Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	nuclear import signal receptor activity	IPO5 IPO4	5.25e-04	20	34	2	GO:0061608
GeneOntologyMolecularFunction	nuclear localization sequence binding	IPO5 IPO4	9.62e-04	27	34	2	GO:0008139
GeneOntologyMolecularFunction	nucleocytoplasmic carrier activity	IPO5 IPO4	1.35e-03	32	34	2	GO:0140142
Domain	NBPF	NBPF15 NBPF11 NBPF14 NBPF9	3.80e-09	11	36	4	PS51316
Domain	DUF1220	NBPF15 NBPF11 NBPF14 NBPF9	3.80e-09	11	36	4	PF06758
Domain	NBPF_dom	NBPF15 NBPF11 NBPF14 NBPF9	3.80e-09	11	36	4	IPR010630
Domain	DUF1220	NBPF15 NBPF11 NBPF9	5.48e-07	9	36	3	SM01148
Domain	IMPORTIN_B_NT	IPO5 IPO4	3.24e-04	14	36	2	PS50166
Domain	Importin-beta_N	IPO5 IPO4	4.82e-04	17	36	2	IPR001494
Domain	-	IPO5 IPO4 HECTD1 AGTPBP1	8.49e-04	222	36	4	1.25.10.10
Domain	ARM-like	IPO5 IPO4 HECTD1 AGTPBP1	1.75e-03	270	36	4	IPR011989
Domain	HEAT	IPO5 IPO4	3.85e-03	48	36	2	PF02985
Domain	ARM-type_fold	IPO5 IPO4 HECTD1 AGTPBP1	3.97e-03	339	36	4	IPR016024
Domain	HEAT	IPO5 IPO4	5.58e-03	58	36	2	IPR000357
Domain	CH	EHBP1 MAPRE3	8.03e-03	70	36	2	PF00307
Domain	HEAT_REPEAT	IPO5 IPO4	8.03e-03	70	36	2	PS50077
Domain	-	EHBP1 MAPRE3	8.26e-03	71	36	2	1.10.418.10
Domain	CH	EHBP1 MAPRE3	8.71e-03	73	36	2	PS50021
Domain	CH-domain	EHBP1 MAPRE3	9.18e-03	75	36	2	IPR001715
Pubmed	A novel gene family NBPF: intricate structure generated by gene duplications during primate evolution.	NBPF10 NBPF8 NBPF19 NBPF15 NBPF11 NBPF14 NBPF9	2.12e-16	21	41	7	16079250
Pubmed	Evolutionary history and genome organization of DUF1220 protein domains.	NBPF8 NBPF15 NBPF14 NBPF9	3.47e-10	10	41	4	22973535
Pubmed	New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing.	NBPF10 NBPF8 NBPF15 NBPF11 HECTD1 NBPF14 NBPF9 U2SURP AGTPBP1	7.10e-09	513	41	9	25798074
Pubmed	Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes?	NBPF10 NBPF8 NBPF11 NBPF14 CEP164 NBPF9	4.87e-08	170	41	6	23314748
Pubmed	Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.	PAXIP1 ZHX3 HIVEP1 PBRM1 TAF7 U2SURP	7.10e-07	268	41	6	33640491
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	GNL2 IPO5 PBRM1 IPO4 HECTD1 PCM1 U2SURP	1.03e-05	653	41	7	22586326
Pubmed	Recognition Elements in the Histone H3 and H4 Tails for Seven Different Importins.	IPO5 IPO4	1.35e-05	5	41	2	27528606
Pubmed	The Epigenetic Factor Landscape of Developing Neocortex Is Regulated by Transcription Factors Pax6→ Tbr2→ Tbr1.	MLLT3 CHD6 PBRM1 POLE3	3.55e-05	157	41	4	30186101
Pubmed	Importin 8 mediates m7G cap-sensitive nuclear import of the eukaryotic translation initiation factor eIF4E.	IPO5 IPO4	3.78e-05	8	41	2	27114554
