 NOTO	7.97e-04	13	113	2	29650695
Pubmed	β3GnT2 maintains adenylyl cyclase-3 signaling and axon guidance molecule expression in the olfactory epithelium.	NCAM2 PLXNA1	9.28e-04	14	113	2	21525298
Pubmed	FLCN, a novel autophagy component, interacts with GABARAP and is regulated by ULK1 phosphorylation.	FNIP2 FLCN	9.28e-04	14	113	2	25126726
Pubmed	Molecular determinants of epithelial mesenchymal transition in mouse placenta and trophoblast stem cell.	ITGA5 JAG1	9.28e-04	14	113	2	37414855
Pubmed	Hoxb3 Regulates Jag1 Expression in Pharyngeal Epithelium and Affects Interaction With Neural Crest Cells.	HOXB2 JAG1	9.28e-04	14	113	2	33505317
Pubmed	Splenic Dendritic Cells Survey Red Blood Cells for Missing Self-CD47 to Trigger Adaptive Immune Responses.	ZBTB46 SIGLEC1	9.28e-04	14	113	2	26453377
Pubmed	A genome-wide association study identifies protein quantitative trait loci (pQTLs).	ANGPTL6 STARD9 IL1RN	1.05e-03	61	113	3	18464913
Pubmed	β-catenin regulates the formation of multiple nephron segments in the mouse kidney.	SLC12A3 JAG1	1.07e-03	15	113	2	31685872
Pubmed	Interaction between Notch signalling and Lunatic fringe during somite boundary formation in the mouse.	JAG1 MESP2	1.07e-03	15	113	2	10330372
Pubmed	CXCL12 defines lung endothelial heterogeneity and promotes distal vascular growth.	VWF ACKR3	1.22e-03	16	113	2	36239312
Pubmed	Allocation of paraventricular and supraoptic neurons requires Sim1 function: a role for a Sim1 downstream gene PlexinC1.	OTP PLXNA1	1.22e-03	16	113	2	17356169
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	DIP2B FRAS1 GMIP TBC1D17 SPAG5 CASKIN2 TOP3A SLC27A4	1.31e-03	650	113	8	38777146
Pubmed	C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.	FNIP2 ITGA5 PLEKHM2 FLCN PLXNA1 VPS13B SLC27A4	1.33e-03	504	113	7	34432599
Pubmed	Sall1 balances self-renewal and differentiation of renal progenitor cells.	FRAS1 NCAM2 JAG1	1.38e-03	67	113	3	24550112
Pubmed	Variation in immune response genes and chronic Q fever. Concepts: preliminary test with post-Q fever fatigue syndrome.	SELL IL1RN	1.38e-03	17	113	2	12595908
Pubmed	Structural basis and sequence rules for substrate recognition by Tankyrase explain the basis for cherubism disease.	HOXB2 TNKS1BP1	1.38e-03	17	113	2	22153077
Pubmed	Association analyses identify three susceptibility Loci for vitiligo in the Chinese Han population.	PMEL TREH	1.38e-03	17	113	2	22951725
Pubmed	Conserved and Divergent Features of Human and Mouse Kidney Organogenesis.	SLC12A3 JAG1	1.38e-03	17	113	2	29449453
Pubmed	Notch is required for the formation of all nephron segments and primes nephron progenitors for differentiation.	SLC12A3 JAG1	1.55e-03	18	113	2	29113990
Pubmed	PlexinD1 and semaphorin signaling are required in endothelial cells for cardiovascular development.	VWF PLXNA1	1.73e-03	19	113	2	15239958
Pubmed	Generation of Distal Renal Segments Involves a Unique Population of Aqp2 + Progenitor Cells.	SLC12A3 JAG1	1.73e-03	19	113	2	34667084
Pubmed	A Notch-dependent molecular circuitry initiates pancreatic endocrine and ductal cell differentiation.	JAG1 PKD2	1.73e-03	19	113	2	22675211
Pubmed	Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.	GTF2IRD1 TMEFF2 ITGBL1 CSMD1 PLXNA1	1.78e-03	265	113	5	19240061
Pubmed	RNF219 attenuates global mRNA decay through inhibition of CCR4-NOT complex-mediated deadenylation.	TNKS1BP1 CNOT2	1.91e-03	20	113	2	34887419
Pubmed	The transcriptional repressor Blimp1/Prdm1 regulates postnatal reprogramming of intestinal enterocytes.	NAGA TREH	2.11e-03	21	113	2	21670299
Pubmed	Modulation of CD4 lateral interaction with lymphocyte surface molecules induced by HIV-1 gp120.	SELL CD53	2.11e-03	21	113	2	7539755
Pubmed	The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding.	FNIP2 FLCN	2.11e-03	21	113	2	27353360
Pubmed	Nonmuscle Myosin II Regulates the Morphogenesis of Metanephric Mesenchyme-Derived Immature Nephrons.	SLC12A3 JAG1	2.11e-03	21	113	2	25168025
Pubmed	Inactivation of Notch signaling in the renal collecting duct causes nephrogenic diabetes insipidus in mice.	SLC12A3 JAG1	2.11e-03	21	113	2	19855135
