Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	phosphatidylinositol 3-kinase regulatory subunit binding	PTPN13 PIK3R1 PIK3R2	4.01e-05	14	98	3	GO:0036312
GeneOntologyMolecularFunction	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity	GCNT2 GCNT4	7.13e-05	3	98	2	GO:0008109
GeneOntologyCellularComponent	anaphase-promoting complex	ANAPC1 ANAPC5 ANAPC7	1.60e-04	23	97	3	GO:0005680
Domain	Nck-associated_protein-1	NCKAP1 NCKAP1L	2.73e-05	2	98	2	IPR019137
Domain	Nckap1	NCKAP1 NCKAP1L	2.73e-05	2	98	2	PF09735
Domain	TPR	TMTC1 TRANK1 STIP1 TTC5 ANAPC5 ANAPC7	6.05e-05	129	98	6	SM00028
Domain	TPR_repeat	TMTC1 TRANK1 STIP1 TTC5 ANAPC5 ANAPC7	7.17e-05	133	98	6	IPR019734
Domain	PI3K_P85_iSH2	PIK3R1 PIK3R2	8.15e-05	3	98	2	IPR032498
Domain	PI3K_P85_iSH2	PIK3R1 PIK3R2	8.15e-05	3	98	2	PF16454
Domain	TPR_2	TMTC1 STIP1 TTC5 ANAPC7	1.36e-04	50	98	4	PF07719
Domain	TPR_2	TMTC1 STIP1 TTC5 ANAPC7	1.36e-04	50	98	4	IPR013105
Domain	TPR-contain_dom	TMTC1 TRANK1 STIP1 TTC5 ANAPC5 ANAPC7	1.39e-04	150	98	6	IPR013026
Domain	-	GTF2IRD2B GTF2IRD2	1.62e-04	4	98	2	3.90.1460.10
Domain	GTF2I	GTF2IRD2B GTF2IRD2	1.62e-04	4	98	2	PS51139
Domain	GTF2I	GTF2IRD2B GTF2IRD2	1.62e-04	4	98	2	PF02946
Domain	GTF2I	GTF2IRD2B GTF2IRD2	1.62e-04	4	98	2	IPR004212
Domain	SH3_1	NEB BAIAP2L1 PIK3R1 PIK3R2 BTK FCHSD1	2.26e-04	164	98	6	PF00018
Domain	TPR-like_helical_dom	AAR2 TMTC1 TRANK1 STIP1 TTC5 ANAPC5 ANAPC7	2.27e-04	233	98	7	IPR011990
Domain	TPR_REGION	TMTC1 TRANK1 STIP1 TTC5 ANAPC5 ANAPC7	2.34e-04	165	98	6	PS50293
Domain	TPR	TMTC1 TRANK1 STIP1 TTC5 ANAPC5 ANAPC7	2.34e-04	165	98	6	PS50005
Domain	PI3kinase_P85	PIK3R1 PIK3R2	2.70e-04	5	98	2	IPR001720
Domain	CLTH	RANBP9 GID8	4.03e-04	6	98	2	PF10607
Domain	CRA	RANBP9 GID8	4.03e-04	6	98	2	SM00757
Domain	CTLH/CRA	RANBP9 GID8	4.03e-04	6	98	2	IPR024964
Domain	CRA_dom	RANBP9 GID8	4.03e-04	6	98	2	IPR013144
Domain	Glyco_trans_14	GCNT2 GCNT4	7.48e-04	8	98	2	IPR003406
Domain	Branch	GCNT2 GCNT4	7.48e-04	8	98	2	PF02485
Domain	-	TMTC1 TRANK1 STIP1 TTC5 ANAPC5 ANAPC7	7.78e-04	207	98	6	1.25.40.10
Domain	CTLH	RANBP9 GID8	9.58e-04	9	98	2	SM00668
Domain	LisH	RANBP9 GID8	9.58e-04	9	98	2	PF08513
Domain	SH3	NEB BAIAP2L1 PIK3R1 PIK3R2 BTK FCHSD1	9.71e-04	216	98	6	SM00326
Domain	SH3	NEB BAIAP2L1 PIK3R1 PIK3R2 BTK FCHSD1	9.71e-04	216	98	6	PS50002
Domain	SH3_domain	NEB BAIAP2L1 PIK3R1 PIK3R2 BTK FCHSD1	1.07e-03	220	98	6	IPR001452
Domain	CTLH_C	RANBP9 GID8	1.19e-03	10	98	2	IPR006595
Domain	CTLH	RANBP9 GID8	1.19e-03	10	98	2	PS50897
Domain	-	FAM120B MARF1	1.74e-03	12	98	2	3.40.50.1010
Domain	Septin	SEPTIN3 SEPTIN12	2.05e-03	13	98	2	PF00735
Domain	G_SEPTIN_dom	SEPTIN3 SEPTIN12	2.05e-03	13	98	2	IPR030379
Domain	G_SEPTIN	SEPTIN3 SEPTIN12	2.05e-03	13	98	2	PS51719
Domain	PIN_domain-like	FAM120B MARF1	2.38e-03	14	98	2	IPR029060
Domain	Septin	SEPTIN3 SEPTIN12	2.38e-03	14	98	2	IPR016491
Domain	TPR_8	TMTC1 STIP1 ANAPC7	2.71e-03	53	98	3	PF13181
Domain	ALPHA_CA_2	CA10 PTPRG	3.52e-03	17	98	2	PS51144
Domain	Carb_anhydrase	CA10 PTPRG	3.52e-03	17	98	2	PF00194
Domain	Carb_anhydrase	CA10 PTPRG	3.52e-03	17	98	2	SM01057
Domain	-	CA10 PTPRG	3.52e-03	17	98	2	3.10.200.10
Domain	Carbonic_anhydrase_a	CA10 PTPRG	3.52e-03	17	98	2	IPR001148
Domain	RhoGAP	PIK3R1 PIK3R2 ARHGAP8	4.23e-03	62	98	3	SM00324
Domain	RhoGAP	PIK3R1 PIK3R2 ARHGAP8	4.43e-03	63	98	3	PF00620
Domain	RHOGAP	PIK3R1 PIK3R2 ARHGAP8	4.63e-03	64	98	3	PS50238
Domain	RhoGAP_dom	PIK3R1 PIK3R2 ARHGAP8	4.63e-03	64	98	3	IPR000198
Domain	-	PIK3R1 PIK3R2 ARHGAP8	4.63e-03	64	98	3	1.10.555.10
Pathway	REACTOME_ASSEMBLY_OF_THE_PRE_REPLICATIVE_COMPLEX	MCM4 ANAPC1 PSMD14 ANAPC5 ANAPC7	4.04e-05	81	67	5	MM15360
Pathway	REACTOME_RND1_GTPASE_CYCLE	PTPN13 PIK3R1 PIK3R2 STIP1	4.55e-05	42	67	4	M41828
Pathway	REACTOME_RND1_GTPASE_CYCLE	PTPN13 PIK3R1 PIK3R2 STIP1	5.00e-05	43	67	4	MM15679
Pathway	KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION	ANAPC1 PIK3R1 PIK3R2 ANAPC5 ANAPC7	5.10e-05	85	67	5	M3578
Pathway	KEGG_MEDICUS_REFERENCE_COHESIN_DISSOCIATION_IN_ANAPHASE	ANAPC1 ANAPC5 ANAPC7	5.50e-05	16	67	3	M47871
Pathway	KEGG_MEDICUS_PATHOGEN_HTLV_1_TAX_TO_SPINDLE_ASSEMBLY_CHECKPOINT_SIGNALING	ANAPC1 ANAPC5 ANAPC7	5.50e-05	16	67	3	M47476
Pathway	REACTOME_RAC2_GTPASE_CYCLE	NCKAP1 BAIAP2L1 PIK3R1 PIK3R2 NCKAP1L	5.70e-05	87	67	5	MM15600
Pathway	REACTOME_RAC2_GTPASE_CYCLE	NCKAP1 BAIAP2L1 PIK3R1 PIK3R2 NCKAP1L	6.02e-05	88	67	5	M41810
Pathway	KEGG_MEDICUS_REFERENCE_DISASSEMBLY_OF_MCC	ANAPC1 ANAPC5 ANAPC7	6.65e-05	17	67	3	M47888
Pathway	REACTOME_SWITCHING_OF_ORIGINS_TO_A_POST_REPLICATIVE_STATE	MCM4 ANAPC1 PSMD14 ANAPC5 ANAPC7	6.70e-05	90	67	5	MM15371
Pathway	REACTOME_SWITCHING_OF_ORIGINS_TO_A_POST_REPLICATIVE_STATE	MCM4 ANAPC1 PSMD14 ANAPC5 ANAPC7	7.45e-05	92	67	5	M27666
Pathway	REACTOME_RAC3_GTPASE_CYCLE	NCKAP1 BAIAP2L1 PIK3R1 PIK3R2 NCKAP1L	7.84e-05	93	67	5	MM15609
Pathway	REACTOME_RAC3_GTPASE_CYCLE	NCKAP1 BAIAP2L1 PIK3R1 PIK3R2 NCKAP1L	8.25e-05	94	67	5	M41818
Pathway	REACTOME_DNA_REPLICATION_PRE_INITIATION	MCM4 ANAPC1 PSMD14 ANAPC5 ANAPC7	9.58e-05	97	67	5	MM15369
Pathway	REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE	ANAPC1 ANAPC5 ANAPC7	1.10e-04	20	67	3	MM14688
Pathway	REACTOME_PHOSPHORYLATION_OF_THE_APC_C	ANAPC1 ANAPC5 ANAPC7	1.10e-04	20	67	3	MM14690
Pathway	REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE	ANAPC1 ANAPC5 ANAPC7	1.10e-04	20	67	3	M1044
Pathway	REACTOME_PHOSPHORYLATION_OF_THE_APC_C	ANAPC1 ANAPC5 ANAPC7	1.10e-04	20	67	3	M1050
Pathway	REACTOME_ABERRANT_REGULATION_OF_MITOTIC_EXIT_IN_CANCER_DUE_TO_RB1_DEFECTS	ANAPC1 ANAPC5 ANAPC7	1.10e-04	20	67	3	M39015
Pathway	REACTOME_SIGNALING_BY_VEGF	FLT1 NCKAP1 PIK3R1 PIK3R2 NCKAP1L	1.27e-04	103	67	5	MM14752
Pathway	REACTOME_INHIBITION_OF_THE_PROTEOLYTIC_ACTIVITY_OF_APC_C_REQUIRED_FOR_THE_ONSET_OF_ANAPHASE_BY_MITOTIC_SPINDLE_CHECKPOINT_COMPONENTS	ANAPC1 ANAPC5 ANAPC7	1.28e-04	21	67	3	M489
Pathway	KEGG_MEDICUS_REFERENCE_SPINDLE_ASSEMBLY_CHECKPOINT_SIGNALING	ANAPC1 ANAPC5 ANAPC7	1.28e-04	21	67	3	M47583
Pathway	REACTOME_INHIBITION_OF_THE_PROTEOLYTIC_ACTIVITY_OF_APC_C_REQUIRED_FOR_THE_ONSET_OF_ANAPHASE_BY_MITOTIC_SPINDLE_CHECKPOINT_COMPONENTS	ANAPC1 ANAPC5 ANAPC7	1.28e-04	21	67	3	MM14560
Pathway	REACTOME_SIGNALING_BY_VEGF	FLT1 NCKAP1 PIK3R1 PIK3R2 NCKAP1L	1.46e-04	106	67	5	M27077
Pathway	REACTOME_APC_C_CDC20_MEDIATED_DEGRADATION_OF_CYCLIN_B	ANAPC1 ANAPC5 ANAPC7	1.93e-04	24	67	3	MM14675
Pathway	REACTOME_APC_C_CDC20_MEDIATED_DEGRADATION_OF_CYCLIN_B	ANAPC1 ANAPC5 ANAPC7	1.93e-04	24	67	3	M1039
Pathway	REACTOME_FCGAMMA_RECEPTOR_FCGR_DEPENDENT_PHAGOCYTOSIS	NCKAP1 PIK3R1 PIK3R2 BTK NCKAP1L	2.05e-04	114	67	5	MM14814
Pathway	REACTOME_APC_CDC20_MEDIATED_DEGRADATION_OF_NEK2A	ANAPC1 ANAPC5 ANAPC7	2.47e-04	26	67	3	MM14697
Pathway	REACTOME_APC_CDC20_MEDIATED_DEGRADATION_OF_NEK2A	ANAPC1 ANAPC5 ANAPC7	2.47e-04	26	67	3	M1079
Pathway	REACTOME_SYNTHESIS_OF_DNA	MCM4 ANAPC1 PSMD14 ANAPC5 ANAPC7	2.71e-04	121	67	5	M5224
Pathway	REACTOME_DNA_REPLICATION	MCM4 ANAPC1 PSMD14 ANAPC5 ANAPC7	3.15e-04	125	67	5	MM15380
