Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionprotein serine kinase activity

RIPK1 CDK15 OBSCN DAPK1 RIPK4 MAP3K6 STK11 MAP4K5 BUB1B RPS6KA6 ULK1 MAP3K21 STK24

8.10e-0636316113GO:0106310
GeneOntologyMolecularFunctionphosphotransferase activity, alcohol group as acceptor

RIPK1 GNE CDK15 FN3KRP OBSCN PKDCC DAPK1 RIPK4 MAP3K6 PTK2 STK11 PIK3CD MAP4K5 BUB1B RPS6KA6 ULK1 MAP3K21 STK24

1.74e-0570916118GO:0016773
GeneOntologyMolecularFunctionkinase activity

RIPK1 GNE CDK15 FN3KRP OBSCN PKDCC DAPK1 RIPK4 MAP3K6 PTK2 STK11 PIK3CD MAP4K5 BUB1B RPS6KA6 ULK1 MAP3K21 STK24

4.63e-0576416118GO:0016301
GeneOntologyMolecularFunctionprotein serine/threonine kinase activity

RIPK1 CDK15 OBSCN DAPK1 RIPK4 MAP3K6 STK11 MAP4K5 BUB1B RPS6KA6 ULK1 MAP3K21 STK24

6.91e-0544616113GO:0004674
GeneOntologyMolecularFunctionprotein kinase activity

RIPK1 CDK15 OBSCN PKDCC DAPK1 RIPK4 MAP3K6 PTK2 STK11 MAP4K5 BUB1B RPS6KA6 ULK1 MAP3K21 STK24

1.07e-0460016115GO:0004672
GeneOntologyMolecularFunctionATP-dependent activity

DHX16 MYO1G DYNC2H1 ATP13A1 SMC1A UBA2 RNF213 DHX33 KIF20B DHX8 DNAH1 DDX50 TOR1B ABCC2 DNAH9

1.38e-0461416115GO:0140657
GeneOntologyMolecularFunctiondihydrofolic acid binding

DHFR DHFR2

1.93e-0431612GO:0051871
GeneOntologyMolecularFunctiondihydrofolate reductase activity

DHFR DHFR2

1.93e-0431612GO:0004146
GeneOntologyMolecularFunctiontransferase activity, transferring phosphorus-containing groups

RIPK1 GNE CDK15 FN3KRP OBSCN PKDCC DAPK1 RIPK4 MAP3K6 PTK2 STK11 PAPOLA PIK3CD MAP4K5 BUB1B RPS6KA6 ULK1 MAP3K21 STK24

2.06e-0493816119GO:0016772
GeneOntologyMolecularFunctionATP hydrolysis activity

DHX16 DYNC2H1 ATP13A1 SMC1A RNF213 DHX33 KIF20B DHX8 DDX50 TOR1B ABCC2 DNAH9

2.49e-0444116112GO:0016887
GeneOntologyMolecularFunctionminus-end-directed microtubule motor activity

DYNC2H1 DNAH1 DNAH9

3.84e-04181613GO:0008569
GeneOntologyMolecularFunctionmodified amino acid binding

FTCDNL1 ASAP1 GSTM3 FASN DHFR DHFR2

4.68e-041221616GO:0072341
GeneOntologyMolecularFunctionfolic acid binding

FTCDNL1 DHFR DHFR2

5.30e-04201613GO:0005542
GeneOntologyMolecularFunctionNADPH binding

HMGCR DHFR DHFR2

1.17e-03261613GO:0070402
GeneOntologyBiologicalProcessestablishment of cell polarity