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	FNIP2 FRAS1 PLEKHM2 STARD9 VPS13B ZMYM3	2.19e-03	407	113	6	12693553
Pubmed	Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.	FAM193B VWF KALRN CARMIL3 ATXN1L SVEP1 ATP11B	2.22e-03	552	113	7	10737800
Pubmed	Lipid signatures reflect the function of the murine primary placentation†.	VWF SLC27A4	2.32e-03	22	113	2	34850819
Pubmed	Interaction of antiproliferative protein Tob with the CCR4-NOT deadenylase complex.	TNKS1BP1 CNOT2	2.32e-03	22	113	2	18377426
Pubmed	New gene functions in megakaryopoiesis and platelet formation.	VWF SH2B3 KALRN	2.37e-03	81	113	3	22139419
Pubmed	A proteome-scale map of the SARS-CoV-2-human contactome.	KALRN KRT80 SPAG5 NOTO	2.50e-03	173	113	4	36217029
Pubmed	Msx genes define a population of mural cell precursors required for head blood vessel maturation.	VWF JAG1	2.53e-03	23	113	2	21693521
Pubmed	Hepatocyte nuclear factor 1β controls nephron tubular development.	SLC12A3 JAG1	2.53e-03	23	113	2	23362349
Interaction	KLKB1 interactions	HGF ZBTB1 F12 CNOT2	1.83e-06	17	109	4	int:KLKB1
Cytoband	6q24	EPM2A FUCA2	1.67e-04	8	113	2	6q24
ToppCell	droplet-Kidney-KIDNEY-30m-Epithelial-Epcam____brush_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC6A18 UROC1 GPR179 RUNDC3A TREH ACKR3 PCDHGB4	1.93e-07	162	113	7	de0fde4310a56dc96bfc134c44d104993526d9bc
ToppCell	LPS-antiTNF-Endothelial-Endothelial-Alv_Gen_Intermediate\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	JCAD VWF ITGA5 ZBTB46 MCTP1 CASKIN2 BCAR3	5.29e-07	188	113	7	789d1be574e693d7bdd488f3c72c6df788e47b47
ToppCell	Macrophages-Cryobiopsy_01\|World / lung cells shred on cell class, cell subclass, sample id	ARRDC4 GMIP ITGA5 OVCH1 CD53 IL1RN DSE	5.48e-07	189	113	7	c05b4b565c0ce56dbb45fc9503654a2ec1a7e1e9
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	JCAD VWF KALRN ITGA5 ZBTB46 MCTP1 STARD9	6.09e-07	192	113	7	28eb3a5728e8901bcb5ba12f6b009f41b065fa37
ToppCell	3'-Distal_airway-Immune_Myeloid-Myeloid_macrophage-elicited_macrophage-Monocyte-derived_macrophage-Monocyte-derived_macrophage_L.1.2.3.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SELL ITGA5 SLAMF1 SIGLEC10 CD53 IL1RN DSE	6.53e-07	194	113	7	3ef9e88e66f2f2ae95dcc834ea605c40c60783fc
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-DC-cDC2-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	SELL SH2B3 ITGA5 MCTP1 CD53 SIGLEC1 DSE	6.76e-07	195	113	7	a2fe352682f548001ca2ee056e7a54af10134453
ToppCell	3'-Broncho-tracheal-Immune_Myeloid-Myeloid_macrophage-elicited_macrophage\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FNIP2 SH2B3 SLAMF1 ZBTB1 SIGLEC10 IL1RN DSE	6.99e-07	196	113	7	c2bbb48c4aa979b03cb6f4ce9f351f492977c992
ToppCell	3'-Broncho-tracheal-Immune_Myeloid-Myeloid_macrophage-elicited_macrophage-Monocyte-derived_macrophage\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FNIP2 SH2B3 SLAMF1 ZBTB1 SIGLEC10 IL1RN DSE	6.99e-07	196	113	7	64c2abc0087bf2ae547932377f3662e3be1cc63e
ToppCell	BAL-Mild-Myeloid-MoAM\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FNIP2 OTOA HGF TMEM176A SIGLEC1 IL1RN DSE	7.24e-07	197	113	7	0f40dd3530eb8d02e79b32f942efe3b65b8f6ee6
ToppCell	BAL-Mild-Myeloid-MoAM\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	FNIP2 OTOA HGF TMEM176A SIGLEC1 IL1RN DSE	7.24e-07	197	113	7	a6aa5991d566c28440f7e24a30933e69669064f2
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	JCAD VWF KALRN ITGA5 ZBTB46 CASKIN2 STARD9	7.49e-07	198	113	7	0a172c6d997c7cfbad34b56e80121bd104dee67d
ToppCell	(02)_MMP9/10+-(1)_GFP\|(02)_MMP9/10+ / shred by cell type by condition	FAM193B ARRDC4 ITGA5 ACKR3 JAG1 BCAR3 IL1RN	7.74e-07	199	113	7	448ba982be804007f991d469eca9d885b21ae499
ToppCell	facs-Trachea-24m-Hematologic-myeloid-granulocyte\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SELL ARRDC4 MCTP1 GNAZ IL1RN SLC27A4	3.05e-06	157	113	6	188d2f85babcd4eefe20e7a392d851b2e1185bab
