Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctiontranslation activator activity

DAZ1 DAZ3 DAZ2 DAZ4

2.50e-0815434GO:0008494
GeneOntologyMolecularFunctiontranslation regulator activity, nucleic acid binding

DAZ1 DAZ3 DAZ2 DAZ4

9.78e-05112434GO:0090079
GeneOntologyMolecularFunctioncytoskeletal motor activity

DNAH2 MYO3A KIF5A MYO9B

1.20e-04118434GO:0003774
GeneOntologyMolecularFunctionATP-dependent activity

DNAH2 TMEM30A MYO3A KIF5A MYO9B DICER1 HELB

3.09e-04614437GO:0140657
GeneOntologyMolecularFunctionphosphoprotein phosphatase activity

EYA4 PTPRS LRRD1 PTPRT

7.19e-04189434GO:0004721
GeneOntologyMolecularFunctionprotein tyrosine phosphatase activity

EYA4 PTPRS PTPRT

1.42e-03103433GO:0004725
GeneOntologyMolecularFunctionhydrolase activity, acting on ester bonds

SIAE EYA4 PNLDC1 PTPRS DICER1 LRRD1 PTPRT

1.55e-03807437GO:0016788
GeneOntologyMolecularFunctionheparan sulfate proteoglycan binding

CEACAM21 PTPRS

1.77e-0329432GO:0043395
GeneOntologyMolecularFunctionmRNA 3'-UTR binding

DAZ1 DAZ3 DAZ2 DAZ4

2.89e-03276434GO:0003730
GeneOntologyMolecularFunctionmicrofilament motor activity

MYO3A MYO9B

3.03e-0338432GO:0000146
GeneOntologyMolecularFunctionphosphatase activity

EYA4 PTPRS LRRD1 PTPRT

3.32e-03287434GO:0016791
GeneOntologyMolecularFunctionADP binding

MYO3A MYO9B

4.80e-0348432GO:0043531
GeneOntologyMolecularFunctioncarboxypeptidase activity

PRCP AGBL3

5.00e-0349432GO:0004180
GeneOntologyMolecularFunctionproteoglycan binding

CEACAM21 PTPRS

5.40e-0351432GO:0043394
GeneOntologyBiologicalProcessfemale meiosis II

DAZ1 DAZ3 DAZ2 DAZ4

2.69e-106444GO:0007147
GeneOntologyBiologicalProcessmeiosis II

DAZ1 DAZ3 DAZ2 DAZ4

2.69e-106444GO:0007135
GeneOntologyBiologicalProcessmeiosis II cell cycle process

DAZ1 DAZ3 DAZ2 DAZ4

2.69e-106444GO:0061983
GeneOntologyBiologicalProcesspositive regulation of meiotic nuclear division

DAZ1 DAZ3 DAZ2 DAZ4

2.60e-0726444GO:0045836
GeneOntologyBiologicalProcesspositive regulation of translational initiation

DAZ1 DAZ3 DAZ2 DAZ4

4.11e-0729444GO:0045948
GeneOntologyBiologicalProcess3'-UTR-mediated mRNA stabilization

DAZ1 DAZ3 DAZ2 DAZ4

5.43e-0731444GO:0070935
GeneOntologyBiologicalProcessmRNA stabilization

DAZ1 DAZ3 DAZ2 DICER1 DAZ4

6.16e-0777445GO:0048255
GeneOntologyBiologicalProcessregulation of meiotic cell cycle

ASPM DAZ1 DAZ3 DAZ2 DAZ4

8.44e-0782445GO:0051445
GeneOntologyBiologicalProcesspositive regulation of meiotic cell cycle

DAZ1 DAZ3 DAZ2 DAZ4

1.13e-0637444GO:0051446
GeneOntologyBiologicalProcessnegative regulation of mRNA catabolic process

DAZ1 DAZ3 DAZ2 DICER1 DAZ4

1.13e-0687445GO:1902373
GeneOntologyBiologicalProcessRNA stabilization

DAZ1 DAZ3 DAZ2 DICER1 DAZ4

1.20e-0688445GO:0043489
GeneOntologyBiologicalProcessnegative regulation of RNA catabolic process

DAZ1 DAZ3 DAZ2 DICER1 DAZ4

2.38e-06101445GO:1902369
GeneOntologyBiologicalProcessregulation of meiotic nuclear division

DAZ1 DAZ3 DAZ2 DAZ4

2.52e-0645444GO:0040020
GeneOntologyBiologicalProcessoocyte maturation

DAZ1 DAZ3 DAZ2 DAZ4

3.00e-0647444GO:0001556
GeneOntologyBiologicalProcessnegative regulation of mRNA metabolic process

DAZ1 DAZ3 DAZ2 DICER1 DAZ4

4.51e-06115445GO:1903312
GeneOntologyBiologicalProcessfemale meiotic nuclear division

DAZ1 DAZ3 DAZ2 DAZ4

4.52e-0652444GO:0007143
GeneOntologyBiologicalProcesspositive regulation of translation

DAZ1 PRKDC DAZ3 DAZ2 DAZ4

1.70e-05151445GO:0045727
GeneOntologyBiologicalProcesspositive regulation of nuclear division

DAZ1 DAZ3 DAZ2 DAZ4

1.96e-0575444GO:0051785
GeneOntologyBiologicalProcessoogenesis

ASPM DAZ1 DAZ3 DAZ2 DAZ4

1.99e-05156445GO:0048477
GeneOntologyBiologicalProcessmeiotic cell cycle process

ASPM DAZ1 DAZ3 DAZ2 DICER1 DAZ4

2.12e-05268446GO:1903046
GeneOntologyBiologicalProcessregulation of mRNA stability

DAZ1 PNLDC1 DAZ3 DAZ2 DICER1 DAZ4

3.43e-05292446GO:0043488
GeneOntologyBiologicalProcessregulation of mRNA metabolic process

RBM5 DAZ1 PNLDC1 DAZ3 DAZ2 DICER1 DAZ4

3.88e-05443447GO:1903311
GeneOntologyBiologicalProcessregulation of translational initiation

DAZ1 DAZ3 DAZ2 DAZ4

4.20e-0591444GO:0006446
GeneOntologyBiologicalProcessregulation of RNA stability

DAZ1 PNLDC1 DAZ3 DAZ2 DICER1 DAZ4

4.62e-05308446GO:0043487
GeneOntologyBiologicalProcessregulation of mRNA catabolic process