DOCK2 CLASP2 FRMD4B KIF20B PTK2 STK11 FRMD4A KANK1 ZW10

1.07e-051771619GO:0030010
DomainKinase-like_dom

RIPK1 CDK15 FN3KRP OBSCN PKDCC DAPK1 RIPK4 MAP3K6 PTK2 STK11 PTPN13 PIK3CD MAP4K5 BUB1B RPS6KA6 ULK1 MAP3K21 STK24

1.27e-0654216318IPR011009
DomainLRRC37AB_C

LRRC37A3 LRRC37A2 LRRC37A

2.59e-0641633IPR029423
DomainLRRC37AB_C

LRRC37A3 LRRC37A2 LRRC37A

2.59e-0641633PF14914
DomainLRRC37_N

LRRC37A3 LRRC37A2 LRRC37A

2.59e-0641633IPR032754
DomainLRRC37

LRRC37A3 LRRC37A2 LRRC37A

2.59e-0641633PF15779
DomainLRRC37A/B-like

LRRC37A3 LRRC37A2 LRRC37A

2.59e-0641633IPR015753
DomainANK

DAPK1 RIPK4 ASAP1 ANKRD46 ANKRD44 KANK1 TRANK1 ASB6 ASB11 PPP1R16B ANKRD52

1.32e-0525116311SM00248
DomainANK_REPEAT

DAPK1 RIPK4 ASAP1 ANKRD46 ANKRD44 KANK1 TRANK1 ASB6 ASB11 PPP1R16B ANKRD52

1.42e-0525316311PS50088
DomainANK_REP_REGION

DAPK1 RIPK4 ASAP1 ANKRD46 ANKRD44 KANK1 TRANK1 ASB6 ASB11 PPP1R16B ANKRD52

1.47e-0525416311PS50297
DomainSer/Thr_kinase_AS

RIPK1 CDK15 OBSCN DAPK1 RIPK4 MAP3K6 STK11 MAP4K5 BUB1B RPS6KA6 ULK1 MAP3K21 STK24

1.56e-0535716313IPR008271
DomainPROTEIN_KINASE_ST

RIPK1 CDK15 OBSCN DAPK1 RIPK4 MAP3K6 STK11 MAP4K5 BUB1B RPS6KA6 ULK1 MAP3K21 STK24

1.81e-0536216313PS00108
DomainAnkyrin_rpt

DAPK1 RIPK4 ASAP1 ANKRD46 ANKRD44 KANK1 TRANK1 ASB6 ASB11 PPP1R16B ANKRD52

1.96e-0526216311IPR002110
DomainProt_kinase_dom

RIPK1 CDK15 OBSCN PKDCC DAPK1 RIPK4 MAP3K6 PTK2 STK11 MAP4K5 BUB1B RPS6KA6 ULK1 MAP3K21 STK24

2.59e-0548916315IPR000719
DomainPROTEIN_KINASE_DOM

RIPK1 CDK15 OBSCN PKDCC DAPK1 RIPK4 MAP3K6 PTK2 STK11 MAP4K5 BUB1B RPS6KA6 ULK1 MAP3K21 STK24

2.85e-0549316315PS50011
DomainPkinase

RIPK1 CDK15 OBSCN PKDCC DAPK1 RIPK4 MAP3K6 STK11 MAP4K5 BUB1B RPS6KA6 ULK1 STK24

3.09e-0538116313PF00069
DomainAnk

DAPK1 RIPK4 ASAP1 ANKRD46 ANKRD44 KANK1 ASB6 ASB11 PPP1R16B ANKRD52

3.26e-0522816310PF00023
DomainPROTEIN_KINASE_ATP

CDK15 OBSCN PKDCC DAPK1 RIPK4 MAP3K6 PTK2 STK11 MAP4K5 BUB1B RPS6KA6 ULK1 MAP3K21 STK24

5.18e-0545916314PS00107
Domain-

DAPK1 ASAP1 ANKRD46 ANKRD44 KANK1 TRANK1 ASB6 ASB11 PPP1R16B ANKRD52

6.63e-05248163101.25.40.20
DomainDHFR_1

DHFR DHFR2

7.57e-0521632PF00186
DomainDHFR_1

DHFR DHFR2

7.57e-0521632PS00075
DomainDHFR_dom

DHFR DHFR2

7.57e-0521632IPR001796
DomainDHFR_2

DHFR DHFR2

7.57e-0521632PS51330
Domain-

DHFR DHFR2

7.57e-05216323.40.430.10
DomainDHFR-like_dom

DHFR DHFR2

7.57e-0521632IPR024072
DomainDHFR

DHFR DHFR2

7.57e-0521632IPR012259
DomainAnkyrin_rpt-contain_dom

DAPK1 ASAP1 ANKRD46 ANKRD44 KANK1 TRANK1 ASB6 ASB11 PPP1R16B ANKRD52

8.08e-0525416310IPR020683
DomainAnk_2

DAPK1 ASAP1 ANKRD46 ANKRD44 KANK1 ASB6 ASB11 PPP1R16B ANKRD52

1.16e-042151639PF12796
DomainARM-type_fold

DOCK2 USP9X RTTN PSMD2 NBEA CLASP2 PPP6R1 PPP4R4 PIK3CD TERB1 WDFY3

1.98e-0433916311IPR016024
DomainDynein_heavy_chain_D4_dom

DYNC2H1 DNAH1 DNAH9

2.21e-04141633IPR024317
DomainDynein_HC_stalk

DYNC2H1 DNAH1 DNAH9

2.21e-04141633IPR024743
DomainDynein_heavy_dom-2

DYNC2H1 DNAH1 DNAH9

2.21e-04141633IPR013602
DomainDHC_N2

DYNC2H1 DNAH1 DNAH9

2.21e-04141633PF08393
DomainATPase_dyneun-rel_AAA

DYNC2H1 DNAH1 DNAH9

2.21e-04141633IPR011704
DomainMT

DYNC2H1 DNAH1 DNAH9

2.21e-04141633PF12777
DomainAAA_8

DYNC2H1 DNAH1 DNAH9

2.21e-04141633PF12780
DomainAAA_5

DYNC2H1 DNAH1 DNAH9

2.21e-04141633PF07728
DomainVps51

EXOC8 COG1

2.26e-0431632IPR014812
DomainDHC_fam

DYNC2H1 DNAH1 DNAH9

2.75e-04151633IPR026983
DomainCAP

CLEC18A CLEC18B CLEC18C

2.75e-04151633PF00188
DomainSCP

CLEC18A CLEC18B CLEC18C

2.75e-04151633SM00198
DomainAllrgn_V5/Tpx1

CLEC18A CLEC18B CLEC18C

2.75e-04151633IPR001283
DomainDynein_heavy

DYNC2H1 DNAH1 DNAH9

2.75e-04151633PF03028
Domain-

CLEC18A CLEC18B CLEC18C

2.75e-041516333.40.33.10
DomainDynein_heavy_dom

DYNC2H1 DNAH1 DNAH9

2.75e-04151633IPR004273
DomainCAP_domain

CLEC18A CLEC18B CLEC18C

2.75e-04151633IPR014044
DomainS_TKc

RIPK1 CDK15 OBSCN DAPK1 MAP3K6 STK11 MAP4K5 RPS6KA6 ULK1 MAP3K21 STK24

3.23e-0435916311SM00220
DomainDUF1605

DHX16 DHX33 DHX8

4.06e-04171633IPR011709
DomainOB_NTP_bind

DHX16 DHX33 DHX8

4.06e-04171633PF07717
DomainP-loop_NTPase

DHX16 MYO1G DYNC2H1 SMC1A RNF213 DAPK1 ARL9 DHX33 KIF20B DHX8 DNAH1 EHD2 TRANK1 DDX50 TOR1B ABCC2 DNAH9 RHOT1

4.48e-0484816318IPR027417
DomainDUF3338

FRMD4B FRMD4A

4.49e-0441632PF11819
DomainDUF3338

FRMD4B FRMD4A

4.49e-0441632IPR021774
DomainHA2

DHX16 DHX33 DHX8

4.84e-04181633SM00847
DomainHA2

DHX16 DHX33 DHX8

4.84e-04181633PF04408
DomainHelicase-assoc_dom

DHX16 DHX33 DHX8

4.84e-04181633IPR007502
DomainProtein_kinase_ATP_BS

CDK15 OBSCN DAPK1 MAP3K6 PTK2 STK11 MAP4K5 RPS6KA6 ULK1 MAP3K21 STK24

5.09e-0437916311IPR017441
DomainARM-like

DOCK2 USP9X RTTN PSMD2 NBEA CLASP2 PPP4R4 TERB1 WDFY3

6.23e-042701639IPR011989
DomainFERM_M

FRMD4B PTK2 FRMD4A PTPN13

6.86e-04461634PF00373
DomainFerI

DYSF OTOF

7.44e-0451632SM01202
DomainFerB

DYSF OTOF

7.44e-0451632SM01201
DomainFerlin_B-domain

DYSF OTOF

7.44e-0451632IPR012561
DomainAnaphylatoxin_comp_syst

C4A C4B

7.44e-0451632IPR018081
DomainFerlin_C

DYSF OTOF

7.44e-0451632PF16165
DomainFerlin_C

DYSF OTOF

7.44e-0451632IPR032362
DomainFerIin_dom

DYSF OTOF

7.44e-0451632IPR012968
DomainAnaphylatoxn_comp_syst_dom

C4A C4B

7.44e-0451632IPR001840
DomainFerI

DYSF OTOF

7.44e-0451632PF08151
DomainFerB

DYSF OTOF

7.44e-0451632PF08150
DomainSterol-sensing

HMGCR PTCH2

7.44e-0451632PF12349
DomainDUF4704

NBEA WDFY3

7.44e-0451632IPR031570
DomainDUF4704

NBEA WDFY3

7.44e-0451632PF15787
DomainFERM_central

FRMD4B PTK2 FRMD4A PTPN13

8.73e-04491634IPR019748
DomainFERM_domain

FRMD4B PTK2 FRMD4A PTPN13

8.73e-04491634IPR000299
DomainFERM/acyl-CoA-bd_prot_3-hlx

FRMD4B PTK2 FRMD4A PTPN13

9.42e-04501634IPR014352
DomainFERM_1

FRMD4B PTK2 FRMD4A PTPN13

9.42e-04501634PS00660
DomainFERM_2

FRMD4B PTK2 FRMD4A PTPN13

9.42e-04501634PS00661
DomainFERM_3

FRMD4B PTK2 FRMD4A PTPN13

9.42e-04501634PS50057
DomainBand_41_domain

FRMD4B PTK2 FRMD4A PTPN13

9.42e-04501634IPR019749
DomainB41

FRMD4B PTK2 FRMD4A PTPN13

9.42e-04501634SM00295
DomainPH_BEACH

NBEA WDFY3

1.11e-0361632PF14844
DomainPH_dom-like

OBSCN NBEA SSRP1 FRMD4B PTK2 ASAP1 EXOC8 FRMD4A PTPN13 PLCB4 WDFY3

1.32e-0342616311IPR011993
DomainFERM_C

FRMD4B FRMD4A PTPN13

1.46e-03261633PF09380
DomainANATO

C4A C4B

1.54e-0371632SM00104
DomainANAPHYLATOXIN_2

C4A C4B

1.54e-0371632PS01178
DomainANAPHYLATOXIN_1

C4A C4B

1.54e-0371632PS01177
DomainANATO

C4A C4B

1.54e-0371632PF01821
DomainAnaphylatoxin/fibulin

C4A C4B

1.54e-0371632IPR000020
DomainFERM_PH-like_C

FRMD4B FRMD4A PTPN13

1.64e-03271633IPR018980
DomainFERM_C

FRMD4B FRMD4A PTPN13

1.64e-03271633SM01196
DomainDHC_N1

DYNC2H1 DNAH9

2.05e-0381632PF08385
DomainMacrogloblnA2_thiol-ester-bond

C4A C4B

2.05e-0381632IPR019565
DomainPH-BEACH_dom

NBEA WDFY3

2.05e-0381632IPR023362
Domain-

NBEA WDFY3

2.05e-03816322.30.29.40
DomainThiol-ester_cl

C4A C4B

2.05e-0381632PF10569
DomainPH_BEACH

NBEA WDFY3

2.05e-0381632PS51783
DomainMacrogloblnA2_CS

C4A C4B

2.05e-0381632IPR019742
DomainDynein_heavy_dom-1

DYNC2H1 DNAH9

2.05e-0381632IPR013594
Domain-

DHX16 DYNC2H1 SMC1A RNF213 ARL9 DHX33 DHX8 DNAH1 EHD2 TRANK1 DDX50 TOR1B ABCC2 DNAH9 RHOT1

2.29e-03746163153.40.50.300
DomainBEACH

NBEA WDFY3

2.62e-0391632PS50197
DomainBeach

NBEA WDFY3

2.62e-0391632PF02138
Domain-

NBEA WDFY3

2.62e-03916321.10.1540.10
Pubmed

Cytoplasmic Metadherin (MTDH) provides survival advantage under conditions of stress by acting as RNA-binding protein.

DOCK2 RIPK1 SYNE1 OBSCN RNF213 SEZ6L2 LRIG3 FASN RNF123 GLG1

1.07e-072141691022199357
Pubmed

Human CLEC18 Gene Cluster Contains C-type Lectins with Differential Glycan-binding Specificity.

CLEC18A CLEC18B CLEC18C

1.13e-073169326170455
Pubmed

The C-type lectin-like domain superfamily.

CLEC18A CLEC18B CLEC18C

1.13e-073169316336259
Pubmed

Endosomal TLR3 co-receptor CLEC18A enhances host immune response to viral infection.

CLEC18A CLEC18B CLEC18C

1.13e-073169333603190
Pubmed

HAPSTR1 localizes HUWE1 to the nucleus to limit stress signaling pathways.

USP9X SMC1A PSMD2 HMGCR COPS3 PPP6R1 SSRP1 DDB1 CUL5 CERS5 FASN EFHD1 DHFR ANKRD52 RHOT1

1.47e-075711691537167062
Pubmed

Rab40c regulates focal adhesions and PP6 activity by controlling ANKRD28 ubiquitylation.

PPP6R1 CUL5 ANKRD44 ANKRD52

2.58e-0712169435512830
Pubmed

The mannose receptor mediates uptake of soluble but not of cell-associated antigen for cross-presentation.

CLEC18A CLEC18B CLEC18C

4.49e-074169316709836
Pubmed

Exome sequencing in seven families and gene-based association studies indicate genetic heterogeneity and suggest possible candidates for fibromuscular dysplasia.

DYNC2H1 OBSCN RNF213

4.49e-074169326147384
Pubmed

Primate segmental duplication creates novel promoters for the LRRC37 gene family within the 17q21.31 inversion polymorphism region.

LRRC37A3 LRRC37A2 LRRC37A

4.49e-074169322419166
Pubmed

Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.

DHX16 PPP6R1 MAP3K6 PTK2 EXOC8 CUL5 BUB1B C4A C4B ULK1 CWF19L1 QSOX2 ALG1 RHOT1 MOCOS

7.54e-076501691538777146
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

TPRA1 LMF1 VPS13C SPTB OBSCN RNF213 CLASP2 SMOC2 PTK2 PPP4R4 DNAH1 CUL5 ANKRD44 LRPPRC PTPN13 PTPRG GPR137C EFHD1 GCC2 NAXD PLCB4 MOCOS PCNT

9.96e-0714891692328611215
Pubmed

FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.

USP9X OBSCN NBEA CLASP2 COPS3 DYSF DDB1 KRBA1 TRANK1 LGI2 C4A C4B PLCB4

1.08e-064971691336774506
Pubmed

Defining the membrane proteome of NK cells.

DOCK2 MYO1G ATP13A1 USP9X RNF213 PSMD2 CLASP2 ANO10 LTB4R2 ACOX3 EXOC8 LRPPRC FASN DDX50 GLG1 GCC2 ZW10 ALG1 RHOT1 PCNT

1.14e-0611681692019946888
Pubmed

A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.

RIPK1 USP9X MCC PSMD2 PPP6R1 LRPPRC PAPOLA GLG1

1.38e-06162169814743216
Pubmed

SERBP1 Promotes Stress Granule Clearance by Regulating 26S Proteasome Activity and G3BP1 Ubiquitination and Protects Male Germ Cells from Thermostimuli Damage.

CDK15 OGFR USP9X FN3KRP UBA2 PSMD2 COPS3 CRMP1 EXOC8 GSTM3 LRPPRC FASN PAPOLA COG1 FH QSOX2 PCMT1

1.50e-068781691737223481
Pubmed

An integrated genetic map of the pearl locus of mouse chromosome 13.

PDE4C HMGCR DHFR DHFR2

1.97e-061916948828042
Pubmed

The proximal proteome of 17 SARS-CoV-2 proteins links to disrupted antiviral signaling and host translation.

