Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	NAD-dependent protein lysine deacetylase activity	SIRT5 SIRT1 SIRT2	6.40e-06	7	115	3	GO:0034979
GeneOntologyMolecularFunction	histone H4K16 deacetylase activity, NAD-dependent	SIRT1 SIRT2	3.29e-05	2	115	2	GO:0046970
GeneOntologyMolecularFunction	histone H4K deacetylase activity	SIRT1 SIRT2	1.96e-04	4	115	2	GO:0141051
GeneOntologyMolecularFunction	histone H4K16 deacetylase activity, hydrolytic mechanism	SIRT1 SIRT2	1.96e-04	4	115	2	GO:0034739
GeneOntologyMolecularFunction	NAD+ binding	SIRT5 SIRT1 SIRT2	1.98e-04	20	115	3	GO:0070403
GeneOntologyMolecularFunction	phosphatidylinositol-4,5-bisphosphate binding	CAPG HIP1R AMER3 SNX21 PLA2G4E	2.23e-04	95	115	5	GO:0005546
GeneOntologyMolecularFunction	histone deacetylase activity, NAD-dependent	SIRT1 SIRT2	3.25e-04	5	115	2	GO:0017136
GeneOntologyMolecularFunction	calcium ion binding	CAPN14 EFEMP2 PPEF2 PLA2G4E ZZEF1 RYR3 STAB1 PCDHB18P FBN2 EGFL8 FBN3 NOTCH2 RASGRP2	3.79e-04	749	115	13	GO:0005509
GeneOntologyMolecularFunction	protein lysine deacetylase activity	SIRT5 SIRT1 SIRT2	3.90e-04	25	115	3	GO:0033558
GeneOntologyMolecularFunction	keratin filament binding	EPPK1 SIRT1	4.86e-04	6	115	2	GO:1990254
GeneOntologyMolecularFunction	acyltransferase activity	ATG16L1 NAA15 RMND5A UBR4 CUL9 PLA2G4E ZZEF1 SIRT1 MAP3K1 TRIM7 SIRT2 LNX1 SH3RF3	5.23e-04	775	115	13	GO:0016746
GeneOntologyMolecularFunction	NAD+-protein poly-ADP-ribosyltransferase activity	SIRT5 SIRT1 SIRT2	5.49e-04	28	115	3	GO:0003950
GeneOntologyMolecularFunction	zinc ion binding	CYLD KDM5B MYBBP1A UBR4 CUL9 VAT1L ZZEF1 SIRT5 MAP3K1 TRIM7 ADH4 SIRT2 KDM4A TOP3A	6.05e-04	891	115	14	GO:0008270
GeneOntologyMolecularFunction	NAD+-protein ADP-ribosyltransferase activity	SIRT5 SIRT1 SIRT2	6.75e-04	30	115	3	GO:1990404
GeneOntologyMolecularFunction	phosphatidylinositol bisphosphate binding	CAPG HIP1R AMER3 SNX21 PLA2G4E	6.79e-04	121	115	5	GO:1902936
GeneOntologyMolecularFunction	NAD binding	SIRT5 SIRT1 ADH4 SIRT2	8.37e-04	73	115	4	GO:0051287
GeneOntologyMolecularFunction	phosphatidylinositol phosphate binding	CAPG HIP1R AMER3 SNX21 PLA2G4E ZFYVE26	1.04e-03	199	115	6	GO:1901981
GeneOntologyMolecularFunction	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	SIRT5 SIRT1 FAAH SIRT2	1.23e-03	81	115	4	GO:0016811
GeneOntologyMolecularFunction	transition metal ion binding	CYLD KDM5B MYBBP1A UBR4 CUL9 VAT1L PPEF2 ZZEF1 SIRT5 MAP3K1 TRIM7 ADH4 SIRT2 KDM4A PPM1N TOP3A	1.29e-03	1189	115	16	GO:0046914
GeneOntologyMolecularFunction	deacetylase activity	SIRT5 SIRT1 SIRT2	1.57e-03	40	115	3	GO:0019213
GeneOntologyMolecularFunction	extracellular matrix constituent conferring elasticity	EFEMP2 FBN2	2.09e-03	12	115	2	GO:0030023
GeneOntologyMolecularFunction	histone modifying activity	KDM5B SIRT1 SIRT2 KMT2D BUB1 KDM4A	2.12e-03	229	115	6	GO:0140993
GeneOntologyBiologicalProcess	cholangiocyte proliferation	LIMS2 PKHD1 NOTCH2	1.97e-05	10	115	3	GO:1990705
GeneOntologyBiologicalProcess	morphogenesis of a polarized epithelium	LAMA1 LAMA5 SAPCD2 SPAG6 PKHD1	5.48e-05	73	115	5	GO:0001738
GeneOntologyBiologicalProcess	establishment of mitotic spindle orientation	SAPCD2 PKHD1 GPSM2 GPSM1	6.49e-05	39	115	4	GO:0000132
GeneOntologyBiologicalProcess	process utilizing autophagic mechanism	ATG16L1 ARMC3 UBR4 WDFY4 SIRT1 WDR47 SIRT2 EIF4G1 ZFYVE26 KDM4A EIF4G3 GPSM1 MTMR9	6.87e-05	650	115	13	GO:0061919
GeneOntologyBiologicalProcess	autophagy	ATG16L1 ARMC3 UBR4 WDFY4 SIRT1 WDR47 SIRT2 EIF4G1 ZFYVE26 KDM4A EIF4G3 GPSM1 MTMR9	6.87e-05	650	115	13	GO:0006914
GeneOntologyBiologicalProcess	microtubule-based process	CYLD ATG16L1 ARMC3 CKAP5 CUL9 XRCC3 SAPCD2 SPAG6 SIRT1 WDR47 KIF20A CCNYL1 TTC12 PKHD1 GPSM2 BLOC1S3 GPSM1	7.81e-05	1058	115	17	GO:0007017
GeneOntologyBiologicalProcess	establishment of mitotic spindle localization	SAPCD2 PKHD1 GPSM2 GPSM1	1.05e-04	44	115	4	GO:0040001
GeneOntologyBiologicalProcess	establishment of spindle orientation	SAPCD2 PKHD1 GPSM2 GPSM1	1.25e-04	46	115	4	GO:0051294
GeneOntologyBiologicalProcess	regulation of establishment of planar polarity	SAPCD2 SPAG6 PKHD1	1.53e-04	19	115	3	GO:0090175
GeneOntologyBiologicalProcess	microtubule cytoskeleton organization	CYLD CKAP5 CUL9 XRCC3 SAPCD2 SPAG6 SIRT1 WDR47 KIF20A TTC12 PKHD1 GPSM2 GPSM1	1.90e-04	720	115	13	GO:0000226
GeneOntologyCellularComponent	microfibril	EFEMP2 FBN2 FBN3	4.57e-05	13	116	3	GO:0001527
Domain	ARM-type_fold	MYBBP1A RAP1GDS1 CAND2 ARMC3 UBR4 CKAP5 CUL9 SPAG6 WDFY4 MAP3K1 RYR3 TTC12 EIF4G1 EIF4G3	1.56e-08	339	112	14	IPR016024
Domain	SIR2	SIRT5 SIRT1 SIRT2	7.22e-06	7	112	3	PF02146
Domain	Ssirtuin_cat_dom	SIRT5 SIRT1 SIRT2	7.22e-06	7	112	3	IPR026590
Domain	Sirtuin	SIRT5 SIRT1 SIRT2	7.22e-06	7	112	3	IPR003000
Domain	SIRTUIN	SIRT5 SIRT1 SIRT2	7.22e-06	7	112	3	PS50305
Domain	EGF	EFEMP2 LAMA1 LAMA5 STAB1 FBN2 MALRD1 EGFL8 FBN3 NOTCH2	1.21e-05	235	112	9	SM00181
Domain	EGF-like_dom	EFEMP2 LAMA1 LAMA5 STAB1 FBN2 MALRD1 EGFL8 FBN3 NOTCH2	1.92e-05	249	112	9	IPR000742
Domain	EGF_1	EFEMP2 LAMA1 LAMA5 STAB1 FBN2 MALRD1 EGFL8 FBN3 NOTCH2	2.31e-05	255	112	9	PS00022
Domain	EGF-like_CS	EFEMP2 LAMA1 LAMA5 STAB1 FBN2 MALRD1 EGFL8 FBN3 NOTCH2	2.78e-05	261	112	9	IPR013032
Domain	EGF_2	EFEMP2 LAMA1 LAMA5 STAB1 FBN2 MALRD1 EGFL8 FBN3 NOTCH2	3.13e-05	265	112	9	PS01186
Domain	-	SIRT5 SIRT1 SIRT2	3.34e-05	11	112	3	3.40.50.1220
Domain	Growth_fac_rcpt_	EFEMP2 LAMA1 LAMA5 STAB1 FBN2 FBN3 NOTCH2	4.31e-05	156	112	7	IPR009030
Domain	DHS-like_NAD/FAD-binding_dom	SIRT5 SIRT1 SIRT2	4.44e-05	12	112	3	IPR029035
Domain	-	RAP1GDS1 CAND2 ARMC3 CKAP5 CUL9 SPAG6 WDFY4 TTC12	5.79e-05	222	112	8	1.25.10.10
Domain	-	KDM5B RMND5A BAZ2B PHRF1 MAP3K1 TRIM7 KMT2D ZFYVE26 KDM4A LNX1 SH3RF3	8.13e-05	449	112	11	3.30.40.10
Domain	EGF_CA	EFEMP2 STAB1 FBN2 EGFL8 FBN3 NOTCH2	9.34e-05	122	112	6	SM00179
Domain	Znf_RING/FYVE/PHD	KDM5B RMND5A BAZ2B PHRF1 MAP3K1 TRIM7 KMT2D ZFYVE26 KDM4A LNX1 SH3RF3	9.88e-05	459	112	11	IPR013083
Domain	EGF-like_Ca-bd_dom	EFEMP2 STAB1 FBN2 EGFL8 FBN3 NOTCH2	1.02e-04	124	112	6	IPR001881
Domain	FBN	FBN2 FBN3	1.07e-04	3	112	2	IPR011398
Domain	EGF_CA	EFEMP2 FBN2 EGFL8 FBN3 NOTCH2	1.68e-04	86	112	5	PF07645
Domain	PHD	KDM5B BAZ2B PHRF1 KMT2D KDM4A	1.97e-04	89	112	5	SM00249
Domain	TPR_1	NAA15 SNX21 TTC12 GPSM2 GPSM1	2.08e-04	90	112	5	IPR001440
Domain	TPR_1	NAA15 SNX21 TTC12 GPSM2 GPSM1	2.08e-04	90	112	5	PF00515
Domain	Sirtuin_cat_small_dom	SIRT5 SIRT1	2.12e-04	4	112	2	IPR026591
Domain	-	SIRT5 SIRT1	2.12e-04	4	112	2	3.30.1600.10
Domain	Znf_PHD	KDM5B BAZ2B PHRF1 KMT2D KDM4A	2.19e-04	91	112	5	IPR001965
Domain	ARM-like	RAP1GDS1 CAND2 ARMC3 CKAP5 CUL9 SPAG6 WDFY4 TTC12	2.24e-04	270	112	8	IPR011989
Domain	TPR_2	NAA15 SNX21 TTC12 GPSM1	2.28e-04	50	112	4	PF07719
Domain	TPR_2	NAA15 SNX21 TTC12 GPSM1	2.28e-04	50	112	4	IPR013105
Domain	Znf_FYVE_PHD	KDM5B BAZ2B PHRF1 KMT2D ZFYVE26 KDM4A	2.59e-04	147	112	6	IPR011011
