Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionprotein serine kinase activity

HIPK3 PIKFYVE STK36 MYO3A ATM MAP3K19

9.10e-05363416GO:0106310
GeneOntologyMolecularFunctionprotein kinase activity

HIPK3 PIKFYVE NRG2 STK36 MYO3A ATM MAP3K19

1.97e-04600417GO:0004672
GeneOntologyMolecularFunctionprotein serine/threonine kinase activity

HIPK3 PIKFYVE STK36 MYO3A ATM MAP3K19

2.78e-04446416GO:0004674
GeneOntologyMolecularFunctionphosphotransferase activity, alcohol group as acceptor

HIPK3 PIKFYVE NRG2 STK36 MYO3A ATM MAP3K19

5.42e-04709417GO:0016773
GeneOntologyMolecularFunctiontransferase activity, transferring phosphorus-containing groups

HIPK3 PIKFYVE NRG2 STK36 MYO3A ATM REV3L MAP3K19

5.52e-04938418GO:0016772
GeneOntologyMolecularFunctionminus-end-directed microtubule motor activity

DNAH2 DNAH1

6.16e-0418412GO:0008569
GeneOntologyMolecularFunctionkinase activity

HIPK3 PIKFYVE NRG2 STK36 MYO3A ATM MAP3K19

8.43e-04764417GO:0016301
GeneOntologyMolecularFunctionphosphatidylinositol kinase activity

PIKFYVE ATM

1.30e-0326412GO:0052742
GeneOntologyMolecularFunctiondynein light intermediate chain binding

DNAH2 DNAH1

1.50e-0328412GO:0051959
GeneOntologyMolecularFunctioncytoskeletal motor activity

DNAH2 MYO3A DNAH1

1.82e-03118413GO:0003774
GeneOntologyMolecularFunctiondynein intermediate chain binding

DNAH2 DNAH1

2.62e-0337412GO:0045505
GeneOntologyMolecularFunctionlipid kinase activity

PIKFYVE ATM

3.21e-0341412GO:0001727
GeneOntologyMolecularFunctionepidermal growth factor receptor binding

NRG2 ATXN2

3.21e-0341412GO:0005154
GeneOntologyMolecularFunction4 iron, 4 sulfur cluster binding