DHX16 RIPK1 ATP13A1 VPS13C ANO10 SSRP1 GSTM3 PTPN13 COG1 EFHD1 GLG1 MAP4K5 DHFR TTC13 MAP3K21 CWF19L1 QSOX2 PCMT1

2.24e-0610071691834597346
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

DHX16 DIS3L2 GNE SMC1A PSMD2 COPS3 DHX33 SSRP1 DDB1 KIF20B PTK2 ASAP1 LRPPRC FASN DDX50 BAZ2A MAP4K5 WDFY3 CDC27 ANKRD52 PCMT1

2.85e-0613531692129467282
Pubmed

Large-scale mapping of human protein-protein interactions by mass spectrometry.

CDK15 USP9X SMC1A NELFB MCC UBA2 PSMD2 CLASP2 COPS3 PTK2 CUL5 GSTM3 LRPPRC RNF123 EFHD1 ULK1 ZW10 MAP3K21 STK24 PCMT1

4.75e-0612841692017353931
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

ATP13A1 USP9X SYNE1 SMC1A SPTB PLA2G3 PSMD2 NBEA RIPK4 FRMD4B PTK2 CRMP1 WDR19 RNF123 PTPN13 OTOF COG1 PPP1R16B WDFY3 PCNT

4.81e-0612851692035914814
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

DHX16 SYNE1 PPP6R1 ASAP1 LRIG3 KANK1 LGI2 BAZ2A GCC2 ULK1 PCNT

5.45e-064071691112693553
Pubmed

Protein interaction screening for the ankyrin repeats and suppressor of cytokine signaling (SOCS) box (ASB) family identify Asb11 as a novel endoplasmic reticulum resident ubiquitin ligase.

USP9X PSMD2 CLASP2 DDB1 CUL5 LRPPRC ASB6 ASB11

6.11e-06198169824337577
Pubmed

Protein phosphatase 6 regulatory subunits composed of ankyrin repeat domains.

PPP6R1 ANKRD44 ANKRD52

6.20e-068169318186651
Pubmed

A high-throughput approach for measuring temporal changes in the interactome.

GNE OGFR USP9X SMC1A NELFB UBA2 PSMD2 COPS3 SSRP1 DDB1 CRMP1 CUL5 GDA FASN RNF123 PAPOLA ASB6 BUB1B ZW10 FH STK24

8.68e-0614551692122863883
Pubmed

Protein phosphatase 6 regulates mitotic spindle formation by controlling the T-loop phosphorylation state of Aurora A bound to its activator TPX2.

PPP6R1 ANKRD44 ANKRD52

9.27e-069169321187329
Pubmed

Targeted ubiquitination and degradation of G-protein-coupled receptor kinase 5 by the DDB1-CUL4 ubiquitin ligase complex.

USP9X PSMD2 DDB1 LRPPRC KANK1 GLG1 CTDP1

1.20e-05156169722952844
Pubmed

Evolutionary dynamism of the primate LRRC37 gene family.

LRRC37A3 LRRC37A2 LRRC37A

1.32e-0510169323064749
Pubmed

Regulation of axonal morphogenesis by the mitochondrial protein Efhd1.

STK11 EFHD1 ULK1

1.32e-0510169332414840
Pubmed

An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.

LMF1 ATP13A1 VPS13C SLC43A1 MCC RNF213 CLASP2 HMGCR DDB1 FRMD4B DHX8 KANK1 ASB6 TTC13

1.53e-057331691434672954
Pubmed

The AAA-ATPase ATAD1 and its partners promote degradation of desmin intermediate filaments in muscle.

UBA2 PSMD2 CUL5 RNF123

1.74e-0532169436278411
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

USP9X SYNE1 SPTB DAPK1 PSMD2 NBEA CLASP2 COPS3 DDB1 ASAP1 CRMP1 CUL5 CERS5 GDA LRPPRC FASN C4A C4B FH RHOT1

2.28e-0514311692037142655
Pubmed

Copy number analysis of complement C4A, C4B and C4A silencing mutation by real-time quantitative polymerase chain reaction.

C4A C4B

2.35e-052169222737222
Pubmed

Deficiency of C4 from donor or recipient mouse fails to prevent renal allograft rejection.

C4A C4B

2.35e-052169216565498
Pubmed

Complete deficiencies of complement C4A and C4B including 2-bp insertion in codon 1213 are genetic risk factors of systemic lupus erythematosus in Thai populations.

C4A C4B

2.35e-052169215998580
Pubmed

High-throughput analysis of the C4 polymorphism by a combination of MLPA and isotype-specific ELISA's.

C4A C4B

2.35e-052169219062096
Pubmed

The role of PTPN13 in invasion and metastasis of lung squamous cell carcinoma.

PTK2 PTPN13

2.35e-052169223906871
Pubmed

Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice.

C4A C4B

2.35e-052169219933335
Pubmed

Focal adhesion kinase suppresses apoptosis by binding to the death domain of receptor-interacting protein.

RIPK1 PTK2

2.35e-052169215121855
Pubmed

Structural basis for the C4d.1/C4d.2 serologic allotypes of murine complement component C4.

C4A C4B

2.35e-05216922459207
Pubmed

Antigen-induced B cell apoptosis is independent of complement C4.

C4A C4B

2.35e-052169217645767
Pubmed

Anti-DNA autoreactivity in C4-deficient mice.

C4A C4B

2.35e-052169212207352
Pubmed

Complement C4A and C4B Gene Copy Number Study in Alzheimer's Disease Patients.

C4A C4B

2.35e-052169227758680
Pubmed

Genetically determined partial complement C4 deficiency states are not independent risk factors for SLE in UK and Spanish populations.

C4A C4B

2.35e-052169222387014
Pubmed

Complement C4 maintains peripheral B-cell tolerance in a myeloid cell dependent manner.

C4A C4B

2.35e-052169223749435
Pubmed

Copy number variations of complement component C4 are associated with Behçet's disease but not with ankylosing spondylitis associated with acute anterior uveitis.

C4A C4B

2.35e-052169223918728
Pubmed

Molecular genetics of androgen-dependent and -independent expression of mouse sex-limited protein.

C4A C4B

2.35e-05216923037333
Pubmed

Evidence of a role for C4 in modulating interstitial inflammation in experimental glomerulonephritis.

C4A C4B

2.35e-052169211726230
Pubmed

Quantitative variations in the expression of the mouse serum antigen Ss and its sex-limited allotype Slp.

C4A C4B

2.35e-05216924216347
Pubmed

Sequence determination of the thiolester site of the fourth component of human complement.

C4A C4B

2.35e-05216926950384
Pubmed

Visual demonstration of the organization of the human complement C4 and 21-hydroxylase genes by high-resolution fluorescence in situ hybridization.

C4A C4B

2.35e-05216928660986
Pubmed

Tissue-specific RNA processing for the complement C4 gene transcript in the H-2k mouse strain.

C4A C4B

2.35e-05216928428773
Pubmed

Complement C4 deficiency--a plausible risk factor for non-tuberculous mycobacteria (NTM) infection in apparently immunocompetent patients.

C4A C4B

2.35e-052169224638111
Pubmed

Transcriptional repression of C4 complement by hepatitis C virus proteins.

C4A C4B

2.35e-052169221345967
Pubmed

Restriction fragment analysis of H-2 recombinant mouse strains with crossovers between E alpha and C4 genes.

C4A C4B

2.35e-05216922572548
Pubmed

The complement component C4 of mammals.

C4A C4B

2.35e-05216922302180
Pubmed

Gene CNVs and protein levels of complement C4A and C4B as novel biomarkers for partial disease remissions in new-onset type 1 diabetes patients.

C4A C4B

2.35e-052169222151770
Pubmed

C4d-positive chronic rejection: a frequent entity with a poor outcome.

C4A C4B

2.35e-052169218091514
Pubmed

Comprehensive approach to study complement C4 in systemic lupus erythematosus: Gene polymorphisms, protein levels and functional activity.

C4A C4B

2.35e-052169229080553
Pubmed

Genes for murine fourth complement component (C4) and sex-limited protein (Slp) identified by hybridization to C4- and Slp-specific cDNA.

C4A C4B

2.35e-05216926589636
Pubmed

C4 Deficiency is a predisposing factor for Streptococcus pneumoniae-induced autoantibody production.

C4A C4B

2.35e-052169225339671
Pubmed

A study of association of the complement C4 mutations with systemic lupus erythematosus in the Malaysian population.

C4A C4B

2.35e-052169217728371
Pubmed

Structure and organization of the C4 genes.

C4A C4B

2.35e-05216926149580
Pubmed

Sequence heterogeneity of murine complementary DNA clones related to the C4 and C4-Slp isoforms of the fourth complement component.

C4A C4B

2.35e-05216926149581
Pubmed

The follicular dendritic cell restricted epitope, FDC-M2, is complement C4; localization of immune complexes in mouse tissues.

C4A C4B

2.35e-052169212115608
Pubmed

Biochemistry and biology of anaphylatoxins.

C4A C4B

2.35e-05216923542363
Pubmed

C4 from C4-high and C4-low mouse strains have identical sequences in the region corresponding to the isotype-specific segment of human C4.

C4A C4B

2.35e-05216922387317
Pubmed

LKB1 represses focal adhesion kinase (FAK) signaling via a FAK-LKB1 complex to regulate FAK site maturation and directional persistence.

PTK2 STK11

2.35e-052169223637231
Pubmed

Identification of the size and antigenic determinants of the human C4 gene by a polymerase chain-reaction-based amplification method.

C4A C4B

2.35e-052169216908004
Pubmed

Structural studies on the murine fourth component of complement (C4). IV. Demonstration that C4 and Slp are encoded by separate loci.

C4A C4B

2.35e-05216927365238
Pubmed

Interaction between the labile binding sites of the fourth (C4) and fifth (C5) human complement proteins and erythrocyte cell membranes.

C4A C4B

2.35e-05216927391573
Pubmed

Peritubular capillary C4d deposition in lupus nephritis different from antibody-mediated renal rejection.

C4A C4B

2.35e-052169217971360
Pubmed

The Autophagy-Initiating Kinase ULK1 Controls RIPK1-Mediated Cell Death.

RIPK1 ULK1

2.35e-052169232320653
Pubmed

Clinical features of patients with homozygous complement C4A or C4B deficiency.

C4A C4B

2.35e-052169229928053
Pubmed

Analysis of C4 and the C4 binding protein in the MRL/lpr mouse.