Domain	ZF_PHD_2	KDM5B BAZ2B PHRF1 KMT2D KDM4A	2.67e-04	95	112	5	PS50016
Domain	ZF_PHD_1	KDM5B BAZ2B PHRF1 KMT2D KDM4A	2.81e-04	96	112	5	PS01359
Domain	EGF_Ca-bd_CS	EFEMP2 FBN2 EGFL8 FBN3 NOTCH2	2.95e-04	97	112	5	IPR018097
Domain	EGF_CA	EFEMP2 FBN2 EGFL8 FBN3 NOTCH2	3.24e-04	99	112	5	PS01187
Domain	ASX_HYDROXYL	EFEMP2 FBN2 EGFL8 FBN3 NOTCH2	3.39e-04	100	112	5	PS00010
Domain	Laminin_domII	LAMA1 LAMA5	3.52e-04	5	112	2	IPR010307
Domain	Laminin_aI	LAMA1 LAMA5	3.52e-04	5	112	2	IPR009254
Domain	Laminin_I	LAMA1 LAMA5	3.52e-04	5	112	2	PF06008
Domain	Laminin_II	LAMA1 LAMA5	3.52e-04	5	112	2	PF06009
Domain	HEAT	CAND2 CKAP5 SPAG6 EIF4G3	4.05e-04	58	112	4	IPR000357
Domain	EGF-type_Asp/Asn_hydroxyl_site	EFEMP2 FBN2 EGFL8 FBN3 NOTCH2	4.44e-04	106	112	5	IPR000152
Domain	cEGF	EFEMP2 FBN2 FBN3	4.94e-04	26	112	3	PF12662
Domain	cEGF	EFEMP2 FBN2 FBN3	4.94e-04	26	112	3	IPR026823
Domain	MA3	EIF4G1 EIF4G3	5.26e-04	6	112	2	SM00544
Domain	-	EPPK1 PLEC	5.26e-04	6	112	2	3.90.1290.10
Domain	MA3	EIF4G1 EIF4G3	5.26e-04	6	112	2	PF02847
Domain	Initiation_fac_eIF4g_MI	EIF4G1 EIF4G3	5.26e-04	6	112	2	IPR003891
Domain	MI	EIF4G1 EIF4G3	5.26e-04	6	112	2	PS51366
Domain	EGF_3	EFEMP2 STAB1 FBN2 MALRD1 EGFL8 FBN3 NOTCH2	5.40e-04	235	112	7	PS50026
Domain	hEGF	FBN2 FBN3 NOTCH2	6.17e-04	28	112	3	PF12661
Domain	APC_su10/DOC_dom	CUL9 ZZEF1	7.34e-04	7	112	2	IPR004939
Domain	eIF5C	EIF4G1 EIF4G3	7.34e-04	7	112	2	SM00515
Domain	TB	FBN2 FBN3	7.34e-04	7	112	2	PF00683
Domain	Plectin	EPPK1 PLEC	7.34e-04	7	112	2	PF00681
Domain	DOC	CUL9 ZZEF1	7.34e-04	7	112	2	PS51284
Domain	GoLoco	GPSM2 GPSM1	7.34e-04	7	112	2	SM00390
Domain	GoLoco	GPSM2 GPSM1	7.34e-04	7	112	2	PF02188
Domain	ANAPC10	CUL9 ZZEF1	7.34e-04	7	112	2	PF03256
Domain	Plectin_repeat	EPPK1 PLEC	7.34e-04	7	112	2	IPR001101
Domain	W2	EIF4G1 EIF4G3	7.34e-04	7	112	2	PF02020
Domain	W2	EIF4G1 EIF4G3	7.34e-04	7	112	2	PS51363
Domain	GoLoco_motif	GPSM2 GPSM1	7.34e-04	7	112	2	IPR003109
Domain	APC10	CUL9 ZZEF1	7.34e-04	7	112	2	SM01337
Domain	GOLOCO	GPSM2 GPSM1	7.34e-04	7	112	2	PS50877
Domain	PLEC	EPPK1 PLEC	7.34e-04	7	112	2	SM00250
Domain	W2_domain	EIF4G1 EIF4G3	7.34e-04	7	112	2	IPR003307
Domain	EGF_LAM_2	LAMA1 LAMA5 STAB1	7.57e-04	30	112	3	PS50027
Domain	EGF_LAM_1	LAMA1 LAMA5 STAB1	7.57e-04	30	112	3	PS01248
Domain	Arm	RAP1GDS1 ARMC3 SPAG6	8.35e-04	31	112	3	PF00514
Domain	EGF	STAB1 MALRD1 EGFL8 FBN3 NOTCH2	9.73e-04	126	112	5	PF00008
Domain	-	FBN2 FBN3	9.75e-04	8	112	2	3.90.290.10
Domain	LAMININ_IVA	LAMA1 LAMA5	9.75e-04	8	112	2	PS51115
Domain	Laminin_B	LAMA1 LAMA5	9.75e-04	8	112	2	PF00052
Domain	LamB	LAMA1 LAMA5	9.75e-04	8	112	2	SM00281
Domain	Laminin_IV	LAMA1 LAMA5	9.75e-04	8	112	2	IPR000034
Domain	PHD	KDM5B BAZ2B PHRF1 KMT2D	1.07e-03	75	112	4	PF00628
Domain	EGF_Lam	LAMA1 LAMA5 STAB1	1.19e-03	35	112	3	SM00180
Domain	Laminin_EGF	LAMA1 LAMA5 STAB1	1.19e-03	35	112	3	PF00053
Domain	TB_dom	FBN2 FBN3	1.25e-03	9	112	2	IPR017878
Domain	CTLH	RMND5A WDR47	1.25e-03	9	112	2	SM00668
Domain	TB	FBN2 FBN3	1.25e-03	9	112	2	PS51364
Domain	Znf_PHD-finger	KDM5B BAZ2B PHRF1 KMT2D	1.30e-03	79	112	4	IPR019787
Domain	Laminin_EGF	LAMA1 LAMA5 STAB1	1.52e-03	38	112	3	IPR002049
Domain	MIF4G	EIF4G1 EIF4G3	1.55e-03	10	112	2	SM00543
Domain	JmjN	KDM5B KDM4A	1.55e-03	10	112	2	SM00545
Domain	MIF4G	EIF4G1 EIF4G3	1.55e-03	10	112	2	PF02854
Domain	JmjN	KDM5B KDM4A	1.55e-03	10	112	2	PF02375
Domain	CTLH_C	RMND5A WDR47	1.55e-03	10	112	2	IPR006595
Domain	MIF4G-like_typ-3	EIF4G1 EIF4G3	1.55e-03	10	112	2	IPR003890
Domain	JMJN	KDM5B KDM4A	1.55e-03	10	112	2	PS51183
Domain	CTLH	RMND5A WDR47	1.55e-03	10	112	2	PS50897
Domain	JmjN	KDM5B KDM4A	1.55e-03	10	112	2	IPR003349
Domain	ARM_REPEAT	RAP1GDS1 ARMC3 SPAG6	1.76e-03	40	112	3	PS50176
Domain	ARM	RAP1GDS1 ARMC3 SPAG6	1.76e-03	40	112	3	SM00185
Domain	ZF_RING_1	PHRF1 CUL9 MAP3K1 TRIM7 KMT2D LNX1 SH3RF3	1.87e-03	291	112	7	PS00518
Domain	ZF_RING_2	PHRF1 CUL9 MAP3K1 TRIM7 KMT2D LNX1 SH3RF3	2.13e-03	298	112	7	PS50089
Domain	RING	PHRF1 CUL9 MAP3K1 TRIM7 KMT2D LNX1 SH3RF3	2.43e-03	305	112	7	SM00184
Domain	Galactose-bd-like	LAMA1 LAMA5 CUL9 ZZEF1	2.47e-03	94	112	4	IPR008979
Domain	Armadillo	RAP1GDS1 ARMC3 SPAG6	2.81e-03	47	112	3	IPR000225
Domain	TPR-like_helical_dom	SAMD9 NAA15 SNX21 TTC12 GPSM2 GPSM1	2.82e-03	233	112	6	IPR011990
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	LRRC8E EPPK1 NUP85 MFHAS1 ATP13A1 SPEG UBR4 HIP1R LAMA5 CUL9 FRMD8 ZZEF1 TRIM7 SIRT2 KMT2D EIF4G1 ZFYVE26 PLEC DOCK6 TOP3A NOTCH2 RASAL1	2.09e-11	1105	118	22	35748872
Pubmed	A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.	CYLD TRADD ATG16L1 POLR2B SNX21 XRCC3 SAPCD2 ZBTB1 MAP3K1 KIF20A SPATA2L SIRT2 KCTD3 BLOC1S3 SNAPC3 DOCK6 GPSM1 MTMR9	1.44e-08	1038	118	18	26673895
Pubmed	Altered expression of SIRT gene family in head and neck squamous cell carcinoma.	SIRT5 SIRT1 SIRT2	3.81e-08	3	118	3	23475622
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	CYLD KDM5B RAP1GDS1 ATP13A1 EFEMP2 UBR4 CKAP5 CUL9 MTMR10 RYR3 STAB1 WDR47 GUCY1B1 EIF4G1 GPSM2 KDM4A PLEC EIF4G3 LNX1	6.84e-08	1285	118	19	35914814
Pubmed	Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity.	SIRT5 SIRT1 SIRT2	3.79e-07	5	118	3	10381378
Pubmed	Sirtuin functions in health and disease.	SIRT5 SIRT1 SIRT2	7.56e-07	6	118	3	17456799
Pubmed	Functional proteomics mapping of a human signaling pathway.	RMND5A UBR4 LAMA5 ZZEF1 MTMR10 LIMS2 KMT2D FBN2 MYG1 EIF4G1 PLEC NOTCH2	8.63e-07	591	118	12	15231748
Pubmed	Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins.	SIRT5 SIRT1 SIRT2	1.32e-06	7	118	3	16079181
Pubmed	Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins.	SIRT5 SIRT1 SIRT2	1.32e-06	7	118	3	10873683
Pubmed	Assessing sirtuin expression in endometrial carcinoma and non-neoplastic endometrium.	SIRT5 SIRT1 SIRT2	1.32e-06	7	118	3	26701732
Pubmed	Tagging genes with cassette-exchange sites.	KDM5B NAA15 POLR2B UBR4 PHRF1 SIRT1 DMXL1 EIF4G1 PLEC	2.28e-06	335	118	9	15741177
Pubmed	Sirt3 protects in vitro-fertilized mouse preimplantation embryos against oxidative stress-induced p53-mediated developmental arrest.	SIRT5 SIRT1 SIRT2	3.15e-06	9	118	3	20644252
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	CYLD POLR2B PHRF1 CUL9 ZZEF1 SIRT5 SIRT1 ADH4 KIF20A FBN2 RNH1 TRAF3IP3 MTO1 NOTCH2 ZNF646	5.93e-06	1116	118	15	31753913
Pubmed	GRWD1 regulates ribosomal protein L23 levels via the ubiquitin-proteasome system.	MYBBP1A POLR2B UBR4 CKAP5 UBA1 EIF4G1 EIF4G3	1.10e-05	221	118	7	29991511
Pubmed	The laminin response in inflammatory bowel disease: protection or malignancy?	LAMA1 LAMA5	1.14e-05	2	118	2	25347196
Pubmed	Plakins in development and disease.	EPPK1 PLEC	1.14e-05	2	118	2	17499243
Pubmed	Rs2015 Polymorphism in miRNA Target Site of Sirtuin2 Gene Is Associated with the Risk of Parkinson's Disease in Chinese Han Population.	SIRT1 SIRT2	1.14e-05	2	118	2	31214610
Pubmed	Dynamics and necessity of SIRT1 for maternal-zygotic transition.	SIRT1 SIRT2	1.14e-05	2	118	2	39285243