DAZ1 PNLDC1 DAZ3 DAZ2 DICER1 DAZ4

4.71e-05309446GO:0061013
GeneOntologyBiologicalProcessoocyte development

DAZ1 DAZ3 DAZ2 DAZ4

5.85e-0599444GO:0048599
GeneOntologyBiologicalProcessoocyte differentiation

DAZ1 DAZ3 DAZ2 DAZ4

6.83e-05103444GO:0009994
GeneOntologyBiologicalProcessmeiotic cell cycle

ASPM DAZ1 DAZ3 DAZ2 DICER1 DAZ4

9.37e-05350446GO:0051321
GeneOntologyBiologicalProcessfemale gamete generation

ASPM DAZ1 DAZ3 DAZ2 DAZ4

1.09e-04223445GO:0007292
GeneOntologyBiologicalProcesspositive regulation of reproductive process

DAZ1 DAZ3 DAZ2 DAZ4

1.16e-04118444GO:2000243
GeneOntologyBiologicalProcessmRNA catabolic process

DAZ1 PNLDC1 DAZ3 DAZ2 DICER1 DAZ4

1.33e-04373446GO:0006402
GeneOntologyBiologicalProcessmeiotic nuclear division

ASPM DAZ1 DAZ3 DAZ2 DAZ4

1.53e-04240445GO:0140013
GeneOntologyBiologicalProcessspermatogenesis

ASPM DAZ1 CFAP54 PNLDC1 DAZ3 DAZ2 DICER1 DAZ4

1.55e-04744448GO:0007283
GeneOntologyBiologicalProcesstranslational initiation

DAZ1 DAZ3 DAZ2 DAZ4

1.78e-04132444GO:0006413
GeneOntologyBiologicalProcessmale gamete generation

ASPM DAZ1 CFAP54 PNLDC1 DAZ3 DAZ2 DICER1 DAZ4

1.82e-04762448GO:0048232
GeneOntologyBiologicalProcessregulation of reproductive process

ASPM DAZ1 DAZ3 DAZ2 DAZ4

1.89e-04251445GO:2000241
GeneOntologyBiologicalProcessdevelopmental process involved in reproduction

ASPM DAZ1 CFAP54 PNLDC1 PRKDC DAZ3 DAZ2 DICER1 DAZ4 PTGS2

2.18e-0412354410GO:0003006
GeneOntologyBiologicalProcessRNA catabolic process

DAZ1 PNLDC1 DAZ3 DAZ2 DICER1 DAZ4

2.93e-04432446GO:0006401
GeneOntologyBiologicalProcessnucleic acid catabolic process

DAZ1 PNLDC1 DAZ3 DAZ2 DICER1 DAZ4

4.29e-04464446GO:0141188
GeneOntologyBiologicalProcessregulation of nuclear division

DAZ1 DAZ3 DAZ2 DAZ4

4.89e-04172444GO:0051783
GeneOntologyBiologicalProcessgerm cell development

ASPM DAZ1 CFAP54 DAZ3 DAZ2 DAZ4

5.25e-04482446GO:0007281
GeneOntologyBiologicalProcessmRNA metabolic process

RBM5 DAZ1 PNLDC1 HNRNPUL1 DAZ3 DAZ2 DICER1 DAZ4

6.31e-04917448GO:0016071
GeneOntologyBiologicalProcessnuclear division

ASPM DAZ1 DAZ3 DAZ2 PRICKLE1 DAZ4

7.20e-04512446GO:0000280
GeneOntologyBiologicalProcessmulticellular organismal reproductive process

ASPM DAZ1 CFAP54 PNLDC1 DAZ3 DAZ2 DICER1 DAZ4 PTGS2

7.98e-041194449GO:0048609
GeneOntologyBiologicalProcesscellular process involved in reproduction in multicellular organism

ASPM DAZ1 CFAP54 DAZ3 DAZ2 DAZ4

8.37e-04527446GO:0022412
GeneOntologyBiologicalProcessanatomical structure maturation

DAZ1 DAZ3 DAZ2 DAZ4 PTGS2

9.07e-04354445GO:0071695
GeneOntologyBiologicalProcessregulation of postsynaptic density assembly

PRICKLE1 PTPRS

9.10e-0421442GO:0099151
GeneOntologyBiologicalProcessgamete generation

ASPM DAZ1 CFAP54 PNLDC1 DAZ3 DAZ2 DICER1 DAZ4

9.87e-04982448GO:0007276
GeneOntologyBiologicalProcessregulation of stem cell differentiation

PRKDC PRICKLE1 DICER1

1.23e-0399443GO:2000736
GeneOntologyBiologicalProcessorganelle fission

ASPM DAZ1 DAZ3 DAZ2 PRICKLE1 DAZ4

1.27e-03571446GO:0048285
GeneOntologyBiologicalProcessregulation of postsynaptic specialization assembly

PRICKLE1 PTPRS

1.40e-0326442GO:0099150
GeneOntologyBiologicalProcessregulation of excitatory synapse assembly

PRICKLE1 PTPRS

1.40e-0326442GO:1904889
GeneOntologyBiologicalProcessvesicle targeting, rough ER to cis-Golgi

TRAPPC11 TFG

1.51e-0327442GO:0048207
GeneOntologyBiologicalProcessCOPII vesicle coating

TRAPPC11 TFG

1.51e-0327442GO:0048208
GeneOntologyBiologicalProcessregulation of postsynaptic density organization

PRICKLE1 PTPRS

1.51e-0327442GO:1905874
GeneOntologyBiologicalProcesscartilage development

HOXA3 CARM1 FGF6 DICER1

1.76e-03243444GO:0051216
GeneOntologyBiologicalProcessnegative regulation of catabolic process