REV3L PRIM2

4.19e-0347412GO:0051539
GeneOntologyCellularComponentinner dynein arm

DNAH2 DNAH1

1.84e-0410432GO:0036156
DomainLRRC37AB_C

LRRC37A LRRC37A3 LRRC37A2

4.54e-084433PF14914
DomainLRRC37_N

LRRC37A LRRC37A3 LRRC37A2

4.54e-084433IPR032754
DomainLRRC37AB_C

LRRC37A LRRC37A3 LRRC37A2

4.54e-084433IPR029423
DomainLRRC37

LRRC37A LRRC37A3 LRRC37A2

4.54e-084433PF15779
DomainLRRC37A/B-like

LRRC37A LRRC37A3 LRRC37A2

4.54e-084433IPR015753
DomainDynein_heavy_chain_D4_dom

DNAH2 DNAH1

4.63e-0414432IPR024317
DomainDynein_HC_stalk

DNAH2 DNAH1

4.63e-0414432IPR024743
DomainDynein_heavy_dom-2

DNAH2 DNAH1

4.63e-0414432IPR013602
DomainDHC_N2

DNAH2 DNAH1

4.63e-0414432PF08393
DomainMT

DNAH2 DNAH1

4.63e-0414432PF12777
DomainAAA_8

DNAH2 DNAH1

4.63e-0414432PF12780
DomainATPase_dyneun-rel_AAA

DNAH2 DNAH1

4.63e-0414432IPR011704
DomainAAA_5

DNAH2 DNAH1

4.63e-0414432PF07728
DomainDHC_fam

DNAH2 DNAH1

5.33e-0415432IPR026983
DomainDynein_heavy_dom

DNAH2 DNAH1

5.33e-0415432IPR004273
DomainDynein_heavy

DNAH2 DNAH1

5.33e-0415432PF03028
DomainHECT

SMURF1 HERC1

1.75e-0327432PF00632
DomainHECTc

SMURF1 HERC1

1.75e-0327432SM00119
DomainHECT_dom

SMURF1 HERC1

1.75e-0327432IPR000569
DomainHECT

SMURF1 HERC1

1.75e-0327432PS50237
DomainLeu-rich_rpt

NLRP14 LRRC37A LRRC37A3 LRRC37A2

3.43e-03271434IPR001611
Domain-

NLRP14 LRRC37A LRRC37A3 LRRC37A2

6.24e-033214343.80.10.10
DomainL_dom-like

NLRP14 LRRC37A LRRC37A3 LRRC37A2

6.72e-03328434IPR032675
DomainLRR_8

LRRC37A LRRC37A3 LRRC37A2

7.12e-03171433PF13855
DomainLeu-rich_rpt_typical-subtyp

LRRC37A LRRC37A3 LRRC37A2

7.82e-03177433IPR003591
DomainLRR_TYP

LRRC37A LRRC37A3 LRRC37A2

7.82e-03177433SM00369
DomainKinase-like_dom

HIPK3 STK36 MYO3A ATM MAP3K19

7.83e-03542435IPR011009
DomainZnf_CCCH

ZC3H12C MBNL3

7.89e-0358432IPR000571
DomainZF_C3H1

ZC3H12C MBNL3

7.89e-0358432PS50103
DomainSer/Thr_kinase_AS

HIPK3 STK36 MYO3A MAP3K19

9.01e-03357434IPR008271
Pubmed

Primate segmental duplication creates novel promoters for the LRRC37 gene family within the 17q21.31 inversion polymorphism region.

LRRC37A LRRC37A3 LRRC37A2

7.55e-09444322419166
Pubmed

Evolutionary dynamism of the primate LRRC37 gene family.

LRRC37A LRRC37A3 LRRC37A2

2.25e-071044323064749
Pubmed

The Protexin complex counters resection on stalled forks to promote homologous recombination and crosslink repair.

REV3L SCAI

1.56e-06244234597596
Pubmed

A novel T cell subset with trans-rearranged Vγ-Cβ TCRs shows Vβ expression is dispensable for lineage choice and MHC restriction.

ATM FOXP3

4.69e-06344224307734
Pubmed

Comprehensive analysis of differential gene expression profiles on D-galactosamine-induced acute mouse liver injury and regeneration.

ATM PRIM2

9.37e-06444216962228
Pubmed

Role of estrogen receptor in breast cancer cell gene expression.

MEIS1 FOXP3

1.56e-05544227035558
Pubmed

Isolation of several human axonemal dynein heavy chain genes: genomic structure of the catalytic site, phylogenetic analysis and chromosomal assignment.

DNAH2 DNAH1

3.27e-0574429256245
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

PIKFYVE STK36 ARHGEF19 SFI1 REV3L HERC1 ADAMTS7 IFRD2

6.49e-05110544835748872
Pubmed

Dynein and kinesin regulate stress-granule and P-body dynamics.

DNAH2 DNAH1

6.99e-051044219825938
Pubmed

Inhibition of RIF1 by SCAI Allows BRCA1-Mediated Repair.

REV3L SCAI

1.02e-041244228700933
Pubmed

Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene.

DNAH2 DNAH1

1.41e-04144429373155
Pubmed

HECT E3 Ubiquitin Ligase Itch Functions as a Novel Negative Regulator of Gli-Similar 3 (Glis3) Transcriptional Activity.

HIPK3 SMURF1

1.41e-041444226147758
Pubmed

Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

SFI1 LRRC37A LRRC37A3

3.24e-041054439628581
Pubmed

PEG3 binds to H19-ICR as a transcriptional repressor.

PLAGL1 MSL3

3.56e-042244227824289
Pubmed

The absence of Prep1 causes p53-dependent apoptosis of mouse pluripotent epiblast cells.

ATM MEIS1

4.24e-042444220826531
Pubmed

System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.

SMURF1 HERC1

4.99e-042644226949039
Pubmed

Insights into developmental mechanisms and cancers in the mammalian intestine derived from serial analysis of gene expression and study of the hepatoma-derived growth factor (HDGF).

PLAGL1 PTBP1

8.55e-043444215604097
Pubmed

Linking functions: an additional role for an intrinsically disordered linker domain in the transcriptional coactivator CBP.

HIPK3 SP100

1.07e-033844228680062
Pubmed

Image-based genome-wide siRNA screen identifies selective autophagy factors.