Pubmed	Reduced gene expression of sirtuins and active AMPK levels in children and adolescents with obesity and insulin resistance.	SIRT1 SIRT2	1.14e-05	2	118	2	29150224
Pubmed	Autism-Misregulated eIF4G Microexons Control Synaptic Translation and Higher Order Cognitive Functions.	EIF4G1 EIF4G3	1.14e-05	2	118	2	31999954
Pubmed	[Correlation between ultrastructural changes of glomerular basement membrane and abnormal distribution of laminins in patients with Alport's syndrome].	LAMA1 LAMA5	1.14e-05	2	118	2	20019771
Pubmed	Expression of sirtuin 1 and 2 is associated with poor prognosis in non-small cell lung cancer patients.	SIRT1 SIRT2	1.14e-05	2	118	2	25915617
Pubmed	Sirtuins 1 and 2 Are Universal Histone Deacetylases.	SIRT1 SIRT2	1.14e-05	2	118	2	26820517
Pubmed	eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation.	EIF4G1 EIF4G3	1.14e-05	2	118	2	10872469
Pubmed	Differential sirtuin expression patterns in amyotrophic lateral sclerosis (ALS) postmortem tissue: neuroprotective or neurotoxic properties of sirtuins in ALS?	SIRT1 SIRT2	1.14e-05	2	118	2	22796962
Pubmed	Resveratrol Induced Premature Senescence Is Associated with DNA Damage Mediated SIRT1 and SIRT2 Down-Regulation.	SIRT1 SIRT2	1.14e-05	2	118	2	25924011
Pubmed	Intracellular nicotinamide adenine dinucleotide promotes TNF-induced necroptosis in a sirtuin-dependent manner.	SIRT5 SIRT2	1.14e-05	2	118	2	26001219
Pubmed	RTN4B-mediated suppression of Sirtuin 2 activity ameliorates β-amyloid pathology and cognitive impairment in Alzheimer's disease mouse model.	SIRT1 SIRT2	1.14e-05	2	118	2	32700357
Pubmed	Presynaptic congenital myasthenic syndrome with a homozygous sequence variant in LAMA5 combines myopia, facial tics, and failure of neuromuscular transmission.	LAMA1 LAMA5	1.14e-05	2	118	2	28544784
Pubmed	Discovery of a potent small molecule SIRT1/2 inhibitor with anticancer effects.	SIRT1 SIRT2	1.14e-05	2	118	2	23900402
Pubmed	Reduced SIRT1 and SIRT2 expression promotes adipogenesis of human visceral adipose stem cells and associates with accumulation of visceral fat in human obesity.	SIRT1 SIRT2	1.14e-05	2	118	2	31462690
Pubmed	Expression analysis and subcellular distribution of the two G-protein regulators AGS3 and LGN indicate distinct functionality. Localization of LGN to the midbody during cytokinesis.	GPSM2 GPSM1	1.14e-05	2	118	2	11832491
Pubmed	SIRT1 and SIRT2 inhibition impairs pediatric soft tissue sarcoma growth.	SIRT1 SIRT2	1.14e-05	2	118	2	25341037
Pubmed	Tissue-specific deregulation of selected HDACs characterizes ALS progression in mouse models: pharmacological characterization of SIRT1 and SIRT2 pathways.	SIRT1 SIRT2	1.14e-05	2	118	2	24946089
Pubmed	SIRT1/2 orchestrate acquisition of DNA methylation and loss of histone H3 activating marks to prevent premature activation of inflammatory genes in macrophages.	SIRT1 SIRT2	1.14e-05	2	118	2	31799621
Pubmed	SIRT1 activation with neuroheal is neuroprotective but SIRT2 inhibition with AK7 is detrimental for disconnected motoneurons.	SIRT1 SIRT2	1.14e-05	2	118	2	29748539
Pubmed	Distinct role of Sirtuin 1 (SIRT1) and Sirtuin 2 (SIRT2) in inhibiting cargo-loading and release of extracellular vesicles.	SIRT1 SIRT2	1.14e-05	2	118	2	31882861
Pubmed	Essential role of SIRT1 signaling in the nucleus accumbens in cocaine and morphine action.	SIRT1 SIRT2	1.14e-05	2	118	2	24107942
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	MYBBP1A EPPK1 NAA15 UBR4 PHRF1 CKAP5 CUL9 RNH1 EIF4G1 PLEC EIF4G3	1.46e-05	653	118	11	22586326
Pubmed	Sirt6 regulates the proliferation of neural precursor cells and cortical neurogenesis in mice.	SIRT5 SIRT1 SIRT2	1.68e-05	15	118	3	38288355
Pubmed	HDAC family: What are the cancer relevant targets?	SIRT5 SIRT1 SIRT2	2.99e-05	18	118	3	18824292
Pubmed	ADAMTS18-fibronectin interaction regulates the morphology of liver sinusoidal endothelial cells.	LAMA1 LAMA5 FBN2	2.99e-05	18	118	3	39040056
Pubmed	Localization and Expression of Sirtuins 1, 2, 6 and Plasticity-Related Proteins in the Recovery Period after a Photothrombotic Stroke in Mice.	SIRT1 SIRT2	3.42e-05	3	118	2	32912518
Pubmed	Regulation of the mitogen-activated protein kinase kinase (MEK)-1 by NAD(+)-dependent deacetylases.	SIRT1 SIRT2	3.42e-05	3	118	2	24681949
Pubmed	Structural characterization of the Z RING-eIF4E complex reveals a distinct mode of control for eIF4E.	EIF4G1 EIF4G3	3.42e-05	3	118	2	20212144
Pubmed	Recurrent mutations in NF-κB pathway components, KMT2D, and NOTCH1/2 in ocular adnexal MALT-type marginal zone lymphomas.	KMT2D NOTCH2	3.42e-05	3	118	2	27566587
Pubmed	Cross-talk between sirtuin and mammalian target of rapamycin complex 1 (mTORC1) signaling in the regulation of S6 kinase 1 (S6K1) phosphorylation.	SIRT1 SIRT2	3.42e-05	3	118	2	24652283
Pubmed	FRMD8 targets both CDK4 activation and RB degradation to suppress colon cancer growth.	FRMD8 FRMD8P1	3.42e-05	3	118	2	37527040
Pubmed	Heterologously overexpressed, affinity-purified human meprin alpha is functionally active and cleaves components of the basement membrane in vitro.	LAMA1 LAMA5	3.42e-05	3	118	2	10620696
Pubmed	Fibulin-2 binds to the short arms of laminin-5 and laminin-1 via conserved amino acid sequences.	LAMA1 LAMA5	3.42e-05	3	118	2	9006922
Pubmed	Inhibition of sirtuins 1 and 2 impairs cell survival and migration and modulates the expression of P-glycoprotein and MRP3 in hepatocellular carcinoma cell lines.	SIRT1 SIRT2	3.42e-05	3	118	2	29545174
Pubmed	Laminin isoform-specific promotion of adhesion and migration of human bone marrow progenitor cells.	LAMA1 LAMA5	3.42e-05	3	118	2	12393739
Pubmed	A newly identified N-terminal amino acid sequence of human eIF4G binds poly(A)-binding protein and functions in poly(A)-dependent translation.	EIF4G1 EIF4G3	3.42e-05	3	118	2	9857202
Pubmed	α1- and α5-containing laminins regulate the development of bile ducts via β1 integrin signals.	LAMA1 LAMA5	3.42e-05	3	118	2	22761447
Pubmed	The G-protein regulator LGN modulates the activity of the NO receptor soluble guanylate cyclase.	GUCY1B1 GPSM2	3.42e-05	3	118	2	22690686
Pubmed	The ADAM17 sheddase complex regulator iTAP/Frmd8 modulates inflammation and tumor growth.	FRMD8 FRMD8P1	3.42e-05	3	118	2	36720499
Pubmed	Sirtuin Inhibition Induces Apoptosis-like Changes in Platelets and Thrombocytopenia.	SIRT1 SIRT2	3.42e-05	3	118	2	25829495
Pubmed	Localization of sirtuins (SIRT1-7) in the aged mouse inner ear.	SIRT5 SIRT1	3.42e-05	3	118	2	26472659
Pubmed	miR‑150 promotes the proliferation and migration of non‑small cell lung cancer cells by regulating the SIRT2/JMJD2A signaling pathway.	SIRT2 KDM4A	3.42e-05	3	118	2	29901178
Pubmed	Plakins: a family of versatile cytolinker proteins.	EPPK1 PLEC	3.42e-05	3	118	2	11854008
Pubmed	Deacetylation of the tumor suppressor protein PML regulates hydrogen peroxide-induced cell death.	SIRT5 SIRT1	3.42e-05	3	118	2	25032863