Pathway	REACTOME_TNFR1_MEDIATED_CERAMIDE_PRODUCTION	SMPD2 NSMAF	3.30e-04	6	67	2	M27492
Pathway	REACTOME_TNFR1_MEDIATED_CERAMIDE_PRODUCTION	SMPD2 NSMAF	3.30e-04	6	67	2	MM15220
Pathway	REACTOME_DAP12_SIGNALING	PIK3R1 PIK3R2 BTK	3.43e-04	29	67	3	M27171
Pathway	REACTOME_CDK_MEDIATED_PHOSPHORYLATION_AND_REMOVAL_OF_CDC6	ANAPC1 PSMD14 ANAPC5 ANAPC7	3.56e-04	71	67	4	MM15370
Pathway	REACTOME_APC_C_CDH1_MEDIATED_DEGRADATION_OF_CDC20_AND_OTHER_APC_C_CDH1_TARGETED_PROTEINS_IN_LATE_MITOSIS_EARLY_G1	ANAPC1 PSMD14 ANAPC5 ANAPC7	4.18e-04	74	67	4	MM14678
Pathway	REACTOME_APC_C_CDH1_MEDIATED_DEGRADATION_OF_CDC20_AND_OTHER_APC_C_CDH1_TARGETED_PROTEINS_IN_LATE_MITOSIS_EARLY_G1	ANAPC1 PSMD14 ANAPC5 ANAPC7	4.18e-04	74	67	4	M1030
Pathway	REACTOME_DAP12_SIGNALING	PIK3R1 PIK3R2 BTK	4.19e-04	31	67	3	MM14886
Pathway	REACTOME_SIGNALING_BY_LTK_IN_CANCER	PIK3R1 PIK3R2	4.60e-04	7	67	2	M48255
Pathway	WP_PI3KAKTMTOR_SIGNALING_AND_THERAPEUTIC_OPPORTUNITIES_IN_PROSTATE_CANCER	TFEB PIK3R1 PIK3R2	4.61e-04	32	67	3	M39445
Pathway	REACTOME_ACTIVATION_OF_APC_C_AND_APC_C_CDC20_MEDIATED_DEGRADATION_OF_MITOTIC_PROTEINS	ANAPC1 PSMD14 ANAPC5 ANAPC7	4.86e-04	77	67	4	MM14692
Pathway	REACTOME_RHO_GTPASES_ACTIVATE_WASPS_AND_WAVES	NCKAP1 BTK NCKAP1L	5.53e-04	34	67	3	MM15265
Pathway	REACTOME_FCGAMMA_RECEPTOR_FCGR_DEPENDENT_PHAGOCYTOSIS	NCKAP1 PIK3R1 PIK3R2 BTK NCKAP1L	5.84e-04	143	67	5	M27107
Pathway	REACTOME_REGULATION_OF_APC_C_ACTIVATORS_BETWEEN_G1_S_AND_EARLY_ANAPHASE	ANAPC1 ANAPC5 ANAPC7	6.02e-04	35	67	3	MM14689
Pathway	KEGG_MEDICUS_REFERENCE_HYDROLYSIS_OF_SPHINGOMYELIN	ACER1 SMPD2	6.12e-04	8	67	2	M47611
Pathway	REACTOME_PI3K_AKT_ACTIVATION	PIK3R1 PIK3R2	6.12e-04	8	67	2	MM14776
Pathway	REACTOME_S_PHASE	MCM4 ANAPC1 PSMD14 ANAPC5 ANAPC7	6.41e-04	146	67	5	MM15378
Pathway	KEGG_MEDICUS_REFERENCE_GF_RTK_PI3K_SIGNALING_PATHWAY	FLT1 FGF23 PIK3R1 PIK3R2	6.46e-04	83	67	4	M47961
Pathway	REACTOME_RHO_GTPASES_ACTIVATE_WASPS_AND_WAVES	NCKAP1 BTK NCKAP1L	6.55e-04	36	67	3	M27549
Pathway	PID_FAS_PATHWAY	PIK3R1 PIK3R2 BTK	7.69e-04	38	67	3	M94
Pathway	REACTOME_DISEASES_OF_MITOTIC_CELL_CYCLE	ANAPC1 ANAPC5 ANAPC7	7.69e-04	38	67	3	M39005
Pathway	REACTOME_APC_C_MEDIATED_DEGRADATION_OF_CELL_CYCLE_PROTEINS	ANAPC1 PSMD14 ANAPC5 ANAPC7	7.71e-04	87	67	4	MM14677
Pathway	KEGG_MEDICUS_REFERENCE_PDL_PD1_SHP_PI3K_SIGNALING_PATHWAY	PIK3R1 PIK3R2	7.84e-04	9	67	2	M47757
Pathway	KEGG_MEDICUS_REFERENCE_ICOSLG_ICOS_PI3K_SIGNALING_PATHWAY	PIK3R1 PIK3R2	7.84e-04	9	67	2	M47972
Pathway	REACTOME_PI3K_AKT_ACTIVATION	PIK3R1 PIK3R2	7.84e-04	9	67	2	M714
Pathway	REACTOME_APC_C_MEDIATED_DEGRADATION_OF_CELL_CYCLE_PROTEINS	ANAPC1 PSMD14 ANAPC5 ANAPC7	8.05e-04	88	67	4	M29582
Pathway	REACTOME_SENESCENCE_ASSOCIATED_SECRETORY_PHENOTYPE_SASP	ANAPC1 ANAPC5 ANAPC7	8.30e-04	39	67	3	MM14900
Pathway	KEGG_MEDICUS_REFERENCE_GF_RTK_RAS_PI3K_SIGNALING_PATHWAY	FLT1 FGF23 PIK3R1 PIK3R2	8.40e-04	89	67	4	M47963
Pathway	WP_IL5_SIGNALING	PIK3R1 PIK3R2 BTK	8.94e-04	40	67	3	M39392
Pathway	WP_MICROGLIA_PATHOGEN_PHAGOCYTOSIS_PATHWAY	PIK3R1 PIK3R2 NCKAP1L	8.94e-04	40	67	3	M39695
Pathway	REACTOME_SIGNALING_BY_RHO_GTPASES_MIRO_GTPASES_AND_RHOBTB3	NCKAP1 PTPN13 BAIAP2L1 PIK3R1 PIK3R2 BTK STIP1 ZW10 ARHGAP8 NCKAP1L	9.21e-04	649	67	10	MM15690
Pathway	REACTOME_DNA_REPLICATION_PRE_INITIATION	MCM4 ANAPC1 PSMD14 ANAPC5 ANAPC7	9.42e-04	159	67	5	M27665
Pathway	REACTOME_TRANSCRIPTIONAL_REGULATION_BY_VENTX	ANAPC1 ANAPC5 ANAPC7	9.61e-04	41	67	3	M29748
Pathway	REACTOME_IRS_MEDIATED_SIGNALLING	FGF23 PIK3R1 PIK3R2	9.61e-04	41	67	3	MM14505
Pathway	REACTOME_RHOF_GTPASE_CYCLE	BAIAP2L1 PIK3R1 PIK3R2	9.61e-04	41	67	3	MM15630
Pathway	REACTOME_RND3_GTPASE_CYCLE	PTPN13 PIK3R1 PIK3R2	1.03e-03	42	67	3	M41826
Pathway	REACTOME_RHOF_GTPASE_CYCLE	BAIAP2L1 PIK3R1 PIK3R2	1.03e-03	42	67	3	M41821
Pathway	REACTOME_RND3_GTPASE_CYCLE	PTPN13 PIK3R1 PIK3R2	1.03e-03	42	67	3	MM15677
Pathway	REACTOME_S_PHASE	MCM4 ANAPC1 PSMD14 ANAPC5 ANAPC7	1.05e-03	163	67	5	M3158
Pathway	REACTOME_RHO_GTPASE_CYCLE	NCKAP1 PTPN13 BAIAP2L1 PIK3R1 PIK3R2 STIP1 ARHGAP8 NCKAP1L	1.08e-03	439	67	8	MM15595
Pathway	REACTOME_RND2_GTPASE_CYCLE	PTPN13 PIK3R1 PIK3R2	1.11e-03	43	67	3	M41827
Pathway	PID_ERBB2_ERBB3_PATHWAY	CHRNE PIK3R1 PIK3R2	1.18e-03	44	67	3	M175
Pathway	REACTOME_RND2_GTPASE_CYCLE	PTPN13 PIK3R1 PIK3R2	1.18e-03	44	67	3	MM15678
Pathway	REACTOME_SIGNALING_BY_LTK	PIK3R1 PIK3R2	1.19e-03	11	67	2	MM17235
Pathway	REACTOME_RHO_GTPASE_CYCLE	NCKAP1 PTPN13 BAIAP2L1 PIK3R1 PIK3R2 STIP1 ARHGAP8 NCKAP1L	1.27e-03	450	67	8	M27078
Pathway	REACTOME_DAP12_INTERACTIONS	PIK3R1 PIK3R2 BTK	1.35e-03	46	67	3	M27151
Pathway	WP_MICROGLIA_PATHOGEN_PHAGOCYTOSIS_PATHWAY	PIK3R1 PIK3R2 NCKAP1L	1.35e-03	46	67	3	MM15837
Pathway	REACTOME_SIGNALING_BY_LTK	PIK3R1 PIK3R2	1.42e-03	12	67	2	M48256
Pathway	REACTOME_SIGNALING_BY_PDGFRA_TRANSMEMBRANE_JUXTAMEMBRANE_AND_KINASE_DOMAIN_MUTANTS	PIK3R1 PIK3R2	1.42e-03	12	67	2	M29851
Pathway	REACTOME_SIGNALING_BY_TYPE_1_INSULIN_LIKE_GROWTH_FACTOR_1_RECEPTOR_IGF1R	FGF23 PIK3R1 PIK3R2	1.43e-03	47	67	3	MM14885
Pathway	REACTOME_RAC1_GTPASE_CYCLE	NCKAP1 BAIAP2L1 PIK3R1 PIK3R2 NCKAP1L	1.44e-03	175	67	5	MM15599
Pathway	REACTOME_IRS_MEDIATED_SIGNALLING	FGF23 PIK3R1 PIK3R2	1.52e-03	48	67	3	M26916
Pathway	PID_PI3KCI_PATHWAY	PIK3R1 PIK3R2 BTK	1.52e-03	48	67	3	M141
Pathway	REACTOME_INSULIN_RECEPTOR_SIGNALLING_CASCADE	FGF23 PIK3R1 PIK3R2	1.52e-03	48	67	3	MM15441
Pathway	REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE	PTPN13 PIK3R1 PIK3R2	1.71e-03	50	67	3	MM14641
Pathway	REACTOME_CELL_CYCLE_CHECKPOINTS	MCM4 ANAPC1 ZW10 PSMD14 ANAPC5 ANAPC7	1.79e-03	271	67	6	MM15388
Pathway	REACTOME_RAC1_GTPASE_CYCLE	NCKAP1 BAIAP2L1 PIK3R1 PIK3R2 NCKAP1L	1.80e-03	184	67	5	M41809
Pathway	REACTOME_MITOTIC_SPINDLE_CHECKPOINT	ANAPC1 ZW10 ANAPC5 ANAPC7	1.91e-03	111	67	4	M27673
Pathway	REACTOME_DNA_REPLICATION	MCM4 ANAPC1 PSMD14 ANAPC5 ANAPC7	1.93e-03	187	67	5	M1017
Pathway	WP_CANCER_IMMUNOTHERAPY_BY_CTLA4_BLOCKADE	PIK3R1 PIK3R2	1.95e-03	14	67	2	M39840
Pathway	REACTOME_SIGNALING_BY_RHO_GTPASES_MIRO_GTPASES_AND_RHOBTB3	NCKAP1 PTPN13 BAIAP2L1 PIK3R1 PIK3R2 BTK STIP1 ZW10 ARHGAP8 NCKAP1L	2.01e-03	720	67	10	M41838
Pathway	REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE	PTPN13 PIK3R1 PIK3R2	2.03e-03	53	67	3	M662
Pathway	REACTOME_SEPARATION_OF_SISTER_CHROMATIDS	ANAPC1 ZW10 PSMD14 ANAPC5 ANAPC7	2.12e-03	191	67	5	M29614
Pathway	REACTOME_SIGNALING_BY_TYPE_1_INSULIN_LIKE_GROWTH_FACTOR_1_RECEPTOR_IGF1R	FGF23 PIK3R1 PIK3R2	2.14e-03	54	67	3	M27168
Pathway	REACTOME_DAP12_INTERACTIONS	PIK3R1 PIK3R2 BTK	2.14e-03	54	67	3	MM14871
Pathway	REACTOME_INSULIN_RECEPTOR_SIGNALLING_CASCADE	FGF23 PIK3R1 PIK3R2	2.14e-03	54	67	3	M620
Pathway	REACTOME_SEPARATION_OF_SISTER_CHROMATIDS	ANAPC1 ZW10 PSMD14 ANAPC5 ANAPC7	2.22e-03	193	67	5	MM14890
Pathway	KEGG_MEDICUS_REFERENCE_BCR_BCAP_CD19_PI3K_SIGNALING_PATHWAY	PIK3R1 PIK3R2	2.25e-03	15	67	2	M47971
Pathway	REACTOME_INTERLEUKIN_7_SIGNALING	PIK3R1 PIK3R2	2.25e-03	15	67	2	MM14536