C4A C4B

2.35e-052169217971229
Pubmed

Genetic deficiency of C4 presenting with recurrent infections and a SLE-like disease. Genetic and immunologic studies.

C4A C4B

2.35e-05216926881182
Pubmed

Partial C4 deficiency in juvenile idiopathic arthritis patients.

C4A C4B

2.35e-052169217921792
Pubmed

Complement activation and complement receptors on follicular dendritic cells are critical for the function of a targeted adjuvant.

C4A C4B

2.35e-052169221880985
Pubmed

Amino acid sequence around the thiol and reactive acyl groups of human complement component C4.

C4A C4B

2.35e-05216926978711
Pubmed

Plasma Complement 3 and Complement 4 Are Promising Biomarkers for Distinguishing NMOSD From MOGAD and Are Associated With the Blood-Brain-Barrier Disruption in NMOSD.

C4A C4B

2.35e-052169235898513
Pubmed

Borrelia burgdorferi outer surface protein C (OspC) binds complement component C4b and confers bloodstream survival.

C4A C4B

2.35e-052169228873507
Pubmed

Studies on the murine Ss protein: demonstration that the Ss protein is functionally the fourth component of complement.

C4A C4B

2.35e-0521692276882
Pubmed

Amino acid sequence of a polymorphic segment from fragment C4d of human complement component C4.

C4A C4B

2.35e-05216926832377
Pubmed

Recombination of two homologous MHC class III genes of the mouse (C4 and Slp) that accounts for the loss of testosterone dependence of sex-limited protein expression.

C4A C4B

2.35e-05216923794341
Pubmed

Fine-tuned characterization of RCCX copy number variants and their relationship with extended MHC haplotypes.

C4A C4B

2.35e-052169222785613
Pubmed

Association between complement 4 copy number variation and systemic lupus erythematosus: a meta-analysis.

C4A C4B

2.35e-052169232691186
Pubmed

The androgen-dependent C4-Slp gene is driven by a constitutively competent promoter.

C4A C4B

2.35e-05216928390682
Pubmed

Structure and expression of murine fourth complement component (C4) and sex-limited protein (Slp).

C4A C4B

2.35e-05216923902619
Pubmed

Structural polymorphism of murine C4 and its linkage to H-2.

C4A C4B

2.35e-05216927373044
Pubmed

The chemical structure of the C4d fragment of the human complement component C4.

C4A C4B

2.35e-05216923696167
Pubmed

Restriction fragment length polymorphism of the murine C4 and Slp genes: two C4 groups.

C4A C4B

2.35e-05216921357031
Pubmed

Structural comparison of human C4A3 and C4B1 after proteolytic activation by C1s.

C4A C4B

2.35e-052169216098595
Pubmed

Increased frequency of C4B*Q0 alleles in patients with Henoch-Schönlein purpura.

C4A C4B

2.35e-052169215787745
Pubmed

Neuropil contraction in relation to Complement C4 gene copy numbers in independent cohorts of adolescent-onset and young adult-onset schizophrenia patients-a pilot study.

C4A C4B

2.35e-052169230026462
Pubmed

A molecular map of the human major histocompatibility complex class III region linking complement genes C4, C2 and factor B.

C4A C4B

2.35e-05216926559257
Pubmed

Complement C4 Is Reduced in iPSC-Derived Astrocytes of Autism Spectrum Disorder Subjects.

C4A C4B

2.35e-052169234299197
Pubmed

Assessment of complement C4 gene copy number using the paralog ratio test.

C4A C4B

2.35e-052169220506482
Pubmed

Polymerase chain reaction based C4AQ0 and C4BQ0 genotyping: association with systemic lupus erythematosus in southwest Han Chinese.

C4A C4B

2.35e-052169212480675
Pubmed

Biochemical and Functional Characterization of RNF213 (Mysterin) R4810K, a Susceptibility Mutation of Moyamoya Disease, in Angiogenesis In Vitro and In Vivo.

RNF213 RNF123

2.35e-052169226126547
Pubmed

Low C4, C4A and C4B gene copy numbers are stronger risk factors for juvenile-onset than for adult-onset systemic lupus erythematosus.

C4A C4B

2.35e-052169226800705
Pubmed

Murine complement C4 is not required for experimental autoimmune encephalomyelitis.

C4A C4B

2.35e-052169215390104
InteractionDNAJC7 interactions

DYNC2H1 VPS13C PSMD2 RIPK4 DDB1 KIF20B WDR19 FASN DHFR2 BUB1B MAP3K21 MOCOS RAD9A PCNT

1.11e-0542516514int:DNAJC7
InteractionHUWE1 interactions

PDE4A USP9X SMC1A SPTB PSMD2 HMGCR COPS3 RIPK4 PPP6R1 SSRP1 DDB1 CRMP1 CUL5 CERS5 FASN RNF123 PAPOLA EFHD1 DHFR DHFR2 ANKRD52 PCMT1 RHOT1 PCNT

1.26e-05111016524int:HUWE1
Cytoband6q24-q25

PLAGL1 PCMT1

1.34e-04516926q24-q25
GeneFamilyAnkyrin repeat domain containing

DAPK1 RIPK4 ASAP1 ANKRD46 ANKRD44 KANK1 TRANK1 ASB6 ASB11 PPP1R16B ANKRD52

3.45e-0724211311403
GeneFamilyProtein phosphatase 6 regulatory subunits

PPP6R1 ANKRD44 ANKRD52

4.69e-0661133699
GeneFamilyDEAH-box helicases

DHX16 DHX33 DHX8

1.25e-04161133500
GeneFamilyAnkyrin repeat domain containing|FERM domain containing

FRMD4B PTK2 FRMD4A PTPN13

2.67e-045011341293
GeneFamilyFerlin family

DYSF OTOF

5.71e-0461132828
GeneFamilyC3 and PZP like, alpha-2-macroglobulin domain containing

C4A C4B

1.35e-03911321234
GeneFamilyWD repeat domain containing|BEACH domain containing

NBEA WDFY3

1.35e-03911321230
GeneFamilyC-type lectin domain family

CLEC18A CLEC18B CLEC18C

3.16e-03471133494
ToppCellBrain_organoid-organoid_Paulsen_bioRxiv-1_mon-Proliferating-Cycling_Progenitors|1_mon / Sample Type, Dataset, Time_group, and Cell type.

USP9X DAPK1 DHX33 ASAP1 PTPN13 EFHD1 DHFR RIMOC1 STK24

7.33e-081991699358c4b3037f59378db8916a2fbe9ed4830cf1449
ToppCellControl-Epithelial_cells-AT2|Control / group, cell type (main and fine annotations)

SYNE1 FRMD4B PPP4R4 FASN KANK1 PTPN13 PTPRG ALOX15B

4.53e-071801698198b19e7910b4a8cc7e820c525ab357c7f99f578
ToppCellnucseq-Epithelial-Epithelial_Alveolar-AT2-AT2|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

SYNE1 FRMD4B PPP4R4 FASN KANK1 PTPN13 PTPRG ALOX15B

7.67e-071931698fd4d3c0d7caf8a2fff5b3d901fc28d19a8163cdf
ToppCellnucseq-Epithelial-Epithelial_Alveolar-AT2|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

SYNE1 FRMD4B PPP4R4 FASN KANK1 PTPN13 PTPRG ALOX15B

7.67e-071931698f3cc7cfdbc164a4ed42f87647111522b7d393bcb
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DYNC2H1 USP9X VPS13C NBEA HMGCR SEZ6L2 DDB1 TSHZ1

8.29e-0719516987796ea9247f4c63762f0de8490fed08b9717fa23
ToppCellfacs-Tongue-nan-3m-Epithelial|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

USP9X UBA2 CLASP2 RIPK4 EHD2 GLG1 MAP4K5 LYPLA1

9.30e-0719816982f03f8897dd7cce6d8296638e14e11ec16bcf624
ToppCellfacs-Tongue-nan-3m|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

USP9X UBA2 CLASP2 RIPK4 EHD2 GLG1 MAP4K5 LYPLA1

9.30e-071981698f2a4057f038ef7225a5b98a7ab068c30dff4eadd
ToppCell5'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.3.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SYNE1 HMGCR SEZ6L2 FASN KANK1 PTPN13 PTPRG ALOX15B

9.66e-0719916982dc33804f6691d7c9682e6c9b885e945fb97fc36
ToppCellfacs-Lung-18m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l25-31|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SERPINF1 SMOC2 DNAH1 LGI2 EFHD1 PTCH2 ANKRD52

7.48e-061871697fa8f221b4c2df61eadaa9c77e4cf45848b00330b
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

GNE DAPK1 SMOC2 CRMP1 KANK1 LGI2 WDFY3

8.02e-061891697904b8337e2cabac2f0bf5dad5598fc429581ed81
ToppCellrenal_medulla_nuclei|World / Celltypes from Cells and Nuclei per compartment and clinical group

SYNE1 DAPK1 PTK2 CRMP1 KANK1 PTPN13 WDFY3

8.02e-061891697830d9cd0dd706bce22eb2416f07b2c31c870a05a
ToppCellRV-08._Macrophage|World / Chamber and Cluster_Paper

DOCK2 RNF213 DAPK1 FRMD4B PIK3CD BUB1B PLTP

8.89e-061921697a1b5dc5beb97a23729b97b54fb4574d10d8fbfb3
ToppCellTCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-6|TCGA-Prostate / Sample_Type by Project: Shred V9

FOXN2 USP9X SMC1A LRPPRC BAZ2A GCC2 WDFY3

9.19e-061931697abd71b2cf667ef2b1c4d88acd0c1dd19a12ff659
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_2|Adult / Lineage, Cell type, age group and donor

FRMD4B PPP4R4 FASN KANK1 PTPN13 PTPRG ALOX15B

9.19e-061931697738f4f0a9ddde2432b429ab46838e353b1790589
ToppCellLPS-IL1RA-Endothelial-Endothelial-Gen_Cap|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MCC DYSF PTK2 SHROOM4 PTPRG PPP1R16B PLCB4

9.51e-0619416970b9cd96fa0b616da7cc90e92ff71157e9bba518f
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DYNC2H1 USP9X VPS13C NBEA HMGCR SEZ6L2 TSHZ1

9.83e-0619516973e519cffa6144a62b06124642a14c9ff39b76554
ToppCellfacs-Tongue-nan-3m-Epithelial-nan|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