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Hematopoietic-Myeloid-pDC\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SELL TNFSF9 SLC12A3 CD53 SIGLEC1 RELT	5.15e-06	172	113	6	d40a8bd61114b49a5837c836136a13c37c8f7de0
ToppCell	COPD-Endothelial-VE_Venous\|Endothelial / Disease state, Lineage and Cell class	FNIP2 VWF PNLIP TMEM176A MCTP1 LRRN4	6.48e-06	179	113	6	e816dd846a6918ec143b57a380c3a47ed073b66e
ToppCell	10x5'-Lung-Myeloid_Dendritic-migDC\|Lung / Manually curated celltypes from each tissue	ZBTB46 SLC12A3 KCNN1 LRRN4 GNAZ FBXO27	6.68e-06	180	113	6	e9e8992deb0beeee5548910e4616e7c990763d99
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OTOA FRAS1 KALRN NCAM2 ODAD2 CSMD1	7.58e-06	184	113	6	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell__prolif\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	JCAD VWF ITGA5 ZBTB46 STARD9 NOTO	7.58e-06	184	113	6	688428103e8b19f45f2f65d70a0f30c904c8411c
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OTOA FRAS1 KALRN NCAM2 ODAD2 CSMD1	7.58e-06	184	113	6	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OTOA FRAS1 KALRN NCAM2 ODAD2 CSMD1	7.58e-06	184	113	6	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	3'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-elicited_macrophage-Monocyte-derived_macrophage-Monocyte-derived_macrophage_L.1.2.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FNIP2 SH2B3 ZBTB1 SPAG5 IL1RN DSE	7.58e-06	184	113	6	b45b1fdba13c8ed2a04a4fb3b62d8ad92785c768
ToppCell	Control-Endothelial_cells-Endothelial_cells_(other)\|Control / group, cell type (main and fine annotations)	JCAD VWF KALRN ITGA5 ZBTB46 CASKIN2	8.06e-06	186	113	6	c6075fe84226b370c5139066793844ad33ae2db1
ToppCell	Control\|World / Disease state, Lineage and Cell class	FNIP2 SH2B3 AATK SIGLEC10 BCAR3 DSE	8.83e-06	189	113	6	fb8dddd3b901081c6bb9ed6f32dafc5cce5f30be
ToppCell	LPS_only-Endothelial-Endothelial-Vein\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	VWF KALRN ITGA5 SLAMF1 MCTP1 ACKR3	9.66e-06	192	113	6	52acaecd3703166f5ce3b328aff7c82bd142fee4
ToppCell	LPS-antiTNF-Endothelial-Endothelial\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	JCAD VWF ITGA5 ZBTB46 MCTP1 CASKIN2	9.95e-06	193	113	6	02f633b016ab19bfa65bfd0cf32f000549a62148
ToppCell	LPS-antiTNF-Endothelial\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	JCAD VWF ITGA5 ZBTB46 MCTP1 CASKIN2	9.95e-06	193	113	6	5122b1ffba42de190061be34ecdc6176f84e56a3
ToppCell	LPS-IL1RA+antiTNF-Endothelial-Endothelial-Vein\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	VWF KALRN ITGA5 SLAMF1 MCTP1 ACKR3	9.95e-06	193	113	6	7261c1ce30c796b61c6ec58e64a051baa24732ff
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	JCAD VWF KALRN ITGA5 ZBTB46 STARD9	1.02e-05	194	113	6	f76808666fb875fc787751cbfd924d9be20a8192
ToppCell	LPS-IL1RA-Endothelial\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	JCAD VWF ITGA5 ZBTB46 MCTP1 CASKIN2	1.02e-05	194	113	6	43f92b0533e26633dc94cce554045d641ef8fd76
ToppCell	LPS-IL1RA-Endothelial-Endothelial\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	JCAD VWF ITGA5 ZBTB46 MCTP1 CASKIN2	1.02e-05	194	113	6	1d39d968730a7e85b6161c1c8a6bd38afe9bcad7
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	JCAD VWF KALRN ITGA5 ZBTB46 STARD9	1.02e-05	194	113	6	f5706ab6bc803606c4640ddd606617e4e797ccc9
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	JCAD VWF KALRN ITGA5 ZBTB46 STARD9	1.02e-05	194	113	6	a52c5906fce43c2f72cf7e463a3d15cde06431f6
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	VWF KALRN ZBTB46 AATK MCTP1 CD53	1.06e-05	195	113	6	6bdef651cf73d7381e5012d0eb3c809138fb6b92
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	JCAD VWF KALRN ITGA5 ZBTB46 STARD9	1.09e-05	196	113	6	8ad8efb631164b46f0c082572270188e5ead20bf
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	JCAD VWF KALRN ITGA5 ZBTB46 STARD9	1.09e-05	196	113	6	ab7be3858deabbd1fc44e8b9da8ff49a50bf1fb1
ToppCell	BAL-Mild-Myeloid-MoAM-MoAM1\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	FNIP2 OTOA HGF TMEM176A SIGLEC1 IL1RN	1.09e-05	196	113	6	7c8aa5853d7096628e35af665097c0299c329753