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	GNL2 IPO5 ZHX3 CHD6 HIVEP1 PBRM1	7.44e-05	608	41	6	36089195
Pubmed	BAP1 induces cell death via interaction with 14-3-3 in neuroblastoma.	IPO5 IPO4	8.88e-05	12	41	2	29686263
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	PAXIP1 ZHX3 NBPF15 CHD6 HIVEP1 PBRM1	9.69e-05	638	41	6	31182584
Pubmed	Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.	PAXIP1 IPO5 KIF21B IGBP1 PBRM1 POLE3 HECTD1 PCM1	1.37e-04	1327	41	8	32694731
Pubmed	C2cd3 is critical for centriolar distal appendage assembly and ciliary vesicle docking in mammals.	CEP164 PCM1	1.41e-04	15	41	2	24469809
Pubmed	USP45 and Spindly are part of the same complex implicated in cell migration.	IPO5 PBRM1 PCM1 U2SURP	1.69e-04	235	41	4	30258100
Pubmed	The CP110-interacting proteins Talpid3 and Cep290 play overlapping and distinct roles in cilia assembly.	CEP164 PCM1	2.29e-04	19	41	2	24421332
Pubmed	Insights into the ubiquitin-proteasome system of human embryonic stem cells.	HECTD1 PCM1 U2SURP AGTPBP1	2.83e-04	269	41	4	29511261
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	GNL2 KIF21B ZHX3 PLCB4 U2SURP	2.86e-04	497	41	5	36774506
Pubmed	TWIST1 and chromatin regulatory proteins interact to guide neural crest cell differentiation.	GNL2 CHD6 PBRM1	2.93e-04	109	41	3	33554859
Pubmed	Evidence for genes on chromosome 2 contributing to alcohol dependence with conduct disorder and suicide attempts.	EHBP1 ERMN	3.38e-04	23	41	2	20468071
Pubmed	C16orf72/HAPSTR1 is a molecular rheostat in an integrated network of stress response pathways.	IPO5 IPO4 U2SURP	3.79e-04	119	41	3	35776542
Pubmed	siRNA screening identifies differences in the Fanconi anemia pathway in BALB/c-Trp53+/- with susceptibility versus C57BL/6-Trp53+/- mice with resistance to mammary tumors.	PAXIP1 POLE3	4.33e-04	26	41	2	23435420
Pubmed	Characterization of carbonic anhydrase IX interactome reveals proteins assisting its nuclear localization in hypoxic cells.	IPO5 IPO4	4.33e-04	26	41	2	23181366
Pubmed	The E3 ubiquitin ligase FBXL6 controls the quality of newly synthesized mitochondrial ribosomal proteins.	GNL2 IPO5 IPO4 HECTD1 AGTPBP1	4.44e-04	547	41	5	37267103
Pubmed	KSHV episome tethering sites on host chromosomes and regulation of latency-lytic switch by CHD4.	IGBP1 TAF7 U2SURP	4.90e-04	130	41	3	35545047
Pubmed	Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.	IPO5 MLLT3 IGBP1 AMER1 POLE3 HECTD1 U2SURP	5.79e-04	1247	41	7	27684187