SMURF1 SFRP4 ADAMTS7

1.08e-0315944322020285
Cytoband19q13.41

ZNF611 ZNF808

2.57e-037844219q13.41
Cytoband17q21.31

LRRC37A LRRC37A2

2.84e-038244217q21.31
GeneFamilyDyneins, axonemal

DNAH2 DNAH1

3.10e-0417282536
GeneFamilyZinc fingers CCCH-type

ZC3H12C MBNL3

1.33e-033528273
CoexpressionGSE11057_EFF_MEM_VS_CENT_MEM_CD4_TCELL_DN

SFI1 ATM HERC1 LRRC37A2 FOXP3

1.60e-05189445M3112
CoexpressionGSE3982_EFF_MEMORY_CD4_TCELL_VS_TH2_UP

NRG2 SP100 AHCYL2 HERC1 MSL3

2.00e-05198445M5580
ToppCellBAL-Severe-cDC_6|Severe / Compartment, Disease Groups and Clusters

ARHGEF19 REV3L ATP7B LRRC37A3

7.53e-061304344104d1e10609331b67db3b85c63537aec58b1713
ToppCellLPS-antiTNF-Hematopoietic_Meg-Ery-Mes-Epi-like-Erythroid|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PLAGL1 MYO3A SFRP4 FOXP3

9.26e-061374348e2fa2ef8becace96a68bb85c002329110902fbb
ToppCellT_cells-Treg_cells|T_cells / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues

PLAGL1 FAM184A ZC3H12C FOXP3

9.53e-0613843435880e23ef317862891b54ac6a2265ca03b1d12a
ToppCell3'-Distal_airway-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DNAH2 STK36 MYO3A MAP3K19

2.32e-05173434c3762655caa79ac4879876f470d32578a3c93b01
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Multiciliated_(nasal)-Multiciliated_(nasal)_L.0.3.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DNAH2 STK36 MAP3K19 DNAH1

2.59e-051784343b12db04006db6e94fc45649a4b3a63b92f21a61
ToppCell10x5'-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8|lymph-node_spleen / Manually curated celltypes from each tissue

FAM184A SFI1 ATM HERC1

3.48e-0519243447646d7e4990be85072987f92bf18d52f8da752e
ToppCellTracheal-10x5prime-Epithelial-Epi_airway_ciliated-Deuterosomal|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

LRRC37A LRRC37A3 MAP3K19 DNAH1

3.85e-051974346e4a411ef823ce9e16f420e185e21fa19d13af34
ToppCellmild-low-quality_cells|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

SP100 SFI1 ATM HERC1

4.00e-05199434f0b0097df0026496470a80d8cc9375ffd8389b00
ToppCellLPS_IL1RA_TNF-Epithelial_airway-airway_epithelial-Ciliated|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

DNAH2 FAM184A MAP3K19 DNAH1

4.08e-0520043496701a4d57753f5ec0dd5c7550054bbcc946bc5f
DrugMeticrane [1084-65-7]; Down 200; 14.6uM; MCF7; HT_HG-U133A

ZNF611 SP100 AHCYL2 ATM ATP7B MSL3

2.03e-061964465984_DN
DrugMedrysone [2668-66-8]; Down 200; 11.6uM; MCF7; HT_HG-U133A

ZNF611 HIPK3 AHCYL2 ATM ALDH1L1 MSL3

2.15e-061984463603_DN
DrugMethocarbamol [532-03-6]; Down 200; 16.6uM; MCF7; HT_HG-U133A

SMURF1 PLAGL1 AHCYL2 ATM MBNL3 MSL3

2.15e-061984462274_DN
DrugPromethazine hydrochloride [58-33-3]; Down 200; 12.4uM; MCF7; HT_HG-U133A

PLAGL1 SP100 SFI1 ATM NPY5R MSL3

2.21e-061994466477_DN
Drug3-alpha-Hydroxy-5-beta-androstan-17-one [53-42-9]; Down 200; 13.8uM; PC3; HT_HG-U133A

ZNF611 HIPK3 SMURF1 ATM PTBP1

3.28e-051914454298_DN
Drugestradiol, USP; Up 200; 0.01uM; MCF7; HT_HG-U133A

SMURF1 AHCYL2 SFI1 NPY5R MBNL3

3.37e-051924455238_UP
DrugHesperidin [520-26-3]; Up 200; 6.6uM; MCF7; HT_HG-U133A