Pubmed	Altered sirtuin deacetylase gene expression in patients with a mood disorder.	SIRT1 SIRT2	3.42e-05	3	118	2	21349544
Pubmed	Endothelium-derived nitric oxide supports renin cell recruitment through the nitric oxide-sensitive guanylate cyclase pathway.	REN GUCY1B1	3.42e-05	3	118	2	23297374
Pubmed	SIRT2 regulates NF-κB dependent gene expression through deacetylation of p65 Lys310.	SIRT1 SIRT2	3.42e-05	3	118	2	21081649
Pubmed	Identification of 'erasers' for lysine crotonylated histone marks using a chemical proteomics approach.	SIRT1 SIRT2	3.42e-05	3	118	2	25369635
Pubmed	Structural analysis of human KDM5B guides histone demethylase inhibitor development.	KDM5B KDM4A	3.42e-05	3	118	2	27214403
Pubmed	Expression of laminin alpha 1, alpha 5 and beta 2 chains during embryogenesis of the kidney and vasculature.	LAMA1 LAMA5	3.42e-05	3	118	2	9049978
Pubmed	Expression/localization patterns of sirtuins (SIRT1, SIRT2, and SIRT7) during progression of cervical cancer and effects of sirtuin inhibitors on growth of cervical cancer cells.	SIRT1 SIRT2	3.42e-05	3	118	2	25794641
Pubmed	SIRT2 deacetylates FOXO3a in response to oxidative stress and caloric restriction.	SIRT1 SIRT2	3.42e-05	3	118	2	17521387
Pubmed	Distinct patterns of sirtuin expression during progression of Alzheimer's disease.	SIRT5 SIRT1	3.42e-05	3	118	2	24464653
Pubmed	ACAA2 is a ligand-dependent coactivator for thyroid hormone receptor β1.	MFHAS1 KIF20A SPATA2L FBN2 PLEC	4.33e-05	113	118	5	34474245
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	ATG16L1 BAZ2B UBR4 LAMA1 CKAP5 AMER3 ZZEF1 PKHD1 KCNS2 FBN3 MTMR9	4.36e-05	736	118	11	29676528
Pubmed	Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition.	KDM5B KMT2D KDM4A	4.84e-05	21	118	3	27626377
Pubmed	Nutritional stress exacerbates hepatic steatosis induced by deletion of the histidine nucleotide-binding (Hint2) mitochondrial protein.	SIRT5 SIRT1 SIRT2	5.59e-05	22	118	3	26767982
Pubmed	The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.	MYBBP1A NAA15 NUP85 POLR2B UBR4 CKAP5 UBA1 RNH1 EIF4G1 PLEC	6.64e-05	638	118	10	33239621
Pubmed	Expression of laminin chains by central neurons: analysis with gene and protein trapping techniques.	LAMA1 LAMA5	6.82e-05	4	118	2	12820173
Pubmed	Heparin/heparan sulfate controls fibrillin-1, -2 and -3 self-interactions in microfibril assembly.	FBN2 FBN3	6.82e-05	4	118	2	25034023
Pubmed	SIRT1 regulates HIV transcription via Tat deacetylation.	SIRT1 SIRT2	6.82e-05	4	118	2	15719057
Pubmed	Acetylation stabilizes ATP-citrate lyase to promote lipid biosynthesis and tumor growth.	UBR4 SIRT2	6.82e-05	4	118	2	23932781
Pubmed	Spata2L Suppresses TLR4 Signaling by Promoting CYLD-Mediated Deubiquitination of TRAF6 and TAK1.	CYLD SPATA2L	6.82e-05	4	118	2	36180997
Pubmed	Mammalian Pins is a conformational switch that links NuMA to heterotrimeric G proteins.	GPSM2 GPSM1	6.82e-05	4	118	2	15537540
Pubmed	SIRT1 deacetylation and repression of p300 involves lysine residues 1020/1024 within the cell cycle regulatory domain 1.	SIRT1 SIRT2	6.82e-05	4	118	2	15632193
Pubmed	Laminin compensation in collagen alpha3(IV) knockout (Alport) glomeruli contributes to permeability defects.	LAMA1 LAMA5	6.82e-05	4	118	2	17699809
Pubmed	Laminin-1 reexpression in Alport mouse glomerular basement membranes.	LAMA1 LAMA5	6.82e-05	4	118	2	12631063
Pubmed	Reversing chemoresistance by small molecule inhibition of the translation initiation complex eIF4F.	EIF4G1 EIF4G3	6.82e-05	4	118	2	21191102
Pubmed	Altered levels of sirtuin genes (SIRT1, SIRT2, SIRT3 and SIRT6) and their target genes in adipose tissue from individual with obesity.	SIRT1 SIRT2	6.82e-05	4	118	2	30641770
Pubmed	Developmental regulation of the laminin alpha5 chain suggests a role in epithelial and endothelial cell maturation.	LAMA1 LAMA5	6.82e-05	4	118	2	9299121
Pubmed	Subcellular localization of LGN during mitosis: evidence for its cortical localization in mitotic cell culture systems and its requirement for normal cell cycle progression.	GPSM2 GPSM1	6.82e-05	4	118	2	12925752
Pubmed	Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity.	SIRT1 SIRT2	6.82e-05	4	118	2	15220471
Pubmed	Defective Gpsm2/Gαi3 signalling disrupts stereocilia development and growth cone actin dynamics in Chudley-McCullough syndrome.	GPSM2 MYO15A	6.82e-05	4	118	2	28387217
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	MYBBP1A PHRF1 CKAP5 SIRT1 NSUN5 UBA1 KMT2D CCNYL1 EIF4G1 PLEC NOTCH2	6.83e-05	774	118	11	15302935
Pubmed	A protein-protein interaction map of the TNF-induced NF-κB signal transduction pathway.	CYLD TRADD NUP85 SAPCD2 SPATA2L PLEC GPSM1	8.04e-05	302	118	7	30561431
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	CAND2 PHRF1 HIP1R LAMA5 ZZEF1 STAB1 KDM4A DOCK6 ZNF646	8.40e-05	529	118	9	14621295
Pubmed	Adamts18 modulates the development of the aortic arch and common carotid artery.	LAMA1 LAMA5 FBN2	9.35e-05	26	118	3	34189436
Pubmed	Biochemical Reduction of the Topology of the Diverse WDR76 Protein Interactome.	EPPK1 POLR2B LAMA5 SIRT1 FBN2 PLEC	1.07e-04	219	118	6	31353912
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	CYLD MYBBP1A UBR4 CKAP5 ZBTB1 SLC12A5 WDR47 PTPN9 UBA1 EIF4G1 DGKI RASAL1	1.10e-04	963	118	12	28671696
Pubmed	Expression and distribution of laminin alpha1 and alpha2 chains in embryonic and adult mouse tissues: an immunochemical approach.	LAMA1 LAMA5	1.13e-04	5	118	2	11969289
Pubmed	FRMD8 promotes inflammatory and growth factor signalling by stabilising the iRhom/ADAM17 sheddase complex.	FRMD8 FRMD8P1	1.13e-04	5	118	2	29897336
Pubmed	iTAP, a novel iRhom interactor, controls TNF secretion by policing the stability of iRhom/TACE.	FRMD8 FRMD8P1	1.13e-04	5	118	2	29897333
Pubmed	Differential expression of five laminin alpha (1-5) chains in developing and adult mouse kidney.	LAMA1 LAMA5	1.13e-04	5	118	2	9415429
Interaction	APEX2 interactions	MFHAS1 EFEMP2 CUL9 SIRT1 MAP3K1	3.84e-06	41	117	5	int:APEX2
Interaction	TOP3B interactions	LRRC8E EPPK1 NUP85 MFHAS1 ATP13A1 SPEG UBR4 HIP1R LAMA5 CUL9 FRMD8 ZZEF1 TRIM7 SIRT2 KMT2D EIF4G1 ZFYVE26 KDM4A PLEC DOCK6 TOP3A NOTCH2 RASAL1	1.07e-05	1470	117	23	int:TOP3B
Interaction	DYRK1A interactions	CYLD EFEMP2 CKAP5 SIRT1 MAP3K1 STAB1 WDR47 KIF20A KMT2D EIF4G1 EIF4G3 DOCK6 NOTCH2	1.95e-05	552	117	13	int:DYRK1A
GeneFamily	Sirtuins	SIRT5 SIRT1 SIRT2	3.34e-06	7	84	3	938
GeneFamily	EF-hand domain containing\|Plakins	EPPK1 PLEC	5.86e-04	8	84	2	939
GeneFamily	PHD finger proteins	KDM5B BAZ2B PHRF1 KMT2D	8.18e-04	90	84	4	88
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	RAP1GDS1 ARMC3 SPAG6	1.04e-03	43	84	3	409
GeneFamily	Laminin subunits	LAMA1 LAMA5	1.37e-03	12	84	2	626
GeneFamily	Tetratricopeptide repeat domain containing\|Bardet-Biedl syndrome associated\|BBSome	SNX21 TTC12 GPSM2 GPSM1	2.03e-03	115	84	4	769
GeneFamily	Myotubularins\|Phosphoinositide phosphatases	MTMR10 MTMR9	2.15e-03	15	84	2	903
