Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	complement binding	CFH CR2 CFHR4	5.07e-05	32	45	3	GO:0001848
GeneOntologyMolecularFunction	extracellular matrix constituent conferring elasticity	FBN1 FBN2	3.23e-04	12	45	2	GO:0030023
GeneOntologyMolecularFunction	complement component C3b binding	CFH CFHR4	3.23e-04	12	45	2	GO:0001851
GeneOntologyMolecularFunction	glycosaminoglycan binding	CFH FBN1 APOH SPOCK3 CFHR4	3.31e-04	268	45	5	GO:0005539
GeneOntologyMolecularFunction	structural molecule activity conferring elasticity	FBN1 FBN2	4.44e-04	14	45	2	GO:0097493
GeneOntologyMolecularFunction	metalloendopeptidase inhibitor activity	TIMP1 SPOCK3	5.84e-04	16	45	2	GO:0008191
GeneOntologyMolecularFunction	heparin binding	CFH FBN1 APOH CFHR4	9.07e-04	192	45	4	GO:0008201
GeneOntologyMolecularFunction	opsonin binding	CFH CFHR4	1.44e-03	25	45	2	GO:0001846
GeneOntologyMolecularFunction	heparan sulfate proteoglycan binding	CFH CFHR4	1.94e-03	29	45	2	GO:0043395
GeneOntologyBiologicalProcess	retinal pigment epithelium development	CFH MFSD2A CFHR4	1.08e-06	10	44	3	GO:0003406
GeneOntologyBiologicalProcess	complement activation, alternative pathway	CFH CR2 CFHR4	8.57e-06	19	44	3	GO:0006957
GeneOntologyBiologicalProcess	bone development	CFH PAPPA2 FBN1 CR2 ADAMTS7 CFHR4	1.95e-05	264	44	6	GO:0060348
GeneOntologyBiologicalProcess	regulation of complement activation	CFH CR2 CFHR4	2.56e-05	27	44	3	GO:0030449
GeneOntologyBiologicalProcess	sequestering of TGFbeta in extracellular matrix	FBN1 FBN2	2.66e-05	4	44	2	GO:0035583
GeneOntologyBiologicalProcess	skeletal system development	CFH PAPPA2 FBN1 FBN2 CR2 TIMP1 ADAMTS7 CFHR4	4.10e-05	615	44	8	GO:0001501
GeneOntologyBiologicalProcess	activation of membrane attack complex	CFH CFHR4	6.64e-05	6	44	2	GO:0001905
GeneOntologyBiologicalProcess	inflammatory response to wounding	CFH TIMP1 CFHR4	7.25e-05	38	44	3	GO:0090594
GeneOntologyBiologicalProcess	regulation of complement activation, alternative pathway	CFH CFHR4	9.28e-05	7	44	2	GO:0030451
GeneOntologyBiologicalProcess	maintenance of protein location in extracellular region	FBN1 FBN2	1.24e-04	8	44	2	GO:0071694
GeneOntologyBiologicalProcess	immune complex clearance	CFH CFHR4	1.59e-04	9	44	2	GO:0002434
GeneOntologyBiologicalProcess	monocyte aggregation	CFH CFHR4	1.59e-04	9	44	2	GO:0070487
GeneOntologyBiologicalProcess	cartilage development	CFH CR2 TIMP1 ADAMTS7 CFHR4	1.63e-04	243	44	5	GO:0051216
GeneOntologyBiologicalProcess	sequestering of extracellular ligand from receptor	FBN1 FBN2	2.42e-04	11	44	2	GO:0035581
GeneOntologyBiologicalProcess	energy homeostasis	CFH PASK MFSD2A CFHR4	2.49e-04	144	44	4	GO:0097009
GeneOntologyBiologicalProcess	regulation of humoral immune response	CFH CR2 CFHR4	2.85e-04	60	44	3	GO:0002920
GeneOntologyBiologicalProcess	regulation of complement-dependent cytotoxicity	CFH CFHR4	3.42e-04	13	44	2	GO:1903659
GeneOntologyBiologicalProcess	extracellular regulation of signal transduction	FBN1 FBN2	3.42e-04	13	44	2	GO:1900115
GeneOntologyBiologicalProcess	extracellular negative regulation of signal transduction	FBN1 FBN2	3.42e-04	13	44	2	GO:1900116
GeneOntologyBiologicalProcess	complement activation	CFH CR2 CFHR4	4.49e-04	70	44	3	GO:0006956
GeneOntologyBiologicalProcess	photoreceptor cell development	CFH MFSD2A CFHR4	5.08e-04	73	44	3	GO:0042461
GeneOntologyBiologicalProcess	complement-dependent cytotoxicity	CFH CFHR4	5.24e-04	16	44	2	GO:0097278
GeneOntologyBiologicalProcess	blood coagulation, fibrin clot formation	APOH F13B	5.93e-04	17	44	2	GO:0072378
GeneOntologyBiologicalProcess	retinal rod cell development	CFH CFHR4	5.93e-04	17	44	2	GO:0046548
GeneOntologyBiologicalProcess	leukocyte aggregation	CFH CFHR4	7.43e-04	19	44	2	GO:0070486
GeneOntologyBiologicalProcess	regulation of trophoblast cell migration	FBN2 TIMP1	7.43e-04	19	44	2	GO:1901163
GeneOntologyBiologicalProcess	connective tissue development	CFH CR2 TIMP1 ADAMTS7 CFHR4	7.88e-04	343	44	5	GO:0061448
GeneOntologyBiologicalProcess	trophoblast cell migration	FBN2 TIMP1	8.25e-04	20	44	2	GO:0061450
GeneOntologyBiologicalProcess	retina morphogenesis in camera-type eye	CFH MFSD2A CFHR4	9.35e-04	90	44	3	GO:0060042
GeneOntologyBiologicalProcess	photoreceptor cell differentiation	CFH MFSD2A CFHR4	1.13e-03	96	44	3	GO:0046530
GeneOntologyBiologicalProcess	protein activation cascade	APOH F13B	1.19e-03	24	44	2	GO:0072376
GeneOntologyBiologicalProcess	lipid catabolic process	MFSD2A LRCOL1 STS APOH UGT1A8	1.27e-03	382	44	5	GO:0016042
GeneOntologyCellularComponent	extracellular matrix	FBN1 FBN2 RTBDN APOH TIMP1 ADAMTS7 MUC5AC SPOCK3	6.96e-05	656	45	8	GO:0031012
GeneOntologyCellularComponent	external encapsulating structure	FBN1 FBN2 RTBDN APOH TIMP1 ADAMTS7 MUC5AC SPOCK3	7.11e-05	658	45	8	GO:0030312
GeneOntologyCellularComponent	symbiont cell surface	CFH CFHR4	1.26e-04	8	45	2	GO:0106139
GeneOntologyCellularComponent	other organism part	CFH CFHR4	1.62e-04	9	45	2	GO:0044217
GeneOntologyCellularComponent	microfibril	FBN1 FBN2	3.48e-04	13	45	2	GO:0001527
GeneOntologyCellularComponent	cell surface	CFH RTBDN APOH CR2 EBI3 ADAMTS7 LPAR1 BTN1A1 CFHR4	5.13e-04	1111	45	9	GO:0009986
GeneOntologyCellularComponent	endoplasmic reticulum lumen	FBN1 STS TIMP1 EBI3 ADAMTS7	7.11e-04	332	45	5	GO:0005788
GeneOntologyCellularComponent	external side of plasma membrane	CFH RTBDN CR2 EBI3 BTN1A1 CFHR4	8.15e-04	519	45	6	GO:0009897
GeneOntologyCellularComponent	serine-type endopeptidase complex	CFH CFHR4	8.40e-04	20	45	2	GO:1905370
GeneOntologyCellularComponent	serine-type peptidase complex	CFH CFHR4	1.02e-03	22	45	2	GO:1905286
HumanPheno	Abnormal upper to lower segment ratio	FBN1 FBN2	2.77e-05	3	16	2	HP:0012772
HumanPheno	Arachnodactyly	PAPPA2 FBN1 FBN2 SPIDR HERC1	3.90e-05	133	16	5	HP:0001166
HumanPheno	Slender finger	PAPPA2 FBN1 FBN2 SPIDR HERC1	9.20e-05	159	16	5	HP:0001238
HumanPheno	Long toe	PAPPA2 FBN1 FBN2 SPIDR HERC1	1.20e-04	168	16	5	HP:0010511
HumanPheno	Crumpled ear	FBN1 FBN2	1.38e-04	6	16	2	HP:0009901
MousePheno	white pupil	CFH CFHR4	6.45e-06	2	36	2	MP:0006242
MousePheno	decreased serum complement activity	CFH CFHR4	6.45e-06	2	36	2	MP:0012553
MousePheno	artery occlusion	CFH CFHR4	6.45e-06	2	36	2	MP:0006134
MousePheno	decreased complement C5 level	CFH CFHR4	6.45e-06	2	36	2	MP:0012609
MousePheno	abnormal complement C5 level	CFH CFHR4	6.45e-06	2	36	2	MP:0012608
MousePheno	abnormal hepatic portal vein thrombosis	CFH CFHR4	6.45e-06	2	36	2	MP:0031159
MousePheno	increased susceptilbility to retina ischemic injury	CFH CFHR4	1.93e-05	3	36	2	MP:0012049
MousePheno	abnormal kidney venous thrombosis	CFH CFHR4	1.93e-05	3	36	2	MP:0031161
MousePheno	abnormal response to retina ischemic injury	CFH CFHR4	3.86e-05	4	36	2	MP:0012048
MousePheno	increased susceptibility to type III hypersensitivity reaction	CFH CFHR4	3.86e-05	4	36	2	MP:0005615