USP9X UBA2 CLASP2 DDB1 EHD2 GLG1 LYPLA1

1.12e-0519916978d50e1ee58710d896c0204937331d9f4dcd38de0
ToppCellE16.5-samps-Myeloid-Fetal_macrophage-Proliferative_Myeloid|E16.5-samps / Age Group, Lineage, Cell class and subclass

DOCK2 MYO1G GAL GDA GVINP1 PIK3CD

2.53e-051521696e427758a6e39052616a0d8ecec0c1299e81d1d3c
ToppCellE16.5-samps-Myeloid|E16.5-samps / Age Group, Lineage, Cell class and subclass

DOCK2 MYO1G GAL GDA GVINP1 PIK3CD

2.93e-051561696c7c73cef5700b0ae75280e62c94728434c712537
ToppCellTCGA-Skin-Metastatic-Melanoma-Skin_Cutaneous_Melanoma-3|TCGA-Skin / Sample_Type by Project: Shred V9

MCC CLASP2 ASAP1 ANKRD46 ASB11 RAPGEF3

3.26e-051591696fb222c42f66901852b01cec073ec0732245ee973
ToppCellE18.5-samps-Myeloid-Macrophage-macrophage_-_intermediate_-_unactivated|E18.5-samps / Age Group, Lineage, Cell class and subclass

DOCK2 MYO1G GAL GDA GVINP1 PIK3CD

3.62e-05162169660d3fe1f5cec4285b8774ff078ebcc6bfaec26ed
ToppCell356C-Myeloid-Macrophage-FABP4+_Macrophage|Macrophage / Donor, Lineage, Cell class and subclass (all cells)

SYNE1 PLA2G3 SEZ6L2 MAP3K6 PTPN13 PTPRG

3.62e-0516216962259e9536147e9cdee772e3a30ba7d104573262c
ToppCellE18.5-samps-Myeloid|E18.5-samps / Age Group, Lineage, Cell class and subclass

DOCK2 MYO1G GAL GDA GVINP1 PIK3CD

3.62e-05162169618e4a807e25f754a69e9eaaddfde40f8de9b8512
ToppCellE18.5-samps-Myeloid-Macrophage|E18.5-samps / Age Group, Lineage, Cell class and subclass

DOCK2 MYO1G GAL GDA GVINP1 PIK3CD

3.62e-0516216960970e4eda60e3f015335e2726e6d565fb2f43372
ToppCell356C-Myeloid-Macrophage-FABP4+_Macrophage|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

SYNE1 PLA2G3 SEZ6L2 MAP3K6 PTPN13 PTPRG

4.15e-05166169689e2b8453180983533faccb4275867861876d7ee
ToppCellPND01-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_G2M|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MYO1G RTTN KIF20B GAL GDA PIK3CD

4.44e-05168169652fd65024af8683db11d931f7563cbe8eb815d1c
ToppCell343B-Myeloid-Dendritic-pDC|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

SERPINF1 MAP3K6 GPR146 PTPRG PPP1R16B PTCH2

4.59e-051691696632aa3ab39ec87bafcefec6cddf71129a054d3b0
ToppCellLV-17._Lymphocyte|World / Chamber and Cluster_Paper

DOCK2 MYO1G CDK15 ANKRD44 PIK3CD PPP1R16B

5.22e-051731696212f013ff761cbab24a537071739867c08c402a4
ToppCellnormal_Lymph_Node-B_lymphocytes-GrB-secreting_B_cells|B_lymphocytes / Location, Cell class and cell subclass

LRRC37A3 SERPINF1 MCC FRMD4B PLCB4 ULK1

5.75e-051761696d6e660df92a3d7dd5732171ee623763faf108476
ToppCellfacs-Diaphragm-Limb_Muscle-18m-Endothelial-nan|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CPT1B SEZ6L2 ASB11 RAPGEF3 PPP1R16B PLTP

5.75e-051761696a3f27b5d7edf2d396c085efbe35305cfa0afa565
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SYNE1 DAPK1 SMOC2 CRMP1 LGI2 WDFY3

5.75e-051761696327a3e81b724252e36d786de92a3ffd721ea6d7b
ToppCellIIH-CD8-antiviral_CD4|IIH / Condition, Cell_class and T cell subcluster

LMF1 RTTN ACOX3 KRBA1 ULK1 ALG1

5.93e-051771696fe73608c40701eca88b260aeb5c0640d7bee72ba
ToppCellChildren_(3_yrs)-Epithelial-basal_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

SERPINF1 MCC SMOC2 PTK2 LRIG3 PTPN13

6.12e-051781696fba2e38c05cbf031e0c6d47b1602575fea734a57
ToppCelldroplet-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l25|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SLC43A1 SERPINF1 MCC PKDCC DNAH1 EFHD1

6.51e-051801696c4068fe47408cfd899131a85fa4b7e5908926f94
ToppCelldroplet-Heart-nan-3m-Endothelial-coronary_vascular_endothelial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MCC SHROOM4 GVINP1 RAPGEF3 PPP1R16B PLCB4

6.71e-05181169692d44892bb15771f0ab5fe61879b204b0acbd9b3
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DAPK1 SMOC2 CRMP1 PTPRG LGI2 PLCB4

6.71e-0518116969d782ba5cf5a172cb4f447763fc50e5b13ef7dd9
ToppCellLV-17._Lymphocyte|LV / Chamber and Cluster_Paper

DOCK2 MYO1G CDK15 ANKRD44 PIK3CD PPP1R16B

6.71e-05181169681fafa69c8c240250a667a5f3b321e8be1b9a288
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_1|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DAPK1 SMOC2 CRMP1 FRMD4A LGI2 WDFY3

6.71e-051811696071f9bb5d39070cdc473d9b0e094d196bc702b56
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_3|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DAPK1 SMOC2 CRMP1 PTPRG LGI2 PLCB4

6.92e-051821696eb138aa1dca9373f1586600f258df06dcf56d81f
ToppCelldroplet-Heart-nan-3m-Endothelial-endothelial_cell_of_coronary_artery|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MCC SHROOM4 GVINP1 RAPGEF3 PPP1R16B PLCB4

6.92e-05182169681279877b920b5a1bc991a07d3031d6458700fe3
ToppCellAdult-Mesenchymal-airway_smooth_muscle_cell-D175|Adult / Lineage, Cell type, age group and donor

RIPK4 SMOC2 CRMP1 EFHD1 RPS6KA6 ABCC2

6.92e-051821696ad4d74d8b19976e1ccc3c5ba8013199338cf6fd8
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DAPK1 SMOC2 CRMP1 FRMD4A LGI2 WDFY3

7.13e-051831696738e94b50c4c08c727d4eed0708dda08aa6891b4
ToppCellfacs-Pancreas-Exocrine-18m-Endothelial-endothelial_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DYSF EHD2 GPR146 RAPGEF3 PPP1R16B PLTP

7.13e-051831696c9d9d7dd629ce6787502103b158a07e8684a66f8
ToppCellCOPD-Epithelial-ATII|World / Disease state, Lineage and Cell class

PDE4C SYNE1 FASN KANK1 PTPN13 PTPRG

7.13e-0518316968e9aab4eeec2e282c2cab9bfca6dbf40d660c7b9
ToppCellfacs-Pancreas-Exocrine-18m-Endothelial|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DYSF EHD2 GPR146 RAPGEF3 PPP1R16B PLTP

7.13e-051831696c7ef8ee2b3fcfa69cea0fdcb2041674b832933db
ToppCellfacs-Pancreas-Exocrine-18m-Endothelial-nan|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DYSF EHD2 GPR146 RAPGEF3 PPP1R16B PLTP

7.13e-05183169692eee4bdd84965ae0bd1ed1c7f26a3b83ad0cdac
ToppCellAdult-Immune-interstitial_macrophage_(C1Q_positive)-D175|Adult / Lineage, Cell type, age group and donor

DOCK2 EXOC8 FRMD4A LGI2 WDFY3 PLTP

7.57e-051851696ab5704b96f1d368911308797d10c7c52766ab134
ToppCellLPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_3|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ITGA11 SYNE1 FRMD4A KANK1 LGI2 EFHD1

7.80e-0518616964780af76237d7af2abbe2d8d5530cdf53e3ed0b7
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

RTTN FRMD4B GDA GLG1 PPP1R16B ABCC2

7.80e-0518616965784d255e9ca449d375d81938d0fbbd8a7eb44f6
ToppCellfacs-Trachea-nan-24m-Mesenchymal|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGA11 SERPINF1 SMOC2 LGI2 EFHD1 C4B

8.03e-05187169671385068e3fd0bfa7822ae176113a49460c8636b
ToppCellfacs-Trachea-nan-24m-Mesenchymal-fibroblast|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGA11 SERPINF1 SMOC2 LGI2 EFHD1 C4B

8.03e-051871696b930d5f7d410ac1f340babec5c937388f64cafc0
ToppCellfacs-Trachea-nan-24m-Mesenchymal-nan|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGA11 SERPINF1 SMOC2 LGI2 EFHD1 C4B

8.03e-051871696e891e571f6bb9433a0046215de6cabd89ed1effc
ToppCellP07-Hematopoietic-Erythroid|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

HLA-DOA SLC43A1 SPTB ARL9 GDA

8.41e-0511716951820396bd590020a83fac3416d559e32f41eab61
ToppCellP07-Hematopoietic-Erythroid-enucleate_erythrocyte|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

HLA-DOA SLC43A1 SPTB ARL9 GDA

8.41e-05117169543c7257788fe3d53d663365d1754aee6ad88bbc5
ToppCellfacs-Heart-LV-3m-Endothelial|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MCC EHD2 PTPRG RAPGEF3 PPP1R16B PLCB4

8.52e-051891696d424d2554595b2304219f7324406b401711af7c2
ToppCellfacs-Heart-LV-3m-Endothelial-endothelial_cell_of_coronary_artery|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MCC EHD2 PTPRG RAPGEF3 PPP1R16B PLCB4

8.52e-051891696393ec5954a12d6cf67bb435dcc34ff0b14c81e9f
ToppCellfacs-Heart-LV-3m-Endothelial-coronary_vascular_endothelial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MCC EHD2 PTPRG RAPGEF3 PPP1R16B PLCB4