Pubmed	Genome-wide association study of lung function decline in adults with and without asthma.	SLC24A3 TAF7	6.58e-04	32	41	2	22424883
Pubmed	Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.	PAXIP1 GNL2 ZHX3 TAF7	6.91e-04	341	41	4	32971831
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	GNL2 EHBP1 ZHX3 IGBP1 PCM1 U2SURP	7.44e-04	934	41	6	33916271
Pubmed	TRIM65 regulates microRNA activity by ubiquitination of TNRC6.	GNL2 IGBP1 HECTD1 U2SURP	8.80e-04	364	41	4	24778252
Pubmed	Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes.	PAXIP1 CHD6 IGBP1 PBRM1 PCM1	9.32e-04	645	41	5	25281560
Interaction	NEK4 interactions	NBPF10 NBPF8 MAPRE3 NBPF15 NBPF11 HECTD1 NBPF14 NBPF9 U2SURP AGTPBP1	1.87e-07	582	41	10	int:NEK4
Interaction	SPATS2 interactions	GNL2 BORCS6 HECTD1 TRIM44 PCM1	4.17e-06	119	41	5	int:SPATS2
Interaction	POLR1E interactions	PAXIP1 GNL2 CHD6 HIVEP1 PBRM1 HECTD1 AGTPBP1	6.07e-06	350	41	7	int:POLR1E
Interaction	CEP89 interactions	BORCS6 MLLT3 AMER1 CEP164 PCM1	1.17e-05	147	41	5	int:CEP89
Interaction	CKAP2L interactions	MAPRE3 HECTD1 PCM1	2.47e-05	28	41	3	int:CKAP2L
Interaction	H3C3 interactions	GNL2 IPO5 ZHX3 CHD6 HIVEP1 PBRM1 IPO4	5.64e-05	495	41	7	int:H3C3
Interaction	CENPE interactions	IPO5 PBRM1 HECTD1 PCM1	6.30e-05	106	41	4	int:CENPE
Interaction	HMMR interactions	GNL2 MAPRE3 HECTD1 PCM1	7.03e-05	109	41	4	int:HMMR
Interaction	TSPYL1 interactions	AMER1 HECTD1 TRIM44 PCM1	8.95e-05	116	41	4	int:TSPYL1
Interaction	CENPA interactions	GNL2 IPO5 CHD6 HIVEP1 PBRM1 IPO4	1.06e-04	377	41	6	int:CENPA
Interaction	COIL interactions	IPO5 MLLT3 CHD6 HIVEP1 PBRM1 IPO4 HECTD1	1.12e-04	552	41	7	int:COIL
Interaction	MCM10 interactions	GNL2 MAPRE3 HECTD1 PCM1	1.16e-04	124	41	4	int:MCM10
Cytoband	1q21.1	NBPF10 NBPF8 NBPF11 NBPF14 NBPF9	2.75e-09	62	41	5	1q21.1
Cytoband	Ensembl 112 genes in cytogenetic band chr1q21	NBPF10 NBPF19 NBPF15 NBPF11 NBPF14 NBPF9	1.55e-06	404	41	6	chr1q21
Cytoband	Ensembl 112 genes in cytogenetic band chr1p11	NBPF8 NBPF26	1.62e-04	21	41	2	chr1p11
Cytoband	20q12	ZHX3 CHD6	2.12e-04	24	41	2	20q12
Cytoband	Ensembl 112 genes in cytogenetic band chr20q12	ZHX3 CHD6	2.49e-04	26	41	2	chr20q12
Cytoband	3p21	PBRM1 SCN5A	4.04e-04	33	41	2	3p21
Cytoband	14q12	IPO4 HECTD1	1.12e-03	55	41	2	14q12
Cytoband	Ensembl 112 genes in cytogenetic band chr14q12	IPO4 HECTD1	4.01e-03	105	41	2	chr14q12
GeneFamily	Neuroblastoma breakpoint family	NBPF10 NBPF8 NBPF19 NBPF26 NBPF15 NBPF11 NBPF14 NBPF9	2.67e-18	23	26	8	662
GeneFamily	Armadillo repeat containing\|Importins	IPO5 IPO4	3.00e-04	18	26	2	596