MousePheno	decreased circulating complement protein level	CFH CFHR4	3.86e-05	4	36	2	MP:0020216
MousePheno	mesangial cell interposition	CFH CFHR4	3.86e-05	4	36	2	MP:0011512
MousePheno	abnormal brain thrombosis	CFH CFHR4	3.86e-05	4	36	2	MP:0031168
MousePheno	increased creatine level	CFH CFHR4	3.86e-05	4	36	2	MP:0010061
MousePheno	abnormal venous thrombosis	CFH CFHR4	6.42e-05	5	36	2	MP:0031158
MousePheno	abnormal lung thrombosis	CFH CFHR4	6.42e-05	5	36	2	MP:0031167
MousePheno	abnormal circulating complement protein level	CFH CFHR4	9.61e-05	6	36	2	MP:0010215
MousePheno	disorganized photoreceptor outer segment	CFH MFSD2A CFHR4	1.06e-04	36	36	3	MP:0008586
MousePheno	increased total lung capacity	FBN1 ADAMTS7	1.34e-04	7	36	2	MP:0010937
MousePheno	abnormal glomerular capillary thrombosis	CFH CFHR4	1.34e-04	7	36	2	MP:0011508
MousePheno	brain ischemia	CFH CFHR4	1.79e-04	8	36	2	MP:0006080
MousePheno	abnormal complement protein level	CFH CFHR4	2.30e-04	9	36	2	MP:0011566
MousePheno	abnormal creatine level	CFH CFHR4	2.30e-04	9	36	2	MP:0010060
MousePheno	abnormal total lung capacity	FBN1 ADAMTS7	2.86e-04	10	36	2	MP:0002304
MousePheno	abnormal type III hypersensitivity reaction	CFH CFHR4	2.86e-04	10	36	2	MP:0002533
MousePheno	abnormal kidney thrombosis	CFH CFHR4	2.86e-04	10	36	2	MP:0011507
MousePheno	abnormal photoreceptor outer segment morphology	CFH MFSD2A RTBDN CFHR4	4.55e-04	141	36	4	MP:0003729
MousePheno	abnormal visual acuity	CFH CFHR4	4.94e-04	13	36	2	MP:0011832
MousePheno	decreased visual acuity	CFH CFHR4	4.94e-04	13	36	2	MP:0006149
MousePheno	aortic aneurysm	FBN1 TIMP1	5.75e-04	14	36	2	MP:0006278
MousePheno	abnormal Bruch membrane morphology	CFH CFHR4	5.75e-04	14	36	2	MP:0005239
MousePheno	retina detachment	CFH CFHR4	6.63e-04	15	36	2	MP:0003099
MousePheno	decreased a-wave amplitude	CFH RTBDN CFHR4	6.71e-04	67	36	3	MP:0012143
MousePheno	abnormal a-wave amplitude	CFH RTBDN CFHR4	7.31e-04	69	36	3	MP:0012030
MousePheno	abnormal a-wave shape	CFH RTBDN CFHR4	7.63e-04	70	36	3	MP:0012034
MousePheno	amyloid beta deposits	CFH CFHR4	8.56e-04	17	36	2	MP:0003329
MousePheno	hematuria	CFH CFHR4	1.07e-03	19	36	2	MP:0005161
MousePheno	abnormal forelimb morphology	PAPPA2 FBN1 FBN2 TIMP1	1.18e-03	182	36	4	MP:0000550
MousePheno	abnormal radius morphology	PAPPA2 FBN1 FBN2	1.21e-03	82	36	3	MP:0000552
MousePheno	decreased b-wave amplitude	CFH RTBDN CFHR4	1.21e-03	82	36	3	MP:0012144
MousePheno	abnormal ulna morphology	PAPPA2 FBN1 FBN2	1.30e-03	84	36	3	MP:0005108
MousePheno	abnormal glomerular capillary endothelium morphology	CFH CFHR4	1.31e-03	21	36	2	MP:0011453
MousePheno	abnormal b-wave shape	CFH RTBDN CFHR4	1.34e-03	85	36	3	MP:0012035
MousePheno	abnormal b-wave amplitude	CFH RTBDN CFHR4	1.34e-03	85	36	3	MP:0012031
MousePheno	abnormal pelvic girdle bone morphology	PAPPA2 FBN1 FBN2	1.43e-03	87	36	3	MP:0004509
MousePheno	abnormal retina rod bipolar cell morphology	CFH CFHR4	1.58e-03	23	36	2	MP:0006074
MousePheno	abnormal forelimb stylopod morphology	PAPPA2 FBN2 TIMP1	1.68e-03	92	36	3	MP:0003854
MousePheno	abnormal humerus morphology	PAPPA2 FBN2 TIMP1	1.68e-03	92	36	3	MP:0005296
MousePheno	abnormal body height	HERC1 LPAR1	1.86e-03	25	36	2	MP:0001253
MousePheno	decreased body height	HERC1 LPAR1	1.86e-03	25	36	2	MP:0001255
MousePheno	abnormal retina photoreceptor morphology	CFH MFSD2A RTBDN CFHR4	1.86e-03	206	36	4	MP:0001004
MousePheno	abnormal complement pathway	CFH CFHR4	2.02e-03	26	36	2	MP:0002471
MousePheno	abnormal retina photoreceptor layer morphology	CFH MFSD2A RTBDN CFHR4	2.18e-03	215	36	4	MP:0003728
MousePheno	abnormal forelimb zeugopod morphology	PAPPA2 FBN1 FBN2	2.26e-03	102	36	3	MP:0003855
MousePheno	impaired muscle relaxation	CFH CFHR4	2.34e-03	28	36	2	MP:0003157
MousePheno	dilated aorta	FBN1 TIMP1	2.34e-03	28	36	2	MP:0010574
MousePheno	increased mesangial cell number	CFH CFHR4	2.51e-03	29	36	2	MP:0011427
MousePheno	abnormal thrombosis	CFH FBN1 CFHR4	2.52e-03	106	36	3	MP:0005048
MousePheno	abnormal electroretinogram waveform feature	CFH RTBDN CFHR4	2.52e-03	106	36	3	MP:0012029
Domain	Sushi	CFH PAPPA2 APOH CR2 F13B CFHR4	2.59e-09	52	45	6	PF00084
Domain	CCP	CFH PAPPA2 APOH CR2 F13B CFHR4	3.28e-09	54	45	6	SM00032
Domain	SUSHI	CFH PAPPA2 APOH CR2 F13B CFHR4	4.10e-09	56	45	6	PS50923
Domain	Sushi_SCR_CCP_dom	CFH PAPPA2 APOH CR2 F13B CFHR4	4.58e-09	57	45	6	IPR000436
Domain	ConA-like_dom	PAPPA2 MALRD1 HERC1 BTN1A1 MID1 RNF135	1.35e-05	219	45	6	IPR013320
Domain	FBN	FBN1 FBN2	1.70e-05	3	45	2	IPR011398
Domain	SPRY	HERC1 BTN1A1 MID1 RNF135	5.66e-05	87	45	4	SM00449
Domain	SPRY	HERC1 BTN1A1 MID1 RNF135	7.65e-05	94	45	4	PF00622
Domain	SPRY_dom	HERC1 BTN1A1 MID1 RNF135	7.65e-05	94	45	4	IPR003877
Domain	B30.2/SPRY	HERC1 BTN1A1 MID1 RNF135	7.98e-05	95	45	4	IPR001870
Domain	B302_SPRY	HERC1 BTN1A1 MID1 RNF135	7.98e-05	95	45	4	PS50188
Domain	TB	FBN1 FBN2	1.18e-04	7	45	2	PF00683
Domain	-	FBN1 FBN2	1.57e-04	8	45	2	3.90.290.10
Domain	TB	FBN1 FBN2	2.02e-04	9	45	2	PS51364
Domain	TB_dom	FBN1 FBN2	2.02e-04	9	45	2	IPR017878
Domain	PRY	BTN1A1 MID1 RNF135	2.10e-04	48	45	3	SM00589
Domain	PRY	BTN1A1 MID1 RNF135	2.10e-04	48	45	3	IPR006574
Domain	Butyrophylin	BTN1A1 MID1 RNF135	6.39e-04	70	45	3	IPR003879
Domain	cEGF	FBN1 FBN2	1.78e-03	26	45	2	IPR026823
Domain	cEGF	FBN1 FBN2	1.78e-03	26	45	2	PF12662
Domain	PRY	BTN1A1 MID1	4.60e-03	42	45	2	PF13765
Domain	ZF_RING_1	RNF223 RNF181 MID1 RNF135	5.21e-03	291	45	4	PS00518
Domain	ZF_RING_2	RNF223 RNF181 MID1 RNF135	5.66e-03	298	45	4	PS50089
Domain	RING	RNF223 RNF181 MID1 RNF135	6.14e-03	305	45	4	SM00184
Domain	zf-RING_2	RNF223 RNF181	6.97e-03	52	45	2	PF13639
Domain	Znf_RING_CS	RNF223 MID1 RNF135	7.08e-03	163	45	3	IPR017907
Domain	Znf_RING	RNF223 RNF181 MID1 RNF135	7.73e-03	326	45	4	IPR001841
Domain	FN3	PAPPA2 EBI3 MID1	1.00e-02	185	45	3	SM00060
Pathway	KEGG_MEDICUS_REFERENCE_REGULATION_OF_COMPLEMENT_CASCADE_CFHR	CFH CFHR4	8.93e-05	6	35	2	M47880
Pathway	REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX	FBN1 FBN2 TIMP1 SPOCK3	1.75e-04	114	35	4	MM14571
Pathway	REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX	FBN1 FBN2 TIMP1 SPOCK3	3.84e-04	140	35	4	M587
Pathway	WP_COMPLEMENT_AND_COAGULATION_CASCADES	CFH CR2 F13B	3.94e-04	58	35	3	M39649
Pathway	WP_DENGUE2_INTERACTIONS_WITH_COMPLEMENT_AND_COAGULATION_CASCADES	CFH CR2 F13B	4.14e-04	59	35	3	M48343
Pathway	KEGG_COMPLEMENT_AND_COAGULATION_CASCADES	CFH CR2 F13B	6.57e-04	69	35	3	M16894
Pathway	REACTOME_COMPLEMENT_CASCADE	CFH CR2 CFHR4	1.16e-03	84	35	3	MM14653
Pubmed	Targeted inhibition of the complement alternative pathway with complement receptor 2 and factor H attenuates collagen antibody-induced arthritis in mice.	CFH CR2 CFHR4	2.17e-09	3	46	3	19828624
Pubmed	Molecular cloning of rat and mouse membrane cofactor protein (MCP, CD46): preferential expression in testis and close linkage between the mouse Mcp and Cr2 genes on distal chromosome 1.	CFH CR2 CFHR4	2.16e-08	5	46	3	9799332