Pathway	REACTOME_MITOTIC_SPINDLE_CHECKPOINT	ANAPC1 ZW10 ANAPC5 ANAPC7	2.31e-03	117	67	4	MM15387
Pubmed	Charting the landscape of tandem BRCT domain-mediated protein interactions.	DNHD1 TRAPPC11 ERF WBP1L RANBP9 MCM4 CUBN AURKC ANAPC1 PREP TBC1D1 CATSPERG ANAPC5 ANAPC7	6.24e-09	670	98	14	22990118
Pubmed	The emerging role of APC/CCdh1 in controlling differentiation, genomic stability and tumor suppression.	ANAPC1 ANAPC5 ANAPC7	2.16e-07	5	98	3	19826416
Pubmed	Human Immunodeficiency Virus Type 1 Nef Inhibits Autophagy through Transcription Factor EB Sequestration.	TFEB ATG9B TLR8	7.53e-07	7	98	3	26115100
Pubmed	Tec tyrosine kinase links the cytokine receptors to PI-3 kinase probably through JAK.	PIK3R1 PIK3R2 BTK	7.53e-07	7	98	3	9178903
Pubmed	Inactivation and disassembly of the anaphase-promoting complex during human cytomegalovirus infection is associated with degradation of the APC5 and APC4 subunits and does not require UL97-mediated phosphorylation of Cdh1.	ANAPC1 ANAPC5 ANAPC7	1.20e-06	8	98	3	20686030
Pubmed	Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1 domain-containing protein with homology to tensin.	RANBP9 PIK3R1 PIK3R2	1.80e-06	9	98	3	12470648
Pubmed	Expression of the CDH1-associated form of the anaphase-promoting complex in postmitotic neurons.	ANAPC1 ANAPC5 ANAPC7	2.57e-06	10	98	3	10500174
Pubmed	Characterization of the DOC1/APC10 subunit of the yeast and the human anaphase-promoting complex.	ANAPC1 ANAPC5 ANAPC7	2.57e-06	10	98	3	10318877
Pubmed	FBXL2- and PTPL1-mediated degradation of p110-free p85β regulatory subunit controls the PI(3)K signalling cascade.	PTPN13 PIK3R1 PIK3R2	3.52e-06	11	98	3	23604317
Pubmed	Mitotic regulation of the human anaphase-promoting complex by phosphorylation.	ANAPC1 ANAPC5 ANAPC7	4.69e-06	12	98	3	14657031
Pubmed	Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C.	ANAPC1 ANAPC5 ANAPC7	4.69e-06	12	98	3	16364912
Pubmed	The G2/M regulator histone demethylase PHF8 is targeted for degradation by the anaphase-promoting complex containing CDC20.	ANAPC1 ANAPC5 ANAPC7	6.08e-06	13	98	3	23979597
Pubmed	Emi1 stably binds and inhibits the anaphase-promoting complex/cyclosome as a pseudosubstrate inhibitor.	ANAPC1 ANAPC5 ANAPC7	6.08e-06	13	98	3	16921029
Pubmed	Deubiquitylase USP9X suppresses tumorigenesis by stabilizing large tumor suppressor kinase 2 (LATS2) in the Hippo pathway.	ANAPC1 ANAPC5 ANAPC7	7.72e-06	14	98	3	29183995
Pubmed	Characterization of vertebrate cohesin complexes and their regulation in prophase.	ANAPC1 ANAPC5 ANAPC7	7.72e-06	14	98	3	11076961
Pubmed	Anthrax lethal factor cleaves regulatory subunits of phosphoinositide-3 kinase to contribute to toxin lethality.	PIK3R1 PIK3R2	7.86e-06	2	98	2	32895527
Pubmed	Localization and subcellular distribution of prolyl oligopeptidase in the mouse placenta.	FLT1 PREP	7.86e-06	2	98	2	21544597
Pubmed	Xid-like immunodeficiency in mice with disruption of the p85alpha subunit of phosphoinositide 3-kinase.	PIK3R1 BTK	7.86e-06	2	98	2	9888854
Pubmed	Frontline: The p85alpha isoform of phosphoinositide 3-kinase is essential for a subset of B cell receptor-initiated signaling responses.	PIK3R1 BTK	7.86e-06	2	98	2	15384044
Pubmed	Class IA phosphoinositide 3-kinase regulates heart size and physiological cardiac hypertrophy.	PIK3R1 PIK3R2	7.86e-06	2	98	2	16227599
Pubmed	Divergent regulation of hepatic glucose and lipid metabolism by phosphoinositide 3-kinase via Akt and PKClambda/zeta.	PIK3R1 PIK3R2	7.86e-06	2	98	2	16679292
Pubmed	Loss of class IA PI3K signaling in muscle leads to impaired muscle growth, insulin response, and hyperlipidemia.	PIK3R1 PIK3R2	7.86e-06	2	98	2	16679293
Pubmed	Molecular mechanism behind rotavirus NSP1-mediated PI3 kinase activation: interaction between NSP1 and the p85 subunit of PI3 kinase.	PIK3R1 PIK3R2	7.86e-06	2	98	2	23221569
Pubmed	Interaction of the Flt-1 tyrosine kinase receptor with the p85 subunit of phosphatidylinositol 3-kinase. Mapping of a novel site involved in binding.	FLT1 PIK3R1	7.86e-06	2	98	2	7657594
Pubmed	Genetic reduction of class IA PI-3 kinase activity alters fetal hematopoiesis and competitive repopulating ability of hematopoietic stem cells in vivo.	PIK3R1 PIK3R2	7.86e-06	2	98	2	16239435
Pubmed	Acute inhibition of PI3K-PDK1-Akt pathway potentiates insulin secretion through upregulation of newcomer granule fusions in pancreatic β-cells.	PIK3R1 PIK3R2	7.86e-06	2	98	2	23077605
Pubmed	Class IA phosphatidylinositol 3-kinase in pancreatic β cells controls insulin secretion by multiple mechanisms.	PIK3R1 PIK3R2	7.86e-06	2	98	2	21109194
Pubmed	PI3K and Btk differentially regulate B cell antigen receptor-mediated signal transduction.	PIK3R1 BTK	7.86e-06	2	98	2	12563258
Pubmed	Cross-talk between APC/C and CBP/p300.	ANAPC5 ANAPC7	7.86e-06	2	98	2	16861917
Pubmed	Soluble FLT1 binds lipid microdomains in podocytes to control cell morphology and glomerular barrier function.	FLT1 TCF21	7.86e-06	2	98	2	23063127
Pubmed	Pan-cancer analysis on the role of PIK3R1 and PIK3R2 in human tumors.	PIK3R1 PIK3R2	7.86e-06	2	98	2	35395865
Pubmed	T-cell function is partially maintained in the absence of class IA phosphoinositide 3-kinase signaling.	PIK3R1 PIK3R2	7.86e-06	2	98	2	17164340
Pubmed	Mechanism of influenza A virus NS1 protein interaction with the p85beta, but not the p85alpha, subunit of phosphatidylinositol 3-kinase (PI3K) and up-regulation of PI3K activity.	PIK3R1 PIK3R2	7.86e-06	2	98	2	18534979
Pubmed	Sjögren's syndrome-like disease in mice with T cells lacking class 1A phosphoinositide-3-kinase.	PIK3R1 PIK3R2	7.86e-06	2	98	2	17071741
Pubmed	Intracellular movement of green fluorescent protein-tagged phosphatidylinositol 3-kinase in response to growth factor receptor signaling.	PIK3R1 PIK3R2	7.86e-06	2	98	2	10459020
Pubmed	Role of phosphoinositide 3-kinase regulatory isoforms in development and actin rearrangement.	PIK3R1 PIK3R2	7.86e-06	2	98	2	15767666
Pubmed	Comparison of TFII-I gene family members deleted in Williams-Beuren syndrome.	GTF2IRD2B GTF2IRD2	7.86e-06	2	98	2	15388857
Pubmed	The HEM proteins: a novel family of tissue-specific transmembrane proteins expressed from invertebrates through mammals with an essential function in oogenesis.	NCKAP1 NCKAP1L	7.86e-06	2	98	2	7643388
Pubmed	Chromosomal localization of human p85 alpha, a subunit of phosphatidylinositol 3-kinase, and its homologue p85 beta.	PIK3R1 PIK3R2	7.86e-06	2	98	2	1314371
Pubmed	The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex.	ANAPC1 ANAPC5 ANAPC7	9.63e-06	15	98	3	10922056
Pubmed	APC15 mediates CDC20 autoubiquitylation by APC/C(MCC) and disassembly of the mitotic checkpoint complex.	ANAPC1 ANAPC5 ANAPC7	9.63e-06	15	98	3	23007861
Pubmed	Accumulation of cyclin B1 requires E2F and cyclin-A-dependent rearrangement of the anaphase-promoting complex.	ANAPC1 ANAPC5 ANAPC7	1.18e-05	16	98	3	10548110
Pubmed	The anaphase-promoting complex: a key factor in the regulation of cell cycle.	ANAPC1 ANAPC5 ANAPC7	1.18e-05	16	98	3	15678131