GeneFamily	EF-hand domain containing	CAPN14 PPEF2 ZZEF1 RYR3 RASGRP2	3.54e-03	219	84	5	863
GeneFamily	PHD finger proteins\|Lysine demethylases	KDM5B KDM4A	5.51e-03	24	84	2	485
Coexpression	GSE45739_UNSTIM_VS_ACD3_ACD28_STIM_NRAS_KO_CD4_TCELL_UP	CYLD TRADD NUP85 MFHAS1 UBR4 MAP3K1 LIMS2 TTC12 KCTD3	3.20e-07	200	118	9	M9883
Coexpression	FAN_EMBRYONIC_CTX_EX_4_EXCITATORY_NEURON	CAND2 SPEG LAMA5 RYR3 LIMS2 PLEC FBN3 RASGRP2	8.85e-07	166	118	8	M39026
Coexpression	WHITFIELD_CELL_CYCLE_G2_M	CKAP5 DEPDC1 SAPCD2 ADH4 PTPN9 BUB1 GPSM2	3.28e-05	198	118	7	M2077
Coexpression	GSE33292_WT_VS_TCF1_KO_DN3_THYMOCYTE_UP	CYLD CAND2 BAZ2B LAMA5 KMT2D FBN2 SNAPC3	3.39e-05	199	118	7	M9420
Coexpression	GSE24026_PD1_LIGATION_VS_CTRL_IN_ACT_TCELL_LINE_DN	RAP1GDS1 POLR2B KIF20A RNH1 BUB1 ZFYVE26 MTO1	3.50e-05	200	118	7	M4538
ToppCell	droplet-Heart-HEART-1m-Mesenchymal-nan\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DEPDC1 XRCC3 SAPCD2 KIF20A MSLNL GUCY1B1 KBTBD13 RASGRP2	3.08e-08	182	118	8	c84f44391932080df31c8765e363c3dff64b2bd1
ToppCell	10x5'-bone_marrow-Hematopoietic_progenitors-Cycling_pre-Myeloid-1\|bone_marrow / Manually curated celltypes from each tissue	CAPG DEPDC1 SAPCD2 TRIM7 KIF20A GPSM2 PLEC	5.49e-07	181	118	7	ccd0ed30cea3fb41d34f28b3e8d80a94493bef3c
ToppCell	facs-Marrow-T-cells-3m-Lymphocytic-late_pro-B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CKAP5 DEPDC1 SAPCD2 KIF20A BUB1 GPSM2 KCNS2	6.60e-07	186	118	7	3993f1ef8a33b8a75dfd3db8d4845b5afbb0bb3d
ToppCell	facs-Marrow-T-cells-3m-Lymphocytic-late_pro_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CKAP5 DEPDC1 SAPCD2 KIF20A BUB1 GPSM2 KCNS2	6.60e-07	186	118	7	ec6d0c29e196e374baa96dd3d506f489c959e77e
ToppCell	droplet-Lung-21m-Hematologic-lymphocytic-Proliferating_T_cell-proliferating_T\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DIPK1C DEPDC1 SAPCD2 KIF20A FBN2 BUB1 DGKI	7.88e-07	191	118	7	15dbc5a03bfab8931c0fd385b0f25874736ae874
ToppCell	droplet-Lung-21m-Hematologic-lymphocytic-Proliferating_T_cell\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DIPK1C DEPDC1 SAPCD2 KIF20A FBN2 BUB1 DGKI	7.88e-07	191	118	7	45c15f5ce4a207ac944bed65d45f06c1657d1a6d
ToppCell	PCW_07-8.5-Epithelial-Epithelial_proliferating-epi_proliferating2_(13)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	LAMA1 HIP1R DEPDC1 SAPCD2 KIF20A BUB1 PKHD1	8.17e-07	192	118	7	25378b5e4b0cea8415ff125783511fc25a56fc00
ToppCell	(5)_Dendritic_cell-(52)_cycling_DCs\|(5)_Dendritic_cell / shred on Cell_type and subtype	CAPG CKAP5 DEPDC1 STAB1 KIF20A CD163L1 BUB1	1.04e-06	199	118	7	d0ff446a197062b10f37b585f3f8716d6d89e5b7
ToppCell	10x5'-Lung-Hematopoietic_progenitors-Cycling_pre-Myeloid-2\|Lung / Manually curated celltypes from each tissue	DEPDC1 SAPCD2 STAB1 FBN2 BUB1 GPSM2	5.59e-06	167	118	6	82739226347d74897be000f429b73543a031af96
ToppCell	10x5'-Lung-Hematopoietic_progenitors\|Lung / Manually curated celltypes from each tissue	DEPDC1 SAPCD2 STAB1 FBN2 BUB1 GPSM2	5.59e-06	167	118	6	dec18caf0475002d4ad3c7bc7fc3050cbc8e6bae
ToppCell	E18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_G2M\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CKAP5 SAPCD2 KIF20A PCDHB18P GUCY1B1 RASGRP2	7.30e-06	175	118	6	3e56695a9db97cb1d3503425c48eb79bbf99213e
ToppCell	(01)_Cycling_Basal_(homeostasis)\|World / shred by cell type and Timepoint	CKAP5 DEPDC1 SAPCD2 KIF20A BUB1 GPSM2	7.79e-06	177	118	6	05c57578142a6662f18b294d5cc11e6efd6b0f8e
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_cycling-mes_proliferating1_(15)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	CKAP5 DEPDC1 SAPCD2 KIF20A BUB1 GPSM2	8.58e-06	180	118	6	ed4966765a6b25456f68185cf0648c4a3a21d7fe
ToppCell	droplet-Spleen-SPLEEN-1m-Lymphocytic-immature_NKT_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DEPDC1 SAPCD2 SPAG6 KIF20A BUB1 GPSM2	1.00e-05	185	118	6	736bf89a7a1a840ab6920060f2d98598332065a0
ToppCell	Dividing_Macrophages-Myositis-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	CKAP5 DEPDC1 SAPCD2 KIF20A BUB1 GPSM2	1.03e-05	186	118	6	0067eb78d4c7e32b9563550d9fcaf13445ee6a48
ToppCell	E15.5-Mesenchymal-developing_mesenchymal_cell-mesenchymal_proliferating_cell\|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	CKAP5 DEPDC1 SAPCD2 KIF20A BUB1 GPSM2	1.13e-05	189	118	6	d049f33115610bda4489968759f754730698b9cd
ToppCell	PCW_05-06-Mesenchymal-Mesenchymal_cycling-mes_proliferating2_(11)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	CKAP5 DEPDC1 SAPCD2 KIF20A BUB1 GPSM2	1.20e-05	191	118	6	0ba5b112a82e489f5a21966f78a403a7436ce73b
ToppCell	E17.5-Mesenchymal-developing_mesenchymal_cell-mesenchymal_proliferating_cell\|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	CKAP5 DEPDC1 SAPCD2 KIF20A BUB1 GPSM2	1.20e-05	191	118	6	f764cc21fef87ebad765011098f647ae1bdf6158
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_cycling-mes_proliferating2_(11)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	CKAP5 DEPDC1 SAPCD2 KIF20A BUB1 GPSM2	1.24e-05	192	118	6	27723f4e320e49d4a3daafa2d8d3946ff79fab64
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_cycling-mes_proliferating2_(11)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	CKAP5 DEPDC1 SAPCD2 KIF20A BUB1 GPSM2	1.24e-05	192	118	6	0a54c79dcfdeb99e3b512d42b22359618cfd17e9
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_cycling-mes_proliferating2_(11)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	CKAP5 DEPDC1 SAPCD2 KIF20A BUB1 GPSM2	1.24e-05	192	118	6	026f3e38970bea1e6e8d76a4e2becdfb8484b2ff
ToppCell	PCW_13-14-Epithelial-Epithelial_proliferating-epi_proliferating2_(13)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	HIP1R DEPDC1 SAPCD2 KIF20A BUB1 PKHD1	1.31e-05	194	118	6	c197e4acbff42a9f0410b6801c2bfcf6160aefc1
ToppCell	3'-GW_trimst-1-LargeIntestine-Mesenchymal-immature_mesenchymal_cell-cycling_stromal\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CKAP5 DEPDC1 SAPCD2 KIF20A BUB1 GPSM2	1.35e-05	195	118	6	742c82c86487314cdb3178012004adb1164bcbdb
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-1M-Proliferating-cycling_dorsal_progenitors\|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.	CKAP5 DEPDC1 SAPCD2 KIF20A BUB1 GPSM2	1.47e-05	198	118	6	5f0964c3aa7e1dc52cbb46e754078920b65bcb88
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-1M-Proliferating\|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.	CKAP5 DEPDC1 SAPCD2 KIF20A BUB1 GPSM2	1.47e-05	198	118	6	629d674a9c9108c1acb3f7af57bbdbf34bb0528e
ToppCell	5'-GW_trimst-1-SmallIntestine-Mesenchymal-immature_mesenchymal_cell-cycling_stromal\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CKAP5 DEPDC1 SAPCD2 KIF20A BUB1 GPSM2	1.47e-05	198	118	6	c3dd887c95587f930b7afd32385627a9fa029ca4
ToppCell	Non-neuronal-Dividing-IPC-IPC-div1-28\|World / Primary Cells by Cluster	CKAP5 DEPDC1 SAPCD2 KIF20A BUB1 GPSM2	1.52e-05	199	118	6	787688b68ae5d8768c0a24673ae07ab07616764a