DAZ1 DAZ3 DAZ2 DICER1 DAZ4

1.89e-03418445GO:0009895
HumanPhenoY-linked inheritance

DAZ1 DAZ3 DAZ2

2.02e-0518163HP:0001450
HumanPhenoMale infertility

DNAH2 DAZ1 PNLDC1 DAZ3 DAZ2 DAZ4

2.52e-05209166HP:0003251
HumanPhenoOligozoospermia

DAZ1 DAZ3 DAZ2 DAZ4

2.66e-0559164HP:0000798
HumanPhenoDecreased fertility in males

DNAH2 DAZ1 PNLDC1 DAZ3 DAZ2 DAZ4

5.02e-05236166HP:0012041
HumanPhenoInfertility

DNAH2 DAZ1 PNLDC1 DAZ3 DAZ2 DAZ4

2.47e-04314166HP:0000789
HumanPhenoDecreased testicular size

DAZ1 PNLDC1 DAZ3 DAZ2 DAZ4

2.72e-04200165HP:0008734
MousePhenosmall ovary

ASPM DAZ1 DAZ3 DAZ2 DAZ4 PTGS2

5.56e-06178366MP:0001127
MousePhenoabsent ovarian follicles

DAZ1 DAZ3 DAZ2 DAZ4

8.49e-0651364MP:0002777
MousePhenoabnormal ovary size

ASPM DAZ1 DAZ3 DAZ2 DAZ4 PTGS2

2.28e-05228366MP:0004853
MousePhenoarrest of spermatogenesis

RBM5 DAZ1 PNLDC1 DAZ3 DAZ2 DAZ4

2.97e-05239366MP:0001155
MousePhenooligozoospermia

DNAH2 ASPM DAZ1 CFAP54 DAZ3 DAZ2 DAZ4

4.69e-05384367MP:0002687
MousePhenoabnormal gametogenesis

DNAH2 ASPM RBM5 DAZ1 CFAP54 PNLDC1 DAZ3 DAZ2 DICER1 DAZ4 PTGS2

5.06e-0510703611MP:0001929
MousePhenoinfertility

DNAH2 RBM5 DAZ1 CFAP54 EYA4 PNLDC1 DAZ3 DAZ2 DICER1 DAZ4 PTGS2

1.31e-0411883611MP:0001924
MousePhenoabnormal sperm number

DNAH2 ASPM RBM5 DAZ1 CFAP54 DAZ3 DAZ2 DAZ4

1.50e-04624368MP:0002673
MousePhenodecreased male germ cell number

DNAH2 ASPM RBM5 DAZ1 CFAP54 DAZ3 DAZ2 DAZ4

1.79e-04640368MP:0004901
MousePhenoincreased heart right atrium size

CARM1 PRICKLE1

2.86e-0410362MP:0008727
MousePhenoabnormal female reproductive system physiology

ASPM DAZ1 GREB1 DAZ3 DAZ2 PTPRS DICER1 DAZ4 PTGS2

2.89e-04876369MP:0003699
MousePhenodecreased germ cell number

DNAH2 ASPM RBM5 DAZ1 CFAP54 DAZ3 DAZ2 DAZ4

2.90e-04687368MP:0002209
MousePhenoabnormal ovarian follicle morphology

DAZ1 DAZ3 DAZ2 DAZ4 PTGS2

3.84e-04245365MP:0001131
MousePhenoabnormal spermatogenesis

DNAH2 ASPM RBM5 DAZ1 CFAP54 PNLDC1 DAZ3 DAZ2 DAZ4

3.84e-04910369MP:0001156
MousePhenoperitoneal inflammation

ST6GAL1 PTGS2

4.19e-0412362MP:0003303
MousePhenomale infertility

DNAH2 RBM5 DAZ1 CFAP54 EYA4 PNLDC1 DAZ3 DAZ2 DAZ4

5.03e-04944369MP:0001925
MousePhenoabnormal germ cell morphology

DNAH2 ASPM RBM5 DAZ1 CFAP54 DAZ3 DAZ2 DAZ4 PTGS2

5.11e-04946369MP:0002208
MousePhenoabnormal foam cell morphology

DNAH2 ASPM RBM5 DAZ1 CFAP54 DAZ3 DAZ2 DAZ4 PTGS2

5.43e-04954369MP:0009840
MousePhenofemale infertility

DAZ1 DAZ3 DAZ2 DICER1 DAZ4 PTGS2

5.67e-04410366MP:0001926
DomainRRM_1

RBM5 DAZ1 DAZ3 DAZ2 DAZ4

1.25e-04208445PF00076
DomainP-loop_NTPase

DNAH2 ASPM MYO3A KIF5A HNRNPUL1 MYO9B DICER1 GIMAP6 HELB

1.33e-04848449IPR027417
DomainRRM

RBM5 DAZ1 DAZ3 DAZ2 DAZ4

1.52e-04217445SM00360
DomainRRM_dom

RBM5 DAZ1 DAZ3 DAZ2 DAZ4

1.87e-04227445IPR000504
DomainRRM

RBM5 DAZ1 DAZ3 DAZ2 DAZ4

1.99e-04230445PS50102
Domain-

RBM5 DAZ1 DAZ3 DAZ2 DAZ4

2.62e-042444453.30.70.330
DomainNucleotide-bd_a/b_plait

RBM5 DAZ1 DAZ3 DAZ2 DAZ4

3.38e-04258445IPR012677
DomainOlfac-like_dom

OLFML2A OLFM3

4.16e-0413442IPR003112
DomainOLF

OLFML2A OLFM3

4.16e-0413442SM00284
DomainOLF

OLFML2A OLFM3

4.16e-0413442PF02191
DomainOLF

OLFML2A OLFM3

4.16e-0413442PS51132
DomainIQ

ASPM MYO3A MYO9B

6.23e-0471443PF00612
DomainIQ

ASPM MYO3A MYO9B

9.16e-0481443SM00015
DomainIQ_motif_EF-hand-BS

ASPM MYO3A MYO9B

1.24e-0390443IPR000048
DomainIQ

ASPM MYO3A MYO9B

1.37e-0393443PS50096
DomainPTPc

PTPRS PTPRT

3.25e-0336442SM00194
DomainMYOSIN_MOTOR

MYO3A MYO9B

3.61e-0338442PS51456
DomainMyosin_head

MYO3A MYO9B

3.61e-0338442PF00063
DomainMyosin_head_motor_dom

MYO3A MYO9B

3.61e-0338442IPR001609
DomainMYSc

MYO3A MYO9B

3.61e-0338442SM00242
DomainTYR_PHOSPHATASE_PTP

PTPRS PTPRT

3.80e-0339442PS50055
DomainPTPase_domain

PTPRS PTPRT

4.20e-0341442IPR000242
DomainY_phosphatase

PTPRS PTPRT

4.20e-0341442PF00102
DomainTPR

DNAH2 PRKDC P3H1

6.88e-03165443PS50005
DomainTPR_REGION

DNAH2 PRKDC P3H1

6.88e-03165443PS50293
DomainPTPc_motif

PTPRS PTPRT

8.52e-0359442SM00404
DomainTyr_Pase_cat

PTPRS PTPRT

8.52e-0359442IPR003595
DomainTyr_Pase_AS

PTPRS PTPRT

1.28e-0273442IPR016130
PathwayWP_OVARIAN_INFERTILITY

DAZ1 DAZ3 DAZ2 DAZ4

9.55e-0735314MM15948
Pubmed

Analysis of the DAZ gene family in cryptorchidism and idiopathic male infertility.