Pubmed	Mechanism of polyubiquitination by human anaphase-promoting complex: RING repurposing for ubiquitin chain assembly.	ANAPC1 ANAPC5 ANAPC7	1.18e-05	16	98	3	25306923
Pubmed	Human securin proteolysis is controlled by the spindle checkpoint and reveals when the APC/C switches from activation by Cdc20 to Cdh1.	ANAPC1 ANAPC5 ANAPC7	1.43e-05	17	98	3	12070128
Pubmed	Transcriptional intermediary factor 1γ binds to the anaphase-promoting complex/cyclosome and promotes mitosis.	ANAPC1 ANAPC5 ANAPC7	1.43e-05	17	98	3	23160376
Pubmed	A conserved cyclin-binding domain determines functional interplay between anaphase-promoting complex-Cdh1 and cyclin A-Cdk2 during cell cycle progression.	ANAPC1 ANAPC5 ANAPC7	1.43e-05	17	98	3	11340163
Pubmed	TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1.	ANAPC1 ANAPC5 ANAPC7	1.43e-05	17	98	3	12956947
Pubmed	Atomic structure of the APC/C and its mechanism of protein ubiquitination.	ANAPC1 ANAPC5 ANAPC7	1.43e-05	17	98	3	26083744
Pubmed	Assembly and Function of Heterotypic Ubiquitin Chains in Cell-Cycle and Protein Quality Control.	ANAPC1 ANAPC5 ANAPC7	1.43e-05	17	98	3	29033132
Pubmed	Lesson from the stoichiometry determination of the cohesin complex: a short protease mediated elution increases the recovery from cross-linked antibody-conjugated beads.	ANAPC1 ANAPC5 ANAPC7	1.43e-05	17	98	3	21043528
Pubmed	Mechanism of APC/CCDC20 activation by mitotic phosphorylation.	ANAPC1 ANAPC5 ANAPC7	1.43e-05	17	98	3	27114510
Pubmed	Recombinant expression, reconstitution and structure of human anaphase-promoting complex (APC/C).	ANAPC1 ANAPC5 ANAPC7	1.43e-05	17	98	3	23078409
Pubmed	BubR1 blocks substrate recruitment to the APC/C in a KEN-box-dependent manner.	ANAPC1 ANAPC5 ANAPC7	1.72e-05	18	98	3	22193957
Pubmed	Mitotic regulation of the APC activator proteins CDC20 and CDH1.	ANAPC1 ANAPC5 ANAPC7	1.72e-05	18	98	3	10793135
Pubmed	The mitotic checkpoint: a signaling pathway that allows a single unattached kinetochore to inhibit mitotic exit.	ANAPC1 ANAPC5 ANAPC7	1.72e-05	18	98	3	14593737
Pubmed	Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2.	ANAPC1 ANAPC5 ANAPC7	1.72e-05	18	98	3	11535616
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	ERF NCKAP1 RANBP9 MCM4 PCARE AAR2 PTPN13 PTPRG PIK3R1 TBC1D1 MARF1 GID8 ZW10 ANAPC7	2.02e-05	1321	98	14	27173435
Pubmed	Molecular mechanism of APC/C activation by mitotic phosphorylation.	ANAPC1 ANAPC5 ANAPC7	2.03e-05	19	98	3	27120157
Pubmed	Molecular architecture and mechanism of the anaphase-promoting complex.	ANAPC1 ANAPC5 ANAPC7	2.03e-05	19	98	3	25043029
Pubmed	Structure of an APC3-APC16 complex: insights into assembly of the anaphase-promoting complex/cyclosome.	ANAPC1 ANAPC5 ANAPC7	2.03e-05	19	98	3	25490258
Pubmed	Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85alpha.	PIK3R1 BTK	2.35e-05	3	98	2	9888855
Pubmed	Modulation of epithelial neoplasia and lymphoid hyperplasia in PTEN+/- mice by the p85 regulatory subunits of phosphoinositide 3-kinase.	PIK3R1 PIK3R2	2.35e-05	3	98	2	16006513
Pubmed	Transforming activity of receptor tyrosine kinase tyro3 is mediated, at least in part, by the PI3 kinase-signaling pathway.	PIK3R1 PIK3R2	2.35e-05	3	98	2	10627473
Pubmed	RanBP9 controls the oligomeric state of CTLH complex assemblies.	RANBP9 GID8	2.35e-05	3	98	2	36621627
Pubmed	BCR targets cyclin D2 via Btk and the p85alpha subunit of PI3-K to induce cell cycle progression in primary mouse B cells.	PIK3R1 BTK	2.35e-05	3	98	2	12700661
Pubmed	Altered splenic B cell subset development in mice lacking phosphoinositide 3-kinase p85alpha.	PIK3R1 BTK	2.35e-05	3	98	2	15520044
Pubmed	Class 1A PI3K regulates vessel integrity during development and tumorigenesis.	PIK3R1 PIK3R2	2.35e-05	3	98	2	18621722
Pubmed	Hyperosmotic stress inhibits insulin receptor substrate-1 function by distinct mechanisms in 3T3-L1 adipocytes.	PIK3R1 PIK3R2	2.35e-05	3	98	2	12730242
Pubmed	Reduced T cell expansion by a superantigen as a result of impaired B cell development in mice deficient for the p85alpha regulatory subunit of PI3K.	PIK3R1 BTK	2.35e-05	3	98	2	20007249
Pubmed	The covalent modification and regulation of TLR8 in HEK-293 cells stimulated with imidazoquinoline agonists.	TLR8 PIK3R1	2.35e-05	3	98	2	17868034
Pubmed	The p85beta regulatory subunit of phosphoinositide 3-kinase has unique and redundant functions in B cells.	PIK3R1 PIK3R2	2.35e-05	3	98	2	19811262
Pubmed	T cell Ig and mucin domain-1-mediated T cell activation requires recruitment and activation of phosphoinositide 3-kinase.	PIK3R1 PIK3R2	2.35e-05	3	98	2	18453570
Pubmed	SHP-2 and PI3-kinase genes PTPN11 and PIK3R1 may influence serum apoB and LDL cholesterol levels in normal women.	APOB PIK3R1	2.35e-05	3	98	2	17214991
Pubmed	High frequency of PIK3R1 and PIK3R2 mutations in endometrial cancer elucidates a novel mechanism for regulation of PTEN protein stability.	PIK3R1 PIK3R2	2.35e-05	3	98	2	21984976
Pubmed	Activation of the Eck receptor protein tyrosine kinase stimulates phosphatidylinositol 3-kinase activity.	PIK3R1 PIK3R2	2.35e-05	3	98	2	7982920
Pubmed	Innate Immune Signals Induce Anterograde Endosome Transport Promoting MHC Class I Cross-Presentation.	LNPEP TBC1D1	2.35e-05	3	98	2	30257216
Pubmed	PI3-kinase activity modulates apo B available for hepatic VLDL production in apobec-1-/- mice.	APOB PIK3R1	2.35e-05	3	98	2	16798720
Pubmed	Isolation and characterisation of GTF2IRD2, a novel fusion gene and member of the TFII-I family of transcription factors, deleted in Williams-Beuren syndrome.	GTF2IRD2B GTF2IRD2	2.35e-05	3	98	2	15100712
Pubmed	PERK utilizes intrinsic lipid kinase activity to generate phosphatidic acid, mediate Akt activation, and promote adipocyte differentiation.	PIK3R1 PIK3R2	2.35e-05	3	98	2	22493067
Pubmed	Mesothelin inhibits paclitaxel-induced apoptosis through the PI3K pathway.	PIK3R1 PIK3R2	2.35e-05	3	98	2	19747165
Pubmed	A novel interaction between fibroblast growth factor receptor 3 and the p85 subunit of phosphoinositide 3-kinase: activation-dependent regulation of ERK by p85 in multiple myeloma cells.	PIK3R1 PIK3R2	2.35e-05	3	98	2	19286672
Pubmed	Signaling by Toll-like receptors 8 and 9 requires Bruton's tyrosine kinase.	TLR8 BTK	2.35e-05	3	98	2	17932028
Pubmed	p85 Associates with unphosphorylated PTEN and the PTEN-associated complex.	PIK3R1 PIK3R2	2.35e-05	3	98	2	19635806
Pubmed	Stimulation of CD28 triggers an association between CD28 and phosphatidylinositol 3-kinase in Jurkat T cells.	PIK3R1 PIK3R2	2.35e-05	3	98	2	7509360
Pubmed	APC/C-mediated destruction of the centrosomal kinase Nek2A occurs in early mitosis and depends upon a cyclin A-type D-box.	ANAPC1 ANAPC5 ANAPC7	2.39e-05	20	98	3	11742988
Pubmed	Identification of novel human Cdt1-binding proteins by a proteomics approach: proteolytic regulation by APC/CCdh1.	MCM4 ANAPC5 ANAPC7	2.39e-05	20	98	3	18162579