ToppCell	3'-Broncho-tracheal-Immune_Myeloid-Myeloid_macrophage-elicited_macrophage-Monocyte-derived_macrophage-Monocyte-derived_macrophage_L.1.2.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FNIP2 SH2B3 ZBTB1 SIGLEC10 IL1RN DSE	1.09e-05	196	113	6	01cea0bb0b938d0986fd2ddae06597b8af1768ee
ToppCell	BAL-Mild-Myeloid-MoAM-MoAM1-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FNIP2 OTOA HGF TMEM176A SIGLEC1 IL1RN	1.09e-05	196	113	6	f60b220ed117bcc33e0f7bbf5b53d3b1422ebaca
ToppCell	BAL-Mild-Myeloid-MoAM-MoAM1-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	FNIP2 OTOA HGF TMEM176A SIGLEC1 IL1RN	1.09e-05	196	113	6	bcd274db4955ea76ca26267a272c7d1929db24f4
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	JCAD VWF KALRN ITGA5 ZBTB46 STARD9	1.09e-05	196	113	6	9606ea7e42f707e69ea891b3521037613b9675f5
ToppCell	NS-moderate-d_07-13-Myeloid\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	FNIP2 TMEM176A ITGA5 CD53 SIGLEC1 DSE	1.09e-05	196	113	6	e5c7ef2f092ad082698f014f9c5ba1ff4d07b93f
ToppCell	BAL-Mild-Myeloid-MoAM-MoAM1\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FNIP2 OTOA HGF TMEM176A SIGLEC1 IL1RN	1.09e-05	196	113	6	80b9139d91dda4de69830d2d443859e047ab5503
ToppCell	Mild_COVID-19-Myeloid-MoAM1\|Mild_COVID-19 / Disease group,lineage and cell class （2021.01.30）	FNIP2 OTOA HGF TMEM176A SIGLEC1 IL1RN	1.09e-05	196	113	6	ea3fbe81b4ecb6ccc8031f6d99da93c9f9f8c1aa
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	JCAD KALRN ITGA5 ZBTB46 MCTP1 STARD9	1.09e-05	196	113	6	145fcf73deba9638b391a1af6c39fa205dc9829f
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	JCAD VWF KALRN ITGA5 ZBTB46 STARD9	1.12e-05	197	113	6	0f467ef58f0c4dcc00b34b7b9639e03fb3ebe780
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Myeloid-Monocytic-Nonclassical_Monocyte-Mono_c4-CD14-CD16\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	SH2B3 NAGA TMEM176A MCTP1 SIGLEC10 RELT	1.12e-05	197	113	6	989eaf7ecef8683e3ec6ec024fd193a2f5861b26
ToppCell	COVID-19-Myeloid-MoAM1,_IL1R2\|COVID-19 / Condition, Lineage and Cell class	FNIP2 TMEM176A SIGLEC10 SIGLEC1 IL1RN DSE	1.12e-05	197	113	6	4a9c61b37c938bb26929593007d713382ae1eb79
ToppCell	5'-Adult-Distal_Rectal-Endothelial-blood_vessel_EC-Mature_arterial_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FNIP2 JCAD VWF ITGA5 MCTP1 JAG1	1.15e-05	198	113	6	8a55589b9244283e4b0b423a4a6d6202e8e0fec9
ToppCell	Bronchus_Control_(B.)-Immune-TX-MoAM-3\|Bronchus_Control_(B.) / Sample group, Lineage and Cell type	FNIP2 OTOA TNFSF9 ITGA5 PLEKHM2 IL1RN	1.15e-05	198	113	6	1d92b09aeb03a95fa9e221813002045c4f41dd24
ToppCell	distal-2-Hematologic-OLR1+_Classical_Monocyte\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	SELL SLAMF1 SIGLEC10 CD53 IL1RN DSE	1.15e-05	198	113	6	43179d92e45b14f6f3d63949a9d88c2c7531f7d1
ToppCell	distal-3-Hematologic-Myeloid_Dendritic_Type_1\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	ZBTB46 SLC12A3 SIGLEC10 KCNN1 GNAZ FBXO27	1.15e-05	198	113	6	b21227c7366ef79b36048509a91d2d35fd5e4956
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Myeloid-Macrophage-macrophage,_alveolar-Macro_c2-CCL3L1\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	FNIP2 SELL ITGA5 CD53 SIGLEC1 DSE	1.18e-05	199	113	6	d3f77acb36ac7c56a47ca98b695f46ae5b9ecd12
ToppCell	Tracheal-10x5prime-Endothelial-Endothelia_vascular-VE_pulmonary_arterial\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	FNIP2 VWF ITGA5 MCTP1 CASKIN2 TREH	1.18e-05	199	113	6	9735a1dc10910f02f1106b20ae5ab4c09c21305e
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Myeloid\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	FNIP2 SELL ITGA5 CD53 SIGLEC1 DSE	1.18e-05	199	113	6	d2783e69da653184e38dc6d85b23521790fa24b8
ToppCell	cellseq-Immune-Immune_Myeloid-IM\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	OTOA SH2B3 TMEM176A SIGLEC10 SIGLEC1 DSE	1.18e-05	199	113	6	b3267d5a7ae0461f5e9e6a3ab6783317a8c42506
ToppCell	cellseq-Immune-Immune_Myeloid-IM-IM\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	OTOA SH2B3 TMEM176A SIGLEC10 SIGLEC1 DSE	1.18e-05	199	113	6	01dacee8bb392639d475be3cb27ba3eeff1e57f1