Pubmed	Targeted complement inhibitors protect against posttransplant cardiac ischemia and reperfusion injury and reveal an important role for the alternative pathway of complement activation.	CFH CR2 CFHR4	2.16e-08	5	46	3	20962256
Pubmed	Molecular cloning of the b subunit of mouse coagulation factor XIII and assignment of the gene to chromosome 1: close evolutionary relationship to complement factor H.	CFH F13B CFHR4	2.16e-08	5	46	3	8468048
Pubmed	The NEI/NCBI dbGAP database: genotypes and haplotypes that may specifically predispose to risk of neovascular age-related macular degeneration.	CFH F13B CFHR4	4.32e-08	6	46	3	18541031
Pubmed	Genetic organization of complement receptor-related genes in the mouse.	CFH CR2 CFHR4	1.21e-07	8	46	3	2564419
Pubmed	Enhanced analysis of the mouse plasma proteome using cysteine-containing tryptic glycopeptides.	CFH APOH F13B CFHR4	1.16e-06	59	46	4	17330941
Pubmed	Homo- and heterotypic fibrillin-1 and -2 interactions constitute the basis for the assembly of microfibrils.	FBN1 FBN2	1.71e-06	2	46	2	12399449
Pubmed	Complement Factor H Modulates Splenic B Cell Development and Limits Autoantibody Production.	CFH CFHR4	1.71e-06	2	46	2	31354740
Pubmed	Local complement factor H protects kidney endothelial cell structure and function.	CFH CFHR4	1.71e-06	2	46	2	34139209
Pubmed	Systemic administration of Abeta mAb reduces retinal deposition of Abeta and activated complement C3 in age-related macular degeneration mouse model.	CFH CFHR4	1.71e-06	2	46	2	23799019
Pubmed	Fibrillin-1 and fibrillin-2 are essential for formation of thick oxytalan fibers in human nonpigmented ciliary epithelial cells in vitro.	FBN1 FBN2	1.71e-06	2	46	2	21851253
Pubmed	Circulating FH Protects Kidneys From Tubular Injury During Systemic Hemolysis.	CFH CFHR4	1.71e-06	2	46	2	32849636
Pubmed	Complement factor h is critical in the maintenance of retinal perfusion.	CFH CFHR4	1.71e-06	2	46	2	19541934
Pubmed	Complement factor H deficiency in aged mice causes retinal abnormalities and visual dysfunction.	CFH CFHR4	1.71e-06	2	46	2	17921253
Pubmed	The role of complement dysregulation in AMD mouse models.	CFH CFHR4	1.71e-06	2	46	2	24664701
Pubmed	Fibrillins can co-assemble in fibrils, but fibrillin fibril composition displays cell-specific differences.	FBN1 FBN2	1.71e-06	2	46	2	12429739
Pubmed	Mitochondrial decline precedes phenotype development in the complement factor H mouse model of retinal degeneration but can be corrected by near infrared light.	CFH CFHR4	1.71e-06	2	46	2	26149919
Pubmed	Absence of complement factor H reduces physical performance in C57BL6 mice.	CFH CFHR4	1.71e-06	2	46	2	32962822
Pubmed	Murine protein H is comprised of 20 repeating units, 61 amino acids in length.	CFH CFHR4	1.71e-06	2	46	2	2940596
Pubmed	Rare variants in FBN1 and FBN2 are associated with severe adolescent idiopathic scoliosis.	FBN1 FBN2	1.71e-06	2	46	2	24833718
Pubmed	A receptor for the complement regulator factor H increases transmission of trypanosomes to tsetse flies.	CFH CFHR4	1.71e-06	2	46	2	32165615
Pubmed	New Evidence Supporting the Role of FBN1 in the Development of Adolescent Idiopathic Scoliosis.	FBN1 FBN2	1.71e-06	2	46	2	30044367
Pubmed	Material and mechanical properties of bones deficient for fibrillin-1 or fibrillin-2 microfibrils.	FBN1 FBN2	1.71e-06	2	46	2	21440062
Pubmed	Transgenic mice expressing variants of complement factor H develop AMD-like retinal findings.	CFH CFHR4	1.71e-06	2	46	2	20538999
Pubmed	MAGP-2 has multiple binding regions on fibrillins and has covalent periodic association with fibrillin-containing microfibrils.	FBN1 FBN2	1.71e-06	2	46	2	15131124
Pubmed	Inheritance, hormonal regulation and properties of polymorphic murine antigens Mud1 and Mud2.	CFH CFHR4	1.71e-06	2	46	2	4992636
Pubmed	Retinal changes precede visual dysfunction in the complement factor H knockout mouse.	CFH CFHR4	1.71e-06	2	46	2	23844226
Pubmed	Death by color: differential cone loss in the aging mouse retina.	CFH CFHR4	1.71e-06	2	46	2	24929970
Pubmed	Cfh genotype interacts with dietary glycemic index to modulate age-related macular degeneration-like features in mice.	CFH CFHR4	1.71e-06	2	46	2	24370827
Pubmed	Prediction from sequence comparisons of residues of factor H involved in the interaction with complement component C3b.	CFH CFHR4	1.71e-06	2	46	2	8615824
Pubmed	Cadmium Induces Glomerular Endothelial Cell-Specific Expression of Complement Factor H via the -1635 AP-1 Binding Site.	CFH CFHR4	1.71e-06	2	46	2	30642982
Pubmed	Essential role of surface-bound complement factor H in controlling immune complex-induced arthritis.	CFH CFHR4	1.71e-06	2	46	2	23436934
Pubmed	Partial Complement Factor H Deficiency Associates with C3 Glomerulopathy and Thrombotic Microangiopathy.	CFH CFHR4	1.71e-06	2	46	2	26374608
Pubmed	Treatment with 670 nm light up regulates cytochrome C oxidase expression and reduces inflammation in an age-related macular degeneration model.	CFH CFHR4	1.71e-06	2	46	2	23469078
Pubmed	A gene locus concerned with an antigenic serum substance in Mus musculus.	CFH CFHR4	1.71e-06	2	46	2	4955525
Pubmed	Analysis of complement factor H mRNA expression: dexamethasone and IFN-gamma increase the level of H in L cells.	CFH CFHR4	1.71e-06	2	46	2	2533512
Pubmed	Complement factor H: spatial and temporal expression and localization in the eye.	CFH CFHR4	1.71e-06	2	46	2	16936129
Pubmed	Topical cyclodextrin reduces amyloid beta and inflammation improving retinal function in ageing mice.	CFH CFHR4	1.71e-06	2	46	2	25921262
Pubmed	Complement factor h limits immune complex deposition and prevents inflammation and scarring in glomeruli of mice with chronic serum sickness.	CFH CFHR4	1.71e-06	2	46	2	15574507
Pubmed	Nonselective assembly of fibrillin 1 and fibrillin 2 in the rodent ocular zonule and in cultured cells: implications for Marfan syndrome.	FBN1 FBN2	1.71e-06	2	46	2	24265020
Pubmed	Watching synchronous mitochondrial respiration in the retina and its instability in a mouse model of macular degeneration.	CFH CFHR4	1.71e-06	2	46	2	33558624
Pubmed	Genome-Wide Association Study Reveals Variants in CFH and CFHR4 Associated with Systemic Complement Activation: Implications in Age-Related Macular Degeneration.	CFH CFHR4	1.71e-06	2	46	2	29398083
Pubmed	Fibrillin-1 and fibrillin-2 in human embryonic and early fetal development.	FBN1 FBN2	1.71e-06	2	46	2	12524050
Pubmed	In vivo studies of mutant fibrillin-1 microfibrils.	FBN1 FBN2	1.71e-06	2	46	2	20529844
Pubmed	Complement factor H Y402H polymorphism results in diminishing CD4+ T cells and increasing C-reactive protein in plasma.	CFH CFHR4	1.71e-06	2	46	2	37940659
Pubmed	Immunohistochemical expression of fibrillin-1 and fibrillin-2 during tooth development.	FBN1 FBN2	1.71e-06	2	46	2	25524144