Pubmed	Mammalian Cdh1/Fzr mediates its own degradation.	ANAPC1 PSMD14 ANAPC5 ANAPC7	2.40e-05	59	98	4	15029244
Pubmed	Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex.	ANAPC1 ANAPC5 ANAPC7	2.78e-05	21	98	3	18485873
Pubmed	A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing.	NCKAP1 RANBP9 MCM4 AAR2 BAIAP2L1 ANAPC1 TIMELESS ANAPC5 ANAPC7	3.01e-05	560	98	9	35241646
Pubmed	NYAP: a phosphoprotein family that links PI3K to WAVE1 signalling in neurons.	NCKAP1 PIK3R1 PIK3R2	3.21e-05	22	98	3	21946561
Pubmed	EG-1 interacts with c-Src and activates its signaling pathway.	PIK3R1 PIK3R2 BTK	3.21e-05	22	98	3	16964398
Pubmed	NOTCH1 nuclear interactome reveals key regulators of its transcriptional activity and oncogenic function.	RANBP9 ANAPC1 ANAPC5 ANAPC7 NCKAP1L	3.35e-05	129	98	5	23022380
Pubmed	Anaphase-promoting complex/cyclosome-dependent proteolysis of human cyclin A starts at the beginning of mitosis and is not subject to the spindle assembly checkpoint.	ANAPC1 PSMD14 ANAPC5 ANAPC7	3.96e-05	67	98	4	11285280
Pubmed	A proteomics approach for the identification of cullin-9 (CUL9) related signaling pathways in induced pluripotent stem cell models.	ANAPC1 ANAPC5 ANAPC7	4.21e-05	24	98	3	33705438
Pubmed	Phosphorylation-dependent interaction of the N-methyl-D-aspartate receptor epsilon 2 subunit with phosphatidylinositol 3-kinase.	PIK3R1 PIK3R2	4.70e-05	4	98	2	10620012
Pubmed	Molecular phylogeny of a RING E3 ubiquitin ligase, conserved in eukaryotic cells and dominated by homologous components, the muskelin/RanBPM/CTLH complex.	RANBP9 GID8	4.70e-05	4	98	2	24143168
Pubmed	TGF-beta 1 modulates EGF-stimulated phosphatidylinositol 3-kinase activity in human airway smooth muscle cells.	PIK3R1 PIK3R2	4.70e-05	4	98	2	9435577
Pubmed	Phosphoinositide 3-kinase binds constitutively to alpha/beta-tubulin and binds to gamma-tubulin in response to insulin.	PIK3R1 PIK3R2	4.70e-05	4	98	2	7592789
Pubmed	Bruton's tyrosine kinase regulates TLR7/8-induced TNF transcription via nuclear factor-κB recruitment.	TLR8 BTK	4.70e-05	4	98	2	29567473
Interaction	TLR8 interactions	TLR8 PIK3R1 BTK	1.27e-05	10	97	3	int:TLR8
Interaction	EPHA1 interactions	USP34 DYM STK17B HIP1R PTPN13 BAIAP2L1 PIK3R1 PIK3R2	1.80e-05	235	97	8	int:EPHA1
Interaction	PPARD interactions	USP34 ERF RNF31 RANBP9 PSMD14 ANAPC7	2.16e-05	117	97	6	int:PPARD
Interaction	ROR1 interactions	FLT1 BAIAP2L1 PIK3R1 TBC1D1 PIK3R2 BTK	3.29e-05	126	97	6	int:ROR1
Cytoband	22q13.2	EFCAB6 SEPTIN3 RRP7A	2.95e-04	60	98	3	22q13.2
GeneFamily	Anaphase promoting complex \|Tetratricopeptide repeat domain containing	ANAPC1 ANAPC5 ANAPC7	1.43e-05	14	63	3	402
GeneFamily	Tetratricopeptide repeat domain containing\|Bardet-Biedl syndrome associated\|BBSome	TMTC1 TRANK1 STIP1 TTC5 ANAPC7	5.00e-05	115	63	5	769
GeneFamily	Glucosaminyl (N-acetyl) transferases/xylosyltransferases	GCNT2 GCNT4	3.30e-04	8	63	2	441
GeneFamily	Septins	SEPTIN3 SEPTIN12	9.09e-04	13	63	2	732
Coexpression	GSE41867_LCMV_ARMSTRONG_VS_CLONE13_DAY15_EFFECTOR_CD8_TCELL_UP	FLT1 RNF31 TTI2 ZNF217 REST ACVR1B GID8 TMEM39A	8.74e-07	200	98	8	M9522
Coexpression	HASLINGER_B_CLL_WITH_CHROMOSOME_12_TRISOMY	HIP1R TIMELESS ANAPC5 NCKAP1L	1.54e-06	23	98	4	M1536
Coexpression	GSE26727_WT_VS_KLF2_KO_LPS_STIM_MACROPHAGE_DN	WBP1L RANBP9 ZBTB24 RRP7A TIMELESS PSMD14 NSMAF	1.04e-05	200	98	7	M8302
Coexpression	WAESCH_ANAPHASE_PROMOTING_COMPLEX	ANAPC1 ANAPC5 ANAPC7	1.41e-05	13	98	3	M7890
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EFCAB6 APOB NEB RYR2 TRANK1 UNC79 ADGRL3	1.72e-07	184	98	7	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EFCAB6 APOB NEB RYR2 TRANK1 UNC79 ADGRL3	1.72e-07	184	98	7	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EFCAB6 APOB NEB RYR2 TRANK1 UNC79 ADGRL3	1.72e-07	184	98	7	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ATG9B FLT1 DYSF RYR2 TMTC1 EFR3B	4.50e-06	194	98	6	a429d22c8c9d0fd3bfa9f877a6364cecad68db30
ToppCell	Bronchial-10x5prime-Stromal-Myofibroblastic-Muscle_perivascular_immune_recruiting\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	TCF21 RYR2 PTPRG ADAMTS9 TMEM179 ADGRL3	5.06e-06	198	98	6	dc6d9032c5029527e184ac13b887c0c1f22ef1c0
ToppCell	facs-Lung-3m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CUBN RYR2 CHRNE AURKC SEPTIN3	1.91e-05	148	98	5	5983c4546f527a0b599cfcbd8a6cb937a1d6f895
ToppCell	TCGA-Kidney-Solid_Tissue_Normal-Kidney-Kidney_normal_tissue\|TCGA-Kidney / Sample_Type by Project: Shred V9	TCF21 PCARE NDST3 SLC9A3 RASL11B	2.95e-05	162	98	5	a0367e9af78e4699b9d89d3e0597589e644f844c
ToppCell	TCGA-Kidney-Solid_Tissue_Normal-Kidney\|TCGA-Kidney / Sample_Type by Project: Shred V9	TCF21 PCARE NDST3 SLC9A3 RASL11B	2.95e-05	162	98	5	d007ec42d6458431f6c490df61de7a9caef857f0
ToppCell	TCGA-Kidney-Solid_Tissue_Normal\|TCGA-Kidney / Sample_Type by Project: Shred V9	TCF21 PCARE NDST3 SLC9A3 RASL11B	2.95e-05	162	98	5	65549ffdbfe8619693345db78e6ddbdde7b742c9
ToppCell	droplet-Lung-21m-Hematologic-myeloid-classical_monocyte-classical_monocyte_l2-17-52\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ATG9B ACVR1B BAIAP2L1 GTF2IRD2 NCKAP1L	3.22e-05	165	98	5	354978d4f35154d7b2e36e94de669e045adef512
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FLT1 DYSF RYR2 TMTC1 SKOR1	3.31e-05	166	98	5	ec719368295133da2f7ff587c5329ed6db1dd56d
ToppCell	facs-Diaphragm-Limb_Muscle-24m\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ERF CUBN RYR2 TRANK1 UNC79	3.61e-05	169	98	5	12bdc709bc000d7f9061ecd9fbd57233eaacb7e2
ToppCell	droplet-Pancreas-Exocrine-21m-Epithelial-pancreatic_ductal_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EFCAB6 ACVR1B TRANK1 FAM216B ARHGAP8	4.15e-05	174	98	5	a0ccda8fd6f55251cdeff24cf66e72e4a31d2104
ToppCell	390C-Endothelial_cells-Endothelial-E-\|390C / Donor, Lineage, Cell class and subclass (all cells)	FLT1 DYSF TMTC1 ADAMTS9 UNC79	4.62e-05	178	98	5	804ac3725c1f88e2212172bfb9aa01d97a735621
ToppCell	390C-Endothelial_cells-Endothelial-E\|390C / Donor, Lineage, Cell class and subclass (all cells)	FLT1 DYSF TMTC1 ADAMTS9 UNC79	4.62e-05	178	98	5	ad6dc4a375664c919bd48c35c48a561fc5a7de8c
ToppCell	severe-CD8+_T_naive\|severe / disease stage, cell group and cell class	DNHD1 GBE1 ZW10 ARHGAP8 FCHSD1	4.87e-05	180	98	5	94fe530367b170777f4051a4034cff06d80dbb83
ToppCell	COVID-19-Endothelial_cells-Endothelial_cells_(other)\|COVID-19 / group, cell type (main and fine annotations)	FLT1 TMTC1 PTPRG ADAMTS9 ADGRL3	5.00e-05	181	98	5	26eb4ee57a70dbf54e096b73129fda9dfda1f6ec
ToppCell	COVID-19-Heart-Fib_+_EC_+_Pericyte\|COVID-19 / Disease (COVID-19 only), tissue and cell type	FLT1 TMTC1 PTPRG ADAMTS9 ADGRL3	5.13e-05	182	98	5	fbd5e332df73bf7141c822fa67b76367dc962017
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ATG9B FLT1 DYSF RYR2 TMTC1	5.27e-05	183	98	5	dc19857b66dcadbf7c87de91f7b1f4e8ef2857ed
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ATG9B FLT1 DYSF RYR2 TMTC1	5.27e-05	183	98	5	4759560e5b4f4e5a00e5f933e3451a27c7c4aefe