Coexpression	GSE27786_CD8_TCELL_VS_MONO_MAC_UP	IPO5 CHD6 IGBP1 IPO4 TRIM44	1.44e-05	199	41	5	M4848
ToppCell	COPD-Myeloid-cMonocyte\|COPD / Disease state, Lineage and Cell class	NBPF10 NBPF19 NBPF26 NBPF14 AGTPBP1	8.22e-07	189	41	5	d29f3a0bd23e6eb46389e6eb7ef21851c7b57545
ToppCell	3'-Child09-12-SmallIntestine-Epithelial-Tuft-related-BEST4+_epithelial\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NBPF10 NBPF19 NBPF26 NBPF9	2.24e-05	180	41	4	b234668bf181522807470e396792e1b54890b719
ToppCell	COVID-19_Convalescent\|World / Disease condition and Cell class	NBPF19 NBPF26 NBPF15 NBPF14	2.28e-05	181	41	4	a62115a8da486fc61225901c72b1ec70bcaf4c36
ToppCell	COPD-Myeloid-cMonocyte\|World / Disease state, Lineage and Cell class	NBPF19 NBPF26 NBPF14 AGTPBP1	2.44e-05	184	41	4	ceec41ed5636032aaf7716d1203816ea58bd39bd
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)-Exc_L4_RORB_CACNG5\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NBPF10 NBPF19 SLC24A3 NBPF14	2.44e-05	184	41	4	658f2e522055e88c92bc482a845c40f8f5f1a8e3
ToppCell	COPD-Myeloid-cMonocyte\|Myeloid / Disease state, Lineage and Cell class	NBPF19 NBPF26 NBPF14 AGTPBP1	2.71e-05	189	41	4	6294691231c7d38707323cf31578a107d3b2c622
ToppCell	COPD-Myeloid-ncMonocyte\|World / Disease state, Lineage and Cell class	NBPF19 NBPF26 NBPF14 AGTPBP1	2.76e-05	190	41	4	aece860b5609ad5a8fc920d685f0d0ec71bf9018
ToppCell	COPD-Myeloid-ncMonocyte\|Myeloid / Disease state, Lineage and Cell class	NBPF19 NBPF26 NBPF14 AGTPBP1	2.76e-05	190	41	4	ed978cd5d9da87b49878a330e362762c487f849f
ToppCell	human_hepatoblastoma-Tumor_cells\|World / Sample and Cell Type and Tumor Cluster (all cells)	EHBP1 CHD6 HIVEP1 PCM1	2.88e-05	192	41	4	916fbec1c7ab7969bda711886ac88e877e30c280
ToppCell	human_hepatoblastoma\|World / Sample and Cell Type and Tumor Cluster (all cells)	EHBP1 CHD6 HIVEP1 PCM1	2.94e-05	193	41	4	e6a688bc834f845ff64dae1be64f073eec5091a1
ToppCell	COPD-Myeloid-ncMonocyte\|COPD / Disease state, Lineage and Cell class	NBPF19 NBPF26 NBPF14 AGTPBP1	2.94e-05	193	41	4	936ca95995599356b794fba32bfd82d8de339365
ToppCell	Control-Myeloid-ncMonocyte\|Control / Disease state, Lineage and Cell class	NBPF19 NBPF26 NBPF14 AGTPBP1	3.06e-05	195	41	4	fcb05948e7480dc53f06f3fc9b9c3fc129874edd
ToppCell	Control-Myeloid-ncMonocyte\|World / Disease state, Lineage and Cell class	NBPF19 NBPF26 NBPF14 AGTPBP1	3.06e-05	195	41	4	b4444b67a709e82b8e2ee510924c3152cb88b051