Pubmed	Comparative analysis of the properties and ligand binding characteristics of CspZ, a factor H binding protein, derived from Borrelia burgdorferi isolates of human origin.	CFH CFHR4	1.71e-06	2	46	2	19620346
Pubmed	Microfibril structure masks fibrillin-2 in postnatal tissues.	FBN1 FBN2	1.71e-06	2	46	2	20404337
Pubmed	Complement factor H regulates retinal development and its absence may establish a footprint for age related macular degeneration.	CFH CFHR4	1.71e-06	2	46	2	30705315
Pubmed	Design and evaluation of meningococcal vaccines through structure-based modification of host and pathogen molecules.	CFH CFHR4	1.71e-06	2	46	2	23133374
Pubmed	Human complement factor H Y402H polymorphism causes an age-related macular degeneration phenotype and lipoprotein dysregulation in mice.	CFH CFHR4	1.71e-06	2	46	2	30808757
Pubmed	Binding of factor H to tubular epithelial cells limits interstitial complement activation in ischemic injury.	CFH CFHR4	1.71e-06	2	46	2	21544060
Pubmed	A complement factor H homolog, heparan sulfation, and syndecan maintain inversin compartment boundaries in C. elegans cilia.	CFH CFHR4	1.71e-06	2	46	2	33859044
Pubmed	Fibrillin-1 mutations causing Weill-Marchesani syndrome and acromicric and geleophysic dysplasias disrupt heparan sulfate interactions.	FBN1 FBN2	1.71e-06	2	46	2	23133647
Pubmed	Fibrillln mutations in Marfan syndrome and related phenotypes.	FBN1 FBN2	1.71e-06	2	46	2	8791520
Pubmed	Regulation of age-related macular degeneration-like pathology by complement factor H.	CFH CFHR4	1.71e-06	2	46	2	25991857
Pubmed	Role of ocular complement factor H in a murine model of choroidal neovascularization.	CFH CFHR4	1.71e-06	2	46	2	20813971
Pubmed	Elevated ambulatory systolic-diastolic pressure regression index is genetically determined in hypertensive patients with coronary heart disease.	ADAMTS7 LPAR1	1.71e-06	2	46	2	28092973
Pubmed	Location of the mouse complement factor H gene (cfh) by FISH analysis and replication R-banding.	CFH CFHR4	1.71e-06	2	46	2	1486806
Pubmed	A chimeric Cfh transgene leads to increased retinal oxidative stress, inflammation, and accumulation of activated subretinal microglia in mice.	CFH CFHR4	1.71e-06	2	46	2	26030099
Pubmed	Spontaneous hemolytic uremic syndrome triggered by complement factor H lacking surface recognition domains.	CFH CFHR4	1.71e-06	2	46	2	17517971
Pubmed	Structure and expression of fibrillin-2, a novel microfibrillar component preferentially located in elastic matrices.	FBN1 FBN2	1.71e-06	2	46	2	8120105
Pubmed	The fibrillinopathies: New insights with focus on the paradigm of opposing phenotypes for both FBN1 and FBN2.	FBN1 FBN2	1.71e-06	2	46	2	35419902
Pubmed	Treatment with human complement factor H rapidly reverses renal complement deposition in factor H-deficient mice.	CFH CFHR4	1.71e-06	2	46	2	20445496
Pubmed	Possible role of complement factor H in podocytes in clearing glomerular subendothelial immune complex deposits.	CFH CFHR4	1.71e-06	2	46	2	31133737
Pubmed	Fibrillin genes map to regions of conserved mouse/human synteny on mouse chromosomes 2 and 18.	FBN1 FBN2	1.71e-06	2	46	2	8307578
Pubmed	Fibrillins 1 and 2 perform partially overlapping functions during aortic development.	FBN1 FBN2	1.71e-06	2	46	2	16407178
Pubmed	High-density lipoproteins are a potential therapeutic target for age-related macular degeneration.	CFH CFHR4	1.71e-06	2	46	2	32737203
Pubmed	Fibrillin assembly: dimer formation mediated by amino-terminal sequences.	FBN1 FBN2	1.71e-06	2	46	2	10504303
Pubmed	Genetic variation in CFH predicts phenytoin-induced maculopapular exanthema in European-descent patients.	CFH CFHR4	1.71e-06	2	46	2	29288229
Pubmed	Linkage of Marfan syndrome and a phenotypically related disorder to two different fibrillin genes.	FBN1 FBN2	1.71e-06	2	46	2	1852206
Pubmed	Tumour extracellular vesicle-derived Complement Factor H promotes tumorigenesis and metastasis by inhibiting complement-dependent cytotoxicity of tumour cells.	CFH CFHR4	1.71e-06	2	46	2	33708358
Pubmed	Serological survey of complement factor H in common laboratory and wild mice: a new third allotype.	CFH CFHR4	1.71e-06	2	46	2	2522412
Pubmed	Absence of complement factor H alters bone architecture and dynamics.	CFH CFHR4	1.71e-06	2	46	2	30107932
Pubmed	Murine Factor H Co-Produced in Yeast With Protein Disulfide Isomerase Ameliorated C3 Dysregulation in Factor H-Deficient Mice.	CFH CFHR4	1.71e-06	2	46	2	34054871
Pubmed	N-terminal domains of fibrillin 1 and fibrillin 2 direct the formation of homodimers: a possible first step in microfibril assembly.	FBN1 FBN2	1.71e-06	2	46	2	10359653
Pubmed	Distinct and separable roles of the complement system in factor H-deficient bone marrow chimeric mice with immune complex disease.	CFH CFHR4	1.71e-06	2	46	2	16597679
Pubmed	Developmental expression of fibrillin genes suggests heterogeneity of extracellular microfibrils.	FBN1 FBN2	1.71e-06	2	46	2	7744963
Pubmed	Factor H binding to PspC of Streptococcus pneumoniae increases adherence to human cell lines in vitro and enhances invasion of mouse lungs in vivo.	CFH CFHR4	1.71e-06	2	46	2	17562771
Pubmed	AAV Gene Augmentation of Truncated Complement Factor H Differentially Rescues Ocular Complement Dysregulation in a Mouse Model.	CFH CFHR4	1.71e-06	2	46	2	37471073
Pubmed	Aged complement factor H knockout mice kept in a clean barriered environment have reduced retinal pathology.	CFH CFHR4	1.71e-06	2	46	2	27397653
Pubmed	Complement Factor H Serum Levels Determine Resistance to Pneumococcal Invasive Disease.	CFH CFHR4	1.71e-06	2	46	2	26802141
Pubmed	Effect of Anti-C5a Therapy in a Murine Model of Early/Intermediate Dry Age-Related Macular Degeneration.	CFH CFHR4	1.71e-06	2	46	2	29392311
Pubmed	The critical role of complement alternative pathway regulator factor H in allergen-induced airway hyperresponsiveness and inflammation.	CFH CFHR4	1.71e-06	2	46	2	22174452
Pubmed	Fibrillin microfibrils in bone physiology.	FBN1 FBN2	1.71e-06	2	46	2	26408953
Pubmed	Expression of human complement factor H prevents age-related macular degeneration-like retina damage and kidney abnormalities in aged Cfh knockout mice.	CFH CFHR4	1.71e-06	2	46	2	25447048
Pubmed	Structure of the murine complement factor H gene.	CFH CFHR4	1.71e-06	2	46	2	2972715
Pubmed	Loss of Complement Factor H in Plasma Increases Endothelial Cell Migration.	CFH CFHR4	1.71e-06	2	46	2	28819420
Pubmed	Complement factor H genotypes impact risk of age-related macular degeneration by interaction with oxidized phospholipids.	CFH CFHR4	1.71e-06	2	46	2	22875704
Pubmed	Complement factor H deficiency combined with smoking promotes retinal degeneration in a novel mouse model.	CFH CFHR4	1.71e-06	2	46	2	34775843
Pubmed	Arg-Gly-Asp-containing domains of fibrillins-1 and -2 distinctly regulate lung fibroblast migration.	FBN1 FBN2	1.71e-06	2	46	2	18006876