8.52e-051891696bec57459ad4bab15b2532b57722549fec2e771fb
ToppCellAdult|World / Lineage, Cell type, age group and donor

DOCK2 RNF213 PPP4R4 FASN DHFR ALOX15B

8.52e-0518916965cd285bfad973125d46d704fec18b21266a63379
ToppCellChildren_(3_yrs)-Immune-interstitial_macrophage_(C1Q_positive)|Children_(3_yrs) / Lineage, Cell type, age group and donor

DOCK2 GPR155 FRMD4B FRMD4A LGI2 PLTP

8.77e-051901696f573fef3762a30c38cf8fa7f45df0ffbb49dc873
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L4-6_SST_MTHFD2P6|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DAPK1 FRMD4B ANKRD44 OTOF PIK3CD ADAMTS20

9.02e-0519116969c0ee270209b02043393416ecc9a81ddedfbb8b6
ToppCellCiliated-cil-3|World / Class top

DYNC2H1 SYNE1 DNAH1 FAM47E DNAH9 PLTP

9.29e-0519216964989ebb8812b8af1870599acd932849122c05a29
ToppCellfacs-Lung-nan-3m-Endothelial-Capillary_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MCC ANKRD44 FRMD4A PTPRG GCC2 PLTP

9.29e-0519216964bab9754cfd8b9c2d7cc1490e8a29f58c3c26f6c
ToppCellfacs-Aorta-Heart-3m|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYO1G USP9X SYNE1 PTPRG GLG1 LYPLA1

9.29e-0519216961ccc47792edf9ee23501c8e2165d11271636b66a
ToppCellnucseq-Endothelial-Endothelial_Vascular-Endothelial_capillary|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

MCC DYSF PTK2 SHROOM4 PTPRG PLCB4

9.55e-051931696f582e939e3e08a8a3f71deec78c33715be8faa51
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DAPK1 FRMD4B ANKRD44 OTOF PIK3CD ADAMTS20

9.55e-051931696d1445b8bf2bab36e1a326ddb2a528151db016c7d
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DAPK1 FRMD4B ANKRD44 OTOF PIK3CD ADAMTS20

9.55e-051931696010717ca052b6c8a525a43aaeffddea0d1113e63
ToppCellRV-08._Macrophage|RV / Chamber and Cluster_Paper

DOCK2 DAPK1 FRMD4B PIK3CD BUB1B PLTP

9.55e-05193169612bf98a280f87e4d8f0c6887dfc855da72e47ac1
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

SYNE1 FRMD4B FASN KANK1 PTPN13 PTPRG

9.83e-05194169697534c8bba895a7913665e03ae4e5c4a6ad71daf
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SYNE1 DYSF FRMD4B ASAP1 PTPRG PPP1R16B

1.04e-0419616968f2031b1a9232c389517fbf3c29f47f9468b0077
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Endothelial|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SYNE1 DYSF FRMD4B ASAP1 PTPRG PPP1R16B

1.04e-04196169648b4a9cea97a55190217deaf51bf867608c5a9a7
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SYNE1 DYSF FRMD4B ASAP1 PTPRG PPP1R16B

1.04e-041961696473980c827443464d08a0be28c53e3536369b12a
ToppCell10x3'2.3-week_17-19-Hematopoietic|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

SLC43A1 SPTB STK11 FRMD4A RNF123 CDC27

1.04e-0419616962aeb792e7685e33e3543a6974be790980a41ed8c
ToppCell10x3'2.3-week_17-19-Hematopoietic-erythroid|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

SLC43A1 SPTB STK11 FRMD4A RNF123 CDC27

1.07e-041971696b71da7f2fd8d526fb6e5d57e60fc08acdd8dbefb
ToppCell5'-GW_trimst-2-LargeIntestine-Hematopoietic-Myeloid-Macrophages|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DOCK2 HLA-DOA RNF213 DAPK1 FRMD4B FRMD4A

1.07e-04197169610190b877bf46ba2163d203df9dd3b498c66e52f
ToppCellInfluenza-Influenza_Severe-Myeloid-pDC|Influenza_Severe / Disease, condition lineage and cell class

HLA-DOA SERPINF1 MCC NBEA ZNF469 KANK1

1.07e-041971696e8e6f71e6dc8a695e4321a18543c1df63dd62f3e
ToppCellCOVID-19-lung-Macrophage_VCANhi_FCN1hi|lung / Disease (COVID-19 only), tissue and cell type

DOCK2 MYO1G RNF213 DYSF OTOF PIK3CD

1.07e-041971696a0f8a992282a6d64890f5574c7c9741fcb38dadd
ToppCell3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PDE4C SYNE1 HMGCR FASN PTPN13 ALOX15B

1.07e-041971696bf10727fbe90b71d2ac60a11711e5f0701b3799d
ToppCellCOVID-19-lung-Macrophage_VCANhi_FCN1hi|COVID-19 / Disease (COVID-19 only), tissue and cell type

DOCK2 MYO1G RNF213 DYSF OTOF PIK3CD

1.10e-041981696ea34096bee852a7e996f097fa279381afa8f86ff
ToppCellBronchial-NucSeq-Epithelial-Epi_alveolar-AT2|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

FRMD4B PPP4R4 KANK1 PTPN13 PTPRG ALOX15B

1.10e-041981696f948391296c261c473d339069a6d0f20ccd6f38f
ToppCellParenchymal-NucSeq|Parenchymal / Cell types per location group and 10X technology with lineage, and cell group designations

LRRC37A3 PTK2 KANK1 PTPN13 PTPRG WDFY3

1.10e-0419816961996373bdccc55aac347d349bd22f6aad6d0c668
ToppCellParenchymal-NucSeq-Epithelial-Epi_alveolar-AT2|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

FRMD4B FASN KANK1 PTPN13 PTPRG ALOX15B

1.10e-0419816962e2a4e1756bba6f4fbe529559a97d2993c890b4b
ToppCell(11)_FOXN4+-(2)_GFP_FOXI1|(11)_FOXN4+ / shred by cell type by condition

VPS13C KIF20B PTPN13 MAP4K5 GCC2 CDC27

1.10e-04198169676d40b8c2f8399725b3a62ee2ae0896559cf91eb
ToppCell10x3'2.3-week_17-19-Hematopoietic-erythroid-early_erythroid|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

SLC43A1 SPTB PKDCC GAL DHFR CDC27

1.10e-0419816968d900a17667a41bdfa683a34275fe4c059f6a8ef
ToppCellControl_saline|World / Treatment groups by lineage, cell group, cell type

FOXN2 PTK2 CRMP1 PTPRG PLCB4 PLTP

1.13e-04199169611c9c1779caceb725ecccf3f23b7d4e6dbd1af64
ToppCelldistal-3-mesenchymal-Adventitial_Fibroblast|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

ITGA11 SERPINF1 SMOC2 GSTM3 GAL PLTP

1.13e-041991696547a7c30abc730af2670aee00c7a6af60426c9ac
ToppCellTracheal-NucSeq|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations

LRRC37A3 NBEA CLASP2 PTK2 PLCB4 WDFY3

1.13e-04199169694b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCelldistal-mesenchymal-Adventitial_Fibroblast-3|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

ITGA11 SERPINF1 SMOC2 GSTM3 GAL PLTP

1.13e-0419916966e8a44e46b46e87b81dbfc56fcbbcde166fd00fe
ToppCellSepsis-ICU-SEP-Lymphocyte-T/NK-MAIT|ICU-SEP / Disease, condition lineage and cell class

SHROOM4 FRMD4A KANK1 TRANK1 RAPGEF3 MOCOS

1.13e-0419916962f10622319c6146dfed8cfe3844180c1e1d56e94
ToppCellLPS_IL1RA-Endothelial-Endothelial|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

RNF213 PTK2 EHD2 GPR146 SHROOM4 PLCB4

1.16e-04200169672ea9882a8ed26fa1534aeb6ba0d1897dccc20c5
ToppCellNeuronal-Excitatory-eA(LAMP5_LINC00507)-FREM3---L2-3|Neuronal / cells hierarchy compared to all cells using T-Statistic

LMF1 PDE4C KCNG3 PPP4R4 ZNF469 PTPN13

1.16e-0420016969c89e91bb630cc306a820927a36ea6fb3d13e9d7
ToppCellLPS_IL1RA-Endothelial|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

RNF213 PTK2 EHD2 GPR146 SHROOM4 PLCB4

1.16e-0420016965c092b2ecc081b5d04476c56333c338cd89ab984
ToppCellParenchymal-10x3prime_v2-Epithelial-Epi_submucosal-gland|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

HLA-DOA LRIG3 RNF123 DHFR FAM47E MOCOS

1.16e-04200169668b0f987c4fb8078675475f4f1e71302f832ef69
ToppCellControl_saline-Endothelial-Endothelial|Control_saline / Treatment groups by lineage, cell group, cell type

FOXN2 PTK2 CRMP1 PTPRG PLCB4 PLTP

1.16e-042001696e77eba6172cabf85b8028638ed35299f2f079cd8
ToppCellParenchymal-10x3prime_v2-Epithelial-Epi_submucosal-gland-SMG_Duct|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

HLA-DOA LRIG3 RNF123 DHFR FAM47E MOCOS

1.16e-0420016961b527bebbca1ef8c52449e40beb9358e37494e04
ToppCellNeuronal-Excitatory-eA(LAMP5_LINC00507)-FREM3-|Neuronal / cells hierarchy compared to all cells using T-Statistic

LMF1 PDE4C KCNG3 PPP4R4 ZNF469 PTPN13

1.16e-0420016968821574d17b55dfea3ca0204e6b4c0ca6b19588a
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW12-OPC_related-Oligodendrocyte/OPC|GW12 / Sample Type, Dataset, Time_group, and Cell type.

TPRA1 PKDCC EHD2 DHFR2 TSHZ1 DNAH9

1.16e-0420016964db894cfb80fd1f9e01133f345eefd78edd4bc43
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW12-OPC_related|GW12 / Sample Type, Dataset, Time_group, and Cell type.