ToppCell	medial-mesenchymal-Alveolar_Fibroblast\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	HGF FRAS1 TMEM176A NCAM2 SVEP1 ITGBL1	1.22e-05	200	113	6	c22cbfecee00183dd4be678f116ab9fd9ad0a4dd
ToppCell	Mild-Myeloid-Macrophages-FCN1-SPP1+\|Mild / Condition, Lineage, Cell class and cell subclass	FNIP2 OTOA TMEM176A SIGLEC1 FUCA2 IL1RN	1.22e-05	200	113	6	e5afd8e2cb2c63899d49fe17011f474d20bb06ea
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Myeloid-Macrophage\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	FNIP2 SELL ITGA5 CD53 SIGLEC1 DSE	1.22e-05	200	113	6	26df6ac63710655604888c3be6509b6c4befc0be
ToppCell	Parenchymal-10x5prime-Stromal-Fibroblastic-Fibro_alveolar\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	HGF FRAS1 TMEM176A NCAM2 SVEP1 ITGBL1	1.22e-05	200	113	6	8c62f05c6042f24287a73fbdf80ff4a56f7ff403
ToppCell	medial-2-mesenchymal-Alveolar_Fibroblast\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	HGF FRAS1 TMEM176A NCAM2 SVEP1 ITGBL1	1.22e-05	200	113	6	cc6062dac07916c29091fc6bee2b864d29e6525b
ToppCell	medial-mesenchymal-Alveolar_Fibroblast-2\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	HGF FRAS1 TMEM176A NCAM2 SVEP1 ITGBL1	1.22e-05	200	113	6	5c0716bf375c8158f7dc2c82bf5eaf37af594dd0
ToppCell	Tracheal-10x3prime_v2-Immune_Myeloid-Macrophage_other-Macrophage_intravascular\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	OTOA SH2B3 TMEM176A SIGLEC10 CD53 SIGLEC1	1.22e-05	200	113	6	c210b98a75ab5d899d7278bc9b577f76a0b3970c
ToppCell	Bronchus_Control_(B.)-Immune-TX-MoAM-1\|Bronchus_Control_(B.) / Sample group, Lineage and Cell type	FNIP2 SH2B3 ITGA5 CD53 IL1RN DSE	1.22e-05	200	113	6	fe7f8b04067b6680b69c8523f0fa514ef97207e2
ToppCell	Parenchymal-NucSeq-Stromal-Fibroblastic-Fibro_alveolar\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	HGF FRAS1 NCAM2 SVEP1 ITGBL1 PKD2	1.22e-05	200	113	6	34f52003988ce6329d8deeee1ab875fa77e01e9d
ToppCell	metastatic_Brain-Myeloid_cells-mo-Mac\|metastatic_Brain / Location, Cell class and cell subclass	OTOA SIGLEC10 CD53 SIGLEC1 IL1RN DSE	1.22e-05	200	113	6	8f702d518f652782b0dd6ca3bdd965a79deb61f3
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Myeloid-Macrophage-macrophage,_alveolar\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	FNIP2 SELL ITGA5 CD53 SIGLEC1 DSE	1.22e-05	200	113	6	07819a90ac347883b78d0bb3cd8c5eb0d66e1e22
ToppCell	343B-Myeloid-Macrophage-SPP1+_Macrophage_4\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	FAM193B RGS11 ODAD2 AGBL5 PKD2	2.44e-05	135	113	5	c4d3c9eba2a85ac40fea5ecfcc2b442a472323d0
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FRAS1 PNLIP GTF2IRD1 SLC12A3 GLDC	3.11e-05	142	113	5	5b6b0c611c83b23ef7289854a515b78f6cf84500
ToppCell	COVID-19-kidney-Mito-rich_(Imm)\|COVID-19 / Disease (COVID-19 only), tissue and cell type	SELL TNFSF9 SLAMF1 CD53 IL1RN	4.59e-05	154	113	5	b437acc11e35fe05389e552d507f6f76e20cc102
ToppCell	TCGA-Thymus-Primary_Tumor-Thymoma-Type_C-8\|TCGA-Thymus / Sample_Type by Project: Shred V9	CARMIL3 NCAM2 KRT80 RELT GNAZ	4.73e-05	155	113	5	00eef9f93a753a1fe1ab5fd8dae026e7be556cde
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell__prolif\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	JCAD VWF OVOL3 KALRN ZBTB46	4.88e-05	156	113	5	f894fac4e44a23718b20ad80c9677bf4f2118002
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Myeloid-Macrophage\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	ODAD2 ITGA5 MCTP1 SIGLEC1 IL1RN	5.18e-05	158	113	5	1635a85fc73c544028418087f36d28957dd4f458
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Myeloid-Macrophage-macrophage,_alveolar\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	ODAD2 ITGA5 MCTP1 SIGLEC1 IL1RN	5.18e-05	158	113	5	80841dadfa53bcde36a3e486408a095f78e772eb
ToppCell	356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_3\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	TNFSF9 EFHB CASKIN2 ZNF839 PLXNA1	5.34e-05	159	113	5	1472536eea61d4f13033efe42f128bae1614fa74