Pubmed	Proteome-wide characterization of N-glycosylation events by diagonal chromatography.	CFH APOH F13B CFHR4	3.38e-06	77	46	4	16944957
Pubmed	Genetic contributions of nonautoimmune SWR mice toward lupus nephritis.	CFH CR2 CFHR4	4.30e-06	24	46	3	11739537
Pubmed	Human complement factor H-related protein 4 binds and recruits native pentameric C-reactive protein to necrotic cells.	CFH CFHR4	5.13e-06	3	46	2	19084272
Pubmed	Complement factor H deficiency accelerates development of lupus nephritis.	CFH CFHR4	5.13e-06	3	46	2	21148254
Pubmed	Complement factor H protects mice from ischemic acute kidney injury but is not critical for controlling complement activation by glomerular IgM.	CFH CFHR4	5.13e-06	3	46	2	29389016
Pubmed	Interaction of tropoelastin with the amino-terminal domains of fibrillin-1 and fibrillin-2 suggests a role for the fibrillins in elastic fiber assembly.	FBN1 FBN2	5.13e-06	3	46	2	10825173
Pubmed	Prevention of Fatal C3 Glomerulopathy by Recombinant Complement Receptor of the Ig Superfamily.	CFH CFHR4	5.13e-06	3	46	2	29895552
Pubmed	Structural polymorphism of murine complement factor H controlled by a locus located between the Hc and the beta 2M locus on the second chromosome of the mouse.	CFH CFHR4	5.13e-06	3	46	2	3156187
Cytoband	1q32	CFH CR2 CFHR4	1.68e-05	49	46	3	1q32
Cytoband	Ensembl 112 genes in cytogenetic band chr1q31	CFH F13B CFHR4	6.04e-05	75	46	3	chr1q31
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	CFH PAPPA2 APOH CR2 F13B CFHR4	5.19e-10	57	31	6	1179
GeneFamily	Complement system\|Sushi domain containing	CFH CR2 CFHR4	3.14e-05	36	31	3	492
GeneFamily	Ring finger proteins	RNF223 RNF181 MID1 RNF135	1.19e-03	275	31	4	58
Coexpression	GSE41978_ID2_KO_VS_ID2_KO_AND_BIM_KO_KLRG1_LOW_EFFECTOR_CD8_TCELL_UP	RIOK3 PAX4 RTBDN TIMP1 MID1	2.62e-05	200	46	5	M9555
Coexpression	CLASPER_LYMPHATIC_VESSELS_DURING_METASTASIS_DN	FBN1 TIMP1 LPAR1	3.18e-05	35	46	3	M11788
Coexpression	CLASPER_LYMPHATIC_VESSELS_DURING_METASTASIS_DN	FBN1 TIMP1 LPAR1	3.47e-05	36	46	3	MM1212
Coexpression	NABA_MATRISOME	PAPPA2 FBN1 FBN2 TIMP1 EBI3 ADAMTS7 MUC5AC SPOCK3 F13B	5.43e-05	1008	46	9	MM17056
Coexpression	NABA_MATRISOME	PAPPA2 FBN1 FBN2 TIMP1 EBI3 ADAMTS7 MUC5AC SPOCK3 F13B	6.22e-05	1026	46	9	M5889
Coexpression	CASTELLANO_HRAS_AND_NRAS_TARGETS_UP	CFH CFHR4	8.38e-05	8	46	2	MM1086
Coexpression	KRAS.PROSTATE_UP.V1_UP	CFH APOH CR2 MYO7B	9.83e-05	137	46	4	M2902
Coexpression	HALLMARK_COAGULATION	CFH FBN1 TIMP1 F13B	1.01e-04	138	46	4	M5946
CoexpressionAtlas	dev gonad_e13.5_F_VascAssocMesenchStromOvary_MafB_k-means-cluster#2_top-relative-expression-ranked_1000	CFH PAPPA2 FBN1 FBN2 TIMP1 LPAR1	1.69e-05	265	44	6	gudmap_dev gonad_e13.5_F_VascAssocMesenchStromOvary_MafB_k2_1000
ToppCell	10x_3'_v3-blood_(10x_3'_v3)-myeloid-myeloid_dendritic\|blood_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	CFH LRCOL1 MALRD1 MUC5AC SPOCK3	6.92e-07	162	46	5	233011408f022647932c81ebab78f9813e3c6833
ToppCell	343B-Fibroblasts-Fibroblast-A_(Fibroblast_progenitors)-\|343B / Donor, Lineage, Cell class and subclass (all cells)	CFH FBN1 TCERG1L TIMP1 LPAR1	1.04e-06	176	46	5	2e94bbe17c0bb65dc58b4ebc0cb829258bd7373b
ToppCell	343B-Fibroblasts-Fibroblast-A_(Fibroblast_progenitors)\|343B / Donor, Lineage, Cell class and subclass (all cells)	CFH FBN1 TCERG1L TIMP1 LPAR1	1.04e-06	176	46	5	f33ab41d121b59d871ad7d48ca021524a027d2ef
ToppCell	facs-Lung-EPCAM-24m-Mesenchymal-adventitial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFH FBN1 TIMP1 ADAMTS7 LPAR1	1.26e-06	183	46	5	7e5c467fd1b156b928f1611a12ab4affb9f714b7
ToppCell	facs-Lung-EPCAM-24m-Mesenchymal-Adventitial_Fibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFH FBN1 TIMP1 ADAMTS7 LPAR1	1.26e-06	183	46	5	63294d66e3ccf152ffe5d1237106764c14390b62
ToppCell	droplet-Kidney-KIDNEY-1m-Mesenchymal-fibroblast\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFH FBN1 FBN2 TIMP1 LPAR1	1.37e-06	186	46	5	94d577dbb6bfacf50632e1fe8af041b35a1e6b23
ToppCell	droplet-Trachea-3m-Mesenchymal-myofibroblast\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CFH PAPPA2 FBN1 TIMP1 LPAR1	1.72e-06	195	46	5	0feb6ebe7b4b781dec7cfaef844140cfbf84b4b9
ToppCell	droplet-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CFH PAPPA2 FBN1 TIMP1 LPAR1	1.72e-06	195	46	5	2a6f67875cef140b0e6b8401436719675c6b3665
ToppCell	RA-02._Fibroblast_II\|World / Chamber and Cluster_Paper	CFH FBN1 TIMP1 LPAR1 MID1	1.77e-06	196	46	5	e8cbda03837f1f26470a9d93aa7fdaa04e08e38a
ToppCell	Striatum-Macroglia-CSF_related-EPENDYMAL-Ependyma_Ccdc153.Ccdc153_(Ccdc153)-\|Striatum / BrainAtlas - Mouse McCarroll V32	ECT2L DNAH12 MYO7B NAGS	6.51e-06	117	46	4	26dec09112532f351fb7a2202bae84c365707b40
ToppCell	Striatum-Macroglia-CSF_related-EPENDYMAL-Ependyma_Ccdc153.Ccdc153_(Ccdc153)\|Striatum / BrainAtlas - Mouse McCarroll V32	ECT2L DNAH12 MYO7B NAGS	6.51e-06	117	46	4	db053c874e6739052dff1f91643e51b306236237
ToppCell	Striatum-Macroglia-CSF_related-EPENDYMAL-Ependyma_Ccdc153.Ccdc153_(Ccdc153)--\|Striatum / BrainAtlas - Mouse McCarroll V32	ECT2L DNAH12 MYO7B NAGS	6.51e-06	117	46	4	80780223502d18f0d86a29ff3cb74aa8235103c7
ToppCell	Hippocampus-Macroglia-CSF_related-EPENDYMAL-Ependymal.Ccdc153_(Ccdc153)--\|Hippocampus / BrainAtlas - Mouse McCarroll V32	ECT2L LRCOL1 DNAH12 MYO7B	6.51e-06	117	46	4	454efceabe739cdf293f81c8a938811f12321a47
ToppCell	Striatum-Macroglia-CSF_related-EPENDYMAL\|Striatum / BrainAtlas - Mouse McCarroll V32	ECT2L DNAH12 MYO7B NAGS	6.51e-06	117	46	4	40889f4a387846abbf54469cc4faf616bfe348d0
ToppCell	Hippocampus-Macroglia-CSF_related-EPENDYMAL-Ependymal.Ccdc153_(Ccdc153)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	ECT2L LRCOL1 DNAH12 MYO7B	6.51e-06	117	46	4	91936a3ffbfa29024ced9d01df962b4ccfaf8966
ToppCell	Striatum-Macroglia-CSF_related\|Striatum / BrainAtlas - Mouse McCarroll V32	ECT2L DNAH12 MYO7B NAGS	6.51e-06	117	46	4	e12e37e393257db85f7f5c13454095c44f59d374
ToppCell	Hippocampus-Macroglia-CSF_related-EPENDYMAL\|Hippocampus / BrainAtlas - Mouse McCarroll V32	ECT2L LRCOL1 DNAH12 MYO7B	6.51e-06	117	46	4	409b3ab16786bced8c9bc9c0e89b0078402f365a
ToppCell	Hippocampus-Macroglia-CSF_related-EPENDYMAL-Ependymal.Ccdc153_(Ccdc153)-\|Hippocampus / BrainAtlas - Mouse McCarroll V32	ECT2L LRCOL1 DNAH12 MYO7B	6.51e-06	117	46	4	e33ec9044541d2ef53f6633891238559b01b7957
ToppCell	facs-Thymus-nan-3m-Epithelial-epithelial_cell_of_thymus\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PAX4 HTR5A ADAMTS7 F13B	1.32e-05	140	46	4	115bd770a9d5e6f007a9aa0eadf5dba46d500107
ToppCell	facs-Thymus-nan-3m-Epithelial\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PAX4 HTR5A ADAMTS7 F13B	1.32e-05	140	46	4	22d126e80bf7d9c0ca6ec686b5cc66fa584a1ab6
ToppCell	facs-Thymus-nan-3m-Epithelial-TECs\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PAX4 HTR5A ADAMTS7 F13B	1.32e-05	140	46	4	62d1ef8cb78618ed89cac7ec89d7f54de06a90c7