TPRA1 PKDCC EHD2 DHFR2 TSHZ1 DNAH9

1.16e-042001696d46a19274c2836ce7494790ce513764dedcadc79
ToppCellLPS_only-Endothelial-Endothelial-Alv_Cap|LPS_only / Treatment groups by lineage, cell group, cell type

RNF213 DYSF CRMP1 EHD2 GPR146 PLAGL1

1.16e-042001696432384faeade8e609154fab3d96c955a8ec868dd
ToppCellControl_saline-Endothelial|Control_saline / Treatment groups by lineage, cell group, cell type

FOXN2 PTK2 CRMP1 PTPRG PLCB4 PLTP

1.16e-0420016963372c488a39fe812fa94e4f0564594186fea3db5
ToppCellNeuronal-Excitatory-eA(LAMP5_LINC00507)-FREM3--|Neuronal / cells hierarchy compared to all cells using T-Statistic

LMF1 PDE4C KCNG3 PPP4R4 ZNF469 PTPN13

1.16e-04200169696b1d2e70fbbba744fd4356a70efcf356aca9abc
DiseaseJeune thoracic dystrophy

DYNC2H1 WDR19

1.87e-0441662cv:C0265275
Diseasefasting blood glucose measurement, glucose tolerance test, fasting blood insulin measurement

VPS13C MAP4K5

3.11e-0451662EFO_0004307, EFO_0004465, EFO_0004466
Diseasereaction time measurement

MYO1G GPR155 ATP13A1 PLA2G3 LRRC37A2 MCC DYSF ANKRD44 EFHD1 DHFR TSHZ1 CDC27

3.69e-0465816612EFO_0008393
DiseaseNeoplasms, Therapy-Associated

DAPK1 RAD9A

4.65e-0461662C0086696
DiseaseNeoplasms, Second Primary

DAPK1 RAD9A

4.65e-0461662C0085183
DiseaseTreatment related secondary malignancy

DAPK1 RAD9A

4.65e-0461662C0877578
Diseaselimb-girdle muscular dystrophy (implicated_via_orthology)

DYSF OTOF

6.49e-0471662DOID:11724 (implicated_via_orthology)
DiseaseAutistic Disorder

GPR155 PDE4A MCC NBEA SEZ6L2 DHFR C4B

7.19e-042611667C0004352
Diseaseurate measurement, bone density

SYNE1 MCC PKDCC CLASP2 RIPK4 DHX33 DNAH1 PTPRG MAP4K5 PPP1R16B DNAH9

7.99e-0461916611EFO_0003923, EFO_0004531
Diseaseleptin measurement

DOCK2 SPTB SMOC2 MAP4K5

1.15e-03811664EFO_0005000
Diseaseplatelet component distribution width

MYO1G SCN11A SYNE1 RTTN PSMD2 SMOC2 ASAP1 TRANK1 BAZ2A RAPGEF3 GCC2 PPP1R16B

1.22e-0375516612EFO_0007984
DiseaseJeune thoracic dystrophy

DYNC2H1 WDR19

1.67e-03111662C0265275
Diseasecerebral cavernous malformation (implicated_via_orthology)

RNF213 STK24

1.67e-03111662DOID:0060669 (implicated_via_orthology)
Diseasefree cholesterol to total lipids in very small VLDL percentage

HMGCR MAP4K5 PLTP

1.83e-03431663EFO_0022290
DiseaseMalignant neoplasm of salivary gland

SERPINF1 DAPK1 EFHD1

2.09e-03451663C0220636
DiseaseSalivary Gland Neoplasms

SERPINF1 DAPK1 EFHD1

2.36e-03471663C0036095
DiseaseAdenoid Cystic Carcinoma

SMC1A SERPINF1 DAPK1 EFHD1

2.49e-031001664C0010606
Diseasephospholipids in medium LDL measurement

HMGCR MAP4K5 PLTP

2.66e-03491663EFO_0022183
Diseasetype 2 diabetes mellitus (implicated_via_orthology)

SERPINF1 HMGCR PIK3CD ADAMTS20

2.97e-031051664DOID:9352 (implicated_via_orthology)
DiseaseHypertriglyceridemia

LMF1 PLTP

3.15e-03151662C0020557
DiseaseYKL40 measurement

PKDCC MAP4K5

3.15e-03151662EFO_0004869
Diseasetotal lipids in LDL measurement

HMGCR MAP4K5 PLTP

3.16e-03521663EFO_0022308
DiseaseDupuytren Contracture

ITGA11 PTK2 DHX8 PTPRG

3.29e-031081664EFO_0004229
Diseaseosteosarcoma (is_implicated_in)

SERPINF1 GSTM3

3.58e-03161662DOID:3347 (is_implicated_in)
Diseasetriglyceride measurement, intermediate density lipoprotein measurement

LMF1 GPR146 MAP4K5 PLTP

3.63e-031111664EFO_0004530, EFO_0008595
Diseaseasthma, response to diisocyanate

DYNC2H1 FTCDNL1 ASAP1 PIK3CD EFHD1 CTDP1

3.70e-032611666EFO_0006995, MONDO_0004979
Diseasetriacylglycerol 52:2 measurement

RIPK4 LGI2 MAP4K5

3.70e-03551663EFO_0010414
Diseasefree cholesterol to total lipids in large HDL percentage

HMGCR MAP4K5 PLTP

3.90e-03561663EFO_0022279
Diseasecholesteryl esters to total lipids in large VLDL percentage

HMGCR MAP4K5 PLTP

3.90e-03561663EFO_0022250
Diseasemuscular dystrophy (is_implicated_in)

SYNE1 DYSF

4.05e-03171662DOID:9884 (is_implicated_in)
DiseaseMoyamoya Disease

RNF213 PCNT

4.05e-03171662C0026654
Diseasefree cholesterol to total lipids in medium VLDL percentage

HMGCR MAP4K5 PLTP

4.10e-03571663EFO_0022284
Diseasemigraine disorder

SCN11A RNF213 NBEA ASAP1 FRMD4A KANK1 PCMT1

4.21e-033571667MONDO_0005277
Diseasephospholipids in LDL measurement

HMGCR MAP4K5 PLTP

4.30e-03581663EFO_0022294
Diseaseinformation processing speed, response to cranial radiation therapy

SMOC2 FRMD4A NSMCE4A

4.30e-03581663EFO_0004363, EFO_0010950
Diseasefree cholesterol to total lipids in very large VLDL percentage

HMGCR MAP4K5 PLTP

4.51e-03591663EFO_0022289
DiseaseChild Behaviour Checklist assessment

RIPK1 KANK1

4.54e-03181662EFO_0005661
Diseaseimmature platelet measurement

MYO1G RTTN ASAP1 BAZ2A

4.65e-031191664EFO_0803541
Diseasetriglyceride measurement, high density lipoprotein cholesterol measurement

LMF1 HMGCR DNAH1 GPR146 MAP4K5 PLTP

4.68e-032741666EFO_0004530, EFO_0004612
DiseasePROSTATE CANCER, HEREDITARY, 1

DOCK2 HLA-DOA TSHZ1

4.73e-03601663C4722327
Diseasecolorectal cancer (is_implicated_in)

MCC PTPN13 PIK3CD BUB1B

4.93e-031211664DOID:9256 (is_implicated_in)
Diseasesphingomyelin measurement

PKDCC FRMD4B CERS5 RAPGEF3 MAP4K5 PLTP

5.02e-032781666EFO_0010118
Diseaseneck circumference

ADAMTS20 ANKRD52

5.05e-03191662EFO_0011043
Diseasetoxic shock syndrome (is_marker_for)

SERPINF1 IL19

5.05e-03191662DOID:14115 (is_marker_for)
Diseaseend stage renal disease (implicated_via_orthology)

HMGCR ABCC2

5.59e-03201662DOID:783 (implicated_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
FIHDALLEAILGKET