DAZ1 DAZ3 DAZ2 DAZ4

2.23e-12444415066457
Pubmed

Diverse spermatogenic defects in humans caused by Y chromosome deletions encompassing a novel RNA-binding protein gene.

DAZ1 DAZ3 DAZ2 DAZ4

2.23e-1244447670487
Pubmed

Male infertility, genetic analysis of the DAZ genes on the human Y chromosome and genetic analysis of DNA repair.

DAZ1 DAZ3 DAZ2 DAZ4

2.23e-12444411694340
Pubmed

The human DAZ genes, a putative male infertility factor on the Y chromosome, are highly polymorphic in the DAZ repeat regions.

DAZ1 DAZ3 DAZ2 DAZ4

2.23e-1244449321470
Pubmed

Polymorphic expression of DAZ proteins in the human testis.

DAZ1 DAZ3 DAZ2 DAZ4

2.23e-12444419223287
Pubmed

Male infertility caused by a de novo partial deletion of the DAZ cluster on the Y chromosome.

DAZ1 DAZ3 DAZ2 DAZ4

2.23e-12444411095434
Pubmed

Impact of partial DAZ1/2 deletion and partial DAZ3/4 deletion on male infertility.

DAZ1 DAZ3 DAZ2 DAZ4

2.23e-12444426232607
Pubmed

[Microdeletion of chromosome Y in male infertility: role of the DAZ gene].

DAZ1 DAZ3 DAZ2 DAZ4

2.23e-12444411688365
Pubmed

Polymorphic DAZ gene family in polymorphic structure of AZFc locus: Artwork or functional for human spermatogenesis?

DAZ1 DAZ3 DAZ2 DAZ4

2.23e-12444412752250
Pubmed

A novel approach for the analysis of DAZ gene copy number in severely idiopathic infertile men.

DAZ1 DAZ3 DAZ2 DAZ4

2.23e-12444411883873
Pubmed

Four DAZ genes in two clusters found in the AZFc region of the human Y chromosome.

DAZ1 DAZ3 DAZ2 DAZ4

2.23e-12444410936047
Pubmed

[Study on DAZ gene copy deletion in severe oligozoospermia sperm donor for ICSI].

DAZ1 DAZ3 DAZ2 DAZ4

2.23e-12444416963411
Pubmed

Partial DAZ deletions in a family with five infertile brothers.

DAZ1 DAZ3 DAZ2 DAZ4

2.23e-12444412801575
Pubmed

Connecting cis-elements and trans-factors with mechanisms of developmental regulation of mRNA translation in meiotic and haploid mammalian spermatogenic cells.

DAZ1 DAZ3 DAZ2 DAZ4

1.11e-11544423579190
Pubmed

Kinked β-strands mediate high-affinity recognition of mRNA targets by the germ-cell regulator DAZL.

DAZ1 DAZ3 DAZ2 DAZ4

1.11e-11544422021443
Pubmed

The mouse Dazla gene encodes a cytoplasmic protein essential for gametogenesis.

DAZ1 DAZ3 DAZ2 DAZ4

1.11e-1154449288969
Pubmed

The dazzle in germ cell differentiation.

DAZ1 DAZ3 DAZ2 DAZ4

1.11e-11544420008336
Pubmed

Co-culture of spermatogonial stem cells with sertoli cells in the presence of testosterone and FSH improved differentiation via up-regulation of post meiotic genes.

DAZ1 DAZ3 DAZ2 DAZ4

1.11e-11544423456578
Pubmed

Isolation of a mouse homolog of the human DAZ (Deleted in Azoospermia) gene.

DAZ1 DAZ3 DAZ2 DAZ4

1.11e-1154448679003
Pubmed

In vivo and in vitro analysis of homodimerisation activity of the mouse Dazl1 protein.

DAZ1 DAZ3 DAZ2 DAZ4

1.11e-11544410903443
Pubmed

Gene sequence, localization, and evolutionary conservation of DAZLA, a candidate male sterility gene.

DAZ1 DAZ3 DAZ2 DAZ4

1.11e-1154449143498
Pubmed

Bisphenol A exposure modifies DNA methylation of imprint genes in mouse fetal germ cells.

DAZ1 DAZ3 DAZ2 DAZ4

1.11e-11544422699882
Pubmed

A murine homologue of the human DAZ gene is autosomal and expressed only in male and female gonads.

DAZ1 DAZ3 DAZ2 DAZ4

1.11e-1154448845845
Pubmed

DAZ family proteins exist throughout male germ cell development and transit from nucleus to cytoplasm at meiosis in humans and mice.

DAZ1 DAZ3 DAZ2 DAZ4

1.11e-11544411058556
Pubmed

AZFc partial deletions in Chilean men with severe spermatogenic failure.

DAZ1 DAZ3 DAZ2 DAZ4

1.11e-11544417416365
Pubmed

Dazl promotes germ cell differentiation from embryonic stem cells.

DAZ1 DAZ3 DAZ2 DAZ4

1.11e-11544419783541
Pubmed

Retinoic acid regulates germ cell differentiation in mouse embryonic stem cells through a Smad-dependent pathway.

DAZ1 DAZ3 DAZ2 DAZ4

1.11e-11544422293198
Pubmed

DAZL protein expression in mouse preimplantation embryo.

DAZ1 DAZ3 DAZ2 DAZ4

1.11e-11544417761180
Pubmed

Dazl functions in maintenance of pluripotency and genetic and epigenetic programs of differentiation in mouse primordial germ cells in vivo and in vitro.