ToppCell	Neuronal-Excitatory-eC(RORB)-eC_1-CARM1P1\|Neuronal / cells hierarchy compared to all cells using T-Statistic	NBPF10 NBPF19 NBPF26 NBPF14	3.37e-05	200	41	4	f75d95376a340d467c4392b872b2a2dbdd184556
ToppCell	Neuronal-Excitatory-eC(RORB)-eC_1-CARM1P1--L3-4\|Neuronal / cells hierarchy compared to all cells using T-Statistic	NBPF10 NBPF19 NBPF26 NBPF14	3.37e-05	200	41	4	47791c93d03ee17c1ce17e27f075be4fc6f2590e
ToppCell	Neuronal-Excitatory-eC(RORB)-eC_1-CARM1P1-\|Neuronal / cells hierarchy compared to all cells using T-Statistic	NBPF10 NBPF19 NBPF26 NBPF14	3.37e-05	200	41	4	fae26560ba3b0b638b6bcf92f05330824b31d21b
Drug	Pesticides	NBPF10 NBPF8 NBPF15 NBPF11 NBPF14 NBPF9	2.02e-07	150	39	6	ctd:D010575
Disease	diastolic blood pressure, systolic blood pressure	GNL2 SLC24A3 CHD6 CEP164 PCM1 SCN5A	1.24e-04	670	35	6	EFO_0006335, EFO_0006336
Disease	creatine measurement	SLC24A3 TRIM44	8.40e-04	36	35	2	EFO_0010472
Disease	nicotine dependence symptom count, depressive symptom measurement	GNL2 SLC24A3	3.59e-03	75	35	2	EFO_0007006, EFO_0009262
Disease	insulin measurement	SLC24A3 MAPRE3 CHD6	3.87e-03	267	35	3	EFO_0004467

Protein segments in the cluster

Peptide	Gene	Start	Entry
EEESDEVEDNDNDSE	MLLT3	416	P42568
LQAQQEDSDEEDEEE	AMER1	921	Q5JTC6
QENEDRNSELDQDEE	LINC00471	61	Q8N535
DDNDDIDVEAENETE	AGTPBP1	371	Q9UPW5
DDEDDAEDENNIDNR	GON7	71	Q9BXV9
EEEEEVENEEQDSQN	PAXIP1	196	Q6ZW49
EADDEDDDEDGQDNQ	PBRM1	156	Q86U86
EEEEQEQQRDDAEES	GNL2	566	Q13823
DEEEEEEQDASSNDN	PCM1	916	Q15154
AAQQQEEQEEKEEED	IGBP1	296	P78318
QENSEETDENEAEEE	KIF21B	576	O75037
DNDEDEERLEEEEQN	POLE3	126	Q9NRF9
DEQVEESLQDEDDND	IPO5	821	O00410
IDDDDDDNCNNDEDE	ERMN	186	Q8TAM6
TENENEDNENDEEEE	SLC24A3	411	Q9HC58
EEDDENEDDNQEDQE	HECTD1	1686	Q9ULT8
DVEQQEEEDNDEEAA	BORCS6	136	Q96GS4
QNHSDEEEEEEENEE	CHD6	1861	Q8TD26
EDNEDDDENRVNQEE	EHBP1	191	Q8NDI1
EDDEIEEHQQEDQDE	MAPRE3	266	Q9UPY8
QDTDEEEEEEDDDQA	IPO4	811	Q8TEX9
EDEDETQHQDEEDIN	TAF7	231	Q15545
EQESEAEEDNQEEGE	TRIM44	136	Q96DX7
DNEEEIESADQEEEA	PLCB4	496	Q15147
ENDNDDDEDVQVEVA	NBPF8	401	Q3BBV2
ENDNDDDEDVQIEVA	NBPF9	436	P0DPF3
ENDNDDDEDVQVEVA	NBPF10	436	Q6P3W6
ENDNDDDEDVQVEVA	NBPF11	436	Q86T75
ENDNDDDEDVQVEVA	NBPF14	96	Q5TI25
NDNDDDEDVQVEVAE	NBPF15	166	Q8N660
NDNDDDEDVQVEVAE	NBPF19	166	A0A087WUL8
ENDNDDDEDVQVEVA	NBPF26	96	B4DH59
VAESDTDDQEEDEEN	SCN5A	1051	Q14524
QQQKQQEEEEEEEEE	SHROOM4	1126	Q9ULL8
EESEEEENQNQEEES	U2SURP	786	O15042
EENQNQEEESEDEED	U2SURP	791	O15042
EETNEEDEEESDNQS	CEP164	216	Q9UPV0
TQDEQEEENGNEKEE	FAM170A	276	A1A519
QEEDSQEEEEEDEEA	TMEM51	111	Q9NW97
QQQQEEEEEEEDSRD	PIEZO1	746	Q92508
EENASQEEEEAAEDE	ZHX3	676	Q9H4I2
DDNENEDDDEDSQAE	HIVEP1	2186	P15822