SP100 SFI1 ATM SFRP4 MSL3

3.62e-051954455313_UP
Drugclozapine; Up 200; 10uM; MCF7; HT_HG-U133A

SFI1 SFRP4 MBNL3 MAP3K19 MSL3

3.71e-051964455226_UP
DrugPropafenone hydrochloride [34183-22-7]; Down 200; 10.6uM; MCF7; HT_HG-U133A

SMURF1 SFI1 ATM MBNL3 MSL3

3.81e-051974455437_DN
DrugAmpicillin trihydrate [7177-48-2]; Up 200; 10uM; MCF7; HT_HG-U133A

ZNF611 SFI1 ATM SFRP4 MSL3

3.81e-051974451530_UP
DrugChenodiol [474-25-9]; Up 200; 10.2uM; MCF7; HT_HG-U133A

HIPK3 NRG2 PLAGL1 SFI1 FOXP3

3.90e-051984457433_UP
Drug(-)-MK 801 hydrogen maleate [77086-19-2]; Down 200; 11.8uM; MCF7; HT_HG-U133A

SP100 AHCYL2 ATM ATXN2 MSL3

3.99e-051994456458_DN
DrugDipivefrin hydrochloride [64019-93-8]; Down 200; 10.4uM; MCF7; HT_HG-U133A

HIPK3 SFI1 ATM ALDH1L1 MSL3

3.99e-051994452744_DN
DrugLincomycin hydrochloride [859-18-7]; Up 200; 9uM; MCF7; HT_HG-U133A

HIPK3 SP100 ALDH1L1 ADAMTS7 FOXP3

3.99e-051994455992_UP
DrugVancomycin hydrochloride [1404-93-9]; Down 200; 2.6uM; PC3; HT_HG-U133A

SMURF1 SP100 FAM184A SFRP4 MSL3

4.09e-052004454598_DN
DrugBenzylpenicillin sodium [69-57-8]; Up 200; 11.2uM; MCF7; HT_HG-U133A

HIPK3 SP100 AHCYL2 ADAMTS7 FOXP3

4.09e-052004456839_UP
Drug2'-deoxyadenosine 5'-triphosphate

AHCYL2 NLRP14 REV3L PRIM2

5.82e-05109444CID000000622
DiseaseMammary Carcinoma, Human

ATM LRRC37A ATP7B MEIS1 LRRC37A2 FOXP3

1.23e-04525446C4704874
DiseaseMammary Neoplasms, Human

ATM LRRC37A ATP7B MEIS1 LRRC37A2 FOXP3

1.23e-04525446C1257931
DiseaseMammary Neoplasms

ATM LRRC37A ATP7B MEIS1 LRRC37A2 FOXP3

1.25e-04527446C1458155
DiseaseBreast Carcinoma

ATM LRRC37A ATP7B MEIS1 LRRC37A2 FOXP3

1.40e-04538446C0678222
Diseaseserum non-albumin protein measurement

DNAH2 SP100 UGT3A2 ATXN2 MAP3K19

1.96e-04361445EFO_0004568
Diseaseglucose measurement

MYO3A LRRC37A HERC1 LRRC37A3 ATXN2

2.48e-04380445EFO_0004468
Diseaseleukemia (implicated_via_orthology)

ATM MEIS1

3.66e-0419442DOID:1240 (implicated_via_orthology)
DiseaseOvarian Serous Adenocarcinoma

STK36 MYO3A

5.39e-0423442C1335177
Diseasehematocrit

DNAH2 STK36 AHCYL2 PTBP1 ATXN2 MEIS1 MAP3K19

6.87e-041011447EFO_0004348
Diseaseeye measurement

HERC1 ATXN2

7.45e-0427442EFO_0004731
DiseaseMalignant neoplasm of breast

NLRP14 ATM LRRC37A ATP7B MEIS1 LRRC37A2 FOXP3

9.79e-041074447C0006142
Diseaseleft ventricular mass index

AHCYL2 MEIS1

1.18e-0334442EFO_0009290
DiseaseKartagener Syndrome

STK36 DNAH1

1.25e-0335442C0022521
DiseasePolynesian Bronchiectasis

STK36 DNAH1

1.25e-0335442C4317124
DiseaseCiliary Dyskinesia, Primary, 1, With Or Without Situs Inversus