DAZ1 DAZ3 DAZ2 DAZ4

1.11e-11544419468308
Pubmed

Partial rescue of the Dazl knockout mouse by the human DAZL gene.

DAZ1 DAZ3 DAZ2 DAZ4

1.11e-11544412200456
Pubmed

Nature of the spermatogenic arrest in Dazl -/- mice.

DAZ1 DAZ3 DAZ2 DAZ4

1.11e-11544411514340
Pubmed

Loss of oocytes in Dazl knockout mice results in maintained ovarian steroidogenic function but altered gonadotropin secretion in adult animals.

DAZ1 DAZ3 DAZ2 DAZ4

1.11e-11544411089564
Pubmed

Mouse Dazl and its novel splice variant functions in translational repression of target mRNAs in embryonic stem cells.

DAZ1 DAZ3 DAZ2 DAZ4

1.11e-11544423298641
Pubmed

DAZL is essential for stress granule formation implicated in germ cell survival upon heat stress.

DAZ1 DAZ3 DAZ2 DAZ4

1.11e-11544422223682
Pubmed

A human DAZ transgene confers partial rescue of the mouse Dazl null phenotype.

DAZ1 DAZ3 DAZ2 DAZ4

1.11e-11544410393944
Pubmed

The human autosomal gene DAZLA: testis specificity and a candidate for male infertility.

DAZ1 DAZ3 DAZ2 DAZ4

1.11e-1154448968756
Pubmed

A SPGY copy homologous to the mouse gene Dazla and the Drosophila gene boule is autosomal and expressed only in the human male gonad.

DAZ1 DAZ3 DAZ2 DAZ4

1.11e-1154448968755
Pubmed

DAZL Regulates Germ Cell Survival through a Network of PolyA-Proximal mRNA Interactions.

DAZ1 DAZ3 DAZ2 DAZ4

1.11e-11544430380414
Pubmed

Regulated Formation of an Amyloid-like Translational Repressor Governs Gametogenesis.

DAZ1 DAZ3 DAZ2 DAZ4

1.11e-11544426411291
Pubmed

Germline DNA demethylation dynamics and imprint erasure through 5-hydroxymethylcytosine.

DAZ1 DAZ3 DAZ2 DAZ4

1.11e-11544423223451
Pubmed

Somatic cell-derived BMPs induce premature meiosis in male germ cells during the embryonic stage by upregulating Dazl expression.

DAZ1 DAZ3 DAZ2 DAZ4

1.11e-11544434985827
Pubmed

Identification of target messenger RNA substrates for the murine deleted in azoospermia-like RNA-binding protein.

DAZ1 DAZ3 DAZ2 DAZ4

1.11e-11544411804965
Pubmed

Expression profiling of the developing testis in wild-type and Dazl knockout mice.

DAZ1 DAZ3 DAZ2 DAZ4

1.11e-11544414648873
Pubmed

The DAZ gene cluster on the human Y chromosome arose from an autosomal gene that was transposed, repeatedly amplified and pruned.

DAZ1 DAZ3 DAZ2 DAZ4

1.11e-1154448896558
Pubmed

Evolution of the DAZ gene family suggests that Y-linked DAZ plays little, or a limited, role in spermatogenesis but underlines a recent African origin for human populations.

DAZ1 DAZ3 DAZ2 DAZ4

1.11e-1154449700189
Pubmed

Decreased oocyte DAZL expression in mice results in increased litter size by modulating follicle-stimulating hormone-induced follicular growth.

DAZ1 DAZ3 DAZ2 DAZ4

1.11e-11544421270429
Pubmed

Mouse autosomal homolog of DAZ, a candidate male sterility gene in humans, is expressed in male germ cells before and after puberty.

DAZ1 DAZ3 DAZ2 DAZ4

1.11e-1154448661148
Pubmed

Expression profiles of the DAZ gene family in human testis with and without spermatogenic failure.

DAZ1 DAZ3 DAZ2 DAZ4

3.33e-11644415066460
Pubmed

DAZL binds to the transcripts of several Tssk genes in germ cells.

DAZ1 DAZ3 DAZ2 DAZ4

3.33e-11644418452650
Pubmed

A developmental stage-specific switch from DAZL to BOLL occurs during fetal oogenesis in humans, but not mice.

DAZ1 DAZ3 DAZ2 DAZ4

3.33e-11644424086306
Pubmed

DAZL binds to 3'UTR of Tex19.1 mRNAs and regulates Tex19.1 expression.

DAZ1 DAZ3 DAZ2 DAZ4

3.33e-11644419247806
Pubmed

DAZL is a master translational regulator of murine spermatogenesis.

DAZ1 DAZ3 DAZ2 DAZ4

3.33e-11644431355046
Pubmed

The fate of granulosa cells following premature oocyte loss and the development of ovarian cancers.

DAZ1 DAZ3 DAZ2 DAZ4

3.33e-11644423417416
Pubmed

The RNA-binding protein DAZL functions as repressor and activator of mRNA translation during oocyte maturation.

DAZ1 DAZ3 DAZ2 DAZ4

3.33e-11644432170089
Pubmed

Dazl binds in vivo to specific transcripts and can regulate the pre-meiotic translation of Mvh in germ cells.

DAZ1 DAZ3 DAZ2 DAZ4

3.33e-11644416278232
Pubmed

Aged mouse ovaries possess rare premeiotic germ cells that can generate oocytes following transplantation into a young host environment.

DAZ1 DAZ3 DAZ2 DAZ4

3.33e-11644420157580
Pubmed

A gene trap mutation of a murine homolog of the Drosophila stem cell factor Pumilio results in smaller testes but does not affect litter size or fertility.

DAZ1 DAZ3 DAZ2 DAZ4

3.33e-11644417219433
Pubmed

Mono-butyl phthalate-induced mouse testis injury is associated with oxidative stress and down-regulated expression of Sox9 and Dazl.

DAZ1 DAZ3 DAZ2 DAZ4

3.33e-11644428496037
Pubmed

DAZL regulates Tet1 translation in murine embryonic stem cells.

DAZ1 DAZ3 DAZ2 DAZ4

3.33e-11644426077710
Pubmed

The DAZL family proteins are PABP-binding proteins that regulate translation in germ cells.