ToppCell	normal_Lung-Myeloid_cells-Undetermined\|Myeloid_cells / Location, Cell class and cell subclass	OTOA ELAPOR2 TMEM176A SLC12A3 CASKIN2	5.67e-05	161	113	5	283012858e575c70d09950de53da041509f59bfa
ToppCell	droplet-Marrow-BM-30m-Myeloid-basophil\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FNIP2 VWF PNLIP ARRDC4 SIGLEC1	5.84e-05	162	113	5	75df7ff779a3b9159ba97d852da1f8df650b9ce5
ToppCell	facs-Pancreas-Exocrine-18m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBXO17 AGBL5 PCDHGB4 FAM53B FBXO27	6.01e-05	163	113	5	953a7db7e90a913e81002d2141fbbd5f1fdf2197
ToppCell	droplet-Lung-30m-Hematologic-myeloid-myeloid_dendritic_cell-myeloid_dendritic_type_1\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TNFSF9 NAGA TMEM176A ZBTB46 FUCA2	6.37e-05	165	113	5	479962ce1c3d6636ae62b6709635299748653801
ToppCell	facs-Kidney-nan-3m-Lymphocytic-B_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SELL DIP2B GMIP CD53 TOP3A	6.55e-05	166	113	5	6a948aefd283a2572da37b59dbc142b6e686b024
ToppCell	facs-Kidney-nan-3m-Lymphocytic-B_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SELL DIP2B GMIP CD53 TOP3A	6.55e-05	166	113	5	8d0c4eb90a2c006f96ae61d3d94c96fb64bc0c4d
ToppCell	droplet-Pancreas-Endocrine-18m-Epithelial-nan\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FNIP2 EPM2A CARMIL3 RGS11 RUNDC3A	6.55e-05	166	113	5	66026988509e39e41274fa0de738383219e8ff30
ToppCell	Adult-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D231\|Adult / Lineage, Cell type, age group and donor	JCAD VWF KALRN ZBTB46 STARD9	6.74e-05	167	113	5	5af9127bae05768a5164d5708a4ad37edca99324
ToppCell	droplet-Pancreas-Endocrine-21m-Epithelial-nan\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAM193B CARMIL3 ANKRD10 F12 RUNDC3A	6.74e-05	167	113	5	b94e8ee8c3fcebedd8fcd719eadddc04c7513c50
ToppCell	droplet-Lung-LUNG-30m-Myeloid-Myeloid_Dendritic_Type_1\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TNFSF9 NAGA ZBTB46 FUCA2 RELT	6.93e-05	168	113	5	2c996d09b6a8ccd3c708146eca310b02eafff425
ToppCell	droplet-Kidney-KIDNEY-30m-Epithelial-brush_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC6A18 UROC1 GPR179 TREH ACKR3	6.93e-05	168	113	5	b14fd50232887b6dca1f39014d43c6f66e5c3b5c
ToppCell	E17.5-Mesenchymal-developing_mesenchymal_cell-mesenchymal_immature_unknown_1\|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	JCAD VWF TMEM176A SVEP1 ACKR3	7.33e-05	170	113	5	7fa022471e14ac8a3bc147c793368a4d56a8e591
ToppCell	3'-Distal_airway-Immune_Myeloid-Dendritic-conventional_dendritic_cell-DC1_(conventional_dendritic_cell)\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SELL ZBTB46 SLC12A3 SIGLEC10 FBXO27	7.54e-05	171	113	5	1018d7bd378ce20bee56a77d5851b3538c55098c
ToppCell	3'-Distal_airway-Immune_Myeloid-Dendritic-conventional_dendritic_cell-DC1_(conventional_dendritic_cell)-DC1_L.1.2.1.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SELL ZBTB46 SLC12A3 SIGLEC10 FBXO27	7.54e-05	171	113	5	6bda333bb751d7835a04f21ac959eea79f2516aa
ToppCell	3'-Distal_airway-Immune_Myeloid-Dendritic-conventional_dendritic_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SELL ZBTB46 SLC12A3 SIGLEC10 FBXO27	7.54e-05	171	113	5	173bb5318fdbaef6e695b6f9e3e0ff4a5432a1a4
ToppCell	3'-Broncho-tracheal-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	OVCH1 SVEP1 TMEFF2 ITGBL1 ACKR3	7.75e-05	172	113	5	e37c0b5b547a7345179ab258dd2141fec7064c17
ToppCell	5'-GW_trimst-2-SmallIntestine-Hematopoietic-Myeloid-pDC\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SELL TNFSF9 SLC12A3 CD53 RELT	7.75e-05	172	113	5	b84610f1e5889a655652800c2b3270d264bfe1a9
ToppCell	BAL-Control-Myeloid-cDC-cDC-cDC_11\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SELL FBXO17 ZBTB46 SLC12A3 FBXO27	8.18e-05	174	113	5	991f7eab69ea3ee1045a4e44ce60a96db13df6d1
ToppCell	E18.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_mature\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	VWF NCAM2 TMEFF2 ACKR3 JAG1	8.40e-05	175	113	5	2e54961846c65b185d9bd6e305dd81205579d890