ToppCell	3'-Child04-06-SmallIntestine-Hematopoietic-B_cells-Cycling_plasma_cell\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CKAP5 DEPDC1 SAPCD2 KIF20A BUB1 GPSM2	1.52e-05	199	118	6	c9d15c84b9f8c87b4ea0008be7d5efc5f45efd1a
ToppCell	3'-Adult-LargeIntestine-Epithelial-Tuft-related-BEST4+_epithelial\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SAMD9 REN CCNYL1 CD163L1 PLEC NOTCH2	1.52e-05	199	118	6	01d101b0fd5326947a9e5dddae6c2f93ab6e0a4d
ToppCell	Non-neuronal-Dividing-IPC-IPC-div1\|World / Primary Cells by Cluster	CKAP5 DEPDC1 SAPCD2 KIF20A BUB1 GPSM2	1.52e-05	199	118	6	72823f26ecabcae1b514b7629cfce010c97b929a
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_G2M\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CKAP5 DEPDC1 SAPCD2 KIF20A BUB1 GPSM2	1.52e-05	199	118	6	4af38f5e9d2229d64f7ecdf9c00b4d67e5f86a51
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-2M-Proliferating-cycling_dorsal_progenitors\|Organoid-2M / Sample Type, Dataset, Time_group, and Cell type.	CKAP5 DEPDC1 SAPCD2 KIF20A BUB1 GPSM2	1.52e-05	199	118	6	ca17e8c0f5bc2c41ce28351a7418d934404e563b
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-2M-Proliferating\|Organoid-2M / Sample Type, Dataset, Time_group, and Cell type.	CKAP5 DEPDC1 SAPCD2 KIF20A BUB1 GPSM2	1.52e-05	199	118	6	d8f904f531bfe091b7d8caaa147ea4a03d627995
ToppCell	TCGA-Bladder-Primary_Tumor-Urothelial_Carcinoma\|TCGA-Bladder / Sample_Type by Project: Shred V9	NUP85 ATP13A1 SAPCD2 KIF20A BUB1 BLOC1S3	1.52e-05	199	118	6	8ee3dbc0a92de5f3865e5484970ae2aab7d1a956
ToppCell	TCGA-Bladder-Primary_Tumor\|TCGA-Bladder / Sample_Type by Project: Shred V9	NUP85 ATP13A1 SAPCD2 KIF20A BUB1 BLOC1S3	1.52e-05	199	118	6	c403e28def2e14f5931cd73b4fb9a4078c0439f8
ToppCell	Transverse-Dendritic_cell-cycling_DCs\|Dendritic_cell / Region, Cell class and subclass	CAPG CKAP5 DEPDC1 STAB1 BUB1 GPSM2	1.56e-05	200	118	6	617a6a42f7b31eb3c45bdceaf55a591b6de7f154
ToppCell	Endothelial-H_(cycle)\|World / shred on cell class and cell subclass (v4)	CKAP5 DEPDC1 SAPCD2 KIF20A BUB1	2.80e-05	133	118	5	8e3005114761feee028c496cc739e607b35d7831
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c02-GPR183\|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)	ATG16L1 ATP13A1 SPEG PLA2G4E RYR3	3.23e-05	137	118	5	0c82f815c014d01213d23b466043d6e57186dceb
ToppCell	10x5'-bone_marrow-Myeloid_Monocytic-Cycling_mono\|bone_marrow / Manually curated celltypes from each tissue	CAPG SNX21 STAB1 FBN2 PLEC	4.67e-05	148	118	5	de35eeefad0e27a0d127e2e4bedead2bddb75152
ToppCell	PND07-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_G2M\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SAPCD2 KIF20A CCNYL1 BUB1 LNX1	5.82e-05	155	118	5	8e239470799426ea474a36f57e1b7e0d9365ca5f
ToppCell	10x5'-Lung-Myeloid_Monocytic-Cycling_mono\|Lung / Manually curated celltypes from each tissue	DEPDC1 FAAH STAB1 KIF20A GPSM1	6.00e-05	156	118	5	63b8cf14361b282872bc1c5b65d9fbc83e81a089
ToppCell	Globus_pallidus-Neuronal-Excitatory\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	CYLD RYR3 SPATA2L KCNS2 RASAL1	6.76e-05	160	118	5	f843287ed57d2d5a3b3f6dfb03b6934e330e6645
ToppCell	Globus_pallidus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	CYLD RYR3 SPATA2L KCNS2 RASAL1	6.96e-05	161	118	5	ebcd5066e82b7760b9da6adc02d11258d1309dab
ToppCell	LPS-antiTNF-Epithelial_airway-Mes-Epi-like\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	RYR3 STAB1 KMT2D BUB1 BLOC1S3	7.60e-05	164	118	5	4307b002fb41ddfc7ab8a6bca66a60942c250052
ToppCell	LPS-antiTNF-Epithelial_airway-Mes-Epi-like-Airway\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	RYR3 STAB1 KMT2D BUB1 BLOC1S3	7.60e-05	164	118	5	1d84aa5b925f502ee9c5fa39714490f613a58028
ToppCell	Dividing_Macrophages-Cryobiopsy_01\|World / lung cells shred on cell class, cell subclass, sample id	DEPDC1 SAPCD2 KIF20A BUB1 GPSM2	8.05e-05	166	118	5	c503036f3c19ef186e1e62c9643c49dea3827f51
ToppCell	facs-Heart-LV-24m-Lymphocytic\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARMC3 CAPG WDFY4 TRAF3IP3 RASAL1	8.28e-05	167	118	5	4a669eafde3582a451614ad304769b47aa1d9578
ToppCell	facs-Lung-18m-Hematologic-lymphocytic-regulatory_T_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CAPG VAT1L FAAH DGKI TRAF3IP3	8.51e-05	168	118	5	2d2eab3190374f79f373e31c8b062ff4e1766396
ToppCell	facs-Lung-18m-Hematologic-lymphocytic-regulatory_T_cell-regulatory_T_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CAPG VAT1L FAAH DGKI TRAF3IP3	8.51e-05	168	118	5	df58156721457b34af1e81c0eb8a7243cbbfb303
ToppCell	facs-Heart-LV-24m-Lymphocytic-B_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARMC3 CAPG WDFY4 TRAF3IP3 RASAL1	8.75e-05	169	118	5	ae85cef7ef8f761c19f4af2a23fe333641c38a92
ToppCell	facs-Heart-LV-24m-Lymphocytic-B_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARMC3 CAPG WDFY4 TRAF3IP3 RASAL1	8.75e-05	169	118	5	c01bc3f2f299109086ded83dc11e98559bf1940c
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Immune-Myeloid-Macrophage_Dendritic-Cycling_Mononuclear_Phagocyte\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DEPDC1 WDFY4 KIF20A BUB1 GPSM2	8.75e-05	169	118	5	54b13ab02b4c187f4754045ecfcf409749e7ccc0
ToppCell	5'-GW_trimst-1-SmallIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	DEPDC1 SAPCD2 KIF20A GPSM2 PPM1N	9.25e-05	171	118	5	05014cf6746e6663e376fdd681f1b43a7081c603
ToppCell	5'-GW_trimst-1-SmallIntestine-Mesenchymal-fibroblastic\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	DEPDC1 SAPCD2 KIF20A GPSM2 PPM1N	9.25e-05	171	118	5	d6114db2292fbb27b39d090d51fd305a135b1ccf
ToppCell	PCW_05-06-Mesenchymal-Mesenchymal_cycling-mes_proliferating1_(15)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	CKAP5 DEPDC1 SAPCD2 KIF20A BUB1	9.51e-05	172	118	5	7f3d0ef18f5df1ed80498d435b0378ca398c0b88
ToppCell	390C-Myeloid-Dendritic-cDC_proliferating_1\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	DEPDC1 SAPCD2 FAAH KIF20A BUB1	9.51e-05	172	118	5	6fcc16f1067672967ecbcdfdc727649ae9891dd9
ToppCell	10x5'-lymph-node_spleen-Hematopoietic_progenitors-Cycling_pre-Myeloid-2\|lymph-node_spleen / Manually curated celltypes from each tissue	DEPDC1 SAPCD2 STAB1 KIF20A GPSM2	9.77e-05	173	118	5	783b8fa08b9d8f597f251793eae164151662f1f9
ToppCell	10x5'-lymph-node_spleen-Hematopoietic_progenitors\|lymph-node_spleen / Manually curated celltypes from each tissue	DEPDC1 SAPCD2 STAB1 KIF20A MALRD1	1.00e-04	174	118	5	029394e107bf7ad58056d2216070aa2e964fff12
ToppCell	saliva-Mild-Moderate_progression_d12-25-Myeloid-Macrophage-macrophage,_alveolar-Macro_c1-C1QC\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	CAPG UBR4 DMXL1 ADH4 ANO7	1.00e-04	174	118	5	d77fa525d5c87c190b4a10787b270eabd16c610f
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_G2M\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CKAP5 DEPDC1 KIF20A BUB1 GPSM2	1.00e-04	174	118	5	dbb4e1a6c3319ce40f81bfd2d1745a88a2cc412e