DAZ1 DAZ3 DAZ2 DAZ4

3.33e-11644416001084
Pubmed

Cracd Marks the First Wave of Meiosis during Spermatogenesis and Is Mis-Expressed in Azoospermia Mice.

DAZ1 DAZ3 DAZ2 DAZ4

3.33e-11644432962040
Pubmed

Translation of the synaptonemal complex component Sycp3 is enhanced in vivo by the germ cell specific regulator Dazl.

DAZ1 DAZ3 DAZ2 DAZ4

3.33e-11644417526644
Pubmed

Genetic mapping of a male germ cell-expressed gene Tpx-2 to mouse chromosome 17.

DAZ1 DAZ3 DAZ2 DAZ4

3.33e-1164441869307
Pubmed

A gene family required for human germ cell development evolved from an ancient meiotic gene conserved in metazoans.

DAZ1 DAZ3 DAZ2 DAZ4

3.33e-11644411390979
Pubmed

BOULE, a Deleted in Azoospermia Homolog, Is Recruited to Stress Granules in the Mouse Male Germ Cells.

DAZ1 DAZ3 DAZ2 DAZ4

3.33e-11644427632217
Pubmed

The mouse male germ cell-specific gene Tpx-1: molecular structure, mode of expression in spermatogenesis, and sequence similarity to two non-mammalian genes.

DAZ1 DAZ3 DAZ2 DAZ4

3.33e-1164441638086
Pubmed

Spermatogenesis in testes of Dazl null mice after transplantation of wild-type germ cells.

DAZ1 DAZ3 DAZ2 DAZ4

3.33e-11644414611632
Pubmed

Identification of two novel proteins that interact with germ-cell-specific RNA-binding proteins DAZ and DAZL1.

DAZ1 DAZ3 DAZ2 DAZ4

7.77e-11744410857750
Pubmed

The RNA-binding specificity of the mouse Dazl protein.

DAZ1 DAZ3 DAZ2 DAZ4

7.77e-11744411410654
Pubmed

Identification of a novel gene, DZIP (DAZ-interacting protein), that encodes a protein that interacts with DAZ (deleted in azoospermia) and is expressed in embryonic stem cells and germ cells.

DAZ1 DAZ3 DAZ2 DAZ4

7.77e-11744415081113
Pubmed

Sertoli-cell-specific knockout of connexin 43 leads to multiple alterations in testicular gene expression in prepubertal mice.

DAZ1 DAZ3 DAZ2 DAZ4

7.77e-11744422699423
Pubmed

Characterization of the mouse Dazap1 gene encoding an RNA-binding protein that interacts with infertility factors DAZ and DAZL.

DAZ1 DAZ3 DAZ2 DAZ4

7.77e-11744411604102
Pubmed

The Dazh gene is expressed in male and female embryonic gonads before germ cell sex differentiation.

DAZ1 DAZ3 DAZ2 DAZ4

7.77e-1174449588208
Pubmed

DAZL and CPEB1 regulate mRNA translation synergistically during oocyte maturation.

DAZ1 DAZ3 DAZ2 DAZ4

7.77e-11744426826184
Pubmed

Dazl can bind to dynein motor complex and may play a role in transport of specific mRNAs.

DAZ1 DAZ3 DAZ2 DAZ4

7.77e-11744416946704
Pubmed

Fanconi anemia complementation group C is required for proliferation of murine primordial germ cells.

DAZ1 DAZ3 DAZ2 DAZ4

1.55e-10844410951504
Pubmed

Mouse dead end1 acts with Nanos2 and Nanos3 to regulate testicular teratoma incidence.

DAZ1 DAZ3 DAZ2 DAZ4

1.55e-10844432339196
Pubmed

Single-cell transcriptomics reveal temporal dynamics of critical regulators of germ cell fate during mouse sex determination.

DAZ1 DAZ3 DAZ2 DAZ4

1.55e-10844433749946
Pubmed

Hypomethylating therapy in an aggressive stroma-rich model of pancreatic carcinoma.

DAZ1 DAZ3 DAZ2 DAZ4

1.55e-10844423204224
Pubmed

Requirement of the 3'-UTR-dependent suppression of DAZL in oocytes for pre-implantation mouse development.

DAZ1 DAZ3 DAZ2 DAZ4

1.55e-10844429883445
Pubmed

A mammalian germ cell-specific RNA-binding protein interacts with ubiquitously expressed proteins involved in splice site selection.

DAZ1 DAZ3 DAZ2 DAZ4

1.55e-10844410823932
Pubmed

Embryonic poly(A)-binding protein (EPAB) is required for oocyte maturation and female fertility in mice.

DAZ1 DAZ3 DAZ2 DAZ4

1.55e-10844422621333
Pubmed

DAZL mediates a broad translational program regulating expansion and differentiation of spermatogonial progenitors.

DAZ1 DAZ3 DAZ2 DAZ4

1.55e-10844432686646
Pubmed

A preliminary report on the implication of RT-PCR detection of DAZ, RBMY1, USP9Y and Protamine-2 mRNA in testicular biopsy samples from azoospermic men.

DAZ1 DAZ3 DAZ2 DAZ4

1.55e-10844411869379
Pubmed

Dazl deficiency leads to embryonic arrest of germ cell development in XY C57BL/6 mice.

DAZ1 DAZ3 DAZ2 DAZ4

2.79e-10944416310179
Pubmed

Opposing effects of retinoic acid and FGF9 on Nanos2 expression and meiotic entry of mouse germ cells.

DAZ1 DAZ3 DAZ2 DAZ4

2.79e-10944420159962
Pubmed

A Gene Regulatory Program for Meiotic Prophase in the Fetal Ovary.

DAZ1 DAZ3 DAZ2 DAZ4

2.79e-10944426378784
Pubmed

Embryoid bodies from mouse stem cells express oxytocin receptor, Oct-4 and DAZL.

DAZ1 DAZ3 DAZ2 DAZ4

2.79e-10944419695304
Pubmed

The epigenetic modifications and the anterior to posterior characterization of meiotic entry during mouse oogenesis.

DAZ1 DAZ3 DAZ2 DAZ4

2.79e-10944428235998
Pubmed

Mice with Y chromosome deletion and reduced Rbm genes on a heterozygous Dazl1 null background mimic a human azoospermic factor phenotype.