ToppCell	E18.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	VWF NCAM2 TMEFF2 ACKR3 JAG1	8.40e-05	175	113	5	efa6a05f7417d46141b6e635f258c126b7a03aa1
ToppCell	E16.5-Immune-Immune_Myeloid-Megakaryocyte/Platelet-Megakaryocyte/Platelet\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	VWF KALRN SLAMF1 MCTP1 GNAZ	8.87e-05	177	113	5	84591e28482ab62a5ef41e61043eb64912766356
ToppCell	PBMC-Mild-cDC_11\|Mild / Compartment, Disease Groups and Clusters	RGS11 FBXO17 CASKIN2 SIGLEC10 FBXO27	8.87e-05	177	113	5	974305e4c0eff90134c4e58cf11b955d1eee0501
ToppCell	E16.5-Immune-Immune_Myeloid-Megakaryocyte/Platelet-Megakaryocyte/Platelet-Megakaryocyte/Platelet_mature\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	VWF KALRN SLAMF1 MCTP1 GNAZ	8.87e-05	177	113	5	4bc100062891d07cacd10ffba38966cc6302c92f
ToppCell	E16.5-Immune-Immune_Myeloid-Megakaryocyte/Platelet\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	VWF KALRN SLAMF1 MCTP1 GNAZ	8.87e-05	177	113	5	9f3a2adb9cd4f0a059afc87b6e377a9702154bb1
ToppCell	droplet-Limb_Muscle-nan-24m-Endothelial-unknown\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLAMF1 MCTP1 GNAZ ZNF839 TMEM200C	9.10e-05	178	113	5	f2002a5c4758d0af6c1880ca12f0af0d5e8888e4
Computational	Neighborhood of SELL	SELL GIT2 GMIP CD53	1.40e-04	47	61	4	GNF2_SELL
Computational	Neighborhood of PTPN6	SELL GIT2 GMIP CD53	1.40e-04	47	61	4	GNF2_PTPN6
Computational	Neighborhood of MYD88	SELL SH2B3 GMIP CD53	3.61e-04	60	61	4	GNF2_MYD88
Drug	type-IV	SELL CYB5D2 VWF KRT84 NAGA NCAM2 SIGLEC10 SIGLEC1 FUCA2 VPS13B	1.42e-06	281	113	10	CID000000906
Disease	Vascular Diseases	HGF SLC12A3 PKD2	3.39e-05	17	111	3	C0042373
Disease	sciatic neuropathy (is_implicated_in)	HGF IL1RN	1.39e-04	5	111	2	DOID:11446 (is_implicated_in)
Disease	myositis (is_marker_for)	HGF IL1RN	1.39e-04	5	111	2	DOID:633 (is_marker_for)
Disease	keratoconus (is_implicated_in)	HGF IL1RN	2.08e-04	6	111	2	DOID:10126 (is_implicated_in)
Disease	essential thrombocythemia (is_implicated_in)	VWF SH2B3	2.08e-04	6	111	2	DOID:2224 (is_implicated_in)
Disease	Polyomavirus Infections	HGF GPR179	2.91e-04	7	111	2	C0949804
Disease	alcohol dependence measurement, electroencephalogram measurement	UROC1 DSE	2.91e-04	7	111	2	EFO_0004357, EFO_0007835
Disease	hippocampal CA3 volume	ARRDC4 JAG1 FAM53B	3.38e-04	36	111	3	EFO_0009395
Disease	retinal degeneration (is_implicated_in)	HGF PKD2	4.96e-04	9	111	2	DOID:8466 (is_implicated_in)
Disease	hippocampal CA4 volume	ARRDC4 GMIP FAM53B	4.98e-04	41	111	3	EFO_0009396
Disease	age at onset, alcohol dependence	NCAM2 PMEL ACKR3	5.34e-04	42	111	3	EFO_0004847, MONDO_0007079
Disease	obesity (is_marker_for)	HGF VWF IL1RN SLC27A4	5.85e-04	101	111	4	DOID:9970 (is_marker_for)
Disease	transient cerebral ischemia (is_implicated_in)	F12 IL1RN	7.54e-04	11	111	2	DOID:224 (is_implicated_in)
Disease	middle cerebral artery infarction (is_implicated_in)	F12 IL1RN	9.03e-04	12	111	2	DOID:3525 (is_implicated_in)
Disease	Connective Tissue Diseases	PKD2 FLCN	1.06e-03	13	111	2	C0009782
Disease	neuroticism measurement, cognitive function measurement	SH2B3 KALRN TMEFF2 RUNDC3A AATK MCTP1 NOTO CSMD1	1.37e-03	566	111	8	EFO_0007660, EFO_0008354
Disease	ulcerative colitis (is_implicated_in)	SELL IL1RN	1.84e-03	17	111	2	DOID:8577 (is_implicated_in)
Disease	graft-versus-host disease (is_implicated_in)	HGF IL1RN	1.84e-03	17	111	2	DOID:0081267 (is_implicated_in)
Disease	venous thromboembolism, fibrinogen measurement	DIP2B VWF SH2B3	2.08e-03	67	111	3	EFO_0004286, EFO_0004623
Disease	mitochondrial heteroplasmy measurement	JCAD CIT IL1RN	2.27e-03	69	111	3	EFO_0600008
Disease	carotid artery disease (is_marker_for)	HGF VWF	2.30e-03	19	111	2	DOID:3407 (is_marker_for)
Disease	factor VIII measurement, Ischemic stroke	VWF SH2B3	2.30e-03	19	111	2	EFO_0004630, HP_0002140
Disease	IgA glomerulonephritis (is_marker_for)	SELL IL1RN	2.55e-03	20	111	2	DOID:2986 (is_marker_for)
Disease	temporal horn of lateral ventricle volume measurement	EPM2A CSMD1 IL1RN	2.56e-03	72	111	3	EFO_0010333
Disease	Liver Failure, Acute	HGF IL1RN	3.67e-03	24	111	2	C0162557