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TCF21 CA10 PTPN13 ADAMTS9 RASL11B	5.27e-05	183	98	5	eb559ae3ae252d9365c24ef557dd49b78ed6d898
ToppCell	COVID-19-Heart-EC_3\|COVID-19 / Disease (COVID-19 only), tissue and cell type	ATG9B FLT1 TMTC1 PTPRG ADAMTS9	5.27e-05	183	98	5	ff95382cfed592190d0636d2b750328471f82e0d
ToppCell	LPS-IL1RA-Endothelial-Endothelial-Activated_Gen_Cap\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FLT1 DYSF TMTC1 ADAMTS9 ADGRL3	5.55e-05	185	98	5	808d5e880069aff8866cd2c733b9fe568a37701f
ToppCell	facs-Trachea-nan-3m-Endothelial\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT1 DYSF PTPRG ADAMTS9 EFR3B	6.14e-05	189	98	5	f60ac60ab9b317a0196f0cbbe520ef7dbd19ac11
ToppCell	facs-Trachea-nan-3m-Endothelial-endothelial_cell\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT1 DYSF PTPRG ADAMTS9 EFR3B	6.14e-05	189	98	5	e3d65417997bdd3f9c312c0977dceb6eca061029
ToppCell	facs-Trachea-nan-3m-Endothelial-nan\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT1 DYSF PTPRG ADAMTS9 EFR3B	6.14e-05	189	98	5	5559af03d9d612bb8dcf825e45744a9f8332bac8
ToppCell	COVID-19-Endothelial_cells-Endothelial_cells_(general)\|COVID-19 / group, cell type (main and fine annotations)	FLT1 TMTC1 PTPRG ADAMTS9 ADGRL3	6.30e-05	190	98	5	812e11314c76c0179fbe5a9bea29b41ce5cbc93d
ToppCell	facs-Limb_Muscle-ForelimbandHindlimb-3m-Endothelial-endothelial_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT1 DYSF PTPRG ADAMTS9 EFR3B	6.30e-05	190	98	5	38a815abf0ac5cac6071737cadc54a514f62d37d
ToppCell	facs-Limb_Muscle-ForelimbandHindlimb-3m-Endothelial\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT1 DYSF PTPRG ADAMTS9 EFR3B	6.30e-05	190	98	5	bb1476b44dd49e1dd52a636a91c4600b6d4fbe2e
ToppCell	facs-Limb_Muscle-ForelimbandHindlimb-3m-Endothelial-nan\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT1 DYSF PTPRG ADAMTS9 EFR3B	6.30e-05	190	98	5	d180205c70b5ca9bc5a01a2e6cb42fcebc7f630d
ToppCell	COVID-19-Endothelial_cells-Inflamed_endothelial_cells\|COVID-19 / group, cell type (main and fine annotations)	FLT1 GBE1 DYSF ADAMTS9 ADGRL3	6.78e-05	193	98	5	979ebefa527f86bebeea5d94e626ee6c1cc7d53b
ToppCell	Children_(3_yrs)-Endothelial-capillary_endothelial_cell_(Cap1)\|Children_(3_yrs) / Lineage, Cell type, age group and donor	FLT1 DYSF TMTC1 PTPRG ADGRL3	6.95e-05	194	98	5	71ac69cdf7a08ca3ddfb5b492b14ac56b6cd5e5d
ToppCell	LPS_only-Endothelial-Endothelial-Activated_Gen_Cap\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FLT1 DYSF TMTC1 ADAMTS9 ADGRL3	7.12e-05	195	98	5	56efeb58df19f357d7d5ce87348d4f196a595421
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ATG9B FLT1 TMTC1 PTPRG ADAMTS9	7.12e-05	195	98	5	818bc18c5834238e5f733cac6fe928ed0788f57d
ToppCell	10x_5'_v1-Non-neoplastic-Lymphoid-CD4/CD8-Stress_sig-F_2\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	STK17B HIP1R PTPN13 STIP1 TMEM39A	7.29e-05	196	98	5	ea8eceacc5d5e1a22b77c31e7c45985dc7bb15de
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	FLT1 DYSF TMTC1 PTPRG ADAMTS9	7.29e-05	196	98	5	7cbb19108b4553ef60ef5c230a29de1662c02efe
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Endothelial\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	FLT1 DYSF TMTC1 PTPRG ADAMTS9	7.29e-05	196	98	5	4cd1e6b7a791e11a40b19f971b7011bd11fe6273
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	FLT1 DYSF TMTC1 PTPRG ADAMTS9	7.29e-05	196	98	5	d37f714d4fb57e958f3738fdda085560813e5bb5
ToppCell	Bronchial-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_systemic_arterial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	RYR2 SMTN ADAMTS9 TBC1D1 ADGRL3	7.65e-05	198	98	5	f261a37dd07976548b897af86df1d1a0dc069889
ToppCell	metastatic_Brain-Endothelial_cells\|metastatic_Brain / Location, Cell class and cell subclass	FLT1 CUBN DYSF PTPRG ADAMTS9	7.65e-05	198	98	5	97ef7946ef11ac93318c1dd46b548dc01e5a6aba
ToppCell	3'-Pediatric_IBD-SmallIntestine-Endothelial-blood_vessel_EC-arterial_capillary\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FLT1 DYSF TMTC1 PTPRG ADAMTS9	7.65e-05	198	98	5	e9e98c20ff7b3f3851db86381550ce7085e2db9e
ToppCell	metastatic_Brain-Endothelial_cells-Tumor_ECs\|metastatic_Brain / Location, Cell class and cell subclass	FLT1 CUBN DYSF PTPRG ADAMTS9	7.65e-05	198	98	5	5e274f29cc796dae7d64d6035e904816c25f9914
ToppCell	Tracheal-10x5prime-Stromal-Myofibroblastic\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	RYR2 SMTN ADAMTS9 TBC1D1 ADGRL3	7.83e-05	199	98	5	0a145172787f40d0fdaf21188d539ffaf7ece3e4
ToppCell	Parenchymal-NucSeq-Endothelial-Endothelia_vascular-VE_systemic_venous\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ATG9B FLT1 DYSF TMTC1 ADAMTS9	7.83e-05	199	98	5	e2d5c5cab102e67b0131b02392d81adaedc15965
ToppCell	Bronchial-10x5prime-Stromal-Myofibroblastic\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	TCF21 RYR2 SMTN ADAMTS9 ADGRL3	7.83e-05	199	98	5	ad75e5e26c37a97331164d7f77235ebd9a933a44
ToppCell	Parenchymal-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_systemic_arterial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	RYR2 SMTN ADAMTS9 TBC1D1 ADGRL3	7.83e-05	199	98	5	b768496381362f9a2706e0892b5a7a0db82e09ce
ToppCell	ILEUM-inflamed-(7)_Endothelial_cell\|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	FLT1 NCKAP1 DYSF TMTC1 ADAMTS9	7.83e-05	199	98	5	97052c28e354833901f28d339b09f97f50a5b752
ToppCell	Bronchial-NucSeq-Stromal-Myofibroblastic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	RYR2 SMTN ADAMTS9 TBC1D1 ADGRL3	8.02e-05	200	98	5	a66449b22b39dd6987fc2c3ed160d24564234ced
ToppCell	COVID-19-Fibroblasts-Vascular_smooth_muscle\|COVID-19 / group, cell type (main and fine annotations)	FLT1 TCF21 RYR2 ADAMTS9 ADGRL3	8.02e-05	200	98	5	c7f82196a0768ad96b1df8b8915bc541fb118a76
ToppCell	LPS_anti-TNF-Endothelial-Endothelial-Artery\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	FLT1 TSPAN11 NCKAP1 TMTC1 PTPRG	8.02e-05	200	98	5	b1ff8d61b567f85006d6d20093f9c803b6d34674
ToppCell	saliva-Severe-critical_progression_d12-22_with-steroid-Myeloid-Monocytic-Classical_Monocyte-Mono_c2-CD14-HLA-DPB1\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	TRAPPC11 GBE1 NSMAF	1.08e-04	42	98	3	b0ebd9d2456e4bab44e91b35d728224da6a052ea
ToppCell	Control-Endothelial-Endothelial-Activated_Gen_Cap\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FLT1 HDX FGF23 ADAMTS9	1.48e-04	121	98	4	a5962d1c476e6966870832b72d511607e047248b
ToppCell	VE-CD4-CD8_1\|VE / Condition, Cell_class and T cell subcluster	DNHD1 STRIP2 AURKC UNC79	1.58e-04	123	98	4	bc0f509716bb71d6e3fa343f4920ecb80eb62794
ToppCell	facs-Brain_Non-Myeloid-Cortex_-18m-Endothelial-new-cluster\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT1 ACER1 AURKC TAS2R60	2.19e-04	134	98	4	dd0144af4f78d3483f129f908aadb1d67002aa9f
ToppCell	facs-Pancreas-Exocrine-18m-Epithelial-nan\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACVR1B STRIP2 DSTYK ADGRL3	2.38e-04	137	98	4	e9b88ad86b75454a8292a94879c5b665adc42744