ToppCell	3'-Distal_airway-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.1.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DEPDC1 SAPCD2 KIF20A BUB1 GPSM2	1.00e-04	174	118	5	46cbb462173a684ceb9e680f9259dc3b133763f7
ToppCell	PND03-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_G2M\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CKAP5 DEPDC1 SAPCD2 KIF20A BUB1	1.03e-04	175	118	5	d43ae33a6256606ce848247cad32d74f21b38988
ToppCell	PND10-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_G2M\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DEPDC1 KIF20A GUCY1B1 BUB1 KCTD3	1.03e-04	175	118	5	15c69dd5635c9251c535f1e22467712e9667ae92
ToppCell	367C-Myeloid-Dendritic-cDC_proliferating_1\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	DEPDC1 KIF20A CSRNP3 BUB1 GPSM2	1.03e-04	175	118	5	6b4e841bde6cfa4956e1a0231672cea20f11210c
ToppCell	PND01-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_G2M\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CKAP5 DEPDC1 SAPCD2 KIF20A BUB1	1.06e-04	176	118	5	8385435074cc5235b7af7424974f609388fc2cff
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Cycling_Endothelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	DEPDC1 SAPCD2 TRIM7 KIF20A BUB1	1.09e-04	177	118	5	73ba0f0b4b33f10e9f036d6d9befa48a1258e682
ToppCell	5'-GW_trimst-2-LargeIntestine-Endothelial-blood_vessel_EC-Mature_venous_EC\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	DEPDC1 SAPCD2 KIF20A BUB1 GPSM2	1.12e-04	178	118	5	ea10117026021c959ffc871fc377cdb3e161d264
ToppCell	facs-Marrow-KLS-3m-Myeloid-promonocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SNX21 PPEF2 WDFY4 EGFL8 NOTCH2	1.12e-04	178	118	5	6bad4439a1692332f70135ff446a1048fa4c399d
ToppCell	facs-Marrow-KLS-3m-Myeloid-monocyte_+_promonocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SNX21 PPEF2 WDFY4 EGFL8 NOTCH2	1.12e-04	178	118	5	3f6feb4ed7779cf5684f52939350b41d7718c3c6
ToppCell	facs-Heart-LV-3m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DIPK1C LAMA5 GUCY1B1 KBTBD13 RASGRP2	1.15e-04	179	118	5	8da6863edc756540bb097cc7221c1408640d9bb4
ToppCell	facs-Heart-LV-3m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DIPK1C LAMA5 GUCY1B1 KBTBD13 RASGRP2	1.15e-04	179	118	5	f39c13c99a07d009cc677e363ffe089089c64916
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_cycling-mes_proliferating1_(15)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	CKAP5 DEPDC1 SAPCD2 KIF20A BUB1	1.15e-04	179	118	5	6718cadcc2d3b64717ed84244ef1242d392662dc
ToppCell	droplet-Spleen-nan-21m-Lymphocytic-immature_NKT_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DEPDC1 SAPCD2 SLC12A5 BUB1 GPSM2	1.15e-04	179	118	5	dabecd283c1f0f71a66b804c99be8bd48ea36e35
ToppCell	control-Lymphoid-NKT-proliferating\|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	DEPDC1 SAPCD2 KIF20A BUB1 ANO7	1.18e-04	180	118	5	535535a67b3f3320bad2f98b1bc98a7b0ee77840
ToppCell	10x5'-lymph-node_spleen-Myeloid_Mac-Cycling_Myeloid-Mac\|lymph-node_spleen / Manually curated celltypes from each tissue	DIPK1C DEPDC1 STAB1 KIF20A CD163L1	1.18e-04	180	118	5	4eea8366cdb82c356325ce88f09ad8b302c17a07
ToppCell	PCW_10-12-Immune_Lymphocytic-Immune_Lymphocytic_B-im_B_cell_(15)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	HIP1R WDFY4 TRAF3IP3 RASAL1 RASGRP2	1.21e-04	181	118	5	51e4d6bfdbf414d8e30aee2e6f7492f4f7f54373
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell_cycling-Cycling_Connecting_Tubule_Cell_G2M\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CKAP5 DEPDC1 KIF20A BUB1 GPSM2	1.24e-04	182	118	5	336cd05e46a741185ce3c59ee67a4b07fa6a5101
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial-Oligo-OPC\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HIP1R SAPCD2 MAP3K1 LIMS2 NOTCH2	1.24e-04	182	118	5	3cc61f5f7ad4a81eba3daf65e122880b5af3adc0
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial-Oligo-OPC-OPC_L1-6_MYT1\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HIP1R SAPCD2 MAP3K1 LIMS2 NOTCH2	1.24e-04	182	118	5	5d909e4b5f662905bf1be9c686bbddc3e87d2be9
ToppCell	Adult-Mesenchymal-airway_smooth_muscle_cell-D175\|Adult / Lineage, Cell type, age group and donor	RYR3 MRPS30 DGKI GPSM1 SH3RF3	1.24e-04	182	118	5	ad4d74d8b19976e1ccc3c5ba8013199338cf6fd8
ToppCell	TCGA-Liver-Primary_Tumor-Hepatocellular_Carcinoma-Hepatocellular_Carcinoma-5\|TCGA-Liver / Sample_Type by Project: Shred V9	DEPDC1 SAPCD2 KIF20A BUB1 GPSM2	1.27e-04	183	118	5	f604a8b62c7088fad8365dbf8d910fc980bd3ba8
ToppCell	facs-BAT-Fat-18m-Lymphocytic-B_cell\|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CAPG MAP3K1 TRIM7 TRAF3IP3 NOTCH2	1.30e-04	184	118	5	fd72663bf990266da2fba70d4f2260f8d48067ee
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LAMA1 RYR3 FBN2 PKHD1 MYO15A	1.30e-04	184	118	5	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LAMA1 RYR3 FBN2 PKHD1 MYO15A	1.30e-04	184	118	5	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LAMA1 RYR3 FBN2 PKHD1 MYO15A	1.30e-04	184	118	5	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	PND10-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_B-B-B_G2M\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CAPG CKAP5 DEPDC1 KIF20A BUB1	1.30e-04	184	118	5	8f40093de5bb978f046d66e8f05f333686a009a4
ToppCell	systemic_lupus_erythematosus-treated-Lymphocytic_T-CD4-positive,_alpha-beta_T_cell-female\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	CYLD TRADD SAMD9 TRAF3IP3 MTO1	1.34e-04	185	118	5	406b52516b26e9fe2c9e768950af447ec7ad5f3e
ToppCell	droplet-Lung-1m-Hematologic-lymphocytic-Proliferating_T_cell\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DEPDC1 SAPCD2 FAAH KIF20A BUB1	1.34e-04	185	118	5	0e0f043ad6d2a62cd47ce39911ad81feab4a4d7e
ToppCell	droplet-Lung-1m-Hematologic-lymphocytic-Proliferating_T_cell-proliferating_T\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DEPDC1 SAPCD2 FAAH KIF20A BUB1	1.34e-04	185	118	5	89b85ce8026dc80c1bd9f76dfe16401c173b7946
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_G2M\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CKAP5 DEPDC1 KIF20A BUB1 GPSM2	1.34e-04	185	118	5	30e041d6f6e310d64809e9d6d93cd30052972f3b
ToppCell	systemic_lupus_erythematosus-treated-Lymphocytic_T-CD4-positive,_alpha-beta_T_cell\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	CYLD TRADD SAMD9 TRAF3IP3 MTO1	1.34e-04	185	118	5	f2ebd099c8dfcfaca4298bcdd618c50701a9c2c8
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_cycling-mes_proliferating1_(15)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	CKAP5 DEPDC1 SAPCD2 KIF20A BUB1	1.34e-04	185	118	5	6aeae77a087d695b1e58c5f63265e7113aa2e343
ToppCell	Control-Myeloid-MoAM3,_VCAN\|Myeloid / Condition, Lineage and Cell class	SAPCD2 RYR3 TRIM7 STAB1 FBN2	1.37e-04	186	118	5	0bf16ac48931b62bb3c33d63ff4279654148e293