ToppCell	E16.5-samps-Mesenchymal-Matrix_fibroblast-_fetal-Mature_Fibroblast_1\|E16.5-samps / Age Group, Lineage, Cell class and subclass	CFH FBN1 LPAR1 VPS13C	2.41e-05	163	46	4	f1ec2625b52664308968b01d8e0275e1e0751480
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CFH FBN1 FBN2 CFHR4	2.77e-05	169	46	4	c0824a93674e2bff0f09b2d2fab5bab016a2e379
ToppCell	PND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CFH FBN1 TIMP1 LPAR1	2.77e-05	169	46	4	031465190cd3623a25ef2b868daab8d932c8ff08
ToppCell	356C-Epithelial_cells-Epithelial-G_(Club-Clara_cells)-\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	CFH FBN1 EBI3 MUC5AC	3.32e-05	177	46	4	709235694cc711b9b79690e23c94577b2ae06811
ToppCell	nucseq-Epithelial-Epithelial_Airway-Basal/Suprabasal-Basal\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CFH SPOCK3 UGT1A8 MID1	3.32e-05	177	46	4	ce86dfaeb74d995a19aea62f0fb15c4c0bb854b0
ToppCell	356C-Epithelial_cells-Epithelial-G_(Club-Clara_cells)\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	CFH FBN1 EBI3 MUC5AC	3.32e-05	177	46	4	7f9c2a45a994b32f15e5693f7cb873716a4eb568
ToppCell	nucseq-Epithelial-Epithelial_Airway-Basal/Suprabasal\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CFH SPOCK3 UGT1A8 MID1	3.32e-05	177	46	4	cbad1a23851151dbef01ea2af960e6f0944f838b
ToppCell	P28-Mesenchymal-mesenchymal_fibroblast-mesenchymal_alveolar_niche_cell\|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	CFH FBN1 TIMP1 LPAR1	3.55e-05	180	46	4	9adebde5f4ca6dcb90e9113622862e14298465ac
ToppCell	RA-01._Fibroblast_I\|World / Chamber and Cluster_Paper	CFH FBN1 TIMP1 LPAR1	3.62e-05	181	46	4	2b6ddeb53a79a658e2ba78527ff48c155b20daa6
ToppCell	PND14-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_mature\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CFH FBN1 TIMP1 LPAR1	3.62e-05	181	46	4	6730e249cac55ae892cc567d9211615882f3dab4
ToppCell	PND14-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CFH FBN1 TIMP1 LPAR1	3.62e-05	181	46	4	3462aa1c08fbaf613b6278ab2c7a5a0940bf537d
ToppCell	P15-Mesenchymal-mesenchymal_fibroblast-mesenchymal_alveolar_niche_cell\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	CFH FBN1 TIMP1 LPAR1	3.70e-05	182	46	4	e9fcae9d03a6faf85b91882c5da699037bc61aeb
ToppCell	Control-Epithelial-Basal\|Control / Disease state, Lineage and Cell class	CFH SPOCK3 UGT1A8 MID1	3.70e-05	182	46	4	caddd0a52f0234ea6a916186ffaf2454cdcd80ee
ToppCell	facs-Large_Intestine-Proximal-24m-Epithelial-enteroendocrine_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PAPPA2 LRCOL1 PAX4 RTBDN	3.95e-05	185	46	4	2a8104f610fa5ce618f8105521616722462a0d42
ToppCell	PND07-28-samps-Mesenchymal-Myofibroblast-myofibroblast_-_mature_-_C\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	PAPPA2 FBN1 FBN2 LPAR1	3.95e-05	185	46	4	427176ad9ab8d9511200fb0a132cfd1e835fe35c
ToppCell	droplet-Kidney-KIDNEY-1m-Mesenchymal-Stroma____fibroblast\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBN1 FBN2 TIMP1 LPAR1	3.95e-05	185	46	4	785c55d39909fac74415f24427979691e7e694e6
ToppCell	droplet-Kidney-KIDNEY-1m-Mesenchymal\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBN1 FBN2 TIMP1 LPAR1	3.95e-05	185	46	4	97a1dcacbc48dc3f41c26fbb59af35c935f894d4
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_Arw_fibro_(16)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	CFH PAPPA2 FBN1 FBN2	4.11e-05	187	46	4	5258674d0346e5c51a4b965efcdc1790c970845d
ToppCell	facs-Heart-LA-24m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFH FBN1 TIMP1 LPAR1	4.11e-05	187	46	4	1669df899b1759c338ffce196fe009840123cfcd
ToppCell	facs-Heart-LA-24m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFH FBN1 TIMP1 LPAR1	4.11e-05	187	46	4	f3ef3f5a761f8306edc39bf16e76e44aae6fa7f6
ToppCell	kidney_cells-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CFH FBN1 TIMP1 LPAR1	4.20e-05	188	46	4	c32d023a69b6da79687ff8fa7485e7499db57046
ToppCell	kidney_cells-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CFH FBN1 TIMP1 LPAR1	4.20e-05	188	46	4	1cd5a4d744bd3777246958ea5eb94388a5cbad81
ToppCell	droplet-Pancreas-PANCREAS-30m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFH FBN1 FBN2 TIMP1	4.29e-05	189	46	4	1821ae4a6e37ee4c6308071883f3f447a7c53c53
ToppCell	droplet-Pancreas-PANCREAS-30m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFH FBN1 FBN2 TIMP1	4.29e-05	189	46	4	1e4d7e8dc98b3d70351e6a6c2aaf9ca01f141b8f
ToppCell	droplet-Lung-LUNG-30m-Mesenchymal-adventitial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFH FBN1 TIMP1 LPAR1	4.29e-05	189	46	4	6b3b42d758b63a0df62310c34fa3bde421c1afd7
ToppCell	droplet-Pancreas-PANCREAS-30m-Mesenchymal\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFH FBN1 FBN2 TIMP1	4.29e-05	189	46	4	1dc415ed41815f4296dafd8cf7f3e014c44db1db
ToppCell	droplet-Lung-LUNG-30m-Mesenchymal-Adventitial_Fibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFH FBN1 TIMP1 LPAR1	4.29e-05	189	46	4	344b23d3c47d0665dda1cd4856a5e72f1c28cfb3
ToppCell	(2)_Fibroblasts-(22)_Fibro-3\|World / Cell class and subclass of bone marrow stroma cells in homeostatis	FBN2 TIMP1 SPOCK3 LPAR1	4.38e-05	190	46	4	3aed03b87ba2c8d479048c3ceef3ff5e38746c28
ToppCell	droplet-Lung-nan-18m-Mesenchymal-Adventitial_Fibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFH FBN1 TIMP1 LPAR1	4.38e-05	190	46	4	97772e69e6f51ebffbb5433ca7b40f1048723220
ToppCell	Fetal_29-31_weeks-Mesenchymal-matrix_fibroblast_2_cell-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CFH FBN1 TIMP1 LPAR1	4.38e-05	190	46	4	0fea33f2dc1efa23aaa2da1c318482a52a313ff1
ToppCell	droplet-Lung-nan-18m-Mesenchymal-adventitial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFH FBN1 TIMP1 LPAR1	4.38e-05	190	46	4	72c2b824acdc43139e6635785df3ed3feb58ec46
ToppCell	droplet-Heart-HEART_(LV+RV_ONLY)-30m-Mesenchymal\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFH FBN1 TIMP1 LPAR1	4.47e-05	191	46	4	1efb47743b6834b64cb0f61721ddbe875b1a66ca
ToppCell	facs-Lung-18m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l1\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CFH FBN1 TIMP1 LPAR1	4.47e-05	191	46	4	2b73fcd592d16cae8ded5e45c8fbf2d9adc8caad
ToppCell	facs-Lung-3m-Mesenchymal-fibroblast\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CFH FBN1 TIMP1 LPAR1	4.47e-05	191	46	4	997abf0cc5873bed0372c4a333ed307fa72774d2
ToppCell	droplet-Kidney-nan-18m-Mesenchymal\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFH FBN1 TIMP1 LPAR1	4.56e-05	192	46	4	38d7a24ae205ef91ed2e0f402d8022f2a9cdb243
ToppCell	kidney_cells-Adult_normal_reference-Mesenchymal-Fibroblast-Degenerative_Fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CFH FBN1 TIMP1 LPAR1	4.56e-05	192	46	4	41a8326cd5bc19ad5041068501bab4c72399222e
ToppCell	Fetal_29-31_weeks-Mesenchymal-matrix_fibroblast_2_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CFH FBN1 LPAR1 MID1	4.56e-05	192	46	4	8d56e360ebc624ca4cd7f0af4f3cc599c244f134