ToppCell	PND07-28-samps-Endothelial-Postnatal_endothelial-endothelial_cells_D\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	ATG9B ERF NCKAP1 ACVR1B	2.59e-04	140	98	4	b9aeb7dda7f377b580dd8a44912f300721437387
ToppCell	Globus_pallidus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Slc17a6-Excitatory_Neuron.Slc17a6.Tcf7l2_(Substantia_Innominata_(SI))\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	TCF21 ITIH1 SKOR1	2.69e-04	57	98	3	eab63d89e2100bb94fb026f700c2f82d657f92c1
ToppCell	Globus_pallidus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Slc17a6-Excitatory_Neuron.Slc17a6.Tcf7l2_(Substantia_Innominata_(SI))-\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	TCF21 ITIH1 SKOR1	2.69e-04	57	98	3	2dc04513910af16d2cd84b3ae5b8d4c831124c68
ToppCell	TCGA-Breast-Metastatic-Breast_Carcinoma\|TCGA-Breast / Sample_Type by Project: Shred V9	TCF21 ITIH1 FGF23 MRO	3.28e-04	149	98	4	c7dc495141cd921b6b6f291a68851b7b807d0d0a
ToppCell	TCGA-Breast-Metastatic-Breast_Carcinoma-Infiltrating_Ductal_Carcinoma\|TCGA-Breast / Sample_Type by Project: Shred V9	TCF21 ITIH1 FGF23 MRO	3.28e-04	149	98	4	2e9b898f3df22f8e872f2c278eff454c39e55b3b
ToppCell	TCGA-Breast-Metastatic\|TCGA-Breast / Sample_Type by Project: Shred V9	TCF21 ITIH1 FGF23 MRO	3.28e-04	149	98	4	144ac2c458209ce510674bc2f83eb4c8e4d3c953
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L5_IT-L5_IT_ALM_Tnc\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	TSPAN11 GCNT2 NEB DYSF	3.71e-04	154	98	4	0066b2b8cfc74603e97f271ef5efc7ec512110dc
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-Degenerative_Endothelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FLT1 DYSF SMTN TMTC1	3.90e-04	156	98	4	ea9223bb6450b22df11efa1705ab72dab005244a
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-Degenerative_Endothelial_Cell-Degenerative_Peritubular_Capilary_Endothelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FLT1 DYSF SMTN TMTC1	3.90e-04	156	98	4	586b5509074c4cc359e9e31a968c2ded71c994ca
ToppCell	10x5'-blood-Lymphocytic_T_CD4-Trm_Th1/Th17\|blood / Manually curated celltypes from each tissue	PTPN13 BAIAP2L1 TIMELESS ARHGAP8	3.99e-04	157	98	4	c99cb26d831c25038f2aa1b1c0f7ba52facb2e7a
ToppCell	Adult-Mesenchymal-vascular_smooth_muscle_cell-D122\|Adult / Lineage, Cell type, age group and donor	RYR2 SMTN ADAMTS9 ADGRL3	4.29e-04	160	98	4	fd14dfeb7021a4b7299371854dc8fc1fd66c8dae
ToppCell	Adult-Mesenchymal-airway_smooth_muscle_cell-D122\|Adult / Lineage, Cell type, age group and donor	GCNT4 RYR2 SMTN ADGRL3	4.39e-04	161	98	4	64891f6f2ee1693c8481e951b9346e2f92d602e3
ToppCell	PND10-Immune-Immune_Myeloid-DC-cDC2-cDC2_prolif\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MCM4 TLR8 SEPTIN3 FCHSD1	4.60e-04	163	98	4	7af3d3ae7e0de733a18d0486c7ffbb5a7ef7230a
ToppCell	Children_(3_yrs)-Endothelial-endothelial_cell_of_bronchial_vessel-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	FLT1 RNF31 ADAMTS9 ADGRL3	4.60e-04	163	98	4	ba7d02db0f0e2f9916ec8db52c067c87b6917c23
ToppCell	droplet-Heart-nan-3m-Hematologic\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STK17B TLR8 BTK NCKAP1L	4.71e-04	164	98	4	df9fe446c1a43100048e11c01bf009bec3414dcf
ToppCell	severe-unassigned\|World / disease stage, cell group and cell class	DYSF ZBTB24 ZW10 ARHGAP8	4.71e-04	164	98	4	b3a45c150df6594debeeca400cc58d30ef662756
ToppCell	facs-Brain_Non-Myeloid-Cerebellum_-18m-Neuronal-SPN_Neuron_STR\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ATG9B STRIP2 FGF23 TRANK1	4.82e-04	165	98	4	1b7dfa173e83aa8c46a3153a3261866c065c3b73
ToppCell	Endothelial-endothelial_cell_of_bronchial_vessel\|World / Lineage, Cell type, age group and donor	FLT1 DYSF TMTC1 ADAMTS9	4.82e-04	165	98	4	84e553d699ac56df89a77248f7308b9133e1b683
ToppCell	facs-Brain_Non-Myeloid-Cerebellum_-18m-Neuronal-medium_spiny_neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ATG9B STRIP2 FGF23 TRANK1	4.82e-04	165	98	4	b4f7d33af7d053ec07b01bd67d861600a9c4822e
ToppCell	droplet-Limb_Muscle-nan-3m-Myeloid-unknown\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AURKC TRANK1 BTK NCKAP1L	4.93e-04	166	98	4	0a7992bc673fca546636563ec3fc17a4298ab6b1
ToppCell	NS-critical-d_0-4-Epithelial-unknown_epithelial\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	HDX CA10 SMTN PTPRG	4.93e-04	166	98	4	dd02bbe4af609c6348dc92417254f4740f2900a8
ToppCell	343B-Myeloid-Macrophage-FABP4+_Macrophage_proliferating_2\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	MCM4 CUBN ZBTB24 STRIP2	4.93e-04	166	98	4	f4698fd08965936d51695d571bd10fb77330d916
ToppCell	Globus_pallidus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Slc17a6\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	TCF21 ITIH1 SKOR1	4.93e-04	70	98	3	677deb7c7c100756a4cdc788d61feb45039a9a97
ToppCell	Endothelial-B-Donor_04\|World / lung cells shred on cell class, cell subclass, sample id	NEB RYR2 TMTC1 ADAMTS9	5.04e-04	167	98	4	6a03d16165e0b003092c39972928981abd4a75aa
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c04-COTL1\|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)	MCM4 CHRNE SMTN PIK3R2	5.04e-04	167	98	4	3b717d33aaf1ef0869cc4bca8432ba8008875cc5
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell_cycling-Cycling_Connecting_Tubule_Cell_S-high\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	MCM4 STRIP2 EFR3B TIMELESS	5.04e-04	167	98	4	108ae6221c6edc63c0ec42c42471b3a15a594043
ToppCell	Control-Lymphocytic_B-B_cells\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	STK17B HIP1R BTK NCKAP1L	5.04e-04	167	98	4	a15a70d3837b31cc83a2a9e3f1bbfd77a95f2312
ToppCell	droplet-Heart-nan-3m-Hematologic-leukocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STK17B TLR8 BTK NCKAP1L	5.04e-04	167	98	4	47447bcf184b1ad24ef17e135199fe7cd1d73c02
ToppCell	Control-Lymphocytic_B\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	STK17B HIP1R BTK NCKAP1L	5.04e-04	167	98	4	956da82394fd6a9f45fc2031796f12cc889542cd
ToppCell	Control-Lymphocytic_B-B_cells-B-cells\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	STK17B HIP1R BTK NCKAP1L	5.04e-04	167	98	4	69ed8a4a507190a1a66c4baf1f3e9be21ada39d8
ToppCell	E18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_prolif\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MCM4 GCNT4 TBC1D1 TIMELESS	5.04e-04	167	98	4	b0eb7a40491dd2432f5282f578ce569df86d21a7
ToppCell	LPS-IL1RA+antiTNF-Lymphocytic_B-B_cells-B-cells\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	STK17B HIP1R BTK NCKAP1L	5.16e-04	168	98	4	eeb381b62c7ba263af96de1194ed59e57b6ca3ae
ToppCell	LPS-IL1RA+antiTNF-Lymphocytic_B-B_cells\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	STK17B HIP1R BTK NCKAP1L	5.16e-04	168	98	4	063d0368d656962b335154c230bdcd9236e7c9ad
ToppCell	droplet-Heart-nan-3m-Hematologic-leukocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STK17B TLR8 BTK NCKAP1L	5.16e-04	168	98	4	a4eebc78babb9b5ef33065b0642793820195a613