DAZ1 DAZ3 DAZ2 DAZ4

4.65e-101044410601091
Pubmed

Analysis of Uncharacterized mKiaa1211 Expression during Mouse Development and Cardiovascular Morphogenesis.

DAZ1 DAZ3 DAZ2 DAZ4

4.65e-101044431234534
Pubmed

Tesmin transcription is regulated differently during male and female meiosis.

DAZ1 DAZ3 DAZ2 DAZ4

4.65e-101044414648882
Pubmed

MAX controls meiotic entry in sexually undifferentiated germ cells.

DAZ1 DAZ3 DAZ2 DAZ4

4.65e-101044438433229
Pubmed

Knockout mouse model and gametogenic failure.

DAZ1 DAZ3 DAZ2 DAZ4

4.65e-10104449922113
Pubmed

SYCP3-like X-linked 2 is expressed in meiotic germ cells and interacts with synaptonemal complex central element protein 2 and histone acetyltransferase TIP60.

DAZ1 DAZ3 DAZ2 DAZ4

4.65e-101044423810942
Pubmed

The CDY-related gene family: coordinated evolution in copy number, expression profile and protein sequence.

DAZ1 DAZ3 DAZ2 DAZ4

4.65e-101044412837688
Pubmed

NANOS2 suppresses the cell cycle by repressing mTORC1 activators in embryonic male germ cells.

DAZ1 DAZ3 DAZ2 DAZ4

7.30e-101144434401671
Pubmed

ZGLP1 is a determinant for the oogenic fate in mice.

DAZ1 DAZ3 DAZ2 DAZ4

1.09e-091244432054698
Pubmed

Germ cell-intrinsic and -extrinsic factors govern meiotic initiation in mouse embryos.

DAZ1 DAZ3 DAZ2 DAZ4

1.09e-091244419074348
Pubmed

Licensing of primordial germ cells for gametogenesis depends on genital ridge signaling.

DAZ1 DAZ3 DAZ2 DAZ4

1.09e-091244425739037
CytobandYq11.223

DAZ1 DAZ3 DAZ2 DAZ4

2.01e-0693444Yq11.223
CytobandEnsembl 112 genes in cytogenetic band chrYq11

DAZ1 DAZ3 DAZ2 DAZ4

2.26e-04311444chrYq11
CytobandEnsembl 112 genes in cytogenetic band chr1q31

ASPM PTGS2

2.38e-0375442chr1q31
CytobandEnsembl 112 genes in cytogenetic band chr6q23

EYA4 VNN2

5.87e-03119442chr6q23
GeneFamilyRNA binding motif containing

RBM5 DAZ1 DAZ3 DAZ2 DAZ4

1.42e-05213275725
GeneFamilyProtein tyrosine phosphatases, receptor type

PTPRS PTPRT

4.43e-0421272813
CoexpressionTESAR_JAK_TARGETS_MOUSE_ES_D3_DN

DAZ1 DAZ3 DAZ2 DAZ4

3.38e-0912444MM742
CoexpressionSASAI_TARGETS_OF_CXCR6_AND_PTCH1_DN

DAZ1 DAZ3 DAZ2 DAZ4

3.38e-0912444MM781
CoexpressionWAGSCHAL_EHMT2_TARGETS_UP

DAZ1 DAZ3 DAZ2 DAZ4

5.97e-0823444MM1293
CoexpressionMATZUK_SPERMATOGONIA

DAZ1 DAZ3 DAZ2 DAZ4

2.10e-0731444MM765
CoexpressionCHEN_ETV5_TARGETS_TESTIS

DAZ1 DAZ3 DAZ2 DAZ4

2.73e-0733444MM701
CoexpressionJACKSON_DNMT1_TARGETS_UP

DAZ1 DAZ3 DAZ2 DAZ4 PTGS2

4.91e-0793445MM1185
CoexpressionMADAN_DPPA4_TARGETS

DAZ1 DAZ3 DAZ2 DAZ4

1.33e-0586444MM1312
CoexpressionGSE17721_LPS_VS_CPG_16H_BMDC_DN

RBM5 TFG PRICKLE1 VNN2 DICER1

2.10e-05200445M4009
CoexpressionMCCABE_BOUND_BY_HOXC6

DAZ1 DAZ3 DAZ2 MYO9B DAZ4 AGBL3

1.15e-04461446M6376
Drugboron trichloride

DAZ1 DAZ3 DAZ2 DAZ4

1.81e-106444CID000025135
Drugdazmegrel

DAZ1 DAZ3 DAZ2 DAZ4 PTGS2

2.43e-1019445CID000053555
DrugVistar

DAZ1 DAZ3 DAZ2 DICER1 DAZ4

7.69e-0936445CID000040896
Drugdesmethylazelastine

DAZ1 DAZ3 DAZ2 DAZ4

2.17e-0816444CID000162558
DrugYM 026

DAZ1 DAZ3 DAZ2 DAZ4

4.60e-0819444CID000004443
Drugridogrel

DAZ1 DAZ3 DAZ2 DAZ4 PTGS2

5.18e-0852445CID005362391
DrugAZFd

DAZ1 DAZ3 DAZ2 DAZ4

1.05e-0723444CID000196489
Drugdansylaziridine

DAZ1 DAZ3 DAZ2 DAZ4

1.05e-0723444CID000104008
Drugazelastine

DAZ1 DAZ3 DAZ2 DAZ4 PTGS2

3.11e-0774445CID000002267
Drugd-gluconhydroximo-1,5-lactam

DAZ1 DAZ3 DAZ2 DAZ4

3.67e-0731444CID000003479
Drug3-bromo-7-nitroindazole

DAZ1 DAZ3 DAZ2 DAZ4

6.83e-0736444CID000001649
DrugBW755C

DAZ1 DAZ3 DAZ2 DAZ4 PTGS2

9.77e-0793445CID000047795
Drugbipy

DAZ1 DAZ3 DAZ2 DAZ4 PTGS2

1.20e-0697445CID000001474
Drugmolybdenum disulfide

DAZ1 DAZ3 DAZ2 DAZ4

1.42e-0643444CID000014823
Drug2-chlorodideoxyadenosine

DAZ1 DAZ3 DAZ2 DAZ4

1.42e-0643444CID000072194
Drugpropham

DAZ1 DAZ3 DAZ2 DAZ4

1.56e-0644444CID000024685
DrugTXB2 (thromboxane B2

DAZ1 DAZ3 DAZ2 DAZ4 PTGS2

3.17e-06118445CID000005461
Drugazafagomine

DAZ1 DAZ3 DAZ2 DAZ4

4.45e-0657444CID011957435
DrugNSC56408

DAZ1 DAZ3 DAZ2 DAZ4

6.24e-0662444CID000005604
Drugkt S

DAZ1 DAZ3 DAZ2 DAZ4

8.01e-0666444CID006399216
Drugp11-13

DAZ1 DAZ3 DAZ2 DAZ4

1.33e-0575444CID000015759
DrugCrotamiton [483-63-6]; Up 200; 19.6uM; MCF7; HT_HG-U133A