ToppCell	droplet-Kidney-KIDNEY-30m-Mesenchymal-fibroblast\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFH FBN1 TIMP1 LPAR1	4.56e-05	192	46	4	853a930e0641ffb50cbb4cef5837c70d75c3fc39
ToppCell	droplet-Kidney-KIDNEY-30m-Mesenchymal-Stroma____fibroblast\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFH FBN1 TIMP1 LPAR1	4.56e-05	192	46	4	d2c03490c5e835d0f0a732803093c64b8d4b4029
ToppCell	droplet-Lung-18m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l49\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CFH FBN1 TIMP1 LPAR1	4.56e-05	192	46	4	1b228f0929b505de82a39bf64c837887b0e56701
ToppCell	COVID-19-Heart-Fib_+_EC_+_Pericyte\|Heart / Disease (COVID-19 only), tissue and cell type	CFH FBN1 TIMP1 LPAR1	4.56e-05	192	46	4	60b1312e84f6d6448365a952469c506c00b5fe93
ToppCell	facs-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CFH FBN1 TIMP1 LPAR1	4.56e-05	192	46	4	32acd89617934016cd135d2cc797e8e79ae1b37f
ToppCell	PND03-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FBN1 FBN2 TIMP1 LPAR1	4.56e-05	192	46	4	ad48c941a3ddfd9a5146bafc2209da577bb50531
ToppCell	droplet-Heart-HEART_(LV+RV_ONLY)-30m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFH FBN1 TIMP1 LPAR1	4.56e-05	192	46	4	5e6f8206ee0b10cdba79a7c4a05452cb025a5512
ToppCell	facs-Lung-nan-3m-Mesenchymal-Adventitial_Fibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFH FBN1 TIMP1 LPAR1	4.56e-05	192	46	4	a2c31390da4962bda9a936470b0b68fa1f5d47d1
ToppCell	droplet-Kidney-nan-18m-Mesenchymal-fibroblast\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFH FBN1 TIMP1 LPAR1	4.56e-05	192	46	4	84149a5c6c3b3c9b86aed77cf8e72d99ef099fab
ToppCell	kidney_cells-Adult_normal_reference-Mesenchymal-Fibroblast-Degenerative_Fibroblast-Degenerative_Fibroblast_119\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CFH FBN1 TIMP1 LPAR1	4.56e-05	192	46	4	f88aba74d6e8c594c32fe2bc095b5da28b4b28e9
ToppCell	PND28-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CFH FBN1 TIMP1 LPAR1	4.56e-05	192	46	4	cdc652dbfabe41b324fd85c1ed933d29fb73a49f
ToppCell	droplet-Lung-1m-Mesenchymal-fibroblast-adventitial_fibroblast\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CFH FBN1 TIMP1 LPAR1	4.56e-05	192	46	4	f9fb24457999dc9e751a099d7f995543b9330ad4
ToppCell	PND28-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_mature\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CFH FBN1 TIMP1 LPAR1	4.56e-05	192	46	4	29bee88b45e23f16543ffc7cc361bc5da5d16a2b
ToppCell	facs-Lung-18m-Mesenchymal-fibroblast-adventitial_fibroblast\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CFH FBN1 TIMP1 LPAR1	4.56e-05	192	46	4	011634a24b0c61d9b463fe755502edbc5cd70b7a
ToppCell	droplet-Kidney-nan-18m-Mesenchymal-Stroma____fibroblast\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFH FBN1 TIMP1 LPAR1	4.56e-05	192	46	4	04d155897ed075c359933080e36a4ab2150b6e9f
ToppCell	Mesenchymal-matrix_fibroblast_2_cell\|World / Lineage, Cell type, age group and donor	CFH FBN1 LPAR1 MID1	4.56e-05	192	46	4	a769158c49d2b208c4224d85e7ae68c85cc372ed
ToppCell	droplet-Kidney-KIDNEY-30m-Mesenchymal\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFH FBN1 TIMP1 LPAR1	4.56e-05	192	46	4	49281626ecad0456fdbded2378b7028d7b589686
ToppCell	facs-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l1\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CFH FBN1 TIMP1 LPAR1	4.56e-05	192	46	4	7b48df661f61ce494bf6f0b9a74b0422e29c24bf
ToppCell	facs-Lung-nan-3m-Mesenchymal-adventitial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFH FBN1 TIMP1 LPAR1	4.56e-05	192	46	4	eeab1cef7c36ae824381952c5b2c982368c379fd
ToppCell	LPS_only-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FBN1 TIMP1 LPAR1 MID1	4.56e-05	192	46	4	df1545670370fb1010c567cd059c2783eab315f7
ToppCell	droplet-Heart-HEART_(LV+RV_ONLY)-30m-Mesenchymal-fibroblast\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFH FBN1 TIMP1 LPAR1	4.56e-05	192	46	4	136af0186c70c14c5f2b33ed7a148156de5b478c
ToppCell	facs-Lung-24m-Mesenchymal-fibroblast-adventitial_fibroblast\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CFH FBN1 TIMP1 LPAR1	4.65e-05	193	46	4	e27885a9e1a2a3e165c5366d4cfcda05c5454483
ToppCell	PND28-Mesenchymal-Mesenchymal_structural\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CFH FBN1 TIMP1 LPAR1	4.65e-05	193	46	4	ec81c1afdae2e0433a22c8c1fa1c6232526ff7e7
ToppCell	facs-Lung-EPCAM-18m-Mesenchymal-adventitial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFH FBN1 TIMP1 LPAR1	4.65e-05	193	46	4	ac088c8f27b5b1888610e461ff45870ca60da886
ToppCell	droplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFH FBN1 TIMP1 LPAR1	4.65e-05	193	46	4	0a665531d581d4e3941e29d3f95569da8f166447
ToppCell	facs-Lung-EPCAM-18m-Mesenchymal-Adventitial_Fibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFH FBN1 TIMP1 LPAR1	4.65e-05	193	46	4	92048d2e9e43513e6185e09553be3ee47d7e5207
ToppCell	droplet-Lung-immune-endo-depleted-3m-Mesenchymal-adventitial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFH FBN1 TIMP1 LPAR1	4.65e-05	193	46	4	858a186804b36d45957238d3d3eed2768b961641
ToppCell	droplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Mesenchymal-fibroblast\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFH FBN1 TIMP1 LPAR1	4.65e-05	193	46	4	24ce1f37cca655415410d2403a52d1ebb3332280
ToppCell	PND28-Mesenchymal-Mesenchymal_structural-Fibroblastic\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CFH FBN1 TIMP1 LPAR1	4.65e-05	193	46	4	30481fb01c7acf85beae10213f038da86bed6777
ToppCell	facs-Lung-nan-3m-Mesenchymal\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFH FBN1 TIMP1 LPAR1	4.65e-05	193	46	4	d9c20a092b507c43fcf7ccb04073fecd27d1749c
ToppCell	droplet-Lung-immune-endo-depleted-3m-Mesenchymal-Adventitial_Fibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFH FBN1 TIMP1 LPAR1	4.65e-05	193	46	4	7865e7ec0a288249540d4cba94ae01c93e1b617c
ToppCell	droplet-Lung-18m-Mesenchymal-fibroblast-adventitial_fibroblast\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CFH FBN1 TIMP1 LPAR1	4.65e-05	193	46	4	fe9720185929ef849edd1b8eb4854306b392e5a2
ToppCell	ASK440-Epithelial-Secretory\|ASK440 / Donor, Lineage and Cell class of Lung cells from Dropseq	CFH MALRD1 SPOCK3 LPAR1	4.65e-05	193	46	4	50e98d91697c7af6a3de39e52edde6dd2b67b512
ToppCell	COVID-19-Heart-Fib_2\|Heart / Disease (COVID-19 only), tissue and cell type	CFH FBN1 TIMP1 LPAR1	4.75e-05	194	46	4	d91c9f2ec47319051fc398320693fddbe8bbd4d6
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Degenerative_Fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CFH FBN1 TIMP1 SPOCK3	4.75e-05	194	46	4	29f83cdd63314fff41258937d70b881a5503bfcc
ToppCell	Control-Fibroblasts-Intermediate_pathological_FB\|Control / group, cell type (main and fine annotations)	CFH FBN1 TIMP1 LPAR1	4.75e-05	194	46	4	03a269f75a481ea54aea8e6444605db8d6df493d