STK36 DNAH1

1.25e-0335442C4551906
Diseaseserum alanine aminotransferase measurement

DNAH2 ARHGEF19 ALDH1L1 PTBP1 ADAMTS7 ATXN2

1.74e-03869446EFO_0004735
DiseasePrimary Ciliary Dyskinesia

STK36 DNAH1

2.25e-0347442C4551720
DiseaseColorectal Carcinoma

ZNF217 UGT3A2 SFRP4 ALDH1L1 ATP7B

3.79e-03702445C0009402
Diseasebreast carcinoma (is_marker_for)

ATM ATP7B

4.39e-0366442DOID:3459 (is_marker_for)

Protein segments in the cluster

PeptideGeneStartEntry
LAQRNPNAHHLDHKM

ATP7B

631

P35670
LRHNHHQELAAAKME

FAM184A

836

Q8NB25
QKSINMKGDAHPLHH

ADAMTS7

321

Q9UKP4
DPHAARSMQPVHHLN

MEIS1

26

O00470
QLLHGQHMKHQFLLR

ARHGEF19

671

Q8IW93
HGMQFLHKLILNHNP

LRRC37A3

961

O60309
HGMQFLHKLILNHNP

LRRC37A2

961

A6NM11
HGMQFLHKLILNHNP

LRRC37A

961

A6NMS7
HLQALLQDRPHFMHQ

FOXP3

91

Q9BZS1
QRQDQHHQSAMMHPA

ATXN2

1006

Q99700
RKNHEHMSKNHDVAQ

HERC1

2486

Q15751
QMHNHLRQNMCPAHQ

NRG2

436

O14511
NERPRHHHVMPHANM

MSL3

226

Q8N5Y2
NMKHLLDFPHSNHVK

HIPK3

526

Q9H422
PCMRQLHKALRENHH

PRIM2

286

P49643
ANHNHMMALLQQLLH

PIKFYVE

611

Q9Y2I7
NKLMPRHLDHQHPQT

DNAH1

216

Q9P2D7
LNNLISRISMDHPHH

ATM

2541

Q13315
AHLQARLKAAHHQMN

MBNL3

236

Q9NUK0
SGMHHHLQNNELLRD

IFRD2

441

Q12894
RMNKDNNALRSTHHP

DNAH2

1486

Q9P225
AQLHRLKMDQACHLH

FAM167B

106

Q9BTA0
PVHQENDKHKMNSHR

MAP3K19

521

Q56UN5
RQKLMRADLHHQHSV

SFI1

636

A8K8P3
HLKNHLQTHDPNKMA

PLAGL1

76

Q9UM63
PQASAMKRSDPHHQH

AHCYL2

81

Q96HN2
MKRSDPHHQHQRHRD

AHCYL2

86

Q96HN2
HMIKHPISNNLTANH

NPY5R

141

Q15761
MPHIQHLKGAHSKNL

PRORSD1P

36

A6NEY8
SNHNRMGRHKPHLAL

NEPRO

71

Q6NW34
DPRLHHIMNHQCQLK

SMURF1

336

Q9HCE7
LHSHRILHRDMKPQN

STK36

116

Q9NRP7
HGPQNHHAHLVKLME

ALDH1L1

746

O75891
KDSPFIHMHRHPNEN

REV3L

686

O60673
IHMHRHPNENTLGKN

REV3L

691

O60673
RMPNHLHHSTQENAI

SFRP4

41

Q6FHJ7
ANEMNHLPAHSHDLQ

SP100

21

P23497
QHDHRHAGNKPIKDQ

ZNF808

141

Q8N4W9
RNQSHKEMHCLHPGD

SCAI

406

Q8N9R8
HSEDLNKHVLMQHRP

ZNF217

76

O75362
QHDHRHAGNKPIKDQ

ZNF611

141

Q8N823
LEENLKCQHMHPHSR

ZC3H12C

656

Q9C0D7
LQDHGHNVTMLNHKR

UGT3A2

46

Q3SY77
QAQLAMSHLNGHKLH

PTBP1

386

P26599
DKSAMNILHHELRHP

NLRP14

686

Q86W24
LHEALMGLQHLHNNK

MYO3A

131

Q8NEV4
MGLQHLHNNKTIHRD

MYO3A

136

Q8NEV4