ToppCell	facs-Liver-Liver_non-hepato/SCs-18m-Lymphocytic-B_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CAPG MAP3K1 TRIM7 NOTCH2 RASGRP2	1.37e-04	186	118	5	a8fcb440d88770f95678c5d28413fc4d847f42a8
ToppCell	facs-Liver-Liver_non-hepato/SCs-18m-Lymphocytic-B_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CAPG MAP3K1 TRIM7 NOTCH2 RASGRP2	1.37e-04	186	118	5	6b2d15e2756d4d4d68ad600e4a6c074edc3488f2
ToppCell	5'-GW_trimst-2-LargeIntestine-Epithelial-epithelial_progenitor_cell-TA\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	DEPDC1 SAPCD2 KIF20A BUB1 GPSM2	1.44e-04	188	118	5	b3cae49f0665ace0016a6441cbf9ae40755b0ea3
ToppCell	droplet-Lung-nan-21m-Lymphocytic-Proliferating_T\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DIPK1C DEPDC1 KIF20A FBN2 DGKI	1.44e-04	188	118	5	61ae7405ab56570409bf35382dc0a038e4137c15
ToppCell	Control-Endothelial-Endothelial-FOXM1\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CKAP5 DEPDC1 KIF20A BUB1 GPSM2	1.48e-04	189	118	5	1e1499b062d9c647c8f38b0c4e0d871d159be5dd
ToppCell	droplet-Spleen-nan-18m-Lymphocytic-immature_NKT_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CKAP5 SAPCD2 KIF20A BUB1 GPSM2	1.52e-04	190	118	5	b99271d139c8d01e20feb95d99f79c9b2756b4cb
ToppCell	(02)_Cycling_Basal_(regeneration)\|World / shred by cell type and Timepoint	DEPDC1 SAPCD2 KIF20A BUB1 GPSM2	1.52e-04	190	118	5	53f017a11ca5ebe9025558e12cedc409cab2e5aa
Drug	Urosiol [128-13-2]; Down 200; 10.2uM; PC3; HT_HG-U133A	CYLD TRADD ATG16L1 CYB5RL SPEG SHB CSRNP3 KDM4A MTMR9	9.37e-07	198	118	9	7243_DN
Disease	connective tissue disease (implicated_via_orthology)	FBN2 FBN3	4.51e-05	3	115	2	DOID:65 (implicated_via_orthology)
Disease	brain cancer (implicated_via_orthology)	GPSM2 GPSM1 NOTCH2	1.40e-04	26	115	3	DOID:1319 (implicated_via_orthology)
Disease	cortical thickness	LAMA1 CUL9 MAP3K1 STAB1 FBN2 MALRD1 KCTD3 PKHD1 DGKI PLEC EIF4G3 LNX1 SH3RF3	4.06e-04	1113	115	13	EFO_0004840
Disease	mean fractional anisotropy measurement	EPPK1 MFHAS1 ZZEF1 PLEC	5.30e-04	95	115	4	EFO_0008399
Disease	cognitive impairment measurement	MFHAS1 SH3RF3 FBN3	6.80e-04	44	115	3	EFO_0007998
Disease	Non-alcoholic Fatty Liver Disease	LAMA1 SIRT1 ADH4	2.61e-03	70	115	3	C0400966
Disease	Nonalcoholic Steatohepatitis	LAMA1 SIRT1 ADH4	2.61e-03	70	115	3	C3241937
Disease	Fetal Growth Retardation	SAMD9 REN	2.73e-03	20	115	2	C0015934
Disease	intellectual disability (implicated_via_orthology)	KDM5B NAA15 UBR4	3.18e-03	75	115	3	DOID:1059 (implicated_via_orthology)
Disease	prostate cancer (is_marker_for)	KDM5B SIRT1 KMT2D KDM4A	3.30e-03	156	115	4	DOID:10283 (is_marker_for)

Protein segments in the cluster

Peptide	Gene	Start	Entry
ELLADASFGLCRALC	AMER3	221	Q8N944
LLEERLGACSCEDNS	EGFL8	271	Q99944
VLTCEAELGVEACRL	BUB1	686	O43683
IDDDANLERVCLLGC	ADH4	166	P08319
LETECLDLRTKLCDL	ATG16L1	141	Q676U5
ICRKGDNEELLLLCD	BAZ2B	1936	Q9UIF8
DNEELLLLCDGCDKG	BAZ2B	1941	Q9UIF8
CDVLLLRGRCIVDEA	ATP13A1	336	Q9HD20
VCAGDELTANELCRL	ARMC3	506	Q5W041
VLCRELNCGDAISLS	CD163L1	831	Q9NR16
SILLACEDVDECGSR	FBN3	1756	Q75N90
LLEEDGRTCKDLDEC	FBN3	2436	Q75N90
NLEAISRLCEDKDLC	CCNYL1	321	Q8N7R7
FLLAGCLRDAIEVCL	DMXL1	1701	Q9Y485
EALLAECLRNGCLFE	CAPN14	31	A8MX76
ALLEELTLGDCRQDL	RASAL1	291	O95294
CSLDICLAQLEELGT	PTPN9	526	P43378
LARAGVSCCELAEED	NSUN5	271	Q96P11
LDREALCDLTEPCIL	PCDHB18P	36	Q96TA0
VRNEECAAGGCLIEL	ANO7	626	Q6IWH7
GTRGLLCEENIDDCA	NOTCH2	1216	Q04721
LDSDGKRLICEVSLC	KIAA0100	166	Q14667
EASCLELALEGERLC	GPSM2	21	P81274
RCELCDVELADLGFV	LIMS2	101	Q7Z4I7
CTVEELLRGCIEAFD	RASGRP2	11	Q7LDG7
LCGERELEEKCLDIH	MFHAS1	541	Q9Y4C4
CLAAQCIDREGASIL	MTMR9	316	Q96QG7
LQEEEGRDLSCCVAS	MTMR10	401	Q9NXD2
SDLDVLCNLLKLCGD	MYO15A	3091	Q9UKN7
ASCLELALEGERLCK	GPSM1	26	Q86YR5
REVDALDGLCSRICD	MTO1	91	Q9Y2Z2
EDCEALGALVCRVQL	FRMD8	166	Q9BZ67
CDEALACALLRLLPE	MYG1	56	Q9HB07
EDCEALGALVCRVQL	FRMD8P1	166	Q9BZ68
ELRAIRLSREDCGCD	CSRNP3	201	Q8WYN3
CERGCFSDLDLIDNL	NUP85	511	Q9BW27
LALDAALGCRIAELC	PPM1N	341	Q8N819
LLLCHSREAILELCD	KCNS2	46	Q9ULS6
KDIARCLLCAGLTED	CYB5RL	296	Q6IPT4
CCAEEVDLDELLAGR	DEPDC1	656	Q5TB30
RSDREDRLLLCDGCD	PHRF1	191	Q9P1Y6
LEEDCCLCSLRGGAL	KDM4A	771	O75164
DDDLICHICLQALLD	LNX1	36	Q8TBB1
ECEDELTGTEISCLR	GUCY1B1	291	Q02153
VCLLCGSGNDEDRLL	KDM5B	311	Q9UGL1
DCVSGDRVRLESELC	KRT82	181	Q9NSB4
TDCRLEILGLEECGL	NLRP4	891	Q96MN2
LAALRELELVACGLE	LRRC8E	581	Q6NSJ5
ELESCLDGCILRTNL	MSLNL	326	Q96KJ4
VCDHCVVLLLDDLER	LAMA5	2166	O15230
GELLLQLCRLEDAAD	NAA15	231	Q9BXJ9
AESCDLLGDIQTCIR	MYBBP1A	611	Q9BQG0
LLIETCLGDERNECK	PLA2G4E	481	Q3MJ16
LRLCDLVDDCGDRTD	MALRD1	841	Q5VYJ5
RAECLEELGCLVESY	CKAP5	1341	Q14008
LIDTCRECGARALEL	HIP1R	721	O75146
LLIDCGDTEACLAAL	SLC2A11	216	Q9BYW1
LFEEDTELCADLCLR	DOCK6	1451	Q96HP0
SSDSEDLLEELLCCL	DYM	141	Q7RTS9
LGILVVRGDCDLETC	DGKI	771	O75912
DSLEGCLDCLLQALA	RAP1GDS1	21	P52306
LLTRDLNCVASGDLC	IFNL3	181	Q8IZI9
RLLAEDDELHLCLAC	HSD17B7	21	P56937
DLCALAERLDIVAGC	BLOC1S3	166	Q6QNY0
NHDEESLECLCRLLT	EIF4G1	926	Q04637
LLDLCLADGIRSAVC	GPR173	61	Q9NS66
LLGCELRDLVTECEK	CUL9	1096	Q8IWT3
LLISDDCFVLDNGLC	CAPG	276	P40121
DVESLALCLRALLCE	FAAH	286	O00519
IDECLVNRLLCDNGL	FBN2	811	P35556
LAGLELEDECAGCTD	CYLD	501	Q9NQC7
LATRLCQDIDECESG	EFEMP2	276	O95967
SLLESCLGQLDICEF	CAND2	1096	O75155
HDEESLECLCRLLTT	EIF4G3	921	O43432
LCEELERSSCGSVLF	KCTD3	111	Q9Y597
AGDLCEDLCVAGELL	DIPK1C	76	Q0P6D2
EDLCVAGELLFQRCL	DIPK1C	81	Q0P6D2
LSLVCLPRSEDDDCD	DRICH1	106	Q6PGQ1
DITDDCICDLARSID	PPEF2	691	O14830
CICEIGILIASLDEV	SLC12A5	566	Q9H2X9
LDEESLTVCEDGCRN	MAP3K1	451	Q13233
ALDLAALRAVACDCL	MRPS30	136	Q9NP92
DICDIFTRDACALLG	RMND5A	261	Q9H871
SRGDAENLLRLCKEC	SHB	416	Q15464
IVDCGALDTLVICLE	SPAG6	121	O75602
VALGCFALRLECEIL	SPATA2L	151	Q8IUW3
DALLADEERCLSCIL	TRADD	126	Q15628
ALEIICENECEGTLL	SAMD9	651	Q5K651
LLCEDGCLALVDTGA	REN	281	P00797
CDDECVGVLLNDLDE	LAMA1	1556	P25391
EAALRCGCLDEDTQR	EPPK1	416	P58107
QLRERCVCDSETGLL	EPPK1	1416	P58107
CLLNGLTDRDLCELN	POLR2B	161	P30876
VELLGDCDVIINELC	SIRT1	476	Q96EB6
LGECDQGCLALAELL	SIRT2	321	Q8IXJ6
LAFLCGLKREEDSCE	PKHD1	1796	P08F94
DCSLEAAAELRAVCG	SNAPC3	91	Q92966
AKIECLQGDRDLCSL	TRAF3IP3	376	Q9Y228
LLCGNGCDDLDLSLL	WDR47	231	O94967
AELQGEATCSICLEL	TRIM7	21	Q9C029
VLIAESCGNRELLCG	SPEG	3036	Q15772
QEVARCLGELLAAAC	SAPCD2	296	Q86UD0
ALFICDGERELAAEL	KBTBD13	126	C9JR72
ISELSLCDLAGSERC	KIF20A	401	O95235
LRSDDVVSCCLDLGV	RYR3	736	Q15413
LLDLLECSVCLERLD	SH3RF3	51	Q8TEJ3
EARACCEKALQLLGD	SNX21	301	Q969T3
LAEDLCLLGCFGALE	WDFY4	711	Q6ZS81
ICSICGLLFEDAESL	ZNF646	576	O15015
LGDEGARLLCETLLE	RNH1	296	P13489
SGDGRVCVAIDECEL	STAB1	896	Q9NY15
RISAEGVDIVLDCLC	VAT1L	241	Q9HCJ6
LDVACARGCLDEETS	PLEC	3291	Q15149
VRALVLELCCNDESG	UBA1	1031	P22314
CIGGCDDTLREILDL	TOP3A	736	Q13472
ASCELCGLTITEEDL	ZBTB1	421	Q9Y2K1
LLNVDISCDGCDEIA	ZZEF1	1776	O43149
DGCLSLLARCEEDVD	TTC12	476	Q9H892
TDQELRDCSSLECLG	nan	161	Q8N1Y9
ILEEVDRELAHCDLC	SIRT5	231	Q9NXA8
CQDCDLVALLEDDSG	UBR4	4391	Q5T4S7
LHLLCEELLEACRTE	ZFYVE26	236	Q68DK2
LLADRLREEEAALGC	XRCC3	296	O43542
ASDPSRLLLCDDCDI	KMT2D	1436	O14686