ToppCell	droplet-Lung-21m-Mesenchymal-fibroblast-adventitial_fibroblast\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CFH FBN1 TIMP1 LPAR1	4.75e-05	194	46	4	ca1f24070424b44b7a442e4fca761ebfbe24b063
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Degenerative_Fibroblast-Degenerative_Fibroblast_119\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CFH FBN1 TIMP1 SPOCK3	4.75e-05	194	46	4	d3db241ea316bbcde6d16618193b474591ad5ce4
ToppCell	LV-02._Fibroblast_II\|LV / Chamber and Cluster_Paper	CFH FBN1 TIMP1 LPAR1	4.75e-05	194	46	4	014d2feb5db2a6a35ef759761a41e466e108c3c1
ToppCell	facs-Lung-24m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l1\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CFH FBN1 TIMP1 LPAR1	4.75e-05	194	46	4	c9e589fe7df6a9b377654581a2aebb607cbb03b9
ToppCell	18-Distal-Mesenchymal-Mesenchyme_SERPINF1-high\|Distal / Age, Tissue, Lineage and Cell class	CFH FBN1 FBN2 TIMP1	4.84e-05	195	46	4	f86737bff21d81673238813df61a15cfe88d0b15
ToppCell	PND07-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF-SCMF_mature\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PAPPA2 FBN1 FBN2 LPAR1	4.84e-05	195	46	4	2514c1f23424b5fc664d326d31ffd22bafe74ef8
Computational	Neighborhood of TIMP2	PAPPA2 FBN2 EBI3	1.78e-04	46	26	3	GNF2_TIMP2
Computational	Neighborhood of KISS1	PAPPA2 FBN2 EBI3	2.15e-04	49	26	3	GNF2_KISS1
Disease	complement factor H-related protein 1 measurement	CFH DDX46 F13B CFHR4	1.64e-06	56	45	4	EFO_0600054
Disease	transmembrane protein 52 measurement	CFH APOH	2.27e-06	2	45	2	EFO_0803187
Disease	olfactomedin-4 measurement	CFH APOH	2.27e-06	2	45	2	EFO_0020617
Disease	c3d:C3 ratio	CFH CFHR4	2.27e-06	2	45	2	EFO_0008543
Disease	homeobox protein nanog measurement	CFH APOH	2.27e-06	2	45	2	EFO_0020456
Disease	angiopoietin-related protein 1 measurement	CFH APOH UGT1A8	2.66e-06	18	45	3	EFO_0801382
Disease	ephrin type-a receptor 3 measurement	CFH APOH	6.82e-06	3	45	2	EFO_0020352
Disease	calnexin measurement	CFH CFHR4	6.82e-06	3	45	2	EFO_0801444
Disease	mitochondrial fission regulator 1 measurement	CFH APOH	6.82e-06	3	45	2	EFO_0802749
Disease	C5a anaphylatoxin measurement	CFH APOH	6.82e-06	3	45	2	EFO_0020208
Disease	complement factor H-related protein 4A measurement	CFH CFHR4	6.82e-06	3	45	2	EFO_0600057
Disease	connective tissue disease (implicated_via_orthology)	FBN1 FBN2	6.82e-06	3	45	2	DOID:65 (implicated_via_orthology)
Disease	histone-lysine N-methyltransferase 2D measurement	CFH CFHR4	6.82e-06	3	45	2	EFO_0801683
Disease	descending aortic diameter	CFH PAPPA2 FBN1 ADAMTS7	1.00e-05	88	45	4	EFO_0021788
Disease	complement factor H-related protein 2 measurement	CFH F13B CFHR4	1.18e-05	29	45	3	EFO_0600055
Disease	NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial measurement	CFH CFHR4	1.36e-05	4	45	2	EFO_0803292
Disease	receptor tyrosine-protein kinase erbb-4 measurement	CFH APOH	1.36e-05	4	45	2	EFO_0020702
Disease	scoliosis (is_implicated_in)	FBN1 FBN2	1.36e-05	4	45	2	DOID:0060249 (is_implicated_in)
Disease	kallikrein-5 measurement	CFH CFHR4	1.36e-05	4	45	2	EFO_0020515
Disease	protein fam107a measurement	CFH APOH	2.27e-05	5	45	2	EFO_0020673
Disease	matrix extracellular phosphoglycoprotein measurement	CFH APOH	2.27e-05	5	45	2	EFO_0020557
Disease	complement C1s subcomponent measurement	CFH CFHR4	3.40e-05	6	45	2	EFO_0008091
Disease	complement factor H-related protein 5 measurement	CFH F13B CFHR4	3.65e-05	42	45	3	EFO_0008098
Disease	Atypical hemolytic-uremic syndrome	CFH CFHR4	8.13e-05	9	45	2	cv:C2931788
Disease	protein-tyrosine kinase 6 measurement	CFH UGT1A8	8.13e-05	9	45	2	EFO_0020691
Disease	Hemolytic-uremic syndrome	CFH CFHR4	8.13e-05	9	45	2	cv:C0019061
Disease	testis-specific chromodomain protein Y 1 measurement	CFH UGT1A8	8.13e-05	9	45	2	EFO_0802127
Disease	leukocyte immunoglobulin-like receptor subfamily A member 5 measurement	CFH CFHR4	8.13e-05	9	45	2	EFO_0801766
Disease	hemopexin measurement	CFH CFHR4	1.24e-04	11	45	2	EFO_0008149
Disease	retinol dehydrogenase 16 measurement	CFH UGT1A8	1.76e-04	13	45	2	EFO_0802007
Disease	sexual dimorphism measurement	PAPPA2 RIOK3 FBN1 HERC1 APOH LPAR1 BTN1A1 RNF135	2.38e-04	1106	45	8	EFO_0021796
Disease	glaucoma (is_marker_for)	CFH MUC5AC	4.25e-04	20	45	2	DOID:1686 (is_marker_for)
Disease	coagulation factor measurement	CFH CFHR4	4.25e-04	20	45	2	EFO_0004634
Disease	gastric ulcer (biomarker_via_orthology)	TIMP1 MUC5AC	4.69e-04	21	45	2	DOID:10808 (biomarker_via_orthology)
Disease	tissue factor measurement	CFH UGT1A8	4.69e-04	21	45	2	EFO_0010623
Disease	aortic measurement	CFH FBN1 ADAMTS7 LPAR1	5.79e-04	251	45	4	EFO_0020865
Disease	temperament and character inventory	FBN2 TCERG1L	6.14e-04	24	45	2	EFO_0004825
Disease	corneal topography	FBN1 ADAMTS7 LPAR1	6.21e-04	109	45	3	EFO_0004345
Disease	eye measurement	HERC1 SLC24A4	7.79e-04	27	45	2	EFO_0004731
Disease	Age related macular degeneration	CFH CFHR4	9.63e-04	30	45	2	C0242383
Disease	Complement deficiency disease	CFH CFHR4	1.17e-03	33	45	2	C0272242
Disease	ascending aortic diameter	FBN1 FBN2 LPAR1	1.28e-03	140	45	3	EFO_0021787
Disease	Growth Disorders	LPAR1 RNF135	1.39e-03	36	45	2	C0018273

Protein segments in the cluster

Peptide	Gene	Start	Entry
ICTLCKSNGWILPTV	AKR7A2	181	O43488
CPLTGLWPINTLKCT	APOH	66	P02749
LWPINTLKCTPRVCP	APOH	71	P02749
CLWSSGKKPLTICPI	BTN1A1	461	Q13410
PGWKLCPKCTQIING	ARL14EP	111	Q8N8R7
PPWVSGTCCSSVLKP	ECT2L	206	Q008S8
GRWQSIPLCVEKIPC	CFH	856	P08603
SCIPFLQSCLPKEWL	DESI2	136	Q9BSY9
EVTCSLPLCRWPLGT	ADAMTS7	986	Q9UKP4
WPLIFLLCVTIPNCS	SLC24A4	431	Q8NFF2
TLCTPKTIFLQCLPW	LRCOL1	61	A6NCL2
ELQGPTPLFCCWLVK	PASK	916	Q96RG2
FTSWQTCKPLLKCPS	NLRP8	336	Q86W28
APLVWKQLCCVPLTL	HERC1	4601	Q15751
WTPGLVLLLLDVCCP	LPAR1	271	Q92633
ITCNRGKWTLPPECV	F13B	376	P05160
PLVSSWLNSLKGPLC	DNAH12	1686	Q6ZR08
LQWCLESGSIPILCP	NAGS	246	Q8N159
SASLPPVCGEKCLWS	MUC5AC	1376	P98088
KPCWDCGSFLLPVIA	PAX4	301	O43316
PLVGLCISKSPWTCL	MFSD2A	111	Q8NA29
CISKSPWTCLGRLMP	MFSD2A	116	Q8NA29
PIISLTGPKCTLVFW	MALRD1	1166	Q5VYJ5
PAKLQGLSPWLTCLE	PAPPA2	1496	Q9BXP8
WSGPAPLCKLSLLAV	CR2	586	P20023
WKTLPGGNQCIVPIC	FBN1	71	P35555
LLALVLWASCPPCSG	EBI3	6	Q14213
LISPLCSCDIPAIWK	HTR5A	306	P47898
TQDGWLPTVPCLRTC	CFHR4	321	Q92496
WKTLPGGNQCIVPIC	FBN2	101	P35556
GCPKPIKSWVQCGIS	DDX46	366	Q7L014
TCGPTWLPLSEKRGC	RTBDN	131	Q9BSG5
WLPLSEKRGCEPSCL	RTBDN	136	Q9BSG5
PFLKCTLPWGTLSSL	RSBN1L	491	Q6PCB5
CIICQGLLDWPATLP	RNF135	21	Q8IUD6
SCILPWLSKTNSCPL	RNF181	101	Q9P0P0
LESCTLCVQPWPSLS	TMEM150B	206	A6NC51
KPWLQLCCPSTGLSC	STS	556	P08842
KPCLPASCLGETWSI	MRGPRG-AS1	91	Q2M3A8
WLEGTKLCCQPLPTT	RNF223	136	E7ERA6
KCPWAIPQNTISCSL	RIOK3	21	O14730
LSIPCKLQSGTHCLW	TIMP1	156	P01033
LCPSALATPIGKSWI	TCERG1L	141	Q5VWI1
WQKLIIPSGSCPVIL	SPIDR	366	Q14159
PVCPTFTVWNKCLTI	MID1	636	O15344
CLPFWPESLSGKLCV	VPS13C	2906	Q709C8
WRGPILSTCKQCPVV	SPOCK3	131	Q9BQ16
WTSPIPLCVSLLLTC	UGT1A8	6	Q9HAW9
WILLSLCLGCFPPSE	MYO7B	1131	Q6PIF6