ToppCell	LPS-IL1RA+antiTNF-Lymphocytic_B\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	STK17B HIP1R BTK NCKAP1L	5.16e-04	168	98	4	a7c4251d8a83bc30196a444028a35c17c24dc291
ToppCell	3'-Broncho-tracheal-Endothelial-Blood_vessel_EC-capillary_endothelial_cell-EC_general_capillary-EC_general_capillary_L.2.0.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FLT1 DYSF FGF23 EFR3B	5.27e-04	169	98	4	0d8b681404e18f3061d84425fb5f7d84e8e2b8d7
ToppCell	facs-Marrow-KLS-24m-Myeloid-promonocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GCNT4 STRIP2 SEPTIN3 SKOR1	5.27e-04	169	98	4	d6ad3b637de2935c656aad47ad82d6e8a8bd1227
ToppCell	facs-Pancreas-Endocrine-18m-Hematologic-nan\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STK17B TLR8 BTK NCKAP1L	5.27e-04	169	98	4	0e3d0b71fc21fd1de7034d13895608de5494fad8
ToppCell	facs-Marrow-KLS-24m-Myeloid-monocyte_+_promonocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GCNT4 STRIP2 SEPTIN3 SKOR1	5.27e-04	169	98	4	60ef186518d0dc63dbded2a77c65cfe3129df754
ToppCell	facs-Pancreas-Endocrine-18m-Hematologic\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STK17B TLR8 BTK NCKAP1L	5.27e-04	169	98	4	c68a305069a149d66dfdeef2a8010f460dc1da3b
ToppCell	droplet-Lung-nan-18m-Myeloid-Myeloid_Dendritic_Type_2\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STRIP2 SEPTIN3 TIMELESS NSMAF	5.27e-04	169	98	4	149a4f83da15bdeb170e980fb5b5b1af89ae07a6
ToppCell	facs-Pancreas-Endocrine-18m-Hematologic-leukocyte\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STK17B TLR8 BTK NCKAP1L	5.27e-04	169	98	4	80089dfb1f0f4d6bdf6ca161e902b38011992dfd
ToppCell	LPS-IL1RA-Lymphocytic_B-B_cells-B-cells\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	STK17B HIP1R BTK NCKAP1L	5.39e-04	170	98	4	92e0873f618b2fa60c4d555b10f234d5cbcf3325
ToppCell	LPS-IL1RA-Lymphocytic_B-B_cells\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	STK17B HIP1R BTK NCKAP1L	5.39e-04	170	98	4	c181991f933b779f99afc3782f292306f209e2ac
ToppCell	LPS-IL1RA-Lymphocytic_B\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	STK17B HIP1R BTK NCKAP1L	5.39e-04	170	98	4	56284fbfd1e53f67c8c0b7fba64505a4002adba2
Disease	X-linked agammaglobulinemia (implicated_via_orthology)	PIK3R1 BTK	1.07e-05	2	97	2	DOID:14179 (implicated_via_orthology)
Disease	myocardial infarction	FLT1 TCF21 WBP1L APOB REST CA10 ADGRL3	1.60e-04	350	97	7	EFO_0000612
Disease	Vasodilators used in cardiac diseases use measurement	FLT1 TCF21 APOB	1.91e-04	34	97	3	EFO_0009926
Disease	binge eating	CUBN ARHGAP8	2.96e-04	8	97	2	EFO_0005924
Disease	Agammaglobulinemia	PIK3R1 BTK	6.91e-04	12	97	2	C0001768
Disease	colorectal cancer	TFEB CUBN TMTC1 MRO ADAMTS9 PREP DSTYK SKOR1	8.62e-04	604	97	8	MONDO_0005575
Disease	Autosomal recessive limb-girdle muscular dystrophy	TRAPPC11 DYSF	9.49e-04	14	97	2	cv:C2931907
Disease	sexual dimorphism measurement	DYM WBP1L APOB REST DYSF GCNT4 AAR2 TRANK1 PTPRG PIK3R1 EFR3B	1.02e-03	1106	97	11	EFO_0021796
Disease	amenorrhea, response to antineoplastic agent	APOB TMTC1	1.09e-03	15	97	2	EFO_0010269, GO_0097327
Disease	Manic	ITIH1 TRANK1 PREP	2.19e-03	78	97	3	C0338831
Disease	lung adenocarcinoma (is_marker_for)	PTPN13 PIK3R1 BTK	2.80e-03	85	97	3	DOID:3910 (is_marker_for)
Disease	lymphocyte count	ZNF217 REST GCNT2 GTF2IRD2B SEPTIN3 BAIAP2L1 ANAPC1 PIK3R1 TBC1D1 GTF2IRD2 STIP1 NSMAF	3.07e-03	1464	97	12	EFO_0004587

Protein segments in the cluster

Peptide	Gene	Start	Entry
HKNRYINILAYDHSR	PTPRG	876	P23470
LLMYQQHTSHYDLER	CATSPERG	611	Q6ZRH7
KRYLQAHTQSVYNYH	ERF	311	P50548
AHLQHPNILRLYNYF	AURKC	96	Q9UQB9
VNAYALNSIALHILY	ACER1	141	Q8TDN7
YHQHNSAGLISRLKY	BTK	361	Q06187
FLVINYHQRVYHNRQ	ACVR1B	146	P36896
TRYIHSLQHQQLLGY	FAM216B	61	Q8N7L0
HHTLYINLISILYHQ	AAR2	291	Q9Y312
SRNHVHQLHTYYQLG	ADGRL3	1401	Q9HAR2
YEYRLQHRTVAELNH	DNHD1	2166	Q96M86
KNEELRLYHHLFNNY	CHRNE	21	Q04844
SYYRDHNVELSKLLH	NDST3	841	O95803
SYIGLSQNNLRVHYK	RANBP9	176	Q96S59
AEAHYLSYLNNLRVQ	ANAPC5	251	Q9UJX4
QKYQLLVYHADSLFH	ANAPC7	41	Q9UJX3
STDNRYHLQALRHLY	ANAPC1	1596	Q9H1A4
RLAHHLVALYYQSEE	MCM4	661	P33991
SKHLNRHLVNVYYLE	REST	1076	Q13127
YQNRNYHLTPRTSLH	HDX	366	Q7Z353
AVLALTQNHHKQYYE	ITIH1	491	P19827
YVHQELLNHKNSYVI	GCNT2	231	Q8N0V5
NILHSEITNHIYYKT	LIPJ	321	Q5W064
ASLQELYLNHNQLYR	LRRN2	141	O75325
LYTLNKHQRFGYVQH	MTG1	241	Q9BT17
HSQQLYRHIYLSCKE	EFR3B	521	Q9Y2G0
HIKVIQQYHLQYLAR	NCKAP1L	421	P55160
AVVLYLHNHSYASIQ	LNPEP	571	Q9UIQ6
DQRNTKLYQQLSHYH	MRO	221	Q9BYG7
NLYSSLKELVLHYQH	PIK3R1	686	P27986
HITSNYLKQILNAAY	DSTYK	511	Q6XUX3
LLRNAYHAVYKQSVT	NCKAP1	1111	Q9Y2A7
QYSHSIITNLLYHVV	GBA	401	P04062
NAYVTHLHAEYNRQK	SMPD2	131	O60906
HLHAEYNRQKDIYLA	SMPD2	136	O60906
ETSTNLHQKLYYHVL	PREP	201	P48147
LHQKLYYHVLGTDQS	PREP	206	P48147
LINHYRHESLAQYNA	PIK3R2	401	O00459
YLLNLVATNAHLDHY	FCHSD1	211	Q86WN1
DNALYFHLYSEHLRN	CUBN	561	O60494
TLYALSHAVNNYHKT	APOB	441	P04114
VSYHGENLQHYILTL	ADAMTS9	306	Q9P2N4
HLHDRYGQLVNVYTK	HIP1R	121	O75146
NNESYHYARRQFHLT	GBE1	556	Q04446
HIHYYHLQSAELLNS	BAIAP2L1	206	Q9UHR4
VERLIHAIYNQHNIY	GCNT4	146	Q9P109
LLYTLLHQNSNIRTY	DYM	351	Q7RTS9
TDNQYHYFLRKLRIH	EFCAB6	1106	Q5THR3
HLYTATARNSYHLQI	FGF23	41	Q9GZV9
TNRYLYFHLQQQHLI	GID8	96	Q9NWU2
DIHHRILRYTNYQVA	ATG9B	356	Q674R7
AKNVRSLLHTYHYQQ	MARF1	1491	Q9Y4F3
HDLFYHLELQVNRTY	IL22RA1	161	Q8N6P7
QRGHLSNYQYLLHLN	NSMAF	306	Q92636
DKYLLHLNQNAYTTT	SLC44A3	486	Q8N4M1
VSKEYNLRRHYQTNH	GTF2IRD2	456	Q86UP8
VSKEYNLRRHYQTNH	GTF2IRD2B	456	Q6EKJ0
VQLIHYNHELYTNVT	CA10	156	Q9NS85
LETHLDKHNIYSIYN	RYR2	3171	Q92736
LDQYLYQLRTHHLSQ	DYSF	736	O75923
RTHHVQAESYLVYNI	FAM120B	581	Q96EK7
RVSYHRNIHYNSVVN	OTUD5	326	Q96G74
QHTLTCHQYYLQLRK	PTPN13	671	Q12923
VKAHQQAYTYLHSSL	PCARE	181	A6NGG8
ALIHGLNRHYYSITI	PSMD14	191	O00487
TDYKSYELISQLHQH	RASL11B	121	Q9BPW5
IGNHRMYQNYLRNHL	TAS2R60	161	P59551
TLLKNYSYNEIHNRR	SKOR1	106	P84550
SYHLQQSQHQKVREY	TFEB	81	P19484
HNHVLYSNRSAAYAK	STIP1	36	P31948
KLNHIYQFEYVSQHL	STRIP2	586	Q9ULQ0
THHTLQQYLYKPRQE	SLC9A3	616	P48764
VYYLHQNNIVHLDLK	STK17B	146	O94768
SEKQQASHYLYVRAH	RRP7A	31	Q9Y3A4
HYKEYLVSLINAHSL	RNF31	1001	Q96EP0
FRHHFLQVLTYLQAY	TIMELESS	106	Q9UNS1
AYVLLLRSYQQNSAH	TIMELESS	706	Q9UNS1
LSHNNIYTLTDKYNL	TLR8	591	Q9NR97
NYRTAYNLVHELRAH	TRAPPC11	246	Q7Z392
YYQRALQLHPQHNRA	TMTC1	536	Q8IUR5
YHNYRQEDLLDSLIH	TMEM179	196	Q6ZVK1
ADLLQYNRAQVLYHA	TTI2	281	Q6NXR4
YNRAQVLYHAISNHL	TTI2	286	Q6NXR4
THNIHYETYRAKRLN	SEPTIN3	316	Q9UH03
SRAHLLLTDYNYVVQ	TMEM39A	206	Q9NV64
QMYQLSRLLHDYHRD	TBC1D1	936	Q86TI0
ITHNIHYENYRVIRL	SEPTIN12	301	Q8IYM1
HYENYRVIRLNESHL	SEPTIN12	306	Q8IYM1
YRYSSQLIQHQRKHN	ZNF660	311	Q6AZW8
LHLNRATLHKYEESY	TTC5	226	Q8N0Z6
SYIAHLRQILANDKY	TCF21	126	O43680
AHVYYQRLSDELKQH	TSPAN11	111	A1L157
NYLSELHEHLKYDQL	ARHGAP8	171	P85298
YFSQNRQLKSHYRVH	ZBTB24	386	O43167
RSNYYLNIHLRTHTG	ZNF217	481	O75362
QIQFPLYTAYKHNTH	USP34	166	Q70CQ2
IHQLYQNYRSHSGIL	TRANK1	1461	O15050
VNGHLYKTNYLTHRQ	FLT1	211	P17948
QHEINLIAYREAHNY	WBP1L	76	Q9NX94
TYVQSLYNHLRRHEL	SMTN	896	P53814
YLQTELHLYTEQSHK	ZW10	201	O43264
KIRYLQEYHNRVLHN	UNC79	11	Q9P2D8
VLHNSYALHGIRYKN	KIAA2013	476	Q8IYS2
DRALHAYKLQSSNLY	NEB	4936	P20929