PTPRG

1111

P23470
VDLFGIADLAHLLLF

BUB1B

951

O60566
SKVLADVAIIFSGLH

CTDP1

631

Q9Y5B0
DLHISNKLFVLDAGA

DAPK1

921

P53355
LAALEKFEQLTLDGH

ALG1

296

Q9BT22
LKDLEEHIISAGLAD

CUL5

311

Q93034
AHFAGSLLLLVVDQK

CATSPERD

101

Q86XM0
AKNLSHLDTVLGALD

COPS3

36

Q9UNS2
LSGFHALRADLEKLT

C4B

1491

P0C0L5
LDHFSKSLFLDLVEL

ACOX3

366

O15254
KAAVLAFLVHELNGS

BAZ2A

971

Q9UIF9
ALKHADVGVALLANA

ATP13A1

871

Q9HD20
FALASHLIEAKLEGH

EHD2

506

Q9NZN4
SVFLDKLTAGHLEEL

GVINP1

1351

Q7Z2Y8
TSLAEKLLFHGENIE

ANKRD20A5P

146

A0PJZ0
KGLLLIFVVDSADHS

ARL9

86

Q6T311
GTLISKNFAALLEEH

SMDT1

81

Q9H4I9
GFALVLDAHENLLLA

AP5S1

121

Q9NUS5
LEFGAKAQLEVHLAS

ASB11

151

Q8WXH4
VGSLAEKIQALHFSL

ASB6

351

Q9NWX5
NEKVLGLLLAHSADV

ANKRD52

86

Q8NB46
CQLLHKFGADLLATD

ANKRD46

61

Q86W74
TLHTDILFGLIKDVA

DHX16

526

O60231
LDQLKLAFTLDHETG

DIS3L2

551

Q8IYB7
FADVLVHRLLAAALG

DIS3L2

706

Q8IYB7
LHDVSDFLLEAAKLA

CERS5

246

Q8N5B7
EEKGLISAFTIAHEL

ADAMTS20

391

P59510
RVELAAHKSLAGAEL

QSOX2

336

Q6ZRP7
IKDSLLDGHFVLATL

RAD9A

251

Q99638
IFSALSQLLEHGLDL

KCNG3

336

Q8TAE7
VAVEHALLALKFILA

ANO10

596

Q9NW15
LTELHKDSFEGLLSL

LRRC37A3

901

O60309
QELHSLGAALAEKLD

KRBA1

801

A5PL33
ASEHLELIFGLDLKE

MAGEB10

156

Q96LZ2
DTIDFHLLTALGKVS

KIAA0895

456

Q8NCT3
LTELHKDSFEGLLSL

LRRC37A2

901

A6NM11
LTELHKDSFEGLLSL

LRRC37A

901

A6NMS7
LSSHAAKLGAQLADL

FN3KRP

96

Q9HA64
ITKKAFTGLDALEHL

LRIG3

401

Q6UXM1
EFRKHGIGSLLLESL

NAA60

106

Q9H7X0
ISFGIFGLDKHLIIL

GPR155

706

Q7Z3F1
IHFLDKELTGLNEAL

HMGCR

111

P04035
QLEVHAAAIKSLGEL

IL19

146

Q9UHD0
ATELDRHKILLHLGF

GPR137C

156

Q8N3F9
LSGLALDHKVTGDLF

SLC43A1

236

O75387
ILDAFKASGDHNILI

DDX58

681

O95786
LALAKGGLSDDHVLI

CWF19L1

351

Q69YN2
LLIAAGQHFEDSKEL

MAP3K6

401

O95382
LTIGADLHFAKGLRE

PLTP

456

P55058
VADSGLTLKGFLFLH

RHOT1

241

Q8IXI2
LEILAALFAAAIHDV

PDE4A

461

P27815
LEILAALFASAIHDV

PDE4C

416

Q08493
DGIKLDLSHEFSLVA

KIF20B

31

Q96Q89
FAAISALKVGADLSH

NAXD

91

Q8IW45
FLHLLTGNLALLADE

NELFB

461

Q8WX92
SIALEAGHKDIAVLL

KANK1

1306

Q14678
HLKEILLFVNAEAFS

MIR1-1HG

56

Q9H1L0
VHLEKGDLSTALEVA

LRPPRC

831

P42704
GLAHAIRLLLEFTDT

GSTM3

16

P21266
EDGTISFLDVIALKH

MOCOS

316

Q96EN8
ELAHLKSFVASLQLG

ABCC2

1411

Q92887
LDEIGHIKLTDFGLS

RPS6KA6

206

Q9UK32
LAAFKGHTECVEALI

ANKRD44

606

Q8N8A2
KSIFLHHLEIELAAG

ITGA11

916

Q9UKX5
ELGTAVALIKTHDLD

PCDHGB3

361

Q9Y5G1
EFILLGLTDHAELKA

OR5J2

11

Q8NH18
GLTDHAELKAVLFVV

OR5J2

16

Q8NH18
GLDLTFIIHALLVKD

EXOC8

536

Q8IYI6
LALELHKTQGTLEGF

PCNT

1326

O95613
LAAKEALGHLSLAEV

OBSCN

5516

Q5VST9
LVGSLEKNEFITLAH

PAPOLA

401

P51003
DNFEEIVKLLLSHGA

PPP1R16B

111

Q96T49
LAKELLDLVASHFNL

FRMD4A

41

Q9P2Q2
ARELLDLVASHFNLK

FRMD4B

81

Q9Y2L6
ASLLNLFDKGILATH

DNAH1

681

Q9P2D7
GAKELHLFDIILTSV

DYNC2H1

2541

Q8NCM8
ALHLLLLFAAGAEKL

GLG1

16

Q92896
KLLFGHSTEGDILEL

ENOPH1

161

Q9UHY7
HSAALASLKGDIVEL

MCC

21

P23508
LAGIAAIKAHLDILV

HLA-DOA

86

P06340
ENDFLHSLLGKVIAS

DOCK2

356

Q92608
KVLIHGFTQSLLLDD

COG1

691

Q8WTW3
DHILETLSALAVDLG

GNE

401

Q9Y223
LISHLGELKLADFGL

CDK15

231

Q96Q40
KFEALAAHDALVELS

FH

311

P07954
IEFLSFLHLKEAGAL

GAL

91

P22466
GAHFLSRSLDDALKL

DHFR

86

P00374
AASALGAAVRLHLEL

F8A1;

121

P23610
DHLILQASLKGELEA

GCC2

1241

Q8IWJ2
KGAVDALAAALAHIS

DDX50

556

Q9BQ39
AIAQLDLLGALEHKD

DHX33

471

Q9H6R0
HNVIFTLDSLLKGDL

ASAP1

141

Q9ULH1
AARKATAAVIFLHGL

LYPLA1

16

O75608
FLLIFHKAAAGELQE

EFHD1

151

Q9BUP0
ELKEAAGSLLHLAGI

FOXN2

396

P32314
TGALHLARLAKDSAA

IFITM5

106

A6NNB3
GAHFLARSLDDALKL

DHFR2

86

Q86XF0
DHLLGVSDSGKIVFL

GDA

31

Q9Y2T3
SVDKLGLAEDLVLHV

FTCDNL1

66

E5RQL4
LHVVEGLLKTALDFH

DNAH9

446

Q9NYC9
EHAFKLLDIAGNLLE

DNAH9

541

Q9NYC9
AAHIAVLDSELFLEK

FAM135B

1381

Q49AJ0
LGLLHFVKDFSKLLA

GPR146

271

Q96CH1
SGLAALAKVLLSLEH

FASN

336

P49327
LLGHEFVLTEELDKA

CDC27

606

P30260
ITEAALALKLGHSEL

DYSF

751

O75923
GHFTSAEDLNLLIAK

DDB1

21

Q16531
TFLKGLGAVILVHAE

CRMP1

186

Q14194
LSGFHALRADLEKLT

C4A

1491

P0C0L4
GNHIRKALLDIADLF

CPT1B

751

Q92523
HLGINDKDLAEFVIS

DHX8

41

Q14562
ILLTDHGDVKLADFG

MAP4K5

146

Q9Y4K4
FELTGKVEAELHLLT

OTOF

1901

Q9HC10
GLVEHHLFALATLKD

PTPN13

606

Q12923
ILKSLGELGLEHFQA

OGFR

216

Q9NZT2
ELEKGSLFLVDHGIL

ALOX15B

281

O15296
LKLLAFHLTSEEGAD

RTTN

776

Q86VV8
QFLSVLLTEEAKGHL

RTTN

1796

Q86VV8
LADLHGTVAFKDFIL

FAM47E

346

Q6ZV65
ILEGHLGVTKELLAF

USP9X

1426

Q93008
LLFDQLHEGAKALDV

PCMT1

71

P22061
ALELGSTEVLLDHLK

PLAGL1

126

Q9UM63
DLFGDLLLKQALESH

PLCB4

426

Q15147
AAVALKAVDFSGHDL

PKDCC

161

Q504Y2
DESILISLSFHLGKL

PPP4R4

306

Q6NUP7
IHAVANIGTALKFLE

SYNE1

86

Q8NF91
VKDSLFFLHELGEQL

SYNE1

7296

Q8NF91
AEFVDIDGKSHLILS

LGI2

376

Q8N0V4
ASVALGLDLRELHKA

MAP3K21

731

Q5TCX8
LAATLVLHLALADGA

LTB4R2

56

Q9NPC1
KLLSAGIFSDIHLLA

RIMOC1

196

A6NDU8
NVLLSEHGEVKLADF

STK24

161

Q9Y6E0
DGGLFLLADVSHKVI

PIWIL2

371

Q8TC59
HLGKGEAIEAILAAL

PSMD2

566

Q13200
LLSALGLALADVVHE

OPLAH

516

O14841
LTAAHALAVDAKNLL

PTK2

1021

Q05397
FGSTHAEALLKAAIE

NBEA

2086

Q8NFP9
LQSHAKAIVLVLFGA

PTCH2

681

Q9Y6C5
RAISSLDLLGDFKHA

SHROOM4

1016

Q9ULL8
ELLKNLVLTGFSHID

UBA2

31

Q9UBT2
LVLTGFSHIDLIDLD

UBA2

36

Q9UBT2
VLDAHFLVLASDLGK

NSMCE4A

131

Q9NXX6
AALFEGKVQLHLIES

WDR19

441

Q8NEZ3
KISDLGVAEALHPFA

STK11

191

Q15831
VASEALAELLHGALL

SEZ6L2

46

Q6UXD5
GHLAAVEVLLKLGAD

IQANK1

236

A8MXQ7
VDNDFHIKIADLGLA

RIPK1

146

Q13546
SFLAKDAQGLALIHA

PLA2G3

46

Q9NZ20
LALDSGASLLHLAVE

RIPK4

481

P57078
HFLILLFSKDEDISL

SSRP1

271

Q08945
GALNRKESFLLLSLH

CLEC18A

41

A5D8T8
GALNRKESFLLLSLH

CLEC18B

41

Q6UXF7
GALNRKESFLLLSLH

CLEC18C

41

Q8NCF0
FQHLRLLDGALKLSA

CLASP2

131

O75122
AGKIDLLRDSHIFQL

RNF213

1221

Q63HN8
FLLLGVKVHSLSSEE

WFDC5

191

Q8TCV5
ELAAVLLFEPHSKAG

RAPGEF3

256

O95398
SVIILGLAFGHLESK

TPRA1

131

Q86W33
GLHDIKNAELALFEL

TTC13

191

Q8NBP0
HLLAADVLLGEDASL

WDFY3

2016

Q8IZQ1
DEISILLLGVAHFKG

SERPINF1

201

P36955
GAKKHEFLTSVLDAL

SMOC2

306

Q9H3U7
TLTRLAAILAKHFAD

RNF123

896

Q5XPI4
AAILAKHFADARIVG

RNF123

901

Q5XPI4
QISLLIGKGLHEFDS

PIK3CD

116

O00329
GEKTVAALALLFAIH

SMC1A

1131

Q14683
LKVSFASLDLVLHLE

VPS13C

1531

Q709C8
LLSAEFGKHLLEVED

SPTB

551

P11277
LTGFHLLDGKTHLFI

nan

266

Q6ZUG5
LLDGKTHLFILEGLA

nan

271

Q6ZUG5
KDDFVDLLLQHIGTS

PPP6R1

146

Q9UPN7
FRSLGELDLHKLAHT

ZNF469

3096

Q96JG9
ILLSSGALIFEDVHL

SCN11A

1066

Q9UI33
EIKADIGFSFLSHLL

TRANK1

511

O15050
LALLLHESLDSGEKF

TERB1

301

Q8NA31
HVLEIAALKGSASEA

ULK1

856

O75385
ISHLETHLGFSLKDL

TSHZ1

986

Q6ZSZ6
LFGQHLATEVIFKAL

TOR1B

76

O14657
SVLLAFSVLGELHSK

ZW10

226

O43264
IHLAGKLLASDAEAL

LMF1

481

Q96S06
NHLLGSDKAAVSALL

MYO1G

661

B0I1T2