MYO3A CEACAM21 VNN2 DICER1 GIMAP6

3.71e-051964455689_UP
DrugHeliotrine [303-33-3]; Down 200; 12.8uM; MCF7; HT_HG-U133A

OLFML2A GREB1 MYO9B PTPRS DICER1

3.71e-051964454739_DN
DrugAC1O0UZ8

TFG DICER1 PTGS2

5.42e-0538443CID006102762
Drugthromboxane

DAZ1 DAZ3 DAZ2 DAZ4 PTGS2

6.86e-05223445CID000114873
Drugcarbonyl sulfide

DAZ1 DAZ3 DAZ2 DAZ4

7.42e-05116444CID000010039
Drugangiotensin (1-7)

PRCP PREP PTGS2

1.31e-0451443CID000123805
DiseaseMale sterility due to Y-chromosome deletions

DAZ1 DAZ3 DAZ2 DAZ4

3.00e-108444C2931163
DiseasePartial chromosome Y deletion

DAZ1 DAZ3 DAZ2 DAZ4

3.00e-108444C1507149
DiseaseSpermatogenic Failure, Nonobstructive, Y-Linked

DAZ1 DAZ3 DAZ2

1.71e-0616443C1839071
DiseaseSPERMATOGENIC FAILURE, Y-LINKED, 2

DAZ1 DAZ3 DAZ2

1.71e-0616443415000
DiseaseSpermatogenic failure, Y-linked, 2

DAZ1 DAZ3 DAZ2

1.71e-0616443cv:C1839071
Diseaseprostate carcinoma in situ (is_marker_for)

CARM1 FGF6 PTGS2

9.87e-0628443DOID:8634 (is_marker_for)
Diseaseinferior parietal cortex volume measurement

GREB1 PRICKLE1

3.66e-0419442EFO_0010307
DiseaseDiGeorge syndrome (implicated_via_orthology)

HOXA3 DICER1

3.66e-0419442DOID:11198 (implicated_via_orthology)
Diseasefatty liver disease (implicated_via_orthology)

TRAPPC11 PTGS2

9.83e-0431442DOID:9452 (implicated_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
YTYTNLQEYLSGINN

AGBL3

301

Q8NEM8
YGRYLQQFNTNFDEN

CFAP54

151

Q96N23
DTGYYNLQVTYRNSQ

CEACAM21

116

Q3KPI0
YNVFNFQNVGGKYSY

GRM3

466

Q14832
NNYNAYESDLYQGTY

FGF6

166

P10767
SYSIQNLYSYENQPQ

DICER1

1216

Q9UPY3
FQVATGYQFPVYNYQ

DAZ2

296

Q13117
FQVATGYQFPVYNYQ

DAZ3

296

Q9NR90
IQNYYHAYKAQVNQR

ASPM

1781

Q8IZT6
YLQFAYYNIGNYTQA

P3H1

306

Q32P28
ICQQGNFQYENFFNY

INTS10

611

Q9NVR2
SQLGNIRQLFFYNNY

LRRD1

231

A4D1F6
YQNSQSVSRAYEQYG

GREB1

411

Q4ZG55
YPYQAANGFAYNANQ

HOXA3

16

O43365
AVQYFQFYGYLSQQQ

CARM1

146

Q86X55
NIFQALNVYYNYSGQ

PRCP

326

P42785
QKYNYQQFIYNNSIL

PTGS2

386

P35354
VQFQQYAAQQYPGNY

ACBD3

256

Q9H3P7
YAQYSQDYQQFYQQQ

RBM5

371

P52756
YINANYVDGYRCQNA

PTPRS

1446

Q13332
NLTVQYQYVFNQQQY

PTPRT

421

O14522
YFYFYNTGLQNQRVL

PREP

86

P48147
IQAYIQNADLYGQYA

PRICKLE1

721

Q96MT3
FGQNQYAQYYSASTY

EYA4

276

O95677
FQVATGYQFPVYNYQ

DAZ1

626

Q9NQZ3
GNVFMYYGLSNFYQN

TMEM30A

116

Q9NV96
YTNSLFQNYQNLYLQ

KIF5A

946

Q12840
FQVATGYQFPVYNYQ

DAZ4

461

Q86SG3
TQFQYNYEYLGNSGR

DNAH2

1761

Q9P225
SYQYQVQGFPSYFLQ

HELB

101

Q8NG08
VVYNGSLYFNKYQSN

OLFM3

296

Q96PB7
YAVDTYNQQEGQVAY

OLFML2A

586

Q68BL7
YQQYAQQWNQYYQNQ

HNRNPUL1

816

Q9BUJ2
YSNKAYQYTQQNFRL

GIMAP6

231

Q6P9H5
VQFLNQYGFNYNKFL

PNLDC1

101

Q8NA58
YQGESNINYNTDLYN

SIAE

276

Q9HAT2
QNPDYNFFNNYKTYR

ST6GAL1

271

P15907
QEYLSLNNWNANYNY

SPIC

221

Q8N5J4
LNNWNANYNYTYANY

SPIC

226

Q8N5J4
NGYFQYNTNVVYNTE

VNN2

156

O95498
IQTQNPGFYYQQAAY

TRAPPC11

341

Q7Z392
QQYGIQYSASYSQQT

TFG

266

Q92734
YYIQNGIQSFMQNYS

PRKDC

3101

P78527
QLCINIANEQIQYYY

MYO3A

731

Q8NEV4
IANEQIQYYYNQHVF

MYO3A

736

Q8NEV4
CINYANEQLQYYFNQ

MYO9B

536

Q13459