Protein segments in the cluster

Peptide	Gene	Start	Entry
SLSDSPSWNCYSRGP	AGBL5	851	Q8NDL9
PPWLGFVSSFSCSNS	EPM2A	306	B3EWF7
SDWTSGPPASCPSDR	CD53	151	P19397
NGSPSSCIASRPSWV	ANKRD10	351	Q9NXR5
NGASWDFPAPFCRAE	CSMD1	191	Q96PZ7
PSSPSAWLNSEANYC	BCAR3	416	O75815
PECFAASWTFDPNPS	LINC01587	66	Q99440
CADCSGPDPSWASVN	GIT2	11	Q14161
WVSSSPCQLSPSGFS	CIT	396	O14578
AWGPSTCPRASASTA	ARRDC4	66	Q8NCT1
ATSCGPASPGRAWQD	RASEF	116	Q8IZ41
SGCLPSNPWISDNDA	RGS11	266	O94810
SSSPASWSCFQPGLC	PCDHGB4	716	Q9UN71
WQDAPASAGPTRTSS	OTOA	1111	Q7RTW8
FRANSVSCWSGPGFR	KRT84	31	Q9NSB2
TFASVWCATRPSDPA	FRAS1	2826	Q86XX4
NSCFDWDSPPRSLAA	MCTP1	796	Q6DN14
PAESSSLSGCGSWQP	FLCN	326	Q8NFG4
SLCPWESTDFRGPSA	GPR179	1426	Q6PRD1
CFSDDSPWSGITERP	PNLIP	26	P16233
PTATVTNEASCWSGP	GMIP	56	Q9P107
ESGAQACWPAPSFQR	ATXN1L	641	P0C7T5
AEASWGSPSACPGAQ	MESP2	216	Q0VG99
SEAGFCNQPPSAWSS	JCAD	91	Q9P266
GPQDQAARSSPCRWT	KCNN1	521	Q92952
WDSCRAPGPGFSSRS	KRT80	31	Q6KB66
GNNSSPCWSPEEESS	CARMIL3	1101	Q8ND23
SAPCGQAGDTWSPDL	FAM53B	201	Q14153
GSQPPFRTFSASDWG	PLXNA1	36	Q9UIW2
SSWCIPLTGAPNSDN	PEX2	221	P28328
RSWCPERNFSGSIPA	FAM218A	91	Q96MZ4
PCKFALWSGRTPSSD	KALRN	1541	O60229
SQPSGSACVHPAFWT	NOTO	66	A8MTQ0
GANPWSVSSCDAFLS	DIP2B	641	Q9P265
IEETTCGPFGNWSSP	SELL	236	P14151
FSPAVSKSCFSPWVG	DSE	486	Q9UL01
NPDGSESPWCFTTDP	HGF	356	P14210
APINNTGFAFPSDWC	FOXJ2	401	Q9P0K8
TGFAFPSDWCSNIDS	FOXJ2	406	Q9P0K8
CPGPGLESSAASRWN	CASKIN2	1066	Q8WXE0
DSRPDGCNNSSWIPR	ELAPOR2	161	A8MWY0
EGGQSAAPSPASWAC	NSUN4	111	Q96CB9
AAPSPASWACSPNLR	NSUN4	116	Q96CB9
SPGGPSASRAAWEAC	HOXB2	231	P14652
WLFSSDCSSLGGPPA	OVOL3	51	O00110
PGAPSQTCFVTSFEW	FBXO17	141	Q96EF6
WGASPTQCTPIEFDS	ITGA5	101	P08648
CPAHSATRFDPTWES	FUCA2	26	Q9BTY2
LWADPGAQACFSRSS	GNAZ	131	P19086
CPGNSGDWDPSSFLS	FAM193B	186	Q96PV7
GRAPKEGPAFSWSCS	FNIP2	26	Q9P278
PGNFSDISWPCNSSD	ACKR3	11	P25106
AVCWSGPASTRATPE	ANGPTL6	41	Q8NI99
SGKFFDRTPCWPSAG	EFHB	251	Q8N7U6
GPTTSFESAACPGWF	IL1RN	131	P18510
PTNGCGPDRWNSAFT	GTF2IRD1	11	Q9UHL9
PGAPSQTCFVTSFSW	FBXO27	146	Q8NI29
DSSRPCAASPQSGSW	FAM53C	201	Q9NYF3
APRPSSWASCSGAAA	SLC22A31	101	A6NKX4
QSFSPSLRSWPGAAC	ITGBL1	26	O95965
DSGSRNPCPSAPTWA	C3orf86	81	P0DN24
QPRSSGWRSPCAAFT	LRRN4	661	Q8WUT4
GWRSPCAAFTTKPSF	LRRN4	666	Q8WUT4
AAAVWPNGTCRVSPS	PCARE	646	A6NGG8
PQLCSSPDSSDVWRG	OTP	291	Q5XKR4
WTGPTCSTNIDDCSP	JAG1	366	P78504
WCSRAEPPDQSFRTG	PLEKHM2	426	Q8IWE5
TTLSGAPCQPWASEA	F12	231	P00748
CAPAGPVSWFSSDGQ	RUNDC3A	76	Q59EK9
TCSVGTWFTPSAPQE	SPAG5	381	Q96R06
NSGSSLPLFDCPTWA	PPP1R8	6	Q12972
CSPPESWGRQSTASS	TMEM200C	356	A6NKL6
CRISSSSDWNTPAPT	TMEM176A	151	Q96HP8
FPTSLSDCQTPTGWN	TMEFF2	41	Q9UIK5
NNSGSRCPESWDPVS	AATK	686	Q6ZMQ8
TSDYEFSNGCRAPPW	ODAD2	226	Q5T2S8
SPDSASWPGCCSEAE	OVCH1	836	Q7RTY7
SNNSQTFSPWPGCRT	SLAMF1	216	Q13291
TFSPWPGCRTDPSET	SLAMF1	221	Q13291
DSWFSCDSKINPSSP	STARD9	1336	Q9P2P6
TFPPCNAEWSSARGS	CYB5D2	171	Q8WUJ1
GPCPSGSWSQKRSFV	PMEL	136	P40967
SNGSWSGSSPSCLPC	SVEP1	2991	Q4LDE5
WSSCPPDLNRTGFVE	SLC6A18	136	Q96N87
TASPDRCFSAWIGAS	ACTRT1	331	Q8TDG2
FSSSPSHRVPWGSCA	LINC00477	106	Q96M19
SPWASSPCRPQDIDF	CNOT2	401	Q9NZN8
DCTGDGPWQSNLAPS	ATP11B	506	Q9Y2G3
RGAEPSCPQGSWAFS	TBC1D17	106	Q9HA65
AWPAAEGSCAAPESS	nan	126	Q6ZSR3
GEQWCERASPPSSSC	VWF	196	P04275
SCRASGSPEPAISWF	NCAM2	231	O15394
PSLSLFCSGSWEPGA	SLC27A4	196	Q6P1M0
FGPFRWVCTSGDPQD	UROC1	446	Q96N76
GDPQPSSFSPSSWCQ	TNKS1BP1	736	Q9C0C2
SNLTPLWAGCFSDPG	TREH	416	O43280
SCFHASITNSPGWRP	SLC12A3	546	P55017
SASPAAAPRGWSEFC	SH2B3	16	Q9UQQ2
QGPTESPTSWGCSDA	SH2D7	306	A6NKC9
CRSGLSPTPDARFSW	SIGLEC1	531	Q9BZZ2
ISRSWFPSAPGSASS	YJU2B	251	P13994
SPPLSSCSRQAWSRD	PKD2	76	Q13563
CPWAVSGARASPGSA	TNFSF9	51	P41273
GSCNFFLWADSPNPG	TOP3A	841	Q13472
TWDSLRSPGFCSPLS	ZNF839	621	A8K0R7
ANRWCAEPSSTVNTP	ZBTB1	156	Q9Y2K1
FSAAWGSSPCQPHAR	RELT	56	Q969Z4
LGFSPAPGADSSQCW	VPS13B	3186	Q7Z7G8
NSSLLCFPRPGSNWD	ZNF648	186	Q5T619
RHPSFSANCGLPSSW	TASOR2	1946	Q5VWN6
SFEVTPSSAGPWANS	SIGLEC10	491	Q96LC7
VSSESGCSTPQGFPW	TRIM66	1166	O15016
SPSCWTKFQRTSPEG	ZMYM3	571	Q14202
ASRAGQPEAGPWSCS	TYSND1	21	Q2T9J0
PTSGWPFSSRDSNAD	ZBTB46	301	Q86UZ6
TLSSCSPWDGRDPQE	ZAR1L	111	A6NP61
SAPQSSPVGRWRFCI	WNK3	861	Q9BYP7
SGPCWAPRSRDSSSG	GLDC	26	P23378
LNATGRPIAFSCSWP	NAGA	176	P17050